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1

Blanchette, Robert A., John R. Obst, John I. Hedges, and Karen Weliky. "Resistance of hardwood vessels to degradation by white rot Basidiomycetes." Canadian Journal of Botany 66, no. 9 (1988): 1841–47. http://dx.doi.org/10.1139/b88-251.

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White stringy rot, an unusual type of selective fungal decay, can be found in wood of some dicotyledonous angiosperms. Stages of advanced decay consist of a mass of vessel elements with only remnants of other cells adhering to the vessel walls. Degradation by various white rot Basidiomycetes causes loss of fibers, fiber tracheids, and parenchyma cells but not vessels. In wood of Acacia koa var. koa with a white pocket rot caused by Phellinus kawakamii, fibers and parenchyma cells were preferentially delignified. After extensive lignin removal the cellulose remaining in the secondary wall was d
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2

Adaskaveg, J. E., R. L. Gilbertson, and R. A. Blanchette. "Phellinus ralunensis (aphyllophorales: Hymenochaetaceae), a new white pocket rot species from Chile." Mycological Research 95, no. 7 (1991): 769–75. http://dx.doi.org/10.1016/s0953-7562(09)80036-1.

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3

Zarzyński, Paweł. "Trophic range of Heterobasidion annosum (FR.) Bref. and Phellinus pini (Brot.) Bondartsev & Singer examined in laboratory conditions." Folia Forestalia Polonica, Series A - Forestry 51(2) (July 11, 2009): 145–53. https://doi.org/10.5281/zenodo.30888.

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In this paper the results of laboratory investigation on the range of wood decay caused by Heterobasidion annosum (Fr.) Bref. and Phellinus pini (Brot.) Bondartsev & Singer are described. Wood samples obtained from 25 different, both European and exotic tree species were used as the experimental substrate. The wood samples were exposed to mycelia of tested fungi for 30, 60 and 90 days, and subsequently the loss of their weight was assessed. The results showed a range of trophic preferences of H. annosum and P. pini. Better understanding of these processes could be useful in development of
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4

Fodor, Fanni, Miklós Bak, András Bidló, Bernadett Bolodár-Varga, and Róbert Németh. "Biological Durability of Acetylated Hornbeam Wood with Soil Contact in Hungary." Forests 13, no. 7 (2022): 1003. http://dx.doi.org/10.3390/f13071003.

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This test aimed to discover if industrially acetylated hornbeam can tolerate real-field conditions in Hungary, where various microorganisms can attack the wood separately or cooperatively. Untreated samples accompanied the modified wood to assess the degradation capacity of the soil. The test also focused on weather parameters, the Scheffer index, and soil properties. The untreated stakes showed insect damage, soft rot decay, white rot decay, wasp stripping, moss, and cracks. All of the beech and hornbeam stakes broke after 3.5 years, and the last Scots pine sapwood stakes broke after 6 years.
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Sánchez-Ruiz, María Isabel, Iván Ayuso-Fernández, Jorge Rencoret, et al. "Agaricales Mushroom Lignin Peroxidase: From Structure–Function to Degradative Capabilities." Antioxidants 10, no. 9 (2021): 1446. http://dx.doi.org/10.3390/antiox10091446.

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Lignin biodegradation has been extensively studied in white-rot fungi, which largely belong to order Polyporales. Among the enzymes that wood-rotting polypores secrete, lignin peroxidases (LiPs) have been labeled as the most efficient. Here, we characterize a similar enzyme (ApeLiP) from a fungus of the order Agaricales (with ~13,000 described species), the soil-inhabiting mushroom Agrocybe pediades. X-ray crystallography revealed that ApeLiP is structurally related to Polyporales LiPs, with a conserved heme-pocket and a solvent-exposed tryptophan. Its biochemical characterization shows that A
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6

Ayala Schimpf, Alan Rolando, Laura Ester Ortellado, Marcelo Daniel Gamarra, María Isabel Fonseca, and Pedro Darío Zapata. "In Vitro and Computational Response of Differential Catalysis by Phlebia brevispora BAFC 633 Laccase in Interaction with 2,4-D and Chlorpyrifos." International Journal of Molecular Sciences 25, no. 23 (2024): 12527. http://dx.doi.org/10.3390/ijms252312527.

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Enzymes secreted by white rot fungi (WRF), such as laccase, offer a promising approach for the treatment of hazardous xenobiotic compounds. This study conducted a comprehensive analysis of the impact of the pesticides 2,4-dichlorophenoxyacetic acid (2,4-D) and chlorpyrifos on the laccase of Phlebia brevispora BAFC 633 through in vitro and bioinformatics analyses. The fungal strain was shown to be tolerant to both pesticides, with notable morphological and ultrastructural alterations in the mycelium. Laccase activity and two isoenzymes (53 and 70 kDa) were detected in all initial treatments. Th
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Lockman, B., S. Mascheretti, S. Schechter, and M. Garbelotto. "A First Generation Heterobasidion Hybrid Discovered in Larix lyalli in Montana." Plant Disease 98, no. 7 (2014): 1003. http://dx.doi.org/10.1094/pdis-12-13-1211-pdn.

