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Journal articles on the topic 'Wistar Albino'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Amalraj, JulieChristy, N. Charanya, Saraswathi Perumal, and V. Sathialakshmi. "Effect of Kenacort on pregnant Wistar albino rats." Annals of Maxillofacial Surgery 9, no. 2 (2019): 253. http://dx.doi.org/10.4103/ams.ams_141_16.

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2

K., Ahmed S., Chakrapani Cheekavolu, Sampath D., and Sunil M. "Evaluation of antidiabetic activity of fruit of Coriandrum sativum. Linn methanolic extract in Streptozocin induced diabetic wistar Albino rats." International Journal of Basic & Clinical Pharmacology 7, no. 1 (December 23, 2017): 121. http://dx.doi.org/10.18203/2319-2003.ijbcp20175686.

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Background: Diabetes prevalence is estimated to increase annually. Numerous people use traditional medicine, such as India also considered as the diabetic capital in the world. Diabetes is a metabolic disorder characterized by disturbances in lipid, carbohydrate and protein metabolism. The present study to evaluate the antidiabetic potential of coriandrum sativum. linn fruits methanolic extract in streptozocin induced diabetic wistar albino rats model.Methods: Diabetes induction in wistar albino rats by administration of streptozocin (50mg/kg, i.p.) in citrate buffer. 30 wistar albino rats were divided into 5 groups (A, B, C, D, E). Group A: served as normal control, whereas Group B: diabetic control, Group C, D methanolic coriandrum sativum Linn. fruits extract (CSFME) at a dose of 100, 200mg/kg orally, Group E was given standard drug Glibenclamide (0.5mg/kg) orally. All groups are administered for the period of 14 consecutive days and blood sugar levels was measured at regular intervals up to end of the study.Results: This present research study confirms that the test drug compound CSFME has sustained oral hypoglycaemic activity and statistically significant (p ≤0.05) and which is comparable with standard drug Glibenclamide.Conclusions: This research study confirms that the CSFME has antidiabetic activity against streptozocin induced wistar diabetic albino rats. It could be a novel antidiabetic agent and also a dietary adjunct in the type 2 diabetes management and its complication. Further studies are necessary required to confirm the antidiabetic activity of individual phytochemical compounds of Coriandrum sativum.

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3

Wardani, Giftania, Mahmiah Mahmiah M, and Sri Agus Sudjarwo. "Immunostimulatory Activity of Chitosan Nanoparticles on Wistar Albino Rats." Pharmacognosy Journal 10, no. 5 (July 31, 2018): 892–98. http://dx.doi.org/10.5530/pj.2018.5.150.

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4

Sadanandan, Neethu N., Archana R, Sai Sailesh Kumar, Mukkadan J K, and Antony N J. "ANTIHYPERLIPIDEMIC EFFECT OF VESTIBULAR STIMULATION IN WISTAR ALBINO RATS." International Journal of Research in Ayurveda and Pharmacy 6, no. 4 (July 13, 2015): 509–12. http://dx.doi.org/10.7897/2277-4343.06496.

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5

Choudhary, Arbind Kumar, Lognatahan Sundareswaran, and Rathinasamy Sheela Devi. "Aspartame induced cardiac oxidative stress in Wistar albino rats." Nutrition Clinique et Métabolisme 30, no. 1 (March 2016): 29–37. http://dx.doi.org/10.1016/j.nupar.2016.01.071.

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6

Abuelgasim, Afaf I., Rehab Omer, and B. Elmahdi. "Serrobiochemical Effects of Potassium Bromate on Wistar Albino Rats." American Journal of Food Technology 3, no. 5 (August 15, 2008): 303–9. http://dx.doi.org/10.3923/ajft.2008.303.309.

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7

Psilovikos. "Erythropoietin-Like Effects of Dihydroartemisinin in Wistar Albino Rats." American Journal of Agricultural and Biological Sciences 6, no. 4 (April 1, 2011): 511–16. http://dx.doi.org/10.3844/ajabssp.2011.511.516.

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8

Kapgate, Sarita M., and Abhijit B. Patil. "STANDARDIZATION OF MODEL OF INDUCTION OF HEPATOTOXICITY WITH ANTI-TUBERCULOSIS DRUGS IN WISTAR ALBINO RATS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 6 (June 1, 2017): 150. http://dx.doi.org/10.22159/ajpcr.2017.v10i6.11971.

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Objective: The objective of the study to standardize the model of hepatotoxicity induced by ATT drugs in Wistar Albino rats. Isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA), the first line drugs used in the treatment of tuberculosis (TB) associated with the potential adverse effect. Numerous animal studies were reported endeavoring induction and cure of anti-TB (ATT) drug-induced hepatotoxicity using herbal and chemical drugs. However, the previous reported study failed to replicate where Wistar albino rats were treated with INH, RMP, and PZA and had shown the significant development of liver injury. Hence in present paper, aimed to develop a standardize model of induction of hepatotoxicity with ATT drugs.Methods: Wistar rats were treated with ATT drugs in combination in various doses up to 4-8 weeks. Total nine experiments were conducted to achieve successful hepatotoxicity. The aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were the biochemical parameters of assessment. Histopathological changes in the liver were also examined.Results: No evidence of any liver injury or an inflammatory infiltrate has been observed as had been reported in the previous studies. Rather decrease in serum ALT levels has been observed by researcher. In short, hepatic injury cannot be developed with the doses used in previous reported papers. The successful attempt to induce hepatotoxicity can be achieved with the doses of INH - 100, RMP - 300, PZA - 700 mg/kg. The findings were confirmed by the raised ALT, AST, and ALP levels compared with baseline. The histopathological changes also support the findings.Conclusion: The dose of INH - 100, RMP – 300 and PZM - 700 mg/kg. Succeeds to induce hepatotoxicity in Wistar albino rats and Swiss albino mice as well.

