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Vendra, Sruthi* Bonthu Bhavani satya prasad. "Electricity Can Renovate Even the Worst Type of Wounds." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1066–75. https://doi.org/10.5281/zenodo.14871131.
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Researchers from Chalmers Insitute of Technology (CTH) and the University of Freiburg have proposed an interesting technique that enables chronic wounds to heal faster than ever. Medical conditions like diabetes, cancer, disturbed blood circulation, and spinal injuries can sometimes impair our body’s natural ability to heal wounds. Patients who live with such conditions often experience wounds that don’t heal.These unrepaired chronic wounds become a source of infection and sometimes even lead to amputations, making patients’ lives very difficult. In their latest study, the researchers claim to heal chronic wounds three times faster using electric current showing majority of improvement.
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Ferawati, Ferawati. "APLIKASI PERAWATAN LUKA DENGAN MENGGUNAKAN ENZYMATIK THERAPY: ALOE VERA DALAM MANAJEMEN LUKA DIABETES." Journal of Health Sciences 11, no. 2 (2018): 121–29. http://dx.doi.org/10.33086/jhs.v11i2.104.
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Introduction:Diabetes mellitus is a metabolic disease group will facilitate the occurrence of diabetic foot wounds. To prevent the complications of diabetic wound that lasts longer and prevents the worse then takes care of wounds in diabetics. Latest wound care techniques are already using a bandage. The principle of modern wound treatment products is to maintain and keep the environment humid permanent cuts to facilitate the process of wound healing, maintaining the loss of fluid networks and cell death.
 Objective: this study aimed to find out how the application methods of wound care using the enzymatik therapy: aloe vera in diabetic wound management.
 Methods: the study was qualitative research with approach case studies, a number of participants 1 person: patients with diabetic wounds, treated for 9 days using the method of modern wound care therapy: enzymatic reactions with the use of aloe vera. Participants selected by the method of purposive sampling. Data collection using observation and interviews, data analysis using the method of explanation building.
 Results: the results of the research there are 4 themes, namely the study of the wound, the kind of wrap used, how to wound care, influence on the wound. The study of the wound using Bates-Jensen Wound Assessment Tool, a type of bandage used are enzymatic reactions therapy: aloe vera and ointments wound, how to wound care using approaches TIME management, and reduced effect on wound care the size of the cuts, epitelisasi, granulation wounds and the amount of fluid that appears.
 Conclusion: the method of Application wound care therapy: enzymatic reactions using aloe vera on wounds of diabetes affect the dwindling size of cuts, epitelisasi and granulation wound. Health care personnel are advised to use enzymatik therapy: aloe vera in the treatment of diabetic wounds as diabetic wound management integrated with attention to the principles of wound care using the latest evidence based nursing
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Zhang, Yazhou, Steve A. McClain, Hsi-Ming Lee, et al. "A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies." Journal of Diabetes Research 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/5782904.
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Introduction. Impaired wound-healing in diabetics can lead to life-threatening complications, such as limb amputation, associated in part with excessive matrix metalloproteinase- (MMP-) mediated degradation of collagen and other matrix constituents. In the current study, a novel triketonic chemically modified curcumin, CMC2.24, was tested for efficacy in healing of standardized skin wounds in streptozotocin-induced diabetic rats. Initially, CMC2.24 was daily applied topically at 1% or 3% concentrations or administered systemically (oral intubation; 30 mg/kg); controls received vehicle treatment only. Over 7 days, the diabetics exhibited impaired wound closure, assessed by gross and histologic measurements, compared to the nondiabetic controls. All drug treatments significantly improved wound closure with efficacy ratings as follows: 1% 2.24 > systemic 2.24 > 3% 2.24 with no effect on the severe hyperglycemia. In subsequent experiments, 1% CMC2.24 “normalized” wound-healing in the diabetics, whereas 1% curcumin was no more effective than 0.25% CMC2.24, and the latter remained 34% worse than normal. MMP-8 was increased 10-fold in the diabetic wounds and topically applied 1% (but not 0.25%) CMC2.24 significantly reduced this excessive collagenase-2; MMP-13/collagenase-3 did not show significant changes. Additional studies indicated efficacy of 1% CMC2.24 over more prolonged periods of time up to 30 days.
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Atwan, Yousif, Sheila Sprague, Gerard P. Slobogean, et al. "Does negative pressure wound therapy reduce the odds of infection and improve health-related quality of life in patients with open fractures?" Bone & Joint Open 3, no. 3 (2022): 189–95. http://dx.doi.org/10.1302/2633-1462.33.bjo-2021-0199.r1.
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Aims To evaluate the impact of negative pressure wound therapy (NPWT) on the odds of having deep infections and health-related quality of life (HRQoL) following open fractures. Methods Patients from the Fluid Lavage in Open Fracture Wounds (FLOW) trial with Gustilo-Anderson grade II or III open fractures within the lower limb were included in this secondary analysis. Using mixed effects logistic regression, we assessed the impact of NPWT on deep wound infection requiring surgical intervention within 12 months post-injury. Using multilevel model analyses, we evaluated the impact of NPWT on the Physical Component Summary (PCS) of the 12-Item Short-Form Health Survey (SF-12) at 12 months post-injury. Results After applying inverse probability treatment weighting to adjust for the influence of injury characteristics on type of dressing used, 1,322 participants were assessed. The odds of developing a deep infection requiring operative management within 12 months of initial surgery was 4.52-times higher in patients who received NPWT compared to those who received a standard wound dressing (95% confidence interval (CI) 1.84 to 11.12; p = 0.001). Overall, 1,040 participants were included in our HRQoL analysis, and those treated with NPWT had statistically significantly lower mean SF-12 PCS post-fracture (p < 0.001). These differences did not reach the minimally important difference for the SF-12 PCS. Conclusion Our analysis found that patients treated with NPWT had higher odds of developing a deep infection requiring operative management within 12 months post-fracture. Due to possible residual confounding with the worst cases being treated with NPWT, we are unable to determine if NPWT has a negative effect or is simply a marker of worse injuries or poor access to early soft-tissue coverage. Regardless, our results suggest that the use of this treatment requires further evaluation. Cite this article: Bone Jt Open 2022;3(3):189–195.
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Petrushin, A. L. "Traumatic hand amputations, the analysis of medical aid on different levels of rural healthcare." Kazan medical journal 94, no. 3 (2013): 327–34. http://dx.doi.org/10.17816/kmj2179.
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Aim. The analysis of diagnostic and management measures offered for patients with traumatic hand amputations at different levels of rural healthcare. Methods. The medical charts of 115 patients [including 98 (85.2%) in-patients] aged 14 to 67 years with complete and incomplete traumatic hand amputation treated since 1985 to 2010 were analysed. Results. 81 (70.4%) of patients were of working age, 18 (15.7%) - adolescents (up to 18 years of age). 65 (56.5%) of patients were blue-collar workers, 6 (5.2%) - white-collar workers, 19 (16.5%) - students, 12 (10.4%) - unemployed, 13 (11.3%) - retired. Occupational injuries were registered in 25 (21.7%) of patients, including 24 (36.9%) blue-collar workers and 1 (16.7%) white-collar worker. Traumatic hand amputations due to incised wounds were registered in 1 (0.9%) case, due to bites - 1 (0.9%) case, due to chopped wound - in 26 (22.6%) cases, due to lacerated wounds - in 35 (30.4%) cases, due to high-energy trauma - in 45 (39.1%) cases. No trauma mechanism was registered in patient’s medical charts for 7 (6.1%) cases. Traumatic hand amputations at wrist level were registered in 2 (1.7%) cases, at finger level - in 113 (98.7%) cases. The primary care was provided in regional paramedic stations and regional hospitals to 71 (61.7%) patients. High-energy traumas had the most unfavorable clinical course and were associated with worst prognosis. The chosen reconstructive surgery type depended on the mechanism of trauma, wound shape and size and the condition of surrounding tissues. The local reconstructive surgery was the most frequent choice. Complications were observed in 11.2% of cases (in 27.1% of high-energy trauma cases). Patients became constantly disabled in 4.3% of cases. Most of the medical errors were made at primary care level, including unjustified rejection of wound debridement and improper finger stump debridement. Conclusion. To optimize the medical aid for patients with traumatic hand amputations a continuous theoretical training of medical staff, providing emergency care, in quarterly seminars, is needed. Patients with traumatic hand amputations should be admitted directly to the hospital emergency room, bypassing the outpatient services.
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Al-Ebrahim, Khaled Ebrahim. "Management of Deep Sternal Wound Infection: Complete Sternal Osteomyelitis." Heart Surgery Forum 23, no. 3 (2020): E281—E284. http://dx.doi.org/10.1532/hsf.2805.
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Deep sternal wound infection (DSWI) after cardiac surgery is a challenging complication that affects the outcome of surgery. The worst type of DSWI is mediastinitis and sternal osteomyelitis, which dramatically increase morbidity, mortality, and cost of care. This case report describes successful treatment of sternal osteomyelitis after open heart surgery with combined negative pressure wound therapy and rectus abdominis flap. This combination of negative pressure wound therapy with rectus abdominis flap in treating sternal osteomyelitis after open cardiac surgery is not well studied.
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Nihir, Gupta, Nagar Anju, Meena Dharmraj, Meena Anshul, Singh Juhi, and Meena Radheyshyam. "Hollow Viscus Injuries in Abdominal Trauma: An Observational Clinical Study." International Journal of Toxicological and Pharmacological Research 13, no. 5 (2023): 213–19. https://doi.org/10.5281/zenodo.11212618.
