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1

Bhat, Imtiyaz Ahmad, Moomin Hussain Bhat, Shariq Rashid Masoodi, et al. "Acute and Chronic Posterior Pituitary Insufficiency Among Traumatic Brain Injury Patients at a Tertiary Care Center." Journal of the Endocrine Society 5, Supplement_1 (2021): A623. http://dx.doi.org/10.1210/jendso/bvab048.1270.

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Abstract Background: Traumatic brain injury (TBI) is the leading cause of death and disability in young adults. Disorders of salt and water balance are the most commonly recognized medical complications in the immediate post-TBI period and contribute to early morbidity and mortality. Objective: We aimed to evaluate the prevalence of acute (during hospital stay) and chronic posterior pituitary dysfunction in patients of head injury admitted at our tertiary care hospital. Study Design: Prospective, Observational study. Participants: 136 patients, attending tertiary care in North India with TBI w
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ZAHRA, M., A. MUNIR, S. CHOUDHRY, et al. "CLINICAL SPECTRUM OF DISEASE IN NEONATES BORN TO MOTHERS WITH COVID-19 IN A TERTIARY CARE HOSPITAL." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 1117. http://dx.doi.org/10.54112/bcsrj.v2024i1.1117.

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COVID-19 infection during pregnancy presents potential risks to neonates, yet the full clinical spectrum in newborns born to COVID-19-positive mothers remains under investigation. Understanding the clinical outcomes in these neonates is essential for guiding management and care. Objective: To study the spectrum of clinical presentations in neonates born to mothers who tested positive for COVID-19. Methods: This prospective cross-sectional study was conducted at the Department of Pediatrics, Shifa International Hospital, from April 1, 2020, to April 30, 2021. All neonates born to COVID-19-posit
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AFTAB, RUSHDA. "NEONATAL SEIZURES." Professional Medical Journal 14, no. 02 (2007): 199–203. http://dx.doi.org/10.29309/tpmj/2007.14.02.4868.

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Introduction: Seizures in the neonates are quite different from those in older children and adults,whereas seizures in preterm differ from those of term infant. Neonatal seizures are poorly organized and at timesinconspicuous, they also differ in origin from those of older children as they frequently arise in subcortical areas whilein older children they arise from cortex. Objective: To find out the frequency of seizures and determine the frequencyof various types of neonatal seizures among newborns admitted to Nishtar Hospital, Multan. Material and Methods:Setting: Pediatric Unit-I, Nishtar H
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Ali, Shabahat, Rana Muhammad Umar, Furqan Yaqub Pannu, Faryad Ali, Qazi Abdul Saboor, and Bilal Ahmed. "Frequency of Acute Kidney Injury in Patients Presenting with Acute ST-Elevation Myocardial Infarction and Its Relationship with In-Hospital Mortality." Pakistan Journal of Medical and Health Sciences 16, no. 11 (2022): 224–27. http://dx.doi.org/10.53350/pjmhs20221611224.

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Objective: To determine the frequency of acute kidney injury in patients presenting with acute ST elevation myocardial infarction and to compare the frequency of in-hospital mortality between patients presenting with acute ST elevation myocardial infarction with versus without acute kidney injury at a tertiary care hospital. Design: It was a descriptive case series. Study Settings: Department of Cardiology, Shaikh Zayed Hospital Lahore-Pakistan over a period of 6 months from January 2021 to June 2021. Material and Methods: A total of 128 patients of both genders aged between 18-70 years presen
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Holstein, Rachel, Fatima S. Dawood, Pam Daily Kirley, et al. "128. Characteristics and Outcomes of Pregnant Women Hospitalized with Influenza in the United States, Flusurv-net, 2010–2019." Open Forum Infectious Diseases 7, Supplement_1 (2020): S193—S194. http://dx.doi.org/10.1093/ofid/ofaa439.438.

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Abstract Background Pregnant women are at high-risk for influenza-associated hospitalization. We used data from the U.S. Influenza Hospitalization Surveillance Network (FluSurv-NET) to characterize pregnant women hospitalized with influenza. Methods We included pregnant women (15–44 years) residing within a FluSurv-NET catchment area and hospitalized with laboratory-confirmed influenza between October 1 and April 30, during the 2010–19 influenza seasons. Clinical data were obtained on cases through medical chart abstraction. We examined trends in vaccination coverage and antiviral treatment us
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Dr., Shazad Najeeb Dr. Arshad Sohail DR. Muhammad Ali Raza Dr. Chetan Das Priya Hotwani Dr. Suresh Kumar Rathi*. "FREQUENCY OF NECROTIZING ENTEROCOLITIS IN PRETERM NEONATES AND THEIR OUTCOME DURING HOSPITAL STAY." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2087–94. https://doi.org/10.5281/zenodo.835557.

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Background: Neonatal necrotizing enterocolitis [NEC], characterized by intestinal necrosis and pneumatosis intestinal, is the most common gastrointestinal emergency in the premature newborns[1] . The disease has an incidence rate of 2 to 5% in premature infants. The incidence rate increases to 13% in those weighing 1,500 gram at birth. NEC has a mortality rate of 10 to 55%. Objective: To determine the frequency of necrotizing enterocolitis in preterm neonates along with their outcome during stay in hospital. Methods: All premature newborn with morbidity admitted at Neonatal Intensive Care Unit
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Le, Jennifer, Tu T. Tran, Ivilynn Bui, Mike K. Wang, Andrew Vo, and Felice C. Adler-Shohet. "Time to Initiation of Antifungal Therapy for Neonatal Candidiasis." Antimicrobial Agents and Chemotherapy 57, no. 6 (2013): 2550–55. http://dx.doi.org/10.1128/aac.02088-12.

