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Journal articles on the topic 'Wound Healing Bioactive Substant natural Formulation'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Ruturaj, Pawar* Akshata Deshmukh. "Formulation and Evaluation of Antibiotic Wound Healing Using Mitragyna Parvifolia: A Review." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 966–81. https://doi.org/10.5281/zenodo.15350926.

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Mitragyna parvifolia is an ethnomedicinal herb with significant potential as a natural wound-healing agent, especially in the context of increasing antibiotic resistance. Traditional use of this plant in folk medicine supports its therapeutic relevance, and modern research has highlighted its antibacterial, anti-inflammatory, antioxidant, and regenerative properties. The plant's bioactive constituents’ alkaloids, flavonoids, and triterpenoids play critical roles in inhibiting bacterial growth, reducing oxidative stress, and enhancing collagen synthesis. These compounds contribute to the

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Aniket, Ade* Rushikesh Mahajan Pranjal Aher Khanderao Jadhav Rishikesh Bacchav. "Natural Bioactive Compound Loaded Nanomaterials for Wound Healing." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3198–216. https://doi.org/10.5281/zenodo.15463541.

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Wound healing is a complex biological process involving haemostasis, inflammation, proliferation and remodelling. Conventional wound treatments, including topical antibiotics and dressings, often fail to provide sustained therapeutic effects, leading to poor patient compliance and increased risk of antimicrobial resistance. Recent advancements have highlighted the potential of natural bioactive compounds, derived from plants, marine organisms, and animals, for wound management due to their antioxidant, anti-inflammatory, antimicrobial, and angiogenic properties. However, the therapeutic applic

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Alsareii, Saeed Ali, Javed Ahmad, Ahmad Umar, Mohammad Zaki Ahmad, and Ibrahim Ahmed Shaikh. "Enhanced In Vivo Wound Healing Efficacy of a Novel Piperine-Containing Bioactive Hydrogel in Excision Wound Rat Model." Molecules 28, no. 2 (2023): 545. http://dx.doi.org/10.3390/molecules28020545.

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These days an extensive amount of the attention of researchers is focused towards exploring bioactive compounds of natural or herbal origin for therapeutic intervention in different ailments of significant importance. One such novel bioactive compound that has a variety of biological properties, including anti-inflammatory and antioxidant activities, is piperine. However, until today, piperine has not been explored for its potential to improve inflammation and enhance healing in acute and chronic wounds. Therefore, the present study aimed to investigate the wound healing potential of piperine

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Ghude, Punam Kisan, Vaishali Pandurang Kandalkar, Tejal Kaluram Bhoir, Sarika Sanjay Nimase, and Prashant Gajanan Bhoir. "Wound-healing effects of curcumin and its nano formulation." IP International Journal of Comprehensive and Advanced Pharmacology 9, no. 2 (2024): 109–15. http://dx.doi.org/10.18231/j.ijcaap.2024.016.

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Wound healing is a method of tissue repair or regeneration. Section Damages. Plants and plant-derived bioactive substances have been found effective in the treatment of many diseases. Types of wounds. Curcumin is a natural polyphenol that has been used since ancient times. Ayurveda is used times for its healing properties to relieve pain and aid in many healing processes. Plates. Various studies of curcumin administration to the site of pain have reported the following effects: Curcumin eliminates reactive oxygen species and increases the ability to improve collagen deposition, Chapter: Granul

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Cavalu, Simona, Paula Melania Pasca, and Marcel Brocks. "Natural Polymeric Film Encapsulating Propolis Nano-Formulation for Cutaneous Wound Healing." Materiale Plastice 56, no. 3 (2019): 479–83. http://dx.doi.org/10.37358/mp.19.3.5213.

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The present paper describe the production and characterization of novel collagen films containing propolis encapsulated in chitosan nanoparticles, for biomedical applications such as cutaneous wound healing. Structural and morphological details were investigated by ATR FTIR spectroscopy, SEM and nanoindentation measurements, revealing the collagen fibers aligned in a quasi-parallel distribution, which might be favorable for biomedical applications. Moreover, the vibrational marker bands of propolis were well preserved in the final polymeric mixture, indicating the stability of bioactive compou

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Samiksha, Wankhade* Aditi Tikait Dr. Swati Deshmukh Pallavi Wagh. "Ginger Extract as A Natural Antimicrobial in Bandage Formulation." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2104–13. https://doi.org/10.5281/zenodo.15396657.

