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Journal articles on the topic 'Wogonin'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Yamada, Yasunari, Hodaka Saito, Masaya Araki, et al. "Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells." Nutrients 14, no. 19 (2022): 3920. http://dx.doi.org/10.3390/nu14193920.

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Fibroblast growth factor 21 (FGF21), which is mainly synthesized and secreted by the liver, plays a crucial role in systemic glucose and lipid metabolism, ameliorating metabolic diseases. In this study, we screened the WAKANYAKU library derived from medicinal herbs to identify compounds that can activate Fgf21 expression in mouse hepatocyte AML12 cells. We identified Scutellaria baicalensis root extract and one of its components, wogonin, as an activator of Fgf21 expression. Wogonin also enhanced the expression of activating transcription factor 4 (ATF4) by a mechanism other than ER stress. Kn

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Wu, Jin-Yi, Lih-Geeng Chen, Chia-Wen Hu, et al. "Immunotoxicity and Anti-Inflammatory Characterizations of Prenylated Flavonoids—The Lipophilic 7-O-Terpenylated Wogonin." Life 12, no. 12 (2022): 2116. http://dx.doi.org/10.3390/life12122116.

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Wogonin, one of the exceptional bioactive flavonoids found abundant in the roots of Huang-Qin (Scutellaria baicalensis Georgi), is a popular health-preserving Chinese medicine. The therapeutic applications can be expanded by improving its bioavailability. The 7-O-terpenylated wogonin consisting one to three prenyl units are chemically synthesized for increasing lipophilic nature for efficient uptake, and also an attempt in mimicry of naturally scarce terpenylated flavonoids found in limited plant families and bee propolis. Wogonin (W) and its lipophilic nature prenyl wogonin (W5), geranyl wogo

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3

Lin, Chiu-Mei, Yen-Hsu Chen, Jiann-Ruey Ong, Hon-Ping Ma, Kou-Gi Shyu, and Kuan-Jen Bai. "Functional Role of Wogonin in Anti-Angiogenesis." American Journal of Chinese Medicine 40, no. 02 (2012): 415–27. http://dx.doi.org/10.1142/s0192415x12500322.

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Constitutive activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway occurs commonly in cancer cells and endothelial cells, and contributes to angiogenesis. Wogonin is a compound with many biologically relevant properties. We previously reported that wogonin blocked IL-6-induced angiogenesis through suppression of VEGF expression, an important regulator of angiogenesis. However, the pathway involved in the suppressive effect of wogonin on IL-6-induced VEGF has not been completely clarified. This study aimed to investigate the molecular mechanisms pa

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Adibzadeh Sereshgi, Mohammad Mehdi, Ainaz Mashayekhi, and Hasan Norbazargan. "Wogonin Stimulation of Cell Death and Reducing Survivin in MDM-MB231 Breast Tumors." ImmunoRegulation 4, no. 1 (2021): 33–42. http://dx.doi.org/10.32598/immunoregulation.4.1.2.

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Background: Wogonin as a flavonoid compound is known for its anticancer effect through growth control, differentiation, and apoptosis. This study investigates the possible activity of wogonin in inducing cell death of breast tumors MDA-MB231. Materials and Methods: The level of cell proliferation was evaluated by MTT assay. Cycle analysis and the apoptotic rate were assessed by flow cytometry. mRNA level of Bax, Bcl-2, p53, and survivin was evaluated by real-time PCR. Western blot was utilized to assert the relative protein expression. Results: Wogonin inhibits the proliferation of MDA-MB231 o

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Ruibin, Jiang, Jin Bo, Wan Danying, Zhu Chihong, Feng Jianguo, and Gu Linhui. "Therapy Effects of Wogonin on Ovarian Cancer Cells." BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/9381513.

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Background. Wogonin is a plant monoflavonoid and has been reported to induce apoptosis of cancer cells and show inhibitory effect on cancer cell growth. However, the detailed and underlying molecular mechanisms are not elucidated. In this study, we investigated the molecular and biological effects of wogonin in human ovarian A2780 cancer cells. Materials and Methods. We determined the effects of wogonin on the changes of cell cycling and apoptotic responses of cells. Western blot analysis was used to measure the effects of wogonin on protein expressions. Results. Our results showed that treatm

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Sharifi-Rad, Javad, Jesús Herrera-Bravo, Luis A. Salazar, et al. "The Therapeutic Potential of Wogonin Observed in Preclinical Studies." Evidence-Based Complementary and Alternative Medicine 2021 (June 15, 2021): 1–9. http://dx.doi.org/10.1155/2021/9935451.

