Journal articles: 'WNA 350'

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Dundar, Ibrahim, Marina Krichevskaya, Atanas Katerski, Malle Krunks, and Ilona Oja Acik. "Photocatalytic Degradation of Different VOCs in the Gas-Phase over TiO2 Thin Films Prepared by Ultrasonic Spray Pyrolysis." Catalysts 9, no. 11 (2019): 915. http://dx.doi.org/10.3390/catal9110915.

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In this study, we deposited TiO2 thin films onto borosilicate glass by ultrasonic spray pyrolysis at 350 and 450 °C. The aim of study is to determine the effect of deposition temperature on photocatalytic activity of TiO2 thin films and to investigate the performance of TiO2 thin films on photocatalytic degradation of methyl tert-butyl ether (MTBE), acetone, acetaldehyde, and heptane as functions of different operating parameters. TiO2 thin films deposited at 350 and 450 °C have a thickness value of 190 and 330 nm, respectively. All as-prepared TiO2 films possess an anatase crystalline structure. According to the X-ray photon spectroscopy (XPS) study, the TiO2 thin film deposited at 350 °C showed a higher amount of oxygen vacancies and hydroxyl groups on the film surface after UV treatment. The aged-TiO2 thin film deposited at 350 °C showed a water contact angle (WCA) value of 0° after 10 min UV irradiation, showing superhydrophilic surface behavior. The TiO2 film deposited at 350 °C exhibited the highest amount of conversion of MTBE (100%). The results also showed that TiO2 films are capable of photocatalytic degradation of MTBE (100%) and acetaldehyde (approx. 80%) in humid air conditions and high airflow rate. The visible-light-activity of TiO2 thin films was tested with 5 ppm MTBE and acetone. TiO2 thin films deposited at 350 °C with a surface area of 600 cm2 showed 60% of MTBE and 33% of acetone degradation under VIS light.

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Lou, J. S., and J. Jankovic. "Essential tremor: Clinical correlates in 350 patients." Neurology 41, no. 2, Part 1 (1991): 234. http://dx.doi.org/10.1212/wnl.41.2_part_1.234.

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Saleh, Saleh S., and Hasan Zuhudi Abdullah. "Optimization and Characterization of Anatase Formed on Anodized Titanium in Phosphoric Acid." Materials Science Forum 840 (January 2016): 240–44. http://dx.doi.org/10.4028/www.scientific.net/msf.840.240.

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Titanium (Ti) is widely used in dental and orthopedic implants because of its good biocombatibility and high corrosion resistance. Titanium oxide (TiO2) has shown to exhibit strong physicochemical bonding between Ti implant and living bone because of its ability to induce bone-like apatite in a body environment. Ti is always coated by an oxide surface layer of 1.5-10 nm thickness. TiO2 crystalline structures; anatase and rutile present several distinctive features, such as photocatalytic behaviour, superhydrophilicity and biocompatible properties. Anodic oxidation is used to modify the surface of pure titanium in a phosphuric acid electrolyte in order to maximize and characterize the TiO2 anatase crystalline phase. In the present work, thick films of the anatase polymorph of TiO2 were formed on commercially pure Ti foil under potentials 200 V-350 V at current densities 40 and 60 mA/cm2 for 10 min. Multiple characterization techniques were used. Glancing angle X-ray diffraction (GAXRD) is used to obtain crystalline phases, field emission scanning electron microscope (FESEM) is used to obtain surface images and water contact angle (WCA) is used to obtain the wettability of the oxide surface. According to GAXRD results the intensity of the major peak increased with increasing applied voltage and current density while decrease with molar concentration. This means that the amount and/or crystallinity of anatase are/is influenced with these parameters. The coated oxides obtained small amount of anatase is comparing to films anodized in H2SO4 electrolyte. Which confirm that slower crystallization in H3PO4 than in H2SO4. FESEM images obtained that as the voltage increased, the film breaks down locally and results in a porous surface. The porosity and the pore size increase with the increasing voltage. The pore size diameter at 300V for 0.3 M can reach up to 1μm. As for WCA results the coated samples at higher voltages (250 V, 300 V and 350 V) and molar concentration 0.3 M have shown more hydrophilic surface, with sample anodized at 350 V at 0.3 M have the lowest contact angle, thus the highest surface energy. While samples anodized at 200 V voltage observed more hydrophobic surface with sample anodized at 200 V at 0.1 M have the lower wettability, thus the lowest surface energy.

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Troccoli, Alberto. "Climate and the development community." Weather 64, no. 1 (2009): 25–26. http://dx.doi.org/10.1002/wea.350.

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Aithal, Sreedevi, Venkatesh Aithal, Joseph Kei, and Alehandrea Manuel. "Effect of Negative Middle Ear Pressure and Compensated Pressure on Wideband Absorbance and Otoacoustic Emissions in Children." Journal of Speech, Language, and Hearing Research 62, no. 9 (2019): 3516–30. http://dx.doi.org/10.1044/2019_jslhr-h-18-0426.

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Objective This study investigated pressurized transient evoked otoacoustic emission (TEOAE) responses and wideband absorbance (WBA) in healthy ears and ears with negative middle ear pressure (NMEP). Method In this cross-sectional study, TEOAE amplitude, signal-to-noise ratio, and WBA were measured at ambient and tympanometric peak pressure (TPP) in 36 ears from 25 subjects with healthy ears (age range: 3.1–13.0 years) and 88 ears from 76 patients with NMEP (age range: 2.0–13.1 years), divided into 3 groups based on NMEP (Group 1 with TPP between −101 and −200 daPa, Group 2 with TPP between −201 and −300 daPa, and Group 3 with TPP between −301 and −400 daPa). Results Mean TEOAE amplitude, signal-to-noise ratio, and WBA were increased at TPP relative to that measured at ambient pressure between 0.8 and 1.5 kHz. Further decrease in TPP beyond −300 daPa did not result in further increases in the mean TEOAE or WBA at TPP. The correlation between TEOAE and WBA was dependent on the frequency, pressure conditions, and subject group. There was no difference in pass rates between the 2 pressure conditions for the control group, while the 3 NMEP groups demonstrated an improvement in pass rates at TPP. With pressurization, the false alarm rate for TEOAE due to NMEP was reduced by 17.8% for NMEP Group 1, 29.2% for NMEP Group 2, and 15.8% for NMEP Group 3. Conclusion Results demonstrated the feasibility and clinical benefits of measuring TEOAE and WBA under pressurized conditions. Pressurized TEOAE and WBA should be used for assessment of ears with NMEP in hearing screening programs to reduce false alarm rates.

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Spectre, Galia, Lisa Arnetz, Claes-Göran Östenson, Kerstin Brismar, Nailin Li, and Paul Hjemdahl. "Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications." Thrombosis and Haemostasis 106, no. 09 (2011): 491–99. http://dx.doi.org/10.1160/th11-04-0216.