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This study aims to evaluate the antimicrobial efficacy of ginger extract when incorporated into bandage materials and to explore its potential as a natural alternative to synthetic antimicrobial agents commonly used in wound care products. The emergence of multidrug-resistant (MDR) pathogens and increased incidences of chronic wounds have driven research toward natural plant-based antimicrobial agents for wound management. Ginger (Zingiber officinale) a rhizomatous herbaceous plant has been widely used in traditional medicine for its broad-spectrum antimicrobial and anti-inflammatory propertie

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Zeba Fatima and Archana Jorge. "Innovative wound therapy: The role of herbal nano formulations." World Journal of Advanced Research and Reviews 23, no. 3 (2024): 1006–35. http://dx.doi.org/10.30574/wjarr.2024.23.3.2646.

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Wound healing is a complex process, and the management of wounds is a challenge. Herbal remedies have now become essential for the management of wound. Various herbal preparations have been reported to speed up the process of wound healing having anti-microbial activity, antioxidant and anti-inflammatory to improving epithelization, neovascularization, formation of granulation tissue, collagen synthesis, and wound contraction. Many single-herb and multi-plant extract preparations have been reported to accelerate wound healing activity in freshly prepared incisional and excisional experimental

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Zeba, Fatima, and Jorge Archana. "Innovative wound therapy: The role of herbal nano formulations." World Journal of Advanced Research and Reviews 23, no. 3 (2024): 1009–35. https://doi.org/10.5281/zenodo.14938003.

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Wound healing is a complex process, and the management of wounds is a challenge. Herbal remedies have now become essential for the management of wound. Various herbal preparations have been reported to speed up the process of wound healing having anti-microbial activity, antioxidant and anti-inflammatory to improving epithelization, neovascularization, formation of granulation tissue, collagen synthesis, and wound contraction. Many single-herb and multi-plant extract preparations have been reported to accelerate wound healing activity in freshly prepared incisional and excisional experimental

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Nagargoje, MaheshAbhiman, Namrata Hemant Chaudhari, Dikshant Ravindra Khanderao, and Vinayak SanjayHirwe. "Formulation and Evaluation of Polyherbal Gel Using Catharanthus roseus for Wound Healing Activity." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 1626–35. https://doi.org/10.35629/4494-100116261635.

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This research aimed to develop a wound-healing gel using the methanolic extract of Catharanthus roseus (Madagascar periwinkle), rich in therapeutic alkaloids. The study focused on formulating the gel, analyzing its physicochemical properties, and evaluating its antibacterial efficacy, particularly against Staphylococcus aureus, as a natural wound care alternative. Catharanthus roseus leaves were obtained from Ch. Sambhajinagar, Maharashtra, India. A methanolic extraction was carried out using maceration and sonication techniques. To identify the presence of alkaloids, flavonoids, tannins, and

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Alsareii, Saeed Ali, Javed Ahmad, Ahmad Umar, et al. "Healing Efficacy of Hesperetin-Containing Chitosan Gel in Burn Wound: Formulation Design and In Vivo Evaluation." Journal of Biomedical Nanotechnology 18, no. 12 (2022): 2877–85. http://dx.doi.org/10.1166/jbn.2022.3501.

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More than 5 million people require medical attention due to burn-related injuries annually. Significant research has been carried out in recent decades to develop approaches to improve the healing of burn wounds. The focus has also been on the development of natural product-based therapeutic remedies for the treatment of burn wounds. This has been done primarily due to multimodal mechanisms exhibited by some promising bioactive molecules of natural origin. Hesperetin is one such molecule that possesses strong anti-inflammatory and antioxidant properties. It is mainly obtained from citrus speci

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Nam, Da-Ye, Jin Woo, Youngtae Kim, JungHoon Chae, Young-Shin Lee, and Ji-Youl Jung. "Development of Hydrogel Sun Patch with Wound Healing Efficacy." Journal of Wound Management and Research 21, no. 1 (2025): 10–17. https://doi.org/10.22467/jwmr.2024.03118.