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Wogonin is a flavonoid found in different plants such as roots of Scutellaria baicalensis Georgi distributed mainly in Asia and Europe. Dried root extracts of S. baicalensis with high content of wogonin, popularly known as “Huang-Qin” or Chinese or baical skullcap, have been used for long time in traditional Chinese medicine. Several health benefits are attributed to wogonin and derivatives showing anti-inflammatory, antiviral, anticancer, and antioxidant effects and more recently antineurodegenerative properties. Preclinical pharmacological activities of wogonin against diverse types of cance

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Fan, Li, Dongbo Qiu, Guo Huang, et al. "Wogonin Suppresses IL-10 Production in B Cells via STAT3 and ERK Signaling Pathway." Journal of Immunology Research 2020 (June 1, 2020): 1–12. http://dx.doi.org/10.1155/2020/3032425.

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Wogonin (5,7-dihydroxy-8-methoxyflavone) is an ingredient of the extracts from Scutellaria baicalensis, which has documented a wide spectrum of anti-inflammatory and antitumor activities, including inhibiting regulatory T cells, regulating effector T cell functions, and mediating macrophage immunity. However, the potential effect of Wogonin on B cells has not been fully understood. Here, our results showed that Wogonin inhibited IL-10 secretion in B cells. When purified B cells were activated by lipopolysaccharide (LPS) in vitro, the amount of IL-10 production in supernatant was decreased by W

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Wu, Qiongli, Shujuan Xie, Yinhong Zhu, et al. "Wogonin Strengthens the Therapeutic Effects of Mesenchymal Stem Cells in DSS-Induced Colitis via Promoting IL-10 Production." Oxidative Medicine and Cellular Longevity 2021 (June 17, 2021): 1–14. http://dx.doi.org/10.1155/2021/5527935.

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Inflammatory bowel diseases (IBD) are prevalent and debilitating diseases; their clinical remedy is desperately unmet. Mesenchymal stem cells (MSCs) are pluripotent stem cells with multiple immunomodulatory effects, which are attributed to their efficacy in the IBD rodent model. Optimization of MSC regimes in IBD is a crucial step for their further clinical application. Wogonin is a flavonoid-like compound, which showed extensive immunomodulatory and adjuvant effects. This research is aimed at investigating whether and how Wogonin boosted the therapeutic efficiency of MSCs on DSS-induced colit

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Wu, Xue, Fei Wang, Guohua Xia, Yanping Chen, and Baoan Chen. "Influence of Adriamycin and Wogonin on the Expression of Mir-155 in Burrkit Lymphoma in Vitro." Blood 124, no. 21 (2014): 5240. http://dx.doi.org/10.1182/blood.v124.21.5240.5240.

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Abstract Objective: In this study, we investigated the influence of adriamycin and wogonin to the expression of miR-155 in Burrkit lymphoma in vitro. We focused on exploring the efficiency and pathway of wogonin to induce the apoptosis of lymphoma cells through the transcription and translation level of miR-155 compared with ADM and seeking for the evidence of the synergistic effect between wogonin and ADM. Methods: (1) Use drugs to interfere the growth of the Raji cells (Adriamycin (ADM, chemical name:doxorubicin), wogonin, ADM+wogonin), observe the cells through the microscope. (2) The apopt

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Fu, Rong, Qinglong Guo, Yan Chen, Huihui Song та Baoan Chen. "Wogonin Inhibits Angiogenesis Via a c-Myc/Hif-1α–dependent Pathway in Multiple Myeloma". Blood 124, № 21 (2014): 5238. http://dx.doi.org/10.1182/blood.v124.21.5238.5238.

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Abstract Wogonin, a plant-derived flavone, has been shown to inhibit tumor angiogenesis. Angiogenesis is associated with multiple myeloma (MM) progression. However, the mechanisms that Wogonin inhibits angiogenesis in MM microenvironment are not well known. In this study, we investigated Wogonin inhibited tumor angiogenesis that correlated with the inhibition the secretion of vascular endothelial growth factor (VEGF) in MM cells. The c-Myc/Hif-1α–dependent pathway was essential to regulate MM cell-mediated angiogenesis and contributed to tumor growth. Wogonin inhibited c-Myc activation and dow

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Tronina, Tomasz, Monika Mrozowska, Agnieszka Bartmańska, Jarosław Popłoński, Sandra Sordon, and Ewa Huszcza. "Simple and Rapid Method for Wogonin Preparation and Its Biotransformation." International Journal of Molecular Sciences 22, no. 16 (2021): 8973. http://dx.doi.org/10.3390/ijms22168973.

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Wogonin is one of the most active flavonoids from Scutellaria baicalensis Georgi (baikal skullcap), widely used in traditional Chinese medicine. It exhibits a broad spectrum of health-promoting and therapeutic activities. Together with baicalein, it is considered to be the one of main active ingredients of Chinese medicines for the management of COVID-19. However, therapeutic use of wogonin may be limited due to low market availability connected with its low content in baikal skullcap and lack of efficient preparative methods for obtaining this compound. Although the amount of wogonin in skull

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Cui, Lidan, Zuomei Zeng, Xinyue Wang, et al. "Deciphering the Mechanism of Wogonin, a Natural Flavonoid, on the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Integrating Network Pharmacology and In Vitro Validation." Current Issues in Molecular Biology 45, no. 1 (2023): 555–70. http://dx.doi.org/10.3390/cimb45010037.

