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Journal articles on the topic 'Withania somnifera – Therapeutic use'

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Published: 4 June 2021

Last updated: 12 February 2022

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1

Alam, Md Khorshed, Md Obydul Hoq, and Md Shahab Uddin. "Therapeutic use of Withania somnifera." Asian Journal of Medical and Biological Research 2, no. 2 (2016): 148–55. http://dx.doi.org/10.3329/ajmbr.v2i2.29004.

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Withania somnifera (L) Dunal is commonly called as Ashwagandha/Asgand and it belongs to the family Solanaceae. It is a well known medicinal plant widely used in the treatment of many clinical conditions in Indian subcontinent. It is an important medicinal plant commonly known as Asgand which has been used either single or in combination with other drugs in Unani as well as Ayurvedic system of medicine for centuries. It has been described by Dioscorides (78 AD) in his book Kitab-ul-Hashaish. Asgand consists of the roots of Withania somnifera which has various therapeutic actions such as anti

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Nimbalwar, Minakshee G. "Pharmacognostic and Nootropic Aspects of Withania Somnifera: A Potential Herbal Drug as Memory Enhancer." International Journal for Research in Applied Science and Engineering Technology 9, no. 8 (2021): 1075–81. http://dx.doi.org/10.22214/ijraset.2021.37402.

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Abstract: Withania somnifera is a well-known herbal drug commonly used in India and Indian subcontinent. It contains a spectrum of diverse phytoconstituents that are responsible for number of significant biological effects. Various parts of plants especially roots are rich in source of active phytoconstituents. In the current COVID-19 situation, various national and international agencies are suggesting the use of plant for increasing immunity as well as memory booster. The drug is mainly used in the management of brain related disorders such as anxiety, depression, stress, etc. The mainly use

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Melo, Adriana de, André Luiz de Melo, Maria Cristina Marcucci, Claudemir de Carvalho, and Carolina Passarelli Gonçalves. "Immunomodulatory activity in tumor-bearing mice treated with Withania somnifera extract." Journal of Analytical & Pharmaceutical Research 10, no. 2 (2021): 82–91. http://dx.doi.org/10.15406/japlr.2021.10.00369.

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We investigated some actions of Withania somnifera on the growth and differentiation of hematopoietic precursors [granulocyte/macrophage colony cell formation (CFU-GM)] of normal animals and EAT bearers, which were treated with different doses (20, 50, or 100 mg/kg/day). We also evaluated the presence of colony stimulatory factors in the animal's serum, as well as its survival. Furthermore, we analyzed lymphocyte proliferation, IFN-ɤ, and TNF-α concentrations in treated bearing mice. Our results demonstrated Withania somnifera effectiveness on hematopoietic precursors growth and differentiatio

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Bungau, Simona, Cosmin Mihai Vesa, Areha Abid, et al. "Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases." Molecules 26, no. 9 (2021): 2407. http://dx.doi.org/10.3390/molecules26092407.

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Withaferin A (WFA) was identified as the most active phytocompound of the plant Withania somnifera (WS) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity—numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficien

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Raveendran, Amrita, Sangeeta Rao, and Vikram S. "Pharmaceutico analytical study of Ashwagandha Ghrita." Journal of Ayurveda and Integrated Medical Sciences (JAIMS) 5, no. 05 (2020): 220–32. http://dx.doi.org/10.21760/jaims.5.5.31.

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Ashwagandha (Withania somnifera (L) Family - Solanaceae) known as Indian ginseng is an effective immunomodulator, aphrodisiac, sedative and adaptogen. Ashwagandha Ghrita is a ghee based Ayurvedic formulation which is available in the market, but Ashwagandha Ghrita containing Rasasindura and Tamra Bhasma along with Ashwagandha and Musta Churna is also mentioned in classical text which many of us are not aware of. As we all know that the action of Rasaushadhis are quick and require very less dose the one mentioned by Vagbhatacharya (author of Rasaratnasamuchaya) is the need of the hour for the i

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Sangiovanni, Enrico, Paola Brivio, Mario Dell’Agli, and Francesca Calabrese. "Botanicals as Modulators of Neuroplasticity: Focus on BDNF." Neural Plasticity 2017 (2017): 1–19. http://dx.doi.org/10.1155/2017/5965371.

