To see the other types of publications on this topic, follow the link: WHO-5 criteria.
Journal articles on the topic 'WHO-5 criteria'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'WHO-5 criteria.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Shital, A. Patel, and Jasani Kena. "EFFECT OF DIFFERENT FORMS OF EXERCISE ON MENTAL WELL BEING." International Journal of Basic and Applied Physiology 7, no. 1 (2018): 61–65. https://doi.org/10.5281/zenodo.4481423.
Full textAbstract:
Background: Exercises in different forms, if performed regularly, have a beneficial effect on the various systems of the body. Yoga has been studied and found to have positive effects on physical fitness, mood, anxiety level, and cognitive functioning. This study is being under taken to find out the effect of exercises of different forms like swimming and yoga on mental well being and concentration of the subject and to find out the difference between benefits gained by yoga and swimming. Objective: To study effects of Yoga and Swimming on mental wellbeing and concentration of subjects and compare the benefits gained by yoga and swimming practice. Method: It was a cross-sectional study. Total of 90 subjects were included in study after taking prior written informed consent. 30 subjects were practising yoga regularly and 30 subjects were swimming regularly for minimum of 6 weeks. 30 subjects were not practising any form exercise. Mental well being assessment was done with help of WHO-5 criteria and concentration level was assessed by Letter cancellation task. Data was analyzed & frequency table was prepared with help of SPSS 13 software. Results & Discussion: WHO-5 criteria for mental well being mean score was more in yoga group subjects (21.37+2.456) and swimming group subjects(21.20+4.139) than of non exercising group subjects(18.33+3.367). Also mean score of yoga group was higher than swimming group. Difference between swimming and non-exercising groups was statistically significant. Difference between Yoga and non-exercising groups was statistically highly significant (P<0.0001). Letter cancellation task results were higher in yoga group subjects (70+13.17) than non exercising group subjects (58.83+12.93). Difference was statistically significant. Mean scores were higher in yoga and swimming group subjects than in non-exercising subjects. Conclusion: Results of this study suggest that regular exercise in any form like aerobic endurance exercise or yoga can bring definitive significant improvement in mood and concentration and overall mental well-being. Changing sedentary habits and replacing it with more active physical behaviour in form of either exercise like swimming, jogging, cycling or practice of Yoga will reduces the occurrence of mental health diseases like depression, anxiety, suicidal tendency, etc.
2
Khan, Uzma, Suman Nishad, Shweta Kumari, Ayesha Ahmad, Fareha Khatoon, and Aalami Zeba. "CESAREAN SECTION INDICATIONS USING MODIFIED ROBSON’S CRITERIA." Era's Journal of Medical Research 10, no. 01 (2023): 19–24. http://dx.doi.org/10.24041/ejmr2023.3.
Full textAbstract:
Cesarean section (CS) is increasingly replacing vaginal delivery, which is concerning due to associated complications. World Health Organization (WHO) recommends robust classification such as Modified Robson's criteria for decision making to minimise non indicated CS. This study was planned to see the applicability of Modified Robson's criteria in assessing causes of CS. To classify and compare indications of CS using the WHO modified Robson’s criteria. The present study was a retrospective study conducted at Era's Lucknow Medical College over 24 months. Due approval was obtained from ethics committee before commencing the study. All cases who underwent CS from 1st January 2018 to 31st December 2019 were analysed, data classified in accordance with the WHO Modified Robson's criteria and analysed. Parameters used for analysis included gestational age, parity, number of foetuses, history of previous CS, fetal lie and presentation, induced or spontaneous labour, indication of CS and any associated high risk factors. Of 1929 deliveries, 621(32.2%) had CS. A total 500 CS were evaluated. The major contributor to overall CS rate was Group 5 [30%], 10 [17.4%] and 1 [16.4%]. Modified Robson's classification could be easily applied to our data set and helped in identification of the main groups which contributed majorly to the overall CS rate viz. previous CS, nulliparity, prematurity and induced labours. It also helped us in identifying the subgroups which require more surveillance and monitoring. It is important to focus on Group 5, 10 and 1 which constitute 63.8% of total CS being done.
3
Linton, Kristen Faye, Taylor E. Krcek, Leonard M. Sensui, and Jessica L. H. Spillers. "Opinions of People Who Self-Identify With Autism and Asperger’s on DSM-5 Criteria." Research on Social Work Practice 24, no. 1 (2013): 67–77. http://dx.doi.org/10.1177/1049731513495457.
Full text
4
Santos-García, D., T. de Deus Fonticoba, E. Suárez Castro, A. Aneiros Díaz, and D. McAfee. "5-2-1 Criteria: A Simple Screening Tool for Identifying Advanced PD Patients Who Need an Optimization of Parkinson’s Treatment." Parkinson's Disease 2020 (March 24, 2020): 1–6. http://dx.doi.org/10.1155/2020/7537924.
Full textAbstract:
Objective. 5- (5 times oral levodopa tablet taken/day) 2- (2 hours of OFF time/day) 1- (1 hour/day of troublesome dyskinesia) criteria have been proposed by a Delphi expert consensus panel for diagnosing advanced Parkinson’s disease (PD). The aim of the present study is to compare quality of life (QoL) in PD patients with “5-2-1 positive criteria” vs QoL in PD patients without “5-2-1 positive criteria” (defined as meeting ≥1 of the criteria). Methods. This is a cross-sectional, observational, monocenter study. Three different instruments were used to assess QoL: the 39-Item Parkinson’s Disease Quality of Life Questionnaire Summary Index Score (PDQ-39SI); a subjective rating of perceived QoL (PQ-10); and the EUROHIS-QOL 8-Item Index (EUROHIS-QOL8). Results. From a cohort of 102 PD patients (65.4 ± 8.2 years old, 53.9% males; disease duration 4.7 ± 4.5 years), 20 (19.6%) presented positive 5-2-1 criteria: 6.9% for 5, 17.6% for 2, and 4.9% for 1. 37.5% (12/32) and 25% (5/20) of patients with motor complications and dyskinesia, respectively, presented 5-2-1 negative criteria. Both health-related (PDQ-39SI, 25.6 ± 14 vs 12.1 ± 9.2; p<0.0001) and global QoL (PQ-10, 6.1 ± 2 vs 7.1 ± 1.3; p=0.007; EUROHIS-QOL8, 3.5 ± 0.5 vs 3.7 ± 0.4; p=0.034) were worse in patients with 5-2-1 positive criteria. Moreover, nonmotor symptoms burden (Non-Motor Symptoms Scale total score, 64.8 ± 44.8 vs 39.4 ± 35.1; p<0.0001) and autonomy for activities of daily living (ADLS scale, 73.5 ± 13.1 vs 89.2 ± 9.3; p<0.0001) were worse in patients with 5-2-1 positive criteria. Patient’s principal caregiver’s strain (Caregiver Stain Index, 4.3 ± 3 vs 1.5 ± 1.6; p<0.0001), burden (Zarit Caregiver Burden Inventory, 28.4 ± 12.5 vs 10.9 ± 9.8; p<0.0001), and mood (Beck Depression Inventory II, 12.2 ± 7.2 vs 6.2 ± 6.1; p<0.0001) were worse in patients with 5-2-1 positive criteria as well. Conclusions. QoL is worse in patients meeting ≥1 of the 5-2-1 criteria. This group of patients and their caregivers are more affected as a whole. These criteria could be useful for identifying patients in which it is necessary to optimize Parkinson’s treatment.
5
Kurokawa, Y., K. Yoshimura, S. Yamamoto, A. Sato, I. Saito, and H. Fukuda. "Inter-criteria reproducibility of RECIST, WHO, Japanese response criteria for gastric cancer or esophageal cancer: From the response dataset of Japan Clinical Oncology Group (JCOG) phase III trials." Journal of Clinical Oncology 24, no. 18_suppl (2006): 4065. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.4065.
Full textAbstract:
4065 Background: For assessments of tumor response in upper gastrointestinal cancers, Japanese criteria (JPN), which needs X-ray or endoscopic findings for primary lesion, has been generally used in Japan instead of international RECIST or WHO criteria. To compare the inter-criteria reproducibility of these radiological assessments, we analyzed the datasets of tumor responses from two phase III trials. Methods: A total of 115 gastric cancer patients in two treatment arms of JCOG9205, 5-FU and 5-FU plus cisplatin, and 103 esophageal cancer patients in a neoadjuvant 5-FU plus cisplatin arm of JCOG9907 were eligible for this analysis. Overall response rates (ORR) were calculated according to each of three criteria. The tumor responses, furthermore, were divided into four categories (CR, PR, SD, PD), following estimation of kappa statistics between two criteria as agreement measure. Results: As shown in the Table , ORR according to RECIST and WHO were very similar in both cancers. JPN tended to estimate higher ORR comparing to RECIST or WHO, particularly in esophageal cancer. In gastric cancer, kappa for concordance to RECIST were 0.92 for WHO and 0.86 for JPN. While in esophageal cancer, kappa were 0.72 for WHO and 0.40 for JPN. Conclusions: In these trials for gastric cancer and esophageal cancer, there was fairly consistent reproducibility between unidimensional RECIST and bidimensional WHO criteria. JPN criteria, depending on assessment of primary lesion, may give higher ORR particularly in esophageal cancer, and cautious interpretation may be necessary when evaluating ORR from Japanese trials using JPN criteria (Table). Overall response rates of respective treatment arms calculated according to RECIST, WHO and JPN criteria. [Table: see text] No significant financial relationships to disclose.
6
Thangjam, Rajendra Singh, Rothangpui ., Anil Irom, Rameshchandra Th, Sivasubramanian Ramakrishnan, and Anita Saxena. "Utility of world heart federation and modified World Health Organization echocardiographic diagnostic criteria of subclinical rheumatic heart disease in children of Manipur, India." International Journal of Advances in Medicine 6, no. 2 (2019): 412. http://dx.doi.org/10.18203/2349-3933.ijam20191151.
Full textAbstract:
Background: A comparative prevalence studies using modified WHO and more stringent criteria of WHF2012 have not been conducted in this part of the country and so authors felt necessary to conduct such study in this North-eastern state of India.Methods: In this cross-sectional study, 3600 children aged 5-15 years (11.07±2.86, 51.90% male) from randomly selected schools of Manipur were examined clinically and by 2D colour doppler echocardiography.Results: Only one case of Clinical RHD with a combination of MR and AS was found, (prevalence of 0.28/1000) [CI: 0.04-1.97). Echocardiography detected 3 cases of definite subclinical (prevalence rate of 0.83/1000 (CI: 0.27-2.58], 14 cases of borderline subclinical RHD (prevalence rate of 3.9)/1000 (CI: 2.30-6.56) befitting WHF 2012 criteria, and 61 cases of borderline subclinical RHD befitting modified WHO criteria (prevalence rate of 16.9/1000)[ CI1.3-2.1].On follow up to 5 years, among the 3 cases with definite subclinical RHD, 2 had worsened and 1 remained non- progressive, while among the 14 subclinical borderline cases, 2 normalized, 6 remained non-progressive and 6 children were lost to follow up.Conclusions: Prevalence of RHD using echocardiography is several folds higher compared to clinical examination alone. While the number is reduced by about half using WHF criteria. However, the important of WHO criteria cannot simply be neglected, as all the subclinical cases by WHF criteria remains non-progressive, while one case of subclinical defined by WHO worsen on follow up.
7
Lestari, Yunda. "EFL students’ speaking ability in descriptive text." Concept : Community Concern for English Pedagogy and Teaching 7, no. 1 (2021): 45–52. http://dx.doi.org/10.32534/jconcept.v7i1.1821.