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Wogonin is one of the main active components of Scutellaria baicalensis, which has anti-inflammatory, anti-angiogenesis, and anti-fibrosis effects. Nevertheless, the effect of wogonin on pulmonary hypertension (PH) still lacks systematic research. This study aims to elucidate the potential mechanism of wogonin against PH through network pharmacology and further verify it through biological experiments in pulmonary arterial smooth muscle cells (PASMCs). The potential targets and pathways of wogonin against PH were predicted and analyzed by network pharmacology methods and molecular docking tech

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13

Yang, Li, Hai-wei Zhang, Rong Hu, et al. "Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells." Biochemistry and Cell Biology 87, no. 6 (2009): 933–42. http://dx.doi.org/10.1139/o09-060.

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Wogonin, a naturally occurring flavonoid, has been shown to have tumor therapeutic potential both in vitro and in vivo. To better understand its anticancer mechanism, we examined the effect of wogonin on human cervical carcinoma HeLa cells. In this study, we observed that G1 phase arrest was involved in wogonin-induced growth inhibition in HeLa cells. Over a 24 h exposure of HeLa cells to 90 µmol·L–1 wogonin, the promoters of G1–S transition, including cyclin D1/Cdk4 and pRb, decreased within 12 h and E2F-1 depleted in the nucleus at the same time. As the G1 phase arrest developed, p53 and the

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Li, Jitian, Weifeng Duan, Shuang Chai, et al. "Wogonin, a Bioactive Ingredient from Huangqi Guizhi Formula, Alleviates Discogenic Low Back Pain via Suppressing the Overexpressed NGF in Intervertebral Discs." Mediators of Inflammation 2023 (February 20, 2023): 1–14. http://dx.doi.org/10.1155/2023/4436587.

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Purpose. To investigate whether wogonin, a key bioactive ingredient of Huangqi Guizhi formula (HQGZ formula; a Traditional Chinese Medicine herbal formula) according to network pharmacology analysis, has analgesic effects on discogenic low back pain (LBP) via regulating the nerve growth factor (NGF) in intervertebral discs (IVDs). Methods. The lumbar IVDs of rats were punctured to discogenic LBP, and the therapeutic effect of orally administrated HQGZ for discogenic LBP was investigated by measuring mechanical and cold allodynia and histological analysis. A network pharmacology analysis was co

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15

Khan, Shahzad, and Mohammad A. Kamal. "Can Wogonin be Used in Controlling Diabetic Cardiomyopathy?" Current Pharmaceutical Design 25, no. 19 (2019): 2171–77. http://dx.doi.org/10.2174/1381612825666190708173108.

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<P>Diabetes Mellitus (DM) is now a well-known factor which initiates many metabolic derangements in various tissues and organs including liver, muscle, pancreas, adipose tissue, cardiovascular and nervous system. Cardiovascular complications are the most crucial , and their effects are so intensive that their derangement leads to cardiac failure even in the absence of ischemic heart diseases. This entity of cardiac pathology in DM is often regarded as diabetic cardiomyopathy (DCM). Recently, many plant-derived drugs have been tested to control and alleviate DCM. Wogonin is one of the dru

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Kim, Kyeong Ah, Joo Hyun Jung, Yun Sook Choi, Gyu Kang, and Seon Tae Kim. "Anti-inflammatory effect of wogonin on allergic responses in ovalbumin-induced allergic rhinitis in the mouse." Allergy & Rhinology 9 (January 2018): 215265671876414. http://dx.doi.org/10.1177/2152656718764145.

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Background Wogonin is commonly used for the treatment of allergic diseases. However, neither its precise effect in preventing allergic rhinitis (AR) nor its mechanism of action are known. Objectives In this study, the effect of wogonin on allergic responses in ovalbumin (OVA) induced AR was investigated in mice. Methods BALB/c mice were sensitized with intraperitoneal (i.p.) OVA and then challenged intranasally with OVA. Wogonin (10 and 30 mg/kg) was given to the treatment groups, and the effect of wogonin on the release of allergic inflammatory mediators, specifically OVA-specific immunoglobu

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Butt, Ghazala, Ulku Ozbey, Durr-e.-shahwar Malik, Rukset Attar, Lara Youssef, and Ammad Ahmad Farooqi. "Regulation of cell signaling pathways by Wogonin in different cancers: Mechanistic review." Cellular and Molecular Biology 67, no. 2 (2021): 1–7. http://dx.doi.org/10.14715/cmb/2021.67.2.1.

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Natural products have historically been invaluable as a premium source of therapeutic agents. Recent advancements in genomics and structural biology have portrayed a high-resolution landscape of the diversity of proteins targeted by pharmacologically active products from natural sources. Natural product research has generated valuable wealth of information and cutting-edge research-works have leveraged our conceptual knowledge altogether to a new level. Wogonin (5,7-dihydroxy-8-methoxyflavone) is an O-methylated flavone and has attracted noteworthy appreciation because of its ability to pharma

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Khan, Shahzad, and Mohammad A. Kamal. "Wogonin Alleviates Hyperglycemia Through Increased Glucose Entry into Cells Via AKT/GLUT4 Pathway." Current Pharmaceutical Design 25, no. 23 (2019): 2602–6. http://dx.doi.org/10.2174/1381612825666190722115410.