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<strong>Background:</strong> In today’s highly developed civilised society, trauma is thought to be the main factor contributing to morbidity and mortality. <strong>Methods:</strong> In the current study, 50 cases of abdominal trauma (including blunt and penetrating wounds) were examined over a 12-month period in our institute. <strong>Results:</strong> Males between the ages of 21 and 30 were most frequently impacted. Injury from a car accident is the most frequent type. 93% of patients experienced abdominal pain, and 86% report tenderness. An upright abdomen plain x-ray was effective at spotting hollow viscus damage. An ultrasound examination clearly showed free fluid and solid organ damage. Small bowel was the viscera that was most frequently injured in this study, and it was treated with straightforward anastomosis, resection, and closure of perforations. There were postoperative issues such wound infection, wound dehiscence, respiratory issues, pelvic abscess, and faecal fistula. Most of the patients in this study stayed between 11 and 20 days, with a mean of 15 days. In this trial, mortality was 4%. <strong>Conclusions:</strong> Young boys are most frequently impacted by traffic accidents. The prognosis for penetrating abdominal trauma is made worse by factors such as small bowel injury, long time between injury and operation, presence of shock at admission, and female gender.
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Basani, Laxman, and Roja Aepala. "Leukocyte adhesion deficiency type I in a term neonate with late onset sepsis: a case report." International Journal of Contemporary Pediatrics 4, no. 1 (2016): 283. http://dx.doi.org/10.18203/2349-3291.ijcp20164621.
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Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency disorder of leukocyte function characterized by marked leucocytosis secondary to lack of leukocyte recruitment at the site of infection. LAD type I results from lack of expression of leukocyte cell surface β2 integrins (CD 11 and CD 18) that are essential for leukocyte adhesion to endothelial cells and chemotaxis. LAD I is characterized by delayed separation of the umbilical cord, recurrent life-threatening infections of oral and genital mucosa, skin, intestine and respiratory tract. There is impaired pus formation and delayed wound healing despite extreme neutrophilia. Children with severe form of LAD I (<1% expression of CD18) have the worst prognosis and succumb to infections by 2 years of age. Study reports a case of LAD I in a term neonate who presented with sepsis and the diagnosis was confirmed by flow cytometry. Around 400 cases of LAD I were diagnosed worldwide so far, with very few cases reported from India.
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Laine, Merit. "Rune Stones and Honourable Wounds: The Gothic Idea in Two Eighteenth-Century Swedish Medals." Diciottesimo Secolo 10 (June 10, 2025): 79–86. https://doi.org/10.36253/ds-15463.
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This paper discusses Northern European antiquity as perceived in Sweden during the Age of Liberty (1720-1771). Two unique medals presented to wounded participants in battles of the Pomeranian war are used as points of departure. The paper argues that the general perception (as opposed to specialist discourse) of Swedish antiquity in this period was based on conceptions of collective past identities, characteristics and practices, rather than specific individuals or events. This perception should be understood as a «networked idea», as defined by Shane Butler: «… what no single text has shown us, but which is seen all the same as residing in the tradition itself…». It is here designated «the Gothic idea», as the Gothic heritage was dominant among its sources. It was closely associated with the harsh natural conditions of the north, which were supposed to produce courageous and war-like inhabitants. Not least in martial and patriotic contexts, the Gothic idea was thus part of masculine self-understanding. It was also referenced in the literary and social culture of the time. However, it was difficult to represent and was thus disproportionally absent from visual and material culture. Rune stones were virtually the only type of object that was both widely familiar and associated with Swedish antiquity. Valued as literary sources, they were alien to eighteenth-century taste, but their depiction on the two medals discussed in this paper demonstrate that, on apparently rare occasions, rune stones were used to visually reference the Gothic idea. Their presence situated both givers and receivers of the medals within a living idea of northern antiquity that had been developed for several centuries (indeed, since antiquity) and, for better and worse, continues to evolve to this day. The development of an iconography that goes far beyond rune stones is part of this later story.
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Yetiser, Sertac, and Ugur Karapinar. "Hypoglossal-Facial Nerve Anastomosis: A Meta-Analytic Study." Annals of Otology, Rhinology & Laryngology 116, no. 7 (2007): 542–49. http://dx.doi.org/10.1177/000348940711600710.
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Objectives: A meta-analysis was conducted on the outcome of facial nerve function after hypoglossal-facial nerve anastomosis in humans. The roles of the timing of and the underlying cause for surgery, the type of the repair, and previous facial nerve function in the final result were analyzed. Methods: Articles were identified by means of a PubMed search using the key words “facial-hypoglossal anastomosis,” which yielded 109 articles. The data were pooled from existing literature written in English or French. Twenty-three articles were included in the study after we excluded those that were technical reports, those describing anastomosis to cranial nerves other than the hypoglossal, and those that were experimental animal studies. Articles that reported facial nerve function after surgery and timing of repair were included. Facial nerve function had to be reported according to the House-Brackmann scale. If there was more than 1 article by the same author(s), only the most recent article and those that did not overlap and that matched the above criteria were accepted. The main parameter of interest was the rate of functional recovery of the facial nerve after anastomosis. This parameter was compared among all groups with Pearson's X2 test in the SPSS program for Windows. Statistical significance was set at a p level of less than .05. Results: Analysis of the reports indicates that early repair, before 12 months, provides a better outcome. The severity of facial nerve paralysis does not have a negative effect on prognosis. Gunshot wounds and facial neuroma are the worst conditions for favorable facial nerve recovery after anastomosis. Transection of the hypoglossal nerve inevitably results in ipsilateral tongue paralysis and atrophy. Modification of the anastomosis technique seems to resolve this problem. Nevertheless, the effect of modified techniques on facial reanimation is still unclear, because the facial nerve function results were lacking in these reports. Conclusions: Hypoglossal-facial nerve anastomosis is an effective and reliable technique that gives consistent and satisfying results.
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Prirodov, A. V., A. E. Talypov, A. B. Klimov, et al. "Gunshot wounds of the head in peacetime, with the formation of a delayed carotid-cavernous fistula (case report)." Russian journal of neurosurgery 22, no. 3 (2020): 66–75. http://dx.doi.org/10.17650/1683-3295-2020-22-3-66-75.
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The objective of the article is to present the clinical observation of a gunshot wounds of the head in peacetime, with the formation of a delayed carotid-cavernous fistula.Clinical case. A patient aged 26 years received a penetrating parabasal single gunshot wound to the head. After transfer to the N.V. Sklifosovsky Research Institute of Emergency Medicine from a local hospital, intima dissection and occlusion of the left internal carotid artery (ICA) were diagnosed. Supraclinoid section of the left ICA, left anterior cerebral and middle cerebral arteries were filled from the right ICA through the anterior communicating artery. For prevention of suppurative-septic complications as well as decubitus of the left ICA and development of life-threatening hemorrhages, repeat surgery was performed. Acute subdural hematoma and brain detritus were removed. Using pterional approach, the chiasm and sellar region was accessed. Sequentially the ophthalmic, interpenducular, penducular cisterns, cisterna laminae terminalis and left carotid cistern were dissected. Sequentially the left ophthalmic nerve, left ICA, left choroid arteries were isolated. A metallic foreign object (bullet) located in the medial regions of the larger wing of the sphenoid bone and lateral wall of the cavernous sinus was found and removed. On day 14 after the second surgery, headache became worse, pulsing noise developed in the left part of the head, as well as moderate exophthalmos on the left. Left-hand type A (per the Barrow classification) carotid-cavernous anastomosis with retrograde inflow due to occlusion of the left ICA was diagnosed. Endovascular intervention was performed: separation of the carotid-cavernous anastomosis through retrograde occlusion of the supraclinoid segment of the left ICA with microcoils through contralateral ICA and anterior communicating artery. The patient was discharged at day 30 after hospitalization. Cerebral and meningeal symptoms regressed. Ptosis grade decreased, the left eye started to move.Conclusion. This abovementioned observation is of interest due to the rarity of such pathology and the possibilities of modern multidisciplinary centers for the diagnosis and treatment of such patients as of this date.
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Tsubakimoto, Yoshinori, Tatsuya Nakama, Daisuke Kamoi, Hiroshi Andoh, and Kazushi Urasawa. "Outcomes of Pedal Artery Angioplasty Are Independent of the Severity of Inframalleolar Disease: A Subanalysis of the Multicenter RENDEZVOUS Registry." Journal of Endovascular Therapy 27, no. 2 (2020): 186–93. http://dx.doi.org/10.1177/1526602820901838.
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Purpose: To examine the efficacy of pedal artery angioplasty (PAA) for chronic limb-threatening ischemia (CLTI) according to the severity of inframalleolar disease. Methods: In total, 257 consecutive CLTI patients (mean age 73.2 years; 175 men) with de novo infrapopliteal and inframalleolar artery disease were enrolled from the retrospective RENDEZVOUS registry. Inframalleolar artery disease was classified as moderate (Kawarada type 2, 144 patients) or severe (Kawarada type 3, 113 patients). PAA was performed in 140 patients: 66 (45.8%) with moderate disease and 74 (65.5%) with severe disease. The remaining 117 patients (78 with moderate disease and 39 with severe disease) underwent interventions that did not include PAA. The primary outcomes were the wound healing and limb salvage rates at 12 months after the initial treatment. The outcomes of the PAA and no-PAA groups were examined to determine any correlation between treatment efficacy and baseline disease severity. Results: The success rates of PAA among the patients with moderate and severe inframalleolar disease were 89.4% and 87.8%, respectively (p=0.683). The wound healing rate at 12 months was significantly higher in the PAA group than in the no-PAA group regardless of the severity of inframalleolar disease [moderate: 58.8% vs 40.0% (p=0.049); severe: 59.6% vs 33.2% (p=0.021), respectively]. The worst limb salvage rate (76.9%) was seen among patients in the no-PAA group with severe inframalleolar disease (no-PAA/moderate: 94.8%; PAA/moderate: 90.9%; and PAA/severe: 87.8%, p=0.028). Conclusion: PAA improves the wound healing rate of patients with CLTI regardless of the severity of inframalleolar disease. This treatment modality also might improve limb salvage rates in patients with severe inframalleolar disease affecting both the anterior and posterior pedal circulations.
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Fagher, Katarina, and Magnus Löndahl. "The combined impact of ankle–brachial index and transcutaneous oxygen pressure on mortality in patients with type 2 diabetes and foot ulcers." Acta Diabetologica 58, no. 10 (2021): 1359–65. http://dx.doi.org/10.1007/s00592-021-01731-9.
