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Dissertations / Theses on the topic 'Wnt signaling pathway'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Mailavaram, Sravanthi. "Database for the Study of Biological Pathways, with Wnt Signaling Pathway Use Case." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1227118211.

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2

Asuni, Ayodeji. "The role of the WNT signaling (i.e. signalling) pathway in Alzheimer's disease." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409682.

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3

Sheldahl, Laird Charles. "Molecular components of the Wnt/calcium pathway /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/6294.

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4

Xing, Yi. "Structural and biochemical studies on the Wnt/[beta]-catenin signaling pathway and the PI3K/CISK signaling pathway /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/5680.

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5

Curto, Navarro Josué. "Initial events in non-canonical Wnt signaling." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/461992.

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La ruta canònica i no canònica de Wnt activen vies de senyalització que generen respostes cel·lulars diferents. Tanmateix, els esdeveniments de senyalització inicials com a resposta a l'estimulació amb els lligands mostren alguns elements comuns. Les dues vies requereixen que el receptor Frizzled (Fz) promogui la fosforilació i el reclutament de Dishevelled al complex de senyalització. En la ruta canònica de Wnt, la CK1ε associada a la p120-catenina s'ha d'activar per permetre la fosforilació i el reclutament de Dvl a Fz. Aquí demostrem que aquestes dues proteïnes també són necessàries per pro

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6

Tokarew, Nicholas. "The Role of Norrie Disease Pseudoglioma (Ndp) in Cerebellar Development/Tumorigenesis and Its Relationship with the Sonic Hedgehog Pathway." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36936.

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Medulloblastoma (MB), a cancer of the cerebellum, is the most common solid tumor affecting children. In the cerebellum, Sonic Hedgehog (Shh) drives the proliferative expansion of granule neuron progenitors (GNP). These cells are located in the external granule layer (EGL) and are the cells of origin of Shh-MB. We recently identified Norrie Disease Pseudoglioma (Ndp) as a novel downstream target of Hh signaling in the developing retina. Ndp encodes an X-linked cysteine-rich secreted protein called Norrin, which is best known for its role in angiogenesis and blood brain barrier (BBB) maintenance

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7

Fang, Ming. "Wnt/ß-catenin signaling pathway in non-myocyte lineages in the heart." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1458299605.

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8

Liu, Jing. "Biochemical and structural studies of key components in the Wnt signaling pathway /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/5685.

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9

Arngården, Linda. "Analysis of signaling pathway activity in single cells using the in situ Proximity Ligation Assay." Doctoral thesis, Uppsala universitet, Molekylära verktyg, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281716.

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A cell that senses signals from its environment uses proteins for signal transduction via post translational modifications (PTMs) and protein- protein interactions (PPIs) from cell membrane into the nucleus where genes controlling cell proliferation, differentiation and apoptosis can be turned on or off, i.e. changing the phenotype or fate of the cell. Aberrations within such proteins are prone to cause diseases, such as cancer. Therefore, it is important so study aberrant signaling to be able to understand and treat diseases. In this thesis, signaling aberrations of PTMs and PPIs were analyze

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10

Selvadurai, Hayden John. "Dynamics of Wnt/β-catenin signalling during cerebellum development". Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6484.

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Medulloblastomas are tumours of cerebellar origin and are thought to arise from the malignant transformation of progenitor cells in the developing cerebellum. A number of developmental signalling pathways are required for the precise cell specification, proliferation, migration and differentiation involved in forming the mature cerebellum and it is the dysregulation of these processes that can lead to the eventual formation of a tumour. Genes encoding components of the canonical Wnt/β-catenin signaling pathway are mutated in around 15% of medulloblastomas and germline mutations that activate t

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11

Azzolin, Luca. "Role of TAZ in cancer stem cells and Wnt signaling." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422986.