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On September 25, 2010, a wood sample was collected from an entirely decayed root ball of an alpine larch (Larix lyallii Parl.), 10 cm in diameter at breast height, recently downed, but still green. No attempts were made to determine whether the decay progressed into the stem. The discovery occurred in a stand in the Bitterroot Mountains, south of Darby, Montana (elev. 2,530 m; 45.893528° N, 114.278322° W). Several adjacent alpine larches were either dead or displayed thin crowns, and an old Heterobasidion basidiocarp was found on the decayed root ball of a neighboring dead tree, suggesting the
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8

Sigrist, Marie-Hélène Prince, and Daniel Job. "Études mycologique, entomologique et physico-chimique de troncs de Betula pendula en voie de dégradation. I. Répartition spatiale de l'état physico-chimique et de la mycoflore des troncs." Canadian Journal of Botany 74, no. 10 (1996): 1657–64. http://dx.doi.org/10.1139/b96-201.

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Decaying Betula pendula Roth trunks (measuring about 6 m in length) with brown rot or white rot were analyzed for the followings: stage of decay, wood structure, porosity, chemical composition of decayed wood, spatial distribution of fungal biomass, and mycoflora diversity. The fungal biomass in the trunks, although heterogeneous, is higher in white rot than in brown rot. As expected, the lignin/holocellulose ratio is higher in brown rot than in white rot (maximum 14.83 versus 0.67). Brown rot is generally more porous than white rot and presents a higher water absorption capacity but it retain
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9

Knudsen, E. S., and J. Y. Wang. "Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation." Molecular and Cellular Biology 17, no. 10 (1997): 5771–83. http://dx.doi.org/10.1128/mcb.17.10.5771.

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The growth suppression function of RB is dependent on its protein binding activity. RB contains at least three distinct protein binding functions: (i) the A/B pocket, which binds proteins with the LXCXE motif; (ii) the C pocket, which binds the c-Abl tyrosine kinase; and (iii) the large A/B pocket, which binds the E2F family of transcription factors. Phosphorylation of RB, which is catalyzed by cyclin-dependent protein kinases, inhibits all three protein binding activities. We have previously shown that LXCXE binding is inactivated by the phosphorylation of two threonines (Thr821 and Thr826),
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10

Tarnasky, Aaron, George Nhat Tran, Jonathan Nicolla, et al. "A randomized controlled trial (RCT) testing a mobile application (app) to identify cancer treatment-related financial assistance." Journal of Clinical Oncology 38, no. 15_suppl (2020): 7073. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.7073.

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7073 Background: Insured cancer patients face high treatment-related, out-of-pocket costs. While philanthropic- and pharmaceutical-sponsored financial assistance programs exist, patients are often unaware of them. We developed “Bridge”, a patient-facing app that identified financial assistance programs for which a patient might be eligible based on treatment, disease, insurance, and financial characteristics. We hypothesized that patients in the Bridge study arm would be more likely than controls to apply for and receive financial assistance. Methods: We enrolled patients at a single instituti
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11

Balaji, Thodur Madapusi, Saranya Varadarajan, Raghunathan Jagannathan, et al. "Melatonin as a Topical/Systemic Formulation for the Management of Periodontitis: A Systematic Review." Materials 14, no. 9 (2021): 2417. http://dx.doi.org/10.3390/ma14092417.

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Objectives: To qualitatively and quantitatively review the use of melatonin as a topical/systemic formulation for the management of periodontitis. Materials and methods: PubMed; Scopus; and Web of Science databases were searched using the MesH terms “melatonin” and “periodontitis”. Title and abstracts were screened to eliminate irrelevant and duplicate articles. The full text data of the screened articles were assessed using the selection criteria. Results: Of 176 identified articles (PubMed-66; Scopus-56; Web of Science-52; Cross-reference-2), only 12 studies qualified to be included in the s
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Perez Diaz, Noelia, Lisa A. Lione, Victoria Hutter та Louise S. Mackenzie. "Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery". International Journal of Molecular Sciences 22, № 6 (2021): 3158. http://dx.doi.org/10.3390/ijms22063158.

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Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepancies in understanding the complex role of PPARβ/δ in disease, having both anti- and pro-effects on inflammation. After ligand activation, PPARβ/δ regulates genes by two different mechanisms; induction and transrepression, the effects of which are difficult to differentiate directly. We studied the PPARβ/δ-regulation of lipopolysaccharide (LPS) induced inflammation (indicated by release of nitrite and IL-6) of rat
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13

Basnet, Bhupendra Kumar, Balram Gautam, Kamal Ranabhat, et al. "KRAS Oncogene Mutations in Colorectal Cancer Patients in a Nepalese Tertiary Care Hospital." Journal of Nepal Health Research Council 19, no. 03 (2021): 504–7. http://dx.doi.org/10.33314/jnhrc.v19i3.3421.

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Background: Colorectal cancer is one of the most common cancers in the world and ranks among top ten cancer in Nepal. Limited data have been reported in the literature regarding the prevalence of Kristen Rat Sarcoma viral oncogene mutation in Nepalese patients with colorectal cancer. In a low income country such as Nepal where majority of cancer patient pay for treatment out-of-pocket, it is important to ascertain Kristen Rat Sarcoma viral oncogene mutation status before starting treatment with these agents.Methods: We analysed 22 colorectal cancer specimens diagnosed histopathologically. Real
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14

Muzioł, T., V. Cody, and A. Wojtczak. "Comparison of binding interactions of dibromoflavonoids with transthyretin." Acta Biochimica Polonica 48, no. 4 (2001): 885–92. http://dx.doi.org/10.18388/abp.2001_3854.