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9

Ghori, Syed Safiullah, Tahreen Shazia Siddiqua, and Anees Fathima. "Nephroprotective Effect of Ficus Dalhousiae Miq Leaf Methanolic Extract in Albino Wistar Rats." International Journal of Pharma Research and Health Sciences 4, no. 5 (2016): 1394–98. http://dx.doi.org/10.21276/ijprhs.2016.05.10.

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10

Gautam, Swetlana, Priyanka Singh, Manjari Singh, Subhadeep Roy, Jitendra K. Rawat, Rajnish K. Yadav, Uma Devi, Pushpraj S. Gupta, Shubhini A. Saraf, and Gaurav Kaithwas. "Rifaximin, a pregnane X receptor (PXR) activator regulates apoptosis in a murine model of breast cancer." RSC Advances 8, no. 7 (2018): 3512–21. http://dx.doi.org/10.1039/c7ra09689e.

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11

Oliveira, Paula Alexandra, and Ana Faustino Ana Faustino. "A história do rato de laboratório: do ódio ao amor." História da Ciência e Ensino: construindo interfaces 20 (December 29, 2019): 115–25. http://dx.doi.org/10.23925/2178-2911.2019v20espp115-125.

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ResumoO rato está na base de importantes descobertas na área da medicina. Contudo, nem sempre foi bem visto pela sociedade. No século XIV abateu-se sobre a Europa uma pandemia, a Peste Negra, causada por uma bactéria (Yersinia pestis) transmitida ao Homem por uma pulga (Xenopsylla cheopis), cujo hospedeiro era o rato (Rattus rattus). Esta doença vitimou aproximadamente 150 milhões de pessoas. Estava-se longe de imaginar o contributo que o rato viria a ter na saúde humana.No século XVII o rato proliferou descontroladamente, surgindo uma nova profissão: os caçadores de ratos. Estes indivíduos ganhavam dinheiro com a captura e venda destes animais para alimentação. Nessa época apareceu um desporto novo e as apostas a ele associadas: as lutas de ratos. Como resultado desse desporto, aumentaram os acasalamentos consanguíneos e surgiram variações na pelagem do rato, aparecendo os primeiros ratos albinos. Em 1828 foram utilizados os primeiros ratos albinos num ensaio experimental sobre o estudo do efeito do jejum. Mais tarde, em 1906, no Instituto Wistar, Helen Dean King desenvolveu uma estirpe a partir dos ratos albinos, designada de Wistar, para uso na investigação biomédica.Ainda no século XX o uso do rato de laboratório alargou-se a estudos de aprendizagem em labirinto, nutrição, reprodução, genética e cancro, e consequentemente mais estirpes de animais foram desenvolvidas, passando a existir empresas com o propósito de os vender para investigação. A importância desta espécie pode comprovar-se pela análise do número de artigos publicados anualmente com recurso à sua utilização. Neste trabalho apresenta-se uma revisão histórica do uso do rato na investigação, evidenciando-se as caraterísticas que fizeram deste animal um modelo único na pesquisa biomédica. Palavras-chave: Investigação, Peste Negra, Rattus rattus, Wistar Abstract The rat is the basis of important findings in Medicine. However, it was not always well-seen by the society. In the 14th century, the Europe was affected by a pandemic disease, Black Pestis, caused by a bacterium (Yersinia pestis) transmitted to the Man by a flea (Xenopsylla cheopis), whose host was the rat (Rattus rattus). This disease victimized approximately 150 million people. It was far from imaging the contribution that the rat would have for human health. In the 17th century, the rat proliferated wildly, emerging a new job: the rat hunters. These people earnt money with the capture and selling of these animals for food. At that time appeared a new sport and the bets associated to it: the rat fights. Because of this new hobby, the consanguineous mating increased and appeared variations on rat coat, appearing the first albino rats. In 1828 the albino rats were used by the first time in an experimental assay about the fasting effects. Later, in 1906, in the Wistar Institute, Helen Dean King developed a strain from albino rats, called Wistar, for use in biomedical research. Still in the 20th century, the use of laboratory rats was expanded to studies of learning, nutrition, reproduction, genetics and cancer, and consequently more strains were developed by companies with the purpose to sell them for research. The importance of this specie may be evidenced by the analysis of the number of scientific works published annually using it. In this work, a historical review of the use of the rat in the investigation is provided, evidencing the characteristics that made it a unique model in biomedical research. Keywords: Black Pestis, Investigation, Rattus rattus, Wistar

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12

TK, Hafis, Shyamjith Manikkoth, Melinda Sequeira, and Roopa P. Nayak. "Pharmacological evidence for the anticonvulsant activity of Tylophora indica in experimental animal models." International Journal of Basic & Clinical Pharmacology 6, no. 4 (March 25, 2017): 750. http://dx.doi.org/10.18203/2319-2003.ijbcp20171029.

