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1

Goodwin, Peter M. "Whole Brain Radiotherapy." Oncology Times 38, no. 19 (2016): 33. http://dx.doi.org/10.1097/01.cot.0000503434.94497.c6.

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M.D (R.T), Dr C. S. K. Prakash. "High Grade Asrtocytomas Whole Brain Radiotherapy (WBRT) vs Limited Volume Brain Radiotherapy (LVBRT)- A Prospective Randomized Study." Journal of Medical Science And clinical Research 04, no. 10 (2016): 13197–208. http://dx.doi.org/10.18535/jmscr/v4i10.66.

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3

Chinnaiyan, Prakash, Emory McTyre, and Jacob Scott. "Whole brain radiotherapy for brain metastasis." Surgical Neurology International 4, no. 5 (2013): 236. http://dx.doi.org/10.4103/2152-7806.111301.

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4

Kaidar-Person, Orit, Carey K. Anders, and Timothy M. Zagar. "Whole Brain Radiotherapy for Brain Metastases." JAMA 316, no. 4 (2016): 393. http://dx.doi.org/10.1001/jama.2016.8692.

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5

Dong, Weiwei, Yun Zhou, Xiangyang Jiang, and Yan Zhou. "Comparative Efficacy of Whole-Brain Radiotherapy Combined with Supplemental Precision Radiotherapy and Whole-Brain Radiotherapy Alone for Brain Metastases." Oncology Treatment Discovery 2, no. 1 (2024): 41–46. http://dx.doi.org/10.26689/otd.v2i1.6294.

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Objective: To investigate the efficacy of whole-brain radiotherapy combined with supplemental precision radiotherapy compared to whole-brain radiotherapy alone for brain metastasis. Methods: Twenty-six cases of patients with brain metastasis were observed from January 2020 to June 2023. Thirteen cases each were randomly assigned to the observation group and the control group. The patients in the observation group received whole-brain radiotherapy combined with supplemental precision radiotherapy, while those in the control group received only whole-brain radiotherapy. Results: Comparing the qu
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6

Rades, Dirk, Susanne Kieckebusch, Tiina Haatanen, Radka Lohynska, Juergen Dunst, and Steven E. Schild. "Surgical Resection Followed by Whole Brain Radiotherapy Versus Whole Brain Radiotherapy Alone for Single Brain Metastasis." International Journal of Radiation Oncology*Biology*Physics 70, no. 5 (2008): 1319–24. http://dx.doi.org/10.1016/j.ijrobp.2007.08.009.

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7

Ho, Andrew, Farasat Kazmi, Hannah Hendry, and Pinelopi Gkogkou. "SURVIVAL OUTCOMES AFTER WHOLE BRAIN RADIOTHERAPY." Neuro-Oncology 25, Supplement_3 (2023): iii19—iii20. http://dx.doi.org/10.1093/neuonc/noad147.083.

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Abstract AIMS Cerebral metastases from extra-cranial primary cancer carries a poor prognosis. For patients in whom surgical resection or SRS are not suitable, local control rates are poor. There is considerable debate surrounding the value of whole brain radiotherapy in this patient cohort in terms of local control, survival and functional status. We aimed to measure survival in patients receiving whole brain radiotherapy at the Norfolk and Norwich University Hospital. METHOD All patients who completed a course of whole brain radiotherapy at our centre between April 2018 and December 2022 were
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8

Chyrmang, Deiwakor, Yumkhaibam S. Devi, Kishalay Baidya, Laishram J. Singh, Daffilyne L. Nongrum, and Ningthoujam D. Devi. "A comparative study of whole brain radiotherapy with concomitant thalidomide versus whole brain radiotherapy alone in brain metastases." Journal of Cancer Research and Therapeutics 20, no. 1 (2023): 255–60. http://dx.doi.org/10.4103/jcrt.jcrt_1724_22.

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Background: Brain metastasis increases morbidity and mortality in cancer patients. This study was undertaken to compare tumor response and treatment-related toxicities in patients treated with orally administered thalidomide concomitantly with whole brain radiotherapy to whole brain radiotherapy alone in brain metastases. Methods: This randomized control trial was conducted in radiation oncology department, RIMS among 42 patients of brain metastases distributed in two study arms during the period August 2018 to July 2020. Twenty patients in Arm-A received whole brain radiotherapy to a dose of
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9

Oskan, F., U. Ganswindt, S. B. Schwarz, F. Manapov, C. Belka, and M. Niyazi. "Hippocampus sparing in whole-brain radiotherapy." Strahlentherapie und Onkologie 190, no. 4 (2014): 337–41. http://dx.doi.org/10.1007/s00066-013-0518-8.

