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Relevant bibliographies by topics / Wnt signaling pathway

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Academic literature on the topic 'Wnt signaling pathway'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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Journal articles on the topic "Wnt signaling pathway"

1

Ng, Li, Prameet Kaur, Nawat Bunnag, et al. "WNT Signaling in Disease." Cells 8, no. 8 (2019): 826. http://dx.doi.org/10.3390/cells8080826.

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Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans. Here, we discuss the WNT pathway and its role in human disease and some of the advances in WNT-related treatments.

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Gajos-Michniewicz, Anna, and Malgorzata Czyz. "WNT Signaling in Melanoma." International Journal of Molecular Sciences 21, no. 14 (2020): 4852. http://dx.doi.org/10.3390/ijms21144852.

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WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer. WNT-signaling is classified into two categories: β-catenin-dependent signaling (canonical pathway) and β-catenin-independent signaling (non-canonical pathway), the latter can be further divided into WNT/planar cell polarity (PCP) and calcium pathways. WNT ligands are considered as unique directional growth factors that contribute to both cell proliferation and polarity. Origin of cancer can be div

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Zhu, Yingying, Yajing He, and Runliang Gan. "Wnt Signaling in Hepatocellular Carcinoma: Biological Mechanisms and Therapeutic Opportunities." Cells 13, no. 23 (2024): 1990. https://doi.org/10.3390/cells13231990.

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Hepatocellular carcinoma (HCC), characterized by significant morbidity and mortality rates, poses a substantial threat to human health. The expression of ligands and receptors within the classical and non-classical Wnt signaling pathways plays an important role in HCC. The Wnt signaling pathway is essential for regulating multiple biological processes in HCC, including proliferation, invasion, migration, tumor microenvironment modulation, epithelial–mesenchymal transition (EMT), stem cell characteristics, and autophagy. Molecular agents that specifically target the Wnt signaling pathway have d

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Wallingford, J. B., K. M. Vogeli, and R. M. Harland. "Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway." International Journal of Developmental Biology 45, no. 1 (2001): 225–27. https://doi.org/10.1387/ijdb.11291850.

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The Wnt signaling pathway is increasingly recognized as a highly branched signaling network. Experimental uncoupling of the different branches of this pathway has proven difficult, as many single components are shared downstream by multiple, distinct pathways. In this report, we demonstrate that the upstream Wnt antagonists Xwnt5a and Nxfz-8, which inhibit normal morphogenetic movements during Xenopus gastrulation, act independently of the canonical Wnt signaling pathway. This finding is important, as it highlights the promiscuity of upstream Wnt signaling components and further establishes an

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Li, Jing, Ling Ji, Jieping Chen, Wengeng Zhang та Zhijia Ye. "Wnt/β-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy". BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/964842.

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Cooperating with other signaling pathways, Wnt signaling controls cell proliferation, morphology, motility, and embryonic development destination and maintains the homeostasis of tissues including skin, blood, intestine, and brain by regulating somatic stem cells and their niches throughout adult life. Abnormal regulation of Wnt pathways leads to neoplastic proliferation in these tissues. Recent research shows that Wnt signaling is also associated with the regulation of cancer stem cells (CSCs) through a similar mechanism to that observed in normal adult stem cells. Thus, the Wnt/β-catenin sig

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Li, Xiang, Maria A. Ortiz, and Leszek Kotula. "The physiological role of Wnt pathway in normal development and cancer." Experimental Biology and Medicine 245, no. 5 (2020): 411–26. http://dx.doi.org/10.1177/1535370220901683.

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Over the decades, many studies have illustrated the critical roles of Wnt signaling pathways in both developmental processes as well as tumorigenesis. Due to the complexity of Wnt signaling regulation, there are still questions to be addressed about ways cells are able to manipulate different types of Wnt pathways in order to fulfill the requirements for normal or cancer development. In this review, we will describe different types of Wnt signaling pathways and their roles in both normal developmental processes and their role in cancer development and progression. Additionally, we will briefly

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Zheng, Genggeng, Shuoqi Lin, Shijie Wang, Yuxiang Yan та Dali Zheng. "Regulation of Natural Products on Wnt/β-Catenin Signaling Pathway in Diseases". American Journal of Chinese Medicine 53, № 03 (2025): 709–35. https://doi.org/10.1142/s0192415x25500272.