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Background: Epilepsy is a common neurological disorder. The antiepileptic drugs currently used are unable to manage seizures effectively and are associated with numerous adverse drug effects. Hence, there is a necessity of a newer anticonvulsant drug with high therapeutic index profile. The objective of this pre-clinical research was to investigate the role of Tylophora indica on Maximal electric shock [MES] and Pentylene tetrazole [PTZ] provoked convulsions in Wistar albino rats.Methods: 36 Wistar albino rats were used for this study, after obtaining ethical clearance. The ethanolic extract of the leaves of Tylophora indica [TIEE] (100 mg/kg, p.o) was used to screen the anticonvulsant effect on MES and PTZ provoked convulsions in Wistar albino rats. In MES seizures, inhibition of the tonic hind limb extension and in PTZ seizures, extent of convulsions was noted.Results: TIEE (100 mg/kg, p.o) significantly (p<0.001) blocked the hind limb extension due to MES. The same dose also significantly (p<0.001) lessened the extent of convulsions induced by PTZ.Conclusions: The data suggests that the ethanolic extract of Tylophora indica leaves produce its anticonvulsant effect via different mechanisms since it prevented the hind limb extension induced by MES and decreased the duration of convulsions produced by PTZ.

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13

K, Sujeethasai, Manoharan A, and Santhanakumar M. "Anti-Hypertensive Activity of Hydro Alcoholic Extract of Cìraka Cūraṇam on High Salt Loaded Wistar Albino Rats." International Journal of Research and Review 8, no. 5 (May 10, 2021): 110–15. http://dx.doi.org/10.52403/ijrr.20210516.

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Background: Hypertension is called as Silent killer. The most important risk factor for heart diseases and stroke and it may leads to premature death. Several medicinal plants have high effective in anti-hypertensive and anti-thrombotic activity without any side effects. Aim: To evaluate the anti-hypertensive activity of hydro alcoholic extract of Cìraka cūraṇam on deoxycorticosterone acetate (DOCA) salt induced wistar albino rats. Study design: Observational in-vivo study Place and duration of study: Animal house, Dept. of Pharmacology, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Srivilliputtur,Tamilnadu. Materials and methods: Antihypertensive activity was conducted on wistar albino rats by determining serum Sodium and Potassium levels by using semi auto analyzer (RA-50, Bayer Diagnostics), using specific kits (Auto span, India) at 500 and 550 nm respectively and left carotid artery (for recording BP) was cannulated under aseptic conditions with polyethylene cannula filled with 1% heparin in normal saline. Rest procedure, which was stated under the 2K1C-model was followed and BP was observed in terms of mm of Hg. Results: The Cìraka cūraṇam possesses strong antihypertensive effect against DOCA-salt hypertensive rats, which is evidenced by a considerable decrease in blood pressures. Keywords: Anti-hypertensive activity, Cìraka cūraṇam, Wistar albino rats, Deoxycorticosterone acetate.

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14

Tanwar, Beenu, Rajni Modgil, and Ankit Goyal. "Antinutritional factors and hypocholesterolemic effect of wild apricot kernel (Prunus armeniacaL.) as affected by detoxification." Food & Function 9, no. 4 (2018): 2121–35. http://dx.doi.org/10.1039/c8fo00044a.

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Detoxification treatment substantially reduced antinutritional factors along with the complete removal of hydrocyanic acid from wild (bitter) apricot kernel and improved the hypocholesterolemic effect in male Wistar albino rats.

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15

Chowta, MuktaN, Rakshita Maskeri, Amrita Rai, Ahasan Shoeb, V. Venkatesh, and Vani Bhagwat. "Evaluation of anxiolytic activity of vanillin in wistar albino rats." International Journal of Nutrition, Pharmacology, Neurological Diseases 3, no. 2 (2013): 96. http://dx.doi.org/10.4103/2231-0738.112828.

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16

Arunagiri, Thilakavathi, Arjun Pandian, and Samiraj Ramesh. "Hypocholesterolemic Effect of Dietary Fish Oil in Albino Wistar Rats." Research Journal of Pharmacy and Technology 12, no. 9 (2019): 4161. http://dx.doi.org/10.5958/0974-360x.2019.00718.2.

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17

Chanda, Sumitra, Rajeshkumar Dave, Mital Kaneria, and Vinay Shukla. "Acute oral toxicity ofPolyalthia longifoliavar.pendulaleaf extract in Wistar albino rats." Pharmaceutical Biology 50, no. 11 (September 11, 2012): 1408–15. http://dx.doi.org/10.3109/13880209.2012.682117.

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18

Uchechukwu. "Respiratory Tract-Widening Effects of Dihydroartemisinin in Wistar Albino Rats." American Journal of Pharmacology and Toxicology 6, no. 2 (February 1, 2011): 46–48. http://dx.doi.org/10.3844/ajptsp.2011.46.48.