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10

Giubilei, Cesare, Gianluca Ingrosso, Marco D’Andrea, Michaela Benassi, and Riccardo Santoni. "Hypofractionated stereotactic radiotherapy in combination with whole brain radiotherapy for brain metastases." Journal of Neuro-Oncology 91, no. 2 (2008): 207–12. http://dx.doi.org/10.1007/s11060-008-9700-8.

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11

RADES, DIRK, THEO VENINGA, STEFAN JANSSEN, and STEVEN E. SCHILD. "Outcomes After Whole-brain Radiotherapy for Brain Metastases with 5×4 Gy: Importance of Overall Treatment Time." Anticancer Research 36, no. 9 (2016): 4941–46. http://dx.doi.org/10.21873/anticanres.11060.

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12

Khuntia, Deepak, Paul Brown, Jing Li, and Minesh P. Mehta. "Whole-Brain Radiotherapy in the Management of Brain Metastasis." Journal of Clinical Oncology 24, no. 8 (2006): 1295–304. http://dx.doi.org/10.1200/jco.2005.04.6185.

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Brain metastases are an important cause of morbidity and mortality, afflicting nearly 170,000 Americans annually. The prognosis for these patients is poor, with median survival times measured in months. In this review article, we present the standard treatment approach of whole-brain radiotherapy and discuss new directions, including the role of chemical modifiers and the management and prevention of neurocognitive deficits.
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13

Brown, Paul D., Manmeet S. Ahluwalia, Osaama H. Khan, Anthony L. Asher, Jeffrey S. Wefel, and Vinai Gondi. "Whole-Brain Radiotherapy for Brain Metastases: Evolution or Revolution?" Journal of Clinical Oncology 36, no. 5 (2018): 483–91. http://dx.doi.org/10.1200/jco.2017.75.9589.

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An estimated 20% of patients with cancer will develop brain metastases. Approximately 200,000 individuals in the United States alone receive whole-brain radiotherapy (WBRT) each year to treat brain metastases. Historically, the prognosis of patients with brain metastases has been poor; however, with new therapies, this is changing. Because patients are living longer following the diagnosis and treatment of brain metastases, there has been rising concern about treatment-related toxicities associated with WBRT, including neurocognitive toxicity. In addition, recent clinical trials have raised qu
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14

Grob, J. J., J. Regis, R. Laurans, et al. "Radiosurgery without whole brain radiotherapy in melanoma brain metastases." European Journal of Cancer 34, no. 8 (1998): 1187–92. http://dx.doi.org/10.1016/s0959-8049(98)00026-4.

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15

Sneed, Penny K., Kathleen R. Lamborn, Julie M. Forstner, et al. "Radiosurgery for brain metastases: is whole brain radiotherapy necessary?" International Journal of Radiation Oncology*Biology*Physics 43, no. 3 (1999): 549–58. http://dx.doi.org/10.1016/s0360-3016(98)00447-7.

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16

Kocher, Martin, Mohammad Maarouf, Mark Bendel, Juergen Voges, Rolf-Peter Müller, and Volker Sturm. "Linac Radiosurgery Versus Whole Brain Radiotherapy for Brain Metastases." Strahlentherapie und Onkologie 180, no. 5 (2004): 263–67. http://dx.doi.org/10.1007/s00066-004-1180-y.

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17

Fleckenstein**, Katharina, Holger Hof**, Frank Lohr, Frederik Wenz, and Michael Wannenmacher. "Prognostic Factors for Brain Metastases after Whole Brain Radiotherapy." Strahlentherapie und Onkologie 180, no. 5 (2004): 268–73. http://dx.doi.org/10.1007/s00066-004-1234-1.

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18

Okada, Yukinori, Mariko Kobayashi, Mio Shinozaki, et al. "Survival time and prognostic factors after whole-brain radiotherapy of brain metastases from of breast cancer." Acta Radiologica Open 9, no. 7 (2020): 205846012093874. http://dx.doi.org/10.1177/2058460120938744.