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The transcriptional co-activator TAZ, known Hippo transducer together with his paralogue YAP, has recently emerged as important player in processes like organ growth and tumorigenesis. Here we focused on two aspects of TAZ biology: the first regards the role of TAZ as molecular determinant of breast cancer stem cells (CSCs); the second is the characterization of TAZ as downstream mediator of Wnt signaling. Using a bioinformatic approach, we discovered that more-malignant/CSC-enriched primary breast cancers, compared to well-differentiated/non-methastatic tumors, display an elevated activity

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12

Kramer, Monika [Verfasser]. "The WNT/β-catenin [WNT-beta-catenin] pathway : profibrotic signaling in fibroblasts in idiopathic pulmonary fibrosis / vorgelegt von Monika Kramer". Giessen : VVB Laufersweiler, 2010. http://d-nb.info/1009523570/34.

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13

Neal, James Thomas. "Bacterial Stimulation of Intestinal Proliferation via the Wnt Pathway in Zebrafish." Thesis, University of Oregon, 2011. http://hdl.handle.net/1794/12119.

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xi, 62 p. : ill. (some col.)<br>This dissertation describes research into microbial influences on host signaling in the zebrafish intestine. Vertebrate organisms are consistently exposed to microbes, especially on epithelial tissues that are exposed to the environment, such as the skin and the gastrointestinal tract. The close association between these tissues and microbes over time has resulted in a symbiotic state, whereby microorganisms have gained the ability to utilize vertebrate epithelia as a niche for replication and the acquisition of nutrients. These associations run the gamut from b

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14

Mandrekar, Noopur. "Characterization of a novel component of Wnt signaling pathway using zebrafish as a model organism." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/400345.

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Biology<br>Ph.D.<br>Wnt signaling plays important role in many aspects of embryogenesis such as cell proliferation, cell fate specification, cell polarity and organogenesis(Clevers 2006, van Amerongen and Nusse 2009). Wnt ligands have been shown to activate several intra-cellular signaling cascades, including the canonical or Wnt/-catenin dependent pathway and the non-canonical or -catenin independent pathway. Dishevelled (Dvl) occupies a key position at crossroads of all branches of Wnt signaling cascade. To understand, how Dishevelled (Dvl) may channel signaling into the downstream branches,

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15

Adams, Jason Samuel. "Regulation of Sensory Neurogenesis in the Trigeminal Placode: Notch Pathway Genes, Pax3 Isoforms, and Wnt Ligands." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3144.

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This dissertation is divided into three chapters, each discussing the study of different regulatory molecules involved in sensory neurogenesis occurring in the trigeminal placode. Chapter one is a spatiotemporal description of Notch pathway genes in chick opV placode by stage-specific expression analysis, showing expression of many Notch pathway genes and effectors in the opV placode. Notch pathway gene expression is primarily confined to the ectoderm with highest expression of these genes at the beginning stages of peak neuronal differentiation. This information preceded studies of the functi

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16

Ferreira, Catarina Domingues. "WNT/ß-catenin and Hedgehog signaling pathways as therapeutic targets in B cell neoplasms." Master's thesis, Universidade de Aveiro, 2018. http://hdl.handle.net/10773/22676.

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Mestrado em Bioquímica - Métodos Biomoleculares<br>As neoplasias de células B são caracterizadas por um grupo heterogéneo de doenças que incluem linfomas de células B e doenças de células plasmáticas, entre outras. O mieloma múltiplo (MM) é uma neoplasia maligna originada pela proliferação de células plasmáticas monoclonais que permanece incurável. Esta proliferação de células plasmáticas malignas no microambiente da medula óssea produz proteína monoclonal no sangue ou na urina e está associada a sinais malignos. Representa aproximadamente 1% das doenças neoplásicas e 10% a 15% das neoplasias

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17

Zhu, Xin. "Genetic interactions patterning the Tribolium fate map." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/35787.