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19

R, Kavitha, Kannan R, and Glory I. "Selected neurobehavioural evaluation of Leucas Aspera in wistar albino rats." International Journal of Basic & Clinical Pharmacology 2, no. 4 (2013): 433. http://dx.doi.org/10.5455/2319-2003.ijbcp20130817.

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20

Ishola, AjibolaAbdulrahamon. "Exposure to aflatoxin and aggressive behavior among wistar albino rats." Journal of Neurobehavioral Sciences 7, no. 2 (2020): 72. http://dx.doi.org/10.4103/jnbs.jnbs_9_20.

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21

Nayak, Roopa P., Prabhakar Adake, and Hafis T. K. "Antidepressant activity of Trigonella foenum leaves in Wistar albino rats." International Journal of Basic & Clinical Pharmacology 8, no. 5 (April 23, 2019): 963. http://dx.doi.org/10.18203/2319-2003.ijbcp20191584.

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Background: To evaluate antidepressant activity of ethanolic extract of Trigonella foenum in animal models.Methods: A total of 60 healthy male Wistar albino rats weighing 220-250 grams were used and they were divided into 10 groups of 6 rats in each. First five groups (1st -5th) were evaluated by Forced Swim Test (FST) and remaining by Tail Suspension Test (TST). 1st group (control) received normal saline 10 mg/kg, 2nd group (standard) Imipramine 10 mg/kg and 3rd, 4th and 5th groups (test) respectively received Trigonella foenum leaf ethanolic extract [TFEE] in different doses 100 mg, 200 mg, and 400 mg/kg per orally for 14 days. They were evaluated for antidepressant activity using FST after 60 minutes of drug administration on 14th day. Similarly, remaining five groups (6th to 10th) received the same drugs and evaluated using TST after 60 minutes of drug administration. Duration of immobility was noted for six minutes for each rat.Results: One way ANOVA and Tukey Krammer test were used for statistical analysis. The immobility periods were expressed in mean±SD. The immobility period in FST were 207.16±28.7, 50.08±2.9, 46.14±1.2, 40.5±3.4 and 40.0±3.6 seconds respectively for control, standard and three test groups of TFEE (100/200/400 mg/kg). Similarly, immobility periods of 163.11±31.9, 125.03±11.2, 138.81±16.44, 138.16±12.65, 127.58±4.3 seconds were noted for TST for remaining six groups. It was found that TFEE possess statistically significant (p<0.05) antidepressant activity, as evidenced by decrease in the immobility time in both the tests when compared to control group.Conclusions: Present study results demonstrated that TFEE possess antidepressant property in experimental models of depression.

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22

Das, Smita, Jayanti Prava Behera, Y. Rojaramani, and Rashmi Ranjan Mohanty. "Effect of resveratrol on diabetic neuropathy in wistar albino rats." International Journal of Basic & Clinical Pharmacology 9, no. 1 (December 24, 2019): 16. http://dx.doi.org/10.18203/2319-2003.ijbcp20195635.

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Background: Type 2 diabetes mellitus (DM) is a common chronic disease with increasing prevalence worldwide. Prolonged uncontrolled hyperglycemia, dyslipidemia are major risk factor for its complication like neuropathy. Since there is no definite treatment for diabetic neuropathy, this study aims to evaluate the effect of resveratrol on diabetic neuropathy in high fat diet with low dose streptozotocin induced type-2 DM model in wistar albino rats.Methods: First type 2 diabetic rat model was established. Wistar albino rats, fed with high-fat diet (HFD) rendered diabetic with streptozotocin, were divided into 6 groups, disease control (DC) treated with vehicle, standard control (SC) which received metformin, test groups treated with 5, 10, and 20 mg/kg b.w. of resveratrol and combination of half dose of metformin and resveratrol (10 mg/kg) (TC). A group of six normal animals served as normal control (NC), another six as HFD control. Fasting plasma glucose, lipid profile were measured one week after induction of diabetes. The animals were then treated orally for 2 weeks after which the same parameters were repeated. Behavioral biomarkers for neuropathy are measured in 4 weeks and 6 weeks of treatment. The in-vivo results were analyzed by one way ANOVA followed by Tukey’s multiple comparison test for biochemical parameters and Kruskal Wallis test followed by Dun’s multiple comparison test for behavioral biomarkers.Results: Increase in fasting plasma glucose (FPG), deranged lipid profile, increased neuropathy in DC compared to NC, HFD control while a significant decrease in FBG, improved pain behavior with SC, test groups (p<0.05) as compared to the DC group.Conclusions: Resveratrol prevents diabetic neuropathy.

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23

Sujith, K., C. Ronald Darwin, Sathish, and V. Suba. "Memory-enhancing activity of Anacyclus pyrethrum in albino Wistar rats." Asian Pacific Journal of Tropical Disease 2, no. 4 (August 2012): 307–11. http://dx.doi.org/10.1016/s2222-1808(12)60067-x.

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24

Niu, Xiaoli, Siyuan Li, Simin Zheng, Hongfei Xiong, Junlin Lv, Huijuan Zhang, and Hongtao Liu. "Hypoxia-induced brain cell damage in male albino wistar rat." Saudi Journal of Biological Sciences 25, no. 7 (November 2018): 1473–77. http://dx.doi.org/10.1016/j.sjbs.2017.03.018.