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Background: This study focuses on the development of a hydrogel wound patch incorporating natural extracts, designed to function as a sun patch. By maintaining a moist environment and delivering bioactive compounds, the patch promotes wound healing while also providing cooling and ultraviolet (UV) protection. This dual-purpose approach enhances skin recovery and shields damaged areas from external stressors. The study aims to optimize the formulation and evaluate its efficacy for both therapeutic and cosmetic applications.Methods: Hydrogel solutions prepared using acrylamide, glycerol, and car

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Priyanka, Devarshi* Megha Tone. "Formulation and Evaluation of Herbal Transdermal Patch in the treatment of Wound Healing." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 3073–86. https://doi.org/10.5281/zenodo.14551641.

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Transdermal patches deliver medication more directly to the bloodstream by passing processing in the liver. Transdermal patches deliver medication over a longer period of time than traditional systems, which can be easier on patients who experience extreme side effects provides a pre-prescribed dose of medication that is absorbed through the skin and into the bloodstream. The plant Curcuma longa linn (Zingi beraceae) commonly called as Indian Sauron. The whole plant of turmeric mainly rhizomes, roots and leaves are used for medicinal purposes. Rhizomes and roots are playing an important role i

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Kumar, M., Meena Kurup, and J. Jayaprakash. "Design and Optimization of Herbal Formulations in Silver Nanoparticles to Enhance Wound Healing Activity." Journal of Physics: Conference Series 2801, no. 1 (2024): 012014. http://dx.doi.org/10.1088/1742-6596/2801/1/012014.

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Abstract Wound healing is a biological process that involves a series of consecutive process, and its impairment can lead to chronic wounds and various complications. Recently, there has been a growing interest in employing nanotechnology to enhance wound healing. Silver nanoparticles (AgNPs) have expanded significant attention due to their wide range of applications in the medical field. The advantages of AgNPs include their easy synthesis, change their shape, and high surface area. Silver nanoparticles are very efficient for topical drug administration and wound healing because of their high

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Swamini, Kute* Harsh Meher Swapnil Kale. "Formulation and Optimization of Natural Anti-Inflammatory Cream Using Herbal Extract." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1927–46. https://doi.org/10.5281/zenodo.12930773.

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This research explores the therapeutic potential and cosmetic applications of four key medicinal plants: turmeric (Curcuma longa L.), ginger (Zingiber officinale), lavender (Lavandula angustifolia), and aloe Vera (Aloe barbadensis Miller). Each plant is renowned for its distinct bioactive compounds and traditional uses in medicine across cultures, particularly in the Indian subcontinent. Turmeric, with its curcuminoids, is valued for its anti-inflammatory properties and skin-brightening effects. Ginger offers gingerols and shogaols, contributing to its anti-inflammatory and digestive benefits.

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Shivprasad, Chate* Dhanashree Cholke Mayur Bhosle. "Development And Evaluation of Polyherbal Ointment Containing Tridex Procumbens." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1087–104. https://doi.org/10.5281/zenodo.15354499.

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The increasing demand for natural wound care products has led to the exploration of polyherbal formulations that combine the therapeutic benefits of multiple medicinal plants. This study aimed to develop and evaluate a polyherbal ointment containing ethanolic extracts of Tridax procumbens, Ocimum sanctum (Tulsi), Curcuma longa (Turmeric), and Azadirachta indica (Neem) — all renowned for their antimicrobial, anti-inflammatory, antioxidant, and wound healing properties. The ointment was formulated using a standard ointment base and subjected to comprehensive evaluation, including physicoch

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Algahtani, Mohammed S., Mohammad Zaki Ahmad, Ibrahim Ahmed Shaikh, Basel A. Abdel-Wahab, Ihab Hamed Nourein, and Javed Ahmad. "Thymoquinone Loaded Topical Nanoemulgel for Wound Healing: Formulation Design and In-Vivo Evaluation." Molecules 26, no. 13 (2021): 3863. http://dx.doi.org/10.3390/molecules26133863.