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The crystal structure of rat transthyretin (rTTR) complex with the dibromoflavone EMD21388 was determined to 2.3 A resolution and refined to R = 0.203 and Rfree = 0.288. Two different orientations of EMD21388, which differ in the channel penetration by 1.6 A, were found in the A/C binding site of rTTR. The single ligand position observed in the BID site is intermediate between the two positions found in the A/C site. The position of the dibromoflavone in the B/D site is similar to that reported for dibromoaurone in human TTR. The bromine atoms of EMD21388 form strong interactions in the P3 and
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15

Garbelotto, M., and I. Chapela. "First Report of Heterobasidion annosum on the Endemic Abies hickeli of Southern Mexico." Plant Disease 84, no. 9 (2000): 1047. http://dx.doi.org/10.1094/pdis.2000.84.9.1047b.

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The basidiomycete Heterobasidion annosum (Fr.:Fr.) Bref. is a pathogen of conifers in the Northern Hemisphere. This fungus has been previously reported from Pinus spp. (1) and from Abies religiosa (H.B.K.) Schl. et Cham. (2) in Central Mexico. In 1998, H. annosum was collected for the first time from stumps of Abies hickeli Flous et Gaussen in the Southern Mexican State of Oaxaca, at an altitude of 2,900 m (Lat 17° 28′ N, Long 96° 31′ W). Although standing trees at the sampled site were asymptomatic, the sapwood and heartwood of several fir stumps were extensively decayed. The white laminated
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16

Khanna, Anchit, Hannah Small, Dhamend Lutchman, and Peter Schofield. "ASC4REAL: Efficacy and tolerability comparison between ASCEMBL study, a phase 3 randomized clinical trial (RCT), and consolidated real-world (RW) experience with asciminib (ASC) in patients with CML beyond two TKIs." Journal of Clinical Oncology 42, no. 16_suppl (2024): e18519-e18519. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e18519.

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e18519 Background: Despite advances in the management of chronic myeloid leukemia (CML), effective treatment options in later lines are limited. Treatment failure rates increase with each line of treatment and sequential tyrosine kinase inhibitor (TKI) therapy is associated with increased resistance. Importantly, almost all TKIs in the clinics target the ATP-binding site potentially resulting in off-target effects and long-term tolerability issues. Although data for ASC, a novel allosteric TKI targeting the myristoyl pocket, is emerging in the RW setting, low patient numbers in ASC RW studies
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17

Bharathwaj, Ananya, Erica Steen, Carla Sampaio, et al. "Atropisomeric pyrrolopyrimidine inhibitor as a targeted approach for RET tyrosine kinase in neuroblastoma." Journal of Clinical Oncology 43, no. 16_suppl (2025): 3118. https://doi.org/10.1200/jco.2025.43.16_suppl.3118.

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3118 Background: Increased RET expression is associated with poor prognosis in children with solid tumors such as neuroblastoma (NB), prompting an interest in RET inhibition. A number of kinase inhibitors currently in use for cancer patients have RET inhibitory activity, but these inhibitors also display activity against other kinases, resulting in unwanted side effects and limiting their safety and efficacy. However, developing more specific RET inhibitors remains a drug design challenge due to high levels of conservation between kinase binding pockets. Using novel chiral chemistry leveraging
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18

Pennell, Nathan A., Lori J. Wirth, Justin F. Gainor, et al. "A first-in-human phase 1 study of the next-generation RET inhibitor, LOXO-260, in RET inhibitor refractory patients with RET-altered cancers (trial in progress)." Journal of Clinical Oncology 40, no. 16_suppl (2022): TPS8595. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.tps8595.

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TPS8595 Background: RET fusions are found in 1-2% of lung adenocarcinomas and 10-20% of papillary thyroid carcinomas. Activating RET mutations occur in 50-60% of medullary thyroid cancers (MTCs). Selpercatinib was the first selective RET inhibitor approved by the FDA and is indicated for patients (pts) with RET fusion-positive NSCLC and thyroid cancer, and RET mutant MTC. Despite marked and durable activity, acquired resistance can eventually develop through a variety of mechanisms. These include acquisition of RET G810X mutations at the solvent front of the ATP pocket. LOXO-260 is a highly po
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19

Cho, Young Joon, Yong Tak Jeong, Hyun Nyun Woo, et al. "Reassessing the Use of Membranes in Peri-Implantitis Surgery: A Systematic Review and Meta-Analysis of In Vivo Studies." Journal of Functional Biomaterials 16, no. 7 (2025): 262. https://doi.org/10.3390/jfb16070262.

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Peri-implantitis (PI) presents a growing challenge in implant dentistry, with regenerative surgical approaches often incorporating barrier membranes despite the uncertainty of their clinical value. This systematic review and meta-analysis of in vivo studies aimed to evaluate the efficacy of barrier membranes in the reconstructive surgical treatment of PI. A comprehensive electronic search was performed in PubMed, Scopus, Google Scholar, and the Cochrane Library, covering studies published from 1990 to 2024. The protocol followed PRISMA guidelines and was registered in PROSPERO (CRD42025625417)
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Mori, Graziela Garrido, Ivaldo Gomes de Moraes, Roberto Brandão Garcia, Lilian Cristina Baraldi Borro, and Bruno Rombaldi Purificação. "Microscopic investigation of the use of gallium nitrate for root surface treatment in rat teeth submitted to delayed replantation." Brazilian Dental Journal 18, no. 3 (2007): 198–201. http://dx.doi.org/10.1590/s0103-64402007000300004.