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25

Umap, Swati A., Chandrakant R. Jangde, Vijeyta Tiwari, R. P. Limsay, A. Jahan, A. G. Bhandarkar, and N. V. Kurkure. "Amelioration of Dimethoate-induced toxicity byMorinda citrifoliain Wistar albino rats." Indian Journal of Veterinary Pathology 38, no. 4 (2014): 244. http://dx.doi.org/10.5958/0973-970x.2014.01185.7.

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26

Aprioku, S. "Maternal lead exposure and pregnancy outcome in Wistar albino rats." Journal of Toxicology and Environmental Health Sciences 5, no. 10 (December 31, 2013): 185–93. http://dx.doi.org/10.5897/jtehs2013.0279.

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27

Modo, Emmanuel, Friday Uboh, Margaret Agiang, and Efosa Ewere. "Exposure to uppercott induces hepatotoxicity in male albino wistar rats." International Journal of Scientific World 5, no. 1 (April 12, 2017): 74. http://dx.doi.org/10.14419/ijsw.v5i1.7442.

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Background: The use of herbicides and pesticides in agriculture and for public health purposes has led to harmful effects in many non-target species including man.Methods: In this study, the hepatic effect of exposure to cypermethrin and dimethoate mixture (uppercott) was investigated in male albino wistar rats. Forty five (45) male wistar albino rats were distributed into five (5) groups of nine (9) animals each. Groups 1 and 2 served as the normal control and oil control respectively, groups 3, 4 and 5 received 2.5%, 5% and 7.5% LD50 of uppercott orally for 28 days.Results: Results obtained revealed that uppercott exposure significantly (p<0.05) increased serum aspartate aminotransferase (AST) activity, alanine aminotransferase (ALT) activity and alkaline phosphatase (ALP) activity when the test groups were compared with control. Also, uppercott exposure raised serum bilirubin concentration slightly insignificantly compared to the control. Superoxide dismutase activity was significantly reduced across all test groups as compared with compared with control. Histology of liver tissues revealed patchy necrotic sessions in the liver tissues of the test experimental groups (2.5%, 5% and 7.5%).Conclusion: The results obtained from this study are strongly indicative of the hepatotoxic effect of uppercott pesticide and hence, caution during usage is advised.

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Obeten, Kebe E., Roseline P. Ekpefiong, and Charles C. Mfem. "Serum Biochemistry of Albino Wistar Rats Treated With Tobacco Diet." IOSR Journal of Pharmacy and Biological Sciences 9, no. 1 (2014): 68–70. http://dx.doi.org/10.9790/3008-09166870.

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El-Sayyad, Hassan I. H., Soad A. Khalifa, Fawkia I. El-Sayyad, Asma S. AL-Gebaly, Ahmed A. El-Mansy, and Ezaldin AM Mohammed. "Aging-related changes of optic nerve of Wistar albino rats." AGE 36, no. 2 (September 1, 2013): 519–32. http://dx.doi.org/10.1007/s11357-013-9580-5.

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30

Kovács, Zsolt, Renáta Krisztina Lakatos, János Barna, and Árpád Dobolyi. "Absence epileptic activity in Wistar Albino Glaxo Rijswijk rat mothers." Brain Research 1657 (February 2017): 368–76. http://dx.doi.org/10.1016/j.brainres.2017.01.005.

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Aprioku, Jonah Sydney, Barikpoar Ebenezer, and Maxwell Azubuike Ijomah. "Toxicological effects of cadmium during pregnancy in Wistar albino rats." Toxicology and Environmental Health Sciences 6, no. 1 (March 2014): 16–24. http://dx.doi.org/10.1007/s13530-014-0183-z.

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32

Ogunmoyole, Temidayo, Funmilola Comfort Oladele, Ayonbo Aderibigbe, and Olaitan Daniel Johnson. "Hepatotoxicity of Telfaria occidentalis root extracts on wistar albino rat." Heliyon 5, no. 5 (May 2019): e01617. http://dx.doi.org/10.1016/j.heliyon.2019.e01617.

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33

Kovács-Valasek, Andrea, Etelka Pöstyéni, Viktória Dénes, Adrienn Mester, György Sétáló Jr., and Róbert Gábriel. "Age-Related Alterations of Proteins in Albino Wistar Rat Retina." Cells Tissues Organs 210, no. 2 (2021): 135–50. http://dx.doi.org/10.1159/000515447.

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Imbalance of homeostasis causes permanent changes in the body with time. The central nervous system is especially prone to these changes since it possesses limited regenerative capacity. In the retina, neurons are damaged during the aging process, and this eventually leads to deterioration of vision. In our 2-year-long study, we examined genetically closely related rat individuals to disclose the hidden retinal causes of age-associated visual dysfunction. Morphometric analysis showed significant reduction of the retina thickness with aging, particularly that of the inner plexiform layer. To reveal changes between the age groups, we used immunohistochemistry against vesicular glutamate transporter 1 protein for photoreceptor and bipolar cell terminals, Brn3a for ganglion cells, calbindin 28 kDa for horizontal cells, parvalbumin for AII amacrines, protein kinase Cα for rod bipolar cells, tyrosine hydroxylase for dopaminergic cells, glial fibrillary acidic protein for glial cells, and peanut-agglutinin labeling for cones. The most significant decrease was observed in the density of photoreceptor and the ganglion cells in the aging process. By using immunocytochemistry and western blot technique, we observed that calbindin and vesicular glutamate transporter 1 protein staining do not change much with aging; tyrosine hydroxylase, parvalbumin and calretinin showed the highest immunoreactivity during the midlife period. Most interestingly, the level of glial fibrillary acidic protein also changes similarly to the previously named markers. Our results provide further evidence that protein content is modified at least in some cell populations of the rat retina, and the number of retinal cells declined with aging. We conclude that senescence alone may cause structural and functional damage in the retinal tissue.

