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Relevant bibliographies by topics / Wogonin

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Academic literature on the topic 'Wogonin'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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Journal articles on the topic "Wogonin"

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Yamada, Yasunari, Hodaka Saito, Masaya Araki, et al. "Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells." Nutrients 14, no. 19 (2022): 3920. http://dx.doi.org/10.3390/nu14193920.

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Fibroblast growth factor 21 (FGF21), which is mainly synthesized and secreted by the liver, plays a crucial role in systemic glucose and lipid metabolism, ameliorating metabolic diseases. In this study, we screened the WAKANYAKU library derived from medicinal herbs to identify compounds that can activate Fgf21 expression in mouse hepatocyte AML12 cells. We identified Scutellaria baicalensis root extract and one of its components, wogonin, as an activator of Fgf21 expression. Wogonin also enhanced the expression of activating transcription factor 4 (ATF4) by a mechanism other than ER stress. Kn

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Wu, Jin-Yi, Lih-Geeng Chen, Chia-Wen Hu, et al. "Immunotoxicity and Anti-Inflammatory Characterizations of Prenylated Flavonoids—The Lipophilic 7-O-Terpenylated Wogonin." Life 12, no. 12 (2022): 2116. http://dx.doi.org/10.3390/life12122116.

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Wogonin, one of the exceptional bioactive flavonoids found abundant in the roots of Huang-Qin (Scutellaria baicalensis Georgi), is a popular health-preserving Chinese medicine. The therapeutic applications can be expanded by improving its bioavailability. The 7-O-terpenylated wogonin consisting one to three prenyl units are chemically synthesized for increasing lipophilic nature for efficient uptake, and also an attempt in mimicry of naturally scarce terpenylated flavonoids found in limited plant families and bee propolis. Wogonin (W) and its lipophilic nature prenyl wogonin (W5), geranyl wogo

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Lin, Chiu-Mei, Yen-Hsu Chen, Jiann-Ruey Ong, Hon-Ping Ma, Kou-Gi Shyu, and Kuan-Jen Bai. "Functional Role of Wogonin in Anti-Angiogenesis." American Journal of Chinese Medicine 40, no. 02 (2012): 415–27. http://dx.doi.org/10.1142/s0192415x12500322.

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Constitutive activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway occurs commonly in cancer cells and endothelial cells, and contributes to angiogenesis. Wogonin is a compound with many biologically relevant properties. We previously reported that wogonin blocked IL-6-induced angiogenesis through suppression of VEGF expression, an important regulator of angiogenesis. However, the pathway involved in the suppressive effect of wogonin on IL-6-induced VEGF has not been completely clarified. This study aimed to investigate the molecular mechanisms pa

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Adibzadeh Sereshgi, Mohammad Mehdi, Ainaz Mashayekhi, and Hasan Norbazargan. "Wogonin Stimulation of Cell Death and Reducing Survivin in MDM-MB231 Breast Tumors." ImmunoRegulation 4, no. 1 (2021): 33–42. http://dx.doi.org/10.32598/immunoregulation.4.1.2.

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Background: Wogonin as a flavonoid compound is known for its anticancer effect through growth control, differentiation, and apoptosis. This study investigates the possible activity of wogonin in inducing cell death of breast tumors MDA-MB231. Materials and Methods: The level of cell proliferation was evaluated by MTT assay. Cycle analysis and the apoptotic rate were assessed by flow cytometry. mRNA level of Bax, Bcl-2, p53, and survivin was evaluated by real-time PCR. Western blot was utilized to assert the relative protein expression. Results: Wogonin inhibits the proliferation of MDA-MB231 o

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Ruibin, Jiang, Jin Bo, Wan Danying, Zhu Chihong, Feng Jianguo, and Gu Linhui. "Therapy Effects of Wogonin on Ovarian Cancer Cells." BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/9381513.