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Doctor of Philosophy<br>Division of Biology<br>Susan J. Brown<br>A segmented body plan is conserved in vertebrates and arthropods. Comparative studies implicate a conserved mode of A-P axis patterning and segmentation among vertebrates: Wnt signaling is involved in fate map patterning along the A-P axis and in segmentation in the posterior region of the embryo. On the other hand, comparative studies in arthropods have revealed distinct modes of development between long and short germ insects, which differ both morphologically and genetically. In the short germ insect Tribolium, a Wnt activity

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18

Arató, Krisztina. "Regulation of the stability of the protein kinase DYRK1A: establishing connections with the Wnt signaling pathway." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/38524.

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DYRK1A is the most studied member of the DYRK family of protein kinases, because is one of the human chromosoma 21 proteins for which changes in gene dosage result in neuropathological alterations. DYRKs are activated by autophosphorylation on a tyrosine residue in the activation loop, a one-off event that takes place during translation. Accordingly, DYRK1A would be constitutively active once is synthesized. However, DYRK1A is extremely sensitive to gene dosage, and thus it is predictable that not only its activity but also its actual protein amounts have to be tightly regulated by mechanisms

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19

Falcone, Emilia Liana. "Ovarian cancer cells exhibit aberrations in the Wnt signaling pathway, which affect cell proliferation and cadherin expression." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101121.

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Ovarian cancer is the leading cause of death from a gynecological malignancy in North America. It is an incomplete understanding of the early molecular events in ovarian carcinogenesis which limit our ability to diagnose and effectively treat this disease at a stage when it is still curable. The Wnt/beta-catenin canonical signaling pathway is involved in development, wound repair, and tumorigenesis. Studies examining the involvement of Wnt/canonical signaling in ovarian carcinogenesis, however, have only recently begun to emerge. In this study, we hypothesize that ovarian cancer cells exhibit

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20

Keller, Amelie Dorothea [Verfasser], and Giesa [Akademischer Betreuer] Tiegs. "Coffee interferes with HCV replication by inhibition of wnt signaling pathway / Amelie Dorothea Keller. Betreuer: Giesa Tiegs." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/1068931485/34.

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21

Takai, Akira. "Anterior neural development requires Del1, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway." Kyoto University, 2011. http://hdl.handle.net/2433/135377.

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22

Evans, Justin. "A Role for Wnt-β-Catenin Signaling in Positioning Motor Neurons Along the Ventral Nerve Cord in C. Elegans". Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38376.

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During C. elegans embryogenesis, the DD, DA, and DB motor neurons arise from left and right lineages, move towards the midline and intercalate into a single tract to form the ventral nerve cord (VNC). Recently, the non-canonical Wnt-planar cell polarity was shown to regulate cell intercalation during VNC assembly. Disruption of this pathway causes DD neurons to shift anteriorly along the anterior-posterior (AP)-axis. Here, we investigated the role of the canonical Wnt-β-catenin pathway in positioning neurons in the VNC. Mutations in canonical Wnt pathway components, including bar-1/β-catenin a

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23

Wu, Mingfu. "A novel non-canonical WNT pathway regulates the asymmetric b cell division in Caenorhabditis elegans." Diss., Kansas State University, 2005. http://hdl.handle.net/2097/355.

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Doctor of Philosophy<br>Department of Biology<br>Michael A. Herman<br>The polarities of several cells that divide asymmetrically during C. elegans development are controlled by Wnt signaling. LIN-44/Wnt and LIN-17/Fz control the polarities of cells in the tail of developing C. elegans larvae, including the male-specific blast cell, B, which divides asymmetrically to generate a larger anterior daughter and a smaller posterior daughter. We determined that the canonical Wnt pathway components are not involved in the control of B cell polarity. However, POP-1/Tcf is involved and asymmetrically dis

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24

Geron, Lenisa. "Estudo da modulação da via Wnt pelo inibidor de Aurora-quinases AMG900 em linhagens celulares de meduloblastoma pediátrico." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-04012017-095955/.

