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Journal articles on the topic 'Wm 172'

Author: Grafiati

Published: 26 July 2024

Last updated: 31 July 2025

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1

Alotaibi, Abdulmajeed, Anna Podlasek, Amjad AlTokhis, Ali Aldhebaib, Rob A. Dineen, and Cris S. Constantinescu. "Investigating Microstructural Changes in White Matter in Multiple Sclerosis: A Systematic Review and Meta-Analysis of Neurite Orientation Dispersion and Density Imaging." Brain Sciences 11, no. 9 (2021): 1151. http://dx.doi.org/10.3390/brainsci11091151.

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Multiple sclerosis (MS) is characterised by widespread damage of the central nervous system that includes alterations in normal-appearing white matter (NAWM) and demyelinating white matter (WM) lesions. Neurite orientation dispersion and density imaging (NODDI) has been proposed to provide a precise characterisation of WM microstructures. NODDI maps can be calculated for the Neurite Density Index (NDI) and Orientation Dispersion Index (ODI), which estimate orientation dispersion and neurite density. Although NODDI has not been widely applied in MS, this technique is promising in investigating

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Abeykoon, Jithma P., Saurabh Zanwar, Stephen M. Ansell, et al. "Outcomes with rituximab plus bendamustine (R-Benda), dexamethasone, rituximab, cyclophosphamide (DRC), and bortezomib, dexamethasone, rituximab (BDR) as primary therapy in patients with Waldenstrom macroglobulinemia (WM)." Journal of Clinical Oncology 37, no. 15_suppl (2019): 7509. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.7509.

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7509 Background: Waldenstrom macroglobulinemia (WM) is a rare lymphoma for which scant comparative data exist to guide frontline therapy. Herein, we compare 3 commonly used regimens in WM: R-Benda, DRC, and BDR in frontline setting. Methods: Patients (Pts) with active WM seen at Mayo Clinic between 2000 & 2018 who received R-Benda, DRC or BDR as primary therapy were included in this retrospective study. Response rates were assessed by Consensus Criteria. All time to event analyses were performed from the frontline therapy, using Kaplan-Meier method. Results: The study included 172 pts with

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Sabah, Katrina, Nachshon Meiran, and Gesine Dreisbach. "Examining the Trainability and Transferability of Working-Memory Gating Policies." Journal of Cognitive Enhancement 5, no. 3 (2021): 330–42. http://dx.doi.org/10.1007/s41465-021-00205-8.

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AbstractInternal working memory (WM) gating control policies have been suggested to constitute a critical component of task-sets that can be learned and transferred to very similar task contexts (Bhandari and Badre (Cognition, 172, 33–43, 2018). Here, we attempt to expand these findings, examining whether such control policies can be also trained and transferred to other untrained cognitive control tasks, namely to task switching and AX-CPT. To this end, a context-processing WM task was used for training, allowing to manipulate either input (i.e., top-down selective entry of information into W

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Adamia, Sophia, Jennifer Hodges, Patrick M. Pilarski, et al. "Accumulation of Inherited and Acquired Mutations in Hyaluronan Synthase1 Gene May Contribute Oncogenesis in Multiple Myeloma and Waldenstrom’s Macroglobulinemia." Blood 108, no. 11 (2006): 3432. http://dx.doi.org/10.1182/blood.v108.11.3432.3432.

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Abstract In multiple myeloma (MM) and Waldenstrom’s macroglobulinemia (WM), we identified three alternatively and/or aberrantly spliced HAS1 transcripts—HAS1Va, HAS1Vb and HAS1Vc. Statistical analysis of samples taken from 172 untreated MM patients showed that expression of HAS1Vb, an intronic splice variant, strongly correlates with poor survival (P=0.005). We investigated the molecular basis of intron retention during HAS1 splicing in MM and WM patients. We speculated that aberrant HAS1 splicing and the associated reduced survival of MM patients, resulted from an accumulation of mutations in

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Famdan, Famdan, and Arif Hartono. "The Influence of Leadership Style & Environment on Employee Performance With Work Motivation as a Mediation Variable PT. Unilab Perdana." Journal Research of Social Science, Economics, and Management 2, no. 03 (2022): 301–10. http://dx.doi.org/10.59141/jrssem.v2i03.270.

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The title of this research is the analysis of the influence of leadership style (LS) and work environment (WE) on employee performance (EP) with work motivation (WM) as a mediating variable at PT. Prime Unilab. This study aims to determine the mediating effect of work motivation in the relationship between leadership style and work environment on employee performance. This research was conducted quantitatively and used a questionnaire as a data collection method. The population is 300 employees. The research sample used was 172 employees. Therefore, sampling is simple and multiple linear regre

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Dimopoulos, Meletios A., Marie-Christine Kyrtsonis, Evdoxia Hadjiharissi, et al. "Validation of the International Prognostic Scoring System (IPSS) for Waldenstrom's Macroglobulinemia (WM) and the Importance of Serum Lactate Dehydrogenase (LDH)." Blood 114, no. 22 (2009): 2845. http://dx.doi.org/10.1182/blood.v114.22.2845.2845.

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Abstract Abstract 2845 Poster Board II-821 Recently, the IPSS has been proposed as a staging system for patients with WM who require treatment. This system is based on five adverse covariates: age >65 years, hemoglobin '11.5 g/dL, platelet count '100×109/L, beta2-microglobulin >3 mg/L and serum monoclonal protein concentration >7 g/dL. Low risk is defined by the presence of ' 1 adverse characteristic and age '65 years, intermediate risk by the presence of 2 adverse characteristics or only age >65 years and high risk by the presence of >2 adverse characteristics. The aim of our a

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Chaul Barbosa, Caroline, Lisa Marie DeAngelis, and Christian Grommes. "Ibrutinib associated infections: A retrospective study." Journal of Clinical Oncology 35, no. 15_suppl (2017): e19020-e19020. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e19020.