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The aim of this study was to investigate the effect of gallium nitrate solution, an anti-resorption substance, when applied for root surface treatment in rat teeth submitted to delayed replantation, in order to inhibit the root resorption process and enhance repair. For such purpose, 20 maxillary right central incisors of rats were randomly assigned to 2 groups (n=10). In group I, root surface was treated with 10-4M gallium nitrate solution for 20 min, while in group II root surface was treated with 2% sodium fluoride for 20 min. All root canals were filled with a calcium hydroxide-based paste
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21

Gutierrez, Belen, Jose A. Escudero, Alvaro San Millan, et al. "Fitness Cost and Interference of Arm/Rmt Aminoglycoside Resistance with the RsmF Housekeeping Methyltransferases." Antimicrobial Agents and Chemotherapy 56, no. 5 (2012): 2335–41. http://dx.doi.org/10.1128/aac.06066-11.

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ABSTRACTArm/Rmt methyltransferases have emerged recently in pathogenic bacteria as enzymes that confer high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the G1405 residue in the 16S rRNA (like ArmA and RmtA to -E). In prokaryotes, nucleotide methylations are the most common type of rRNA modification, and they are introduced posttranscriptionally by a variety of site-specific housekeeping enzymes to optimize ribosomal function. Here we show that while the aminoglycoside resistance methyltransferase RmtC methylates G1405, it impedes methylation of the housekeeping
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22

Schlee, Markus, Hom-Lay Wang, Thomas Stumpf, Urs Brodbeck, Dieter Bosshardt, and Florian Rathe. "Treatment of Periimplantitis with Electrolytic Cleaning versus Mechanical and Electrolytic Cleaning: 18-Month Results from a Randomized Controlled Clinical Trial." Journal of Clinical Medicine 10, no. 16 (2021): 3475. http://dx.doi.org/10.3390/jcm10163475.

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Aim of the study: This RCT assesses patients’ 18-month clinical outcomes after the regenerative therapy of periimplantitis lesions using either an electrolytic method (EC) to remove biofilms or a combination of powder spray and an electrolytic method (PEC). Materials and Methods: Twenty-four patients (24 implants) suffering from periimplantitis were randomly treated by EC or PEC followed by augmentation and submerged healing. Probing pocket depth (PPD), Bleeding on Probing (BoP), suppuration, and standardized radiographs were assessed before surgery (T0), 6 months after augmentation (T1), and
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23

Kotler, Burt P., Joel S. Brown, Sonny S. Bleicher, and Keren Embar. "Intercontinental-wide consequences of compromise-breaking adaptations: the case of desert rodents." Israel Journal of Ecology and Evolution 62, no. 3-4 (2016): 186–95. http://dx.doi.org/10.1080/15659801.2015.1125832.

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Desert rodent assemblages from around the world provide convergent, but independent crucibles for testing theory and deducing general ecological principles. The heteromyid rodents of North America and the gerbils of the Middle East and their predators provide such an example. Both sets of rodents face predation from owls and vipers, but the North American species possess unique traits that may represent macroevolutionary breakthroughs: rattlesnakes have infra-red sensitive sensory pits, and heteromyids have cheek pouches. To test their significance, we brought together two gerbils (Middle East
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24

Makino, Koji, Mia Mudge, Chelsea Zaunmayr, and Dom Tilden. "PP41 Using Medicare Claims Data To Support Reimbursement Of A Novel Leadless Pacing System For The Management Of Bradycardia." International Journal of Technology Assessment in Health Care 39, S1 (2023): S63. http://dx.doi.org/10.1017/s0266462323001897.

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IntroductionThe Micra Transcatheter Pacing System (Micra TPS) is a single-chamber transcatheter leadless pacemaker (LPM). LPMs do not require leads or a subcutaneous pocket, which represent the primary sources of device-related complications with conventional transvenous pacemakers (TVPMs). Complications such as infections and lead dislodgements cause significant patient burden, which have significant economic consequences. Running a randomized controlled trial (RCT) to estimate risk differences of infrequent events requires large sample sizes and long follow-up periods. Real-world observation
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25

Kodir, Ade Ismail Abdul, Muhamat Muhtar S. Abdurrohman, and Talitha Novi Rahmaningrum. "THE EFFECT OF PERIODONTAL PACK WITH ADDITIONAL PLANTS OF IODINE (JATROPHA MULTIFIDA L.) POST CURRETAGE." Jurnal Medali 4, no. 2 (2022): 104. http://dx.doi.org/10.30659/medali.4.2.104-109.

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Background: Curettage is an act of scraping the granulation tissue on the lateral gingival wall of the periodontal pocket. After curettage, a periodontal pack was applied to control bleeding and keep the wound area clean. The addition of iodine leaves as an alternative because it contains flavonoids that can help the wound healing process. This study aims to determine the effect of adding 10% iodine leaf extract gel on the curettage process.Method: A true experimental laboratory study with a post-test only control group design on 20 wistar rats. The periodontal pack group and the periodontal p
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Ashifa, Nisha, Krishnan Viswanathan, Sivapragasam Srinivasan, et al. "Clinical effectiveness of aloe vera gel as an adjunct to mechanical debridement in patients with periodontitis: A systematic review and meta-analysis." Journal of Advanced Periodontology & Implant Dentistry 17, no. 1 (2025): 15–25. https://doi.org/10.34172/japid.2025.002.