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Background. Wogonin is a plant monoflavonoid and has been reported to induce apoptosis of cancer cells and show inhibitory effect on cancer cell growth. However, the detailed and underlying molecular mechanisms are not elucidated. In this study, we investigated the molecular and biological effects of wogonin in human ovarian A2780 cancer cells. Materials and Methods. We determined the effects of wogonin on the changes of cell cycling and apoptotic responses of cells. Western blot analysis was used to measure the effects of wogonin on protein expressions. Results. Our results showed that treatm

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Sharifi-Rad, Javad, Jesús Herrera-Bravo, Luis A. Salazar, et al. "The Therapeutic Potential of Wogonin Observed in Preclinical Studies." Evidence-Based Complementary and Alternative Medicine 2021 (June 15, 2021): 1–9. http://dx.doi.org/10.1155/2021/9935451.

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Wogonin is a flavonoid found in different plants such as roots of Scutellaria baicalensis Georgi distributed mainly in Asia and Europe. Dried root extracts of S. baicalensis with high content of wogonin, popularly known as “Huang-Qin” or Chinese or baical skullcap, have been used for long time in traditional Chinese medicine. Several health benefits are attributed to wogonin and derivatives showing anti-inflammatory, antiviral, anticancer, and antioxidant effects and more recently antineurodegenerative properties. Preclinical pharmacological activities of wogonin against diverse types of cance

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Fan, Li, Dongbo Qiu, Guo Huang, et al. "Wogonin Suppresses IL-10 Production in B Cells via STAT3 and ERK Signaling Pathway." Journal of Immunology Research 2020 (June 1, 2020): 1–12. http://dx.doi.org/10.1155/2020/3032425.

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Wogonin (5,7-dihydroxy-8-methoxyflavone) is an ingredient of the extracts from Scutellaria baicalensis, which has documented a wide spectrum of anti-inflammatory and antitumor activities, including inhibiting regulatory T cells, regulating effector T cell functions, and mediating macrophage immunity. However, the potential effect of Wogonin on B cells has not been fully understood. Here, our results showed that Wogonin inhibited IL-10 secretion in B cells. When purified B cells were activated by lipopolysaccharide (LPS) in vitro, the amount of IL-10 production in supernatant was decreased by W

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Wu, Qiongli, Shujuan Xie, Yinhong Zhu, et al. "Wogonin Strengthens the Therapeutic Effects of Mesenchymal Stem Cells in DSS-Induced Colitis via Promoting IL-10 Production." Oxidative Medicine and Cellular Longevity 2021 (June 17, 2021): 1–14. http://dx.doi.org/10.1155/2021/5527935.

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Inflammatory bowel diseases (IBD) are prevalent and debilitating diseases; their clinical remedy is desperately unmet. Mesenchymal stem cells (MSCs) are pluripotent stem cells with multiple immunomodulatory effects, which are attributed to their efficacy in the IBD rodent model. Optimization of MSC regimes in IBD is a crucial step for their further clinical application. Wogonin is a flavonoid-like compound, which showed extensive immunomodulatory and adjuvant effects. This research is aimed at investigating whether and how Wogonin boosted the therapeutic efficiency of MSCs on DSS-induced colit

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Wu, Xue, Fei Wang, Guohua Xia, Yanping Chen, and Baoan Chen. "Influence of Adriamycin and Wogonin on the Expression of Mir-155 in Burrkit Lymphoma in Vitro." Blood 124, no. 21 (2014): 5240. http://dx.doi.org/10.1182/blood.v124.21.5240.5240.

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Abstract Objective: In this study, we investigated the influence of adriamycin and wogonin to the expression of miR-155 in Burrkit lymphoma in vitro. We focused on exploring the efficiency and pathway of wogonin to induce the apoptosis of lymphoma cells through the transcription and translation level of miR-155 compared with ADM and seeking for the evidence of the synergistic effect between wogonin and ADM. Methods: (1) Use drugs to interfere the growth of the Raji cells (Adriamycin (ADM, chemical name:doxorubicin), wogonin, ADM+wogonin), observe the cells through the microscope. (2) The apopt

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Fu, Rong, Qinglong Guo, Yan Chen, Huihui Song та Baoan Chen. "Wogonin Inhibits Angiogenesis Via a c-Myc/Hif-1α–dependent Pathway in Multiple Myeloma". Blood 124, № 21 (2014): 5238. http://dx.doi.org/10.1182/blood.v124.21.5238.5238.