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Abstract Aims A diabetic foot ulcer (DFU) is associated with increased cardiovascular risk and mortality, independently of ulcer etiology (ischemic, neuro-ischemic or neuropathic). Ankle–brachial index (ABI) is the most commonly used test when diagnosing peripheral macrovascular disease and is a well-known marker for increased cardiovascular risk. Transcutaneous oxygen pressure (TcPO2) is considered to better evaluate microvascular function and has in previous studies shown correlations with both wound healing and survival. The aim of this study was to evaluate the combined impact of a low TcPO2 (<30 mmHg) and a pathological ABI (<0.9 or ≥1.4) on three-year mortality in patients with DFU. Methods Type 2 diabetes patients aged <90 years, with at least one DFU who underwent vascular assessment with ABI and TcPO2 were screened for participation. The primary endpoint was mortality after three years, assessed from the National Death Registry in Sweden. Results The study enrolled 235 participants with a median age of 76 years. Individuals with either an abnormally high or low ABI in combination with a low TcPO2 had the worst survival rates, with three-year mortality of 54%, compared to 42% in those with one abnormal variable (either ABI or TcPO2), and 21% in those with normal ABI and TcPO2. Conclusions Combining ABI and TcPO2 when risk stratifying DFU patients seems to provide additional predictive information, not only concerning ulcer healing and limb salvage, but also on survival.
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Pocecco, Elena, Inge Werner, Theresa Bischofer, and Gerhard Ruedl. "Sex/gender differences in injury risk, types of injuries, and potential risk factors of adult recreational mountain-bikers in Tyrol." Current Issues in Sport Science (CISS) 9, no. 4 (2024): 051. http://dx.doi.org/10.36950/2024.4ciss051.
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Introduction & Purpose In Austria, 99% of fatally injured (Pocecco et al., 2022) and 81% of accidented mountain-bikers (Woyke et al., 2024) are males. However, these evident sex/gender differences in prevalence do not allow any conclusions to be drawn either about the risk of injury or about potential risk factors between the sex/genders. Thus, the present study aimed to investigate possible sex/gender-specific differences in injury risk, types of injuries, and related potential risk factors in adult recreational mountain-bikers in Tyrol, Austria. Methods This retrospective survey was conducted in the surroundings of Innsbruck (Austria) in 2017-2019, involving randomly selected adult recreational mountain-bikers. A standardized questionnaire was used to collect data on injuries ever experienced during mountain-biking (MTB), including circumstances (e.g., skill level and risk-taking behaviour according to Ruedl et al. (2010), riding alone or in a group) related to the most severe injury. Proportions were compared by χ2 tests. Results In total, 1,439 mountain-bikers (37.8 ± 14.3 years, 33.4% females) were interviewed, 486 (33.8%) of them suffering one or more injuries requiring medical attention. Men showed a higher injury risk compared to women (37.2% vs. 26.9%, p < 0.001) and injured males reported a higher number of injuries during MTB compared to their female counterpart (2.4 ± 2.4 vs. 1.7 ± 1.4, p < 0.001). In general, concerning the most severe injury ever suffered during MTB, the most frequent injury types were fractures (28.4%), followed by open wounds (15.9%), contusions (14.5%), abrasions (12.0%), and ligament/muscle injuries (10.4%), showing sex/gender differences (p = 0.010). In particular, fractures were the most frequent injury type among male (32.7%), open wounds among female (20.3%) mountain-bikers. Moreover, men reported higher MTB skills (p < 0.001) and higher risk-taking behaviour (72.8% vs. 50.5%, p < 0.001) at the time of the worst accident compared to women. Additionally, males were more likely to be biking alone on the day of the accident compared to females (30.1% vs. 15.0%, p = 0.007), who tended to ride in groups. Discussion Comparably to alpine skiing and snowboarding (Ruedl et al., 2010), men were found to exhibit a higher skill level and engage in riskier behaviour more frequently than women. In alpine skiing and snowboarding, these two factors are associated with higher speeds (Ruedl et al., 2010), which could be therefore also the reason for the higher injury risk and frequency of fractures among the surveyed male mountain-bikers. In the present study, fractures were the most common self-reported injury type with 28%, which seems comparable to 24% of fractures in the study by Woyke et al. (2024). Conversely, biking in a group, which was more common among women, apparently did not lead to a higher risk of injury due to possible peer pressure. Conclusion Results of this study found sex/gender differences in injury risk, types of injury, and related potential risk factors in recreational adult mountain-bikers which should be considered in future preventive measures. In particular, relevant information campaigns should address especially males. Moreover, future research comparing injured and non-injured recreational mountain-bikers should be conducted to confirm or reject the hypothesized risk factors. References Pocecco, E., Wafa, H., Burtscher, J., Paal, P., Plattner, P., Posch, M., & Ruedl, G. (2022). Mortality in recreational mountain-biking in the Austrian Alps: A retrospective study over 16 years. International Journal of Environmental Research and Public Health, 19(19), Article 11965. https://doi.org/10.3390/ijerph191911965 Ruedl, G., Pocecco, E., Sommersacher, R., Gatterer, H., Kopp, M., Nachbauer, W., & Burtscher, M. (2010). Factors associated with self-reported risk-taking behaviour on ski slopes. British Journal of Sports Medicine, 44(3), 204-206. https://doi.org/10.1136/bjsm.2009.066779 Woyke, S., Hütter, A., Rugg, C., Tröger, W., Wallner, B., Ströhle, M., & Paal, P. (2024). Sex differences in mountain bike accidents in Austria from 2006 to 2018: A retrospective analysis. High Altitude Medicine & Biology, 25(1), 89-93. https://doi.org/10.1089/ham.2023.0086
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Alzahrani, Meshari A., Salman Bin Ofisan, Nasser I. Alshumaymiri, et al. "Effect of St. John’s Wort (Hypericum perforatum L.) on Male Sexual and Reproductive Health: A Narrative Review." Biomedicines 11, no. 10 (2023): 2800. http://dx.doi.org/10.3390/biomedicines11102800.
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Background: Hypericum species are widely acknowledged for their biological attributes, with notable attention being paid to Hypericum perforatum, commonly known as St. John’s wort (SJW) within the Hypericum section of the Hypericaceae family. This species is among the most thoroughly investigated herbal medicines, particularly in terms of its application in the management of mild to moderate depression. SJW is used to treat depression, menopausal symptoms, attention-deficit hyperactivity disorder (ADHD), somatic symptom disorder, obsessive–compulsive disorder, and skin conditions, such as wounds and muscle pain. However, the usefulness and effectiveness of SJW for male sexual and reproductive health (SRH) are not well known. Objective: To assess the current evidence in the literature on the effect of SJW on male SRH. Methods: This narrative review followed a predetermined protocol and used MEDLINE and PubMed to identify articles published in English on the effects of SJW on male SRH. The search used various keywords, such as “Hypericum Perforatum”, “St. John’s Wort”, and terms related to sexual and reproductive health issues. Articles published between the inception of the database and August 2023 were included. Results: We identified 12 articles published from 1999 to 2019, the majority of which were experimental and conducted on animals. These studies demonstrate variability in terms of design, sample size, type of SJW extract used, the dosage administered, and duration of treatment. Studies have indicated potential sexual dysfunction (SD) due to SJW, which includes reduced libido, delayed ejaculation, delayed orgasm, and erectile dysfunction. Additionally, reproductive toxicity has been suggested, as evidenced by spermicidal effects through the inhibition of sperm motility, abnormal spermatozoa, chromosomal aberrations, and DNA denaturation. Furthermore, some studies have reported potential adverse events during maternal exposure, inhibition of fertilization, and disruption of reproductive parameters. Conclusions: Our review suggests that the safety and efficacy of SJW in the treatment of human SRH remain unclear. Further comprehensive, well-designed studies with larger samples, longer exposure periods, and specific dosages are needed to clarify SJW's effects of SJW. Therefore, consultation with healthcare professionals before using herbal remedies or supplements is crucial.
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Zhou, Zheng, Gehou Zhang, Tieqi Li, et al. "LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma." Cancers 15, no. 3 (2023): 603. http://dx.doi.org/10.3390/cancers15030603.
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Background: Hypopharyngeal carcinoma is the worst type of head and neck squamous cell carcinoma. It is necessary to identify the key molecular targets related to the carcinogenesis and development of hypopharyngeal carcinoma. Methods: Differentially expressed lncRNAs in hypopharyngeal carcinoma were selected by microarray, and lncRNA-associated proteins were found by RIP assay. Colony formation, CCK-8, wound healing and Transwell assays were performed to detect the effects of lncRNA and its associated protein on cell proliferation and migration in vitro. Downstream pathways of lncRNA and its associated protein were detected by WB. Through a subcutaneous tumor model, the effects of lncRNA and its associated protein on cell proliferation were detected. The expressions of lncRNA and its associated protein in hypopharyngeal cancer tissues were detected by qRT-PCR and immunohistochemistry assays, respectively, and survival analyses were performed by Kaplan-Meier curve. Results: A total of 542 and 265 lncRNAs were upregulated and downregulated in microarrays, respectively. LncRNA NR120519 was upregulated and promoted cell proliferation and migration of hypopharyngeal carcinoma in vitro and cell proliferation in vivo. RIP and WB assays showed that KRT17 was associated with and blocked by NR120519.The silencing of KRT17 promoted cell proliferation and the migration of hypopharyngeal carcinoma in vitro and cell proliferation in vivo by activating the AKT/mTOR pathway and epithelial-mesenchymal transformation (EMT). Finally, the NR120519 high expression and KRT17 low expression groups showed shorter overall survival. Conclusion: NR120519 activated the AKT/mTOR pathway and EMT by blocking KRT17 to promote cell proliferation and the migration of hypopharyngeal carcinoma.
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Nurmalisa, Baiq Emy, and Supirno Supirno. "The Effect of Diabetic Foot Exercises on Ankle Brachial Index Values and the Degree of Diabetic Foot Risk in Diabetes Melitus Patients." Lentora Nursing Journal 3, no. 1 (2022): 44–50. http://dx.doi.org/10.33860/lnj.v3i1.2075.