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Background. This study aimed to evaluate the clinical effect of aloe vera gel as an adjunct to scaling and root planing (SRP) on plaque index (PI), gingival index (GI), and probing pocket depth (PPD) in periodontitis treatment. Methods. Randomized controlled trials (RCTs) were included, focusing on aloe vera gel as an adjunct to SRP in periodontitis patients. An extensive literature search was conducted across PubMed, PubMed Central, Scopus, OVID, Google Scholar, and Cochrane Library databases up to October 2024. The risk of bias was assessed using the Revised Cochrane Risk of Bias tool (ROB 2
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Galbraith, Alison A., Elena Faugno, Lauren A. Cripps, Kathryn M. Przywara, Davene R. Wright, and Melissa B. Gilkey. "“You Have to Rob Peter to Pay Paul So Your Kid Can Breathe”." Medical Care 61, no. 12 (2023): S95—S103. http://dx.doi.org/10.1097/mlr.0000000000001914.

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Background: Economic analyses often focus narrowly on individual patients’ health care use, while overlooking the growing economic burden of out-of-pocket costs for health care on other family medical and household needs. Objective: The aim of this study was to explore intrafamilial trade-offs families make when paying for asthma care. Research Design: In 2018, we conducted telephone interviews with 59 commercially insured adults who had asthma and/or had a child with asthma. We analyzed data qualitatively via thematic content analysis. Participants: Our purposive sample included participants
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Arampatzis, Spyridon, Bert Kadereit, Daniela Schuster та ін. "Comparative enzymology of 11β-hydroxysteroid dehydrogenase type 1 from six species". Journal of Molecular Endocrinology 35, № 1 (2005): 89–101. http://dx.doi.org/10.1677/jme.1.01736.

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11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1), catalyzing the intracellular activation of cortisone to cortisol, is currently considered a promising target to treat patients with metabolic syndrome; hence, there is considerable interest in the development of selective inhibitors. For preclinical tests of such inhibitors, the characteristics of 11β-HSD1 from the commonly used species have to be known. Therefore, we determined differences in substrate affinity and inhibitor effects for 11β-HSD1 from six species. The differences in catalytic activities with cortisone and 11-dehydrocorticoste
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Lestari, Citra, Eryati Darwin, Deddi Prima Putra та Netti Suharti. "The α-mangostin effect on the quantity of TGF-β1 titer relate to the mandibular bone volume of Rattus novergicus in the periodontitis model". Journal of Pharmacy & Pharmacognosy Research 9, № 5 (2021): 609–18. http://dx.doi.org/10.56499/jppres21.1015_9.5.609.

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Context: Periodontitis causes pocket formation, gingival recession, and destruction of periodontal ligaments and alveolar bone. Periodontitis disturbs the attachment of periodontal ligaments to the maxillary and mandibular bones. The α-mangostin has shown role-playing in the bone remodeling process. Aims: To evaluate the potential of α-mangostin induce the TGFβ1 titer associated with the increased mandibular bone volume on the alveolar bone remodeling of periodontitis of Rattus novergicus. Methods: The α-mangostin used to the single administration dosage on the rat periodontitis model on the 7
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Rashid, Zahid, and Matthias Rötting. "Evaluation of Manual Skill Degradation Due to Automation in Apparel Manufacturing." Applied Sciences 11, no. 23 (2021): 11098. http://dx.doi.org/10.3390/app112311098.

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Manual skill degradation is a common problem that production managers face in assembly lines due to frequent changes in batch styles. Since the advancement in automated machinery, reliance on manual machines has been reduced. However, due to the high cost of fully automated machinery, it is still not available on a large scale in apparel manufacturing setups as most of the setups are in developing countries. Few related studies regarding the effects of automation on manual skills have been conducted in aviation and other emerging technological advanced fields; little focus was given on the eff
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Vettraino, A. M., S. Franceschini, and A. Vannini. "First Report of Buxus rotundifolia Root and Collar Rot Caused by Phytophthora citrophthora in Italy." Plant Disease 94, no. 2 (2010): 272. http://dx.doi.org/10.1094/pdis-94-2-0272a.

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Boxwood (Buxus spp.) includes several species of popular ornamental shrubs used in traditional and contemporary gardening. In March of 2008, a gradual and irreversible decline was observed on 6-year-old Buxus rotundifolia plants in a garden in central Italy. Of 150 boxwood plants, 70% were symptomatic, and among them, approximately 25% were completely wilted. Aboveground symptoms included stunting, necrotic bark lesions at the base of the stem, reduced growth, and leaf chlorosis. Leaves at first appeared light green, then turned yellow, bronze, or straw colored. Foliar symptoms were restricted
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BALANCO, J. M. F., E. M. F. PRAL, S. da SILVA, A. T. BIJOVSKY, R. A. MORTARA, and S. C. ALFIERI. "Axenic cultivation and partial characterization of Leishmania braziliensis amastigote-like stages." Parasitology 116, no. 2 (1998): 103–13. http://dx.doi.org/10.1017/s003118209700214x.