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The involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored. The present review considers the literature on the effects of botanicals on BDNF. Botanicals considered wereBacopa monnieri(L.) Pennell,Coffea arabicaL.,Crocus sativusL.,Eleutherococcus senticosusMaxim.,Camellia sinensis(L.) Kuntze (green tea),Ginkgo bilobaL.,Hypericum p

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Farooqui, Akhlaq A., Tahira Farooqui, Anil Madan, Jolin Hwee-Jing Ong, and Wei-Yi Ong. "Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/2481076.

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Ayurvedic medicine is a personalized system of traditional medicine native to India and the Indian subcontinent. It is based on a holistic view of treatment which promotes and supports equilibrium in different aspects of human life: the body, mind, and soul. Popular Ayurvedic medicinal plants and formulations that are used to slow down brain aging and enhance memory include Ashwagandha (Withania somnifera), Turmeric (Curcuma longa), Brahmi (Bacopa monnieri), Shankhpushpi (Convolvulus pluricaulis, Evolvulus alsinoides, and other species), gotu kola (Centella asiatica), and guggulu (Commiphora m

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Ashour, Osama M., Ashraf B. Abdel-Naim, Hossam M. Abdallah, Ayman A. Nagy, Ahmed M. Mohamadin, and Essam A. Abdel-Sattar. "Evaluation of the Potential Cardioprotective Activity of Some Saudi Plants against Doxorubicin Toxicity." Zeitschrift für Naturforschung C 67, no. 5-6 (2012): 297–307. http://dx.doi.org/10.1515/znc-2012-5-609.

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Doxorubicin (DOX) is an anthracycline antibiotic widely used as a chemotherapeutic agent in the treatment of several tumours. However, its cardiac toxicity limits its use at maximum therapeutic doses. Most studies implicated increased oxidative stress as the major determinant of DOX cardiotoxicity. The local Saudi flora is very rich in a variety of plants of quite known folkloric or traditional medicinal uses. Tribulus macropterus Boiss., Olea europaea L. subsp. africana (Mill.) P. S. Green, Tamarix aphylla (L.) H. Karst., Cynomorium coccineum L., Cordia myxa L., Calligonum comosum L’ Hér, and

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Rodríguez Coipel, Yudit, Aníbal Domínguez Odio, Odaimis Mena Álvarez, Raiselys Toirac Proenza, Isbel González Marrero, and Daniel Leonardo Cala Delgado. "De acordo com o governador, a decisão vale para todos que estejam em condições físicas adequadas, mesmo os que ainda não tomaram a vacina contra a Covid-19." Brazilian Journal of Veterinary Research and Animal Science 58 (July 14, 2021): e181002. http://dx.doi.org/10.11606/issn.1678-4456.bjvras.2021.181002.

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The industrial manufacturing of natural products for veterinary use represents a major weakness in the veterinary sector despite increased interest and the traditional ancestral knowledge that supports them. A cross-sectional, descriptive observational study was conducted to characterize the veterinary herbal products marketed worldwide during 2018 and 2019. A comprehensive thematic search limited to the 2018-2019 period was performed in the ScienceDirect, Scopus, PubMed, Web of Science, ResearchGate, and Academic Search Complete databases. The investigation identified 487 products registered

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Choudhary, Sunayna, Indu Pal Kaur, and Jai Malik. "Development and Validation of a Novel, Rapid Gradient HPLC Method for Simultaneous Estimation of Bioactive Marker Compounds in a Mixture of Convolvulus pluricaulis, Withania somnifera and Bacopa monnieri Extracts." Journal of Chromatographic Science 57, no. 10 (2019): 920–30. http://dx.doi.org/10.1093/chromsci/bmz075.

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Abstract The use of herbs as medicine is an ancient form of healthcare known to mankind. Standardization of herbal medicines is however a challenging task and is the major bottleneck in their acceptance as the primary therapeutic option. The aim of this study was to develop and validate a simple, rapid HPLC method for standardizing the mixture of extracts of three Medhya Rasayanas (neurotonic), Convolvulus pluricaulis, Withania somnifera and Bacopa monnieri. Simultaneous estimation of the respective bioactive markers of these plants viz., scopoletin, withaferin A, bacoside A 3, bacopaside II,

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Brunetti, Pietro, Alfredo Fabrizio Lo Faro, Anastasio Tini, Francesco Paolo Busardò, and Jeremy Carlier. "Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects." Pharmaceuticals 13, no. 10 (2020): 309. http://dx.doi.org/10.3390/ph13100309.