Full textAbstract:
This study aimed to find out EFL students’ speaking ability in a descriptive text. This research was a descriptive survey. The participants were chosen by using cluster random sampling technique where there were twenty students at the eleventh-grade students of SMA Negeri 4 OKU. The data were collected through oral test in the form of online test and telephone survey. WhatsApp application was used as an online platform in data collection. The result of the study showed that the total of students’ score was 1142 and mean of the students’ score was 57,1. There were 1 student (5%) who gains score 80-100 in very good criteria, 2 students (10%) who gain score 66-79 in good criteria, 10 students (50%) who gain score 56-65 in enough criteria, 5 students (25%) who gain score 46-55 in low criteria, and 2 students (10%) got score 45 in fail criteria. Based on the data, there were only 13 students (65%) who passed the students’ speaking ability. In conclusion, the frequency of criteria of students’ speaking ability is in enough criteria.
 Key words: EFL; Speaking abilit; Descriptive text
8
Chaudhary, Gunjan, Chita Raghunandan, and Kanika Chopra. "Screening and diagnosis of gestational diabetes mellitus by IADPSG criteria." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 2 (2019): 543. http://dx.doi.org/10.18203/2320-1770.ijrcog20190281.
Full textAbstract:
Background: GDM is a complex clinical entity and its screening, diagnosis, and management warrants attention. With this issue in mind, we aimed to study the prevalence of gestational diabetes mellitus in the antenatal group of patients attending tertiary hospital in New Delhi and its association with maternal outcome.Methods: 300 pregnant patients were enrolled in the first trimester and RBS (random blood sugar) was done. Those who had RBS >200mg/dl were labelled as overt diabetes and excluded from the study. The patients who were screened negative in phase 1 of screening were subjected to the next phase of screening at 24-28 weeks of gestation with 2-hour 75g OGTT using IADPSG criteria. Those who were diagnosed as GDM were followed in the antepartum, intrapartum and postpartum period.Results: The prevalence of overt diabetes and GDM in the study population is 1.33% and 13.33%. The prevalence of gestational hypertension, pre-eclampsia, chronic hypertension, polyhydramnios was 15%, 5%, 5%, 7.5% respectively. Normal and instrumental vaginal delivery was in 50 %, 5% patients respectively and 45 % had the caesarean section.Conclusions: The single step OGTT with lower threshold value cut-offs and single abnormal value for the diagnosis of GDM as advocated by IADPSG seem to be effective as it helps to screen and diagnose GDM at the same time as a single step procedure and thus more cost-effective.
9
García-Carbonero, R., M. Hidalgo, L. Paz-Ares, et al. "Patient selection in high-dose chemotherapy trials: relevance in high-risk breast cancer." Journal of Clinical Oncology 15, no. 10 (1997): 3178–84. http://dx.doi.org/10.1200/jco.1997.15.10.3178.
Full textAbstract:
PURPOSE To evaluate the impact of the selection criteria that are used in current high-dose consolidation chemotherapy (HDCT) trials on the outcome of high-risk breast cancer patients treated with conventional adjuvant chemotherapy. PATIENTS AND METHODS From 1975 to 1995, 265 breast cancer patients at our institution showed involvement of ten or more positive axillary lymph nodes. Of these, 171 received standard adjuvant combination chemotherapy, but not HDCT consolidation, and were the subjects of our study. One hundred twenty-eight patients met the standard selection criteria for HDCT with hematological support (< 60 years, no significant concomitant disease, and no progression during adjuvant treatment), whereas 43 did not. Clinical outcome was analyzed by using disease-free survival (DFS) and overall survival (OS) as endpoints. To provide an assessment of the short-term efficacy of HDCT, we also evaluated the outcome in a cohort of 39 patients from the last 4 years who met the criteria for, and were actually treated with, HDCT after adjuvant chemotherapy. RESULTS With a median follow-up of 4.4 years (range, 0.7 to 17.2 years), 112 of the 171 patients have had a relapse, and 87 have died. The estimated 5-year DFS was 32.3%, and OS was 49.4%. DFS was significantly higher for patients who met the HDCT criteria (36.6% at 5 years) than for those who did not (15.8% at 5 years; P < .05). OS was also significantly more favorable in patients meeting HDCT criteria (55.4% at 5 years) than in patients not meeting HDCT criteria (22.7% at 5 years; P < .01). We performed a multivariate analysis to adjust for other potential prognostic factors and found that meeting the HDCT criteria and having undergone locoregional radiotherapy were the only significant independent predictors for DFS and OS. Finally, we compared the outcome of the 128 patients who met the HDCT criteria and were treated with conventional adjuvant chemotherapy only with that of the 39 patients who met the criteria and who actually underwent HDCT, and we did not observe significant differences in the DFS or OS between these groups. CONCLUSIONS Meeting HDCT inclusion criteria is an independent indicator of favorable prognosis in high-risk breast cancer patients. The selection of patients by these criteria may explain, at least in part, the promising short-term results of nonrandomized adjuvant HDCT trials in high-risk breast cancer.
10
Lee, Ik Jae. "Correlating radiologic response criteria with pathologic tumor viability in HCC patients undergoing localized radiation followed by surgical resection." Journal of Clinical Oncology 31, no. 4_suppl (2013): 217. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.217.
Full textAbstract:
217 Background: Various radiologic response criteria have been developed for solid tumors. This study attempts to identify the optimal criteria for hepatocellular carcinoma (HCC) after localized treatment including radiotherapy. Methods: We reviewed 40 consecutive HCC patients who underwent surgical resection after radiotherapy of curative intent between 2000 and 2011. Radiation was delivered concurrently with intraarterial 5-fluorouracil/cisplatin (36), concurrently with capecitabine (2), and after receiving transarterial chemoembolization (2). For radiotherapy, 45 Gy in 25 fractions (32) or 50 Gy in 20 fractions (8) was delivered. Images from pre-RT and pre-resection CT were compared to determine treatment response according to Response Evaluation Criteria in Solid Tumors (RECIST), the World Health Organization (WHO) criteria, modified RECIST (mRECIST), and European Association for the Study of the Liver (EASL) criteria. Findings from pathologic reports including extent of tumor necrosis were correlated with degree of response from each set of criteria. Results: Intermodal agreement among criteria was highest between RECIST and WHO (p<0.0001) and between mRECIST and EASL (p<0.0001). All criteria showed strong correlation with reduction in α-fetoprotein (p=0.001 for EASL and mRECIST, 0.026 for RECIST, and 0.043 for WHO). Percent of viable tumor by EASL was most strongly correlated with percent of pathologic viable tumor (p<0.0001), followed by RECIST, mRECIST, and WHO (p = 0.011, 0.013, and 0.013). Resection was carried out after 2 complete (5%), 36 partial (90%), and 2 stable (5%) responses according to EASL criteria. Three year disease-free (DFS) and overall survival (OS) were 29 and 61 months. Complete necrosis showed trends toward improved DFS (p=0.136) and OS (p=0.088). Multiplicity was independent prognostic factor for both DFS and OS (p=0.005 and 0.001). Conclusions: EASL criteria showed strongest correlation with pathologic tumor viability after localized treatment for HCC. Prospective clinical trial is warranted.
11
van Vliet, JA, PJE Eekers, J. Haan, and MD Ferrari. "Evaluating the IHS Criteria for Cluster Headache – a Comparison between Patients Meeting all Criteria and Patients Failing One Criterion." Cephalalgia 26, no. 3 (2006): 241–45. http://dx.doi.org/10.1111/j.1468-2982.2006.00932.x.
Full textAbstract:
Cluster headache (CH) is diagnosed according to criteria of the International Headache Society (IHS), but, in clinical practice, these criteria seem too restrictive. As part of a nation-wide study, we identified a group of patients who met all criteria minus one (IHS-CH-1), and assessed in which way they differed from CH patients meeting all criteria (IHS-CH). We performed a nation-wide questionnaire study for CH and CH-like syndromes, including questions based on the IHS criteria, and additional features such as restlessness during attacks, nocturnal onset of attacks, circadian rhythmicity of attacks and response to treatment. IHS-CH and IHS-CH-1 patients were compared. Of 1452 responders to two questionnaires, 1163 were IHS-CH and 289 were IHS-CH-1. The majority of the IHS-CH-1 patients were classified as such because their attacks exceeded 3 h (64%, median attack duration: 5 h), or came in a frequency of less than 1 per 2 days (16%). Age at onset was similar between the groups. The male to female ratio was 3.7 : 1 in the IHS-CH group and around 1.6 : 1 in the IHS-CH-1 groups ( P < 0.005). Patients with attacks exceeding 3 h less often reported a circadian rhythmicity (IHS-CH-1: 49%, IHS-CH: 64%), episodic periodicity (IHS-CH-1: 65%, IHS-CH: 78%), nocturnal attacks (IHS-CH-1: 67%, IHS-CH: 78%), smoking (IHS-CH-1: 90%, IHS-CH: 80%) and restlessness during attacks (IHS-CH-1: 64%, IHS-CH: 76%) than IHS-CH patients ( P < 0.005). Photo- or phono-phobia (IHS-CH-1: 67%, IHS-CH: 54%) and nausea (IHS-CH-1: 38%, IHS-CH: 27%) were more frequently reported by patients who reported to have attacks exceeding 3 h ( P < 0.005). Similar proportions reported effect of verapamil on their attacks (IHS-CH-1: 54%, IHS-CH 61%). We conclude that average attack duration exceeding 3 h was frequently the reason for not fulfilling IHS CH criteria. Symptoms often accompanying CH such as restlessness, nocturnal attacks and an episodic attack pattern were relatively frequently present in IHS-CH-1 patients with longer attacks. These patients may therefore be diagnosed with CH. Attack frequency may not be a useful criterion for the diagnosis of CH. The upper limit of 3 h should be increased in future diagnostic criteria.
12
Jashar, Dasal Tenzin, Laura A. Brennan, Marianne L. Barton, and Deborah Fein. "Cognitive and Adaptive Skills in Toddlers Who Meet Criteria for Autism in DSM-IV but not DSM-5." Journal of Autism and Developmental Disorders 46, no. 12 (2016): 3667–77. http://dx.doi.org/10.1007/s10803-016-2901-7.
Full text
13
Wawan, Wawan Taufiq, Supriyanto Supriyanto, and Sidik Rahmatullah. "Implementasi SPK Karyawan Terbaik Metode A-Hirarki Proses dan S-Additive Weighting." Jurnal SIMADA (Sistem Informasi dan Manajemen Basis Data) 6, no. 2 (2023): 124–33. http://dx.doi.org/10.30873/simada.v6i2.3701.
Full textAbstract:
PT. Puncak Menara Hijau Mas Kotabumi is an industrial company engaged in the wood processing business. This company processes wood into 4 kinds of materials which are ready to be supplied to Java Island and some are exported to Japan. The 4 types of processed wood produced are Sawntimber ex KD, S4S (4-sided shaved), Plywood and Furniture. In order to increase the quality of decisions, decision support systems combine various intelligence sources. We use 2 methods, namely AHP and SAW, weight Criteria1 16%, Criteria 2 33%, Criteria 3 13%, Criteria 4 11%, Criteria 5 6%,, Criteria 6 17%, Criteria 7 4% The final result of the employee who is given the best predicate is Alternative 47 with a rank of 2,049 . So that the employee is entitled to get a prize/bonus as the best employee
14
Smith, Miriam J., Naomi L. Bowers, Michael Bulman, et al. "Revisiting neurofibromatosis type 2 diagnostic criteria to exclude LZTR1-related schwannomatosis." Neurology 88, no. 1 (2016): 87–92. http://dx.doi.org/10.1212/wnl.0000000000003418.
Full textAbstract:
Objective:To determine the specificity of the current clinical diagnostic criteria for neurofibromatosis type 2 (NF2) relative to the requirement for unilateral vestibular schwannoma (VS) and at least 2 other NF2-related tumors.Methods:We interrogated our Manchester NF2 database, which contained 205 individuals meeting NF2 criteria who initially presented with a unilateral VS. Of these, 83 (40.7%) went on to develop a contralateral VS. We concentrated our genetic analysis on a group of 70 who initially fulfilled NF2 criteria with a unilateral vestibular schwannoma and at least 2 additional nonintradermal schwannomas.Results:Overall, 5/70 (7%) individuals with unilateral VS and at least 2 other schwannomas had a pathogenic or likely pathogenic LZTR1 mutation. Twenty of the 70 subsequently developed bilateral disease. Of the remaining 50, 5 (10%) had a germline LZTR1 mutation, equivalent to the number (n = 5) with a germline NF2 mutation.Conclusions:The most common etiology for unilateral VS and 2 additional NF2-associated tumors in this cohort was mosaic NF2. Germline LZTR1 and germline NF2 mutations were equally common in our cohort. This indicates that LZTR1 must be considered when making a diagnosis of NF2 in the presence of unilateral VS in individuals without a germline NF2 mutation.