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ABSTRACTThe effect of delayed antifungal therapy in critically ill infants with invasive candidiasis has not been studied. Our objective was to evaluate the effect of time to initiation of antifungal therapy (TIA) on mortality, disseminated disease, and postinfection hospital stay. We conducted a cohort study of critically ill infants with cultures positive forCandidafrom 1990 to 2008. TIA was defined as the number of hours from the collection of the first positive culture until the start of antifungal therapy. Of 96 infants, 57% were male, the median gestational age was 27 weeks (range, 23 to
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Gee, Siobhan, Vasco Almeida, Adam Hughes, Isabel McMullen, and David Taylor. "Reasons for admission to a general medical hospital for patients taking clozapine." Therapeutic Advances in Psychopharmacology 12 (January 2022): 204512532211367. http://dx.doi.org/10.1177/20451253221136753.

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Background: Clozapine is associated with a diverse range of side effects. In addition, patients prescribed clozapine commonly suffer with medical comorbidities. Objectives: This study aimed to characterise patients prescribed clozapine who required medical admission, understand reasons for admission, identify areas for interventions to prevent future admission and describe clozapine management during the inpatient stay. Design: We conducted a retrospective analysis of patients prescribed clozapine who were admitted to a general medical hospital in a 12-month period. Method: Data were collected
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Lukyanov, M. M., N. P. Kutishenko, S. Yu Martsevich, et al. "Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registry." Russian Journal of Cardiology 27, no. 3 (2022): 4912. http://dx.doi.org/10.15829/1560-4071-2022-4912.

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Aim. To assess long-term outcomes within 12 months after hospital treatment of patients with coronavirus disease 2019 (COVID-19) as part of a prospective registry.Material and methods. Outcomes in the posthospital period were assessed in 827 patients diagnosed with COVID-19 (age, 58,0±14,8 years; men, 51,3%). For periods of 30-60 days, 6 and 12 months after discharge from the hospital, cases of death, nonfatal myocardial infarction (MI) and stroke, hospitalization, acute respiratory viral infections/influenza were assessed. The follow-up period was 13,0±1,5 months.Results. During the follow-up
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Akpanudo EI, Ituen AM, Eyo AE, and Emmanuel EM. "Ileostomies for severely ill children with ileo-colic intussusception: our experience at the University of Uyo Teaching Hospital." Ibom Medical Journal 17, no. 2 (2024): 251–59. http://dx.doi.org/10.61386/imj.v7i2.432.

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Context: Complicated intussusception is associated with life-threatening intestinal gangrene and peritonitis. In critically ill children, a primary ileocolic anastomosis may increase their morbidity and mortality and, thus, a temporary ileostomy may be a safer option. Objective: The purpose of this study is to report the indications, outcomes, and complications after temporary ileostomies for infants with ileocolic intussusception in our institution. Materials and methods: This was a retrospective study of infants who had ileostomies created in our institution following complicated ileocolic i
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Vachon, Eric, and Victoria Champion. "Mortality results from an oral oncolytic symptom management trial." Journal of Clinical Oncology 37, no. 15_suppl (2019): e23139-e23139. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e23139.

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e23139 Background: Although mortality rates have declined, cancer remains the second leading cause of death in the United States. There has been an increase in prescriptions of oral oncolytic agents (OOA), which are typically prescribed to late stage patients as third or fourth line therapy. Because of this, death rates are higher among these patients and may impact attrition rates in OOA intervention trials. For researchers working with late stage patients, attrition by mortality should be considered when determining sample size. The purpose of this report is to identify the mortality inciden
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Medam, Rajesh Babu, Venugopal Reddy Iragamreddy, Akhila H. B., and Murali Mohan Voona. "Effect of inhaled budesonide therapy in term newborns with meconium aspiration syndrome." International Journal of Contemporary Pediatrics 10, no. 7 (2023): 1033–39. http://dx.doi.org/10.18203/2349-3291.ijcp20231838.

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Background: Meconium aspiration syndrome is a common cause of respiratory distress in neonates. This study explores the possibility of altering the course of the disease by using anti-inflammatory agents to counter the chemical and inflammatory pneumonitis caused by meconium. The objective is to determine if inhaled budesonide therapy can alter the clinical course of the disease and improve outcome without causing any serious adverse effects. Methods: A comparative study was conducted in NICU of Cheluvamba hospital, Mysore over 12 months. Neonates with MAS were divided into interventional and
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Castellucci, Lana A., and Philip Chiang. "Management of Cerebral Vein Thrombosis in a Canadian Tertiary Hospital." Blood 132, Supplement 1 (2018): 2532. http://dx.doi.org/10.1182/blood-2018-99-118369.

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Abstract Introduction: Cerebral vein thrombosis (CVT) is an uncommon cause of stroke and is more likely to affect young adults and children. Women have a three-fold increased risk compared to men, owing to gender specific factors such as oral contraceptive use (OCP), pregnancy, and hormone replacement therapies. The presenting symptoms of CVT are non-specific and include headache, seizure, focal neurological deficits, or coma as the most severe presentation. The rarity and variable symptoms of the disease leads to delayed diagnosis and implementation of treatment. With improved imaging techniq
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Sarfaraz, Samreen, Quratulain Shaikh, Syed Ghazanfar Saleem, et al. "Determinants of in-hospital mortality in COVID-19; a prospective cohort study from Pakistan." PLOS ONE 16, no. 5 (2021): e0251754. http://dx.doi.org/10.1371/journal.pone.0251754.