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SummaryThe efficacy of low-dose aspirin in type 2 diabetes mellitus (T2DM) has been questioned. We tested if twice daily dosing of aspirin would be more effective in T2DM, possibly due to increased platelet turnover. A randomised cross-over study compared 75 mg aspirin OD, 75 mg BID and 320 mg OD (≥2 week treatment periods) in 25 patients with T2DM and micro- or macrovascular complications. Platelet responses were examined by impedance aggregometry (WBA) and the IMPACT-R aspirin test in whole blood, light transmittance aggregometry in plateletrich plasma (LTA), and urinary 11-dehydro-thromboxane B2 (TxM). Aspirin 75 mg BID decreased arachidonic acid (AA)-induced WBA compared to 75 mg OD (9.7 ± 4.5 vs. 12.6 ± 3.5 ohm; p=0.003) or to 320 mg OD (11.5 ± 4.2 Ohms; p=0.049). WBA responses to collagen were similarly attenuated by BID or high dosing (by 12–14%; p=0.02 for both). The IMPACT-R showed a better response to 75 mg BID compared to 75 mg OD (p=0.049), but not to 320 mg OD. AA-induced aggregation by LTA was <6.5% on all occasions, with no differences between aspirin dosages. TxM was reduced after 320 mg OD (p=0.002), but not 75 mg BID (p=0.07). Reticulated platelets were highly correlated with mean platelet volume (MPV; r2=0.74, p<0.0001). Both markers for platelet turnover were correlated with AA-induced WBA, but neither identified patients who benefited from BID dosing dependably. In conclusion, twice daily dosing improved laboratory responses to aspirin in high risk T2DM patients. Studies of whether BID dosing of aspirin can improve clinical outcomes in such patients are of interest.

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Yang, Yu Sen, Ting Pin Cho, and Jia Hau Lin. "Annealing Effects on Hydrophobic AlN Coatings." Applied Mechanics and Materials 284-287 (January 2013): 276–80. http://dx.doi.org/10.4028/www.scientific.net/amm.284-287.276.

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The effects of annealing at various annealing temperature on hydrophobic AlN coatings were investigated. AlN coatings were deposited in Ar/N2 plasma by using reactive magnetron sputtering process. Two medium frequency (MF) powered Al targets were used. AlN coatings were annealed in air at 300°C, 600°C, 700°C, 800°C, 900°C, 1000°C and 1100°C, respectively. The hydrophobic and hydrophilic properties were evaluated by using water contact angle (WCA) measurement. Microstructure and morphology were observed using X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray Photoelectron Spectrometer (XPS), respectively. According to the results revealed by XRD and SEM, AlN possess hexagonal close-packed (hcp) structures and good crystallization. The morphology of AlN coating after annealing at 800°C is still similar to the as-deposited AlN coating. As the annealing temperature increases to 1000°C, the XRD peaks of Al2O3 phase can be clearly identified. The main XRD peaks of the AlN coatings still can be found after annealing at 1100°C. The as-deposited AlN coating exhibits hydrophobic behavior and the highest WCA of 119°. As the annealing temperature increases to 300°C, the WCA decreases sharply to 77°. The lower WCA of AlN coatings obtained after annealing is related to the Al2O3 thin films upon AlN coatings.

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Ambrose, Christopher S., Xiaohui Jiang, and Kunjana Mavunda. "737. The Prevalence of Diagnosed Chronic Lung Disease in US Infants by Gestational Age: Implications for RSV Policy." Open Forum Infectious Diseases 5, suppl_1 (2018): S264—S265. http://dx.doi.org/10.1093/ofid/ofy210.744.

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Abstract Background Perinatal chronic lung disease (CLD), previously referred to as bronchopulmonary dysplasia (BPD), is associated with preterm birth and occurs rarely among term infants. Children with CLD are at elevated risk for severe RSV disease in the first 2 years of life. Definitions of CLD/BPD identify infants who require supplemental oxygen at 28 days of life or 36 weeks postmenstrual age, with no restriction by gestational age (GA) at birth. However, the AAP Committee on Infectious Disease guidance does not recommend RSV immunoprophylaxis for infants with CLD born at ≥32 weeks gestational age (wGA), even though infants with CLD/BPD up to 41 wGA were included in pivotal efficacy studies. This study determined the prevalence of diagnosed CLD in US infants as a function of wGA at birth and the number of infants with CLD born at ≥32 wGA. Methods The Kids’ Inpatient Database (KID) is a nationally representative survey conducted every 3 years in the United States. Birth hospitalization data from KID were utilized to estimate the prevalence of CLD (ICD-9 = 770.7) among US infants in 2003–2012 overall and as a function of coincident codes for GA (ICD-9 = 765.21–765.29, reported in 2-week intervals). The prevalence of CLD among 32 wGA infants was imputed based on the distribution of CLD cases as a function of wGA. KID data from 2015 were not available due to the transition to ICD-10 coding. Results A total of 31,984 infants had a CLD diagnosis across the 4 years, representing 0.2% of US births. The prevalence of CLD declined from 20.8 to 19.5 per 10,000 between 2003 and 2012. Of those, 25,554 infants with CLD (80%) had GA coded in the database. The percentage of CLD infants born at &lt;27 wGA increased from 44% in 2003 to 52% in 2012, whereas the percentage at ≥29 wGA decreased from 27% to 21% (figure). Overall, the percentages born at 31–32, 33–34, and &gt;34 wGA were 5.7%, 2.2%, and 1.2%, respectively. An estimated 5.7% of infants with CLD were born at ≥32 wGA, representing 0.9 of every 10,000 US births or ~350 infants annually. Conclusion Fewer than 400 infants are born at ≥32 wGA and diagnosed with CLD annually in the United States. The rationale for excluding this small but high-risk group of infants from the population recommended for RSV immunoprophylaxis is not clear. Funded by AstraZeneca :Disclosures. C. S. Ambrose, AstraZeneca: Employee, Salary and Stocks. X. Jiang, EpiStat Institute: Employee, Consulting fee and Salary. AstraZeneca: Consultant, Consulting fee. K. Mavunda, AstraZeneca: Speaker’s Bureau, Speaker honorarium.

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Anshar, Andi Muhammad, Sengo Kobayashi, and Satoshi Okano. "Effect of Heat Treatments on Wettability of Nacre." Materials Science Forum 985 (April 2020): 86–90. http://dx.doi.org/10.4028/www.scientific.net/msf.985.86.

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The surface wettability of biomaterials influences on osteoblast behavior and bone formation. In this research, the variation of wettability of nacre by heat treatments was examined. Plates of the nacre were fabricated from shells of the Akoya pearl oyster. The specimens were heated at 100, 200, 300, 400, 500, and 600 °C. Characterizations of the specimens during and after heat treatments were carried out using scanning electron microscopy, X-ray diffractometry, and thermogravimetry-differential thermal analysis. The water contact angle (WCA) of the specimen was measured to evaluate wettability. The color of nacre changed from iridescent color to brownish weak-iridescence by the heating at and over 300 °C. The nacre heated at and over 300 °C became brittle because organic substances in nacre, which acts as the glue between the aragonite platelets were evaporated by the heating. The WCA of the specimen was decreased with increasing heating temperature, which should be related to the decrease in the number of organic substances in nacre by the heating.

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Byker, Holly P., Nader Soltani, Darren E. Robinson, François J. Tardif, Mark B. Lawton, and Peter H. Sikkema. "Control of glyphosate-resistant Canada fleabane [Conyza canadensis (L.) Cronq.] with preplant herbicide tankmixes in soybean [Glycine max. (L). Merr.]." Canadian Journal of Plant Science 93, no. 4 (2013): 659–67. http://dx.doi.org/10.4141/cjps2012-320.