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Background: The prevalence of Diabetic Foot Ulcers (DFU) in diabetics is 4-10% where this condition more often affects the elderly. DFU is a serious marker of a disease that if optimal prevention is not carried out from the start, the wound deteriorates rapidly, and the worst is amputation. Diabetic foot exercises are used as leg exercises and are beneficial in reducing pain, reducing nerve damage, controlling blood sugar and increasing blood circulation in the feet. The purpose of this study was to analyze the effect of diabetic foot exercise on the degree of risk of diabetic foot ulcers and the Ankle brachial index value in Diabetes Mellitus patients in the Work Area of the Mamboro Health Center. Methods: This type of research is quasi-experimental with a one group pretest posttest design. The sample is 16 people. The instruments used were a monofilament test, sphygmomanometer, stethoscope, and an instrument for assessing the risk of diabetic foot. Data analysis used is paired t test and Wilcoxon test. Results The results showed that diabetic foot exercise had an effect on changes in the value of blood circulation (ABI) with a p value (0.000) and a score of degrees of risk of diabetic foot with a p value (0.001). Conclusion of this study is that diabetic foot exercise has a statistical effect on both the ABI value and the diabetic foot degree score. Suggestions from this study are that nurses more often conduct DM foot exercise education in an effort to prevent DFU
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Gontjes, Kyle, Kristen Gibson, Bonnie Lansing, Marco Cassone, and Lona Mody. "Simplifying Surveillance Sampling: Can Environmental Surveillance Replace Perianal Screening?" Infection Control & Hospital Epidemiology 41, S1 (2020): s15—s16. http://dx.doi.org/10.1017/ice.2020.488.
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Background: Although active surveillance for multidrug-resistant organism (MDRO) colonization permits timely intervention, obtaining cultures can be time-consuming, costly, and uncomfortable for patients. We evaluated clinical differences between patients with and without attainable perianal cultures, and we sought to determine whether environmental surveillance could replace perianal screening. Methods: We collected active surveillance cultures from patient hands, nares, groin, and perianal area upon enrollment, at day 14, and monthly thereafter in 6 Michigan nursing homes. Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and resistant gram-negative bacilli (RGNB) were identified using standard methods. Patient characteristics were collected by trained research professionals. This substudy focused on visits during which all body sites were sampled. To determine the contribution of perianal screening to MDRO detection, site of colonization was categorized into 2 groups: perianal and non-perianal. We evaluated the utility of multisite surveillance (eg, type 1 and type 2 error) using nonperianal sites and environment surveillance. To evaluate characteristics associated with the acquisition of perianal cultures (eg, selection bias), we compared clinical characteristics, overall patient colonization, and room environment contamination of patients in whom all body sites were sampled during a study visit (533 patients; 1,026 visits) to patients with all body sites except the perianal culture sampled during a study visit (108 patients; 168 visits). Results: Of 651 patients, 533 met the inclusion criteria; average age was 74.5 years, 42.6% were male, and 60.8% were white. Of 1,026 eligible visits, 620 visits detected MDRO colonized patients; 155 MRSA, 363 VRE, and 386 RGNB (Table 1). If perianal cultures were not collected, nonperianal surveillance misses 7.7%, 41.3%, and 45.1% of MRSA, VRE, and RGNB colonized visits, respectively. The addition of environmental surveillance to non-perianal screening detected 95.5%, 82.9%, and 67.9% of MRSA, VRE, and RGNB colonized visits, respectively. The specificity of environmental screening was 85.3%, 72.7%, and 73.4% for MRSA, VRE, and RGNB, respectively. Patients without attainable perianal cultures had significantly more comorbidities, worse functional status, shorter length of stay, and higher baseline presence of wounds than patients with attainable perianal cultures; introducing potential selection bias to surveillance efforts (Table 2). No significant differences in overall patient colonization and room contamination were noted between patients with and without attainable perianal cultures. Conclusion: Perianal screening is important for the detection of VRE and RGNB colonization. Infection prevention must be cognizant of the tradeoff between reducing type 2 error and the selection bias that occurs with required attainment of perianal cultures. In the absence of perianal cultures, environmental surveillance improves MDRO detection while introducing type 1 error.Funding: NoneDisclosures: None
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Ishtukov, R. R., M. A. Nartailakov, V. S. Panteleev, and V. V. Rezyapov. "ESTIMATION OF EFFICIENCY OF COLLAGEN AND BIOLOGICAL GLUE AT DUODENAL FISTULA IN EXPERIMENT." Creative surgery and oncology 8, no. 1 (2018): 69–75. http://dx.doi.org/10.24060/2076-3093-2018-8-1-69-75.
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Introduction. One of the worst complication of different surgical diseases of abdominal cavity organs and of performed, on that regard, operational interventions, are intestinal festulas including without limitation deodenum fistulas. Longterm experience of surgical treatment of patients with unformed duodenal and high enteric fistulas show that it is feasible to have a clear surgical tactics with account of location level and type of fistulas, their quantity, volume of sarcous reduction, peritonitis and multi-organ failure syndrome. In this regard, the objective of this research is to find optimal surgical tactics and to determine the most effective method of treating duodenum fistulas of various causation.Materials and methods. Experimental work was carried out under conditions of experimentally formed intestinal fistula in rabbits of “Shinshilla” breed. After formation of fistula the animals were divided into 3 groups based on the method of removing artificially installed duodenal fistula: sealing through Albert — Schmieden — Lembert suture without fastening of suture line; sealing through fastening of intestinal suture with biological surgical glue; sealing through fastening with swine dermal collagen. Mechanical constancy of the sutures was measured with pneumocompression of sealed intestinal tract areas as well as with morphological study of surgical wound edges.Results. The results of histological study show that experiments with application of bio-implant demonstrated less vascular congestion and interstitial swelling. Phologistic infiltration also responded more efficiently both quantitatively (manifestation rate) and qualitatively (quick change of cell elements) in the group that used bio-implant.Conclusion. Results of morphological studies and pneumocompression data under modelling of duodenal fistulas in experimental animals show that application of bio-implant helps to earlier restore microcirculatory abnormality.
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McAndrew, Morgan, Hannah Havran, Luca Di Martino, Mahmoud Ghannoum, Theresa Pizarro, and Carlo De Salvo. "NOD2 PROMOTES HOST DEFENSE AND RECOVERY INDUCING MACROPHAGE-MEDIATED INNATE LYMPHOID CELLS TYPE 3 ACTIVATION FOLLOWING FUNGAL INFECTION IN EXPERIMENTAL COLITIS." Inflammatory Bowel Diseases 28, Supplement_1 (2022): S59. http://dx.doi.org/10.1093/ibd/izac015.093.
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Abstract Recent studies have documented the complexity of the intestinal fungal community (‘mycobiome’) in mice, and clinical and experimental observations have shown that the mycobiome influences both gut health and disease, e.g., inflammatory bowel disease (IBD). In fact, prior studies have shown that Crohn’s disease (CD) patients, compared to healthy controls, harbor higher levels of intestinal Candida tropicalis (Ct), which is the major fungal species detected in the colons of colitic mice after DSS challenge. More recently, Debaryomyces hansenii (also known as Candida famata) has been found in intestinal wounds of mice and inflamed mucosal tissues of CD patients. Moreover, proteins encoded by genes within IBD susceptibility loci, such as the pattern recognition receptor (PRR), NOD2, are known not only to recognize bacterial components, but also a fungal cell wall element, chitin. In fact, the role of PRRs in regulating immunity against intestinal fungi, and how fungi influence IBD remains poorly defined. We challenged DSS colitic WT and Nod2-/- mice with Ct 2 days before DSS administration and subsequently on day (d)0, 3 and 6. Our data confirms previous studies that Ct challenge does not exacerbate colitis in DSS-treated C57BL/6 wildtype (WT) mice, however, Ct-infected Nod2-/- mice possess a higher fungal burden and exhibit worse colitis symptoms, such as weight loss, decreased stool consistency, and presence of blood in stools, vs. Ct-infected WT mice, indicating an essential and protective role for NOD2 during colitis recovery after Ct challenge. Our results also show that Ct-infected Nod2-/- mice display a marked reduction in colonic Il22 and Il17, which are cytokines previously reported to be important in maintaining epithelial barrier integrity during DSS colitis, These data were confirmed in colons of Ct infected DSS challenged, ileitis-prone SAMP1/YitFc (SAMP) mice that were deficient in NOD2. Moreover, Our in vitro data show, a decrease in Il1b and Il23 in bone marrow-derived macrophages from SAMP Nod2-/- mice compared to WT after 2h of exposure to chitin. IL-17+ innate lymphoid cells (ILCs) are also known to control fungal burden during opportunistic fungal infections, and interestingly, our findings indicate that Ct infection of Nod2-/- vs. WT mice results in a decreased frequency of mesenteric lymph node–derived type 3 ILCs (ILC3s), suggesting that delay in fungal clearance and recovery in Nod2-/- mice may be due to the inability to mount protective type 3 immune responses. Taken together, the data so far collected suggests that NOD2 is essential to maintain gut mycobiome homeostasis and drives protective innate immune responses, via a macrophage-mediated ILC3 recruitment and IL-17 mechanism, by preventing the overgrowth of opportunistic fungi that may contribute to chronic intestinal inflammation, such as that observed in CD.
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O’Donovan, Siobhan, Neil E. I. Langlois, and Roger W. Byard. "“Defense” type wounds in suicide." Forensic Science, Medicine and Pathology 14, no. 3 (2018): 402–5. http://dx.doi.org/10.1007/s12024-018-9957-y.
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Buckland, Edward. "The offshore trust industry’s biggest enemy… itself??" Trusts & Trustees 25, no. 7 (2019): 747–52. http://dx.doi.org/10.1093/tandt/ttz061.
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Abstract The offshore trust industry is undoubtedly under sustained and concerted attacks. However, is the industry’s real worst enemy itself? This article considers how many of the wounds suffered have actually been self-inflicted, and calls upon the offshore trust industry to take a long hard look in the mirror before automatically blaming others for its own faults.