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A prospective cohort study was conducted at the Indus Hospital Karachi, Pakistan between March and June 2020 to estimate the in-hospital mortality among hospitalized COVID-19 patients and its determinants. A total of 170 adult patients were enrolled and all-cause mortality was found to be 39% (67/170). Most non-survivors were above 60 years of age (64%) while gender distribution was quite similar in both groups (males: 77% vs 78%). Most (80.6%) non-survivors came with peripheral oxygen saturation less than 93% while 95% of them had critical disease on arrival. Use of non-invasive ventilation i
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Shah, Sunish, Dayna McManus, Nika Bejou, et al. "2645. Clinical Outcomes of Oseltamivir vs. Baloxavir in Patients Hospitalized with Influenza A." Open Forum Infectious Diseases 6, Supplement_2 (2019): S925. http://dx.doi.org/10.1093/ofid/ofz360.2323.

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Abstract Background Baloxavir marboxil is a new antiviral agent for the treatment of acute uncomplicated influenza in patients > 12 years of age who have been symptomatic for no more than 48 hours. However, clinical trials to date have excluded patients hospitalized with influenza infection. Methods This study was a multi-center, retrospective chart review of adult patients admitted to the hospital who received oseltamivir or baloxavir for the treatment of influenza A. Patients were screened for inclusion between January 2018 and February 2018 in the oseltamivir group while patients in the
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Gupta, Bal Kishan, Kashish Narula, Makhan Lal Saini, Rakesh Kumar Baberwal, and Jigyasa Gupta. "Clinical Evaluation of Significance of 25(Oh)D (Vitamin D) Status in Swine Flu (H1N1)." International Journal of Nutrition 6, no. 2 (2020): 1–17. http://dx.doi.org/10.14302/issn.2379-7835.ijn-20-3369.

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Background Since swine flu has been declared pandemic in 2009 it has become a major challenging public-health problem associated with high morbidity and mortality. 25(OH)D deficiency is also pandemic and has been reported to be clinically correlated with decreased immunity and respiratory infections. The possible role of vitamin D in infections is implied from its impact on the innate and adaptive immune responses. This study is planned to evaluate clinical significance of 25(OH)D status on course and outcome in hospitalized cases of swine flu and to compare it with normal healthy subjects liv
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Rahman, A. K. M. Ferdous, Saifullah Al Kafi, and Zannatul Naiem. "Study on Clinical Profile and Treatment Outcome of Acute Paraquat Poisoning in an Intensive Care Unit in Bangladesh." Journal of Medicine 25, no. 2 (2024): 129–35. http://dx.doi.org/10.3329/jom.v25i2.74666.

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Background: Paraquat, one of the most widely used herbicides, is a major cause of self-harm related death in Bangladesh resulting from multiple organ failure. The primary objective aimed to identify the demographic & clinical characteristics of paraquat poisoning and the outcome of different treatment modalities. Materials and Methods: A prospective observational study was conducted over twenty-four months at the Intensive Care Unit of Dhaka Medical College Hospital, a tertiary care referral hospital.Between March 2022 and March 2024, patients presenting with acute paraquat toxicity who fu
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Mushtaq, Asma, Aysha Mansoor Lodhi, Wajiha Rizwan, Carol Ruth, Meher Muzaffar, and Arooj Mir. "Clinical spectrum and outcome of extra-pulmonary tuberculosis in children." Professional Medical Journal 28, no. 09 (2021): 1336–40. http://dx.doi.org/10.29309/tpmj/2021.28.09.6361.

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Objective: To determine the types, clinical spectrum and outcome of Extra-Pulmonary Tuberculosis (EPTB) in children admitted at a tertiary care hospital. Study Design: Cross Sectional study. Setting: The Children's Hospital and The Institute of Child Health, Lahore. Period: May to December 2019. Material & Methods: A total of 63 patients diagnosed with EPTB aged 1 month to 16 years were included. All patients with lung involvement were excluded from the study. Anti-tuberculous therapy (ATT) was started in all patients and outcome was monitored during the hospital stay. Results: In a total
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Lazar Neto, Felippe, Cassio Murilo Trovo Hidalgo Filho, Joao Wilson Da Rocha, Renata Colombo Bonadio, and Paulo Marcelo Hoff. "Hospitalization and post-discharge survival outcomes of adolescents and young adults with cancer." Journal of Clinical Oncology 40, no. 16_suppl (2022): e18687-e18687. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e18687.

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e18687 Background: Cancer incidence has increased among adolescents and young adults (AYA) over the last two decades. Younger patients often present with late diagnosis, aggressive disease, and are more likely to receive chemotherapy during cancer treatment. We investigated admission outcomes and post-discharge survival of AYA who were hospitalized after urgent admission. Methods: Retrospective cohort of patients with solid tumor diagnosis and age between 18 and 39 years, hospitalized after urgent admission to a tertiary, publicly-funded, cancer hospital in São Paulo, Brazil, from February 1st
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Neuzillet, Cindy, Corinne Emery, Clément Teissier, Stéphane Bouée, and Astrid Lièvre. "Epidemiology and patterns of care of intrahepatic cholangiocarcinoma (iCCA) in France: Real-life data from the French National Hospital‐Discharge Summaries Database System (PMSI)." Journal of Clinical Oncology 38, no. 15_suppl (2020): e16624-e16624. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16624.