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Background Breast cancer has a poor prognosis due to the high risk of distant metastasis. Purpose To identify the prognosticators of brain metastasis from breast cancer treated by whole-brain radiotherapy. Material and Methods We evaluated patients diagnosed with primary brain metastasis without carcinomatous meningitis from breast cancer and had undergone whole-brain radiotherapy as initial treatment between 1 January 2010 and 30 September 2019. We investigated associations between overall survival time from diagnosis using cranial contrast-enhanced magnetic resonance imaging (MRI)/computed t
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19

Ramadan, Islam, Shaaban El-Assal, Mohamed Farouk, Sherif El-zawawy, and Hany El-Deeb. "Comparative Study Evaluating Cognitive Functions in Patients Receiving Conventional Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy." Tumori Journal 107, no. 1_suppl (2021): 16. http://dx.doi.org/10.1177/03008916211016800.

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Background: Whole brain radiotherapy is the treatment of choice for patients with brain metastases. However, neurocognitive functions decline due to impaired hippocampal neurogenesis might occur thereafter. It is hypothesized that conformal hippocampal avoidance during the course of WBRT might provide meaningful neurocognitive functions preservation. Our study aims to demonstrate the impact of delivering HA‑WBRT on NCF changes in patients receiving WBRT. Methods: fifty patients who were referred for cranial irradiation were enrolled in the study. Before the HA‑WBRT course and randomly assigned
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20

Dang Quoc, Soai, Quang Bui Vinh, Cuong Bui Xuan, Toan Hoang Van, and Truong Vu. "Analyzing Planning Techniques for Whole Brain Radiotherapy." International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 09, no. 01 (2020): 1–13. http://dx.doi.org/10.4236/ijmpcero.2020.91001.

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21

Nieder, Carsten, Adelgunde Leicht, Babak Motaref, Ursula Nestle, Marcus Niewald, and Klaus Schnabel. "Late Radiation Toxicity After Whole-Brain Radiotherapy." American Journal of Clinical Oncology: Cancer Clinical Trials 22, no. 6 (1999): 573. http://dx.doi.org/10.1097/00000421-199912000-00007.

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22

Irfan, I., S. Kundan, and D. Ghosh. "PO-0652: Hippocampal avoidance whole brain radiotherapy." Radiotherapy and Oncology 111 (2014): S1. http://dx.doi.org/10.1016/s0167-8140(15)30770-2.

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23

Ferreri, Andrés JM, Lisa DeAngelis, Gerald Illerhaus, et al. "Whole-brain radiotherapy in primary CNS lymphoma." Lancet Oncology 12, no. 2 (2011): 118–19. http://dx.doi.org/10.1016/s1470-2045(11)70018-3.

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24

Kazda, Tomáš, Petr Pospíšil, Hana Doleželová, Radim Jančálek, and Pavel Šlampa. "Whole brain radiotherapy: Consequences for personalized medicine." Reports of Practical Oncology & Radiotherapy 18, no. 3 (2013): 133–38. http://dx.doi.org/10.1016/j.rpor.2013.03.002.

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25

Mehta, Minesh P., Hidefumi Aoyama, and Vinai Gondi. "The Changing Role of Whole-Brain Radiotherapy." JAMA Oncology 3, no. 8 (2017): 1021. http://dx.doi.org/10.1001/jamaoncol.2016.5414.

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26

D’Agostino, Giuseppe Roberto, Rosa Autorino, Angelo Pompucci, et al. "Whole-Brain Radiotherapy Combined with Surgery or Stereotactic Radiotherapy in Patients with Brain Oligometastases." Strahlentherapie und Onkologie 187, no. 7 (2011): 421–25. http://dx.doi.org/10.1007/s00066-011-2228-4.

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27

Duan, Lei, Rong Zeng, Ke-Hu Yang, et al. "Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis." Asian Pacific Journal of Cancer Prevention 15, no. 2 (2014): 911–15. http://dx.doi.org/10.7314/apjcp.2014.15.2.911.

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28

Li, L., M. Feng, P. Xu, et al. "Whole brain radiotherapy plus simultaneous in-field boost versus whole brain radiotherapy plus fractionated stereotactic radiotherapy for multiple brain metastases of non-small cell lung cancer." Annals of Oncology 30 (October 2019): v149. http://dx.doi.org/10.1093/annonc/mdz243.018.