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O meduloblastoma (MB) é o tumor cerebral maligno mais comum na infância. A formação/progressão desta neoplasia foi associada a alterações moleculares, que inclui a desregulação da via de sinalização Wingless (Wnt), responsável pelo desenvolvimento embrionário. Além disso, as proteínas da família Aurora-quinases (A, B e C) têm sido amplamente estudadas, uma vez que a Aurora A e B foram encontrados hiperexpressas em diversas neoplasias, como o MB. Estudos recentes mostraram que existe uma associação entre a Via Wnt e as Aurora-quinases. No entanto, poucos trabalhos foram realizados para confirma

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Leal, Letícia Ferro. "Via Wnt/?-catenina em tumores adrenocorticais pediátricos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/17/17144/tde-06012016-181445/.

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Introdução: Em crianças das regiões Sul e Sudeste do Brasil há uma incidência elevada de tumores adrenocorticais (TAC). Anormalidades da ?-catenina tem sido encontradas em TAC em adultos e sugerem a ativação da via Wnt/ -catenina nestes tumores. No entanto, não há estudos avaliando o papel desta via em casuísticas de TAC pediátricos. Objetivos: Avaliar o papel da via Wnt/catenina e mutações do gene CTNNB1 na tumorigênese adrenocortical pediátrica. Indivíduos, Material e Métodos: Foram avaliados 62 pacientes pediátricos com TAC oriundos de dois centros de referência. Controles: córtex adrenal d

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Chabanais, Julien. "Contribution de la protéine O-fucosyltransférase 1( POFUT1) à la différenciation myogénique et à la tumorigenèse colorectale." Thesis, Limoges, 2019. http://www.theses.fr/2019LIMO0039.

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La protéine O-fucosyltransférase 1 (POFUT1) réticulaire, dont le gène est localisé dans la région chromosomique 20q11.21 chez l’Homme, catalyse le transfert d’un fucose qui sera O-lié sur la sérine ou la thréonine présente dans la séquence consensus (C2X4S/TC3), portée par un domaine EGF-like d’une glycoprotéine membranaire ou sécrétée. Le knockdown de Pofut1 (Po -) dans la lignée myoblastique murines C2C12 conduit à la formation de myotubes allongés et minces, à faible nombre de noyaux ainsi qu’à une sous-expression du marqueur myogénique tardif Myf6, suggérant des défauts significatifs dans

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27

Viehweger, Florian [Verfasser], and Alexander [Akademischer Betreuer] Marx. "Inhibition/knock down and stimulation of the canonical WNT/ß Catenin signaling pathway in rhabdomyosarcoma / Florian Viehweger ; Betreuer: Alexander Marx." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1193728916/34.

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28

Usongo, Macalister. "Characterization of the WNT/B-catenin signaling pathway in the development of mouse ovarian surface epithelium (MOSE) and follicular ovulatory capability." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116973.

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Wnts are secreted extracellular signaling molecules that act locally to control diverse developmental processes such as cell fate specification, cell proliferation, and cell differentiation. Three WNT signaling pathways have been identified. The best characterized is the canonical or WNT/β-catenin signaling pathway. Recently, the WNT signaling pathway has been implicated in ovarian development and differentiation. However, little is known about the expression or role of β-catenin/Tcf-signaling activity within ovarian compartments. In order to aid in the ongoing pursuit of elucidating the mecha

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29

Contato, Anna. "Cardiomyocytes generation by programming human pluripotent stem cell fate in microfluidics: from Wnt pathway modulators to synthetic modified mRNA." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3425256.