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The Wnt/β-catenin signaling pathway plays a crucial role in both physiological and pathological conditions. Targeting molecules associated with the Wnt/β-catenin signaling pathway presents a promising approach for disease treatment. The use of natural products in treating various diseases is widespread due to their favorable biocompatibility, low toxicity, and high biological activity. Research has shown that natural products such as curcumin and resveratrol can regulate multiple signaling pathways under disease conditions, including the Wnt/β-catenin signaling pathway. However, the regulatory

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Sharma, Garima, Ashish Ranjan Sharma, Eun-Min Seo, and Ju-Suk Nam. "Genetic Polymorphism in Extracellular Regulators of Wnt Signaling Pathway." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/847529.

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The Wnt signaling pathway is mediated by a family of secreted glycoproteins through canonical and noncanonical mechanism. The signaling pathways are regulated by various modulators, which are classified into two classes on the basis of their interaction with either Wnt or its receptors. Secreted frizzled-related proteins (sFRPs) are the member of class that binds to Wnt protein and antagonizes Wnt signaling pathway. The other class consists of Dickkopf (DKK) proteins family that binds to Wnt receptor complex. The present review discusses the disease related association of various polymorphisms

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Afroz, Rizwana, and Julie E. Goodwin. "Wnt Signaling in Atherosclerosis: Mechanisms to Therapeutic Implications." Biomedicines 12, no. 2 (2024): 276. http://dx.doi.org/10.3390/biomedicines12020276.

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Atherosclerosis is a vascular disease in which inflammation plays a pivotal role. Receptor-mediated signaling pathways regulate vascular inflammation and the pathophysiology of atherosclerosis. Emerging evidence has revealed the role of the Wnt pathway in atherosclerosis progression. The Wnt pathway influences almost all stages of atherosclerosis progression, including endothelial dysfunction, monocyte infiltration, smooth muscle cell proliferation and migration, and plaque formation. Targeting the Wnt pathway to treat atherosclerosis represents a promising therapeutic approach that remains un

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Gao, Yongguang, Na Chen, Zhanda Fu, and Qing Zhang. "Progress of Wnt Signaling Pathway in Osteoporosis." Biomolecules 13, no. 3 (2023): 483. http://dx.doi.org/10.3390/biom13030483.

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Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density diminishing, and degeneration of bone microstructure, which is accompanied by a tendency toward bone fragility and a predisposition to fracture. More than 200 million people worldwide suffer from osteoporosis, and the cost of treating osteoporotic fractures is expected to reach at least $25 billion by 2025. The generation and development of osteoporosis are regulated by genetic factors and regulatory factors such as TGF-β, BMP, and FGF through multiple pathways, including the Wnt signaling pathway, the Notc

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Dissertations / Theses on the topic "Wnt signaling pathway"

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Mailavaram, Sravanthi. "Database for the Study of Biological Pathways, with Wnt Signaling Pathway Use Case." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1227118211.

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Asuni, Ayodeji. "The role of the WNT signaling (i.e. signalling) pathway in Alzheimer's disease." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409682.

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Sheldahl, Laird Charles. "Molecular components of the Wnt/calcium pathway /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/6294.

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Xing, Yi. "Structural and biochemical studies on the Wnt/[beta]-catenin signaling pathway and the PI3K/CISK signaling pathway /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/5680.

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Curto, Navarro Josué. "Initial events in non-canonical Wnt signaling." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/461992.

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La ruta canònica i no canònica de Wnt activen vies de senyalització que generen respostes cel·lulars diferents. Tanmateix, els esdeveniments de senyalització inicials com a resposta a l'estimulació amb els lligands mostren alguns elements comuns. Les dues vies requereixen que el receptor Frizzled (Fz) promogui la fosforilació i el reclutament de Dishevelled al complex de senyalització. En la ruta canònica de Wnt, la CK1ε associada a la p120-catenina s'ha d'activar per permetre la fosforilació i el reclutament de Dvl a Fz. Aquí demostrem que aquestes dues proteïnes també són necessàries per pro

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Tokarew, Nicholas. "The Role of Norrie Disease Pseudoglioma (Ndp) in Cerebellar Development/Tumorigenesis and Its Relationship with the Sonic Hedgehog Pathway." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36936.