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Sexual enhancers increase sexual potency, sexual pleasure, or libido. Substances increasing libido alter the concentrations of specific neurotransmitters or sex hormones in the central nervous system. Interestingly, the same pathways are involved in the mechanisms underlying many psychiatric and neurological disorders, and adverse reactions associated with the use of aphrodisiacs are strongly expected. However, sexual enhancers of plant origin have gained popularity over recent years, as natural substances are often regarded as a safer alternative to modern medications and are easily acquired

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Srivastava, Amit K., Arif Naseer, and Amresh Gupta. "Evaluation of Neurobehavioral and Biochemical Parameters of Poly- Herbal Formulation on MPTP-Intoxicated Mice for the Treatment of PD." Current Bioactive Compounds 16, no. 9 (2020): 1290–98. http://dx.doi.org/10.2174/1573407215666191022114956.

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Background: Formulations containing two or more than two herbs are called polyherbal formulation. Single herb formulation has been well established due to its active phytoconstituents, which are usually present in minute amount and sometimes these are insufficient to achieve the desired therapeutic effects. The popularity of polyherbal formulation is due to its high effectiveness in a vast number of diseases. Methods: In this study, poly-herbal formulations were prepared by using different solvent extracts with the help of the hot extraction process through Soxhlet apparatus. The poly-herbal f

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Narra, Haribabu. "Tissue Culture Studies in Withania Somnifera (L.) Dunal." Plantae Scientia 3, no. 6 (2020): 95–98. http://dx.doi.org/10.32439/ps.v3i6.95-98.

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Withania somnifera is an important medicinal herb that has been widely used for the treatment of different clinical conditions. The overall medicinal properties of Withania somnifera make it a viable therapeutic agent for addressing anxiety, cancer, microbial infection, immunomodulation, and neurodegenerative disorders. Biochemical constituents of Withania somnifera like withanolide A, withanolide D, withaferin A and withaniamides play an important role in its pharmacological properties. Proteins like Withania somnifera glycoprotein and withania lectin like-protein possess potent therapeutic p

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Tounekti, Taieb, Mosbah Mahdhi, and Habib Khemira. "Ethnobotanical Study of Indigenous Medicinal Plants of Jazan Region, Saudi Arabia." Evidence-Based Complementary and Alternative Medicine 2019 (June 2, 2019): 1–45. http://dx.doi.org/10.1155/2019/3190670.

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For a long time, the people of Saudi Arabia have been using medicinal plants (MPs) as conventional medicine to heal diverse human and livestock diseases. The present work is the first study on ethnobotanical uses of 124 MPs species used by the local tribal communities of Jazan province in the Southwest of Saudi Arabia. Ethnobotanical data were collected by interviewing 174 local informants using semistructured interviews. Informants of different ages, from several settlements belonging to several tribal communities, were interviewed. It is worth noticing that the age of informants and their kn

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Padhye, Mugdha Rajeeva, Sangita Devrao Jogdand, and Jagruti Bhattacharjee. "Evaluation and comparison of nephroprotective effect of Hemidesmus indicus Linn. and Withania somnifera Linn. on gentamicin induced nephrotoxicity in Albino rats." International Journal of Basic & Clinical Pharmacology 7, no. 4 (2018): 691. http://dx.doi.org/10.18203/2319-2003.ijbcp20181171.

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Background: Nephrotoxicity is a known deleterious effect of Aminoglycoside antibiotics. This class of antibiotics is used very frequently. It is well known that Gentamicin causes renal tubular necrosis in the proximal tubular cells. Phytochemicals are being studied extensively and have proved to be of benefit in various diseases. The use of phytochemicals would minimize the adverse effects encountered with these antibiotics. Comparison between various phytochemicals would help in optimizing dosage and duration of treatment. In the present study we studied and compared the nephroprotective effe

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Saggam, Akash, Girish Tillu, Santosh Dixit, et al. "Withania somnifera (L.) Dunal: A potential therapeutic adjuvant in cancer." Journal of Ethnopharmacology 255 (June 2020): 112759. http://dx.doi.org/10.1016/j.jep.2020.112759.

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Sukumar, Bargale Sushant, Tripathy T. B., and Shashirekha H.K. "Phyto physico-chemical profile of Ashwagandha (Withania somnifera Dunal)." Journal of Ayurveda and Integrated Medical Sciences (JAIMS) 5, no. 06 (2020): 120–29. http://dx.doi.org/10.21760/jaims.5.6.17.