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Leishmania braziliensis strain M2903 was adapted for growth and serially maintained as amastigotes at 34°C in modified UM-54 medium, with growth curves exhibiting typical log and stationary phases. In late passages, amastigote growth took place in the absence of supplementary haemin and was unaffected when the initial medium pH was adjusted between 5·4 and 6·3. In contrast to promastigotes, which were elongated and exhibited very long free flagella endowed with the paraflagellar rod (PFR), axenic amastigotes were rounded to ovoid and displayed a short flagellum restricted to the pocket area. T
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Khanna, Anchit, Hannah Small, Dhamend Lutchman, et al. "ASC4REAL: Efficacy and Tolerability Comparison between Ascembl Study, a Phase 3 Randomized Clinical Trial (RCT), and Consolidated Real-World (RW) Evidence with Asciminib in CML Patients Beyond 2 TKIs." Blood 144, Supplement 1 (2024): 4527. https://doi.org/10.1182/blood-2024-201022.

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Introduction: Despite advancements in managing chronic myeloid leukemia (CML), there are limited effective treatment options available in later lines of therapy. With each successive line of treatment, the rates of treatment failure increase, and sequential tyrosine kinase inhibitor (TKI) therapy is linked to higher resistance. It is worth noting that most TKIs currently used in clinical practice target the ATP binding site, which may lead to off-target effects and long-term tolerability issues. ASCEMBL is a phase 3 randomized controlled trial (RCT) evaluating the efficacy of asciminib (ASC),
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34

Morgan, Eric R., David Modry, Claudia Paredes-Esquivel, Pilar Foronda, and Donato Traversa. "Angiostrongylosis in Animals and Humans in Europe." Pathogens 10, no. 10 (2021): 1236. http://dx.doi.org/10.3390/pathogens10101236.

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Lungworms in the genus Angiostrongylus cause disease in animals and humans. The spread of Angiostrongylus vasorum within Europe and the recent establishment of Angiostrongylus cantonensis increase the relevance of these species to veterinary and medical practitioners, and to researchers in parasitology, epidemiology, veterinary science and ecology. This review introduces the key members of the genus present in Europe and their impacts on health, and updates the current epidemiological situation. Expansion of A. vasorum from localized pockets to wide distribution across the continent has been c
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35

Tang, Tracy T., and Leonard Post. "Abstract 7282: Comparing TEAD palmitoylation inhibitors with differential TEAD selectivity in combination efficacy with targeted therapies and in renal safety." Cancer Research 84, no. 6_Supplement (2024): 7282. http://dx.doi.org/10.1158/1538-7445.am2024-7282.

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Abstract Genetic alterations of the Hippo signaling pathway components resulting in YAP/TAZ activation have been reported in a variety of human malignancies. YAP/TAZ activation and functional requirement have also been linked to resistance to targeted therapies by providing the essential survival signal in drug-tolerant persister/dormant cells. As the main drivers for YAP/TAZ recruitment to chromatin, TEAD transcription factors are the major effectors of the Hippo-YAP/TAZ pathway involved in the regulation of cell proliferation, survival, and cell migration. There are four members in the TEAD
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36

Yusri, Sarah, Ahmed Elfana, Weam Elbattawy, and Karim M. Fawzy El-Sayed. "Effect of locally delivered adjunctive antibiotics during surgical periodontal therapy: a systematic review and meta-analysis." Clinical Oral Investigations 25, no. 9 (2021): 5127–38. http://dx.doi.org/10.1007/s00784-021-04056-7.

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Abstract Aim The present study aimed to systematically assess current evidence on effects of locally delivered antibiotics during periodontal surgery compared to periodontal surgery alone on clinical attachment level (CAL) gain, probing pocket depth (PPD) reduction, recession depth (RD) changes, gingival index (GI), bleeding on probing (BOP), and plaque index (PI). Methodology MEDLINE-PubMed, Cochrane-CENTRAL and Scopus databases were searched up to April 2021 for randomized clinical trials (RCT), evaluating effects of locally delivered antibiotics during periodontal surgery. CAL gain served a
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Li, Xinyi, Zengxin Qi, Duan Ni, Shaoyong Lu, Liang Chen, and Xiangyu Chen. "Markov State Models and Molecular Dynamics Simulations Provide Understanding of the Nucleotide-Dependent Dimerization-Based Activation of LRRK2 ROC Domain." Molecules 26, no. 18 (2021): 5647. http://dx.doi.org/10.3390/molecules26185647.

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Mutations in leucine-rich repeat kinase 2 (LRRK2) are recognized as the most frequent cause of Parkinson’s disease (PD). As a multidomain ROCO protein, LRRK2 is characterized by the presence of both a Ras-of-complex (ROC) GTPase domain and a kinase domain connected through the C-terminal of an ROC domain (COR). The bienzymatic ROC–COR–kinase catalytic triad indicated the potential role of GTPase domain in regulating kinase activity. However, as a functional GTPase, the detailed intrinsic regulation of the ROC activation cycle remains poorly understood. Here, combining extensive molecular dynam
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De Weggheleire, Anja, Antoine Nkuba-Ndaye, Placide Mbala-Kingebeni, et al. "A Multidisciplinary Investigation of the First Chikungunya Virus Outbreak in Matadi in the Democratic Republic of the Congo." Viruses 13, no. 10 (2021): 1988. http://dx.doi.org/10.3390/v13101988.