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e19020 Background: Ibrutinib (IBRU) is a Bruton tyrosine kinase (BTK) inhibitor that has been FDA approved for chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL) and Waldenstrom's Macroglobulinemia (WM). BTK inhibition may contribute to immunosuppression through B- and T-cell inhibition, resulting in an increase in infections. We therefore characterized IBRU-related infections retrospectively. Methods: The study was an IRB approved retrospective review. Patients (pts) treated with IBRU between 4/2014-11/2016 who developed any infection were identified using ICD10 codes in a clinica

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Dale, David C., Steven P. Treon, David F. McDermott, et al. "Oral Administration of Mavorixafor, a CXCR4 Antagonist, Increases Peripheral White Blood Cell Counts across Different Disease States." Blood 138, Supplement 1 (2021): 2186. http://dx.doi.org/10.1182/blood-2021-152990.

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Abstract Introduction: Peripheral leukocyte deficiency is a common feature of multiple diseases and may render affected individuals susceptible to infections, both common and opportunistic. The CXCR4 chemokine receptor regulates the trafficking of leukocytes among the bone marrow, blood, and lymphatic system (Al Ustwani O, et al. Br J Haematol. 2014;164:15-23). Mavorixafor is an orally available investigational, small-molecule, selective antagonist of the CXCR4 receptor with potential to restore physiological trafficking and maturation of white blood cells (WBCs). Mavorixafor was previously sh

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Lu, Jiadong, Songli Zhang, Leizhi Zhang, Chenxi Wang, and Chunying Min. "Preparation and Properties of Hollow Glass Microspheres/Dicyclopentadiene Phenol Epoxy Resin Composite Materials." Materials 16, no. 10 (2023): 3768. http://dx.doi.org/10.3390/ma16103768.

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With the development of the integrated circuit and chip industry, electronic products and their components are becoming increasingly miniaturized, high-frequency, and low-loss. These demand higher requirements for the dielectric properties and other aspects of epoxy resins to develop a novel epoxy resin system that meets the needs of current development. This paper employs ethyl phenylacetate cured dicyclopentadiene phenol (DCPD) epoxy resin as the matrix and incorporates KH550 coupling-agent-treated SiO2 hollow glass microspheres to produce composite materials with low dielectric, high heat r

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Kriangkum, Jitra, Andrew R. Belch, and Linda M. Pilarski. "Clinically Significant Aberrant HAS1Vb Splicing of the Hyaluronan Synthase 1 Gene (HAS1) Requires a Combination of Mutations and Deletions in Introns 3 and 4 of HAS1 Minigene,." Blood 118, no. 21 (2011): 3931. http://dx.doi.org/10.1182/blood.v118.21.3931.3931.

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Abstract Abstract 3931 Clinically important aberrant splicing of the hyaluronan synthase 1 gene (HAS1) occurs in malignant B cells from multiple myeloma (MM) and Waldenstrom macroglobulimenia (WM) patients but is undetectable in B cells from healthy donors (HD)1. HAS1 splice variants are generated by aberrant alternative splicing (AS) within exons 3, 4 and 5, involving exon 4 skipping (Va), partial intron 4 retention (Vc, Vd) or a combination of both (Vb). Aberrant splicing of HAS1Vb has previously shown to correlate with reduced survival in a cohort of MM patients1. In patients, frequent muta

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Kobuszewski, Bartosz, Piotr Winciunas, Jacek Pruszyński, and Wojciech Stefan Zgliczyński. "Sickness absence in 2019-2020 and the activities of the Social Insurance Institution (ZUS) to prevent incapacity for work." Wiedza Medyczna 4, no. 1 (2022): 33–38. http://dx.doi.org/10.36553/wm.112.

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Sickness absence is an important measure of the current situation on the labor market and a source of information on the health condition of the working part of the society. It is also a phenomenon that directly affects the economy. Monitoring the size and causes of sickness absence enables the adjustment of the social and health policy in the country. In Poland, sickness absence is most often analyzed in the context of people receiving sickness allowance - a benefit from the social security system granted to insured persons in the event of incapacity to work due to illness. In 2020, there wer

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Ostrowski, Janusz, Wojciech Stefan Zgliczyński, Jarosław Pinkas, and Ryszard Gellert. "History of the School of Public Health at the Centre of Postgraduate Medical Education (1971 to 2021)." Wiedza Medyczna 4, no. 1 (2022): 1–7. http://dx.doi.org/10.36553/wm.132.

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The 50th anniversary of the Centre of Postgraduate Medical Education (CMKP) was celebrated in 2021. Since the beginning, the School of Public Health (SZP) has been inseparable linked with the CMKP. Throughout this period, the position of the SZP director has been held by eight persons i.e. Bogusław Kożusznik (1971 to 1977), Marek Sanecki (1978 to 1991), Andrzej Wojtczak (1991 to 1996), Jerzy Leowski (1996 to 2003), Janusz Opolski (2003 to 2004 and 2005 to 2011), Maria Miller (2005 to 2005), Dorota Cianciara (2011 to 2018) and Jarosław Pinkas (since 2018). In the paper, the consecutive director

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Grudziąż-Sękowska, Justyna, Jacek Pruszyński, Paweł Goryński, et al. "The situation of people suffering from diabetes in Poland. Needs of changes in the health care system." Wiedza Medyczna 4, no. 1 (2022): 53–57. http://dx.doi.org/10.36553/wm.122.