15
Raharjo, Trubus, and Supra Wimbarti. "Assessment of learning difficulties in the category of children with dyslexia." Jurnal Konseling dan Pendidikan 8, no. 2 (2020): 79. http://dx.doi.org/10.29210/141600.
Full textAbstract:
This study is aimed to assess the diagnostic criteria for children with dyslexia. The diagnostic criteria are based on behavioral symptoms that appear in children with difficulty in reading and writing. The measurement of criteria of dyslexia is based on the criteria found in the specific learning difficulties category in DSM-5. Measurements were made of children who were considered to have learning difficulties as indicated by the inability and poor learning outcomes. Measurements were by testing the ability to read and write. Research used a qualitative approach with a case study method to obtain a description of the results. Research subjects were conducted on 65 elementary school students who had indications of learning difficulties. The results on the ability to read and write obtained as many as 28 students who were indicated to have criteria of dyslexia. Materials testing with aspects of phonological awareness and orthographic aspects. The next measurement is done by conducting an intelligence test using WISC III. Combining the results of measurements of reading and writing abilities and the results of intelligence tests are used to diagnose children with dyslexia, based on the criteria for indications of dyslexia taken from DSM-5. The results category on children with dyslexia can be diagnosed using one or more of the categories available on DSM-5
16
Baek, Hee Jo, Jun Hyung Lee, Hyun Gyung Lee, Ho Sung Kim, Myung Geun Shin, and Hoon Kook. "Genetic Mutations By Next-Generation Sequencing in Childhood Biphenotypic Acute Leukemia." Blood 132, Supplement 1 (2018): 5117. http://dx.doi.org/10.1182/blood-2018-99-118269.
Full textAbstract:
Abstract Introduction: Biphenotypic leukemia (BAL) or acute leukemias of ambiguous lineage (ALAL) is an uncommon manifestation of childhood acute leukemia. The aim of this study is to further assess clinicopathological characteristics and genetic mutation of de novo BAL or ALAL. Materials and Methods: Among 377 patients ≤ 18 years old who were diagnosed with de novo Acute leukemia from 2001 to 2017, 12 patients (3.2%) satisfied the definition of BAL by the European Group for the Immunological Classification of Leukaemias (EGIL) criteria or ALAL by World Health Organization (WHO) criteria. By the EGIL criteria, 11 patients were diagnosed as BAL: B-cell/myeloid (B/My) phenotype, 5; T-cell/myeloid (T/My) phenotype, 5. By the 2008 WHO criteria, 7 patients (1.9%) remained as ALAL: acute undifferentiated leukemia (AUL), 2; MPAL, 5. The remaining 5 BAL patients were redirected as ALL (n=3) and AML (n=2). Except one case with ALL by WHO criteria, 11 cases were examined by next generation sequencing using 60 gene panels. Results: In 5 patients with MPAL by the WHO criteria, a total of 31 distinct mutations were identified in 26 different genes. One case had BCR-ABL gene rearrangement. PTPN11 and NDS1 were recurrent mutation in 2 patients. In 2 patients with AUL, a total of 8 distinct mutations were identified in 8 different genes. In 2 cass of AML, 19 distinct mutations were identified in 15 differnet genes. FLT3-ITD was recurrent mutation. In 2 case of ALL, 17 distinct mutations were identified in 14 differrent genes. The median age of the patients at diagnosis was 8.6 years (range, 0 months-17.8 years). Six patients initially received AML-directed induction therapy, whereas 6 patients received ALL-directed induction therapy. Overall, 7 of the 12 (58.3%) patients achieved a complete remission (CR) after their initial induction therapy. ALL-directed induction chemotherapy was associated with higher chances of achieving a CR as compared to AML-directed regimens (100.0% vs. 16.7%; P =0.015). Nine patients except three cases (1, progression of disease; 1, intracranial hemorrhage during chemotherapy; 1, in continuous CR over 7 years chemotherpay only) underwent an allogeneic hematopoietic stem cell transplantation. With a median follow-up of 5 years, 5 year overall survival (OS) rate was 51.1±15.8% and event-free survival (EFS) rate was 51.9±15.7%. MPAL by WHO criteria seemed to have a better OS and EFS than AUL (both for 75.0 ± 21.7% vs. 0.0%; P=0.008). Conclusions: BAL or ALAL contains heterogeneous genetic mutation. ALL-directed induction chemotherapy was much better in achieving CR than AML-directed induction chemotherapy. And, patients with MPAL as defined by 2008 WHO definition have better clinical contcome compared with patients with AUL. Disclosures No relevant conflicts of interest to declare.
17
Preuss, U. W., S. Watzke, and F. M. Wurst. "Dimensionality and stages of severity of DSM-5 criteria in an international sample of alcohol-consuming individuals." Psychological Medicine 44, no. 15 (2014): 3303–14. http://dx.doi.org/10.1017/s0033291714000889.
Full textAbstract:
Introduction.The DSM-5 alcohol use disorder (AUD) criteria proposal contains 11 criteria that include most of the DSM-IV abuse and dependence criteria plus craving. The aims of the current study in a large and international alcohol-consuming sample were to confirm the dimensionality of the DSM-5 AUD criteria and to differentiate grades of severity of DSM-5 AUD in subjects who pass the proposed DSM-5 diagnostic threshold of two criteria.Method.We used the World Health Organization (WHO)/International Society on Biomedical Research on Alcoholism (ISBRA) Study on State and Trait Markers of Alcohol Use and Dependence dataset. Subjects included in the analyses were aged ⩾18 years and were recruited in five countries: Australia, Brazil, Canada, Finland and Japan. Assessment of AUD and additional characteristics was conducted using an adapted version of the Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS). Dimensionality of the DSM-5 criteria was evaluated using factor analysis and item response theory (IRT) models. The IRT results led to the classification of AUD patients into three severity groups. External validators were used to differentiate statistically across subgroups.Results.A total of 1424 currently drinking individuals were included in the analyses. Factor and IRT analyses confirmed the dimensional structure of DSM-5 AUD criteria. More than 99% of the subjects could be allocated to one of the suggested severity subgroups. The magnitude of the external validators differed significantly across the severity groups.Conclusions.The results confirm the dimensional structure of the proposed DSM-5 AUD criteria. The suggested stages of severity (mild, moderate and severe) may be useful to clinicians by grouping individuals not only in the mild but also in the moderate to severe spectrum of DSM-5 AUD.
18
Urowitz, Murray B., Dafna D. Gladman, Dominique Ibañez, et al. "American College of Rheumatology Criteria at Inception, and Accrual over 5 Years in the SLICC Inception Cohort." Journal of Rheumatology 41, no. 5 (2014): 875–80. http://dx.doi.org/10.3899/jrheum.130704.
Full textAbstract:
Objective.To determine the frequency of each American College of Rheumatology (ACR) criterion met at time of enrollment, and the increase in each of the criteria over 5 years.Methods.In 2000 the Systemic Lupus International Collaborating Clinics (SLICC) recruited an international inception cohort of patients with systemic lupus erythematosus (SLE; ≥ 4 ACR criteria) who were followed at yearly intervals according to a standard protocol. Descriptive statistics were used to assess the total and cumulative number of ACR criteria met at each visit. Regression models were done to compare the increase of individual and cumulative criteria as a function of race/ethnicity group, and sex.ResultsIn all, 768 patients have been followed for a minimum of 5 years. Overall, 59.1% of the patients had an increase in the number of ACR criteria they met over the 5-year period. The mean number of ACR criteria met at enrollment was 5.04 ± 1.13 and at year 5 was 6.03 ± 1.42. At enrollment, nonwhite patients had a higher number of ACR criteria (5.19 ± 1.23) than white patients. The total number of criteria increased in both white and nonwhite ethnicities, but increased more among whites. Males had a slightly lower number of criteria at enrollment compared to females and males accrued fewer criteria at 5 years.Conclusion.In this international inception cohort of SLE patients with at least 4 ACR criteria at entry, there was an accumulation of ACR criteria over the following 5 years. The distribution of criteria both at inception and over 5 years is affected by sex and ethnicity.
19
Park, Lisa R., Erika B. Gagnon, and Kevin D. Brown. "The Limitations of FDA Criteria: Inconsistencies with Clinical Practice, Findings, and Adult Criteria as a Barrier to Pediatric Implantation." Seminars in Hearing 42, no. 04 (2021): 373–80. http://dx.doi.org/10.1055/s-0041-1739370.
Full textAbstract:
AbstractChildren require greater access to sound than adults as they are learning to communicate using hearing and spoken language. Yet when it comes to cochlear implant candidacy, currently approved Food and Drug Administration (FDA) criteria for adults are much less restrictive than those for children, allowing for greater levels of residual hearing and aided speech recognition in adults. Cochlear implant guidelines for children have changed very little in the 30 years since cochlear implants have been approved for pediatrics, and this lack of change has proven to be a barrier to implantation. Using evidence-based practice, centers have been providing off-label implantation for children who fall outside of current FDA criteria, including children with more residual hearing, children with single-side deafness younger than 5 years, and infants with bilateral profound loss younger than 9 months. The purpose of this article is to outline how these restrictions impede access to implants for children and describe the evidence supporting cochlear implantation in children who fall outside of current criteria.
20
Lei, Lei, Han-Ching Chan, Wang Xiao Jia, Tzu-Pin Lu, and Skye Hung-Chun Cheng. "Recurrence risk stratification by Dutch clinical risk criteria for early-stage luminal breast cancer patients in Taiwan: A population-based analysis." Journal of Clinical Oncology 38, no. 15_suppl (2020): e12509-e12509. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e12509.
Full textAbstract:
e12509 Background: Dutch clinical risk criteria (low-risk definition: age > 35 years and (grade 1 with tumor ≤3cm, grade 2 with tumor ≤2cm, or grade 3 with tumor ≤1cm) have been used to stratify the benefit of MammaPrint and Oncotype DX for the decision-making regarding adjuvant chemotherapy for early-stage luminal breast cancer. We propose that the criteria could help to identify low-risk patients who could barely benefit from multi-gene testing. Methods: Breast cancer patients from Taiwan Cancer Database initially treated with primary surgeries between 2008 and 2012 who met the following criteria: (1) pathologic node-negative, (2) hormone receptor-positive, (3) HER2-negative, (4) undergone hormonal therapy, and (5) a minimum follow-up time of 5-year if free from any event, were enrolled in this study. Out of the total 2679 eligible patients, 1074 (40.1%) patients received adjuvant chemotherapy in addition to endocrine therapy. The study endpoints included breast cancer-specific survival (BCSS) and overall survival (OS). Kaplan-Meier statistics estimated the difference between clinical outcomes in low- and high-risk groups. Results: The median follow-up time of BSCC and OS was 5.9 years (range, 0-7 years) and 5.8 years (range, 0-7 years), respectively. There were statistical significances of 5-year BCSS (n = 2679) and 5-year OS (n = 2636) between low-risk and high-risk groups (in both endpoints, P < 0.0001). According to the Dutch criteria, low-risk patients with and without adjuvant chemotherapy had a 5-year BCSS of 99.0% vs. 99.2% and a 5-year OS of 98.4% vs. 97.4%, respectively. High-risk patients with and without adjuvant chemotherapy had a 5-year BCSS of 97.7% vs. 98.1% and a 5-year OS of 96.4% vs. 95.3%, respectively. Conclusions: The benefit of chemotherapy in low-risk patients classified by Dutch criteria might be very small since the breast cancer mortality was less than 1% with a minimum of 5-year follow-up. Dutch criteria cannot identify high-risk patients who would benefit from chemotherapy. We assumed that multi-gene testing in low-risk patients would not be cost-effective.