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Early March 2019, health authorities of Matadi in the Democratic Republic of the Congo alerted a sudden increase in acute fever/arthralgia cases, prompting an outbreak investigation. We collected surveillance data, clinical data, and laboratory specimens from clinical suspects (for CHIKV-PCR/ELISA, malaria RDT), semi-structured interviews with patients/caregivers about perceptions and health seeking behavior, and mosquito sampling (adult/larvae) for CHIKV-PCR and estimation of infestation levels. The investigations confirmed a large CHIKV outbreak that lasted February–June 2019. The total case
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M, Magesh, and Gandhimathi R. "In-silico Molecular Docking Studies of Methyl Oxadiazole Hybrids Inhibiting Acetylcholinesterase for Alzheimer’s Disease Treatment." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 403–13. http://dx.doi.org/10.25258/ijpqa.15.1.63.

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Memory loss and cognitive decline are the main signs of Alzheimer’s disease (AD), a neurodegenerative brain illness that affects millions worldwide. AD is linked to aberrant beta-amyloid, low acetylcholine, oxidative stress, inflammation, and T protein aggregation. Low acetylcholine levels are one of the most important factors in Alzheimer’s disease since they are essential for cognitive processing and memory. This is why we’ve concentrated on ACHEIs and the cholinergic system. We used in-silico testing to find new and effective oxadiazole acetylcholinesterase inhibitors. This study created, d
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40

Nyiramana, Mukamurera P. "Prevalence and Control of Malaria in Uganda: Epidemiological Trends and Public Health Interventions." Research Output Journal of Public Health and Medicine 3, no. 3 (2024): 52–55. http://dx.doi.org/10.59298/rojphm/2024/335255.

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Malaria is a critical public health issue in Uganda, a country that bears one of the highest burdens of the disease globally. Despite significant advancements in medical treatments and preventive measures, malaria continues to pose a substantial threat to the health and economic well-being of Ugandans. This review provides a comprehensive analysis of the prevalence and control of malaria in Uganda, examining epidemiological trends and assessing the impact of public health interventions. Recent data indicate that while the overall incidence of malaria has declined due to intensified control eff
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ETTI, IMAOBONG, and Esther Uweh. "Small Molecules From Vernonia Amygdalina (Del.) As Promising Agents For Kras-Driven Tumors." Journal of Current Biomedical Research 2, no. 1 (2022): 64–77. http://dx.doi.org/10.54117/jcbr.v2i1.5.

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In spite of advances in medicine, cancer remains the second leading cause of death, accounting for 1 in every 6 deaths globally. Numerous oncogenes have been identified to be constitutively active in cancer due to genetic alterations. A notable and hard-to-hit one is the Kras (Kirsten rat sarcoma). Howbeit, resistance and toxicity from synthetic drugs have reduced the survival rate, causing most cancer patients to seek natural remedies with fewer side-effects as alternatives. This study was conducted to investigate the Kras inhibitory effect of small molecules from Vernonia amygdalina, utilizi
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Alsalamah, Sulaiman A., Mohammed Ibrahim Alghonaim, Mohammed Jusstaniah, and Tarek M. Abdelghany. "Anti-Yeasts, Antioxidant and Healing Properties of Henna Pre-Treated by Moist Heat and Molecular Docking of Its Major Constituents, Chlorogenic and Ellagic Acids, with Candida albicans and Geotrichum candidum Proteins." Life 13, no. 9 (2023): 1839. http://dx.doi.org/10.3390/life13091839.

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Lawsonia inermis, known as henna, has traditionally been utilized in cosmetics and folk medicine because of their valuable health effects. A lack of information about the processes that increase or decrease release, as well as the biological activities of constituents of natural origin, is an important pharmacological problem. This investigation evaluates the influence of moist heat on the flavonoid and phenolic contents of henna powder and their biological activities. HPLC analysis reflected the existence of 20 and 19 compounds of flavonoids and phenolics in the extract of unpre-treated henna
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43

Worthy, T. H., and R. N. Holdaway. "Quaternary fossil faunas, overlapping taphonomies, and palaeofaunal reconstruction in North Canterbury, South Island, New Zealand." Journal of the Royal Society of New Zealand 26, no. 3 (1996): 275–361. https://doi.org/10.5281/zenodo.13515749.

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(Uploaded by Plazi for the Bat Literature Project) Charadrius bicinctus, Thinornis novaeseelandiae, and Sterna albostriata. In these faunas the abundance of two species that live or lived in open shrublands and grasslands, the extinct quail Coturnix novaezelandiae and pipit Anthus novaeseelandiae is positively correlated with the abundance of kiore Rattus exulans in the late Holocene. While quail and pipit dominated the late-Glacial to early Holocene small-bird fauna of Glencrieff indicating the presence of shrubland at that time, these species were virtually absent from the well-represented p
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44

Worthy, T. H., and R. N. Holdaway. "Quaternary fossil faunas, overlapping taphonomies, and palaeofaunal reconstruction in North Canterbury, South Island, New Zealand." Journal of the Royal Society of New Zealand 26, no. 3 (1996): 275–361. https://doi.org/10.5281/zenodo.13515749.

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(Uploaded by Plazi for the Bat Literature Project) Charadrius bicinctus, Thinornis novaeseelandiae, and Sterna albostriata. In these faunas the abundance of two species that live or lived in open shrublands and grasslands, the extinct quail Coturnix novaezelandiae and pipit Anthus novaeseelandiae is positively correlated with the abundance of kiore Rattus exulans in the late Holocene. While quail and pipit dominated the late-Glacial to early Holocene small-bird fauna of Glencrieff indicating the presence of shrubland at that time, these species were virtually absent from the well-represented p
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45

Worthy, T. H., and R. N. Holdaway. "Quaternary fossil faunas, overlapping taphonomies, and palaeofaunal reconstruction in North Canterbury, South Island, New Zealand." Journal of the Royal Society of New Zealand 26, no. 3 (1996): 275–361. https://doi.org/10.5281/zenodo.13515749.