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Byker, H. P., Soltani, N., Robinson, D. E., Tardif, F. J., Lawton, M. B. and Sikkema, P. H. 2013. Control of glyphosate-resistant Canada fleabane [ Conyza canadensis (L.) Cronq.] with preplant herbicide tankmixes in soybean [ Glycine max . (L). Merr.]. Can. J. Plant Sci. 93: 659–667. Glyphosate previously provided excellent control of Canada fleabane; however, with the evolution of glyphosate-resistant (GR) Canada fleabane in Ontario, alternative herbicides must be identified for control of this weed in soybean. The objective of this study was to identify preplant herbicide tankmixes that provide effective control of GR Canada fleabane. A total of 12 field trials were completed over a 2-yr period (2011, 2012) in fields previously confirmed with GR Canada fleabane. Preplant tankmixes of glyphosate (900 g a.e. ha−1) plus saflufenacil (25 g a.i. ha−1) or saflufenacil/dimethenamid-p (245 g a.i. ha−1) provided greater than 87% control 4 wk after application (WAA) across all sites. Glyphosate (900 g a.e. ha−1) tankmixed with metribuzin (1120 g a.i. ha−1), cloransulam-methyl (35 g a.i. ha−1) or flumetsulam (70 g a.i. ha−1) provided 78 to 99% control 8 WAA. Control of GR Canada fleabane prior to soybean emergence is essential as currently there are no herbicides that provide acceptable control in-crop. Because of the lack of in-crop options, spring residual herbicides may be required for season long control in regions where Canada fleabane emerges throughout the year to reduce Canada fleabane seed production and populations in subsequent years.

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Yousefian, Zeynab, Behnaz Hosseini, Hassan Rezadoost, Javier Palazón, and Mohammad Hossein Mirjalili. "Production of the Anticancer Compound Withaferin A from Genetically Transformed Hairy Root Cultures of Withania Somnifera." Natural Product Communications 13, no. 8 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300806.

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Withanolides (WTDs), well-known medicinally important compounds of Withania somnifera, including the anticancer compound withaferin A (WFA), are biosynthesized from their dedicated precursor squalene. Condensation of farnesyl pyrophosphate (FPP) molecules to produce squalene is catalyzed by squalene synthase (SQS). In the present study, the Arabidopsis thaliana squalene synthase gene ( AtSQS1) was transformed in W. somnifera by Agrobacterium tumefaciens C58C1 (pRiA4). The AtSQS1 gene was detected in 87.88 % of induced transformed hairy roots (THRs). The results showed that the growth index (GI) of THRs after five weeks of culture was 2-fold higher than that of adventitious hairy roots (AHRs). The biomass doubling time of THRs and AHRs was 18 and 30 days, respectively. Quantitative evaluation of WFA in the studied roots showed that THRs contain 1.51-fold more WFA (330±0.87μg g−1 dry weight (DW)) than AHRs (218±0.17μg g−1 DW). These findings can be used for the production of WFA as a valuable anticancer compound through controlled and scaled up cultures of W. somnifera THRs.

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Tuan, T. L., and F. Grinnell. "Wheat-germ-agglutinin and Ricinus communis-agglutinin-binding sites of BHK cells compared with each other and with 140 kDa fibronectin receptors." Biochemical Journal 251, no. 1 (1988): 269–77. http://dx.doi.org/10.1042/bj2510269.

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We compared the wheat-germ agglutinin (WGA) and Ricinus communis agglutinin (RCA) binding sites of baby-hamster kidney (BHK) cells. There were 1.01 × 10(8) WGA-binding sites per cell (Kd = 0.027 nM) and 6 × 10(6) RCA-binding sites per cell (Kd = 0.014 nM). Binding of WGA or RCA to BHK cells resulted in more than 75% of the cell-surface binding sites becoming associated with the cytoskeleton (i.e. resistant to extraction with detergent), although no more than 10% of these sites were associated with the cytoskeleton before addition of the lectins. After binding of WGA to the cells, the cell surface was cross-linked so extensively that it remained intact even after detergent extraction of the treated cells, and could be observed by electron microscopy. A similar cross-linking effect did not occur after binding of RCA to cells, which may be because there were so many more binding sites for WGA than for RCA. The composition of WGA- and RCA-binding molecules was analysed by lectin affinity chromatography of metabolically radiolabelled BHK cells. We found that in the WGA-binding-molecule preparations there were eight major polypeptides, ranging in molecular mass from 93 to 340 kDa, and that the RCA-binding molecules were a subpopulation of the WGA-binding molecules. A polyclonal antibody against the 140 kDa fibronectin (FN) receptors of Chinese-hamster ovary (CHO) cells immunoblotted a 145 kDa polypeptide component in both WGA- and RCA-binding-molecule preparations. The results indicated that the 145 kDa component was present in at least two FN-receptor complexes that differed in glycosylation, only one of which was able to bind to RCA affinity columns. The oligomeric nature of the FN-receptor complex, which contained three polypeptides with molecular masses of 120-145 kDa, was demonstrated by using anti-(CHO-cell FN receptor) antibodies to immunoprecipitate extracts prepared from radioiodinated BHK cells.

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Mayer, Alice, Michele Rienzner, Sandra Cesari de Maria, Marco Romani, Alberto Lasagna, and Arianna Facchi. "Correction: Mayer, A., et al. A Comprehensive Modelling Approach to Assess Water Use Efficiencies of Different Irrigation Management Options in Rice Irrigation Districts of Northern Italy. Water 2019, 11, 1833." Water 12, no. 4 (2020): 1047. http://dx.doi.org/10.3390/w12041047.

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In the published article [1] the authors noticed an error in the ‘Percolation or Capillary Rise’ values reported in Table 4, column 4, and wish to make the following correction to their paper [1]: Table 4 should be replaced with the following: Actual Evapotranspiration (mm) Irrigation (mm) Percolation (−) or Capillary Rise (+) (mm) WUE (%) Maize 449 620 (438, 705) −589 (−243, −732) 50 (61, 44) Irrigated poplar 348 300 (300, 300) −247 (−215, −252) 57 (50, 58) Rainfed poplar 487 0 −18 (+232, −57) 159 (149, 159) WDA rice 537 1394 (964, 1620) −1002 (−491, −1206) 34 (43, 29) WFL rice 592 1852 (1508, 2210) −1266 (−860, −1693) 28 (32, 23) [...]

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Qin, Yong Chun, Sui Yuan Wang, Wei Zeng, Xiao Pei Shi, Jian Xu, and Song Chang Huang. "The Effect of Asphalt Binder Aging on Fatigue Performance of Evotherm WMA." Advanced Materials Research 535-537 (June 2012): 1686–92. http://dx.doi.org/10.4028/www.scientific.net/amr.535-537.1686.