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e16624 Background: Little is known about epidemiology and patterns of care of iCCA in daily clinical practice. The aims of this study were to estimate from real-life data the incidence of iCCA in France and to describe the healthcare pathways of these patients (pts). Methods: A retrospective analysis was carried out using the nationwide prospective French PMSI database. All pts with a new diagnosis of "carcinoma of the intrahepatic bile duct" who had a 1st hospital stay in Medicine, Surgery and Obstetrics departments (MSO) between 2014 and 2015 with a 2-year follow-up were included. Data relat
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Patel, Ajay P., Eugene M. Langan, Spence M. Taylor, et al. "An Analysis of Standard Open and Endovascular Surgical Repair of Abdominal Aortic Aneurysms in Octogenarians." American Surgeon 69, no. 9 (2003): 744–48. http://dx.doi.org/10.1177/000313480306900903.

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While elective open abdominal aortic aneurysm (AAA) repair has been shown to be safe in selected octogenarians, very little is known about the role of endovascular AAA exclusion in this high-risk cohort. A retrospective review of our vascular surgical registry from January 1996 to December 2001 revealed 51 octogenarians that underwent infrarenal AAA repair. Since 1999 all octogenarians who presented for AAA repair were evaluated for preferential endovascular stent graft placement. Over the 6-year period, 35 patients underwent standard open repair while 16 patients were found to be anatomic can
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Zaidi, Syed Shahid Nafees, Inamullah Khan, Nausheen Bakht, et al. "SURGERY OF TETRALOGY OF FALLOT-15 YEAR EXPERIENCE AT AFIC-NIHD RAWALPINDI." Pakistan Armed Forces Medical Journal 70, Suppl-4 (2021): S881–86. http://dx.doi.org/10.51253/pafmj.v70isuppl-4.6048.

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Objective: To compare trans-atrial/Trans-pulmonary and trans-annular/trans-ventricular techniques of surgical correction of tetralogy of fallot.
 Study Design: Descriptive cross sectional study.
 Place and Duration of Study: AFIC-NIHD Rawalpindi, from Jan 2005 to Jan 2020.
 Methodology: Pre-op variables included age, gender, weight, SaO2 and any previous operation (like Modified Blalock Taussig Shunt.) Operative variables were any previous Blalock Taussig Shunts and if present, then their takedown, Cardiopulmonary Bypass Time, Aortic Clamp Time, any Right Ventricle - Pulmonary A
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Uddin, KMF, N. Jahan, MA Manan, et al. "Risk Factors Determining the Outcome of 2-12 Months Age Group Infants Hospitalized With Severe Pneumonia." Medicine Today 25, no. 1 (2013): 9–13. http://dx.doi.org/10.3329/medtoday.v25i1.15901.

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Pneumonia is one of the leading causes of morbidity and mortality in under fives throughout the world, particularly in developing countries. A case control study was carried out in Bangabandhu Memorial Hospital, University of Science and Technology during the period of January to July 2006. 192 hospitalized infants of 2–12 months age group with World Health Organization(WHO) defined severe pneumonia with radiological confirmation were enrolled in the study, while controls were normal infant of same age group attending EPI center for vaccination. The children were managed using a standard proto
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Branche, Angela, Lisa Saiman, Edward E. Walsh, et al. "2315. The Relationship of Pre-Hospital Functional Status and Clinical Outcomes in Patients with Laboratory-Confirmed RSV Infection: Active Population-Based Surveillance, 2017–2019." Open Forum Infectious Diseases 6, Supplement_2 (2019): S794. http://dx.doi.org/10.1093/ofid/ofz360.1993.

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Abstract Background Respiratory syncytial virus (RSV) infection is a common cause of acute respiratory infection (ARI) in adults. Prospective surveillance enables collection of representative data on demographic and clinical characteristics. Few data of this kind are available for adults hospitalized with RSV infection. We used active population-based surveillance to identify patients with laboratory-confirmed RSV infection and evaluated demographic characteristics and clinical outcomes. Methods Hospitalized adults ≥ 18 years old residing in a predefined catchment area with ≥ 2 ARI symptoms or
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COŞKUN, AYŞENUR SÜMER, and ŞENAY ÖZTÜRK DURMAZ. "Fungal Infections in COVID-19 Intensive Care Patients." Polish Journal of Microbiology 70, no. 3 (2021): 395–400. http://dx.doi.org/10.33073/pjm-2021-039.

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Opportunistic fungal infections increase morbidity and mortality in COVID-19 patients monitored in intensive care units (ICU). As patients’ hospitalization days in the ICU and intubation period increase, opportunistic infections also increase, which prolongs hospital stay days and elevates costs. The study aimed to describe the profile of fungal infections and identify the risk factors associated with mortality in COVID-19 intensive care patients. The records of 627 patients hospitalized in ICU with the diagnosis of COVID-19 were investigated from electronic health records and hospitalization
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Hedaoo, Ketan, Vikas Rajpurohit, Sunil Garg, Sharad Thanvi, and Vallabh B. Nagocha. "GCS score and MRI grading does not predicts the outcome in dai patients - a prospective study." Romanian Neurosurgery 32, no. 2 (2018): 314–21. http://dx.doi.org/10.2478/romneu-2018-0039.