21
Shrestha, Biloni, and L. Pokhrel. "Comparative study of DIPSI and WHO 2018 criteria for diagnosis of GDM." Nepal Medical College Journal 22, no. 1-2 (2020): 13–17. http://dx.doi.org/10.3126/nmcj.v22i1-2.30023.
Full textAbstract:
Gestational Diabetes Mellitus (GDM) is an important public health problem. Prevalence has shown an increasing trend and varies based on diagnostic criteria used and the ethnic group studied. It is more common in Asia. Presently, there is no international consensus on the screening and diagnostic criteria for GDM. The Diabetes in Pregnancy Study Group of India (DIPSI) guidelines recommend the non-fasting 75g oral glucose tolerance test (OGTT) as a single-step screening and diagnostic test for GDM, is simple, easy and more feasible. The objective of this study was to compare whether the DIPSI criteria is equally sensitive to WHO 2018 criteria. This was a hospital based cross-sectional study done at Nepal Medical College Teaching Hospital, Kathmandu. Among 425 cases, 25 (5.88%) were diagnosed GDM, 6 (1.41%) were diagnosed only by DIPSI, 5 (1.18) only by WHO 2018 and 14 (3.29%) by both methods. The study showed that the sensitivity of DIPSI was 73.68% and specificity was 98.52%. The agreement between the DIPSI and WHO 2018 criteria ranged from 60% to 80% (Kappa value = 0.68). This study proves that DIPSI criteria is comparable to WHO 2018 criteria and can be adopted in our institution for the diagnosis of GDM as it is more feasible, easy and less expensive.
22
Collinson, P. O., A. C. Rao, R. Canepa-Anson, and S. Joseph. "Impact of European Society of Cardiology/American College of Cardiology guidelines on diagnostic classification of patients with suspected acute coronary syndromes." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 40, no. 2 (2003): 156–60. http://dx.doi.org/10.1258/000456303763046085.
Full textAbstract:
Background: Assessment of the relative diagnostic accuracy of investigation strategies for patients with suspected acute coronary syndromes (ACS). Methods: A prospective observational study followed two groups of patients over a 3-month period in a UK district general hospital. Group one: all admissions with suspected ACS ( n = 576); group two: non-cardiac in-patients who were suspected of developing ACS ( n = 87). Both were investigated by full clinical history, examination and serial electrocardiographs (ECGs). Conventional World Health Organization (WHO) criteria for myocardial damage were compared with diagnosis based on cardiac troponin T (cTnT). Clinical discharge diagnosis based on conventional WHO criteria was compared with the review diagnosis based on measurement of cTnT. Results: Diagnosis based on WHO criteria missed 58 patients (8·7%) admitted with suspected ACS who had high risk unstable angina. Thirty-three patients (5% of all admissions) who were diagnosed as non-Q wave acute myocardial infarction (AMI) were found to have normal troponin values and to have been incorrectly classified as AMI. Conclusions: Diagnostic strategies based on WHO criteria are inaccurate. The measurement of cTnT in all patients with suspected ACS would have increased the number of those with a diagnosis of AMI by 58 (8·7%), while avoiding inaccurate diagnosis in 33 (5%), therefore producing an absolute increase of 25/663 (3·8%) but a relative increase of 58/138 (42%). In patients with a primary diagnosis of suspected ACS, the overall increase in patients with a diagnosis of AMI will be 55 (9·5%), a relative increase of 55/118 (46·6%) but an absolute increase of 36/576 (6·3%).
23
Bendari, A., S. Sham, H. Hammoud, R. Al-Refai, A. Abdelhafez, and M. Harshan. "Application of WHO CNS Fifth Edition Criteria for Glioblastoma Multiforme Diagnosis: A single center study." American Journal of Clinical Pathology 160, Supplement_1 (2023): S91. http://dx.doi.org/10.1093/ajcp/aqad150.201.
Full textAbstract:
Abstract Introduction/Objective The fifth edition of the WHO classification of the tumors of the central nervous system (WHO CNS 5) published in 2021 introduced major changes that incorporate molecular diagnostics in CNS tumor classification along with histology and immunohistochemistry. Glioblastomas (GBM) were diagnosed based on the histologic features of diffuse and astrocytic glioma in adults, if there is microvascular proliferation and /or necrosis. Isocitrate dehydrogenase 1 (IDH) R132 H immunohistochemical stain expression and /or mutation analysis results were used to further classify GBMs as IDH mutant or IDH wild type. In WHO CNS 5 all IDH mutant diffuse astrocytic tumors are considered a single type (Astrocytoma, IDH mutant) and graded 2, 3, or 4. Glioblastoma IDH wild type is diagnosed in the setting of an IDH wild type diffuse and astrocytic glioma with microvascular proliferation or necrosis or TERT promoter mutation or EGFR gene amplification or +7/-10 chromosome copy number changes. In this study, we analyze how the change in diagnostic criterion would affect the classification of GBMs diagnosed in our institution retrospectively. Methods/Case Report The pathology database was searched for all diffuse gliomas diagnosed as GBM between 01/2019 and 12/2021. Age of the patient, gender, location of tumor, histologic features, IDH status and molecular alterations ( Onkosight Advanced solid tumor panel, 50 genes) were reviewed. Results (if a Case Study enter NA) A total of 74 adult high grade glial neoplasms were identified out of which 25 were GBMs. The age of the patients ranged from 40 to 87 years. 14 were men and 11 were females. All tumors had histologic features of GBM such as necrosis and microvascular proliferation. 24 (96%) tumors were IDH negative by immunohistochemistry and mutation analysis, and 1 (4%) was IDH strongly positive by immunohistochemistry. Molecular studies were not performed on this tumor. Conclusion 96% of GBMS diagnosed during the time period conformed to the WHO CNS 5 diagnostic criteria. The one IDH positive tumor would be reclassified as diffuse astrocytoma, IDH mutant, Grade 4. Like previous WHO classifications, WHO CNS 5 is a work in progress attempting to introduce new knowledge into the classification hoping to provide practical guidance to pathologists and neuro-oncologists and to benefit the patients with CNS tumors.
24
Nagle-Baranova, Baiba. "LEADERSHIP OF 5-6 YEAR OLD CHILDREN AND ITS ASSESSMENT CRITERIA." Education Reform: Education Content Research and Implementation Problems 1 (July 7, 2024): 35–44. http://dx.doi.org/10.17770/er2024.1.7931.
Full textAbstract:
The research aim is analyze theoretical literature to ascertain the relevance of leadership skills of 5-6-year-old children and leadership assessment criteria. When comparing and analyzing the information provided in various studies, the leadership abilities of adults and educators are more often emphasized. The content of competence education reveals how important it is to develop leadership skills in preschool children. During the research, it was concluded that the leadership skills of adults are equivalent to the typical skills of 5-6-year-old children, which develop at this age. Several of these skills are learned by integrating cross-cutting skills into the pedagogical process. As a result of the theoretical analysis, six leadership evaluation criteria and 4 levels of 5-6-year-old children were identified. Children who have developed their leadership skills are more successful in the next stages of education. According to the summary of the results, it can be concluded that every 5-6-year-old child possesses leadership skills to a greater or lesser extent, it is important to notice these skills in time and continue further development based on children's strengths.
25
Zachar, Peter, Michael B. First, and Kenneth S. Kendler. "The DSM-5 proposal for attenuated psychosis syndrome: a history." Psychological Medicine 50, no. 6 (2020): 920–26. http://dx.doi.org/10.1017/s0033291720000653.
Full textAbstract:
AbstractThis article narrates a consensus history of the proposal to include diagnostic criteria for a psychosis risk syndrome in the DSM-5, in part, to document what happened, but also to potentially help focus future efforts at clinically useful early detection. The purpose of diagnosing a risk state would be to slow and ideally prevent the development of the full disorder. Concerns about diagnosing a psychosis risk state included a high false positive rate, potentially harmful use of anti-psychotic medication with people who would not transition to psychosis, and stigmatization. Others argued that educating professionals about what ‘risk’ entails could reduce inappropriate treatments. During the revision, the proposal shifted from diagnosing risk to emphasizing current clinical need associated with attenuated psychotic symptoms. Within the community of researchers who studied psychosis risk, people disagreed about whether risk and/or attenuated symptoms should be an official DSM-5 diagnosis. Once it became clear that the DSM-5 field trials did not include enough cases to establish the reliability of the proposed criteria, everyone agreed that the criteria should be put in a section on conditions for further study rather the main section of the DSM-5. We close with recommendations about some practical benchmarks that should be met for including criteria for early detection in the classification system.
26
Syam, Dewi Rahmawati, Deny Salverra Yosy, Achirul Bakri, and Ria Nova. "Epidemiologic profiles of subclinical rheumatic heart disease in children." Paediatrica Indonesiana 60, no. 6 (2020): 334–40. http://dx.doi.org/10.14238/pi60.6.2020.334-40.
Full textAbstract:
Background Rheumatic heart disease (RHD) causes premature deaths every year worldwide. Low socioeconomic level is considered to be a risk factor facilitating the transmission of airway infections due to Streptococcus pyogenes. Subclinical RHD is a stage of RHD in which heart valve abnormalities have occurred according to the WHO or WHF classification but without any complaints to the subject. Echocardiography is used to screen subclinical RHD in several countries.
 Objective To estimate the prevalence, risk factors, and echocardiographic features of subclinical RHD in children.
 Methods This cross-sectional study was conducted on 250 elementary school children in Palembang, South Sumatera. We interviewed subject's parents about family characteristics, environment, and history of recurrent sore throat. Subjects underwent anthropometric examination, auscultation, and echocardiography. Diagnosis of RHD was based on World Health Organization (WHO) and World Heart Federation (WHF) criteria.
 Results Of 250 subjects, 132 (53.8%) were girls. Subjects’ age range was 5-14 years. The prevalence of subclinical RHD was 8% (95%CI 4.8 to 11.6). Of the 20 subclinical RHD subjects, 15 (75%) met the possible RHD criteria, 5 (25%) met the probable RHD criteria, and none met the definite RHD criteria. Multivariate analysis showed that household crowding (OR 8.135; 95%CI 1.048 TO 63.143; P=0.045), history of recurrent sore throat within the previous 6 months (OR 6,476; 95%CI 1.79 to 23.427; P=0.004) and age > 10 years (OR 3.167, 95%CI 1.184 to 8.471; P=0.022) significantly increased the risk of subclinical RHD.
 Conclusion The prevalence of subclinical RHD in elementary school children in Palembang was 8%. For echocardiographic features, most cases met the WHO/WHF possible RHD criteria. Factors significantly associated with the incidence of subclinical RHD are age > 10 years, household crowding, and history of recurrent sore throat in the previous 6 months.
27
Crisafulli, Francesca, Md Yuzaiful Md Yusof, Aamir Aslam, et al. "PERFORMANCE OF THE 2019 EULAR/ACR AND 2012 SLICC CLASSIFICATION CRITERIA FOR SLE AS DIAGNOSTIC CRITERIA." Journal of Rheumatology 52, Suppl 1 (2025): 228.2–229. https://doi.org/10.3899/jrheum.2025-0390.pv240.