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Can, Bilgen, Yusuf Furkan Kırış, Hatip Dağ, Yunus Çağrı Güzel, and Ahmet Dolapoğlu. "Sternal wound types after median sternotomy and reconstruction using dead space-based approach." Turkish Journal of Thoracic and Cardiovascular Surgery 32, no. 3 (2024): 261–70. http://dx.doi.org/10.5606/tgkdc.dergisi.2024.26053.
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Background: This study aims to classify wound complications after median sternotomy and provide an up-to-date reconstructive algorithm for multidisciplinary use. Methods: A total of 15 patients (9 males, 6 females; mean age: 68±5 years; range, 60 to 75 years) who underwent sternal reconstruction for wound complications following median sternotomy between August 2020 and October 2023 were retrospectively analyzed. Wound complications requiring reconstruction were classified into three categories based on the extent of the dead space caused by sternal debridement. Type 1, 2, and 3 wounds presented with only skin defects and an intact sternum, with partial and total sternectomy, respectively. The time to consultation for plastic surgery and the duration of hospitalization were compared. Results: Among the wounds, type 2 wounds were the most common type seen in 11 patients. Two patients each had type 1 and type 3 wounds. A superior epigastric artery perforator skin flap was used for type 1 wounds. Bilateral pectoral and split pectoral turnover muscle flaps from the side where the internal mammary artery was intact were used for type 2 wounds. A rectus abdominis muscle flap was used for type 3 wounds. Early consultation from plastic surgery reduced the length of hospital stay. Conclusion: For type 1 wounds, skin flaps ensured sufficient coverage as they involved skin and subcutaneous fat, matching the defect. However, sternal excision required muscle flaps to fill the dead space, in which the vital organs were exposed.
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Swaim, Steven F., Dana M. Vaughn, Steven A. Kincaid, et al. "Effects of locally injected medications on healing of pad wounds in dogs." American Journal of Veterinary Research 57, no. 3 (1996): 394–99. http://dx.doi.org/10.2460/ajvr.1996.57.03.394.
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Abstract Objective To ascertain the effects of locally injected immunostimulant and tripeptide-copper complex (TCC) on improving healing of pad wounds. Design Wounds in pads of large dogs were injected with either medication or physiologic saline solution (controls). Healing was evaluated. Animals 12 mature English Pointers. Procedure Full-thickness 6 × 8-mm wounds in metatarsal and third and fourth digital pads were injected with immunostimulant or TCC at 0, 3, and 6 days after wounding. Wounds on control dogs were injected with physiologic saline solution. Using planimetric measurements at 0, 3, 6, 14, and 21 days, rates of healing were evaluated. Biopsy of the digital pad wounds at 3, 6, and 14 days was used to evaluate collagen content by hydroxyproline analysis. Biopsy specimens were also evaluated for type-I and type-III collagen, using Sirius red differential staining. Results Effect on healing rate and hydroxyproline content was best during the first week for immunostimulant. Immunostimulant- and TCC-injected wounds had more type-I collagen than did controls at 6 days; TCC-injected wounds had the most type-I collagen. At 14 days, the amount of type-I collagen in TCC-injected wounds was significantly greater than that in other wounds. Conclusions Tested medications had positive effects on healing of pad wounds. Clinical Relevance Intralesional injection of medications helps ensure their presence for enhancement of wound healing. The benefit could be lost with topical use in a bandage if the bandage is lost or becomes wet.(Am J Vet Res 1996;57:394-399)
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Yousefi, Omid, Pouria Azami, Roham Borazjani, Amin Niakan, Mahnaz Yadollahi, and Hosseinali Khalili. "Civilian penetrating traumatic brain injury: A 5-year single-center experience." Surgical Neurology International 14 (January 27, 2023): 28. http://dx.doi.org/10.25259/sni_1160_2022.
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Background: The aim of this study was to report the demographics and clinical features of patients with penetrating traumatic brain injury (PTBI) during the past 5 years in Rajaee Hospital, a tertiary referral trauma center in Shiraz, southern Iran. Methods: We conducted a 5-year retrospective evaluation of all patients diagnosed with PTBI who were referred to Rajaee Hospital. We retrieved the following items from the hospital’s database and PACS system: patients’ demographics, on-admission Glasgow Coma Scale (GCS), presence of trauma to other organs, duration of the hospital and ICU stay, the neurosurgical interventions, any necessity of tracheostomy, duration of ventilator dependency, the entrance point of the trauma in the skull, type of assault, length of trajectory in the brain parenchyma, the number of remaining objects in the brain, the occurrence of any hemorrhagic phenomenon, the cross of the bullet from the midline or coronal suture, and the presence of the pneumocephalus. Results: A total of 59 patients with a mean age of 28.75 ± 9.40 had PTBI over the 5 years. The mortality rate was 8.5%. Stab wounds, shotguns, gunshots, and airguns were the cause of injury in 33 (56%), 14 (23.7%), 10 (17%), and 2 (3.4%) patients, respectively. The median initial GCS of patients was 15 (3–15). Intracranial hemorrhage was observed in 33 cases, subdural hematoma in 18 cases, intraventricular hemorrhage in eight cases, and subarachnoid hemorrhage in four cases. The mean duration of hospitalization was 10.05 ± 10.75 (ranging from 1 to 62 days). Furthermore, 43 patients experienced ICU admission with mean days of 6.5 ± 5.62 (1–23). The temporal and frontal regions were the most common entrance points, in 23 and 19 patients, respectively. Conclusion: The incidence of PTBI is relatively low in our center, possibly due to the prohibition of possession or using warm weapons in Iran. Further, multicenter studies with larger sample sizes are needed to determine prognostic factors associated with worse clinical outcomes after PTBI.
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Jones, Roger H. "Stance is worst type of spin." BMJ 335, no. 7618 (2007): 465.1–465. http://dx.doi.org/10.1136/bmj.39317.635579.be.
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Wang, Di, and Jan Hoffmann. "Type-guided worst-case input generation." Proceedings of the ACM on Programming Languages 3, POPL (2019): 1–30. http://dx.doi.org/10.1145/3290326.
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Rohmayanti and Estrin Handayani. "Modern wound care application in diabetic wound management." International Journal of Research in Medical Sciences 5, no. 2 (2017): 702. http://dx.doi.org/10.18203/2320-6012.ijrms20170178.
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Diabetes mellitus is a group of metabolic disease which facilitates diabetic wound foot. To prevent long diabetic wound complication and worse condition it is needed wound care for diabetic patient. Modern bandage has been used for recent wound care technique. The principles of modern wound care product are maintaining and watching over the humid environment of the wound to facilitate the wound healing process, maintaining liquid tissue deprivation and cell decease. This research was aimed to find out how modern wound bandage is applied to the diabetic patient and to find out the influence in healing wound phase. This research is qualitative research using phenomenology approach, 4 wound diabetic patients who were hospitalized for 2 weeks using modern wound care method in Magelang regency were participated. The participants were elected using purposive sampling method. Observation and interview were used to obtain data, data was analyzed using explanation building method. The results of this research have 4 topics which are wound examination, type of modern bandage, the way of wound care, and the influence toward the wound. Bates-Jensen Wound was used for the wound examination, the type of bandage used were hydrogel and wound ointment, TIME management approach was used in wound care, and the wound care influences the decreasing of wound size, wound proliferation and granulation. Modern bandage application of diabetic wound influences the decreasing of wound size, wound proliferation and granulation. Paramedic is suggested to use modern wound care method in diabetic wound management.
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Alamgir, Mithun, Rukhsana Parvin, and Md Aminul Haque Khan. "Tragedy in Savar: Management of Victims in Enam Medical College Hospital." Journal of Enam Medical College 4, no. 1 (2014): 31–35. http://dx.doi.org/10.3329/jemc.v4i1.18066.
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Background: Rana Plaza collapse is the worst and deadliest man-made industrial disaster in the history of garment sector in the world. Around 1200 people died and thousands more were injured. Most of the victims of the disaster were treated in Enam Medical College Hospital (EMCH). We conducted this study to give an overview on the disaster victims and services provided by EMCH. Objective: The study was done to observe the length of time between accident and admission in EMCH, length of time between admission and discharge, to observe the numbers, types and sites of injuries to the victims, medical measures given to the victims and finally to observe the status of the victims at the time of discharge. Materials and Methods: This descriptive type of observational study was carried out among the victims of Rana Plaza tragedy during the period of May to October 2013. All admitted patients in EMCH were included in the study. Purposive nonprobability sampling technique was applied in this research work. Data were collected from the hospital record. After collection, data were manually compiled, edited and analyzed. Results: Among 621 victims treated in different wards, 276 (44.45%) were admitted to the hospital on the day of accident. Among the admitted patients, 255 (41.06%) stayed in the hospital for 1--3 days,133 (21.42%) for 4--7 days and 88 (14.17%) for more than 10 days. Fracture and dislocation were present in 32.70% patients, lacerated injury in 18.20%, abrasion in 15.78%, bruise in 13.53%, incised wound in 15.45% and punctured wound in 4.34% patients. Single injury was present in 56.68% and rest had multiple injuries. Lower limbs were the most (33.01%) affected part of the body followed by head and neck (22.06%), upper limbs (18.52%), thorax (17.55%) and abdomen (8.86%). Two hundred seventy two patients (43.80%) were improved after treatment and 56 (9.02%) were fully cured; 23.83% of the victims were referred to higher medical centers for special measures. Conclusion: The collapse of Rana Plaza has fueled a greater call for reform and safety in garment industry. At the same time, all health care centers should adopt a broad-based approach to disaster-preparedness by providing a framework to ensure a well-coordinated response to mass casualty event. DOI: http://dx.doi.org/10.3329/jemc.v4i1.18066 J Enam Med Col 2014; 4(1): 31-35
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Bain, Michael A., George J. Koullias, Keith Morse, Santina Wendling, and Michael L. Sabolinski. "Type I collagen matrix plus polyhexamethylene biguanide antimicrobial for the treatment of cutaneous wounds." Journal of Comparative Effectiveness Research 9, no. 10 (2020): 691–703. http://dx.doi.org/10.2217/cer-2020-0058.