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One of the main benefits advertised with the use of warm mix asphalt (WMA) is the decreasing aging of the asphalt binder resulting from the lower production temperature compared to conventional hot mix asphalt (HMA). Some tests were performed to determine the asphalt binder aging properties from WMA and HMA. Asphalt binders were recovered by extraction and distillation from asphalt mixtures premixed at different temperatures (140°C, 160°C, 180°C for HMA, 100°C and 120°C for WMA) in the mixing plant. Penetration@25°C, softening point (R&B) and rotational Brookfield viscosity tests were carried out. Results show that the aging of asphalt binder increases as the mixing temperature is elevated, and remarkably accelerates at the temperatures higher than 150°C. Warm mix asphalt (for example, mixing temperature at 100°Cor 120°C) can greatly reduce the aging of asphalt. Aging of the asphalt binder is one of the factors that would affect the mixture’s fatigue life. Four-point beam fatigue test samples were mixed and compacted at 140°C for HMA and 120°C for WMA, and fatigue tests with a frequency of 10 Hz and three constant strain levels (150 micro-strain, 300 micro-strain, 450 micro-strain, respectively) were performed. Results show that WMA’s fatigue life was higher than the control HMA, which indicates that it may reduce aging of asphalt binder and improve fatigue performance of asphalt mixture at lower production temperatures.

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Burt, Stephen. "London's highest barometric pressure in over 300 years." Weather 75, no. 4 (2020): 109–16. http://dx.doi.org/10.1002/wea.3688.

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Figueroa, Rodrigo, Douglas Doohan, and John Cardina. "Efficacy and Selectivity of Promising Herbicides for Common Groundsel Control in Newly Established Strawberry." HortTechnology 15, no. 2 (2005): 261–66. http://dx.doi.org/10.21273/horttech.15.2.0261.

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Common groundsel (Senecio vulgaris) is an increasingly important weed in strawberries (Fragaria ×ananassa), a crop in which open space within and between rows is susceptible to infestations. Cultivation, hand hoeing, and registered herbicide are only partially effective in controlling common groundsel, and tolerance or resistance to herbicides is common in this species. Field and greenhouse studies were conducted to identify and select herbicides for controlling common groundsel in newly planted strawberries. Herbicides applied to strawberries within 1 week after planting in 2000 were: terbacil and simazine alone and tank mixed with napropamide; pendimethalin, dimethenamid, metolachlor, ethofumesate and sulfentrazone. Based on selectivity and efficacy observed in this preliminary experiment, sulfentrazone and flumiclorac were selected for further evaluation in 2001 and 2002. Strawberry tolerance of sulfentrazone and flumiclorac 1, 3, 6, and 18 weeks after application (WAA) was similar to that of the registered herbicides terbacil and napropamide, but injury was greater than in hand weeded plots. Plants sprayed with 300 g·ha–1 (4.3 oz/acre) sulfentrazone produced yields similar to terbacil treated plants, but with less plant stunting. Tolerance of newly planted `Allstar' and `Jewel' was affected by the interaction of soil pH and sulfentrazone rate. Plant stunting 3 WAA increased with sulfentrazone rate, reaching 68 and 61% in `Allstar' and `Jewel', respectively, with the highest rate [400 g·ha–1 (5.7 oz/acre)] and high soil pH (7). `Allstar' grown in low pH (5) and treated with sulfentrazone (400 g·ha–1) showed only 8% stunting, whereas `Jewel' was not stunted 3 WAA at the same rate and pH. Both cultivars recovered (50% less stunting) from the severe injury observed when sulfentrazone was applied to high pH soils. However, at low pH both cultivars were stunted more at 6 WAA than at 3 WAA. Plant diameter for both cultivars was 25% higher when they were grown in the lower soil pH. Fruit yield was not affected by the sulfentrazone rates evaluated (0 to 400 g·ha–1). Sulfentrazone was active at four stages of common groundsel growth: preemergence (PRE), cotyledon (COT), early post (EPOST) seedlings at the four-leaf stage, and late post (LPOST) seedlings at the10-leaf stage. The calculated 50% growth reduction (GR50) value for PRE and COT stages was 50 g·ha–1 (0.7 oz/acre), whereas the GR50 for EPOST and LPOST stages was 100 g·ha–1 (1.4 oz/acre). Sulfentrazone controlled common groundsel when applied PRE and COT, but at EPOST and LPOST stages sulfentrazone did not provide complete control, although plant height was reduced 80% to 90% compared to untreated plants. Results indicated that common groundsel is controlled in the field with 150 and 300 g·ha–1 (2.1 and 4.3 oz/acre) of sulfentrazone applied before seedling emergence. The least strawberry injury occurred when sulfentrazone was applied immediately after transplanting at 150 and 300 g·ha–1, although crop tolerance was reduced under conditions of high soil pH (>6.5) and varied with cultivar.

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White, Robin E., and Rona G. Giffard. "MicroRNA-320 induces neurite outgrowth by targeting ARPP-1." NeuroReport 23, no. 10 (2012): 590–95. http://dx.doi.org/10.1097/wnr.0b013e3283540394.

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Polisseni, J., M. A. Machado, A. L. Souza, et al. "266 WHOLE GENOME AMPLIFICATION ON BLASTOMERS OF POST-BIOPSY BOVINE EMBRYO." Reproduction, Fertility and Development 21, no. 1 (2009): 230. http://dx.doi.org/10.1071/rdv21n1ab266.

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Biopsy of embryos is very useful for choosing the desired sex and for production of cloned and transgenic livestock. However, only a small amount of genomic DNA is available to perform genetic studies. Alternatively, methodologies using whole genome amplification (WGA) have been developed. The aims of this study were to evaluate the effect of WGA on blastomeres removed from 8- to 16-cell bovine embryos and to determine the sex of blastomeres. Oocytes obtained from slaughterhouse ovaries were in vitro matured and fertilized. On the fourth day after fertilization, 8- to 16-cell bovine embryos were biopsied, and one-fourth of an embryo was removed. The blastomeres (n = 56) were submitted to WGA followed by PCR. Prior to the whole genome amplification, male and female bovine DNA samples were serially diluted (30 ng μL–1, 3.0 ng μL–1, 0.3 ng μL–1, 0.03 ng μL–1, 0.003 ng μL–1, 0.0003 ng μL–1) and embryos of various development stages (2, n = 6; 4–7, n = 5; ≥8-cell, n = 5; blastocyst n = 27) were used to standardize PCR protocols and set the amplification limits. To digest the cellular cytoplasm and release the genomic DNA, embryos and blastomeres were submitted a 3 mg mL–1 proteinase K before PCR. Next, blastomeres were submitted to the GenomiPhi DNA Amplification Kit (GE Healthcare) according to manufacturer’s instructions. The product (1 μL) was electrophoresed on a 1% agarose gel stained with 3.0 μg mL–1 ethidium bromide. The reaction mixture was added to the material to be amplified (2 mm MgCl2, 5X PCR buffer, 0.2 mm each dNTPs, 0.05 U μL–1 GoTaq DNA polymerase, 0.25 μm of primer). The products were submitted to electrophoresis on 8% polyacrilamide gel and stained with silver nitrate procedure. The chi-square test was used for statistic evaluation of the results to test the WGA efficiency and to determine the sex rates of bovine embryos and biopsied samples submitted to PCR. It was possible to achieve 98% efficiency in amplifying blastomeres using the WGA kit. Amplified samples showed approximately 400 ng of DNA generated from an estimated initial amount of 12 pg of DNA resulting from two cells per embryo. In whole embryos from different stages, no diffference was detected in the proportion of sexes (P > 0.05). However, a greater number of female samples was noted in biopsied material (76%, 25/33) (P < 0.05). PCR efficiency in blastocysts (93%, 2/27) was statistically greater (P < 0.05) than embryos in early stages of development (83%, 5/6), and biopsied material to 2, 4–7 and ≥8-cell (40%, 2/5; 60%, 3/5; and 59%, 33/56; respectively). These differences could be related to a sex-chromosomal mosaicism or absence of a nucleus in biopsied samples. The WGA creates a DNA stock sample that could be used for various gene profiling and sex determination analyses. Financial support: Fapemig, CNPq.