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Medulloblastoma (MB), a cancer of the cerebellum, is the most common solid tumor affecting children. In the cerebellum, Sonic Hedgehog (Shh) drives the proliferative expansion of granule neuron progenitors (GNP). These cells are located in the external granule layer (EGL) and are the cells of origin of Shh-MB. We recently identified Norrie Disease Pseudoglioma (Ndp) as a novel downstream target of Hh signaling in the developing retina. Ndp encodes an X-linked cysteine-rich secreted protein called Norrin, which is best known for its role in angiogenesis and blood brain barrier (BBB) maintenance

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Fang, Ming. "Wnt/ß-catenin signaling pathway in non-myocyte lineages in the heart." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1458299605.

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Liu, Jing. "Biochemical and structural studies of key components in the Wnt signaling pathway /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/5685.

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Arngården, Linda. "Analysis of signaling pathway activity in single cells using the in situ Proximity Ligation Assay." Doctoral thesis, Uppsala universitet, Molekylära verktyg, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281716.

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A cell that senses signals from its environment uses proteins for signal transduction via post translational modifications (PTMs) and protein- protein interactions (PPIs) from cell membrane into the nucleus where genes controlling cell proliferation, differentiation and apoptosis can be turned on or off, i.e. changing the phenotype or fate of the cell. Aberrations within such proteins are prone to cause diseases, such as cancer. Therefore, it is important so study aberrant signaling to be able to understand and treat diseases. In this thesis, signaling aberrations of PTMs and PPIs were analyze

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Selvadurai, Hayden John. "Dynamics of Wnt/β-catenin signalling during cerebellum development". Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6484.

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Medulloblastomas are tumours of cerebellar origin and are thought to arise from the malignant transformation of progenitor cells in the developing cerebellum. A number of developmental signalling pathways are required for the precise cell specification, proliferation, migration and differentiation involved in forming the mature cerebellum and it is the dysregulation of these processes that can lead to the eventual formation of a tumour. Genes encoding components of the canonical Wnt/β-catenin signaling pathway are mutated in around 15% of medulloblastomas and germline mutations that activate t

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Books on the topic "Wnt signaling pathway"

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Vincan, Elizabeth. Wnt Signaling: Volume 2, Pathway Models. Humana Press, 2010.

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Wnt Signaling Vol. 2: Volume 2, Pathway Models. Humana Press, 2008.

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Vincan, Elizabeth. Wnt Signaling : Volume 1: Pathway Methods and Mammalian Models. Humana Press, 2011.

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Wnt Signaling Vol. 2 : Volume 1: Pathway Methods and Mammalian Models. Humana Press, 2008.

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Kockeritz, Lisa Karen. Roles of Wnt signalling pathway components in embryonic development and disease. 2005.

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Zaffran, Stéphane. Cardiac growth II: Cardiomyocyte polarization. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0010.

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During vertebrate embryogenesis, the planar cell polarity (PCP) signalling pathway is responsible for cell movements essential for convergent extension during gastrulation, neural tube closure, neural crest cell migration, and heart morphogenesis. In the heart, the non-canonical Wnt/PCP pathway regulates cell polarity, cell shape, and cell dynamics during formation of the cardiac crescent and deployment of second heart field cardiac progenitors to the poles of the heart tube. PCP signalling is also essential for the establishment of left–right patterning in the early embryo. This chapter revie

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Mora-Blanco, Eva Lorena. Regulation of the Wnt and Hedgehog Signaling Pathways by the Swi/Snf Complex. 2011.

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Burdick, Katherine E., Luz H. Ospina, Stephen J. Haggarty, and Roy H. Perlis. The Neurobiology and Treatment of Bipolar Disorder. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0020.

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Bipolar disorder (BPD) is a severe mood disorder that often has psychotic features. Its most severe forms are more common and significantly more likely to cause disability than originally thought. Studies of high-risk children have found them to be at increased risk for a variety of symptoms and neurobiological abnormalities. In contrast to schizophrenia, there is no formal prodromal syndrome that has been identified, and cognitive abnormalities do not precede the onset of the disorder. Abnormal sleep and circadian rhythms are prominent and have led to intriguing biological models. Neurobiolog

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Book chapters on the topic "Wnt signaling pathway"

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Monga, Satdarshan P. Singh. "The WNT/β-catenin pathway." In Signaling Pathways in Liver Diseases. John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118663387.ch18.