Full textAbstract:
PV240 / #328Poster Topic:AS23 - SLE-Diagnosis, Manifestations, & OutcomesBackground/Purpose2019 EULAR/ACR SLE criteria were validated for classification from cases of established SLE compared to other diseases (sensitivity 0.96 (0.95 - 0.98); specificity 0.93 (0.91 - 0.95)),[1] but have not been assessed as diagnostic criteria in an undiagnosed cohort of ANA positive patients clinically suspected to have SLE. The aim is to evaluate, in these patients, the performance of 2019 EULAR/ACR SLE criteria against consultants’ diagnosis of SLE after 3 years follow-up and consultants’ treatment decision.MethodsWe included all consecutive consenting patients with ANA positive ≥ 1:80, new symptoms of ≤ 1 year, and SLE treatment naïve who had been referred to a specialist lupus clinic from primary care. 2019 EULAR/ACR SLE criteria and 2012 SLICC criteria were evaluated by research fellows at the time of the enrollment (T0) and evaluated annually, or on additional visits, during a 3-years follow-up. Clinical charts (at T0, and at the visit in which patients met classification criteria or last follow-up visit for those who did not meet them, T1) were anonymized and any documented diagnosis was redacted. Charts were reviewed by 4 consultants who had been independent of the patients’ clinical care to assess the diagnosis as well as confidence in diagnosis and suggested treatment decision. Interrater agreement was analyzed by Cohen’s k.Results141 patients were included. Table 1 reports baseline characteristics. At T1, SLE was diagnosed by consultants in 26 patients (18.4%); a moderate interrater agreement was observed (k=0.52; CI 0.31–0.72). The 2019 EULAR/ACR classification criteria were met in 36 patients (26%) and the 2012 SLICC criteria in 33 patients (23.4%). Other consultants’ diagnoses were: Undifferentiated CTD (UCTD, 19.1%), Sjögren’s Disease (SjD, 8%), inflammatory arthritis (IA, 3.5%). Table 2 reports sensitivity, specificity, PPV, NPV of the 2019 EULAR/ACR SLE and 2012 SLICC criteria. At T1, in 21 patients (14.8%) SLE diagnosis was agreed by the consultants and 2019 EULAR/ACR SLE criteria; consultants’ suggested treatments for these patients were: immunosuppressant (IS) +/- hydroxychloroquine (HCQ) in 11 cases (52.4%), HCQ alone in 9 (42.8%), and no treatment in 1 (4.8%). In 5 patients (3.5%) SLE was diagnosed by consultants but not classified by the EULAR/ACR SLE criteria; the suggested treatment from the consultants were: IS in 3 cases (60%), HCQ in 2 (40%). In 15 patients where 2019 EULAR/ACR criteria were met, consultants did not diagnose SLE (10.6%); consultants’ diagnoses were: SjD (40%), UCTD (33.3%), IA (26.7%%); treatment were: 7 HCQ (46.7%; in 1 case with im steroid), 5 IS (33.3%), 1 im steroid (6.7%) and no treatment in 2 (13%). In addition to the analyses above, at T0, the consultants diagnosed 11 patients who did not meet EULAR/ACR criteria as SLE. But at T1, 6/11 (55%) of these were subsequently classified as SLE. Thus, SLE could be diagnosed earlier than using classification criteria in some patients.Table 1:Features at baselineTable 2:Sensitivity, Specificity, Positive Predictive Value, Negative Predictive ValueConclusionsWhen used in a diagnostic setting, the performance of 2019 EULAR/ACR SLE criteria was less good than for classification. Patients meeting classification criteria were usually clinically diagnosed as SLE as well, but some patients with a consultant diagnosis of SLE did not meet criteria and in these cases, treatment decisions were similar to those meeting criteria. Classification criteria should be used with caution for the diagnosis when evaluating patients with suspected SLE. Future work will analyze a second cohort.References:[1.] Aringer M. ARD 2019;78(9):1151-9.
28
Mohammed, N. D., R. Raghavendra, B. Arjun, C. Aishwarya, and B. S. Sujatha. "Effectiveness of therapeutic plasma exchange in comparison with standard of care in the treatment of yellow phosphorus poisoning: an observational study in south Indian population." NEW ARMENIAN MEDICAL JOURNAL, no. 1 Vol19 (2025) (2025): 61–67. https://doi.org/10.56936/18290825-1.v19.2025-61.
Full textAbstract:
Yellow phosphorus poisoning is commonly seen in India, predominantly due to intentional self-harm. It is known to cause acute liver failure, which is a major contributory factor for its high mortality. Liver transplantation has been the definitive treatment in patients fulfilling the King’s College Hospital Criteria for liver transplantation. Therapeutic plasma exchange is an alternative treatment option that has shown promising results with significantly improved outcomes, in various studies. We conducted a single centre, prospective observational study in a tertiary care hospital in Southern India from August 2022 to March 2024. 46 patients were included in the study, 23 of whom underwent therapeutic plasma exchange. Patients were monitored throughout their hospital admission and were further grouped into those that fulfilled the King’s College Hospital criteria and those that did not. Fulfilment of King’s College Hospital criteria was found to be a poor prognostic indicator, with a mortality rate of 84% (p<0.001). Survival rate of 65% was seen in patients who underwent therapeutic plasma exchange (n=15), when compared to 57% (n=13) in those that did not (p=0.546). Among patients who met King’s College Hospital criteria, a mortality rate of 100% was seen without therapeutic plasma exchange (n=8), which was reduced to 72% (n=5) with the usage of therapeutic plasma exchange (p=0.228). Survival, among patients who underwent therapeutic plasma exchange, was directly proportional to number of cycles of therapeutic plasma exchange that they underwent (p=0.007). Early initiation of therapeutic plasma exchange (within 5 days of yellow phosphorus poisoning) had a survival rate of 73% (n=8), when compared to 58% (n=7) in those whom therapeutic plasma exchange was initiated after 5 days (p=0.46). Improved survival rates were seen in yellow phosphorus poisoning patients that underwent therapeutic plasma exchange, especially in those that met the King’s College Hospital criteria. However, statistical significance could not be established. Larger multicentric randomized controlled trials are needed to further analyse outcomes with the usage of therapeutic plasma exchange.
29
Jhajj, Bhvaneet, Ryan Henrie, Youness El-Khalidy, and Habib Moshref Razavi. "A Case of Acute Myeloid Leukemia Mimicking Blastic Plasmacytoid Dendritic Cell Neoplasm: Utility of the Proposed Upcoming WHO-5 Diagnostic Criteria." Case Reports in Hematology 2023 (November 1, 2023): 1–4. http://dx.doi.org/10.1155/2023/5014728.
Full textAbstract:
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy which is associated with a distinctive morphologic appearance. However, the morphology is not specific, and diagnostic characterization requires integration of immunophenotypic and genetic testing. We herein report a case of a 35-year-old female patient who presented with worsening cytopenia. A bone marrow aspirate identified medium-sized blastic cells with perinuclear microvacuoles (“pearl neckless”). Occasional blasts demonstrated a “hand mirror” appearance. Tandem flow cytometry showed an atypical population of dim CD45 events with expression of CD4, CD56, CD117, CD123, and monocytic markers such as CD64. Fluorescence in situ hybridization (FISH) showed evidence of a KMT2A rearrangement with an unknown partner on chromosome 19. Expression of MPO and muramidase was present. The final diagnosis was acute monocytic leukemia (AMoL). Due to the overlapping features of acute myeloid leukemia and BPDCN, the 5th Edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours provides new criteria for the diagnosis of BPDCN. Our case highlights the utility of these criteria.
30
Sekeres, Mikkael A., Jaroslaw P. Maciejewski, Harry Paul Erba, et al. "A Phase II Trial of Combination Therapy with Arsenic Trioxide (ATO) and Gemtuzumab Ozogamicin (GO) in Patients with High-Risk Myelodysplastic Syndromes (MDS) or Acute Myeloid Leukemia (AML) Arising from MDS." Blood 108, no. 11 (2006): 2669. http://dx.doi.org/10.1182/blood.v108.11.2669.2669.
Full textAbstract:
Abstract Background: Bone marrow findings in high-risk MDS are similar to those found in AML. MDS-associated myeloblasts are just as likely to express CD33 as AML myeloblasts, and cytogenetic abnormalities are similar to those of older AML patients (pts). Therapies effective in AML may also have activity in advanced MDS. GO is an anti-CD33 monoclonal antibody covalently linked to calicheamicin, a cytotoxic agent. ATO works through apoptotic and pro-differentiating mechanisms, and may allow for enhanced GO cytotoxicity. Methods: We conducted a multicenter trial in pts with high-risk MDS (IPSS score >1.5, or FAB or WHO classification with >5% CD33+ myeloblasts) or AML arising from MDS (with CD33+ myeloblasts) who had not received previous induction therapy, from 2/04 – 6/06. Pts received ATO (0.25mg/kg IV d1–5 during week 1, then twice weekly weeks 2–12) and GO (3mg/m2 on day 8) for 1 or 2 12-week cycles. Pts who had stable disease or improvement on a week 12 bone marrow biopsy received a second 12-week cycle, and then another week 24 biopsy. The primary endpoint was response as defined by the Modified International Working Group (IWG) criteria for MDS or, for AML patients, the IWG response criteria for AML. Results: Twenty-two pts have been enrolled; 21 are evaluable for response. The median age was 69 years. Fourteen pts (64%) had MDS (4 RAEB-1, 8 RAEB-2, 2 CMML-2,) with IPSS cytogenetic risk groups of good (2), intermediate (6), poor (4) and no growth (2), and IPSS classifications of high (5), Int-2 (5), and Int-1 (2). Eight pts (36%) had AML with cytogenetic risk groups as defined by CALGB 8461: intermediate (4), adverse (3), and unknown (1). Fifteen pts received prior therapies, including growth factors (10), 5-azacytidine (5), hydroxyurea (3), prednisone (1), anagrelide (1), thalidomide (1), and lenalidomide (1). Pts had a median of 15% blasts: 11.5% for MDS pts; 43.5% for AML pts. Of the 21 pts, 11 (52%) completed 1 cycle of therapy; an additional 5 (24%) completed 2 cycles. Reasons for discontinuing therapy included: withdrawing consent (5), progressive disease (7), and toxicity (4). Responses occurred in 8 patients (38%): 8 (38%) by the IWG MDS criteria; 2 of 8 AML pts (25%) by the IWG AML criteria; and 2 (9%) by both criteria. Using the modified IWG MDS criteria, 2 patients had a partial remission, 3 had a neutrophil response, 2 had a platelet response, and 1 had both platelet and neutrophil response. Using the IWG AML Criteria, 2 AML pts achieved a partial remission. Grade3/4 non-hematologic toxicities included neutropenic fever or infection (6), fatigue (4), pulmonary complications (3), hepatotoxicity (1), renal failure (1), prolonged QTc (1), nausea (1), epistaxis (1), hypoxia (1). Of 20 pts evaluable for 6 month survival, 15 (75%) were alive, 7 (47%) of whom responded to treatment. Of 12 patients evaluable for 1-year survival, 4 (33%) were alive, 2 of whom responded to treatment. Pts who completed two cycles of therapy spent a median of 13 days in the hospital. Conclusion: The combination of ATO + GO is well-tolerated and yields hematologic responses, particularly in neutrophils and platelets. This combination may be a viable alternative to high-dose, inpatient therapy in pts with high-risk MDS or secondary AML.
31
Voskanyan, S. E., V. S. Rudakov, A. I. Sushkov, et al. "Comparative analysis and validation of models and criteria for predicting hepatocellular carcinoma recurrence after liver transplantation." Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery 29, no. 4 (2024): 66–80. https://doi.org/10.16931/1995-5464.2024-4-66-80.