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Watson, Crystal, Hairong Xu, Anna Forsythe, Shan Ashton Garib, and Arie Barlev. "Younger Patients Are Impacted By Post-Transplant Lymphoproliferative Disorder: Findings from a Systematic Literature Review of Real-World Evidence." Blood 132, Supplement 1 (2018): 5841. http://dx.doi.org/10.1182/blood-2018-99-113622.

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Abstract Introduction: Transplant recipients younger than 18 years old are believed to have a 2- to 4-fold higher risk of developing post-transplant lymphoproliferative disorder (PTLD) than adult transplant patients. Within the pediatric group, there is evidence to suggest an increased risk of PTLD in younger children. We conducted a systematic literature review (SLR) to estimate the weighted mean age (WMA) at PTLD diagnosis and describe patient demographics in the real-world setting. Methods: An SLR was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines with the scope defined in terms of Population, Intervention Comparators, Outcomes, and Study design (PICOS) criteria. Studies were identified based on a systematic search using key biomedical literature databases: EMBASE, MEDLINE, and Cochrane. The literature search was conducted on July 19, 2018 and included studies published between database inception in January 1, 1959 and July 19, 2018. Relevant congress abstracts published between January 2015 and June 2018 were also identified. The PICOS-based inclusion and exclusion criteria were used to review identified citations. To ensure inclusion of all relevant evidence, no treatment limitations were imposed; however, the study designs were limited to prospective and retrospective observational studies. Case reports were included regardless of sample size. Two independent reviewers screened all citations and full-text articles; any discrepancies were resolved by a third independent reviewer. Data from included studies were extracted into a pre-defined template, and results were summarized using the PRISMA flow diagram. Using the sample size from the selected studies, the WMA for each relevant subgroup was determined and was compared to the average age at the time of diagnosis for other cancers reported in SEER Cancer Statistics (2011-2015; https://seer.cancer.gov/csr/). Results: A total of 447 studies fulfilled the search criteria: 114 adult studies, 136 pediatric studies with varied definitions (< 16, < 18 or < 21 years old), and 197 that did not specify inclusion by age. Seventy studies enrolled only PTLD patients after allogeneic hematopoietic stem cell transplantation (HCT). Among these studies, 17 included pediatric patients with a WMA of 12.5 years, 10 included adult patients with a WMA of 40.2 years, and 41 had no age restriction with a WMA of 34.4 years. For pediatric patients, the risk of post-HCT PTLD was 1.3-23.5% and the time from transplant to PTLD was 0.9-6.0 months. There was only one pediatric HCT study (N=4; mean age, 9 years), which reported median survival of 27.6 months. A total of 350 studies only enrolled PTLD patients after solid-organ transplant (SOT). Among these studies, 115 included pediatric patients with a WMA of 6.6 years, 98 included adult patients with a WMA of 46.9 years, and 136 had no age restriction with a WMA of 38.6 years. Among the pediatric SOT studies, the risk of PTLD was 0.3-25.0%, the time from transplant to PTLD was 1.4-92.8 months, and the reported survival was 0.9-37.2 months. The average age of lymphoma patients at cancer diagnosis according to the SEER Cancer Statistics database was 65 years. Conclusions: This SLR of published real-world studies demonstrates that the WMA at PTLD diagnosis (for studies with no age restrictions: 34.4 years for HCT and 38.6 years for SOT) is substantially lower than the reported average age at diagnosis for lymphomas (65 years), irrespective of study design and inclusion criteria. PTLD greatly impacts the pediatric population, with a quarter of HCT studies and a third of SOT studies focusing on this population. Currently, there is no indicated treatment for this ultra-rare disease with poor prognosis, indicating a clear unmet need for patients with PTLD that disproportionately affects younger patients. Disclosures Watson: Atara Biotherapeutics, Inc: Employment, Equity Ownership. Xu:Atara Biotherapeutics, Inc: Employment, Equity Ownership. Forsythe:Novartis: Consultancy. Barlev:Atara Biotherapeutics, Inc: Employment, Equity Ownership.

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Barros Asenjo, Santiago, and Patricio Rojas Vergara. "Ensayos de procedencias de Eucalyptus camaldulensis Dehnh en la zona semiárida de Chile." Ciencia & Investigación Forestal 1, no. 1 (1987): 29–40. http://dx.doi.org/10.52904/0718-4646.1987.21.

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En 1984 se instalaron cuatro ensayos de procedencias de Eucalyptus camaldulensis Dehnh en la zona central de Chile (32º a 34º lat S), donde la precipitación media anual varía entre 300 y 700 mm. La semilla, obtenida de CSIRO-Australia, correspondía a 14 procedencias, entre las cuales se incluían las más sobresalientes del clima tropical, Katherine, N.T. y Pedford, QLD, del clima mediterráneo, Lake Albacutya, Vic., y del clima árido, Nueva Gales del Sur. A los dos años, en las cuatro localidades ensayadas, la procedencia de mayor plasticidad en términos de supervivencia, crecimiento, forma y productividad fue Lake Albacutya, Vic.(10666). En el mejor sitio su altura promedio a esa misma edad fue de 2,13 m con un crecimiento medio anual en altura de 1,12 m. Las procedencias de menor crecimiento en todos los lugares de ensayo fueron: Agnew, W.A.(9856); NW Dodnadatta, S.A.(12828); N. de Quilpio, QLD (13264) y Fitzroy River Crossiana, W.A.(13250)

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Aprianto, Dian, Christine Wulandari, and Niskan Walid Masruri. "Karbon Tersimpan Pada Kawasan Sistem Agroforestry Di Register 39 Datar Setuju Kphl Batutegi Kabupaten Tanggamus." Jurnal Sylva Lestari 4, no. 1 (2016): 21. http://dx.doi.org/10.23960/jsl1421-30.