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(Uploaded by Plazi for the Bat Literature Project) Charadrius bicinctus, Thinornis novaeseelandiae, and Sterna albostriata. In these faunas the abundance of two species that live or lived in open shrublands and grasslands, the extinct quail Coturnix novaezelandiae and pipit Anthus novaeseelandiae is positively correlated with the abundance of kiore Rattus exulans in the late Holocene. While quail and pipit dominated the late-Glacial to early Holocene small-bird fauna of Glencrieff indicating the presence of shrubland at that time, these species were virtually absent from the well-represented p
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46

Worthy, T. H., and R. N. Holdaway. "Quaternary fossil faunas, overlapping taphonomies, and palaeofaunal reconstruction in North Canterbury, South Island, New Zealand." Journal of the Royal Society of New Zealand 26, no. 3 (1996): 275–361. https://doi.org/10.5281/zenodo.13515749.

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(Uploaded by Plazi for the Bat Literature Project) Charadrius bicinctus, Thinornis novaeseelandiae, and Sterna albostriata. In these faunas the abundance of two species that live or lived in open shrublands and grasslands, the extinct quail Coturnix novaezelandiae and pipit Anthus novaeseelandiae is positively correlated with the abundance of kiore Rattus exulans in the late Holocene. While quail and pipit dominated the late-Glacial to early Holocene small-bird fauna of Glencrieff indicating the presence of shrubland at that time, these species were virtually absent from the well-represented p
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47

Iheagwam, Franklyn Nonso, Gaber El-Saber Batiha, Olubanke Olujoke Ogunlana, and Shalom Nwodo Chinedu. "Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene." International Journal of Inflammation 2021 (December 16, 2021): 1–16. http://dx.doi.org/10.1155/2021/9778486.

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This study aims at evaluating the ameliorative role of Terminalia catappa aqueous leaf extract (TCA) on hyperglycaemia-induced oxidative stress and inflammation in a high-fat, low dose streptozotocin-induced type 2 diabetic rat model. Experimental rats were treated orally with 400 and 800 mg/kg bw TCA daily for four weeks. Antioxidant enzyme activities, plasma glucose concentration, protein concentration, oxidative stress, and inflammation biomarkers were assayed using standard methods. Hepatic relative expressions of tumour necrosis factor-alpha (TNF-α), interleukin-six (IL-6), and nuclear fa
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48

Jin, Wenqin, Lingfeng Li, Huangping Ai, Zhao Jin, and Yuling Zuo. "Efficacy and Safety of Traditional Chinese Medicine Based on the Method of “Nourishing Kidney and Clearing Heat” as Adjuvant in the Treatment of Diabetes Mellitus Patients with Periodontitis: A Systematic Review and Meta-Analysis." Evidence-Based Complementary and Alternative Medicine 2022 (August 27, 2022): 1–12. http://dx.doi.org/10.1155/2022/3853303.

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Objective. The aim of this systematic review and meta-analysis was to assess the efficacy and safety of traditional Chinese medicine based on the method of “nourishing kidney and clearing heat” as an adjuvant in the treatment of diabetes mellitus patients with periodontitis. Methods. An electronic literature search was conducted in the China National Knowledge Infrastructure (CNKI), Wanfang Data, Chinese Scientific Journals Database (VIP), Chinese Biomedical Literature Database (CBM), PubMed, EMBASE, Web of Science, and Cochrane Library databases for articles published until October 2021. The
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Liu, Beibei, an Li, Xiangyang Zuo, et al. "Abstract 4984: Integrated platform enables KRAS-targeted drugs discovery." Cancer Research 83, no. 7_Supplement (2023): 4984. http://dx.doi.org/10.1158/1538-7445.am2023-4984.

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Abstract The Kirsten rat sarcoma viral oncogene homolog (KRAS) is mutated in approximately 25% of all human cancers and is known to be a major player promoting and maintaining tumorigenesis through the RAS-MAPK pathway. Activating mutations in KRAS increase the ability for GTP-loading, making it difficult to displace, thus constitutively activate downstream MAPK pathway and promote cancer formation. Fortunately, a revolutionary strategy to use covalent allosteric inhibitors that target a shallow pocket on the KRAS surface has provided new impetus for KRAS inhibitor development efforts. These i
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Liu, Suxing, Weimin Hu, Dexiao Yang, et al. "Discovery of BTC-86, a Novel Second-Generation Menin-MLL Inhibitor to Overcome the Acquired Resistance in MEN1 for R/R Acute Leukemia." Blood 144, Supplement 1 (2024): 3586. https://doi.org/10.1182/blood-2024-202042.

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The menin-MLL1 interaction is essential for acute leukemias driven by MLL rearrangements (MLLr) or mutations in the nucleophosmin 1 gene (NPM1c). Menin-MLL inhibitor SNDX-5613 (revumenib) has demonstrated robust clinical responses in the clinical trial. However, somatic MEN1 mutations were found at residues M327, G331 or T349 at the revumenib-menin interface in the patients with acquired resistance to menin inhibition and post a major challenge to the management of acute leukemias driven by MLLr or NPM1c. Therefore, developing second-generation inhibitors that block MLL1 binding while having a
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