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Diabetes mellitus affects about 3 million Poles, which is almost 8% of the population. It belongs to the national health priorities defined in the regulation of the Minister of Health. If poorly controlled, it leads to the development of many serious complications, both acute and chronic. It excludes people who are often of productive age from an effective, satisfactory life, and therefore causes an increase in public costs due to health and social insurance, and a decrease in state budget revenues from production and consumption. Measures taken in the areas of: population prevention addressed

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Dalal, Nicole H., Graca Dores, Rochelle E. Curtis, Martha S. Linet, and Lindsay M. Morton. "Cause-specific mortality in survivors of lymphoplasmacytic lymphoma (LPL) and waldenstrom macroglobulinemia (WM)." Journal of Clinical Oncology 37, no. 15_suppl (2019): e19056-e19056. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e19056.

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e19056 Background: LPL and WM are rare, indolent mature B-cell lymphomas. While recent studies reveal improving survival after LPL/WM, cause-specific mortality has not been comprehensively studied. Methods: We identified 6659 adults with first primary LPL (n = 2866) or WM (n = 3793) within 17 US population-based cancer registries from 2000 to 2015. Patients were followed for vital status (mean follow-up = 5.07 years), and causes of death were determined from death certificates. Standardized mortality ratios (SMRs) estimated relative risk of death compared to the general population. We estimate

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Nguyen-Khac, Florence, Julie Lejeune, Elise Chapiro, et al. "Cytogenetic Abnormalities In a Cohort of 171 Patients with Waldenström Macroglobulinemia Before Treatment: Clinical and Biological Correlations." Blood 116, no. 21 (2010): 801. http://dx.doi.org/10.1182/blood.v116.21.801.801.

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Abstract Abstract 801 The genetic bases of Waldenström Macroglobulinemia (WM) are poorly understood. Because of the difficulty in obtaining tumor metaphases for karyotype studies, few recurrent chromosomal abnormalities have been reported in WM. We have studied a cohort of 171 untreated WM patients, enrolled in a prospective randomized trial from the French Cooperative Group on Chronic Lymphocytic Leukemia and Waldenstrom Macroglobulinemia (FCG-CLL/WM) comparing the efficacy of fludarabine to that of chlorambucil, by conventional cytogenetic (CC) and Fluorescence in situ hybridization (FISH).

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Landgren, Ola, Sigurdur Y. Kristinsson, Lynn R. Goldin, et al. "Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden." Blood 114, no. 4 (2009): 791–95. http://dx.doi.org/10.1182/blood-2008-12-191676.

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Abstract Familial clustering of the precursor condition, monoclonal gammopathy of undetermined significance (MGUS) has been observed in case reports and in smaller studies. Using population-based data from Sweden, we identified 4458 MGUS patients, 17505 population-based controls, and first-degree relatives of patients (n = 14621) and controls (n = 58387) with the aim to assess risk of MGUS and lymphoproliferative malignancies among first-degree relatives of MGUS patients. Compared with relatives of controls, relatives of MGUS patients had increased risk of MGUS (relative risk [RR] = 2.8; 1.4-5

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Silva, Denia, and Orbel Canoy. "Formation Process for Religious Life of the Oblate Sisters of Saint Joseph in the Philippines: A SWOT Analysis." Psychology and Education: A Multidisciplinary Journal 27, no. 5 (2024): 557–63. https://doi.org/10.5281/zenodo.14030869.

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This thesis explores the evaluation of the formation process within the OSSJ through a comprehensive SWOT analysis, highlighting the program's strengths, weaknesses, opportunities, and threats across several critical dimensions: formation programs, supervision, facility maintenance, funding, and personnel. The findings reveal that the formation program is well-regarded, effectively addressing its members' spiritual and practical needs (WM = 3.9) and demonstrating a structured curriculum (WM = 4.0). However, the program struggles to adapt to contemporary religious practices (WM = 1.4) and lacks

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Wang, Q., C. Cheung, W. Deng, et al. "Fronto-parietal white matter microstructural deficits are linked to performance IQ in a first-episode schizophrenia Han Chinese sample." Psychological Medicine 43, no. 10 (2012): 2047–56. http://dx.doi.org/10.1017/s0033291712002905.

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BackgroundEvidence shows that cognitive deficits and white matter (WM) dysconnectivity can independently be associated with clinical manifestations in schizophrenia. It is important to explore this triadic relationship in order to investigate whether the triplet could serve as potential extended endophenotypes of schizophrenia.MethodDiffusion tensor images and clinical performances were evaluated in 122 individuals with first-episode schizophrenia and 122 age- and gender-matched controls. In addition, 65 of 122 of the patient group and 40 of 122 controls were measured using intelligence quotie

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Ikeda, Yoshifumi, Yosuke Kita, Yuhei Oi, et al. "The Structure of Working Memory and Its Relationship with Intelligence in Japanese Children." Journal of Intelligence 11, no. 8 (2023): 167. http://dx.doi.org/10.3390/jintelligence11080167.