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Datar Setuju Resort is the one of six resort located in Register 39 KPHL Batutegi. This area is managed by implementing agroforestry system Research aims to determine amount of stock carbon applied by publics in Register 39 Datar Setuju, held on March 2015 at Register 39 Datar Setuju KPHL Batutegi Tanggamus Regency. Beside to knowing amount of the stock carbon, this research also conducted to determine the dominant vegetation. Reseachers used Summed Dominance Ratio (SDR) and Importance Value Index (IVI) methods to determine the most dominant vegetations and used allometric equation to find out amount biomass and necromass of trees. Research results show that the most dominant vegetation on tree phase was cemara (Casuarina junghuniana) IVI large was 109,91%, for pale phase was dadap (Erythrina sp.) IVI large was 300%, for stake phase was kopi (Coffea arabica) IVI large was 300%, and for seedling phase was rumput teki (Cyperus rotundus) IVI large was 200%. Stock carbons at agroforestry system area Register 39 Datar Setuju KPHL Batutegi on HKm Sinar Harapan amount of 123,33 ton/ha, on HKm Bina Wana Jaya 1 amount of 265,20 ton/ha, and of HKm Bina Wana Jaya 2 amount of 146,20 ton/ha, average of stock carbon value at Register 39 Datar Setuju amount of 178,24 ton/ha. Key words: stock carbon, agroforestry

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Underwood, Matthew G., Nader Soltani, David C. Hooker, et al. "The Addition of Dicamba to POST Applications of Quizalofop-p-ethyl or Clethodim Antagonizes Volunteer Glyphosate-Resistant Corn Control in Dicamba-Resistant Soybean." Weed Technology 30, no. 3 (2016): 639–47. http://dx.doi.org/10.1614/wt-d-16-00016.1.

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Two studies consisting of six field experiments each were conducted at three locations in southwestern Ontario, Canada, in 2014 and 2015 to evaluate the possible antagonism when dicamba was added to quizalofop-p-ethyl or clethodim for the control of volunteer glyphosate-resistant (GR) corn. At 4 wk after application (WAA), quizalofop-p-ethyl at 24, 30, or 36 g ai ha−1provided 88, 94, and 95% control of volunteer GR corn, respectively. The addition of dicamba at 300 or 600 g ae ha−1to quizalofop-p-ethyl (24 g ha−1) reduced the activity of quizalofop-p-ethyl on volunteer GR corn by 12 and 20%. At 4 WAA, clethodim at 30, 37.5, and 45 g ai ha−1provided 85, 91, and 95% control of volunteer GR corn, respectively. The addition of dicamba at 300 or 600 g ha−1to clethodim (30 g ha−1) resulted in antagonism, causing a reduction in volunteer GR corn by 12 and 11%, respectively. In general, there was greater antagonism when the high rate of dicamba was tank-mixed with the lower rate of the graminicide. There was no antagonistic effect on soybean yield by tank-mixing dicamba with either graminicide at all rates evaluated. Based on these results, volunteer GR corn can be controlled effectively by increasing the rate of the graminicide when tankmixed with dicamba.

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Briscoe, Charles. "Summer rainfall trends." Weather 63, no. 10 (2008): 318–19. http://dx.doi.org/10.1002/wea.300.

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Marsh, Terry. "A hydrological overview of the summer 2007 floods in England and Wales." Weather 63, no. 9 (2008): 274–79. http://dx.doi.org/10.1002/wea.305.

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Busby, Simon J. "Simulating multiyear drought events in North America with the HadCM3 climate model." Weather 63, no. 8 (2008): 240–43. http://dx.doi.org/10.1002/wea.310.

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Kennedy, John, Holly Titchner, David Parker, Mark Beswick, Jen Hardwick, and Peter Thorne. "Global and regional climate in 2007." Weather 63, no. 10 (2008): 296–304. http://dx.doi.org/10.1002/wea.320.

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Burt, Stephen. "Reply from Stephen Burt." Weather 63, no. 10 (2008): 317–18. http://dx.doi.org/10.1002/wea.330.

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Prichard, R. E. "Distribution ofWeatherfrom Singapore." Weather 63, no. 10 (2008): 319. http://dx.doi.org/10.1002/wea.340.

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McMahon, Barry B. "Measuring winds from space: the European Space Agency's Aeolus mission." Weather 74, no. 9 (2019): 312–15. http://dx.doi.org/10.1002/wea.3500.

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Pike, W. S., Stephen Bartholomew, and Malcolm Wickenden. "Weather diaries during the easterlies of February and March 2018." Weather 74, no. 4 (2019): 130–32. http://dx.doi.org/10.1002/wea.3502.

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Galvin, Jim. "In this issue of Weather." Weather 74, no. 4 (2019): E1. http://dx.doi.org/10.1002/wea.3507.

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Denyer, Graham. "Where the Wild Winds are – Walking Europe's Winds from the Pennines to Provence." Weather 74, no. 9 (2019): 327. http://dx.doi.org/10.1002/wea.3508.

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Furger, Markus. "Cloud-base or mountain shadow?" Weather 64, no. 2 (2009): 53. http://dx.doi.org/10.1002/wea.352.

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Tartaglione, Nazario. "The sun pillar of 26 May 2018 at Bergen." Weather 75, no. 1 (2019): 14–15. http://dx.doi.org/10.1002/wea.3520.

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Galvin, Jim. "Two cases of turbulence over western Europe." Weather 64, no. 3 (2009): 83–84. http://dx.doi.org/10.1002/wea.353.

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Rodda, Harvey J. E., Max A. Little, Rose G. Wood, Nina MacDougall, and Patrick E. McSharry. "A digital archive of extreme rainfalls in the British Isles from 1866 to 1968 based onBritish Rainfall." Weather 64, no. 3 (2009): 71–75. http://dx.doi.org/10.1002/wea.354.

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Eden, Philip. "October 2008 Changeable; warm second week, but exceptional wintry snap towards the end." Weather 63, no. 12 (2008): i—iv. http://dx.doi.org/10.1002/wea.355.

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Dao, Dong Van, Ngoc-Lan Nguyen, Hai-Bang Ly, Binh Thai Pham, and Tien-Thinh Le. "Cost-Effective Approaches Based on Machine Learning to Predict Dynamic Modulus of Warm Mix Asphalt with High Reclaimed Asphalt Pavement." Materials 13, no. 15 (2020): 3272. http://dx.doi.org/10.3390/ma13153272.

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Warm mix asphalt (WMA) technology, taking advantage of reclaimed asphalt pavements, has gained increasing attention from the scientific community. The determination of technical specifications of such a type of asphalt concrete is crucial for pavement design, in which the asphalt concrete dynamic modulus (E*) of elasticity is amongst the most critical parameters. However, the latter could only be determined by complicated, costly, and time-consuming experiments. This paper presents an alternative cost-effective approach to determine the dynamic elastic modulus (E*) of WMA based on various machine learning-based algorithms, namely the artificial neural network (ANN), support vector machine (SVM), Gaussian process regression (GPR), and ensemble boosted trees (Boosted). For this, a total of 300 samples were fabricated by warm mix asphalt technology. The mixtures were prepared with 0%, 20%, 30%, 40%, and 50% content of reclaimed asphalt pavement (RAP) and modified bitumen binder using Sasobit and Zycotherm additives. The dynamic elastic modulus tests were conducted by varying the temperature from 10 °C to 50 °C at different frequencies from 0.1 Hz to 25 Hz. Various common quantitative indications, such as root mean square error (RMSE), mean absolute error (MAE), and correlation coefficient (R) were used to validate and compare the prediction capability of different models. The results showed that machine learning models could accurately predict the dynamic elastic modulus of WMA using up to 50% RAP and fabricated by warm mix asphalt technology. Out of these models, the Boosted algorithm (R = 0.9956) was found as the best predictor compared with those obtained by ANN-LMN (R = 0.9954), SVM (R = 0.9654), and GPR (R= 0.9865). Thus, it could be concluded that Boosted is a promising cost-effective tool for the prediction of the dynamic elastic modulus (E*) of WMA. This study might help in reducing the cost of laboratory experiments for the determination of the dynamic modulus (E*).