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Cardiovascular disease (CVD) is still one of the major cause of morbidity and mortality in the world, with ischemic heart disease representing the majority of deaths over the past 10 years. The high burden of the disease, both immediate and chronic, associated with the high costs for the healthcare systems, claim for the development of novel therapeutic strategies. The main issue of current pharmacological and interventional therapeutic approaches is their inability to compensate the great and irreversible loss of functional cardiomycytes (CMs). Because of the limited regenerative capacity of

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30

Bayerlová, Michaela [Verfasser], Tim [Akademischer Betreuer] Beißbarth, and Burkhard [Akademischer Betreuer] Morgenstern. "Pathway and network analyses in context of Wnt signaling in breast cancer / Michaela Bayerlová. Betreuer: Tim Beißbarth. Gutachter: Tim Beißbarth ; Burkhard Morgenstern." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/108560196X/34.

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31

Matzelle, Melissa M. "Inflammation Inhibits Osteoblast-Mediated Bone Formation in Rheumatoid Arthritis and Regulates the Wnt and BMP Signaling Pathways: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/596.

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Osteoclast-mediated focal articular bone erosion is a hallmark of rheumatoid arthritis, a disease of inflammation-induced bone loss. Inflammation in the bone microenvironment enhances osteoclast differentiation leading to bone erosion. Simultaneously, inflammation also inhibits osteoblast-mediated bone formation, further contributing to the net loss of bone. Previous studies have shown a paucity of mature osteoblasts at eroded bone surfaces correlating with suppression of bone formation and upregulation of antagonists of the Wnt pathway, a signaling cascade essential for osteoblast lineage com

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Barrott, Jared James. "Wnt5a Signaling Independently of the Planar Cell Polarity Pathway Resulting in Convergent Extension and Neural Tube Closure During Vertebrate Development." Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2612.pdf.

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33

Sobreira, Debora Rodrigues 1981. "Estudos sobre os genes da família Dapper = origem, evolução e análise da expressão durante a ontogênese dos membros de galinha = Studies on the Dapper gene family : origin, evolution and expression analysis during chicken limb development." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317678.

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Orientadores: Lúcia Elvira Alvares, José Xavier Neto<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-23T10:52:38Z (GMT). No. of bitstreams: 1 Sobreira_DeboraRodrigues_D.pdf: 9430834 bytes, checksum: 1c730ee238256c4ea0f303311fa3283b (MD5) Previous issue date: 2013<br>Resumo: Os genes da família Dapper (Dpr) codificam proteínas adaptadoras capazes de ligar-se fisicamente a diferentes moléculas e modular as vias de sinalização Wnt e TGF-?. Diferentes análises funcionais revelaram que os Dpr atuam na especificação do eixo corp

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Pedrosa, Angelica Vasconcelos 1986. "Análise comparativa da expressão dos genes Vangl1 e Vangl2 durante a ontogênese da galinha (Gallus gallus)." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317674.

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Orientador: Lúcia Elvira Alvares<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-24T17:37:00Z (GMT). No. of bitstreams: 1 Pedrosa_AngelicaVasconcelos_M.pdf: 1992620 bytes, checksum: ed7d02568860e3ccf1e489cf2928818e (MD5) Previous issue date: 2013<br>Resumo: A correta padronização do corpo do embrião requer a atividade de diferentes vias de sinalização. Dentre elas, uma que se destaca é via de sinalização Wnt de polaridade celular planar (Wnt/PCP), que é responsável pelo controle da polaridade celular e pela organizaç

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35

Omeiri, Hanin. "Rôles des altérations des gènes CTNNB1 et de ZNRF3 dans les carsinomes de la corticosurrénale." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB005.