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Raja, N. R. Livingston. "Anti-Edema Activity of Sida rhombifolia in Albino Wistar Rats." International Journal of Pharmacy & Biomedical Research 8, no. 2 (April 30, 2021): 12–17. http://dx.doi.org/10.18782/2394-3726.1109.

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35

G, Yadav, Awasthi J R, Pandey N, Shrestha S, and Jha CB. "EFFECT OF VITAMIN E AGAINST HEAT STRESS INDUCED TESTICULAR DAMAGE IN WISTAR ALBINO RATS." International Journal of Anatomy and Research 5, no. 2.2 (May 31, 2017): 3800–3804. http://dx.doi.org/10.16965/ijar.2017.184.

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Putri, Tetra Anestasia. "PENGARUH PEMBERIAN BISPENOL-A (BPA) TERHADAP JUMLAH SPERMATOZOA PADA Rattus norvegicus GALUR WISTAR ALBINO." JURNAL KESEHATAN PERINTIS (Perintis's Health Journal) 6, no. 1 (June 28, 2019): 9–13. http://dx.doi.org/10.33653/jkp.v6i1.210.

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Bispenol-a (BPA) has an esterogen hormone activity while it enters the body, it can become endocrine disruptor. The objetive of this study was to purpose to prove that bispenol a can decrease spermatozoa cell count in male wistar albino strain rats (rattus novergicus).This research is an experimental design with post-only control group by using 20 male wistar albino strain rats (rattus Novergicus). Those sample aged 2-3 months which divided into four groups for 5 rats each. Control group (K) without bispenol-a adduction. The first (P1), second (P2), and third (P3) group treatment was given with BPA in 51 days for 0.45, 0.9 and 1.8 mg/body weight(kgs)/day for a 51-day. After 51-day treatment.This research showed that mean value of testosterone hormone for control group was 7.78 ng/lts. P1 group, P2 and P3 groups showed 6.19, 5.23 and 4.02 ng/lt.the count of spermatozoa has mean value for control group was 39,1 while first group (P1) was 30.2 . In second (P2) and third (P3) treatment group were 21,1 and 19.7. Data analysis showed mice spermatozoa cell count had p <0.05, which means that there is significance differentiation between control and treatment groups.It can be concluded that there is an effect of bisphenol a adduction on male Rattus novergicus wistar albino strain spermatozoa cell count.

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De Russi, Brenno Marco, and Camila Albuquerque Melo Carvalho. "Anatomic and Embryological Aspects of the Cardiovascular System of Albino Wistar Rats." Journal of Morphological Sciences 36, no. 04 (September 19, 2019): 317–20. http://dx.doi.org/10.1055/s-0039-1697008.

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AbstractThe Wistar albino rat is the animal most commonly used in scientific research around the world. Knowledge of the anatomy of the body of these animals is key in the research field, especially in cases when the research requires experimental surgery. Descriptive literature on the morphology of the cardiovascular system of these animals, particularly the heart, is old and difficult to access. Publications in journals are not readily available, and books approach the subject in a superficial way. The aim of this study is to research, organize, and translate the literature on the anatomy and embryology of the cardiovascular system of the albino Wistar rat to facilitate the use of this information in future research that requires the knowledge of the anatomy of these animals, for example, experimental surgery research.

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CHUKWUNELO, Alpha C., Assumpta C. ANOSIKE, Emmanuel I. NNAMONU, Daniel E. EKPO, Prince O. JAMES, and Tochukwu I. OKONKWO. "Evaluation of Leukocyte Mobilization and Platelet Aggregatory Effects of Ciprofloxacin, Lincomycin and Erythromycin in Wistar Albino Rats." Notulae Scientia Biologicae 11, no. 4 (December 24, 2019): 345–51. http://dx.doi.org/10.15835/nsb11410491.