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Elkholy, Mahmoud M., and Fathi Abd-Elkader. "Optimal energy saving of doubly fed induction motor based on scalar rotor voltage control and water cycle algorithm." COMPEL - The international journal for computation and mathematics in electrical and electronic engineering 38, no. 2 (2019): 793–814. http://dx.doi.org/10.1108/compel-05-2018-0225.

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Purpose This paper aims to present an optimal variable speed drive of a doubly fed induction motor (DFIM) with minimum losses and reduced inverter capacity. The operation with minimum losses ensures that the DFIM develops the required load torque at desired speed with maximum energy saving. Moreover, the control of rotor voltage ensures the reduced inverter capacity. The water cycle algorithm (WCA) as one of meta-heuristic optimization techniques is used to estimate the optimal rotor voltages to drive the DFIM with minimum losses. The results of WCA are confirmed with other well-known and reliable optimization method such as particle swarm optimization along with classical method. Design/methodology/approach The DFIM is an efficient alternative solution of synchronous motor (SM) because of its speed is synchronized with both stator and rotor frequencies regardless the load torque. As a result, the speed of variable speed drive associated with DFIM can be controlled through a rotor inverter with reduced capacity rather than SM. The output voltage of rotor inverter is controlled to develop the demanded output power with minimum motor losses. Findings A complete DFIM drive model is developed under MATLAB/SIMULINK environment using d-q dynamic model to verify the strength and significance of the proposed controller. An experimental setup using a 300 W three-phase wound rotor induction motor is established to validate the mathematical models and theoretical results. The motor performances with proposed rotor voltage control (minimum losses) are compared with conventional method of constant voltage to frequency ratio (V/f constant). It is found that the proposed WCA based on controller achieves significant reductions in motor losses, input power and rotor inverter power. Originality/value The paper presents an efficient method to maximize the energy saving of DFIM with a reduced inverter capacity using WCA.

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Tan, Xinyu, Zhengtao Huang, Lihua Jiang, et al. "A simple fabrication of superhydrophobic PVDF/SiO2 coatings and their anti-icing properties." Journal of Materials Research 36, no. 3 (2021): 637–45. http://dx.doi.org/10.1557/s43578-020-00034-z.

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AbstractSuperhydrophobic coatings have been regarded as potential promising solutions to many problems, e.g., ice accumulation in the winter seasons. To be practically useful and economically attractive, it is necessary to fabricate such coatings using facile methods, i.e., with minimal steps and low cost. In this work, a polyvinylidene fluoride (PVDF)/SiO2 coating is successfully prepared with a simple dip coating method. It shows impressive superhydrophobic properties with a large water contact angle (WCA) of 159° and a small sliding angle (SA) of less than 3°. Meanwhile, its superhydrophobic properties are robust in a large temperature range of – 30 to 350 °C and in various environments. Moreover, it shows remarkable anti-icing properties by delaying the freezing time (4 times) and reducing (40%) the adhesion of the ice on the substrate. Therefore, this work has displayed a promising approach for fabricating superhydrophobic coatings towards anti-icing applications.

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Li, M. H., Y. D. Li, H. Q. Tan, et al. "Contrast-free MRA at 3.0 T for the detection of intracranial aneurysms." Neurology 77, no. 7 (2011): 667–76. http://dx.doi.org/10.1212/wnl.0b013e3182299f5a.

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Thompson, William, Andy Martwick, and Joel Weltman. "Thompson, W.A. et al. Decimative Multiplication of Entropy Arrays, with Application to Influenza. Entropy, 2009, 11, 351-359." Entropy 11, no. 3 (2009): 384. http://dx.doi.org/10.3390/e110300384.

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Hedges, Brittany K., Nader Soltani, David C. Hooker, Darren E. Robinson, and Peter H. Sikkema. "Control of glyphosate-resistant waterhemp with preemergence herbicides in glyphosate- and dicamba-resistant soybean." Canadian Journal of Plant Science 99, no. 1 (2019): 34–39. http://dx.doi.org/10.1139/cjps-2018-0046.

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Glyphosate-resistant (GR) waterhemp was first discovered in Ontario, Canada, in 2014. In Ontario, GR waterhemp interference in previous studies reduced soybean yield up to 73%. Tank-mixes of herbicides with multiple modes-of-action are important for delaying the evolution of herbicide resistance. The objective of this study was to evaluate the efficacy of pyroxasulfone (150 g a.i. ha−1), S-metolachlor/metribuzin (1943 g a.i. ha−1), pyroxasulfone/sulfentrazone (300 g a.i. ha−1), and pyroxasulfone/flumioxazin (240 g a.i. ha−1) applied preemergence (PRE) with and without the addition of glyphosate/dicamba (1800 g a.e. ha−1) for the control of GR waterhemp in soybean. At 8 wk after treatment application (WAA), glyphosate/dicamba applied PRE controlled GR waterhemp 45%. Pyroxasulfone, S-metolachlor/metribuzin, pyroxasulfone/sulfentrazone, and pyroxasulfone/flumioxazin applied PRE controlled GR waterhemp 79%, 87%, 91%, and 95%, respectively. At 2, 4, 8, and 12 WAA, the addition of glyphosate/dicamba to the aforementioned PRE herbicides did not improve GR waterhemp control. There was no increase in GR waterhemp control with the addition glyphosate/dicamba; however, multiple herbicide modes-of-action should be utilized to reduce the selection intensity for herbicide-resistant weeds.

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Kwee, I. L., Y. Fujii, H. Matsuzawa, and T. Nakada. "Perceptual processing of stereopsis in humans: High-field (3.0-tesla) functional MRI study." Neurology 53, no. 7 (1999): 1599. http://dx.doi.org/10.1212/wnl.53.7.1599.

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Zhang, Hui, Zhuqin Gu, Chun Yao, et al. "Risk factors for possible REM sleep behavior disorders." Neurology 95, no. 16 (2020): e2214-e2224. http://dx.doi.org/10.1212/wnl.0000000000010610.

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ObjectiveTo explore the risk factors for idiopathic REM sleep behavior disorder (RBD) in a community population in Beijing.MethodsParticipants aged 55 years and above were recruited from the Beijing Longitudinal Study on Aging II cohort. We identified individuals with possible RBD (pRBD) using the validated RBD Questionnaire–Hong Kong in 2010. A series of environmental, lifestyle, and other potential risk factors were assessed via standardized questionnaires in 2009. Multivariable logistic regression analysis was performed to investigate the association between the studied factors and pRBD.ResultsOf 7,225 participants who were free of parkinsonism and dementia, 219 (3.0%) individuals were considered as having pRBD. Participants with pRBD reported more nonmotor and motor symptoms of Parkinson disease (PD) with adjusted odds ratios (ORs) ranging from 1.10 to 4.40. Participants with pRBD were more likely to report a family history of parkinsonism or dementia (OR 3.03, 95% confidence interval [CI] 1.23–7.46). There was a significant association between pRBD and self-reported hyperlipidemia (OR 1.51, 95% CI 1.09–2.10), ever smoking (OR 1.79, 95% CI 1.20–2.65), prior carbon monoxide (CO) poisoning (OR 2.30, 95% CI 1.39–3.83), and nonoccupational exposure to pesticides (OR 2.21, 95% CI 1.40–3.50).ConclusionOur study replicated previously reported associations between pRBD and hyperlipidemia, smoking, pesticide exposure, and several prodromal PD symptoms. We also found previously unreported links with a positive family history of parkinsonism or dementia and CO poisoning. Risk factor profiles for pRBD partially resemble those defined for PD, but also differ in distinct ways.