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There is a host of research on the structure of working memory (WM) and its relationship with intelligence in adults, but only a few studies have involved children. In this paper, several different WM models were tested on 170 Japanese school children (from 7 years and 5 months to 11 years and 6 months). Results showed that a model distinguishing between modalities (i.e., verbal and spatial WM) fitted the data well and was therefore selected. Notably, a bi-factor model distinguishing between modalities, but also including a common WM factor, presented with a very good fit, but was less parsimo

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Treon, Steven, Zachary Hunter, Bryan Ciccarelli, et al. "IgA and IgG Hypogammaglobulinemia Is a Constitutive Feature in Most Waldenstrom’s Macroglobulinemia Patients and May Be Related to Mutations Associated with Common Variable Immunodeficiency Disorder (CVID)." Blood 112, no. 11 (2008): 3749. http://dx.doi.org/10.1182/blood.v112.11.3749.3749.

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Abstract Background: Hypogammaglobulinemia of the “uninvolved” immunoglobulins is commonly observed in Waldenstrom’s macroglobulinemia (WM), and has often been attributed to disease-related suppression. However, there is a paucity of information related to the pathogenesis of hypogammaglobulinemia in these disorders. Methods: We evaluated the incidence of IgA and IgG hypogammaglobulinemia in 207 patients with WM, and addressed the impact of therapy and response on IgA and IgG levels for 93 of these patients who required subsequent treatment. We also performed extensive sequence analysis of the

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Xu, Lian, Zachary Hunter, Nicholas Tsakmaklis, et al. "The Clonal Architecture of CXCR4mutations in Waldenstrom's Macroglobulinemia Shows Highly Variable Subclonal Distribution, and Multiple Mutations within Individual Patients Indicative of Targeted Genomic Instability." Blood 126, no. 23 (2015): 1486. http://dx.doi.org/10.1182/blood.v126.23.1486.1486.

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Abstract Background: Whole genome sequencing (WGS) identified activating CXCR4WHIM somatic mutations in nearly 30% of patients with Waldenstrom's Macroglobulinemia (WM) (Blood 123(11):1637-46). Both nonsense and frameshift CXCR4WHIM mutations occur in WM, with over 30 different types of mutations described within the regulatory carboxyl-terminal domain of CXCR4. CXCR4WHIM mutations almost always occur with activating MYD88 mutations, and impact both disease presentation and treatment outcome (Blood 123(18):2791-6; NEJM 372(15):1430-40.). The clonal architecture of CXCR4WHIM mutations relative

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Ciccarelli, Bryan, Christopher J. Patterson, Zachary Hunter, et al. "Patients with Waldenstrom's Macroglobulinemia Are Often Hypoferremic That Is Refractory to Oral Iron Repletion and Responsive to Parental Iron Infusions, and Demonstrate Elevated Levels of Hepcidin." Blood 114, no. 22 (2009): 2952. http://dx.doi.org/10.1182/blood.v114.22.2952.2952.

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Abstract Abstract 2952 Poster Board II-928 Background: Patients with Waldenstrom's macroglobulinemia (WM) often present with anemia, that can occur independent of bone marrow disease involvement, serum IgM levels, and in the absence of any hemolysis (Treon, Blood 2009). Iron deficiency is commonly observed in WM patients, and is often oral iron refractory. Parenteral administration of iron (Ferrlicit) in such patients can lead to improvements in hematocrit in patients who are oral iron refractory as shown below in Table 1: As such, we investigated mechanisms by which oral iron uptake could be

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Ntim, Stephen K. "Working Memory Failures and Comprehension Monitoring Impairments in Primary Readers." Psychology and Cognitive Sciences – Open Journal 9, no. 1 (2023): 17–26. http://dx.doi.org/10.17140/pcsoj-9-170.

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Background This paper investigates the relationship between working memory (WM) failures and comprehension impairments in text comprehension among L2 primary readers in primary four through primary six in selected schools in Ghana. Method Five measures—decoding, vocabulary, working memory, comprehension monitoring, and reading comprehension—were used to test three research questions on the L2 primary reader’s ability to notice inconsistencies in paragraphs, stronger academic language, re-reading times for mismatched words in sentences, and self-reporting and comprehension. Results Major findin

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Croucher, Danielle C., Victor H. Jimenez-Zepeda, Zhi Hua Li, et al. "The Potent STAT3/5 Inhibitor, BP-1-102 Demonstrates Significant Anti-Tumor Activity Against Waldenström Macroglobulinemia." Blood 118, no. 21 (2011): 5101. http://dx.doi.org/10.1182/blood.v118.21.5101.5101.

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Abstract Abstract 5101 STAT3 is a cytoplasmic transcription factor, transiently activated in response to external stimuli such as growth factors and cytokines. As a transcription factor, STAT3 induces the expression of genes known to be involved in tumorigenesis, implicating STAT3 dysregulation in a number of hallmark oncogenic processes including tumor cell survival, proliferation, angiogenesis, metastasis, and drug resistance. Aberrant STAT3 signaling is prevalent in hematologic malignancies including Waldenstrom Macroglobulinemia (WM), a rare form of B cell non-Hodgkin lymphoma that is char

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Chen, Jia, Jian Li, Daobin Zhou, and Xinxin Cao. "Modified Staging System for Patients with Waldenstrom's Macroglobulinemia in a Chinese Cohort." Blood 144, Supplement 1 (2024): 6892. https://doi.org/10.1182/blood-2024-210305.