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Monga, Satdarshan P. S. "The WNT/β-Catenin Pathway." In Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00150-5_25.

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Polakis, Paul. "An Introduction to Wnt Signaling." In Targeting the Wnt Pathway in Cancer. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-8023-6_1.

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Manegold, Philipp C., Jia-Ling Teo, and Michael Kahn. "Wnt Signaling in Stem Cells." In Targeting the Wnt Pathway in Cancer. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-8023-6_3.

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Barish, Grant D., and Bart O. Williams. "The Wnt Signal Transduction Pathway." In Signaling Networks and Cell Cycle Control. Humana Press, 2000. https://doi.org/10.1007/978-1-59259-218-0_4.

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Thompson, Michael, Kari Nejak-Bowen, and Satdarshan P. S. Monga. "Crosstalk of the Wnt Signaling Pathway." In Targeting the Wnt Pathway in Cancer. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-8023-6_4.

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Müschen, Markus. "WNT/β-Catenin Signaling in Leukemia." In Targeting the Wnt Pathway in Cancer. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-8023-6_6.

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Schambony, Alexandra, Guido J. R. Zaman, and Folkert Verkaar. "Molecular Mechanisms of Wnt Pathway Specificity." In Wnt Signaling in Development and Disease. John Wiley & Sons, Inc, 2014. http://dx.doi.org/10.1002/9781118444122.ch7.

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Shitashige, Miki, and Tesshi Yamada. "Targeting of Wnt Signaling Inside the Nucleus." In Targeting the Wnt Pathway in Cancer. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-8023-6_10.

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Lee, Ho-Jin, Xinxin Zhang, and Jie J. Zheng. "Inhibiting the Wnt Signaling Pathway with Small Molecules." In Targeting the Wnt Pathway in Cancer. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-8023-6_9.

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Conference papers on the topic "Wnt signaling pathway"

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Azam, M. R., A. I. Bhatti, A. Arshad, and M. Z. Babar. "Sensitivity analysis of Wnt Signaling Pathway." In 2013 10th International Bhurban Conference on Applied Sciences and Technology (IBCAST 2013). IEEE, 2013. http://dx.doi.org/10.1109/ibcast.2013.6512143.

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Xu, Xian, and Yanbin Yu. "Modeling and Verifying WNT Signaling Pathway." In Third International Conference on Natural Computation (ICNC 2007). IEEE, 2007. http://dx.doi.org/10.1109/icnc.2007.476.

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Nayakanti, S. R., A. Tretyn, S. Dabral, et al. "Wnt-Signaling Pathway Drives Right Ventricular Remodeling." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6072.

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Tretyn, Aleksandra, Soni Pullamsetti, Klaus-Dieter Schlueter, et al. "Wnt-Signaling Pathway In Experimental Right Heart Hypertrophy." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4982.

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Alazi, Feras, Turkan Haliloglu, and Kutlu O. Ulgen. "Reconstruction of Wnt/Calcium signaling pathway in C. elegans." In 2009 14th National Biomedical Engineering Meeting. IEEE, 2009. http://dx.doi.org/10.1109/biyomut.2009.5130319.

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Jia, Peilin, and Zhongming Zhao. "Convergent evidence for Wnt signaling pathway in psychotic disorders." In 2010 Biomedical Sciences and Engineering Conference (BSEC). IEEE, 2010. http://dx.doi.org/10.1109/bsec.2010.5510823.

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McLaughlin, Margaret. "Abstract IA14: Targeting the Wnt signaling pathway in cancer." In Abstracts: AACR Special Conference on Developmental Biology and Cancer; November 30 - December 3, 2015; Boston, Massachusetts. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1557-3125.devbiolca15-ia14.

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Liu, Wenzhu. "The intersection between Wnt signaling pathway and cancer metabolism." In 7TH INTERNATIONAL CONFERENCE ON MATHEMATICS: PURE, APPLIED AND COMPUTATION: Mathematics of Quantum Computing. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0111663.

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Kulebyakina, M. A., D. A. Butuzova, N. D. Basalova, and A. Yu Efimenko. "DKK3 SECRETED BY MESENCHYMAL STROMAL CELLS PREVENTS FIBROBLAST-TO-MYOFIBROBLAST TRANSITION." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-287.