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29

la Fuente, Macarena de, Kathryn Beal, Richard Carvajal, and Thomas J. Kaley. "Whole-brain radiotherapy in patients with brain metastases from melanoma." CNS Oncology 3, no. 6 (2014): 401–6. http://dx.doi.org/10.2217/cns.14.40.

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30

Nieder, Carsten. "Influence of Whole-Brain Radiotherapy on Remission of Brain Metastases." Journal of Clinical Oncology 24, no. 24 (2006): 4037. http://dx.doi.org/10.1200/jco.2005.05.1185.

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31

Akiba, T., E. Kunieda, A. Kogawa, T. Komatsu, Y. Tamai, and Y. Ohizumi. "Re-irradiation for Metastatic Brain Tumors with Whole-brain Radiotherapy." Japanese Journal of Clinical Oncology 42, no. 4 (2012): 264–69. http://dx.doi.org/10.1093/jjco/hys007.

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32

Pechoux, Cécile Le, Frederic Dhermain, and Benjamin Besse. "Whole brain radiotherapy in patients with NSCLC and brain metastases." Lancet 388, no. 10055 (2016): 1960–62. http://dx.doi.org/10.1016/s0140-6736(16)31391-5.

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33

Kondziolka, Douglas, Ajay Niranjan, John C. Flickinger, and L. Dade Lunsford. "Radiosurgery With or Without Whole-Brain Radiotherapy for Brain Metastases." American Journal of Clinical Oncology 28, no. 2 (2005): 173–79. http://dx.doi.org/10.1097/01.coc.0000143016.15783.5b.

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34

Vermeulen, Sandra S. "Whole brain radiotherapy in the treatment of metastatic brain tumors." Seminars in Surgical Oncology 14, no. 1 (1998): 64–69. http://dx.doi.org/10.1002/(sici)1098-2388(199801/02)14:1<64::aid-ssu8>3.0.co;2-0.

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35

Lynch, Meghan. "Preservation of cognitive function following whole brain radiotherapy in patients with brain metastases: Complications, treatments, and the emerging role of memantine." Journal of Oncology Pharmacy Practice 25, no. 3 (2018): 657–62. http://dx.doi.org/10.1177/1078155218798176.

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Whole brain radiotherapy is the mainstay of treatment for patients suffering from stage IV malignancies that have metastasized to the brain. Although this therapy is often effective at reducing tumor size and burden, it is associated with a spectrum of toxicities that often result in irreversible cognitive decline. Various drug and non-drug therapies have been evaluated to treat this neurotoxicity after whole brain radiotherapy is administered; however, currently available options have shown little benefit or come with side effects themselves that may outweigh the benefits of their use. For th
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36

Madden, Kathleen. "Identifying and Managing Complications of Whole Brain Radiotherapy." Clinical Journal of Oncology Nursing 13, no. 4 (2009): 446–48. http://dx.doi.org/10.1188/09.cjon.446-448.

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37

DeAngelis, L. M. "Whither whole brain radiotherapy for primary CNS lymphoma?" Neuro-Oncology 16, no. 8 (2014): 1032–34. http://dx.doi.org/10.1093/neuonc/nou122.

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38

Wang, Shuo, Dandan Zheng, Chi Zhang, et al. "Automatic planning on hippocampal avoidance whole-brain radiotherapy." Medical Dosimetry 42, no. 1 (2017): 63–68. http://dx.doi.org/10.1016/j.meddos.2016.12.002.

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39

Zhao, Ren, Wei Kong, Jun Shang, Hong Zhe, and Yan-Yang Wang. "Hippocampal-Sparing Whole-Brain Radiotherapy for Lung Cancer." Clinical Lung Cancer 18, no. 2 (2017): 127–31. http://dx.doi.org/10.1016/j.cllc.2016.09.007.

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40

Lutz, Stephen. "Palliative whole-brain radiotherapy fractionation: Convenience versus cognition?" Cancer 110, no. 11 (2007): 2363–65. http://dx.doi.org/10.1002/cncr.23069.

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41

Kondziolka, Douglas, Atul Patel, L. Dade Lunsford, Amin Kassam, and John C. Flickinger. "Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases." International Journal of Radiation Oncology*Biology*Physics 45, no. 2 (1999): 427–34. http://dx.doi.org/10.1016/s0360-3016(99)00198-4.