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Introduction: The present article deals with study of phytochemical analysis of Withania somnifera Dunal roots. Ashwagandha (Withania somnifera Dunal - Solanaceae), The use of Ashwagandha (WS) is increasing due to a number of chemical constituents present in are found useful for promotion of health. Important bio-active constituents of Ashwagandha root powder are alkaloids, tannins and flavonoid and phenolic compound helps to promote the health benefits. Objective: Evolution of Physico- chemical and phyto chemical analysis of Ashwagandha (WS) powder. Materials and methods: The current investig

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Anju, T. R., S. Smijin, M. Jobin, and C. S. Paulose. "Altered muscarinic receptor expression in the cerebral cortex of epileptic rats: restorative role of Withania somnifera." Biochemistry and Cell Biology 96, no. 4 (2018): 433–40. http://dx.doi.org/10.1139/bcb-2017-0198.

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Temporal lobe epilepsy involves a sequence of events that can lead to neurotransmitter signalling alterations. There are many herbal extracts considered to be alternative therapeutic methods to manage epilepsy. In this study, we investigated the effect of Withania somnifera (WS) root extract and withanolide A (WA) in the management of temporal lobe epilepsy. Confocal imaging of TOPRO-3-stained cortical sections showed severe damage in the epileptic brain. We also observed a reduced antioxidant potential and increased peroxide levels in the epileptic test group of rats. Oxidative stress resulte

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Ruhela, Rakesh, Shringika Soni, and Bikash Medhi. "Therapeutic Potential of Withania somnifera in CNS Disorders: A Neuropharmacological Review." European Journal of Medicinal Plants 16, no. 2 (2016): 1–12. http://dx.doi.org/10.9734/ejmp/2016/24187.

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Singh, Neha, and Dr Anita R. J. Singh. "Biochemical and Therapeutic Properties of Withania Somnifera in Traditional Medicinal System." International Journal of Trend in Scientific Research and Development Volume-3, Issue-3 (2019): 551–56. http://dx.doi.org/10.31142/ijtsrd21715.

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Minhas, Ujla, Ranjana Minz, Prabir Das, and Archana Bhatnagar. "Therapeutic effect of Withania somnifera on pristane-induced model of SLE." Inflammopharmacology 20, no. 4 (2011): 195–205. http://dx.doi.org/10.1007/s10787-011-0102-8.

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Kaur, Prabhjot, and Anupam Tiwari. "Use of Abiotic Elicitors to enhance Secondary Metabolites Production in Withania somnifera." Research Journal of Pharmacy and Technology 11, no. 11 (2018): 5139. http://dx.doi.org/10.5958/0974-360x.2018.00938.1.

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Balkrishna, Acharya, Pradeep Nain, Anshul Chauhan та ін. "Super Critical Fluid Extracted Fatty Acids from Withania somnifera Seeds Repair Psoriasis-Like Skin Lesions and Attenuate Pro-Inflammatory Cytokines (TNF-α and IL-6) Release". Biomolecules 10, № 2 (2020): 185. http://dx.doi.org/10.3390/biom10020185.

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(1) Background: Withania somnifera Dunal (Ashwagandha) is a widely used medicinal herb in traditional medicinal systems with extensive research on various plant parts. Surprisingly, seeds of W. somnifera have never been investigated for their therapeutic potential. (2) Methods: W. somnifera seeds were extracted for fatty acids (WSSO) using super critical fluid extraction, and was analyzed by gas chromatography. Its therapeutic potential in psoriasis-like skin etiologies was investigated using a 12-O tetradecanoyl phorbol 13-acetate (TPA)-induced psoriatic mouse model. Psoriatic inflammation al

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Santhanu, Krishnapriya, and Kalaiselvi Senthil. "Therapeutic potential of Withania somnifera (Linn) Dunal (Ashwagandha) in historical perspective and pharmacological evidence." Annals of Ayurvedic Medicine 10, no. 2 (2021): 135. http://dx.doi.org/10.5455/aam.122229.

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Kumar, Satyanshu, Raghuraj Singh, Narendra Gajbhiye, and Tushar Dhanani. "Extraction Optimization for Phenolic- and Withanolide-Rich Fractions from Withania somnifera Roots: Identification and Quantification of Withaferin A, 12-Deoxywithastromonolide, and Withanolide A in Plant Materials and Marketed Formulations Using a Reversed-Phase HPLC–Photodiode Array Detection Method." Journal of AOAC INTERNATIONAL 101, no. 6 (2018): 1773–80. http://dx.doi.org/10.5740/jaoacint.18-0081.