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Thymoquinone is a natural bioactive with significant therapeutic activity against multiple ailments including wound healing. The poor aqueous solubility and low skin permeability limit its therapeutic efficacy. The present investigation aimed to improve the biopharmaceutical attributes of thymoquinone to enhance its topical efficacy in wound healing. A nanoemulsion-based hydrogel system was designed and characterized as a nanotechnology-mediated drug delivery approach to improve the therapeutic efficacy of thymoquinone, utilizing a high-energy emulsification technique. The black seed oil, as a

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Vaishnavi, Surve* Aditi Tikait Dr. Swati Deshmukh. "Tridax Procumbens Herbal Soap: A Natural Remedy for Skin Health." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2783–95. https://doi.org/10.5281/zenodo.15444520.

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Herbal medicines have long been integral to traditional healing systems due to their high medicinal value, availability, cost-effectiveness, and compatibility with human health. Among these, Tridax procumbens, commonly known as coat buttons, has gained considerable attention for its therapeutic potential in treating various skin disorders. This study focuses on the formulation and evaluation of a herbal soap incorporating Tridax procumbens extract, aiming to provide a natural, effective alternative to chemical-based commercial soaps. Herbal soaps offer numerous benefits, including antibacteria

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Sanjivani, Talekar* Prachi Murkute Ashwini Pundkar Dr. Santosh Payghan. "Formulation And Evaluation of Herbal Antimicrobial Gel." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1803–14. https://doi.org/10.5281/zenodo.15221266.

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Antimicrobial gels are essential in combating microbial infections, promoting wound healing, and ensuring hygiene in various medical and personal care applications. This study focuses on the formulation and evaluation of an antimicrobial gel incorporating bioactive agents such as essential oils, metal nanoparticles, or synthetic antibiotics. The gel was assessed for its physicochemical properties, antimicrobial efficacy, and stability. Results demonstrated significant inhibition of bacterial and fungal growth, indicating its potential as a broad-spectrum antimicrobial agent. The formulation ex

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Mani, Sangeetha, and Anantharaj Veeraputhiran. "Design and Assessment of Boswellia Nanofibers for Diabetes Wound Healing." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 01 (2024): 169–73. http://dx.doi.org/10.25258/ijddt.14.1.24.

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Diabetic wounds present a major healthcare challenge because they frequently result in serious side effects and chronic, non-healing ulcers. The application of nanotechnology in the creation of sophisticated wound dressings has demonstrated encouraging outcomes in accelerating the healing of wounds. Particularly, nanofiber-based dressings have drawn interest because of their large surface area, porosity, and capacity to replicate the extracellular matrix, which creates the perfect surroundings for attachment of cells, growth, and differentiation. This review emphasizes the various materials an

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Dr. L.D Hingane Sir, Dr L. D. Hingane Sir, Ms Jingure Shruti Maroti, and Ms Kemdharne Aishwarya A. "Preparation and evaluation of wound healing cream of Tridax Procumbene." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 312–17. https://doi.org/10.35629/4494-0906312317.

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Tridax procumbens, commonly known as coatbuttons or tridax daisy, is a species of flowering plant in the family Asteraceae. India’s fields are home to a prevalent weed called Tridax procumbens. Ancient ages have long utilized the leaves of Tridax procumbens to cure wounds. The mature leaves were crushed to make a paste and were further rubbed over the wounded area. They are also used as anticoagulant, antifungal and insect repellent by many civilization. Tridax procumbenslinn. Strongly proved for its antiinflammatory and analgesic activity in animal study and it is also used to treat boils , b

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Raj, Piyush, Neha Sodiyal, and Shivanand M. Patil. "Preparation and Evaluation of Herbal Oral Gel Containing Extract of Psidium guajava Leaves for Mouth Ulcer." Journal for Research in Applied Sciences and Biotechnology 3, no. 6 (2024): 116–25. https://doi.org/10.55544/jrasb.3.6.15.

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Mouth ulcers are a common oral condition causing discomfort and pain, often interfering with daily activities like eating and speaking. Conventional treatments, such as synthetic gels and medications, can sometimes result in side effects or high costs, which has led to growing interest in natural and herbal alternatives. Herbal formulations are known for their safety, affordability, and effectiveness. Psidium guajava (guava) leaves have been widely recognized in traditional medicine for their antimicrobial, anti-inflammatory, and wound-healing properties. Rich in bioactive compounds such as fl

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Ponphaiboon, Juthaporn, Wantanwa Krongrawa, Wah Wah Aung, Nawinda Chinatangkul, Sontaya Limmatvapirat, and Chutima Limmatvapirat. "Advances in Natural Product Extraction Techniques, Electrospun Fiber Fabrication, and the Integration of Experimental Design: A Comprehensive Review." Molecules 28, no. 13 (2023): 5163. http://dx.doi.org/10.3390/molecules28135163.