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Aim: Determine the effectiveness of purified native type I collagen matrix plus polyhexamethylene biguanide antimicrobial (PCMP) on cutaneous wounds. Materials & methods: A prospective cohort study of 307 patients (67 venous leg ulcers, 62 diabetic foot ulcers, 45 pressure ulcers, 54 post-surgical wounds and 79 other wounds) was conducted. Results: Cox wound closure for PCMP was 73% at week 32. The median time to wound closure was 17 weeks (Kaplan–Meier). The incidence of PCMP-treated wounds showing >60% reductions in areas, depths and volumes were 81, 71 and 85%, respectively. Conclusion: PCMP demonstrated clinically meaningful benefits to patients with various types of cutaneous wounds. Clinical Trial registration number: NCT03286452.
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Steenvoorde, Pascal, Cathrien E. Jacobi, Louk Van Doorn, and Jacques Oskam. "Maggot Debridement Therapy of Infected Ulcers: Patient and Wound Factors Influencing Outcome – A Study on 101 Patients with 117 Wounds." Annals of The Royal College of Surgeons of England 89, no. 6 (2007): 596–602. http://dx.doi.org/10.1308/003588407x205404.
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INTRODUCTION It has been known for centuries that maggots are potent debriding agents capable of removing necrotic tissue and slough. In January 2004, the US Food and Drug Administration decided to regulate maggot debridement therapy (MDT). As it is still not clear which wounds are likely or unlikely to benefit from MDT, we performed a prospective study to gain more insight in patient and wound characteristics influencing outcome. PATIENTS AND METHODS In the period between August 2002 and December 2005, patients with infected wounds with signs of gangrenous or necrotic tissue who seemed suited for MDT were enrolled in the present study. In total, 101 patients with 117 ulcers were treated. Most wounds were worst-case scenarios, in which maggot therapy was a treatment of last resort. RESULTS In total, 72 patients (71%) were classified as ASA III or IV. In total, 78 of 116 wounds (67%) had a successful outcome. These wounds healed completely (n = 60), healed almost completely (n = 12) or were clean at least (n = 6) at last follow-up. These results seem to be in line with those in the literature. All wounds with a traumatic origin (n = 24) healed completely. All wounds with septic arthritis (n = 13), however, failed to heal and led in half of these cases to a major amputation. According to a multivariate analysis, chronic limb ischaemia (odds ratio [OR], 7.5), the depth of the wound (OR, 14.0), and older age (≥ 60 years; OR, 7.3) negatively influenced outcome. Outcome was not influenced by gender, obesity, diabetes mellitus, smoking, ASAclassification, location of the wound, wound size or wound duration. CONCLUSIONS Some patient characteristics (i.e. gender, obesity, smoking behaviour, presence of diabetes mellitus and ASA-classification at presentation) and some wound characteristics (i.e. location of the wound, wound duration and size) do not seem to contra-indicate eligibility for MDT. However, older patients and patients with chronic limb ischaemia or deep wounds are less likely to benefit from MDT. Septic arthritis does not seem to be a good indication for MDT.
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Grégoire, Yany, Thomas M. Tripp, and Renaud Legoux. "When Your Best Customers Become Your Worst Enemies: Does Time Really Heal all Wounds?" GfK Marketing Intelligence Review 3, no. 1 (2011): 26–35. http://dx.doi.org/10.2478/gfkmir-2014-0053.
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Abstract Customer revenge and avoidance in the context of online complaints by the public are hot topics. This article helps managers to understand the phenomenon and to prevent damage. Do online complainers hold a grudge-in terms of revenge and avoidance desires-over time? Results show that time affects the two desires differently: although revenge decreases over time, avoidance increases over time, indicating that customers hold a grudge. Then, we examine the moderation effect of a strong relationship on how customers hold this grudge. Indeed firms’ best customers have the longest unfavorable reactions. This is called the love-becomes-hate effect. Specifically, over time the revenge of strong-relationship customers decreases more slowly, and their avoidance increases more rapidly, than for weak-relationship customers. Further, we explore a solution to attenuate this damaging effect: the firm offering an apology and compensation after the online complaint. Overall, strong-relationship customers are more amenable to any level of recovery attempt.
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Zhirkova, E. A., A. V. Sachkov, T. G. Spiridonova, et al. "Burns and donor site treatment using allogeneic type I collagen." Transplantologiya. The Russian Journal of Transplantation 14, no. 4 (2022): 432–43. http://dx.doi.org/10.23873/2074-0506-2022-14-4-432-443.
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Introduction. The search for methods to reduce the time of treatment of burns and wounds of the donor sites currently remains relevant.Aim. Objective of this retrospective study was to evaluate the effectiveness of local treatment of II–IIIA degree burns and donor site wounds with dressings based on allogeneic type I collagen.Material and methods. The study included 434 patients hospitalized in 2018–2021. Collagen dressings were used in 280 patients (234 with II–IIIA degree burns and 46 with donor site wounds); 154 patients of the comparison group received traditional treatment in accordance with the standards of care for burns. Patients did not differ statistically significantly in age and the area of burns (general, superficial, deep). Lyophilized, sterile dressings based on type I collagen (RC No. FSR 2009/06370 December 8, 2014) were manufactured in accordance with TU No. 9393-002-01967081-2008 by the Department for Tissue Preservation and Graft Manufacturing of our Institute. We compared the timing of wound epithelialization when using collagen dressings versus the conventional treatment, and the pain intensity in the donor sites as assessed by the visual analogue scale for pain.Results. The terms of complete epithelialization of II–IIIA degree burn wounds made 10 (7;12) days when collagenbased dressings were used, and 18 (14;20) days without collagen, the difference being statistically significant (p<0.001). Epithelialization of the donor site wounds took 9 (8;10) days with using collagen dressings, and 11 (10;12) days with conventional treatment (p<0.001). The visual analogue scale assessed pain intensity in the donor site wounds after collagen application was statistically significantly lower on days 1, 4, and 7 than in patients on conventional treatment (p<0.001, p<0.001, p=0.003, respectively).Conclusion. The use of dressings based on type I allogeneic collagen for the treatment of superficial burns and the donor sites reduces the time of re-epithelialization, decreases the pain intensity in the donor site wounds, which proves the greater efficacy of this treatment method.
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Yordanova, Snejana. "Industrial Design of Type-1 and Interval Type-2 Fuzzy Logic Control." Jordan Journal of Electrical Engineering 11, no. 1 (2025): 1. http://dx.doi.org/10.5455/jjee.204-1720610452.
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This paper focuses on the design of type-1 and interval type-2 (IT2) PID fuzzy logic controllers (FLC) for ensuring - by a programmable logic controller (PLC) - a high-performance real-time liquid level control in a carbonization column (CCl) for soda production. Firstly, Takagi-Sugeno-Kang models - derived via genetic algorithms parameter optimizations, experimental data and simulations for the basic and the worst CCl loads - are studied at different operation points, and the worst Ziegler-Nichols (ZN) model is assessed. Next, two-input fuzzy units are designed - assuming various membership functions (MF) and uncertainties - and the greatest linearization gain is computed. Based on it and the ZN worst plant model, the parameters of the FLC input pre-processing differentiator and the PI post-processing are empirically tuned. Finally, a PLC oriented analytical description of the IT2 MF, fuzzy rules and type-reduction is suggested. The designed FLC systems are studied via simulation to determine the factors that have the greatest impact on the system performance improvement. The obtained results unveil that the tuned FLC outperforms the tuned linear PI. Better system performance is achieved by a small number of MF with large support ensuring economical PLC presentation.
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Guo, Mingyu. "Worst-Case VCG Redistribution Mechanism Design Based on the Lottery Ticket Hypothesis." Proceedings of the AAAI Conference on Artificial Intelligence 38, no. 9 (2024): 9740–48. http://dx.doi.org/10.1609/aaai.v38i9.28832.
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We study worst-case VCG redistribution mechanism design for the public project problem. The mechanism design task comes down to designing a payment function that maximizes the worst-case allocative efficiency ratio. We use a multilayer perceptron (MLP) with ReLU activation to model the payment function and use mixed integer programming (MIP) to solve for the worst-case type profiles that maximally violate the mechanism design constraints. We collect these worst-case type profiles and use them as training samples to train toward better worst-case mechanisms. In practice, we require a tiny neural network structure for the above approach to scale. The Lottery Ticket Hypothesis states that a large network is likely to contain a "winning ticket" -- a much smaller subnetwork that "won the initialization lottery", which makes its training particularly effective. Motivated by this hypothesis, we train a large network and prune it into a tiny subnetwork. We run MIP-based worst-case training on the drawn subnetwork and evaluate the resulting mechanism's worst-case performance. If the subnetwork does not achieve good worst-case performance, then we record the type profiles that cause the current draw to be bad. To draw again, we restore the large network to its initial weights and prune using recorded type profiles from earlier draws, therefore avoiding drawing the same ticket twice. We expect to eventually encounter a tiny subnetwork that leads to effective training for our worst-case mechanism design task. Lastly, a by-product of multiple ticket draws is an ensemble of mechanisms with different worst cases, which improves the worst-case performance further. Using our approach, we find previously unknown optimal mechanisms for up to 5 agents. Our results confirm the tightness of existing theoretical upper bounds. For up to 20 agents, we derive significantly improved worst-case mechanisms, surpassing a long list of existing manual results.
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Oliveira, Romulo Silva de, Mayara Marques Pereira Fernandes, Millena do Nascimento Mesquita, et al. "Therapeutic laser with or without andiroba oil in treating cutaneous wounds by second intention in Wistar rats." Acta Veterinaria Brasilica 15, no. 4 (2021): 316–22. http://dx.doi.org/10.21708/avb.2021.15.4.10027.