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42

Yuan, Xi, Wen-Jie Liu, Bing Li, Ze-Tian Shen, Jun-shu Shen, and Xi-Xu Zhu. "A Bayesian network meta-analysis of whole brain radiotherapy and stereotactic radiotherapy for brain metastasis." Medicine 96, no. 34 (2017): e7698. http://dx.doi.org/10.1097/md.0000000000007698.

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43

Miura, Kosei, Hiromasa Kurosaki, Nobuko Utsumi, and Hideyuki Sakurai. "Use of a Head-Tilting Baseplate During Tomotherapy to Shorten the Irradiation Time and Protect the Hippocampus and Lens in Hippocampal Sparing-Whole Brain Radiotherapy." Technology in Cancer Research & Treatment 20 (January 1, 2021): 153303382098682. http://dx.doi.org/10.1177/1533033820986824.

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Purpose: The aim of this study is to comparatively examine the possibility of reducing the exposure dose to organs at risk, such as the hippocampus and lens, and improving the dose distribution of the planned target volume with and without the use of a head-tilting base plate in hippocampal-sparing whole-brain radiotherapy using tomotherapy. Methods: Five paired images of planned head computed tomography without and with tilt were analyzed. The hippocampus and planning target volume were contoured according to the RTOG 0933 contouring atlas protocol. The hippocampal zone to be avoided was deli
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44

Kim, Michelle M., Hemant Parmar, Yue Cao, et al. "Concurrent whole brain radiotherapy and RRx-001 for melanoma brain metastases." Neuro-Oncology 18, no. 3 (2016): 455–56. http://dx.doi.org/10.1093/neuonc/nov317.

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45

Hoffmann, Christian, Luitpold Distel, Stefan Knippen, et al. "Brain volume reduction after whole-brain radiotherapy: quantification and prognostic relevance." Neuro-Oncology 20, no. 2 (2017): 268–78. http://dx.doi.org/10.1093/neuonc/nox150.

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46

Jiang, Cecilia, Jeffrey M. Switchenko, David H. Lawson, Melinda Lynne Yushak, and Mohammad Khurram Khan. "Institutional outcomes of whole brain radiotherapy for metastatic melanoma brain metastases." Journal of Clinical Oncology 38, no. 15_suppl (2020): e14504-e14504. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e14504.

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e14504 Background: The management of melanoma with multiple brain metastases (MBM) is complex given improvements in targeted agents, immunotherapy, and radiotherapy. Whole brain radiation therapy (WBRT) is a radiotherapy technique with limited outcomes data. We report our institutional outcomes for MBM patients receiving WBRT and assess whether certain clinical factors impact prognosis. Methods: A retrospective review of a single institution database was performed. Patients diagnosed with MBM from 2000-2018 treated with WBRT, with or without systemic treatments, were included. Post-WBRT brain
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47

Wygoda, M., I. Ospovat, A. Wygoda, N. Adika, and Y. Shoshan. "PO-0773 STEREOTACTIC RADIOSURGERY WITHOUT WHOLE BRAIN RADIOTHERAPY FOR BRAIN METASTASES." Radiotherapy and Oncology 103 (May 2012): S299. http://dx.doi.org/10.1016/s0167-8140(12)71106-4.

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48

Fogarty, Gerald B., Angela Hong, and John F. Thompson. "Should patients with melanoma brain metastases receive adjuvant whole-brain radiotherapy?" Lancet Oncology 16, no. 5 (2015): e195-e196. http://dx.doi.org/10.1016/s1470-2045(15)70183-x.

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49

Pulenzas, Natalie, Luluel Khan, May Tsao, et al. "Fatigue scores in patients with brain metastases receiving whole brain radiotherapy." Supportive Care in Cancer 22, no. 7 (2014): 1757–63. http://dx.doi.org/10.1007/s00520-014-2140-4.

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50

Rades, Dirk, Jasmin N. Evers, Theo Veninga, Lukas J. A. Stalpers, Radka Lohynska, and Steven E. Schild. "Shorter-Course Whole-Brain Radiotherapy for Brain Metastases in Elderly Patients." International Journal of Radiation Oncology*Biology*Physics 81, no. 4 (2011): e469-e473. http://dx.doi.org/10.1016/j.ijrobp.2011.01.058.

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