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This study evaluated leucocyte mobilization and platelet aggregation effects of ciprofloxacin, lincomycin and Erythromycin in Wistar albino rats. Thirty-three female Wistar albino rats weighing 130-160 g and three male Wistar albino rats weighing 188-194 g, fed commercial growers’ mash and clean tap water were used. In leukocytes assay, thirty-three adult female Wistar rats were assigned into five treatments, eleven groups of three rats per group. First three groups were treated 10 mg kg-1, 20 mg kg-1 and 40 mg kg-1 of ciprofloxacin, next three groups same doses of lincomycin, next three groups same doses of Erythromycin, the tenth group received Indomethacin 5 mg kg-1 (reference drug), the last group 5 mg kg-1 normal saline. Assay on platelet aggregator activity involved collection of blood samples (10 ml each, 1% EDTA, centrifuged at 3000 rpm for 10 minutes), test drugs dissolved in 1 mg/ml distilled water and Indomethacin (the reference drug). The three antibiotics significantly reduced leucocyte mobilization into the affected tissue. They all had their maximum inhibitory effects at the highest dose (40 mg kg-1) compared with indomethacin. Erythromycin 40 mg kg-1 showed the highest inhibitory effect on leucocyte migration. Whereas ciprofloxacin and erythromycin had stepwise increase in absorbance from time 0 secs through to time 120 secs, lincomycin showed a sharp decrease in the absorbance at around 30 seconds followed by a continuous increase up to 120 seconds. The testing drugs prevented leukocyte mobilization also had stepwise increase in absorbance from time 0 secs through to time 120 secs in platelet aggregatory activity assay to some extent.

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Augustine, Clement, Dishi Khobe, Altine J. Madugu, Yahaya Babakiri, Isa Joel, Tiva John, Joseph U. Igwebuike, and Asabe Ibrahim. "Productive performance and cost benefits of feeding wistar albino rats with processed tropical sickle pod (Senna obtusifolia) leaf meal-based diets." Translational Animal Science 4, no. 2 (April 1, 2020): 589–93. http://dx.doi.org/10.1093/tas/txaa036.

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Abstract A feeding trial was conducted for 28 d to evaluate the effects of feeding albino rats with processed Senna obtusifolia leaf meal (SOLM) based diets. Five experimental diets were compounded to contain 0% and 20% each of the sun-dried, boiled, fresh fermented, boiled fermented SOLM-based diets designated as T1, T2, T3, T4, and T5, respectively. A total of 90 young albino rats with initial weight of 13.52–14.48 g were randomly allocated to the dietary treatments in a completely randomized design with three replicates of six rats each. The result of the productive performance was not significantly (P > 0.05) different, except feed intake, which indicated significant (P < 0.05) variation. The highest total feed intake (365.40 g) was recorded in albino rats fed the control diet (0% SOLM) and 20% boiled and fermented SOLM (334.32 g). The overall weight gain among the albino rats fed the processed SOLM-based diets were not significantly (P > 0.05) different. Results on cost benefits revealed a reduction in feed cost per kilogram, cost of feed intake, and feed cost per kilogram body weight gain recorded in SOLM-based diets (T2–T5). Feed cost per kilogram was observed to reduce by 21.86, 20.79, 21.80, and 18.79 in T2–T5, respectively. It was concluded that the processed SOLM-based diets had enhanced the productive performance of albino rats. However, albino rats fed the boiled and fermented SOLM-based diet indicated better feed intake compared with the other groups of rats fed the other processed SOLM-based diets. On economic grounds, the use of processed SOLM as a feed ingredient for albino rats is cost effective because of the reduction in feed cost per kilogram of the SOLM-based diets and feed cost per kilogram body weight gain observed in albino rats fed SOLM-based diets and is, therefore, recommended for feeding albino rats.

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Singh, Rajbala, Ruqaiyah Khan, Deepak Tiwari, Heman Heman, Rajbir Singh, and Firoz Anwar. "Pharmacological and biochemical assessment of Talc on Doxorubicin induced cardiac remodelling in albino Wistar rats." Asian Pacific Journal of Health Sciences 3, no. 1 (January 2016): 44–52. http://dx.doi.org/10.21276/apjhs.2016.3.1.8.

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Sibi, P. Ittiyavirah, and K. P. Sajid. "Behavioural assessment of Mikania micrantha Kunth roots in Wistar albino rats." Journal of Medicinal Plants Research 8, no. 11 (March 17, 2014): 448–53. http://dx.doi.org/10.5897/jmpr2013.5334.

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Ittiyavirah, SibiPerumbamkudiyil, and Ibrahim Pullochal. "Adaptogenic and nootropic activity of Mimosa pudica in albino wistar rats." International Journal of Nutrition, Pharmacology, Neurological Diseases 4, no. 4 (2014): 231. http://dx.doi.org/10.4103/2231-0738.139404.

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Adomi, PO, UB Owhe-Ureghe, and SO Asagba. "EVALUATION OF THE TOXICITY OF PHYLLANTHUS AMARUS IN WISTAR ALBINO RATS." African Journal of Cellular Pathology 8, no. 5 (May 31, 2017): 27–35. http://dx.doi.org/10.5897/ajcpath17.005.

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Lodhi, Lal. "Evaluation of mechanism of hepatotoxicity of leflunomide using albino wistar rats." African Journal of Pharmacy and Pharmacology 7, no. 24 (June 29, 2013): 1625–31. http://dx.doi.org/10.5897/ajpp2013.3517.

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Abiodun, Humphrey Adebayo, Samuel Adegbite Oluwatobi, A. O. Olugbuyiro Joseph, Olorunfunmi Famodu Oyetomiwa, and Bernard Odenigbo Kenechukwu. "Toxicological evaluation of extract of Olax subsorpioidea on albino Wistar rats." African Journal of Pharmacy and Pharmacology 8, no. 21 (June 8, 2014): 570–78. http://dx.doi.org/10.5897/ajpp2013.3900.