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Abstract Background: Both the roots and leaves of Withania somnifera are products of commerce. They contain active compounds of therapeutic value and mostly different withanolides. Several pharmacological activities of W. somnifera have links to one or more withanolides. The presence of phenolic compounds in extracts could play a vital role in the reduction of blood glucose levels in diabetic subjects. Objective: The present study was carried out for the selection of a solvent to prepare extracts rich in phenolics, withaferin A (WA), 12-deoxywithastromonolide (12WD), and withanolide A (WDA). A

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C.Thilip, P. Raja, K.Mohamed Rafi, et al. "Genetic Transformation using Agrobacterium rhizogenes for the Production of Valuable Anti-Cancer Compound, Withaferin-A from Withania somnifera (L.) Dunal." Jamal Academic Research Journal : An Interdisciplinary 1, no. 1 (2020): 1–5. http://dx.doi.org/10.46947/jarj1120201.

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Withania somnifera (L.) Dunal is an important ayurvedic medicinal plant and its primary bioactive compound, withaferin-A possess several pharmaceutical and therapeutic values ranging from immunomodulation to anti-cancer property. For commercial production of withaferin-A, field grown plant materials have generally been used but the quality and uniformity in the levels of active constituents are highly affected by genotype and environmental conditions. Plant tissue culture methods are best alternative way to enhance commercial production of withaferin-A. In this present study, we summarize our

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Sarin, Rajat, and Sachin Sharma. "Exploration of Therapeutic Efficacy of Withania somnifera and Curcuma longa In Alzheimer’s disease - A Boon." Indo Global Journal of Pharmaceutical Sciences 09, no. 02 (2019): 144. http://dx.doi.org/10.35652/igjps.2019.92s42.

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Tripathi, Niraj, Divya Shrivastava, Bilal Ahmad Mir, et al. "Metabolomic and biotechnological approaches to determine therapeutic potential of Withania somnifera (L.) Dunal: A review." Phytomedicine 50 (November 2018): 127–36. http://dx.doi.org/10.1016/j.phymed.2017.08.020.

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Tiwari, Ruchi, Sandip Chakrabort, Mani Saminathan, Kuldeep Dhama, and Shoor Vir Singh. "Ashwagandha (Withania somnifera): Role in Safeguarding Health, Immunomodulatory Effects, Combating Infections and Therapeutic Applications: A Review." Journal of Biological Sciences 14, no. 2 (2014): 77–94. http://dx.doi.org/10.3923/jbs.2014.77.94.

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De, Manojit, and Suman Bhusan Chakraborty. "Use of Withania somnifera root powder for production of monosex Nile tilapia, Oreochromis niloticus." IOSR Journal of Pharmacy and Biological Sciences 11, no. 05 (2016): 28–31. http://dx.doi.org/10.9790/3008-1105022831.

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Ambiye, Vijay R., Deepak Langade, Swati Dongre, Pradnya Aptikar, Madhura Kulkarni, and Atul Dongre. "Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/571420.

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Ashwagandha (Withania somnifera) has been described in traditional Indian Ayurvedic medicine as an aphrodisiac that can be used to treat male sexual dysfunction and infertility. This pilot study was conducted to evaluate the spermatogenic activity of Ashwagandha root extract in oligospermic patients. Forty-six male patients with oligospermia (sperm count < 20 million/mL semen) were enrolled and randomized either to treatment (n=21) with a full-spectrum root extract of Ashwagandha (675 mg/d in three doses for 90 days) or to placebo (n=25) in the same protocol. Semen parameters and serum horm

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Gaurav, Isha, Tanuja Singh, Abhimanyu Thakur, et al. "Synthesis, In-Vitro and In-Silico Evaluation of Silver Nanoparticles with Root Extract of Withania somnifera for Antibacterial Activity via Binding of Penicillin-Binding Protein-4." Current Pharmaceutical Biotechnology 21, no. 15 (2020): 1674–87. http://dx.doi.org/10.2174/1389201021666200702152000.