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Abstract Wogonin, a plant-derived flavone, has been shown to inhibit tumor angiogenesis. Angiogenesis is associated with multiple myeloma (MM) progression. However, the mechanisms that Wogonin inhibits angiogenesis in MM microenvironment are not well known. In this study, we investigated Wogonin inhibited tumor angiogenesis that correlated with the inhibition the secretion of vascular endothelial growth factor (VEGF) in MM cells. The c-Myc/Hif-1α–dependent pathway was essential to regulate MM cell-mediated angiogenesis and contributed to tumor growth. Wogonin inhibited c-Myc activation and dow

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Dissertations / Theses on the topic "Wogonin"

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Ding, Jie [Verfasser], and Peter [Akademischer Betreuer] Angel. "Mechanism of Wogonin-mediated sensitization of HTLV-1-associated ATL cells to TRAIL-induced apoptosis / Jie Ding ; Betreuer: Peter Angel." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/117922924X/34.

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Zhang, Wogong [Verfasser], and Jörg [Akademischer Betreuer] Schulze. "Realization of silicon-based monolithic E-band IMPATT-transmitter and Schottky-receiver for wireless applications / Wogong Zhang ; Betreuer: Jörg Schulze." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2019. http://d-nb.info/1197613102/34.

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Chang, Chia-Chen, and 張嘉真. "Biopharmaceutical Studies of Wogonin in Rabbits." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/95824993493780673277.

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碩士<br>中國醫藥學院<br>中國藥學研究所<br>84<br>Wogonin, an active constituent isolated from the root of Scutellaria baicalensis Georgi (Woogon), a frequently use herb in China, possesses antiinflammatory, antispasmodic and lipid- lowering effect. In this study, the pharmacokinetics and bioavailability of wogonin in rabbits were evaluated.A simple high-performance liquid chromatographic method was self- developed for the determination of wogonin in plasma samples.The pharmacokinetics of wogonin in the rab

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Chiu, Wei-Ming, and 邱韋銘. "Syntheses of Wogonin、Oroxylin A and PD98059." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/kf8v5b.

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碩士<br>國立東華大學<br>化學系<br>96<br>Flavonoids such as wogonin and oroxylin A performed potent anti-free radical activity, anti-inflammation, anti-lipid peroxidation, and inhibition of tumor cell growth. Wogonin was isolated from Scutellaria baicalensis Georgi, and found can induce cell apoptosis. In addition, oroxylin A effectively induces the vasodilatation to prevent or alleviate the hypertention. One of the flavonoids, PD98059 selectively blocks the activity of MAP kinase kinase (MAPKK), therefore inhibits the activation of MAP kinase (MAPK) and cell growth. Furthermore, another study found

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Lay, Ing-Shiow, and 賴英秀. "Effect of Chrysin and Wogonin on the Gene Regulation of." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/18174817957510605371.

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Shyu, Chi-Chuo, and 徐綺灼. "Effects of Baicalein and Wogonin on Chemoprevention and Xenobiotic Interactions." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/96081349460276154452.

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碩士<br>國立陽明大學<br>藥理學研究所<br>88<br>Baicalein and wogonin, the main bioactive flavonoids present in Scutellaria baicalensis, have been commonly used in traditional Chinese medicine. Previous reports have demonstrated that oral treatment of rat with crude extract of Scutellaria baicalensis could affect cytochrome P450 (CYP) and intraperitoneal treatment of rats with baicalein and wogonin showed hepatoprotective effects against CCl4 and galactosamine. Therefore, effects of baicalein and wogonin on the gentoxicities of carcinogens and drug-metabolizing enzymes were studied. In vitro, baicalein and wo

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Lin, Chiu-Mei, and 林秋梅. "Inhibitory Effects of Wogonin and Chrysin on Inflammation-stimulated Angiogenesis." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/27072357721909907527.