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: Insulin resistance and type 2 Diabetes mellitus resulting in chronic hyperglycemia is a major health problem in the modern world. Many drugs have been tested to control hyperglycemia which is believed to be the main factor behind many of the diabetes-related late-term complications. Wogonin is a famous herbal medicine which has been shown to be effective in controlling diabetes and its complications. In our previous work, we showed that wogonin is beneficial in many ways in controlling diabetic cardiomyopathy. In this review, we mainly explained wogonin anti-hyperglycemic property through AK

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Qi, Qiurong, Ying Li, Mengbing Ding, et al. "Wogonin Inhibits Apoptosis and Necroptosis Induced by Nephropathogenic Infectious Bronchitis Virus in Chicken Renal Tubular Epithelial Cells." International Journal of Molecular Sciences 25, no. 15 (2024): 8194. http://dx.doi.org/10.3390/ijms25158194.

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NIBV is an acute and highly contagious virus that has a major impact on the poultry industry. Wogonin, as a flavonoid drug, has antiviral effects, but there have been no reports indicating its role in renal injury caused by NIBV infection. The aim of this study is to investigate the antiviral effect of wogonin against NIBV. Renal tubular epithelial cells were isolated and cultured, and divided into four groups: Con, Con+Wog, NIBV and NIBV+Wog. We found that wogonin significantly inhibited the copy number of NIBV and significantly alleviated NIBV-induced cell apoptosis and necrosis. Moreover, w

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Hirata, Y., M. Tatsu, C. Amano, et al. "Synergistic Antitumor Effect of Genitinib (Iressa®) with Flavonoids from the Scutellaria baicalensis Root on the Non-Small Cell Lung Cells." Open Plant Science Journal 10, no. 1 (2017): 62–69. http://dx.doi.org/10.2174/1874294701710010062.

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Background: As was reported, gefitinib (Iressa®) showed a strong growth inhibitory effect on non-small-cell lung cancer PC-9 cells with mutant EGFR, but did not so much on A549 cells with wild-type EGFR. Observation: We here demonstrated by isobolograms and combination index analyses that the paired combinations of gefitinib with flavonoids from Wogon (Scutellaria baicalensis root): wogonin, oroxylin A and chrysin exerted synergistic anti-tumor effects against A549 cells. Result: The cell cycle analyses revealed that the combination of gefitinib and oroxylin A in A549 cells induced more apopto

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Sukmawati, Riska, Dwi Guntoro, and Ahmad Junaedi. "PENGUJIAN SIFAT BIOHERBISIDA EKSTRAK TUMBUHAN Tetracera indica L. Merr DAN SENYAWA WOGONIN PADA GULMA UJI DAN TANAMAN." Media Pertanian 9, no. 2 (2024): 74–79. https://doi.org/10.37058/mp.v9i2.12059.

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Tumbuhan T. indica memiliki zat alelokimia yang dapat berperan sebagai bioherbisida. Salah satu zat alelokimia yang diduga mampu menghambat perkecambahan gulma yaitu senyawa wogonin. Penelitian dilaksanakan di Laboratorium Penyimpanan dan Pengujian Mutu Benih Fakutas Pertanian IPB pada bulan Oktober 2018 sampai dengan Juni 2019. Penelitian menggunakan rancangan acak lengkap (RAL) dengan tiga perlakuan yaitu senyawa wogonin konsentrasi 80 ppm, ekstrak T. indica 13.75 ppm dan kontrol dengan empat ulangan dihasilkan 36 satuan unit percobaan disusun pada cawan petri kemudian diberi alas satu lemba

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Baumann, Sven, Stefanie C. Fas, Marco Giaisi та ін. "Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCγ1- and Ca2+-dependent apoptosis". Blood 111, № 4 (2008): 2354–63. http://dx.doi.org/10.1182/blood-2007-06-096198.

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Herbs have successfully been used in traditional Chinese medicine for centuries. However, their curative mechanisms remain largely unknown. In this study, we show that Wogonin, derived from the traditional Chinese medicine Huang-Qin (Scutellaria baicalensis Georgi), induces apoptosis in malignant T cells in vitro and suppresses growth of human T-cell leukemia xenografts in vivo. Importantly, Wogonin shows almost no toxicity on T lymphocytes from healthy donors. Wogonin induces prolonged activation of PLCγ1 via H2O2 signaling in malignant T cells, which leads to sustained elevation of cytosolic

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Jiang, Ai, Haibin Ding, and Yong Fu. "Wogonin Inhibits Nasopharyngeal Carcinoma Cells." Current Topics in Nutraceutical Research 22, no. 1 (2023): 64–73. http://dx.doi.org/10.37290/ctnr2641-452x.22:64-73.