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Waldenström macroglobulinemia (WM) has been recognized as a rare subtype of low-grade B-cell lymphoma. Although WM mostly has an indolent course and the prognosis has improved during the last decades, WM remains incurable and perpetually relapse and most patients succumb to disease progression. Prognostic parameters of WM have been reexamined and a modified staging system of WM (MSS-WM) has been formulated recently. However, the derivation and validation cohorts included predominantly patients from the USA and Europe Our aim was to provide evidence of MSS-WM for 294 symptomatic WM patients in

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Hunter, Z. R., K. O'Connor, J. Soumerai, et al. "IgG and IgA hypogammaglobulinemia is pervasive in Waldenstrom's macroglobulinemia (WM) and persists regardless of response or type of therapeutic intervention." Journal of Clinical Oncology 25, no. 18_suppl (2007): 8042. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.8042.

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8042 Background: IgG and IgA hypogammaglobulinemia (HG) is a commonly observed in patients with WM and has often been attributed to the extensive infiltration of lymphoplasmacytic cells in the bone marrow (BM). Methods: In this retrospective study we analyzed immunoglobulin and BM infiltration levels from 196 previously untreated patients at their first visit to our clinic who met the clinical and pathological criteria for WM. In addition, we also serially evaluated 65 WM patients who received various therapies for changes in IgA and IgG. All lab values and biopsies used were conducted at our

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Gardi, Romain. "Les premiers débats tactiques de l’équipe de France. La Coupe du monde de football de 1934 et la difficile diffusion du WM en France." Football(s). Histoire, culture, économie, société, no. 1 (November 17, 2022): 53–61. http://dx.doi.org/10.58335/football-s.112.

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Le WM est la principale innovation tactique de l’entre-deux-guerres. Adaptation à la modification de la règle du hors-jeu de 1925, ce schéma tactique est diffusé par les matchs de l’équipe d’Arsenal et des entraîneurs britanniques comme William Aitken ou Gabriel Sibley Kimpton. Ce dernier l’introduit dans le jeu de l’équipe de France participant à la Coupe du monde 1934, mais le WM ne fait pas l’unanimité parmi les joueurs et les clubs français et cette défiance contribue au manque d’identité et style du jeu hexagonal. Il n’en est pas moins utilisé par des équipes amateures notamment dans le V

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Paludo, Jonas, Shayna R. Sarosiek, Gottfried R. von Keudell, et al. "Real-World Treatment Patterns and Healthcare Resource Utilization in Patients with Waldenström Macroglobulinemia Initiating First-Line Treatment with Ibrutinib or Zanubrutinib." Blood 142, Supplement 1 (2023): 7385. http://dx.doi.org/10.1182/blood-2023-181053.

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Background: A pivotal clinical trial comparing the efficacy and safety of ibrutinib with zanubrutinib in patients with Waldenström macroglobulinemia (WM) did not achieve its primary endpoint of complete response or very good partial response. In addition, median progression-free survival was not reached in either treatment arm. In the absence of treatment effectiveness differentiation based on clinical trial evidence, we conducted a real-world study to assess patient characteristics, treatment patterns, and all-cause healthcare resource utilization (HRU) in patients with WM who received ibruti

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Kimble, Alisha Monnette, Nicholas J. Robert, Junxin Shi, Debra Rembert, Melanie Bamberg, and Robert Reid. "Descriptive epidemiology of Waldenström macroglobulinemia (WM): Demographics, outcomes, and predictors of survival in the US community oncology setting." Journal of Clinical Oncology 43, no. 16_suppl (2025): 7064. https://doi.org/10.1200/jco.2025.43.16_suppl.7064.

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7064 Background: WM is a rare, indolent subtype of non-Hodgkin lymphoma (NHL), comprising <2% of annual U.S. NHL cases. Natural history studies and registries often lack sufficient patient-level data about treatment patterns and outcomes. This study describes demographics, clinical characteristics, and outcomes of patients with WM treated in the community oncology setting. Methods: This retrospective cohort study included adults diagnosed with WM in the U.S. Oncology Network from 2014 to 2022, with follow-up through 2023. Data were sourced from the iKnowMed electronic health record system.

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Chalmers, Kerry A., and Emily E. Freeman. "Working Memory Power Test for Children." Journal of Psychoeducational Assessment 37, no. 1 (2017): 105–11. http://dx.doi.org/10.1177/0734282917731458.

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Low working memory (WM) capacity has been linked to poor academic performance and problem behavior. Availability of easy-to-administer screening tests would facilitate early detection of WM deficits. This study investigated the psychometric properties of the Working Memory Power Test for Children (WMPT) in 170 Australian schoolchildren (8½-11 years). Reliability (internal consistency) and validity of WMPT accuracy scores were examined. WMPT accuracy predicted achievement in reading, numeracy, and spelling. The results provide preliminary evidence of reliability and validity that supports inter

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Pergola, G., P. Di Carlo, I. Andriola, et al. "Combined effect of genetic variants in the GluN2B coding gene(GRIN2B)on prefrontal function during working memory performance." Psychological Medicine 46, no. 6 (2015): 1135–50. http://dx.doi.org/10.1017/s0033291715002639.

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BackgroundThe GluN2B subunit ofN-methyl-d-aspartate receptors is crucially involved in the physiology of the prefrontal cortex during working memory (WM). Consistently, genetic variants in the GluN2B coding gene (GRIN2B) have been associated with cognitive phenotypes. However, it is unclear howGRIN2Bgenetic variation affects gene expression and prefrontal cognitive processing. Using a composite score, we tested the combined effect ofGRIN2Bvariants on prefrontal activity during WM performance in healthy subjects.MethodWe computed a composite score to combine the effects of single nucleotide pol

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Kyriakou, Charalampia, C. Canals, A. Sureda, et al. "The Role of Autologous Stem Cell Transplantation (ASCT) in Patients with Advanced Waldenström’s Macroglobulinemia." Blood 110, no. 11 (2007): 941. http://dx.doi.org/10.1182/blood.v110.11.941.941.