Full textAbstract:
Aim. To evaluate the accuracy and feasibility of using the most common criteria and models for predicting the survival and risk of hepatocellular carcinoma recurrence in clinical practice based on own experience in liver transplantation.Materials and methods. The single-center retrospective study included data on 70 patients who underwent transplantation from May 2010 to December 2022. Compliance with the criteria (Milan, UCSF, 5-5-500, etc.) was determined and the values of predictive models (Metroticket 2.0, Pre-ALRAL, etc.) were calculated for each observation. Survival rates, as well as efficiency of criteria and models were analyzed using sensitivity, specificity, F1 score, and C-index.Results. At the time of transplantation, the interquartile range for the number of tumors comprised 1–3, tumor sizes ranged from 1.8 to 5 cm, total tumor size ranged from 2.4 to 8.5 cm, and alpha-fetoprotein levels accounted for 14.7–150 ng/mL. During the follow-up period, hepatocellular carcinoma recurrence was recorded in 26% of patients. Disease-free and overall survival at 1, 3, and 5 years amounted to 89%, 76%, 63%, and 89%, 74.3%, 68%, respectively. The F1 score and C-index for predicting hepatocellular carcinoma recurrence after liver transplantation varied from 0.65 to 0.83, with the 5-5-500 criterion demonstrating the best performance. This criterion provided a five-year disease-free survival rate of 86% and an overall survival rate of 79%, with non-compliance leading to a decrease in survival to 33% and 46%.Conclusion. The studied criteria and models can be used to assess the risk of hepatocellular carcinoma recurrence after liver transplantation, although their predictive accuracy remains imperfect. An online calculator has been created to assess patient compliance with criteria and to predict disease-free and overall survival (https://nadit.ru/criterii). The development of own model and criteria within the framework of a Russian multicenter study, as well as the search for new objective methods for assessing the risk of hepatocellular carcinoma recurrence after liver transplantation, remain promising research areas.
32
Allgaier, A. K., I. Liwowsky, D. Kramer, R. Mergl, S. Fejtkova, and U. Hegerl. "Screening for depression in nursing homes: Validity of the WHO (Five) Well-Being Index." European Psychiatry 26, S2 (2011): 825. http://dx.doi.org/10.1016/s0924-9338(11)72530-5.
Full textAbstract:
IntroductionDepression is common in nursing home residents, but is still underrecognized. Screening for depression could be a first step to increase recognition rates within this high-risk group.ObjectivesTherefore, we investigated the validity of the WHO (Five) Well-Being Index (WHO-5) for early detection of depression in nursing home residents.MethodsThe Structural Clinical Interview for DSM-IV (SCID) was used as the gold standard for the validation of the WHO-5. The diagnoses covered in this assessment were both current major depression (MD) as well as minor depression (MinD) according to DSM-IV research criteria.ResultsIn our sample of 92 nursing home residents in Munich aged 65–97 years, (73.9% female, 26.1% male) 14.1% fulfilled the criteria of MinD, and again 14.1% fulfilled the criteria of MD in the SCID. Overall diagnostic validity (area under the ROC curve) of the WHO-5 was 90.1% (95% confidence interval: 83.5%–96.7%). The World Health Organization's recommended cut-off-point of 13 yielded a sensitivity of 92.3% for the category of ‘MinD or MD’, and a specificity of 74.2%. Corresponding values for an adapted cut-off point of 12 are 92.3% and 78.7%, respectively.ConclusionsThe diagnostic accuracy of the WHO-5 in our study is promising. The WHO-5 might be an efficient screening tool for nursing home residents, especially with the adapted cut-off point, but results have to be replicated in a larger sample.
33
Hagman, Brett T., Amy M. Cohn, Lawrence Schonfeld, Kathleen Moore, and Blake Barrett. "College students who endorse a sub-threshold number of DSM-5 alcohol use disorder criteria: Alcohol, tobacco, and illicit drug use in DSM-5 diagnostic orphans." American Journal on Addictions 23, no. 4 (2014): 378–85. http://dx.doi.org/10.1111/j.1521-0391.2014.12120.x.
Full text
34
Lusi Nur Ardhiani, Restu Tri Handoyo, and Sofia Retnowati. "FACTORS RELATED TO NON-SUICIDAL SELF-INJURY IN UNIVERSITY STUDENTS: A SCOPING REVIEW." Southeast Asia Psychology Journal (SAPJ) 13, no. 1 (2025): 58–77. https://doi.org/10.51200/sapj.v13i1.6342.
Full textAbstract:
Self-harm behaviors are associated with many unhealthy behavioral urges and future suicidal ideation or attempts. This behavior has also become a clinical condition that may need to be the focus of clinical attention in the most recent revised text of the Diagnostic and Statistical Manual of Mental Disorder. Self-injurious behaviors of varying severity were found among university students. This study aimed to identify predictors that influence the occurrence of NSSI, thereby increasing the chances of building an understanding of the etiology of self-harm behaviors in university students. To be included, all papers have to be peer-reviewed, written in English or Indonesian, and have a specific focus on university student populations. Papers specifically examined NSSI according to DSM-5 diagnosis criteria and were published after DSM-5 was published. Two articles were identified after conducting searches in three academic databases (Scopus, ProQuest, ScienceDirect) as well as Google Scholar. This review identified that university students who met the NSSI criteria were more likely to experience other mental disorders, severe role impairment, and a higher propensity to think about or attempt suicide compared to students who did not meet the criteria. Non-suicidal self-injury disorder can also be found independently and separately from other disorders, and thus, NSSI requires a different understanding and paradigm in handling. Some of the NSSI diagnostic criteria are field-proven and support the validation of the existence of the criteria proposed in the DSM-5. Future research utilizing the full DSM-5 criteria should be increased to add the necessary literature support in this regard.
35
ROY-BYRNE, P., W. R. SMITH, J. GOLDBERG, N. AFARI, and D. BUCHWALD. "Post-traumatic stress disorder among patients with chronic pain and chronic fatigue." Psychological Medicine 34, no. 2 (2004): 363–68. http://dx.doi.org/10.1017/s0033291703008894.
Full textAbstract:
Background. Fibromyalgia (FM), a chronic pain condition of unknown aetiology often develops following a traumatic event. FM has been associated with post-traumatic stress disorder (PTSD) and major depression disorder (MDD).Method. Patients seen in a referral clinic (N=571) were evaluated for FM and chronic fatigue syndrome (CFS) criteria. Patients completed questionnaires, and underwent a physical examination and a structured psychiatric evaluation. Critical components of the diagnostic criteria of FM (tender points and diffuse pain) and CFS (persistent debilitating fatigue and four of eight associated symptoms) were examined for their relationship with PTSD.Results. The prevalence of lifetime PTSD was 20% and lifetime MDD was 42%. Patients who had both tender points and diffuse pain had a higher prevalence of PTSD (OR=3·4, 95% CI 2·0–5·8) compared with those who had neither of these FM criteria. Stratification by MDD and adjustment for sociodemographic factors and chronic fatigue revealed that the association of PTSD with FM criteria was confined to those with MDD. Patients with MDD who met both components of the FM criteria had a three-fold increase in the prevalence of PTSD (95% CI 1·5–7·1); conversely, FM patients without MDD showed no increase in PTSD (OR=1·3, 95% CI 0·5–3·2). The components of the CFS criteria were not significantly associated with PTSD.Conclusion. Optimal clinical care for patients with FM should include an assessment of trauma in general, and PTSD in particular. This study highlights the importance of considering co-morbid MDD as an effect modifier in analyses that explore PTSD in patients with FM.
36
Putri, Meyrna Heryaning, Pudji Rahaju, and Dyah Indrasworo. "Hubungan ototoksisitas dan kemoterapi neoadjuvan pada karsinoma nasofaring berdasarkan ASHA, CTCAE, dan DPOAE." Oto Rhino Laryngologica Indonesiana 47, no. 2 (2018): 102. http://dx.doi.org/10.32637/orli.v47i2.219.
Full textAbstract:
Latar belakang: Kemoterapi neoadjuvan adalah induksi kemoterapi sebelum radioterapi dengan regimen cisplatin dan 5-Fluorouracil. Kemoterapi cisplatin bersifat ototoksik pada pendengaran sensorineural bilateral progresif dan bersifat irreversible. Kriteria dari American Speech-Language Hearing Association (ASHA) dan Common Terminology Criteria for Adverse Events (CTCAE) merupakan kriteria untuk mengidentifikasi ototoksisitas dengan menggunakan audiometri, selain pemeriksaan Distortion Product Otoacoustic Emissions (DPOAE). Tujuan: Mengidentifikasi hubungan ototoksisitas dengan kemoterapi neoadjuvan pada penderita karsinoma nasofaring (KNF) WHO tipe III menggunakan ASHA, CTCAE, serta DPOAE. Metode: Studi ini adalah penelitian observasional dengan desain cohort. Kriteria inklusi penelitian yaitu penderita baru KNF WHO tipe III, yang mendapatkan kemoterapi regimen standar dan berusia <60 tahun. Kriteria pemeriksaan DPOAE adalah penderita dengan ambang dengar ≤40 dB. Percontoh dilakukan pemeriksaan timpanometri, audiometri, dan DPOAE. Hasil: Terdapat 9 sampel percontoh penelitian. Uji repeated-ANOVA menunjukkan tidak ditemukan perbedaan bermakna pada tiga hasil pengukuran audiometri antara pascakemoterapi pertama, kedua, dan ketiga (p>0,05). Deteksi awal ototoksisitas menggunakan kriteria ASHA menunjukkan sensitivitas sebesar 67% dan dan CTCAE 44%, dibandingkan baku emas menggunakan DPOAE. Kesimpulan: Ototoksisitas cisplatin ditemukan sejak kemoterapi pertama dengan menggunakan pemeriksaan DPOAE walaupun tidak bermakna secara statistik. Kemampuan DPOAE untuk mendeteksi awal ototoksisitas lebih baik dibandingkan kriteria ASHA dan CTCAE yang menggunakan audiometri nada murni.Kata kunci: Karsinoma nasofaring, ototoksisitas sisplatin, DPOAE, CTCAE, ASHA ABSTRACT Introduction: Neoadjuvant chemotherapy is induction chemotherapy before radiotherapy with cisplatin and 5-Fluorouracyl regiment. Chemotherapy cisplatin is ototoxic, leads to frequently progresive and irreversible bilateral sensorineural hearing loss. American Speech-Language Hearing Association (ASHA) and Common Terminology Criteria for Adverse Events (CTCAE) are the criteria to determine ototoxicity with audiometry, beside Distortion Product Otoacoustic Emissions (DPOAE). Purpose: To identify the relationship between ototoxicity with neoadjuvant chemotherapy in patients NPC WHO type III using ASHA, CTCAE, and DPOAE. Method: This observational study approach with cohort design. Inclusion criteria: new patients NPC WHO type III who consented to undergo standard regiment chemotherapy, and age <60 year-old. For DPOAE examination: hearing level ≤40 dB. Exclucion criteria: NPC WHO type III patients who underwent chemotherapy with unconventional standard regiment. Examinations for hearing function conducted with tympanometry, pure tone audiometry, and Distortion Product Otoacoustic Emissions (DPOAE). Result: There were 9 sample in this study. The result of Repeated-ANOVA test showed no significant difference in three audiometry measurements among three series of chemotherapies. Early detection of ototoxicity using ASHA and CTCAE criterias showed sensitivity of 67% and 44% (compared with DPOAE as a gold standard). Conclusion: Cisplatin ototoxicity had occured since the first chemotherapy and detected with DPOAE, but statistically was not significantly related. Early detection of cisplatin ototoxicity with DPOAE was much better than with criteria American Speech-Language Hearing Association (ASHA) and Common Terminology Criteria for Adverse Events (CTCAE), which used pure tone audiometry.Keywords: Nasopharyngeal carcinoma, cisplatin ototoxicity, DPOAE, CTCAE, ASHA
37
Matsushita, Akihito, Minoru Tabata, Takashi Hattori, Wahei Mihara, and Yasunori Sato. "Surgical treatment in the chronic phase for uncomplicated Stanford type B aortic dissection." PLOS ONE 19, no. 2 (2024): e0298644. http://dx.doi.org/10.1371/journal.pone.0298644.