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Background: Metal Nanoparticles (NPs) have been widely used for various applications in biomedical sciences, including in drug delivery, and as therapeutic agents, but limited owing to their toxicity towards the healthy tissue. This warrants an alternative method, which can achieve the desired activity with much reduced or no toxicity. Being a biological product, Withania somnifera (W. somnifera) is environment friendly, besides being less toxic as compared to metal-based NPs. However, the exact mechanism of action of W. somnifera for its antibacterial activities has not been studied so far. O

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Kulkarni, Anjali A., S. M. Kelkar, M. G. Watve, and K. V. Krishnamurthy. "Characterization and control of endophytic bacterial contaminants in in vitro cultures of Piper spp., Taxus baccata subsp. wallichiana, and Withania somnifera." Canadian Journal of Microbiology 53, no. 1 (2007): 63–74. http://dx.doi.org/10.1139/w06-106.

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Bacterial contamination is a serious problem that causes severe loss of in vitro grown cultures of a number of plants. This problem becomes even more acute if the bacterial contamination is of endophytic origin. In such cases, identification and characterization of the contaminants is essential for achieving specific control of the contaminants through selective use of antibiotic agents, especially if the routinely used contamination control methods practiced elsewhere in tissue culture studies are ineffective. Such is the case with the bacterial contamination observed in the present study. Th

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Tapan Behl, Chanchal Kumar, Roshan Kumar Singh, Taruna Katyal Arora, and Sandeep Arora. "Traditional and Novel Herbal Drugs Emerging as Potent Novel Combinations for Managing Morbidities by Pharmacological and Mechanistic Studies." Journal of Pharmaceutical Technology, Research and Management 6, no. 1 (2018): 31–53. http://dx.doi.org/10.15415/jptrm.2018.61004.

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Background: Herbal drugs are used in treatment of diseases since decades. Major contributing factor for their use is easy availability, less expensive and more belief of common population because of relatively less side effects compared to allopathic medicines. Medicines of natural origin or functional foods in the prevention of disease are the need of hour. Hence, the present review focused on activity of four drugs viz. Withania somnifera,Allium sativum,Curcuma longa andAzadirachta indica and role in different clinical complications.Methods: A thorough review of all the articles, research as

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Nasimi Doost Azgomi, Ramin, Afshar Zomorrodi, Hossein Nazemyieh, et al. "Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence." BioMed Research International 2018 (January 24, 2018): 1–17. http://dx.doi.org/10.1155/2018/4076430.

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Introduction. Withania somnifera (WS) also known as ashwagandha is a well-known medicinal plant used in traditional medicine in many countries for infertility treatment. The present study was aimed at systemically reviewing therapeutic effects of WS on the reproductive system. Methods. This systematic review study was designed in 2016. Required data were obtained from PubMed, Scopus, Google Scholar, Cochrane Library, Science Direct, Web of Knowledge, Web of Science, and manual search of articles, grey literature, reference checking, and expert contact. Results. WS was found to improve reproduc

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Ng, Qin Xiang, Wayren Loke, Nadine Xinhui Foo, et al. "A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction." Phytotherapy Research 34, no. 3 (2019): 583–90. http://dx.doi.org/10.1002/ptr.6552.

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EL-Hefny, Mervat, Mohamed Z. M. Salem, Said I. Behiry, and Hayssam M. Ali. "The Potential Antibacterial and Antifungal Activities of Wood Treated with Withania somnifera Fruit Extract, and the Phenolic, Caffeine, and Flavonoid Composition of the Extract According to HPLC." Processes 8, no. 1 (2020): 113. http://dx.doi.org/10.3390/pr8010113.

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In the present study, Melia azedarach wood blocks treated with different acetone extract concentrations from Withania somnifera fruits are assessed for their antibacterial and anti-fungal activities. Wood blocks of M. azedarach treated with W. somnifera fruit extract at concentrations of 0, 1, 2, and 3% are evaluated for in vitro antimicrobial activity against five genbank accessioned bacterial strains—Agrobacterium tumefaciens, Dickeya solani, Erwinia amylovora, Pseudomonas cichorii, and Serratia pylumthica—and two fungi, namely, Fusarium culmorum and Rhizoctonia solani. Through HPLC analysis

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Mundkinajeddu, Deepak, Laxman P. Sawant, Rojison Koshy, et al. "Development and Validation of High Performance Liquid Chromatography Method for Simultaneous Estimation of Flavonoid Glycosides in Withania somnifera Aerial Parts." ISRN Analytical Chemistry 2014 (March 10, 2014): 1–6. http://dx.doi.org/10.1155/2014/351547.