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Abstract Diffuse axonal injury (DAI) is a type of brain injury due to extensive lesions in white matter tract occurring over a wide area. It is one of the most common and devastating types of traumatic brain injury and major cause of unconsciousness and persistent vegetative state after head trauma. DAI occurs in about half of all cases of severe head trauma. The study was undertaken to correlate the GCS at time of admission and Grade of DAI with the outcome. Aim: - To correlate GCS Score and MRI grading with the outcome in DAI patients. Setting and Design: - A 3 months prospective study was c
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Ahmad, Mir Mujtaba, Raja Nadeem, Musharraf Husain, Irfan Nazir, and Manzoor Ahmad. "Stapled haemmorhoidopexy versus open haemorrhoidectomy: our initial experience." International Surgery Journal 4, no. 5 (2017): 1672. http://dx.doi.org/10.18203/2349-2902.isj20171619.

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Background: Haemorrhoids or ‘Piles’ is a frequently observed disease in surgical practice. Various non-surgical and surgical treatments are available. Open haemorrhoidectomy (Milligan-Morgan) is a widely-used procedure. A recent novel technique called ‘Stapled haemorrhoidopexy’, first described and performed by Italian surgeon Antonio Longo is gaining worldwide recognition for its benefits.Methods: A total of 155 patients between the age group of 20 and 65 years, diagnosed to have grade III or IV haemorrhoids were included in the study, divided into 2 groups, Group 1 undergoing Open haemorrhoi
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Perri, G., G. Brancaccio, S. Filippelli, et al. "LONG TERM OUTCOME OF TETRALOGY OF FALLOT AND COMPLETE ATRIOVENTRICULAR SEPTAL DEFECT REPAIR: SINGLE CENTRE EXPERIENCE." Journal of Cardiovascular Medicine 25, Supplement 1 (2024): e37. https://doi.org/10.2459/01.jcm.0001096572.82444.e3.

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Background: We report our experience following surgical repair of Complete Atrioventricular Septal Defect (cAVSD) with Tetralogy of Fallot (TOF) over a 30 years period, focusing particularly in approach used for right ventricular outflow tract reconstruction (RVOTR). Methods: Between 1992 and 2023, 47 children with primary diagnosis of cAVSD/TOF were treated in our Institution; 39 had Down’s syndrome (81%). All except 6 had diagnosis of Rastelli’s type C. Median age and weight at surgery were 25 mos (range 4 – 224) and 12.5 Kg (range 3.5 – 83). 22 patients received initial palliation while 25
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Abu Freha, Naim, Muhammad Abu Tailakh, Doron Schwartz, et al. "Accidental Hijab Pin Ingestion: 10 Years Experience from a Tertiary Care Centre." Integrative Gastroenterology and Hepatology 1, no. 1 (2018): 54–59. http://dx.doi.org/10.18314/igh.v1i1.1178.

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Background and Aim: Hijab pins ingestion is increasing. Some women hold the pin between their teeth while arranging the Hijab and the inadvertent ingestion of the pin can be the result of any careless movements. The aims of our study were to investigate the clinical outcomes of patients who underwent endoscopic pin removal via gastroscopy as opposed to patients who were treated conservatively with clinical observation, and to compare clinical and endoscopic data pertaining to patients who underwent early versus late gastroscopy.Methods: Muslim women hospitalized in a tertiary hospital from 200
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Alessandrini, Letizia, and Budi Wicaksono. "Characteristics of PPROM in General Hospital Dr. Soetomo Surabaya Period September 2017 to September 2019." International Islamic Medical Journal 2, no. 2 (2021): 81–87. http://dx.doi.org/10.33086/iimj.v2i2.1838.

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Background: Preterm Prelabour Rupture of Membranes (PPROM) is one of the causes of perinatal morbidity and mortality. Objective: To find out the characteristic of PPROM in Dr. Soetomo Hospital in September 2018 to September 2019. Method: A Retrospective Descriptive Study. The data came from the medical records of patients with PPROM who were included in the inclusion criteria. The exclusion criteria is all PPROM cases at Gestational age > 34 weeks. Result: The incidence of PPROM during September 2017 to September 2019 was 6.8% (175 patients), of which 152 patients included NBC cases and 23
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Atak, Ibrahim. "Anorectal Malignant Melanoma: Retrospective Analysis of Six Patients and Review of the Literature." Prague Medical Report 119, no. 2-3 (2018): 97–106. http://dx.doi.org/10.14712/23362936.2018.9.

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Malignant melanomas are rare aggressive tumours originating from the pigment-producing melanocytes. In our study, a review of the literature and a retrospective analysis of patients undergoing surgery at our clinic due to anorectal malignant melanoma were performed. The information of 6 patients undergoing surgery in our clinic due to anorectal malignant melanoma between January 2010 and January 2018 was retrieved retrospectively. The patients were assessed regarding demographic data, physical examination and imaging findings, the surgical method performed, postoperative complication, histopat
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Castillo, Rafael Ricafranca, Gino Rei A. Quizon, Mario Joselito M. Juco, et al. "Melatonin as adjuvant treatment for coronavirus disease 2019 pneumonia patients requiring hospitalization (MAC-19 PRO): a case series." Melatonin Research 3, no. 3 (2020): 297–310. http://dx.doi.org/10.32794/mr11250063.