Full textAbstract:
Background The most appropriate surgical method for patients with uncomplicated type B aortic dissection (UTBAD) in the chronic phase remains controversial. This study evaluated the outcomes of patients with UTBAD who needed aortic treatment as well as the impact of the treatment method or indication criteria on their prognosis. Methods This retrospective review of 106 consecutive patients with aortic events in the chronic phase who underwent initial treatment for UTBAD between 2004 and 2021 comprised three groups: 19 patients who underwent endovascular repair (TEVAR), 38 who underwent open aortic repair and the medication group that included 49 patients. Aortic events were defined as a late operation or indication for operation for dissected aorta, aortic diameter (AD) ≥ 55 mm, rapid aortic enlargement (≥5 mm/6 months), and saccular aneurysmal change. The endpoint was all-cause death. We assessed the association between treatment methods or surgical indication criteria and mortality using a Cox regression analysis. Results The 5-year actuarial mortality rates were 27.1% in the TEVAR group, 19.6% in the open aortic repair group, and 38.4% in the medication group (p = 0.86). Moreover, the 5-year actuarial mortality rates in patients who had AD ≥ 55 mm were significantly higher than those patients with other surgical indication criteria (41.2% vs. 18.7%, p < 0.01). Multivariable analysis revealed a significant difference in AD ≥ 55 mm (hazard ratio [HR]: 2.88, 95% confidence interval [CI] 1.38–6.02, p < 0.01) and age (HR: 1.09, 95% CI 1.05–1.13, p < 0.01). Conclusions Under the existing surgical indication criteria, there was no difference in mortality rates among patients with UTBAD based on their surgical treatment.
38
Choi, Sang, Seong-Ryul Kwon, Ju-Yang Jung, et al. "Prevalence and Fracture Risk of Osteoporosis in Patients with Rheumatoid Arthritis: A Multicenter Comparative Study of the FRAX and WHO Criteria." Journal of Clinical Medicine 7, no. 12 (2018): 507. http://dx.doi.org/10.3390/jcm7120507.
Full textAbstract:
(1) Background: We evaluated the prevalence and fracture risk of osteoporosis in patients with rheumatoid arthritis (RA), and compared the fracture risk assessment tool (FRAX) criteria and bone mineral density (BMD) criteria established by the World Health Organization (WHO). (2) Methods: This retrospective cross-sectional study, which included 479 RA patients in 5 hospitals, was conducted between January 2012 and December 2016. The FRAX criteria for high-risk osteoporotic fractures were calculated including and excluding the BMD values, respectively. The definition of high risk for fracture by FRAX criteria and BMD criteria by WHO was 10-year probability of ≥ 20% for major osteoporotic fracture or ≥ 3% for hip fracture, and T score ≤ −2.5 or Z score ≤ −2.0, respectively. (3) Results: The mean age was 61.7 ± 11.9 years. The study included 426 female patients (88.9%), 353 (82.9%) of whom were postmenopausal. Osteoporotic fractures were detected in 81 (16.9%) patients. The numbers of candidates for pharmacological intervention using the FRAX criteria with and without BMD and the WHO criteria were 226 (47.2%), 292 (61%), and 160 (33.4%), respectively. Only 69.2%–77% of the patients in the high-risk group using the FRAX criteria were receiving osteoporosis treatments. The following were significant using the WHO criteria: female (OR 3.55, 95% CI 1.46–8.63), age (OR 1.1, 95% CI 1.08–1.13), and BMI (OR 0.8, 95% CI 0.75–0.87). Glucocorticoid dose (OR 1.09, 95% CI 1.01–1.17), age (OR 1.09, 95% CI 1.06–1.12), and disease duration (OR 1.01, 95% CI 1–1.01) were independent risk factors for fracture. (4) Conclusions: The proportion of RA patients with a high risk of osteoporotic fractures was 33.4%–61%. Only 69.2%–77% of candidate patients were receiving osteoporotic treatments while applying FRAX criteria. Independent risk factors for osteoporotic fractures in RA patients were age, the dose of glucocorticoid, and disease duration.
39
Wolfe, Frederick, Niklaus Egloff, and Winfried Häuser. "Widespread Pain and Low Widespread Pain Index Scores among Fibromyalgia-positive Cases Assessed with the 2010/2011 Fibromyalgia Criteria." Journal of Rheumatology 43, no. 9 (2016): 1743–48. http://dx.doi.org/10.3899/jrheum.160153.
Full textAbstract:
Objective.Widespread pain is no longer required for fibromyalgia (FM) diagnosis according to the American College of Rheumatology (ACR) 2010 preliminary diagnostic criteria and its 2011 modification, but its absence may be of concern. We investigated whether the widespread pain definition was satisfactory and the consequences of having a small number of painful regions or of not satisfying the widespread pain criterion.Methods.We studied 5011 patients who satisfied the 2011 criteria. FM was identified using the Widespread Pain Index (WPI) and the Symptom Severity Scale (SSS): WPI ≥ 7 and SSS ≥ 5 or WPI 3–6 and SSS ≥ 9. Widespread pain was 4 quadrants plus axial pain, according to the 1990 ACR FM criteria.Results.There were 4700 patients (93.8%) who satisfied the ACR 1990 widespread pain criterion. Using a new strict definition for 5 pain regions based on the WPI sites, a modified widespread pain criterion requiring 4 of 5 regions identified 98.8% of criteria-positive patients. Patients without widespread pain or those in the low WPI/high SSS group had milder FM and no evidence of increased psychological or physical distress.Conclusion.In usual clinical and epidemiological studies, the 2011 and 2010 criteria work well, but are not as effective in patients with asymmetrical or regional pain who do not satisfy a widespread pain criterion. A ≥ 4-pain region widespread pain definition will eliminate regional pain false-positives and will identify 98.8% of current 2011 cases. Future revisions of the 2010/2011 criteria should consider incorporating the ≥ 4-region requirement to avoid misclassification.
40
Li, Taiyu. "The difference Diagnosis criteria for PTSD." Journal of Education, Humanities and Social Sciences 26 (March 2, 2024): 1065–69. http://dx.doi.org/10.54097/njzg9155.
Full textAbstract:
Post-Traumatic Stress Disorder (PTSD) is a debilitating mental health condition that significantly affects individuals who have experienced trauma. PTSD has substantial impact on mental, emotional, and physical well-being, encompassing emotional distress, impaired social functioning, cognitive deficits, adverse physical health outcomes, and even suicidal ideation. Early diagnosis of PTSD is vital, given its profound consequences. The diagnostic process is intricate and involves diverse criteria and assessment tools. This research explores these diagnostic methods, focusing on the criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Classification of Diseases (ICD). Furthermore, it emphasizes the importance of self-rating scales and a groundbreaking discovery related to saliva as a potential diagnostic marker for PTSD. The evolution of diagnostic criteria, diagnostic frameworks in the DSM-5 and ICD-11, self-rating scales like the PTSD Checklist (PCL), and the potential of saliva as a diagnostic criterion are discussed. These diagnostic tools offer valuable insights for the assessment and diagnosis of PTSD, enhancing treatment and support for affected individuals.
41
Wattimury, Ince, Ine Arini, and Alwi Smith. "IMPROVING BIOLOGICAL SCIENCE LEARNING OUTCOMES WITH USED A CONTEXTUAL-BASED INQUIRY APPROACH THE CONCEPT OF PHOTOSYNTHESIS IN CLASS VIII STUDENTS OF JUNIOR HIGH SCHOOL NEGERI 2 AMBON." RUMPHIUS Pattimura Biological Journal 5, no. 2 (2023): 057–65. http://dx.doi.org/10.30598/rumphiusv5i2p057-065.
Full textAbstract:
The inquiry approach is one of the approaches proposed by experts to be developed in the learning process. Where inquiry learning teaches students how to research problems or questions of facts. Learning used an inquiry approach requires a classroom environment where students feel free to create, make assumptions and draw conclusions. The aim of this research is to determine the improvement in biological science learning outcomes regarding the concept of photosynthesis used a contextual-based inquiry learning approach for class VIII3 students at Junior Hight School Negeri 2 Ambon. This type of research includes descriptive research using a PTK design. This research was conducted at a Junior High School Negeri 2 Ambon. The subjects in this research were students in class VIII3 as many as 26 students. Data analysis uses qualitative data, then the final value is converted using completeness criteria. Based on the tests gived in cycle I, the final test results for each group were not significant. In group I, only 4 students (15.4%) had not reached the completion criteria and 5 other students were able to achieve completion with a percentage (19.2%). The number of students who achieved completeness in group II was 7 students (27.0%), and 2 other students (7.7%) did not achieve completeness. Meanwhile in group III, there were 5 students who were able to achieve completeness with a percentage of (19.2%) and 3 students (11.5%) who did not achieve completeness. Thus, there were 9 students (34.6%) who had not achieved completeness and 17 students (65.4%) had achieved completeness. Meanwhile, in cycle II the test results increased. In group I, there were 5 students who met the completion criteria with a percentage of 19.2%, 4 other students still had not completed it. Group II increased even more, 7 students (27%) met the criteria for completion while 2 students (7.7%) still did not complete. In group III there were 5 students (19.2%) who met the criteria for completion, and 3 other students (11.5%) who still had not completed it. The final test seems to show very good results. The conclusion of the research was taught used a contextual-based inquiry approach to the concept of photosynthesis can improve student learning outcomes, seen in cycle I and cycle II because the cognitive, affective and psychomotor aspects can improved.
42
Purbayanti, Dwi, and Nur Aryanti Rembulan Saputra. "Efek Mengkonsumsi Minuman Beralkohol Terhadap Kadar Triglisrida." Jurnal Surya Medika 3, no. 1 (2017): 75–81. http://dx.doi.org/10.33084/jsm.v3i1.214.
Full textAbstract:
Heavy drinkers who consume more than 30 grams of alcohol per day will increase the risk of increasing triglyceride levels. Chronic ethanol metabolism causes disrupted fatty acid oxidation and the transfer of carbon to fat causes an increase in the production of triglycerides in the liver. The excess triglycerides in the liver are then removed from the blood vessels and there is a buildup of triglycerides in the blood vessels and can progress to Coronary Heart Disease (CHD). This study aims to describe the triglyceride levels in alcohol users on Jalan Mendawai, Palangka Raya City. This study uses a descriptive method to describe triglyceride levels in people who use or consume alcohol on Jalan Mendawai, Palangka Raya City. The number of samples obtained were 20 samples and taken using purposive sampling technique, with criteria that are male sex, more than 20 years old, had consumed alcohol more than 5 years, at least 1 time in 1-week consuming alcohol and willing to be sampled. The results showed that only 1 person (5%) had normal triglyceride levels and 19 people (95%) had normal triglyceride levels. Based on the criteria for the risk of coronary heart disease (CHD) that is 1 person (5%) had triglyceride levels with ideal criteria, 4 people (20%) included in the criteria for high risk of CHD risk, 7 people (35%) which included high-risk criteria and 8 people (40%) which included very high-risk criteria for CHD.
43
Matamay, Zubair, Jamaludin M. Sakung, and Afadil Afadil. "Improving Students' Independent Learning Outcomes and Science Through Discovery Learning." Jurnal Riset Pendidikan MIPA 7, no. 1 (2023): 14–18. http://dx.doi.org/10.22487/j25490192.2023.v7.i1.pp14-18.
Full textAbstract:
This study aims to improve student learning outcomes and independence through discovery learning in science subjects. Class action research methods. In the pre-action, there were 5 students (26.3%) who had fulfilled the KKM and there were 14 students (73.7%) who had not. In cycle I there were 10 students (52.7%) who fulfilled the KKM and 9 students (47.3%) who did not. Student independence was obtained by 12 students (63.16%) with sufficient criteria. and 7 students (36.84%) in less criteria. In cycle II there were 15 students (78.9%) who fulfilled the KKM and 4 students (21.1%) who had not, obtained student independence, namely there were 7 students (36.84%) with good criteria, there were 10 students (52.63 %) was sufficient, and there were 2 students (10.53%) lacking. The percentage of students who scored above the KKM in cycle I was 52.6% and cycle II was 78.9%, this shows that the discovery learning method was able to improve students' science learning outcomes.
44
Chandra, Shanel, Joseph Biederman, and Stephen V. Faraone. "Assessing the Validity of the Age at Onset Criterion for Diagnosing ADHD in DSM-5." Journal of Attention Disorders 25, no. 2 (2016): 143–53. http://dx.doi.org/10.1177/1087054716629717.