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博士<br>國立陽明大學<br>傳統醫藥學研究所<br>94<br>Angiogenesis plays an important role in many human disorders, such as tumor formation and myocardial infarction. In angiogenesis, vascular endothelial growth factor (VEGF) plays a central role and present in response to inflammation, shear stress, and hypoxia. VEGF is involved in the endothelial cell proliferation, motility, and vascular permeability through the binding with the tyrosine kinase receptors (VEGFR-1 and VEGFR-2) expressed in endothelial cells. Several transcription factors, including STAT3, have been shown to up-regulate VEGF gene expression in d

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Lee, Yu-Lun, and 李育綸. "Study of the Interaction between Wogonin and Benzo[a]pyrene." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/20264652165833475263.

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碩士<br>國立陽明大學<br>口腔生物研究所<br>98<br>Oral cells can be exposed to polycyclic aromatic hydrocarbons (PAHs) through charcoal grilled food or cigarette smoke. PAHs are widely distributed environmental contaminants. The PAH, benzo[a]pyrene has been demonstrated to cause carcinogenic, mutagenic, cytotoxic, and teratogenic effects in various animal species and tissues.. Through the activation of aryl hydrocarbon receptors (AhR) and the following binding of AhR-ligand complex to dioxin response element, benzo[a]pyrene induce the transcription and translation of cytochrome P450 1A (CYP1A). CYP1A occupies

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Huang, Ho-Chun, and 黃鶴群. "INHIBITION OF WOGONIN, RUTIN AND QUERCETIN ON LIPOPOLYSACCHARIDE-INDUCED INFLAMMATORY RESPENOSES." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/27115975123946725934.

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碩士<br>台北醫學院<br>生藥學研究所<br>89<br>Flavonids are major components of natural products and several biological activities have been explored extensively including antioxidant , anti-inflammation and anti-cancer . Our present study indicated that wogonin , rutin and quercetin showed the significant inhibition on Lipopolysaccharide（LPS）-induced inducible nitric oxide synthase（iNOS） and Cyclooxygenase-2 （COX-2）, Prostaglandin（PGE2）production in RAW 264.7 macrophages. As the same part of experiment, wogonin and quercetin inhibited LPS-induced iNOS gene expression and NO production in primary

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Lee, Hsin-Hsueh, and 李欣學. "Neuroprotective Effects of Wogonin, Baicalin and Baicalein in Primary Cultured Central Neurons." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/44069473884404217075.

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碩士<br>台北醫學院<br>生藥學研究所<br>89<br>Neuronal injury in the central nervous system following ischemic insult is now believed to result from excitotoxicity mediated by glutamate receptors, especially the N-methyl-D-aspartic acid (NMDA) receptor. Therefore, attenuation of NMDA receptor activity may provide a neuroprotective effect to ischemia-insulted brain. In this study, polyphenols, anthraquinones and flavonoids were investigated for their effects on neuronal survival. We used the primary cultured neurons isolated from embryonic rat brains. Cultures were subjected to glutamate and NMDA for 24 hour

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Book chapters on the topic "Wogonin"

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Ueng, Yune-Fang, Chi-Chuo Shyu, Tsung-Yun Liu, et al. "Protective Effects of Baicalein and Wogonin against Mutagen-Induced Genotoxicities." In ACS Symposium Series. American Chemical Society, 2003. http://dx.doi.org/10.1021/bk-2003-0859.ch006.

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Renda, Gülin, and Didem Şöhretoğlu. "Wogonin: Advances on Resources, Biosynthetic Pathway, Bioavailability, Bioactivity, and Pharmacology." In Handbook of Dietary Flavonoids. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-030-94753-8_9-1.

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"Wogonin 7-O-glycuronidemethylether." In Natural Compounds. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-0535-1_421.

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"Wogonin (5,7-Dihydroxy-8-methoxyflavone)." In Natural Compounds. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-0535-1_291.

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"Wogonoside (Wogonin-7-O-glucuronide)." In Natural Compounds. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-0535-1_422.

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"Wogonin 5-O-β-D-glucoside." In Natural Compounds. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-0535-1_417.

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"Wogonin 7-O-β-D-glucopyranoside." In Natural Compounds. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-0535-1_433.

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Tung, Bui Thanh, Nguyen Hong Nhung, Ta Thi Thu Hang, and Vu Khanh Linh. "Herbal Medicine and Its Bioactive Compounds for Treatment of Hepatitis B." In Advances in Medical Diagnosis, Treatment, and Care. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-4453-2.ch008.