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Wogonin, an active constituent of Scutellaria baicalensis Georgi, exhibits antitumor potential. This study aimed to study the effect and mechanism of wogonin on the apoptosis and proliferation of nasopharyngeal carcinoma cells. Methyl thiazolyl tetrazolium-based cell viability, flow cytometry, and Transwell assays were conducted to assess the cells’ malignant behaviors, and western blot was utilized to assess protein expression. The results indicated that wogonin inhibited nasopharyngeal carcinoma cell proliferation, migration, invasion, and elevated cell apoptosis in a dose-dependent way. Bes

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Huang, Ding-Siang, Yu-Chen Yu, Chung-Hsin Wu, and Jung-Yaw Lin. "Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/3545169.

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One of the pathogenic systems of Alzheimer’s disease (AD) is the formation ofβ-amyloid plaques in the brains of patients, and amyloidogenic activity becomes one of the therapeutic targets. Here, we report wogonin, one of the major active constituting components inScutellaria baicalensis, which has the neuroprotective effects on amyloid-βpeptides- (Aβ-) induced toxicity. Oral wogonin treatment improved the performance of triple transgenic AD mice (h-APPswe, h-Tau P301L, and h-PS1 M146V) on the Morris water maze, Y-maze, and novel object recognition. Furthermore, wogonin activated the neurite ou

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Wang, Shiwei, Yuqi Feng, Xiaofeng Han, et al. "Inhibition of Virulence Factors and Biofilm Formation by Wogonin Attenuates Pathogenicity of Pseudomonas aeruginosa PAO1 via Targeting pqs Quorum-Sensing System." International Journal of Molecular Sciences 22, no. 23 (2021): 12699. http://dx.doi.org/10.3390/ijms222312699.

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Pseudomonas aeruginosa, an important opportunistic pathogen, is capable of producing various virulence factors and forming biofilm that are regulated by quorum sensing (QS). It is known that targeting virulence factor production and biofilm formation instead of exerting selective pressure on growth such as conventional antibiotics can reduce multidrug resistance in bacteria. Therefore, many quorum-sensing inhibitors (QSIs) have been developed to prevent or treat this bacterial infection. In this study, wogonin, as an active ingredient from Agrimonia pilosa, was found to be able to inhibit QS s

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Yin, Xiaoling, Qianqi Liu, and Dongni Wang. "Wogonin Ameliorates Neuronal Injury Induced by Obesity Via Inactivation of the Mitogen Activated Protein Kinase Pathway." Current Topics in Nutraceutical Research 20, no. 2 (2021): 306–12. http://dx.doi.org/10.37290/ctnr2641-452x.20:306-312.

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Metabolic syndromes and type 2 diabetes mellitus are major metabolic complications of obesity. These metabolic complications are implicated in the pathogenesis of Alzheimer’s disease, vascular dementia, and mild cognitive impairment. Wogonin protects against ischemia-induced neurodegeneration, exerts neuroprotective effect against amyloid betainduced toxicity, and ameliorates cognitive dysfunction. However, the role of wogonin in obesity associated neuronal injury and a cognitive change has not yet been examined. To this end, using a high fat diet induced obese mouse model, we have examined th

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Rahmawati, Devi, and Dewi Ratih Tirto Sari. "Komparasi Senyawa Wogonin dan Rhinacanthin C Rhinacanthus nasutus Terhadap Candida albicans Secara In Silico." Jurnal Farmasi Tinctura 6, no. 1 (2025): 29–39. https://doi.org/10.35316/tinctura.v6i1.6097.

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Candida albicans merupakan mikroorganisme patogen penyebab candidiasis pada kulit. Rhinacanthus nasutus merupakan salah satu tumbuhan liar yang banyak digunakan untuk mengobati penyakit kulit, dan dilaporkan memiliki aktivitas antibakteri dan antifungi. Namun, mekanisme senyawa yang terkandung dalam R. nasutus terhadap patogen jamur, khususnya Candida albicans masih terbatas. Oleh karena itu, penelitian ini bertujuan untuk mengidentifikasi mekanisme penghambatan virulensi Candida albicans oleh senyawa rhinacantin C dan wogonin secara in silico. Senyawa R. nasutus wogonin (ID5281703) dan Rhinac

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Song, Ying-Chyi, and Hung-Rong Yen. "The Immunomodulatory Effects and Mechanism of Wogonin for the Treatment of Multiple Sclerosis in a Murine Experimental Autoimmune Encephalomyelitis Model." Journal of Immunology 212, no. 1_Supplement (2024): 0433_4446. http://dx.doi.org/10.4049/jimmunol.212.supp.0433.4446.