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Wateba, Ihou Nazoba Majesté, Akouda Akessiwe Patassi, Abago Balaka, and Ousséni Tidjani. "Viral Characteristic of HIV Infected Patients Naïf of Anti-Retroviral Therapy with CD4+ T Lymphocytes Rate Greater than 350 per Microliter of Blood in Lomé Togo." World Journal of AIDS 03, no. 04 (2013): 364–66. http://dx.doi.org/10.4236/wja.2013.34047.

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Lipton, Richard B., Peter J. Goadsby, Jeff Smith, et al. "Efficacy and safety of eptinezumab in patients with chronic migraine." Neurology 94, no. 13 (2020): e1365-e1377. http://dx.doi.org/10.1212/wnl.0000000000009169.

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ObjectiveTo evaluate the efficacy and safety of eptinezumab, a humanized anti–calcitonin gene-related peptide monoclonal antibody, in the preventive treatment of chronic migraine (CM).MethodsThe Prevention of Migraine via Intravenous ALD403 Safety and Efficacy–2 (PROMISE-2) study was a phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Adults with CM were randomly assigned to receive IV eptinezumab 100 mg, eptinezumab 300 mg, or placebo administered on day 0 and week 12. The primary endpoint was change from baseline in mean monthly migraine days (MMDs) over weeks 1 to 12.ResultsAmong treated participants (n = 1,072), baseline mean number of MMDs was ≈16.1 across groups. Treatment with eptinezumab 100 and 300 mg was associated with significant reductions in MMDs across weeks 1 to 12 compared with placebo (placebo −5.6, 100 mg −7.7, p < 0.0001 vs placebo; 300 mg −8.2, p < 0.0001 vs placebo). Treatment-emergent adverse events (TEAEs) were reported by 43.5% (100 mg), 52.0% (300 mg), and 46.7% (placebo) of patients. Nasopharyngitis was the only TEAE reported for >2% of eptinezumab-treated patients at an incidence of >2% over placebo; it occurred in the 300 mg eptinezumab arm (eptinezumab 9.4%, placebo 6.0%).ConclusionIn patients with CM, eptinezumab 100 and 300 mg was associated with a significant reduction in MMDs from the day after IV administration through week 12, was well tolerated, and demonstrated an acceptable safety profile.Classification of evidenceThis study provides Class I evidence that for patients with CM, a single dose of eptinezumab reduces MMDs over 12 weeks of treatment.ClinicalTrials.gov identifierNCT02974153.

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Etherton, Mark R., Ona Wu, Pedro Cougo, et al. "Integrity of normal-appearing white matter and functional outcomes after acute ischemic stroke." Neurology 88, no. 18 (2017): 1701–8. http://dx.doi.org/10.1212/wnl.0000000000003890.

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Objective:To characterize the effect of white matter microstructural integrity on cerebral tissue and long-term functional outcomes after acute ischemic stroke (AIS).Methods:Consecutive AIS patients with brain MRI acquired within 48 hours of symptom onset and 90-day modified Rankin Scale (mRS) score were included. Acute infarct volume on diffusion-weighted imaging (DWIv) and white matter hyperintensity volume (WMHv) on T2 fluid-attenuated inversion recovery MRI were measured. Median fractional anisotropy (FA), mean diffusivity, radial diffusivity, and axial diffusivity values were calculated within normal-appearing white matter (NAWM) in the hemisphere contralateral to the acute lesion. Regression models were used to assess the association between diffusivity metrics and acute cerebral tissue and long-term functional outcomes in AIS. Level of significance was set at p < 0.05 for all analyses.Results:Among 305 AIS patients with DWIv and mRS score, mean age was 64.4 ± 15.9 years, and 183 participants (60%) were male. Median NIH Stroke Scale (NIHSS) score was 3 (interquartile range [IQR] 1–8), and median normalized WMHv was 6.19 cm3 (IQR 3.0–12.6 cm3). Admission stroke severity (β = 0.16, p < 0.0001) and small vessel stroke subtype (β = −1.53, p < 0.0001), but not diffusivity metrics, were independently associated with DWIv. However, median FA in contralesional NAWM was independently associated with mRS score (β = −9.74, p = 0.02), along with age, female sex, NIHSS score, and DWIv.Conclusions:FA decrease in NAWM contralateral to the acute infarct is associated with worse mRS category at 90 days after stroke. These data suggest that white matter integrity may contribute to functional recovery after stroke.

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Yiming, Wang, and Gong Ke. "Comparative Study on the Style of Commercial Streets in Traditional Ancient Villages in Gui-Xiang-Gan-Wan Area." IOP Conference Series: Earth and Environmental Science 330 (November 9, 2019): 022087. http://dx.doi.org/10.1088/1755-1315/330/2/022087.

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Taqi, M. Asif, Eytan Raz, Anastasia Vechera, et al. "Early Experience with Comaneci, a Newly FDA-Approved Controllable Assist Device for Wide-Necked Intracranial Aneurysm Coiling." Cerebrovascular Diseases 50, no. 4 (2021): 464–71. http://dx.doi.org/10.1159/000514371.

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Background: Comaneci (Rapid Medical) is a compliant, adjustable mesh that provides temporary scaffolding during coiling of wide-necked intracranial aneurysms (WNAs) that preserves antegrade flow. We report our early multi-institutional experience with the Comaneci device in the USA. Method: We reviewed all patients with WNAs that were treated using the Comaneci device for coil remodeling of ruptured and unruptured aneurysms at 4 institutions between July 2019 and May 2020. Clinical characteristics, angiographic variables, and endovascular results were assessed. Results: A total of 26 patients were included (18 women). The mean age was 62.7 years (range 44–81). Fifteen patients presented with ruptured aneurysms and 11 with unruptured aneurysms. The mean aneurysm neck width was 3.91 mm (range 1.9–6.5) with a mean dome-to-neck ratio of 1.57 (range 0.59–3.39). The mean maximum width was 5.80 mm (range 3.0–9.9) and the mean maximum height was 5.61 mm (range 2.0–11.8). Successful aneurysm occlusion was achieved in 25 of 26 patients. Complete occlusion was achieved in 16 patients, near-complete occlusion was observed in 9 patients, and 1 patient demonstrated residual filling. The mean time of device exposure was 24 min (range 8–76). No vasospasm was observed at the device location. Clot formation on the device was noted in 2 separate cases, but there were no clinical sequelae. There was 1 intraprocedural complication in a case that involved the simultaneous use of 2 Comaneci devices. Conclusions: Our initial experience shows that the Comaneci device is a promising and reliable tool that can safely support coil remodeling of WNAs.

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Journal articles on the topic 'WNA 350'

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