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Treatment for coronavirus disease 2019 (COVID19) pneumonia remains empirical and the search for therapies that can improve outcomes continues. Melatonin has been shown to have anti-inflammatory, antioxidant, and immune-modulating effects that may address key pathophysiologic mechanisms in the development and progression of acute respiratory distress syndrome (ARDS), which has been implicated as the likely cause of death in COVID19. We aimed to describe the observable clinical outcomes and tolerability of high-dose melatonin (hdM) given as adjuvant therapy in patients admitted with COVID19 pneu
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Dakwar, Elias, Stephen I. Rifkin, Ildemaro J. Volcan, J. Allan Goodrich, and Juan S. Uribe. "Rhabdomyolysis and acute renal failure following minimally invasive spine surgery." Journal of Neurosurgery: Spine 14, no. 6 (2011): 785–88. http://dx.doi.org/10.3171/2011.2.spine10369.

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Minimally invasive spine surgery is increasingly used to treat various spinal pathologies with the goal of minimizing destruction of the surrounding tissues. Rhabdomyolysis (RM) is a rare but known complication of spine surgery, and acute renal failure (ARF) is in turn a potential complication of severe RM. The authors report the first known case series of RM and ARF following minimally invasive lateral spine surgery. The authors retrospectively reviewed data in all consecutive patients who underwent a minimally invasive lateral transpsoas approach for interbody fusion with the subsequent deve
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Stabile, Eugenio, Donato Gerardi, Fabio Magliulo, et al. "One-Year Clinical Outcomes of the Legflow Drug-Coated Balloon for the Treatment of Femoropopliteal Occlusions Registry." Journal of Endovascular Therapy 26, no. 1 (2019): 26–30. http://dx.doi.org/10.1177/1526602818823557.

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Purpose: To report the 1-year outcomes of the prospective Legflow drug-coated balloon (DCB) registry, which evaluated the safety and 12-month efficacy of the Legflow balloon in the treatment of femoropopliteal disease. Methods: The Legflow is a new generation of DCB that has a homogenous, stable surface coating incorporating 0.1-µm paclitaxel particles. From January 2014 to June 2016, 139 patients (mean age 67.1±10.8 years; 109 men) were enrolled at 4 European institutions. Seventy-nine (56.8%) patients had claudication, while 60 (43.2%) had critical limb ischemia (CLI). Mean lesion length (ML
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Papadopoulos, N. E., O. Eton, K. B. Kim, L. H. Camacho, P. Hwu, and A. Y. Bedikian. "Phase II study of ‘hybrid‘ biochemotherapy for advanced melanoma." Journal of Clinical Oncology 24, no. 18_suppl (2006): 18007. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.18007.

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18007 Background: The clinical activity of a hybrid biochemotherapy regimen was determined. This regimen incorporated important elements of previously studied sequential and concurrent biochemotherapy regimens in order to potentially increase dose intensity of the antitumor agents while decreasing morbidity, complexity of in-patient management, and length of hospital days. Methods: The antitumor agents and starting doses in the hybrid regimen were: cisplatin (25 mg/m2) IV on days 2–5, vinblastine (1.4–1.6 mg/m2) IV on days 1–5, dacarbazine (800 mg/m2) IV day 1 only, rIL-2 (12 MIU/m2) SC on day
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Tsuda, Etsuko, Yoshio Arakaki, Toshio Shimizu, et al. "Changes in causes of sudden deaths by decade in patients with coronary arterial lesions due to Kawasaki disease." Cardiology in the Young 15, no. 5 (2005): 481–88. http://dx.doi.org/10.1017/s1047951105001344.

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Over a 25-year period, we encountered 12 patients who died suddenly with coronary arterial lesions due to Kawasaki disease. We report their clinical course, and analyze the happenings of their deaths. Of the 12 patients, 10 were dead on arrival at hospital. Their age at death ranged from 13 months to 27 years, with a median of 16 years, and the interval from the onset of Kawasaki disease to death ranged from 2 months to 24 years. In 4 patients, death was found to be due to myocardial infarction, while in the remaining 8, it could not be determined. In 7 patients, coronary angiograms obtained l
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Serota, David P., Colleen Kelley, Jesse T. Jacob, Susan M. Ray, Marcos C. Schechter, and Russell Kempker. "1020. Injection Drug Use-Associated Staphylococcus aureus Bacteremia in a Large Urban Hospital in Atlanta, Georgia." Open Forum Infectious Diseases 5, suppl_1 (2018): S304. http://dx.doi.org/10.1093/ofid/ofy210.857.

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Abstract Background Infectious complications of injection drug use (IDU) have increased with the expanding opioid epidemic in the southeast. We assessed the incidence, clinical presentation, and treatment outcomes of IDU-associated Staphylococcus aureus (SA) bacteremia (SAB). Methods We created a retrospective cohort of all adults with community acquired (CA) SAB over 5 years presenting to Grady Memorial Hospital, a 1,000-bed urban county hospital in Atlanta, GA. Charts were reviewed by infectious diseases physicians to obtain clinical and laboratory characteristics, including substance use di
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38

Gohil, Vikram B., Swarnim U. Thakur, Smit M. Mehta, and Firdaus A. Dekhaiya. "Comparative study of laparoscopic and open surgery in management of 50 cases of liver hydatid cyst." International Surgery Journal 7, no. 4 (2020): 1099. http://dx.doi.org/10.18203/2349-2902.isj20201170.