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Abstract Multiple sclerosis (MS) stands out as the most prevalent inflammatory autoimmune disease affecting the central nervous system (CNS). The primary driver of MS involves myelin-specific autoreactive T cells that infiltrate the CNS, initiating attacks on myelinated axons and triggering neuroinflammatory responses. Wogonin, a flavonoid, exhibits pharmacologic properties, including neuroprotective, anticancer, antiviral, anti-inflammatory, and anti-oxyradical effects. Our study demonstrates that wogonin significantly suppresses TLR-dependent DC activation, migration, and the expression of a

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Qing, Yingjie, Hui Li, Yunzi Zhao, et al. "One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence." Oxidative Medicine and Cellular Longevity 2021 (September 21, 2021): 1–20. http://dx.doi.org/10.1155/2021/5529518.

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T-cell malignancies are still difficult to treat due to a paucity of plans that target critical dependencies. Drug-induced cellular senescence provides a permanent cell cycle arrest during tumorigenesis and cancer development, particularly when combined with senolytics to promote apoptosis of senescent cells, which is an innovation for cancer therapy. Here, our research found that wogonin, a well-known natural flavonoid compound, not only had a potential to inhibit cell growth and proliferation but also induced cellular senescence in T-cell malignancies with nonlethal concentration. Transcript

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Takagi, Rie, Masaaki Kawano, Kazuyuki Nakagome, et al. "Wogonin Attenuates Ovalbumin Antigen-Induced Neutrophilic Airway Inflammation by Inhibiting Th17 Differentiation." International Journal of Inflammation 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/571508.

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Allergic airway inflammation is generally considered to be a Th2-type immune response. Recent studies, however, have demonstrated that Th17-type immune responses also play important roles in this process, particularly in the pathogenesis of neutrophilic airway inflammation, a hallmark of severe asthma. We scrutinized several Kampo extracts that reportedly exhibit anti-inflammatory activity by usingin vitrodifferentiation system of human and mouse naïve T cells. We found that hange-shashin-to (HST) and oren-gedoku-to (OGT) possess inhibitory activity for Th17 responsesin vitro. Indeed, wogonin

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Dürr, Claudia, Bola Hanna, Fabienne McClanahan, et al. "The Flavonoid Wogonin Reduces CLL Cell Survival in Vitro and Leukemia Development in Eµ-TCL1 Mice By Targeting Aberrant TNF Receptor Signaling." Blood 124, no. 21 (2014): 1966. http://dx.doi.org/10.1182/blood.v124.21.1966.1966.

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Abstract The importance of the tumor microenvironment in the development of B-cell chronic lymphocytic lekuemia (CLL) is now widely accepted. Previous studies within our and other groups revealed the establishment of an inflammatory milieu in CLL characterized by enhanced expression and secretion of several cytokines and their receptors. Using 250 CLL serum samples and 50 age-matched controls, we found significantly increased levels of the TNFα receptors TNFR1 and TNFR2 in the patients that positively correlated with an adverse clinical outcome. Based on these findings we aimed to investigate

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Jiang, Xia, Youhong Li, Lei Jiang, Renzhi Pei, Jie Jin, and Ying Lu. "Wogonin Induces Apoptosis of Acute Myeloid Leukemia Cells through PI3K/Akt Pathway and Synergies with Venetoclax." Blood 144, Supplement 1 (2024): 5803. https://doi.org/10.1182/blood-2024-204697.

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Background:Acute myeloid leukemia (AML) is a highly aggressive and heterogeneous hematological malignancy. Although 80% of patients with AML achieve complete remission after receiving standard chemotherapy, most relapse or die from treatment-related complications, and the overall prognosis remains less than 30%. Wogonin is a kind of natural flavonoid with anti-inflammatory, anti-tumor and other biological activities which could kill tumor cells by inducing cell cycle arrest. Venetoclax is a highly selective BCL-2 inhibitor that is currently approved for the treatment of chronic lymphocytic leu

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Radajewska, Anna, Helena Moreira, Dorota Bęben, et al. "Combination of Irinotecan and Melatonin with the Natural Compounds Wogonin and Celastrol for Colon Cancer Treatment." International Journal of Molecular Sciences 24, no. 11 (2023): 9544. http://dx.doi.org/10.3390/ijms24119544.

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Colorectal cancers are one of the leading cancers worldwide and are known for their high potential for metastasis and resistance to therapy. The aim of this study was to investigate the effect of various combination therapies of irinotecan with melatonin, wogonin, and celastrol on drug-sensitive colon cancer cells (LOVO cell line) and doxorubicin-resistant colon cancer stem-like cells (LOVO/DX cell subline). Melatonin is a hormone synthesized in the pineal gland and is responsible for circadian rhythm. Wogonin and celastrol are natural compounds previously used in traditional Chinese medicine.

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Dong, Wei, Xin Wang, Zemei Ge, Fang He, and Runtao Li. "Efficient Synthesis of Wogonin." Chinese Journal of Organic Chemistry 40, no. 6 (2020): 1725. http://dx.doi.org/10.6023/cjoc202001033.