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Withania somnifera (L.) Dunal (Solanaceae) commonly known as ashwagandha, is an important plant in Ayurveda and is believed to increase longevity and vitality. The root is considered to be the medicinally important part of the plant as per classical texts and accordingly is the subject of most Pharmacopeial monographs. The aerial parts, being less expensive, are sometimes mixed with roots to prepare “standardized” extracts of W. somnifera, and in cases with false declaration of plant part used as roots on the certificate of analysis. The present study described a new, simple, accurate, and pre

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Mydeen, Abdul Kapur Mohamed, and Ahmed John Syed Basha. "Studies on potential of Withania somnifera root extract against diabetic foot infection pathogens." Journal of Microbiology and Biotechnology Research 7, no. 5 (2017): 11. http://dx.doi.org/10.24896/jmbr.2017752.

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Withaniasomnifera phytochemical analysis of root extract showed the presence of alkaloids, flavonoids, tannins saponins, carbohydrates, quinines and phenol compounds. Studies on the prevalence of diabetic foot infections showed a total of 88 isolates belongs to seven different genera. The standard antibacterial study reveals that E.coli and S.aureus were only isolated pathogens showed the high degree of resistant pattern against all tested antibiotics. S.aureus showed 100 percent resistant to penicillin, ampicillin and amoxicillin. Out of 40 S.aureus isolates, 23 were found to be methicillin r

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Nadeem Khan, Mohammad. "Elastin Structure Protein Non-Enzymatic Glycation Inhibition Studies by Use of Secondary Metabolites of Withania somnifera." International Journal of Current Research and Academic Review 5, no. 12 (2017): 25–39. http://dx.doi.org/10.20546/ijcrar.2017.512.005.

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Behl, Tapan, Aditi Sharma, Lalit Sharma, et al. "Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives." Biomedicines 8, no. 12 (2020): 571. http://dx.doi.org/10.3390/biomedicines8120571.

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Withaferin A (WA), a manifold studied, C28-steroidal lactone withanolide found in Withania somnifera. Given its unique beneficial effects, it has gathered attention in the era of modern science. Cancer, being considered a “hopeless case and the leading cause of death worldwide, and the available conventional therapies have many lacunae in the form of side effects. The poly pharmaceutical natural compound, WA treatment, displayed attenuation of various cancer hallmarks by altering oxidative stress, promoting apoptosis, and autophagy, inhibiting cell proliferation, reducing angiogenesis, and met

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Ahmed A. Aljamali, Ahmed A. Aljamali. "Study the Effect of Water Extracts of Some Plants Against Fungus Macrophomina Phaseolina That Causes Charcoal Rot on Common Beans." journal of King Abdulaziz University - Meteorology, Environment and Arid Land Agriculture Sciences 27, no. 2 (2018): 75–88. http://dx.doi.org/10.4197/met.27-2.8.

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The objective of this study was to study the effect of water extracts of plants from the local environment on the growth of fungus Macrophomina Phaseolina. Laboratory results showed a positive effect of water extracts in inhibiting the growth of pathogenic fungus where the percentage of inhibition of extracts (Alknah) Kanahia laniflora, Oleander Nerium, Eucalyptus camaldulensis, (Alsniffh) Argemone mexicana, (Alabb) Withania somnifera, (Alothurb) Rumex nervosus, respectively, 64.07%, 42.96%, 42.58%, 41.86%, 33.48%, and 22.96%. As for the greenhouse experiments results showed an increase in ger

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Cheah, Kae Ling, Mohd Noor Norhayati, Lili Husniati Yaacob, and Razlina Abdul Rahman. "Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis." PLOS ONE 16, no. 9 (2021): e0257843. http://dx.doi.org/10.1371/journal.pone.0257843.

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Objective To determine the effect of Ashwagandha extract on sleep. Methods A comprehensive search was conducted in CENTRAL, MEDLINE, SCOPUS, Google Scholars, World Health Organization Trials Portal, ClinicalTrials.gov, Clinical Trial Registry of India, and AYUSH Research Portal for all appropriate trials. Randomized controlled trials that examined the effect of Ashwagandha extract versus placebo on sleep in human participants 18 years old and above were considered. Two authors independently read all trials and independently extracted all relevant data. The primary outcomes were sleep quantity

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Hybertson, Brooks M., Bifeng Gao, Swapan Bose, and Joe M. McCord. "Phytochemical Combination PB125 Activates the Nrf2 Pathway and Induces Cellular Protection against Oxidative Injury." Antioxidants 8, no. 5 (2019): 119. http://dx.doi.org/10.3390/antiox8050119.