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The present review explores the growing interest in the techniques employed for extracting natural products. It emphasizes the limitations of conventional extraction methods and introduces superior non-conventional alternatives, particularly ultrasound-assisted extraction. Characterization and quantification of bioactive constituents through chromatography coupled with spectroscopy are recommended, while the importance of method development and validation for biomarker quantification is underscored. At present, electrospun fibers provide a versatile platform for incorporating bioactive extract

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Susmita, Khamaru Anuranjita Kundu*. "Exploring The Antimicrobial Potential of Herbal Formulation of Clerodendrum Infortunatum." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1189–96. https://doi.org/10.5281/zenodo.15186974.

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Antimicrobial resistance is a pressing global challenge, necessitating the exploration of novel bioactive compounds from natural sources. Among these, Clerodendrum infortunatum, a species widely distributed in tropical and subtropical regions has its significant antimicrobial properties. Its leaves have properties including antibacterial, wound healing, treatment of different skin diseases and snake bites. Recent studies have revealed the leaves are rich in bioactive compounds such as terpenoids, phenolic acids and glycosides, which contribute to its antimicrobial properties. In this study, th

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Pathan, Irfan Mustafa, Vishal S. Madankar, and Anil B. Panchal. "Formulation and Evaluation of Guava Leaf-Based Nanogel for Mouth Ulcer Treatment." Journal of Drug Delivery and Therapeutics 15, no. 4 (2025): 13–19. https://doi.org/10.22270/jddt.v15i4.7069.

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Mouth ulcers, also known as aphthous ulcers, are painful lesions affecting the oral mucosa, causing discomfort and irritation. Conventional treatments, such as antiseptic gels and corticosteroids, provide temporary relief but may have side effects with prolonged use. Guava leaves (Psidium guajava) contain bioactive compounds such as flavonoids, tannins, and polyphenols, which exhibit antimicrobial, anti-inflammatory, and wound-healing properties. This study focuses on the formulation of a simple, Nanogel using Carbopol 934 as a base for the treatment of mouth ulcers. The gel was prepared by in

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Singh, Mr Pratap, Harsh Kumar, Gurdev Gurdev, Hemlata Hemlata, and Harshit Parmar. "“Review on Herbal Formulation of Aloe Vera Herbal Gel and Its Potential Benefits”." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 1334–40. https://doi.org/10.35629/4494-100213341340.

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Aloe Vera Herbal Gel, a Multifaceted Natural Therapeutic Agent, holds a significant position in natural remedies, derived from the parenchymatous tissue of the Aloe barbadensis Miller plant, a species with a rich history of therapeutic application spanning centuries. Its popularity stems from a diverse array of therapeutic properties, meticulously studied and traditionally recognized. At its core, Aloe Vera gel boasts a complex biochemical composition, a key factor underpinning its biological activities. This translucent gel is a reservoir of vital polysaccharides, notably acemannan, alongside

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Sakkariya, KN, MV Habeebulla, Jisha Dev, TV Jinitha, NK Hashim, and Muhamned Kutty PV. "Chemical Profiling, Spectroscopic Characterization and Biological Evaluation of a novel polyherbal formulation with natural binders- Ayurgreen Natura Pain Gel." Journal of Ayurvedic and Herbal Medicine 8, no. 2 (2022): 72–84. http://dx.doi.org/10.31254/jahm.2022.8204.

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Introduction: Herbal compositions are becoming increasingly important in today's world of raw material scarcity. Polyherbal formulations exhibit high efficacy due to the presence of active phytochemicals which may enhance their potency due to the synergetic interaction of active ingredients of different plants. Ayurgreen Natura Pain Gel is an important Ayurvedic polyherbal formulation prepared using specified plant parts of dried aloe vera and fresh aloe vera pulp, frankincense, myrrh, ferula asafetida. Methods: The phytochemistry of Ayurgreen Natura Pain Gel has been evaluated using a liquid

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Besrour, Nermine, Taofiq Oludemi, Filipa Mandim, et al. "Valorization of Juglans regia Leaves as Cosmeceutical Ingredients: Bioactivity Evaluation and Final Formulation Development." Antioxidants 11, no. 4 (2022): 677. http://dx.doi.org/10.3390/antiox11040677.