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Pal, Mahesh, Harsha Joshi, V. P. Kapoor, P. Pushpangadan, and Leena Chaurasia. "Antifungal activity of wogonin." Phytotherapy Research 17, no. 10 (2003): 1215–16. http://dx.doi.org/10.1002/ptr.1327.

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Fas, Stefanie C., Sven Baumann, Jia Yun Zhu та ін. "Wogonin sensitizes resistant malignant cells to TNFα- and TRAIL-induced apoptosis". Blood 108, № 12 (2006): 3700–3706. http://dx.doi.org/10.1182/blood-2006-03-011973.

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AbstractTNFα has previously been used in anticancer therapy. However, the therapeutic application of TNFα was largely limited due to its general toxicity and the fact that it activates the NF-κB–family transcription factors, which are proinflammatory and antiapoptotic. To overcome this problem in vitro, specific NF-κB inhibitors or transcription or protein synthesis inhibitors such as actinomycin D and cycloheximide are usually used in combination to increase TNFα killing of tumor cells. However, these agents also cause harmful side effects in vivo. We show here that wogonin, derived from the

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De Grano, Ruel Valerio Robles, Elena V. Vashchenko, Madiha Nisar, Herman H. Y. Sung, Valerii V. Vashchenko, and Ian D. Williams. "Crystal structures of the flavonoid Oroxylin A and the regioisomers Negletein and Wogonin." Acta Crystallographica Section C Structural Chemistry 76, no. 5 (2020): 490–99. http://dx.doi.org/10.1107/s2053229620005550.

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The flavonoid Oroxylin A (6-methoxychrysin or 5,7-dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one, C16H12O5) and its regioisomers are of increasing interest for a variety of bioactive functions and their pharmaceutical formulation is of importance. Previous difficulties in the separation and misidentification of Oroxylin A from its regioisomers Wogonin (8-methoxychrysin or 5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one) and Negletein (5,6-dihydroxy-7-methoxyflavone or 5,6-dihydroxy-7-methoxy-2-phenyl-4H-chromen-4-one) render its full structural and powder X-ray characterization highly desirab

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Gao, Jiayu, Alberto Sanchez-Medina, Barbara A. Pendry, Michael J. Hughes, Geoffrey P. Webb, and Olivia Corcoran. "Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures." Journal of Pharmacy & Pharmaceutical Sciences 11, no. 1 (2008): 77. http://dx.doi.org/10.18433/j39g6v.

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Purpose: To compare the flavonoid biomarker content (baicalin, baicalein and wogonin) of eleven commercial tinctures derived from Scutellaria lateriflora aerial parts (n=7) and Scutellaria baicalensis root (n=4). S. lateriflora tinctures are used in by western herbal practitioners to treat anxiety whereas S. baicalensis tinctures are used to treat inflammatory disease. Methods: Baicalin and baicalein were purchased from Aldrich Chemical Co. and Wogonin was purchased from ChromaDex. The internal standard (4-hydroxybenzoic acid) was obtained from Acros Organics. The column used was a Luna C18, 5

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Zhang, Qiushan, Jin Shao, Tong Zhao, Lei He, Huiping Ma, and Linlin Jing. "The Role of C-8 OH on the Antioxidant Activity of Norwogonin and Isowogonin." Natural Product Communications 15, no. 5 (2020): 1934578X2092488. http://dx.doi.org/10.1177/1934578x20924887.

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In the present study, the antioxidant property of 4 flavones (moslosooflavone, wogonin, isowogonin, and norwogonin) was evaluated using 6 different assays: 1,1-diphenyl-2-picrylhydrazyl (DPPH·), superoxide (O2 •−), and nitric oxide (NO) radical scavenging assays, ferrous iron chelation, reducing power, and total antioxidant capacity. The 4 flavones exhibited antioxidant activities with decreasing order as norwogonin > isowogonin >> wogonin> moslosooflavone. The present results demonstrated that norwogonin and isowogonin exhibited excellent antioxidant activity, which was mainly bas

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Khan, Shahzad. "Wogonin and Alleviation of Hyperglycemia via Inhibition of DAG Mediated PKC Expression. A Brief Insight." Protein & Peptide Letters 28, no. 12 (2021): 1365–71. http://dx.doi.org/10.2174/0929866528666211027113349.

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Abstract: Protein kinase C (PKC) is a family of protein kinase enzymes that can phosphorylate other proteins and influence their functions, such as signal transduction, cell survival, and death. Increased diacylglycerol (DAG) concentrations, which are typically observed raised in hyperglycemic situations such as diabetes mellitus, can also activate PKC enzymes (DM). On the other hand, PKC isomers have been shown to play an essential role in diabetes and many hyperglycemic complications, most importantly atherosclerosis and diabetic cardiomyopathy (DCM). As a result, blocking PKC activation via

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李, 忠鑫. "Review of Pharmacological Effects of Wogonin." Traditional Chinese Medicine 13, no. 11 (2024): 3039–46. http://dx.doi.org/10.12677/tcm.2024.1311448.