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This study’s objective was to evaluate the efficacy of treating cutaneous wounds in Wistar rats using a therapeutic laser alone or in combination with topical application of andiroba oil. Twenty-four Wistar rats were distributed into three groups (T4, T7, and T14) of eight animals. To prepare the wounds, a total of four skin fragments per animal were removed using an 8-mm cutaneous biopsy punch. Each animal was inflicted with four surgical wounds, and each wound was subjected to one treatment. The treatments were as follows: saline solution (control, Cn); laser therapy (L), using a 660-nm laser wavelength and 10-J/cm² energy density; fresh andiroba oil (An); laser therapy followed by topical andiroba oil administration (LAn). All treatments in all animals were conducted for 4- (T4), 7- (T7), and 14- (T14) day periods. Edema and purulent secretion were observed in three animals in the An group, and the appearance of an exuberant crust was also observed in one animal from the same group. The LAn group presented the worst wound healing rate and contraction velocity (p < 0.05). Microscopically, there was no difference between groups regarding the presence of inflammation, necrosis, formation of granulation tissue, fibroplasia, and the presence of types 1 and 3 collagen at different treatment times. It was concluded that laser treatment of cutaneous wounds in conjunction with andiroba oil application did not present benefits in reference to the 0.9% NaCl.
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Oliveira, Romulo Silva de, Mayara Marques Pereira Fernandes, Millena do Nascimento Mesquita, et al. "Therapeutic laser with or without andiroba oil in treating cutaneous wounds by second intention in Wistar rats." Acta Veterinaria Brasilica 15, no. 4 (2021): 316–22. http://dx.doi.org/10.21708/avb.2021.15.4.10027.
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This study’s objective was to evaluate the efficacy of treating cutaneous wounds in Wistar rats using a therapeutic laser alone or in combination with topical application of andiroba oil. Twenty-four Wistar rats were distributed into three groups (T4, T7, and T14) of eight animals. To prepare the wounds, a total of four skin fragments per animal were removed using an 8-mm cutaneous biopsy punch. Each animal was inflicted with four surgical wounds, and each wound was subjected to one treatment. The treatments were as follows: saline solution (control, Cn); laser therapy (L), using a 660-nm laser wavelength and 10-J/cm² energy density; fresh andiroba oil (An); laser therapy followed by topical andiroba oil administration (LAn). All treatments in all animals were conducted for 4- (T4), 7- (T7), and 14- (T14) day periods. Edema and purulent secretion were observed in three animals in the An group, and the appearance of an exuberant crust was also observed in one animal from the same group. The LAn group presented the worst wound healing rate and contraction velocity (p < 0.05). Microscopically, there was no difference between groups regarding the presence of inflammation, necrosis, formation of granulation tissue, fibroplasia, and the presence of types 1 and 3 collagen at different treatment times. It was concluded that laser treatment of cutaneous wounds in conjunction with andiroba oil application did not present benefits in reference to the 0.9% NaCl.
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Scotland, Tom. "Henry Gray and John Fraser: Scottish surgeons of the Great War." Res Medica 24, no. 1 (2017): 96–102. http://dx.doi.org/10.2218/resmedica.v24i1.2508.
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Between 1914 and 1918, the British Expeditionary Force fighting in France and Flanders sustained 2.7 million battle casualties. Just over one quarter (26.1%) were never seen by the medical services. These were men who had been killed (14.2%), were missing (5.4%), or were prisoners of war (6.5%). Most of those who were missing had been killed and their bodies never recovered. Just under three-quarters of the wounded (73.9% or 1 988 969) were seen and treated by the medical services and 151 356 died.[i] The worst single day in British military history was Saturday 1 July 1916, the first day of the Battle of the Somme, when there were 57 470 casualties, of whom 20 000 were killed or died from their wounds. In nearly a quarter of a million admissions dealt with by the medical services, 58.5% of wounds were caused by high-explosive shellfire, 39% by bullets (mostly from machine guns), 2% were caused by grenades, and 0.5% from bayonets.
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Sobral, Vivian Schwaab, Robson Mateus Freitas Silveira, Giovane Debs Guesine, Alessandra Arno, Cristian Marcelo Villegas Lobos, and Iran José Oliveira da Silva. "Transport distance influenced the proportion of skin lesions in finishing pigs and negatively affected animal welfare." Journal of Animal Behaviour and Biometeorology 12, no. 1 (2023): 2024001. http://dx.doi.org/10.31893/jabb.2024001.
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Transport is a relevant process during pigs’ lives because of its impact on animal welfare. Considering commercial conditions, several factors vary between journeys; therefore, it is important to establish the influence of transport distance on skin lesion scores in finishing pigs, considering weather and vibration conditions. Skin lesion score was assessed in 649 finishing pigs at the farms before loading, with a five-point scale (0= none to 4 = ≥ 16 superficial lesions or > 10 deep lesions), and at the slaughterhouse after unloading. Three transport distances were evaluated (short, intermediate and long), in which microclimatic and vibration conditions were monitored from the vehicle’s compartments. Intermediate distances showed higher proportions of worst score (4) at the front part, whereas long distances presented worst score at the middle and hind quarters. Short distances displayed higher proportions of worst score at ears. Temperatures inside the vehicle were above the thermal comfort limit for pigs, providing a heat stress condition. Vibrations were higher sideways than in the vertical and longitudinal directions. Transport under tropical conditions negatively affected the skin injuries score, indicating a higher incidence of skin wounds at the slaughterhouse than in the farms. Body parts can be affected differently by distance, considering skin lesion scores.
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Sherif, Shimaa, Jessica Roelands, William Mifsud, et al. "520 The immune landscape of pediatric tumors." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A556. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0520.
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BackgroundIt is now well established that the immune system has a substantial role in controlling cancer growth and progression. Immunotherapy is quickly coming to the forefront of cancer treatment,however the implementation of immunotherapy in pediatric solid cancers, which classically display a low mutational load, is hindered by insufficient understanding of the determinants of cancer immune responsiveness in children. In order to better understand tumor-host interplay, we sought to characterize solid pediatric cancers based on immunological parameters(1)using analytes extracted from gene expression data.MethodsWe performed single sample GeneSet Enrichment Analysis for 105 immune signatures previously described on 5pediatric tumors (410patients) from TARGET dataset(1) to identify coherent signature modules. Then we clustered samples according to representative signatures (1)and compared survival across clusters. We completed the analysis by analyzing the enrichment of immune subpopulations and the expression of the immune checkpoints. The degree of dysregulation of oncogenic pathways was also assessed. The performance of previously identified immune signatures as the Immunologic Constant of Rejection(2,3),which captures an active Th1/cytotoxic response associated with favorable prognosis and responsiveness to immunotherapy, was also checked within each tumor subtype.ResultsWe found 5main modules, in agreement with results obtained in adult solid tumors:Wound Healing,TGF-B signaling,IFN-G signaling, Macrophages and Lymphocytes (figure 1). These 5 modules clustered pediatric patients into 6 immune subtypes S1-S6 with distinct survival (S2vsS4,p=0.0044, adjusted for cancer type),S2 cluster has the best overall survival and characterized by low enrichment of wound healing signature, high Th1, low Th2 and high expression of HLA 1 and HLA2, while the opposite holds true for cluster S4 with the worst survival and highest enrichment of wound healing signature, high Th2, and low Th1.The S6 cluster is characterized by highest enrichment of lymphocyte signature, the highest expression of immune checkpoints accompanied by elevated expression of exhaustion markers, and an unpolarized immune response with high abundance of macrophages. Additionally, pan-cancer, the upregulation of WNT-Beta catenin pathway is associated with adverse outcome and lack of T-cell infiltration. In the per-cancer analysis, ICR is associated with better survival in osteosarcoma and with worse survival in Wilms’ tumors,similarly with what observed in adult kidney’s cancer despite the different embryological origin.Abstract 520 Figure 1Immune subtypes of pediatric solid tumorsA. Spearman Correlation matrix of 105 cancer immune signatures showing 5 main modules.B. Spearman’s correlation of the 105 cancer immune signatures, identifies separation of the 5 immune signatures in different clustersC. Distribution of cancer types within immune subtypes. The percentage of samples belonging to each tumor is shown in colors.D. Distribution of immune subtypes within TARGET pediatric tumors. The percentage of samples belonging to each immune subtype is shown in colors.E. Distributions of signature scores within the six immune subtypes (rows), with dashed line indicating the median.F. Kaplan-Meier OS curve for the 6 immune subtypes (S1-S6) showing different outcomes.ConclusionsWe demonstrated that pediatric solid cancers can be classified according to their immune disposition, unveiling unexpected similarity with adults’ tumors.Immunological parameters might be explored to refine diagnostic and prognostic biomarkers and to identify potential immune responsive tumors. This is the first pan-cancer immunogenomic analysis in children.ReferencesThorsson V, Gibbs DL, Brown SD, et al. The immune landscape of cancer. Immunity 2018. 48(4):812–830.Roelands J, Hendrickx W, et al. ‘Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response.’ Journal for immunotherapy of cancer 2020;vol. 8:1.Galon J, Angell HK, Bedognetti D, Marincola FM. The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures. Immunity 2013;39:11–26.
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Nechvátal, Luděk. "On a solution of monotone type problems with uncertain inputs." Tatra Mountains Mathematical Publications 48, no. 1 (2011): 145–52. http://dx.doi.org/10.2478/v10127-011-0014-4.
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Abstract The paper deals with a nonlinear weak monotone type problem and its solution with respect to uncertain coefficients in the equation. The so- -called worst scenario method is adopted. The formulation of suitable conditions and a proof of the existence of a solution of the worst scenario problem is presented.
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Dantas Filho, Antonio Medeiros, José Lamartine de Andrade Aguiar, Luís Reginaldo de Menezes Rocha, Ítalo Medeiros Azevedo, Esdras Ramalho, and Aldo Cunha Medeiros. "Effects of the basic fibroblast growth factor and its anti-factor in the healing and collagen maturation of infected skin wound." Acta Cirurgica Brasileira 22, suppl 1 (2007): 64–71. http://dx.doi.org/10.1590/s0102-86502007000700013.