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Background: Echinococcosis is caused by parasite called Echinococcus granulosus and Echinococcus multilocularis. The modern treatment of hydatid cyst of the liver varies from surgical intervention to percutaneous drainage or medical therapy.Methods: This clinical study was done on 50 patients who had liver hydatid disease admitted in Sir T Hospital, Bhavnagar from August 2013 to February 2016. Patients were divided into two groups consisting of 25 cases in each. Group A: managed by open surgery. Group B: managed by laparoscopic surgery. All patients followed up for 6 months after surgery.Resul
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Schad, Friedemann, Anja Thronicke, Phillipp von Trott, and Shiao Li Oei. "Analysis of Changes in Cancer-Related Fatigue of Breast Cancer Patients Receiving an Integrative Medicine Program." Integrative Cancer Therapies 19 (January 2020): 153473542096378. http://dx.doi.org/10.1177/1534735420963780.

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Introduction: Cancer-related fatigue (CRF) occurs frequently in breast cancer patients. The aim of this real-world study was to analyze the longitudinal changes of CRF in breast cancer patients receiving an integrative medicine program, which includes the application of non-pharmacological interventions (NPIs) and Viscum album L. (VA) extracts. Methods: All data were collected from the clinical register of the Network Oncology of a German certified breast cancer center of the Gemeinschaftskrankenhaus Havelhöhe (GKH). Primary breast cancer patients, treated upon initial diagnosis with integrate
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Rajkumar Verma, Pooja Prajapati, and Prashant Kumar. "Comparative study of laser versus open lateral internal sphincterotomy in the treatment of anal fissure." Asian Journal of Medical Sciences 14, no. 11 (2023): 287–92. http://dx.doi.org/10.3126/ajms.v14i11.53982.

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Background: Anal fissure is a common proctological problem that causes anal pain during and after defecation. An anal fissure is a linear ulcer that presents at the anal verge. It is more common in females than males and can be seen either in the anterior or posterior midline, just distal to the dentate line. Aims and Objectives: Comparison of Laser versus Open lateral internal sphincterotomy (LIS) in the treatment of anal fissures. Materials and Methods: The study was conducted in 50 cases of Open LIS compared with 50 cases of laser LIS (LLIS) in patients admitted to the Department of Surgery
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Rahman, Shamimur, Ratan Das Gupta, Nazrul Islam, et al. "Pregnancy Related Acute Renal Failure in a Tertiary Care Hospital in Bangladesh." Journal of Medicine 13, no. 2 (2012): 129–32. http://dx.doi.org/10.3329/jom.v13i2.12739.

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Background: Pregnancy related acute renal (PRARF) failure is more common in developing countries than developed country. Improved antenatal care and obstetric care reduce PRARF in developed country. In Bangladesh maternal mortality rate is 3.8/1000 population of which 25% account for acute renal failure. We try to find out cause, risk factor and out come of pregnancy related acute renal failure. Materials and Methods: A prospective observational study was done to observe the status of ARF in pregnancy in Nephrology Department of Dhaka Medical College during 2007-2008. All patients were undergo
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Tapson, Victor F., Herve Decousus, Jean-Fran[ccedi]ois Bergmann, et al. "The International Medical Prevention Registry on Venous Thromboembolism (IMPROVE): Venous Thromboembolism Prophylaxis Practices in Acutely Ill Medical Patients." Blood 104, no. 11 (2004): 1762. http://dx.doi.org/10.1182/blood.v104.11.1762.1762.

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Abstract Background Despite consensus group recommendations indicating that medical patients should receive appropriate venous thromboembolism (VTE) prophylaxis, prophylaxis practices remain poorly characterized. This analysis of IMPROVE, a prospective study of acutely ill medical patients, describes in-hospital prophylaxis practices prior to the publication of updated VTE prevention guidelines by the American College of Chest Physicians. Methods Patient recruitment began in July 2002. Patients ≥18 years old, and hospitalized for ≥3 days with an acute medical illness are enrolled consecutively
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Gaddh, Manila, Bernice Fokum, Hamid Bouiri, Augustin Haidau, and Margaret Telfer. "Prologed Use of Pegylated Liposomal Doxorubicin In An HIV-Infected Population with Kaposi's Sarcoma at An Inner-City Safety Net Hospital." Blood 116, no. 21 (2010): 4873. http://dx.doi.org/10.1182/blood.v116.21.4873.4873.

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Abstract Abstract 4873 Introduction: Kaposi's sarcoma (KS) is a low-grade HHV-8 associated vascular tumor that is particularly prevalent in patients infected with HIV. The mainstay of treatment is HAART, which has decreased the aggressiveness, and possibly the prevalence of this disease. Cytotoxic chemotherapy is generally added for moderate to severe symptomatic disease, with Pegylated Liposomal Doxorubicin (Doxil) being the treatment of choice. Studies have shown that unlike regular anthracyclines, Doxil can be safely administered over long periods at low doses without inducing cardio toxici
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Ku, Geoffrey Yuyat, Abraham Jing-Ching Wu, Smita Sihag, et al. "Durvalumab (D) and PET-directed chemoradiation (CRT) after induction FOLFOX for esophageal adenocarcinoma." Journal of Clinical Oncology 39, no. 3_suppl (2021): 226. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.226.

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226 Background: Based on the positive results of the CALGB 80803 study (J Clin Oncol 2017;35:1 [abstr]), we have added D to induction FOLFOX and pre-op CRT. Methods: Patients (Pts) had TanyN+ or T3-4NanyM0 esophageal and Siewert Type I-III GEJ adenocarcinoma staged by EUS, PET/CT and CT. Pts received mFOLFOX6 ×2 prior to repeat PET/CT. PET responders (PETr) received 5-FU or capecitabine and oxaliplatin with RT to 50.4Gy, while induction PET non-responders (PETnr) received carboplatin/paclitaxel with RT. All Pts received D 1,500 mg q4W ×2 starting 2 wks prior to and during CRT. Esophagectomy wa
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Chen, Xiaobao, Jiang Wei, Ruoyun Xie, and Huaiying Zheng. "Intravesical gemcitabine and docetaxel combined with intravenous tislelizumab as a durable strategy for high-risk non–muscle-invasive bladder cancer." Journal of Clinical Oncology 43, no. 5_suppl (2025): 703. https://doi.org/10.1200/jco.2025.43.5_suppl.703.