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The cosmetic industry is constantly searching for bioactive ingredients, namely, those obtained from natural sources with environmentally friendly connotations and less toxic effects. A previous study of our research group optimized the extraction of phenolic compounds from Juglans regia by heat-assisted extraction. Due to its richness in different phenolic compounds, the present work aimed to develop a formulation containing J. regia leaf extract. The extract’s antioxidant, anti-tyrosinase, antimicrobial, anti-inflammatory, wound healing, cytotoxicity, and photostability properties were evalu

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Kamthe, Mr Prathamesh. "A Review: Preparation and Evaluation of Herbal Foot Cream by using Tridax Procumbens Extract." International Journal for Research in Applied Science and Engineering Technology 13, no. 4 (2025): 5369–74. https://doi.org/10.22214/ijraset.2025.69604.

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Abstract: The growing demand for natural and sustainable skincare solutions has led to increased interest in herbal formulations for foot care. Foot creams enriched with plant extracts offer therapeutic benefits while minimizing the side effects associated with synthetic ingredients. Tridax procumbens, a medicinal plant with well-documented antimicrobial, antiinflammatory, and wound-healing properties, presents a promising candidate for developing an effective herbal foot cream. This review explores the preparation methods, formulation strategies, and pharmacological evaluation of Tridax procu

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Dahiya, Divakar, Caoimhin Mackin, and Poonam Singh Nigam. "Studies on bioactivities of Manuka and regional varieties of honey for their potential use as natural antibiotic agents for infection control related to wound healing and in pharmaceutical formulations." AIMS Microbiology 10, no. 2 (2024): 288–310. http://dx.doi.org/10.3934/microbiol.2024015.

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<abstract> <p>Presently, most of the reported infections are of a bacterial origin; however, this leads to a limit within the literature and research around infections caused by fungal pathogens, which are now developing resistance to antibiotic medicines. Of the natural antimicrobial agents, honey has been observed with demonstrable and highly exploitable antimicrobial and infection control related to wound healing properties; therefore, it has been incorporated into many standard pharmaceutical formulations. Generally, these products utilize a pure sample of honey as a bioactive

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Pranjali D. Gadhave and Bhavana D. Tambe. "Development of a Nutraceutical Tablet for prevention of thrombocytopenia." International Journal of Science and Research Archive 14, no. 2 (2025): 1748–53. https://doi.org/10.30574/ijsra.2025.14.2.0540.

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The growing prevalence of thrombocytopenia has created a critical need for safe, effective, and affordable treatment alternatives. Thrombocytopenia, characterized by a decreased platelet count, can result from various causes, including viral infections, autoimmune disorders, and bone marrow dysfunction. It increases the risk of severe bleeding, delayed wound healing, and immune system compromise. Medicinal plants have been widely used in traditional medicine systems for managing various health disorders. Among them, Carica Papaya (papaya) and Murrayakoenigii (curry leaves) have gained attentio

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Adnan Bodlah, Muhammad, Ayesha Younas, Alishbah Mohsin, et al. "THE STATE OF SAFETY AND QUALITY OF HONEYBEE BY-PRODUCTS: A REVIEW." Malaysian Animal Husbandry Journal 3, no. 2 (2023): 66–72. http://dx.doi.org/10.26480/mahj.02.2023.66.72.

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Bee honey has been regarded as a prized and esteemed natural substance by humans since antiquity. The historical significance of bee products lies in their recognized medicinal properties, which have been appreciated for centuries. The utilization of bee products, such as honey, bee venom, beeswax, royal jelly, propolis, bee-collected pollen, and bee bread, as natural medicines is on the rise. This is due to the fact that they contain a high number of bioactive compounds, possess beneficial health properties, and are known for their effective healing capabilities. Apiarian products are highly

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Baptista, Sílvia, João R. Pereira, Cátia V. Gil, Cristiana A. V. Torres, Maria A. M. Reis та Filomena Freitas. "Development of Olive Oil and α-Tocopherol Containing Emulsions Stabilized by FucoPol: Rheological and Textural Analyses". Polymers 14, № 12 (2022): 2349. http://dx.doi.org/10.3390/polym14122349.