Full textAbstract:
Objective: Research about Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) age of onset criterion for ADHD led to increasing that criterion to 12 in Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5). Although an improvement from the previous age at onset of 7, whether this new criterion is adequate to capture all cases with ADHD remains uncertain. Method: We compared three groups of adults: (a) ADHD participants who met all DSM-5 criteria for ADHD ( n = 182), (b) late-onset ADHD participants who met all criteria except for later age at onset ( n = 17), and (c) non-ADHD participants who did not meet criteria for ADHD ( n = 117). We assessed patterns of symptoms, psychiatric comorbidity, functional impairment, familial transmission, quality of life, social adjustment, and intelligence. Results: Compared with non-ADHD participants, all ADHD groups had poorer quality of life and had more impaired social adjustment. Compared with each other, the ADHD groups had similar patterns of psychiatric comorbidity, functional impairment, familial transmission, and intelligence. Conclusion: When assessing adult ADHD, self-reported onsets of ADHD after 12 years of age may be warranted.
45
de Wilde, JA, M. Peters-Koning, and BJC Middelkoop. "Misclassification of stunting, underweight and wasting in children 0–5 years of South Asian and Dutch descent: ethnic-specific v. WHO criteria." Public Health Nutrition 23, no. 12 (2020): 2078–87. http://dx.doi.org/10.1017/s1368980019004464.
Full textAbstract:
AbstractObjective:Several authors have questioned the suitability of WHO Child Growth Standards (WHO-CGS) for all ethnic groups. The aim of this study was to identify potential misclassification of stunting, underweight and wasting in children of Surinamese Asian Indian, South Asian (Pakistan/India) and Dutch descent.Design:A series of routine cross-sectional measurements, collected 2012–2015. South Asian-specific normative growth references for weight-for-age and weight-for-length/height were constructed using the LMS method based on historic growth data of Surinamese Asian Indians born between 1974 and 1976. WHO-CGS and ethnic-specific references were applied to calculate z-scores and prevalence of stunting, underweight and wasting.Setting:Youth HealthCare, providing periodical preventive health check-ups.Participants:11 935 children aged 0–5 years.Results:Considerable deviations from WHO-CGS were found, with higher-than-expected stunting rates, especially in the first 6 months of life. Surinamese Asian Indian children showed stunting rates up to 16·0 % and high underweight and wasting over the whole age range (up to 7·2 and 6·7 %, respectively). Dutch children consistently had mean WHO-CGS z-scores 0·3–0·5 sd above the WHO baseline (>6 months). The application of ethnic-specific references showed low rates for all studied indicators, although South Asian children were taller and larger than their Surinamese Asian Indian counterparts.Conclusions:WHO-CGS misclassify a considerable proportion of children from all ethnic groups as stunted in the first 6 months of life. Underweight and wasting are considerably overestimated in Surinamese Asian Indian children. Ethnic-specific growth references are recommended for Surinamese Asian Indian and Dutch children. The considerable differences found between South Asian subpopulations requires further research.
46
Siahaan, Fernando, Syaiful Anwar, and Felix W Handono. "Simple Additive Weighting to Determine The Best Employee in a Freight Forwarding and Logistics Company." Journal of Computer Networks, Architecture and High Performance Computing 6, no. 3 (2024): 1193–203. http://dx.doi.org/10.47709/cnahpc.v6i3.4244.
Full textAbstract:
The problem is that there is no method used to determine the best employee in the company based on the criteria set by the company. The purpose of this research is to propose simple additive weighting as a method for finding the best employees according to the weighting carried out. To make decisions, there are several criteria and criteria weights that are needed as a measuring tool to assess employees who will be promoted, attendance, QSM, Quiz, leading. Period of work and team work. The weight value of each criterion is attendance 0.20, QSM 0.25, Quiz 0.15, leading 0.20, tenure 0.10 and team work 0.10. Quality service management (QSM) if sub criteria < 200 QSM value 1, sub criteria 201 - 300 QSM value 2, sub criteria 301 - 400 QSM value 3, sub criteria 401 - 500 QSM value 4, sub criteria 501 - 600 QSM value 5. The results of the analysis with the saw method obtained two employees who got the highest score who had the right to be promoted for promotion with a value of 84.25 and 82.25. the conclusion is that the SAW method is influential in supporting and facilitating decision making to determine promoted employees.
47
Petersen, Ronald C., Glenn E. Smith, Stephen C. Waring, Robert J. Ivnik, Emre Kokmen, and Eric G. Tangelos. "Aging, Memory, and Mild Cognitive Impairment." International Psychogeriatrics 9, S1 (1997): 65–69. http://dx.doi.org/10.1017/s1041610297004717.
Full textAbstract:
In recent years, patients who are at high risk for developing Alzheimer's disease (AD) have become a focus of study. Several research groups have identified these patients, developed diagnostic criteria, and followed the patients longitudinally. These patients therefore constitute a clinical entity that is suitable for therapeutic interventions. In this article, we report our 5-year experience at the Mayo Clinic in characterizing a group of patients with mild cognitive impairment. These subjects were recruited from community-dwelling individuals who were receiving general medical care in the Department of Internal Medicine. They received the diagnosis of mild cognitive impairment if they met the following criteria: (a) complaint of defective memory, (b) normal activities of daily living, (c) normal general cognitive function, (d) abnormal memory function for age, and (e) absence of dementia. In following more than 75 of these patients, some of whom have been studied for as long as 5 years, it appears that approximately 10% to 15% of the subjects evolve to AD each year. We therefore evaluated the cognitive profiles of these patients at the time of their initial diagnosis in an attempt to predict who would remain stable and who would evolve to AD. Certain features of learning and memory performance indicated patients who were more likely to progress, but the strongest predictor was their apolipoprotein E status. The patients who possessed an ε4 allele were more likely to convert to AD at a more rapid rate then those who were not carriers. Our results and similar data from other study groups indicate that diagnostic criteria can be defined for patients who are likely to convert to AD; the natural history of these patients is becoming apparent, and variables that predict ultimate conversion can be defined. Consequently, patients with mild cognitive impairment constitute an important group for study, particularly from the aspect of therapeutic interventions.
48
Jain, Deepali, Katayoon B. Ebrahimi, Neil R. Miller, and Charles G. Eberhart. "Intraorbital Meningiomas: A Pathologic Review Using Current World Health Organization Criteria." Archives of Pathology & Laboratory Medicine 134, no. 5 (2010): 766–70. http://dx.doi.org/10.5858/134.5.766.
Full textAbstract:
Abstract Context.—Meningiomas represent approximately 4% of all intraorbital tumors and can arise from the optic nerve or extend into the orbit from adjacent structures. Objective.—To examine a cohort of intraorbital meningiomas and use the current World Health Organization (WHO) scheme to assess the effect of changes to the classification of tumors at this site. Design.—The histopathology and clinical findings of intraorbital meningiomas resected between 1968 and 2008 at our institution were reviewed according to the WHO 2007 classification scheme. Results.—A total of 51 intraorbital meningiomas were reviewed. The mean age at presentation was 45 years, but 5 tumors arose in children. Two patients were known to have neurofibromatosis type 2, and 1 had inherited retinoblastoma. Orbital meningiomas were more frequently encountered in women (30 cases) than in men (21 cases). In 21 patients, the tumor was associated with the optic nerve. The most common (25 of 51 tumors; 49%) histopathologic subtype was meningothelial. Most (47 of 51; 92%) of the tumors were WHO grade I. Four tumors (8%) were WHO grade II, with 4 or more mitotic figures per 10 high-power fields, brain invasion, chordoid histology, or a combination of these features. Conclusions.—Intraorbital meningiomas were most frequently of the meningothelial or transitional subtypes and were WHO grade I. One relatively common intracranial subtype, fibrous meningioma, was not encountered. The percentage of WHO grade II tumors in the orbit (8%) is similar to that reported for intracranial tumors using the current grading scheme.
49
Fu, S. "A phase I study of a hypomethylating agent azacitidine in combination with carboplatin in patients with platinum resistant epithelial ovarian cancer." Journal of Clinical Oncology 24, no. 18_suppl (2006): 5087. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.5087.
Full textAbstract:
5087 Background: Hypermethylation is a common event associated with inactivation of a variety of genes and pathways involved in tumorigenesis and progression as well as drug resistance. Previous evidence displayed that hypomethylating agents could resensitize epithelial ovarian cancer cells to platinum treatment through reexpression of platinum sensitivity-related genes. Therefore, it is of great interest to use a hypomethylating agent to resensitize platinum resistant epithelial ovarian cancer cells to platinum treatment. Methods: This proof-of-concept study used a modified dose-escalation schema (3+3 design). All patients, who have progressed within the 6 months after a platinum-based regimen, are eligible if they have a pathologically confirmed epithelial ovarian cancer. All patients receive subcutaneous injection of azacitidine 75 mg/m2/day for 5 days on days 1–5 and intravenous infusion of carboplatin once on day 2 of each treatment cycle (28 days). Azacitidine is maintained at the same dosage during dose-escalation of carboplatin from AUC4 to AUC5. Results: Six patients have received a total of 16 cycles of treatment. There was no grade 2 or higher toxicity observed. Three patients were evaluable for response: 1 patient, who received 6 cycles of treatment, achieved complete response by CA125 criteria and stable disease by imaging criteria; 1 patient, who received 5 cycles of treatment, displayed stable disease; and the 3rd patient, who received 2 cycles of treatment, showed mixed response by imaging criteria. Conclusions: Preliminary data showed that a regimen of azacitidine 75 mg/m2/day for 5 days plus carboplatin AUC 5 on day 2 was well tolerated in patients with extensive prior treatment. No significant financial relationships to disclose.
50
Ueda, Yuya, Takehiko Matsushita, Yohei Shibata, et al. "Association Between Meeting Return-to-Sport Criteria and Psychological Readiness to Return to Sport After Anterior Cruciate Ligament Reconstruction." Orthopaedic Journal of Sports Medicine 10, no. 5 (2022): 232596712210939. http://dx.doi.org/10.1177/23259671221093985.
Full textAbstract:
Background: The relationship between meeting return-to-sport criteria and psychological readiness after anterior cruciate ligament (ACL) reconstruction is unknown. Purposes: To examine (1) whether patients who met 1 of the criteria for return to sport had higher psychological readiness than those who did not meet any of the criteria and (2) if those who met more criteria had higher psychological readiness. Study Design: Cross-sectional study; Level of evidence, 3. Methods: This study included 144 patients who underwent unilateral ACL reconstruction. All patients had regularly participated in some sport activities before an ACL rupture. At 12 months postoperatively, each patient completed 3 knee function tests (isokinetic quadriceps strength, isokinetic hamstring strength, and single-leg hop distance) and 2 self-reported measures (International Knee Documentation Committee [IKDC] 2000 subjective form and ACL–Return to Sport after Injury [ACL-RSI] scale); the ACL-RSI scale was used to measure psychological readiness to return to sport. The 4 criteria for return to sport were a limb symmetry index (LSI) ≥90% for each of the 3 function tests in addition to an IKDC score ≥90. Multivariate regression analysis was used to determine the association between meeting the individual criteria and the ACL-RSI score. In addition, the patients were divided into 5 groups according to the number of criteria met, and the Kruskal-Wallis and Steel-Dwass tests were used to compare the ACL-RSI scores among the groups. Results: Overall, 23 patients (16.0%) met none of the criteria for return to sport, 27 (18.7%) met 1 of the criteria, 34 (23.6%) met 2 criteria, 35 (24.3%) met 3 criteria, and 25 (17.4%) met all 4 criteria. Meeting the criteria for the hamstring strength LSI ( P = .002), single-leg hop distance LSI ( P = .004), and IKDC subjective score ( P < .001) was each associated with higher ACL-RSI scores. Significant differences in ACL-RSI scores were found between patients who met none versus 2, 3, and 4 of the return-to-sport criteria ( P < .001 for all) and between patients who met 1 versus 4 criteria ( P < .001). Conclusion: Meeting return-to-sport criteria was positively associated with psychological readiness, and the patients who met multiple criteria had higher psychological readiness.