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Les carcinomes de la cortico-surrénale (CCS) sont des tumeurs de mauvais pronostic et les thérapies sont encore limitées. La chirurgie reste à ce jour le seul traitement efficace. La compréhension des mécanismes de la tumorigenèse cortico-surrénalienne et l'identification des gènes et des voies de signalisation impliquées sont nécessaires pour identifier de nouvelles cibles thérapeutiques. Ces dernières années, plusieurs études de génomique ont été réalisées sur des cohortes indépendantes de CCS et ont mis en évidence l'existence de deux groupes de CCS ayant des profils d’expression génique pa

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Loregger, Anke Verfasser], de Angelis Martin [Akademischer Betreuer] [Hrabé, and Markus [Akademischer Betreuer] Gerhard. "Characterization of RNF43, a novel negative regulator of the Wnt signaling pathway / Anke Loregger. Gutachter: Martin Hrabé de Angelis ; Markus Gerhard. Betreuer: Martin Hrabé de Angelis." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1034641964/34.

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Spadoni, I. "IDENTIFICATION AND CHARACTERIZATION OF THE 'GUT VASCULAR BARRIER'." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/234155.

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In order to protect the body from a wide range of harmful environmental agents, the intestine has developed a number of barrier mechanisms to limit the entry of potential hazards. These include the physical barrier formed by the epithelial layer and the intestinal immune system that is important to induce either tolerance against food antigens and intestinal flora or inflammatory responses against dangerous microorganisms. It has been demonstrated that tolerance against commensal bacteria is strictly compartmentalized, in the sense that the systemic immune system is completely unprimed by th

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Santos, Carla Cristine Crude dos. "Ação de agonistas da via Wnt/beta-catenina em células T CD4+ murinas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-26082015-110639/.

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A via canônica Wnt/beta-catenina regula várias funções em vertebrados, incluindo diferenciação de células T, bem como a proliferação, sobrevivência, morfogênese e migração de vários tipos celulares. As células T CD4+ é fundamental para a competência imunológica. Foi observado pelo nosso grupo que células T CD4+ humanas apresentam ativação da via Wnt/beta-catenina após tratamento com sais de lítio ou outros agonistas da via. A ativação desta via induziu a proliferação de células T CD4+ naive e de memória central. Em conjunto, estes dados sugerem um importante papel da via Wnt/beta-catenina na h

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Yang, Linlin [Verfasser], Iver [Akademischer Betreuer] Petersen, Sven [Akademischer Betreuer] Perner, and Otmar [Akademischer Betreuer] Huber. "Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/ß-Catenin signaling pathway in human lung cancer / Linlin Yang. Gutachter: Iver Petersen ; Sven Perner ; Otmar Huber." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2013. http://d-nb.info/1035637871/34.

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Saad, Carla Gonçalves Schahin. "Baixos níveis de esclerostina: preditor de processo inflamatório persistente em pacientes com espondilite anquilosante sob terapia anti-TNF&#945." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-09012013-180110/.

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Introdução: Baixas concentrações séricas de esclerostina foram descritas em pacientes com Espondilite Anquilosante (EA). No entanto, não existem dados sobre a importância deste inibidor da via de sinalização Wnt em pacientes com EA durante o tratamento com anti fator de necrose tumoral alfa (TNFa). Objetivos: Avaliar longitudinalmente os níveis séricos de esclerostina e sua associação com inflamação e densidade mineral óssea (DMO) em pacientes com EA em tratamento com anti-TNFa. Métodos: Trinta pacientes com EA em atividade foram avaliados no início, 6 e 12 meses, após terapia anti-TNF

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Ignatius, Myron Steve. "Zebrafish Hdac1 Is Reiteratively And Differentially Required During Neural Crest Cell Development And Hdac1 Is A Positive Regulator Of The Non Canonical Wnt Signaling Pathway." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1211981873.

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Rubin, Beatrice. "Aspetti di genetica molecolare e possibili implicazioni terapeutiche nei tumori corticosurrenalici." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423043.

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Background. The most frequent adrenocortical tumors (ACT) are benign forms defined as adrenocortical adenomas (ACA) with an estimated incidence of about 7.3%. Malignant forms, adrenocortical carcinomas (ACC) are rare endocrine tumors with poor prognosis and incidence of 1-2 cases per million people in the population. Currenlty ACC treatments are ineffective and substantially are based on the use of mitotane (o,p'DDD) with or without traditional chemotherapeutic agents. Because of dissimilar prognosis of ACA or ACC it is important to differentiate these two forms. Many tumors stimulate the gr

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Lefèvre, Lucile. "Rôles de la voie de signalisation Wnt/β-caténine et d’un nouveau gène cible, AFF3, dans les carcinomes de la corticosurrénale". Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T010.