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Abstract Waldenström’s macroglobulinaemia (WM) is a relatively rare disorder that primarily affects elderly patients. Conventional therapies for symptomatic WM result in response rates of up to 70%. However, complete responses are rare and the disease remains incurable. Due to the indolent nature of the disease and the older age of patients the role of autologous stem cell transplantation (ASCT) in the treatment of patients with WM has not been analyzed in large series. In this retrospective multicenter study we report the outcome of 201 WM patients (132 male, 69 female), who underwent ASCT b

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Kristinsson, Sigurdur Y., Magnus Bjorkholm, Jill Koshiol, et al. "Immune-Related and Inflammatory Conditions Likely Play a Role in the Development of Lymphoplasmacytic Lymphoma/Waldenström’s Macroglobulinemia." Blood 112, no. 11 (2008): 3758. http://dx.doi.org/10.1182/blood.v112.11.3758.3758.

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Abstract Introduction: Certain autoimmune and infectious conditions are associated with increased risks of subtypes of non-Hodgkin lymphomas (NHL). A few prior studies suggest that chronic immune stimulation may particularly elevate risk for the NHL subtype lymphoplasmacytic lymphoma (LPL)/Waldenström’s macroglobulinemia (WM). To improve our understanding on the role of immune-related and inflammatory conditions in LPL/WM pathogenesis, we conducted a large population-based study including close to 2,500 LPL/WM patients diagnosed in Sweden and almost 10,000 matched controls. Methods: Using bot

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Berner, Lise-Prune, Tae-Hee Cho, Julie Haesebaert, et al. "MRI Assessment of Ischemic Lesion Evolution within White and Gray Matter." Cerebrovascular Diseases 41, no. 5-6 (2016): 291–97. http://dx.doi.org/10.1159/000444131.

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Background: In acute ischemic stroke (AIS), gray matter (GM) and white matter (WM) have different vulnerabilities to ischemia. Thus, we compared the evolution of ischemic lesions within WM and GM using MRI. Methods: From a European multicenter prospective database (I-KNOW), available T1-weighted images were identified for 50 patients presenting with an anterior AIS and a perfusion weighted imaging (PWI)/diffusion weighted imaging (DWI) mismatch ratio of 1.2 or more. Six lesion compartments were outlined: initial DWI (b = 1,000 s/mm2) lesion, initial PWI-DWI mismatch (Tmax >4 s and DWI-negat

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Wang, Jun, Yuting Yan, Wenjie Xiong, et al. "The Landscape of Immunoglobulin Heavy Chain Gene Repertoire in Lymphoplasmacytic Lymphoma / Waldenström Macroglobulinemia." Blood 138, Supplement 1 (2021): 1346. http://dx.doi.org/10.1182/blood-2021-149397.

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Abstract Introduction Immunoglobulin heavy-chain variable genes (IGHV) is critical for the defining epitope binding affinityand B cell differentiation. Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) is a heterogeneous diseasewhose role of IGHV usage remains unknown. Besides, the clinical relevance of IGHV repertoire for LPL/WM remain largely unexplored. The aim of our study is to explore the IGH repertoire of LPL/WM in by far the largest series, and to evaluate the correlation between IGH rearrangements and genetic aberrations and clinical characteristics of LPL/WM patients.

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SUGAWARA, Takeru, Hiroaki HASEGAWA, and Takumi OKADA. "112 Low Speed Wm Tunnel Tests Using Magnetic Suspension and Balance System." Proceedings of Conference of Tohoku Branch 2004.39 (2004): 24–25. http://dx.doi.org/10.1299/jsmeth.2004.39.24.

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Pavlakis, K. G., D. Hatzidimitriou, C. Matsoukas, E. Drakakis, N. Hatzianastassiou, and I. Vardavas. "Ten-year global distribution of downwelling longwave radiation." Atmospheric Chemistry and Physics 4, no. 1 (2004): 127–42. http://dx.doi.org/10.5194/acp-4-127-2004.

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Abstract. Downwelling longwave fluxes, DLFs, have been derived for each month over a ten year period (1984-1993), on a global scale with a spatial resolution of 2.5x2.5 degrees and a monthly temporal resolution. The fluxes were computed using a deterministic model for atmospheric radiation transfer, along with satellite and reanalysis data for the key atmospheric input parameters, i.e. cloud properties, and specific humidity and temperature profiles. The cloud climatologies were taken from the latest released and improved International Satellite Climatology Project D2 series. Specific humidity

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Kicińska, Urszula. "„Co moment wyglądałam łaski Pańskiej WM Pani i Dobrodziki" – korespondencja Elżbiety z Lubomirskich Sieniawskiej, kasztelanowej krakowskiej z Joanną Gołyńską, ksienią jarosławskich benedyktynek jako przykład relacji klientalnych w czasach saskich." Archiwa, Biblioteki i Muzea Kościelne 120 (June 30, 2023): 241–60. http://dx.doi.org/10.31743/abmk.13233.