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SONBAY YILMAZ, Nevreste Didem, Cem SAKA, Sibel ALİCURA TOKGÖZ, Murat ÇALIŞKAN, Erkan VURALKAN, and Ömer BEŞALTI. "Effects of acute hypoxia on auditory pathway of Wistar albino rats." TURKISH JOURNAL OF MEDICAL SCIENCES 50, no. 6 (October 22, 2020): 1580–84. http://dx.doi.org/10.3906/sag-1911-166.

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Background/aim: Ischemia is insufficient blood flow to provide adequate oxygenation. In the present study, we aimed to show whether acute hypoxia has a critical oxygen value that may lead to the deterioration of cochlear function.Materials and methods: Under general anesthesia, prehypoxic signal-to-noise ratios were determined by distortion product otoacoustic emissions (DPOAE). The oxygen saturation (SaO2) values of rats were monitored with an oxygen saturation probe. Rats were injected with an extra dose of anesthetic agent, and SaO2 was reduced. DPOAE values in SaO2 100–90, 90–80, 80–70, and 70–60 posthypoxic values were measured and compared statistically with prehypoxic values.Results: At 3000 and 4000 Hz, SaO2 70–60 values measured after the hypoxia were observed to be statistically significantly lower than the values measured before the hypoxia. At 6000 and 8000 Hz, SaO2 80–70 and 70–60 values measured after the hypoxia were observed to be statistically significantly lower than the values measured before the hypoxia. At 10,000 Hz, all of the values measured after the hypoxia were observed to be statistically significantly lower than the values obtained before the hypoxia.Conclusion: Many studies have been conducted on the effects of hypoxia on the inner ear. It remains unclear how fluctuations in DPOAE levels affect hearing in clinical trials when the SaO2 starts to decrease. Although hypoxia has been implicated in the etiology of sudden hearing loss and tinnitus, the effects of acute hypoxia on the cochlea are still uncertain. Further studies are needed on this subject.

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Ghori, Syed Safiullah, Mohammed Idrees Hussain, Fouzia Tehseen, Sheema Mustafa, and Abdul Samad. "Evaluation of Analgesic Activity of Polyherbal Formulation in Albino Wistar Rats." Research Journal of Pharmacy and Technology 13, no. 5 (2020): 2287. http://dx.doi.org/10.5958/0974-360x.2020.00412.6.

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A. Omer, Sawsan, M. A. Elobeid, M. H. Elamin, Z. K. Hassan, P. Virk, M. H. Daghestani, E. M. Al-Olayan, Nadia A. Al-Eisa, and Z. M. Almarhoon. "Toxicity of Olive Leaves (Olea europaea L.) In Wistar Albino Rats." Asian Journal of Animal and Veterinary Advances 7, no. 11 (October 15, 2012): 1175–82. http://dx.doi.org/10.3923/ajava.2012.1175.1182.

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Mohan, Mahalaxmi, Mohammed Saad, Santosh Tambe, Shishir Pande, Abhay Kulkarni, Sunil Bakare, and Aniruddha Mohite. "PRE-CLINICAL TOXICITY STUDY OF TAMRA BHASMA ON ALBINO WISTAR RATS." International Research Journal of Pharmacy 9, no. 1 (February 19, 2018): 36–46. http://dx.doi.org/10.7897/2230-8407.0916.

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Gradošová, Iveta, Helena Živná, Klára Švejkovská, Vladimír Palička, Aleš Tichý, and Pavel Živný. "Effects of amlodipine on bone metabolism in male albino Wistar rats." Acta Veterinaria Brno 80, no. 4 (2011): 391–96. http://dx.doi.org/10.2754/avb201180040391.

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Amlodipine (dihydropyridine-type calcium channel blocker) is a widely used agent for the treatment of hypertension in human and veterinary medicine but detailed information about its effects on bone metabolism are missing. Therefore, the aim of our study was to investigate the effect of amlodipine on bone metabolism in male albino Wistar rats. Amlodipine (0.3 mg/100 g body weight; gavage) was administered to 8 rats for 8 weeks. Control group (n = 8) received aqua pro inj. (0.2 ml/100 g body weight; gavage). Bone marker concentrations of carboxy-terminal cross-linking telopeptide of type I collagen (CTX-I) and aminoterminal propeptide of procollagen type I in serum, and of bone alkaline phosphatase (BALP) in both serum and bone homogenate were measured by enzyme immunoassay. We investigated the expression of bone morphogenetic protein 2 (BMP-2) in proximal tibia using Western blotting, and bone mineral density was measured by Dual-energy X-ray Absorptiometry in lumbar and caudal vertebrae and in femoral areas. Mechanical properties of the femurs were measured by three-point bending of the shaft and compression testing of the femoral neck. After 8 weeks of amlodipine administration there was a significant decrease in serum concentrations of BALP (p = 0.0009) and CTX-I (p = 0.003), and the content of BALP in bone homogenate (p = 0.026) compared to the control. In addition, Western blot analysis indicated increased BMP-2 protein concentration after amlodipine administration. Our findings suggest that amlodipine has a retarding influence on bone metabolism in rats by decreasing bone turnover, which probably in consequence increases expression of BMP-2.

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