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Les carcinomes de la corticosurrénale (CC) sont des tumeurs malignes rares dont le pronostic est globalement sombre et les thérapeutiques encore limitées, la chirurgie étant le seul traitement efficace. Il est donc important de comprendre les mécanismes impliqués dans le développement et l'agressivité des CC. L’activation constitutive de la voie de signalisation Wnt/b-caténine est fréquente dans les CC (40%) et est associée à un caractère agressif. L’objectif de mon projet de thèse était d’étudier l’implication de la voie Wnt/β-caténine dans la tumorigenèse corticosurrénalienne. La lignée cell

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Weber, Iuliia [Verfasser]. "Modulating the glycolytic or Wnt-beta-catenin signaling pathway to generate EBV-specific human CD8+ cytotoxic T lymphocytes with stem cell memory and central memory properties (EBV-CTLSCM/CM) / Iuliia Weber." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1125913827/34.

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Baumann, Fabrizio. "Cell signalling through the Wnt pathway /." [S.l.] : [s.n.], 2004. http://www.zb.unibe.ch/download/eldiss/04baumann_f.pdf.

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Torres, Monica Alexandra. "WNT signaling pathways in Xenopus laevis /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/6293.

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Poliszczuk, Peter. "The Search for Novel Wnt Pathway Modulators." Thesis, 2010. http://hdl.handle.net/1807/25895.

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Signaling pathways are complex and function to transmit signals from the extracellular environment into the cell. Analysis of results obtained from a high throughput siRNA screen led to the identification of Membrane protein palmitoylated 3 (MPP3) and Leukocyte Tyrosine Kinase (LTK) as novel negative regulators of the Wnt pathway. MPP3 is a MAGUK family protein and domain mapping studies indicated that the Guk domain plays a role in the negative regulation of the pathway. LTK, a receptor tyrosine kinase, has several transcript variants one of which lacks the entire kinase domain (LTK∆KD).

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Fafílek, Bohumil. "Adjusting Wnt signaling, nové regulační mechanismy signální dráhy Wnt." Doctoral thesis, 2012. http://www.nusl.cz/ntk/nusl-330405.

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4 Abstract The Wnt pathway is one of the major signaling cascades contributing to multiple cellular processes during embryogenesis, and adult tissue homeostasis and regeneration. Moreover, aberrant activation of the Wnt signaling pathway is connected with development of neoplasia, notably colorectal cancer. The aim of the thesis was to identify new ways of the Wnt pathway regulation to understand better physiological as well as non-physiological mechanisms of Wnt signaling. The results are summarized in four publications. The first article deals with TROY, a member of tumor necrosis factor rec

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Bayerlová, Michaela. "Pathway and network analyses in context of Wnt signaling in breast cancer." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-86E1-F.

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Shu, Chang Feng, and 張鳳書. "The role of Disabled-2 in plakoglobin-mediated Wnt signaling pathway." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/45793012232706055704.

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碩士<br>長庚大學<br>醫學生物技術研究所<br>93<br>Wnt signaling pathway controls many development processes and mediates self-renewal of hematopoietic progenitors. Recent study revealed that plakoglobin, a member of the Armadillo family with dual-function in cell adhesion and signaling, is an activator of Wnt signaling pathway and is involved in leukemogenesis. We further demonstrate that plakoglobin-mediated T cell factor transcriptional activity is modulated by Disabled-2 (Dab2), a signaling molecule that is up-regulated during hematopoietic differentiation. In this study, the molecular mechanism for Dab2 in

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