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W dawnej Polsce kobiety mocno angażowały się w działalność publiczną, a jednym z jej przejawów był sprawowany przez nie patronat religijny, który stanowił bardzo ważny element budowania więzi klientalnych. Znakomitym materiałem służącym do prześledzenia relacji pomiędzy daną patronką a jej duchowną klientelą są listy proszalne, w których pod pokładami rozbudowanej ceremonialności pojawiały się rzeczywiste cele i oczekiwania obu negocjujących ze sobą stron. W gronie owych zacnych kolatorek znalazła się również Elżbieta z Lubomirskich Sieniawska (zm. 1729), która wraz ze swym mężem Adamem Mikoła

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Park, Soon O., Dermot P. Coyne, James R. Steadman, Paul W. Skroch, and Geunhwa Jung. "550 Mapping of QTL for Partial Physiological Resistance and Field Reaction to White Mold, Plant Architecture, and Plant Height in Common Bean." HortScience 35, no. 3 (2000): 490D—490. http://dx.doi.org/10.21273/hortsci.35.3.490d.

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The objective was to detect molecular markers associated with QTL for partial physiological resistance (PPR) to two white mold (WM) isolates, partial field resistance (PFR), plant architecture (PA), and plant height (PH) in a genetic linkage map constructed using recombinant inbred lines (RILs) from the cross `PC-50' (resistant to WM) × XAN-159 (susceptible to WM). Significant correlations (+0.39 and +0.47) were noted between the WM reactions in the greenhouse and field. A significant but negative correlation (–0.33) was observed between the WM reaction and PH in the field. Six QTL affecting P

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Castillo, Jorge J., Adam J. Olszewski, Sandra Kanan, Kirsten Meid, Zachary Hunter, and Steven P. Treon. "Incidence and Survival Outcomes of Secondary Malignancies Among Survivors of Waldenström Macroglobulinemia." Blood 124, no. 21 (2014): 855. http://dx.doi.org/10.1182/blood.v124.21.855.855.

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Abstract Background: Waldenstrom macroglobulinemia (WM) is an indolent malignancy characterized by extended survival, and affects predominantly older individuals, who are at risk for secondary malignancies (SM). The objectives of our study were to characterize incidence and outcomes of SM after WM diagnosis using the Surveillance, Epidemiology and End Results (SEER) database. Methods: Using the SEER-13 data from 1992-2011, we calculated standardized incidence ratios (SIR) with 95% confidence intervals (CI) for rates of solid and hematologic SM in WM patients compared with matched general popul

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Sanford, Nicole, and Todd S. Woodward. "Functional Delineation of Prefrontal Networks Underlying Working Memory in Schizophrenia: A Cross-data-set Examination." Journal of Cognitive Neuroscience 33, no. 9 (2021): 1880–908. http://dx.doi.org/10.1162/jocn_a_01726.

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Abstract Background: Working memory (WM) impairment in schizophrenia substantially impacts functional outcome. Although the dorsolateral pFC has been implicated in such impairment, a more comprehensive examination of brain networks comprising pFC is warranted. The present research used a whole-brain, multi-experiment analysis to delineate task-related networks comprising pFC. Activity was examined in schizophrenia patients across a variety of cognitive demands. Methods: One hundred schizophrenia patients and 102 healthy controls completed one of four fMRI tasks: a Sternberg verbal WM task, a v

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Berlanga, Oscar, Jane Birtwistle, Syreeta Allen, et al. "Multi-Center Clinical Validation of a Mass Spectrometry Immunoassay for the Diagnosis and Monitoring of Multiple Myeloma and Associated Disorders." Blood 142, Supplement 1 (2023): 3667. http://dx.doi.org/10.1182/blood-2023-189050.

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Introduction: Mass spectrometry (MS) technology holds great promise for the investigation of monoclonal proteins (M proteins) in peripheral blood. We present results from a multi-center clinical validation study using quantitative immunoprecipitation MS (QIP-MS). QIP-MS combines isotype-specific immunopurification with matrix-assisted laser-desorption ionization MS, and offers automated, sensitive detection, isotyping and quantification of M proteins. It reports the mass/charge ratio (m/z) of the involved light chain, which serves as molecular fingerprint for monitoring the M protein. Methods:

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Aoki, H., M. Takishita, M. Kosaka, and S. Saito. "Frequent somatic mutations in D and/or JH segments of Ig gene in Waldenstrom's macroglobulinemia and chronic lymphocytic leukemia (CLL) with Richter's syndrome but not in common CLL." Blood 85, no. 7 (1995): 1913–19. http://dx.doi.org/10.1182/blood.v85.7.1913.bloodjournal8571913.

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V(D)J recombination and somatic hypermutations are developmentally regulated during B-cell differentiation; therefore, DNA analysis of the Ig gene delineates the cellular origin of B-cell neoplasms. We analyzed the third complementarity-determining region and adjacent regions of the Ig heavy-chain gene of tumor cells from 7 patients with Waldenstrom's macroglobulinemia (WM) and from 10 patients with B-cell chronic lymphocytic leukemia (CLL), 2 of whom progressed to high-grade non-Hodgkin's lymphoma (NHL), ie, Richter's syndrome (RS). There were no intraclonal variations resulting from VH repla

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Vincenzi, Margherita, Erika Borella, Enrico Sella, César F. Lima, Rossana De Beni, and E. Glenn Schellenberg. "Music Listening, Emotion, and Cognition in Older Adults." Brain Sciences 12, no. 11 (2022): 1567. http://dx.doi.org/10.3390/brainsci12111567.