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It is well known that mesenchymal stromal cells (MSCs) prevent the development of fibrosis in a paracrine manner; still, the underlying mechanisms have not yet been studied. Using proteomic analysis, we identified the DKK3 protein, a regulator of the Wnt signaling pathway, in the MSC secretome. We also demonstrated that the DKK3 protein in the MSC secretome suppresses the canonical Wnt signaling pathway in fibroblasts and prevents myofibroblast differentiation.

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chehover, michal, Claes Tropé, Reuven Reich, and Ben Davidson. "Abstract 5166: THE WNT SIGNALING PATHWAY IN THE OVARIAN CARCINOMA." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5166.

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Reports on the topic "Wnt signaling pathway"

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Virdi, Amarjit S. Modulating Wnt Signaling Pathway to Enhance Allograft Integration in Orthopaedic Trauma Treatment. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada581575.

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Virdi, Amarjit S. Modulating Wnt Signaling Pathway to Enhance Allograft Integration in Orthopedic Trauma Treatment. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada594157.

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Lin, Xinhua. The Role(s) of Heparan Sulfate Proteoglycan(s) in the wnt-1 Signaling Pathway. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada382401.

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Masckauchan, T. N. Activation of Alternative Wnt Signaling Pathways in Human Mammary Gland and Breast Cancer Cells. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada429686.

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Masckauchan, T. N. Activation of Alternative Wnt Signaling Pathways in Human Mammary Gland and Breast Cancer Cells. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada459280.

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Friedman, Haya, Julia Vrebalov, and James Giovannoni. Elucidating the ripening signaling pathway in banana for improved fruit quality, shelf-life and food security. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7594401.bard.

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Background : Banana being a monocot and having distinct peel and pulp tissues is unique among the fleshy fruits and hence can provide a more comprehensive understanding of fruit ripening. Our previous research which translated ripening discoveries from tomato, led to the identification of six banana fruit-associated MADS-box genes, and we confirmed the positive role of MaMADS1/2 in banana ripening. The overall goal was to further elucidate the banana ripening signaling pathway as mediated by MADS-boxtranscriptional regulators. Specific objectives were: 1) characterize transcriptional profiles

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Horwitz, Benjamin, and Barbara Gillian Turgeon. Secondary Metabolites, Stress, and Signaling: Roles and Regulation of Peptides Produced by Non-ribosomal Peptide Synthetases. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7696522.bard.

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Fungal pathogens of plants produce a diverse array of small molecules. Often referred to as secondary metabolites because they were thought to be dispensable for basic functions, they may indeed have central roles as signals for the fungal cell, and in interactions with the host. We have identified more than a dozen genes encoding nonribosomal peptide synthetases (NPS) in Cochliobolusheterostrophus, the agent of southern corn leaf blight. The aim of this project was to identify roles of these genes in stress responses and signaling. The first objective was to test a complete collection of C. h

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Levy, Maggie, Raymond Zielinski, and Anireddy S. Reddy. IQD1 Function in Defense Responses. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7699842.bard.

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The main objective of the proposed research was to study IQD1's mechanism of action and elucidate its role in plant protection. Preliminary experiments suggest that IQD1 binds CaM in a Ca²⁺-dependent manner and functions in general defense responses. We propose to identify proteins and genes that interact with IQD1, which may provide some clues to its mechanism of action. We also plan to dissect IQD1's integration in defense pathways and to study and modulate its binding affinity to CaM in order to enhance crop resistance. Our specific objectives were: (1) Analysis of IQD1's CaM-binding proper

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Kapulnik, Yoram, Maria J. Harrison, Hinanit Koltai, and Joseph Hershenhorn. Targeting of Strigolacatones Associated Pathways for Conferring Orobanche Resistant Traits in Tomato and Medicago. United States Department of Agriculture, 2011. http://dx.doi.org/10.32747/2011.7593399.bard.

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This proposal is focused on examination of two plant interactions: parasitic with Orobanche, and symbiosis with arbuscular mycorrhiza fungi (AMF), and the involvement of a newly define plant hormones, strigolactones (SLs), in these plant interactions. In addition to strigolactones role in regulation of above-ground plant architecture, they are also known to be secreted from roots, and to be a signal for seed germination of the parasitic plants Orobanche. Moreover, secreted strigolactones were recognized as inducers of AMFhyphae branching. The present work was aimed at Generation of RNAi mutant

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