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703 Background: For decades, intravesical Bacillus Calmette-Guérin (BCG) has been the standard treatment for high-risk non-muscle-invasive bladder cancer (HR NMIBC). However, its poor tolerability and limited availability underscore the urgent need for more effective therapies. Intravesical sequential gemcitabine and docetaxel (GemDoce) has demonstrated efficacy in HR NMIBC, and immune checkpoint inhibitors (ICIs) have shown effectiveness as second-line therapy for patients with BCG-unresponsive NMIBC. Nevertheless, the combination of immunotherapy with intravesical GemDoce has not yet been re
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Sahu, Kamal Kant, Ajay Mishra, Susan V. George, George Abraham, and Ahmad Daniyal Siddiqui. "Analyzing the outcome of clostridium difficile infection in cancer patients." Journal of Clinical Oncology 38, no. 15_suppl (2020): e19340-e19340. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e19340.

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e19340 Background: Clostridium difficile infection (CDI) is a considerable health burden, and now identified as the leading cause of acquired diarrhea in patients receiving antibiotics. Cancer patients are more prone to acquire CDI, owing to their frequent exposure to risk factors. This study aims to investigate the factors affecting the outcome of Clostridium Difficile Infection in patients with cancer at our community center. Methods: This is a retrospective study that included a total of 59 cancer patients who were hospitalized for clostridium difficile infection. Results: The median age of
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Siada, Sammy, Emily A. Malgor, Mohammed Al-Musawi, Stefanos Giannopoulos, Donald L. Jacobs, and Rafael D. Malgor. "Iliac Artery Endoconduits Should be the Preferred Adjunctive Access Procedure to Facilitate Complex Endovascular Aortic Aneurysm Repair." Vascular and Endovascular Surgery 56, no. 4 (2022): 376–84. http://dx.doi.org/10.1177/15385744211037616.

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Background Iliac artery anatomy can have a dramatic impact on the success of endovascular complex aortic aneurysm (CAA) procedures as endograft delivery systems need to be advanced and manipulated through these access vessels. The aim of this study was to evaluate the outcomes of iliac artery conduits with emphasizes on open vs endovascular conduits performed to facilitate CAA endovascular repair. Methods All patients who had open or endovascular iliac conduits prior to endovascular CAA repair to treat thoracoabdominal, juxtarenal, or suprarenal aneurysms at the University of Colorado Hospital
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48

Yachad, N., and K. D. Naidoo. "Pharmacological management of post-traumatic seizures in a South African paediatric intensive care unit." Southern African Journal of Critical Care 38, no. 1 (2022): 44–49. http://dx.doi.org/10.7196/sajcc.2022.v38i1.522.

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Background. Traumatic brain injury (TBI) is a common cause of paediatric intensive care unit (PICU) admissions in South Africa. Optimal care of these patients includes the prevention and control of post-traumatic seizures (PTS) in order to minimise secondary brain injury. Objectives. To describe the demographics of children admitted to a South African PICU, to describe the characteristics of PTS, and to describe the prophylactic and therapeutic management of PTS within the unit. Method. A 3-year retrospective chart review was conducted at the PICU of the Chris Hani Baragwanath Academic Hospita
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Leis, Jose F., Abby Newton, Mary T. Post, Brandon M. Hayes-Lattin, Richard Thomas Maziarz, and Randy A. Taplitz. "Vancomycin-Resistant Enterococcus (VRE) Colonization Is Associated with a High Rate of Bacteremia and Early Mortality in Transplant/Leukemia Patients." Blood 108, no. 11 (2006): 5315. http://dx.doi.org/10.1182/blood.v108.11.5315.5315.

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Abstract Background: Vancomycin-resistant enterococci (VRE) have become increasingly important nosocomial pathogens in very ill and immunocompromised hospitalized patients (pts). Due to an increase in VRE clinical cultures including bacteremias on our institutional transplant/leukemia service in early 2004, active surveillance for VRE among this population was instituted in June 2004. We describe here the incidence and prevalence of VRE colonization and infection in this population over a two year study period, as well as selected pt demographics and mortality associated with VRE bacteremia. M
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Begum, Taslima, Gulshan Ara Begum, Mahmood A. Chowdhury, Wazir Ahmed, and Md Badrudddoza. "Neonatal Outcomes of Large-for-Gestational Age Infants with or without Gestational Diabetes Mellitus." Chattagram Maa-O-Shishu Hospital Medical College Journal 16, no. 2 (2018): 25–30. http://dx.doi.org/10.3329/cmoshmcj.v16i2.37289.

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Background: Infants are considered Large for Gestational Age (LGA)if their birth weight is greater than the 90th percentile for gestational age. Birth weight is influenced by a number of factors with maternal diabetes being one of the most common risk factor affecting birth weight. They have an increased risk for adverse perinatal outcomes. The aim of the present study was to compare the neonatal outcomes of LGA infants delivered by women with and without gestational diabetes mellitus.Methods: This is a prospective study of all live-born LGA infants of 37 weeks of gestation with a birth weight
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