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Bioactive phytochemicals in Rosmarinus officinalis, Withania somnifera, and Sophora japonica have a long history of human use to promote health. In this study we examined the cellular effects of a combination of extracts from these plant sources based on specified levels of their carnosol/carnosic acid, withaferin A, and luteolin levels, respectively. Individually, these bioactive compounds have previously been shown to activate the nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor, which binds to the antioxidant response element (ARE) and regulates the expression of a wi

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Shirin, Khaula, Saima Imad, Sheraz Shafiq, and Kaneez Fatima. "Determination of major and trace elements in the indigenous medicinal plant Withania somnifera and their possible correlation with therapeutic activity." Journal of Saudi Chemical Society 14, no. 1 (2010): 97–100. http://dx.doi.org/10.1016/j.jscs.2009.12.015.

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Mishra, Bhawana, Subir K. Bose, and Neelam S. Sangwan. "Comparative investigation of therapeutic plant Withania somnifera for yield, productivity, withanolide content, and expression of pathway genes during contrasting seasons." Industrial Crops and Products 154 (October 2020): 112508. http://dx.doi.org/10.1016/j.indcrop.2020.112508.

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GUPTA, Manjul, Pankaj Kumar SRIVASTAVA, SHIKHA, Abhishek NIRANJAN, and Shri Krishna TEWARI. "Use of a Bioaugmented Organic Soil Amendment in Combination with Gypsum for Withania somnifera Growth on Sodic Soil." Pedosphere 26, no. 3 (2016): 299–309. http://dx.doi.org/10.1016/s1002-0160(15)60044-3.

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Khan, Mahmood Ahmad, Mythily Subramaneyaan, Vinod Kumar Arora, and Rafat Sultana Ahmed. "Suppression of inflammation and cartilage destruction by steroid-rich methanolic extract of Withania Somnifera: A study on collagen induced arthritic rats." Journal of Experimental and Applied Animal Sciences 2, no. 2 (2017): 172. http://dx.doi.org/10.20454/jeaas.2017.1281.

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Rheumatoid arthritis (RA) is an inflammatory disorder characterized by oxidative stress, inflammation and cartilage destruction. Withania somnifera (WS) is used in Indian folk medicine for the treatment of various musculoskeletal disorders. WS is considered to possess potent antioxidant and anti-inflammatory activities. The aim of the present study was to evaluate the possible mechanism of action of methanolic extract of Withania somnifera roots (WSMe) against collagen induced arthritic (CIA) rats. Arthritis in rats was induced by subcutaneous injection of bovine type II collagen and was treat

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Sultana, Nayma, Sadia Choudhury Shimmi, M. Tanveer Hossain Parash, and Jesmine Akhtar. "Effects of Ashwagandha (Withania somnifera) Root Extract On Some Serum Liver Marker Enzymes (AST, ALT) In Gentamicin Intoxicated Rats." Journal of Bangladesh Society of Physiologist 7, no. 1 (2012): 1–7. http://dx.doi.org/10.3329/jbsp.v7i1.11152.

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Background: Liver is an essential metabolic organ. It can be damaged due to prolonged use and higher doses of drugs, exposure to some chemicals, toxins, or infectious agents. Herbal plants as ashwagandha (Withania somnifera) may have free radical scavenging activity thereby can be used for the prevention and treatment of liver damage.Objective: To observe the effect of ashwagandha (Withania somnifera) root extract on gentamicin induced changes of some liver marker enzymes e,g serum aspartate amino transferase (AST ) and alanine amino transferase (ALT) in Wistar albino rats.Methods: This experi

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Jana, Snehasis. "Physicochemical, Thermal and Spectroscopic Characterization of the Energy of Consciousness Healing Treated Withania somnifera (Ashwagandha) Root Extract." Journal of Natural & Ayurvedic Medicine 5, no. 1 (2021): 1–10. http://dx.doi.org/10.23880/jonam-16000296.

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Ashwagandha root extract is widely used in nutraceutical preparations due to its broad range of pharmacological activities. The objective of this study was to analyse the impact of Biofield Energy Treatment (The Trivedi Effect ® ) on the physico- chemical, thermal and spectral properties of ashwagandha root extract by using various analytical techniques. The sample of ashwagandha root extract was divided into two parts in which one part was kept untreated and called as control sample; while the other part was provided with the Consciousness Energy Healing Treatment remotely by the Biofield Ene

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