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Chirumbolo, Salvatore. "Anticancer properties of the flavone wogonin." Toxicology 314, no. 1 (2013): 60–64. http://dx.doi.org/10.1016/j.tox.2013.08.016.

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Liu, Yongchun, Wenying He, Wenhua Gao, Zhide Hu, and Xingguo Chen. "Binding of wogonin to human gammaglobulin." International Journal of Biological Macromolecules 37, no. 1-2 (2005): 1–11. http://dx.doi.org/10.1016/j.ijbiomac.2005.04.005.

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Tian, Jianniao, Jiaqin Liu, Jianping Xie, Xiaojun Yao, Zhide Hu, and Xinguo Chen. "Binding of wogonin to human serum albumin: a common binding site of wogonin in subdomain IIA." Journal of Photochemistry and Photobiology B: Biology 74, no. 1 (2004): 39–45. http://dx.doi.org/10.1016/j.jphotobiol.2004.01.001.

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Ji, Yeongseon, Jin Han, Nayoung Lee та ін. "Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation". Molecules 25, № 21 (2020): 5087. http://dx.doi.org/10.3390/molecules25215087.

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Amyloid beta (Aβ) peptide, one of the most important pathogenic traits of Alzheimer’s disease (AD), invokes a cascade of oxidative damage and eventually leads to neuronal death. In the present study, baicalein, wogonin, and oroxylin A, main active flavones in Scutellaria baicalensis, were evaluated for their neuroprotective effects against Aβ25–35-stimulated damage. All tested compounds decreased Aβ25–35-induced ROS generation and cell cycle arrest. In particular, baicalein exhibited the strongest antioxidant activity. In addition, these compounds suppressed apoptosis by attenuating mitochondr

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Wang, Qian, Rong Shi, Yan Dai, et al. "Mechanism in the existent difference in form of wogonin/wogonoside between plasma and intestine/liver in rats." RSC Advances 8, no. 7 (2018): 3364–73. http://dx.doi.org/10.1039/c7ra08270c.

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Shia, Chi-Sheng, Yu-Chi Hou, Shin-Hun Juang, et al. "Metabolism and Pharmacokinetics of San-Huang-Xie-Xin-Tang, a Polyphenol-Rich Chinese Medicine Formula, in Rats andEx-VivoAntioxidant Activity." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–9. http://dx.doi.org/10.1093/ecam/nep124.

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San-Huang-Xie-Xin-Tang (SHXXT), a widely used Chinese herbal formula, consists of rhizomes ofRheum officinale, roots ofScutellaria baicalensisand rhizomes ofCoptis chinesis. This study investigated the metabolism and pharmacokinetics of polyphenols in SHXXT, including baicalin, baicalein, wogonin, emodin, aloe-emodin, rhein and chrysophanol. The quantitation methods of SHXXT decoction and rat serum using high performance liquid chromatography were developed and validated in this study. After oral administration of SHXXT decoction to rats, the parent forms of various constituents and their conj

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Yu, Chung-Ping, Chi-Sheng Shia, Shang-Yuan Tsai, and Yu-Chi Hou. "Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/308018.

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Gegen-Qinlian-Tang (GQT), a popular Chinese medicine prescription, consists of Puerariae Radix, Scutellariae Radix, Coptidis Rhizoma, and Glycyrrhizae Radix. This study investigated the pharmacokinetics of GQT in rats and compared the bioavailability between two dosage forms, that is, traditional decoction (TD) and concentrated powder (CP). Rats were given TD and CP of GQT in a crossover design, and blood samples were withdrawn at predetermined time points. The quantitation methods of ten constituents in two dosage forms of GQT and in serum specimen using HPLC were developed and validated in t

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Yeon Kwon, Do, Haeng Hoon Kim, Jong Seok Park, Sang Un Park, and Nam Il Park. "Production of Bacalin, Bacalein and Wogonin in Hairy Root Culture of American Skullcap (Scutellaria lateriflora)by Auxin Treatment." Biosciences, Biotechnology Research Asia 14, no. 2 (2017): 673–77. http://dx.doi.org/10.13005/bbra/2493.

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ABSTRACT: The hairy root culture of American Skullcap (Scutellaria lateriflora) was studied to investigate the biomass and flavonoids content (baicalin, baicalein and wogonin) in response of various auxin concentrations.The growth rates of the hairy roots varied significantly only at IBA 0.1 mg/L and for all other auxin treatments did not vary significantly. The biomass of hairy roots was 8% higher when treated with IBA 0.1 mg/L and biomass was almost similar and slightly lower levels when treated with various IAA concentration and NAA, respectively. However, the auxins treatments responsed po

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Chow, Jyh-Ming, Guan-Cheng Huang, Shing-Chuan Shen, Chin-Yen Wu, Cheng-Wei Lin, and Yen-Chou Chen. "Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells." Journal of Cellular Biochemistry 103, no. 5 (2008): 1394–404. http://dx.doi.org/10.1002/jcb.21528.

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