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Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) which is one of the most serious public health problems in the world. Some common approved drugs bring about dose-dependent adverse effects or drug resistance. Therefore, safe and useful new HBV therapeutics are essential. Medicinal plants have particular benefits to treat HBV-infected patients. Traditional medicines have many bioactive compounds that are effective as antiviral candidates including esculetin, helioxanthin, oxymatrine, epigallocatechin-3-gallate, wogonin, alkaloids, polysaccharides, etc. In this chapter,

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Lu, Chen, Limin Ma, Haozhen Wang, et al. "A Network Pharmacology Study to Explore Mechanism of the Drug Pair of Astragalus-Saposhnikoviae Radix in the Treatment of Allergic Rhinitis." In Computer Methods in Medicine and Health Care. IOS Press, 2021. http://dx.doi.org/10.3233/atde210242.

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Allergic rhinitis (AR) has now become one of the major diseases affecting people’s lives, and Traditional Chinese medicine (TCM) always has good efficacy in clinical treatment. In the present study, we analyzed the most frequently used drug pair of Astragalus-Saposhnikoviae Radix (SR) in prescriptions for the treatment of allergic rhinitis by network pharmacology to reveal the modern pharmacological mechanisms of drug prevention and treatment of the disease. Firstly, the 38 active ingredients with good ADME properties from the Astragalus-SR drug pair were collected from the database, and the c

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Conference papers on the topic "Wogonin"

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Gong, Hai-Yan, Lin-Lin Wang, Cai-Xia Xie, Jing-Wei Lei, Zhi-Hong Chen, and Yan Bai. "The Establishment of the Quantitative Model of Wogonin in Radix Scutellariae." In 2015 International Conference on Medicine and Biopharmaceutical. WORLD SCIENTIFIC, 2016. http://dx.doi.org/10.1142/9789814719810_0138.

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Kim, Hyungkeun, Kwang-Kyun Park, and Won-Yoon Chung. "Abstract 1543: Wogonin suppresses the production of breast cancer-derived osteolytic factors." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1543.

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Бронских, Е. Д., И. А. Орехова, and Т. С. Шебитченко. "STUDY OF THE PROCESSES OF METABOLISM AND ACCUMULATION OF SECONDARY METABOLITES IN TISSUE CULTURE OF SCUTELLARIA BAICALENSIS GEORGI." In Биотехнология в растениеводстве, животноводстве и сельскохозяйственной микробиологии. Crossref, 2021. http://dx.doi.org/10.48397/arriab.2021.21.xxi.071.

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Шлемник байкальский – многолетнее травянистое растение рода Scutellaria семейства Lamiaceae, которое обладает широчайшим спектром биологически активных веществ, ценных для человека [1, 5]. В настоящее временя из S. baicalensis выделено 81 производное флавона [4]. Основные флавоны шлемника: байкалеин, вогонин и их глюкурониды являются физиологически активными компонентами, которые обладают антимикробным, гипотензивным и седативным действием [1]. Baikal skullcap is a perennial herbaceous plant of the genus Scutellaria of the Lamiaceae family, which has the widest range of biologically active sub

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Wang, Chong-Zhi, Jacqueline Somogyi, and Chun-Su Yuan. "Abstract 1975: The mitochondrial pathway in baicalein and wogonin-induced apoptosis in human colorectal cancer cells." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1975.

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Kim, Ji Won, Eun Hye Kim, Jin Young Park, Minsu Kwon, and Jong-Lyel Roh. "Abstract 5454: Wogonin overcomes cisplatin resistance of head and neck cancer by targeting antioxidant defense mechanisms." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5454.

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Qian, Chen, and Rong Hu. "Abstract C99: Wogonin enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by Nrf2 suppression in HepG2 cells." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-c99.

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Yang, Lan, Xuelian Zheng, Yong Lin, and Xia Wang. "Abstract 3724: Wogonin enhances tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo through H2O2-mediated downregulation of X-linked inhibitor of apoptosis protein and cellular inhibitor of apoptosis protein 1 and 2." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3724.

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