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Using the arousal and mood hypothesis as a theoretical framework, we examined whether community-dwelling older adults (N = 132) exhibited cognitive benefits after listening to music. Participants listened to shorter (≈2.5 min) or longer (≈8 min) excerpts from recordings of happy- or sad-sounding music or from a spoken-word recording. Before and after listening, they completed tasks measuring visuospatial working memory (WM), cognitive flexibility and speed, verbal fluency, and mathematical ability, as well as measures of arousal and mood. In general, older adults improved from pre- to post-tes

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Song, Yan, Mengyu Chai, Junnan Lv, et al. "Creep rupture behavior of 2.25Cr1Mo0.25V steel and weld for hydrogenation reactors under different stress levels." REVIEWS ON ADVANCED MATERIALS SCIENCE 61, no. 1 (2022): 334–49. http://dx.doi.org/10.1515/rams-2022-0037.

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Abstract In the present research work, the 2.25Cr1Mo0.25V steel plates with a thickness of 112 mm were welded using the multi-pass submerged automatic arc welding process. The creep specimens were prepared from the base metal (BM) and weld metal (WM) in the welded joint after heat treatment process. The uniaxial creep tests were performed to investigate the creep deformation and rupture behaviors at 550°C under different applied stress levels. The microstructure and fracture surface morphology of crept BM and WM samples were also characterized using the scanning electron microscope with energy

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Yang, Guang, Xia Liu, Jie Chen, et al. "Targeting IRAK1/IRAK4 Signaling in Waldenstrom's Macroglobulinemia." Blood 126, no. 23 (2015): 4004. http://dx.doi.org/10.1182/blood.v126.23.4004.4004.

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Abstract Background: MYD88 L265P somatic mutations are highly prevalent in Waldenström's macroglobulinemia (WM) (NEJM 367(9):826-33). MYD88 L265P activates multiple downstream signaling pathways including BTK and IRAK1/IRAK4 that support malignant cell growth and survival (Nature 470(7332):115-9; Blood 122(7):1222-32). Ibrutinib targets BTK, and shows high overall and major clinical response rates, though no complete responses are observed indicating alternative survival signaling. Methodology: Phospho-flow analysis of IRAK1, IRAK4, and BTK was performed in primary WM cells taken from untreate

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Hanzis, Christina, Zachary Hunter, Robert Manning, et al. "Associated Malignancies Among Patients and Kin with Waldenstrom's Macroglobulinemia." Blood 116, no. 21 (2010): 4159. http://dx.doi.org/10.1182/blood.v116.21.4159.4159.

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Abstract Abstract 4159 Waldenstrom's macroglobulinemia (WM) is a B-cell malignancy characterized as an IgM secreting lymphoplasmacytic lymphoma. Familial predisposition is common in WM. Studies to date by us and others have revealed three identifiable clinical subtypes for WM predisposition: * Sporadic; proband has WM, but there is an absence of WM or other B-cell disorders in other family members; * Familial, Mixed B-cell Disorders Subtype; proband has WM, and various B-cell disorders are manifested by other family members. * Familial, WM Only Subtype; proband has WM, and only WM is present i

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Regmi, Santosh, and Sunil Adhikary. "Solar Energy Potential in Kathmandu Valley, Nepal." Journal of Hydrology and Meteorology 8, no. 1 (2016): 77–82. http://dx.doi.org/10.3126/jhm.v8i1.15576.

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Meteorological data such as solar radiation (1975-1984, and 2002-2010) and sunshine duration (1968-2004) were analyzed to study temporal characteristics of solar energy and investigate solar energy potential in Kathmandu valley. Pre-monsoon and post monsoon seasons have higher mean monthly sunshine duration (about 8 hours/day) than summer (about 5 hours/day) and winter (about 7 hours/day) seasons over Kathmandu. Pre-monsoon and monsoon seasons receive solar energy of about 190 Wm-2 and 170 Wm-2 respectively. The winter season receives the least amount of solar radiation (135 Wm-2). Approximate

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Ricca, Irene, Giacomo Tamponi, Celeste Arnò, et al. "Epidemiology of Plasma Cell Disorders in a General Hospital: A Retrospective Study of 102 Patients." Blood 110, no. 11 (2007): 4754. http://dx.doi.org/10.1182/blood.v110.11.4754.4754.

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Abstract INTRODUCTION Plasma cell disorders are a group of diseases characterized by the proliferation of a plasma cell clone which produces a monoclonal protein (M protein). The most common type is Monoclonal Gammopathies of Undetermined Significance (MGUS), followed by multiple myeloma (MM) and Waldenstrom’s Macroglobulinemia (WM). In particular, the frequency of MGUS increases with age and its rate of progression is approximately 1% per year. Because of the high prevalence and the different fields of clinical practice in which these patients are followed, it could be of great interest to kn

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Paba-Prada, Claudia E., Ranjit Banwait, Steven Treon, and Irene M. Ghobrial. "Incidence of Peripheral Neuropathy in Waldenström Macroglobulinemia Patients At Diagnosis,." Blood 118, no. 21 (2011): 3692. http://dx.doi.org/10.1182/blood.v118.21.3692.3692.

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Abstract Abstract 3692 INTRODUCTION: Waldenström Macroglobulinemia (WM) is a rare indolent B-cell lymphoma characterized by lymphoplasmacytic infiltration of the bone marrow and a monoclonal immunoglobulin M (IgM). One common complication of WM is peripheral neuropathy (PN). However, the incidence of PN in WM has not been established. The most frequent neurologic abnormality is distal, symmetric, and slowly progressive sensorimotor polyneuropathy characterized by paresthesias and weakness. Although the exact pathogenesis remains unclear, neurological complications of WM can occur as a result

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