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PURPOSE: The infection is one of the main factors that affect the physiological evolution of the surgical wounds. The aim of this work is to evaluate the effects of fibroblast growth factor (FGFâ) and anti-FGFâ in the healing, synthesis and maturation of collagen when topically used on infected skin wounds of rats. METHODS: An experimental study was perfomed in 60 male Wistar rats. All animals were divided in two groups (A and B). Each group was divided in three subgroups A1, B1; A2, B2 and A3, B3. After anesthesia with pentobarbital, two open squared wounds (1cm²), 4cm distant to each other, were done in the dorsal skin of all the rats. In group A (n=30) the wounds were contaminated with multibacterial standard solution, and in group B(n=30) the wounds were maintained sterile. These wounds were named F1 (for inflammation analysis) and F2 (for collagen study). The open wounds of A1 and B1 rats were topically treated with saline solution, A2 and B2 were treated with FGFâ and subgroups A3 and B3 were treated with FGFâ and anti-FGFâ. The rats were observed until complete epitelization of F2 wounds for determination of healing time and the expression of types I and III collagen, using Picro Sirius Red staining. Inflammatory reaction in F1 wounds was studied using hematoxilineosin staining. The three variable was measured by the Image Pro-Plus Média Cybernetics software. The statistical analysis was performed by ANOVA and Tukey test, considering p<0.05 as significant. RESULTS: It was observed that infection retarded significantly (p<0.05) the time of wound scarring and the topical application of FCFb reverted the inhibition of healing caused by bacteria. The inflammatory reaction was greater in the subgroup B2 than in B1 and A3, and the difference was significant (p<0.05). It was observed greater expression of type I collagen in all the subgroups treated with FCFb, when compared with the untreated subgroups. Type III collagen was significantly decreased in wounds of B3 rats, comparing to the other subgroups. CONCLUSIONS: The FCFb accelerated the healing of open infected wounds and contributed with maturation of collagen, enhancing the type I collagen density. The anti-FCFb antibody was able to attenuate the production of both type I and III collagen.
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Rasik, Anamika M., and Arti Shukla. "Antioxidant status in delayed healing type of wounds." International Journal of Experimental Pathology 81, no. 4 (2001): 257–63. http://dx.doi.org/10.1046/j.1365-2613.2000.00158.x.
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Murata, Yasuhiro, Hidekatsu Yoshiok, Mitsuhíko Kitaok, Ken-ichi Iyama, Ryoichi Okamura, and Gentaro Usuku. "Type VI Collagen in Healing Rabbit Corneal Wounds." Ophthalmic Research 22, no. 3 (1990): 144–51. http://dx.doi.org/10.1159/000267015.
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Yurova, Yu V., E. V. Zinoviev, and K. M. Krylov. "THE METHOD FOR PREDICTING THE TYPE OF SCAR TISSUE IN THE TREATMENT OF BURN WOUNDS." Grekov's Bulletin of Surgery 178, no. 6 (2020): 47–52. http://dx.doi.org/10.24884/0042-4625-2019-178-6-47-52.
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OBJECTIVE. We wanted to relate the perfusion index (M) in burn wound in the period of treatment with the development of the type of pathological scar tissues of different origin during the convalescence period. METHODS AND MATERIALS. We studied burn wounds and scars in 25 patients with thermal trauma in the postoperative period and the convalescence period during the year. We determined the values of perfusion of burn wounds with help of laser Doppler flowmetry, which were diagnostically significant for predicting the outcome of treatment of burn wounds. RESULTS. If the perfusion index was lower than 4.0 PU and higher than 10 PU, then a high risk of developing the pathological type of scar tissue was predicted. If the perfusion index was between 4.0 and 10 PU, then a minimal risk of developing the pathological type of scar tissue was predicted. CONCLUSION. The perfusion index is an important criterion for choosing early preventive measurements and specialized treatment of burn wounds to reduce probable developing the pathological scars and, as a result, obtaining good cosmetic and functional effects. Based on the results of the study, we developed the diagnostic algorithm for predicting the development of various types of scar tissue. Keywords: deep burns, predicting the type of scars, scars, microcirculation, laser Doppler flowmetry, burn wound, outcome of treatment of burn wounds
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Dámaso Fernández-Ginés, Carmen Selva-Sevilla, Manuel Cortiñas-Sáenz, and Manuel Gerónimo-Pardo. "Occupational exposure to sevoflurane following topical application to painful wounds." La Medicina del Lavoro 110, no. 5 (2019): 363–71. https://doi.org/10.23749/mdl.v110i5.8364.
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Background: Occupational exposure to halogenated anesthetics employed for general anesthesia has been extensively studied. Conversely, a new modality of treatment of painful wounds with topical sevoflurane lacks exposure studies. Objectives: To evaluate the magnitude of acute occupational exposure to sevoflurane following topical application to painful wounds. Methods: Four patients with chronic painful wounds were treated with topical sevoflurane (20, 20, 20 and 10 mL) following an approved therapeutic protocol in our Pain Management Unit. Eight passive dosimeters were placed at different locations of a treatment room with a volume of 163 m3 and 3.3 air changes per hour: 3 for near peak (for 20-50 min) and 1 overall exposure (for 3.4 h) at the nurse’s breathing zone, and 4 for area exposure (for 3-3.4 h). Worst-case scenario theoretical concentrations of sevoflurane were also calculated. Results: The highest levels were obtained for two dosimeters worn by the nurse at the breathing zone (8.28 and 9.12 ppm-TWA [parts per million-Time-Weighted Average]), while the lowest level was obtained from the dosimeter placed on the most distant wall from patients (0.73 ppm-TWA). Theoretical concentrations were calculated from standard volatilization principles and were in agreement with the concentrations measured. Discussion-Conclusions: All air concentrations measured were lower than exposure limits set by occupational safety agencies from Finland, Sweden and Norway, which range from 10 ppm for a TWA of 8 hours to 20 ppm for short-term exposures (15 min). Application of topical sevoflurane on wounds seems to be environmentally safe for health-care professionals as it produces exposure levels lower than the established limits for anesthetic procedures.
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Sriwiyati, Lilik, and Budi Kristanto. "Karakteristik Luka Dan Penggunaan Balutan Luka Modern." Adi Husada Nursing Journal 6, no. 1 (2020): 8. http://dx.doi.org/10.37036/ahnj.v6i1.161.
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Abstract
 The most frequent injuries are chronic wounds, where the number is increasing every year. The most common type of wound is diabetic ulcer and the next is cancerous wound. Each wound has different characteristics, so the treatment of each wound is also different. There are various dressings in modern wound care, where each bandage has different indications according to the characteristics of the wound, it is necessary to do research on the characteristics of the wound and the use of modern wound dressing. The purpose of the study To describe the characteristics of wounds and the use of modern wound dressing in the Salud Wound Care Clinic, Kartasura. Research subjects: patients undergoing wound care at the Salud Wound Care Clinic, a total of 9 respondents. Method: Descriptive analytic. Research Results: The types of wounds treated were diabetic ulcer wounds, postoperative wounds, cancer wounds, and decubitus wounds, wound duration varied from 2 weeks to 1 year. Types of wound dressing used were foam, alginate, and hybrid technology dressing, there was a decrease the size of the wound area with a mean of 14,69 to 11,61, the majority of wounds in stage 2, the basic color of the wound is red, and the type of exudate is serous. Conclusion: There is a reduction in wound size, stage, and the wound exudate, as well as repairing the wound’s basic color with wound care using modern wound dressing.
 Keywords: modern wound dressing, wound characteristics.
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Kim, Jane H., Julianna Dong, Brandon H. Le, et al. "Pseudomonas aeruginosa Activates Quorum Sensing, Antioxidant Enzymes and Type VI Secretion in Response to Oxidative Stress to Initiate Biofilm Formation and Wound Chronicity." Antioxidants 13, no. 6 (2024): 655. http://dx.doi.org/10.3390/antiox13060655.
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Pseudomonas aeruginosa (PA) is an opportunistic pathogen frequently isolated from cutaneous chronic wounds. How PA, in the presence of oxidative stress (OS), colonizes chronic wounds and forms a biofilm is still unknown. The purpose of this study is to investigate the changes in gene expression seen when PA is challenged with the high levels of OS present in chronic wounds. We used a biofilm-forming PA strain isolated from the chronic wounds of our murine model (RPA) and performed a qPCR to obtain gene expression patterns as RPA developed a biofilm in vitro in the presence of high levels of OS, and then compared the findings in vivo, in our mouse model of chronic wounds. We found that the planktonic bacteria under OS conditions overexpressed quorum sensing genes that are important for the bacteria to communicate with each other, antioxidant stress genes important to reduce OS in the microenvironment for survival, biofilm formation genes and virulence genes. Additionally, we performed RNAseq in vivo and identified the activation of novel genes/pathways of the Type VI Secretion System (T6SS) involved in RPA pathogenicity. In conclusion, RPA appears to survive the high OS microenvironment in chronic wounds and colonizes these wounds by turning on virulence, biofilm-forming and survival genes. These findings reveal pathways that may be promising targets for new therapies aimed at disrupting PA-containing biofilms immediately after debridement to facilitate the treatment of chronic human wounds.
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Singh, G., and Y. Zinder. "Worst-case performance of critical path type algorithms." International Transactions in Operational Research 7, no. 4-5 (2000): 383–99. http://dx.doi.org/10.1111/j.1475-3995.2000.tb00206.x.
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Supriadi, Supriadi. "Efektivitas Terapi Ozone terhadap Penyembuhan Luka Kaki Diabetik pada Pasien DM Tipe II." Journal of Telenursing (JOTING) 6, no. 1 (2024): 1250–58. http://dx.doi.org/10.31539/joting.v6i1.9792.
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This study aims to analyze the effectiveness of ozone therapy in healing diabetic foot wounds in type II DM patients. The research method used is quasi-experimental with a two-group pretest control group design approach. The research instruments used were the Bates-Jensen Wound Assessment Tool (BWAT) and SOP for ozone therapy and wound care. Data were analyzed using the paired sample T-test and the independent sample T-test. The research results obtained were a bivariate analysis of the paired sample T-test in the intervention group with values of t=11.945 and p=0.003 and in the control group values of t= -5.705 and p=0.000. The results of the independent t-test obtained a value of t = -8.581 and p = 0.001, so it can be stated that ozone therapy is effective in healing diabetic foot wounds in type II DM patients at the Bone Woundcare Center, South Sulawesi. In conclusion, ozone therapy is effective in healing diabetic foot wounds in type II DM patients. Keywords: Diabetes Mellitus, Foot Wounds, Ozone Therapy.