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Biobased raw materials like natural polysaccharides are increasingly sought by the cosmetic industry for their valuable properties. Such biodegradable and usually non-cytotoxic biopolymers are commonly used in skin-care products as rheological modifiers, bioemulsifiers and/or bioactive ingredients. FucoPol is a natural polysaccharide with reported biocompatibility, emulsion-forming and stabilizing capacity, shear-thinning behavior and bioactivity (e.g., antioxidant capacity, wound healing ability) that potentiate its utilization in skin-care products. In this study, olive oil and α-tocopherol

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Rani, Jyoti, Ramratan Guru, Jaswant Singh, and Sakthivel Santhanam. "Eco-Dyeing and Functional Finishing of Cotton Fabric Using a Natural Colour Derived From Lotus Seed: Enhanced Fastness Properties with Chitosan." Textile & Leather Review 7 (June 11, 2024): 1039–60. http://dx.doi.org/10.31881/tlr.2024.099.

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Medicinal plant-based dyeing introduces vibrant colours alongside antibacterial and anti-odor properties, fostering sustainability. Innovations include mass sampling for consistent pigment production. Furthermore, lotus seedpods, rich in bioactive compounds, exhibit potential in diverse fields. Chitosan, a biopolymer derived from chitin, boasts versatility in drug delivery systems, wound healing, and antimicrobial applications. This experimental inquiry delves into the dyeability and antimicrobial efficacy of cotton fabric subjected to treatment with chitosan and dyed using Lotus seeds. The in

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Azevedo, Filipe Silveira, Allan Rodrigues Pires, Mary Ann Lila, et al. "Berry Fruit Extracts as Topical Cosmeceuticals for Skin Health Applications: A Systematic Review." Cosmetics 12, no. 3 (2025): 87. https://doi.org/10.3390/cosmetics12030087.

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Berries are a popular source of natural bioactive compounds with distinctive aspects and sensory attributes. In this review, the term “berry” refers to generally round, small, colorful, and juicy fruits with English common names ending in “berry”. They have high phenolic content, which has been linked to their health-relevant properties. To gather information on the potential of berries for treating skin inflammatory diseases, this systematic review was conducted following PRISMA guidelines (PROSPERO registration number CRD 42024549567), based on studies from PubMed, Scopus, Web of Science, an

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Krishna Sailaja, Abbaraju. "An Article on Curcumin Loaded Transferosomes as A Novel Drug Delivery System." General medicine and Clinical Practice 7, no. 1 (2024): 01–06. http://dx.doi.org/10.31579/2639-4162/122.

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Curcumin is a natural compound found in turmeric and has shown potential in treating a variety of diseases due to its anti-inflammatory and antioxidant properties. However, curcumin has low bioavailability and poor solubility in water, which limits its therapeutic efficacy. Transferosomes are specialized lipid vesicles that can encapsulate drugs and other bioactive molecules, allowing them to be delivered to specific target tissues. Curcumin, a natural compound found in turmeric, has been the subject of intense study due to its potential health benefits, including anti-inflammatory and antioxi

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Nagrik, Shatrughna U., Shivshankar M., Vishal S. Chharre, Shubhangi M. Dhage, and Vrushali S. Borey. "Role of aloe vera in skincare: exploring its therapeutic benefits, formulations, and future innovations." Yemen Journal of Medicine 3, no. 3 (2024): 197–206. https://doi.org/10.18231/j.yjom.2024.021.

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One of the most ancient species of the Asphodelaceae family, Aloe barbadensis, known for its medicinal, cosmetic, and therapeutic properties, has been used for thousands of years. The Egyptians called it the "plant of immortality," and the use of this plant in skin care dates back thousands of years to ancient Greece and China, where it had a high esteem for its healing and soothing properties. In the modern world, Aloe vera has become an indispensable ingredient in topical dermatological preparations because of its great variety of bioactive compounds, including vitamins, enzymes, polysacchar

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Nagrik, Shatrughna U., Shivshankar M., Vishal S. Chharre, Shubhangi M. Dhage, and Vrushali S. Borey. "Role of aloe vera in skincare: exploring its therapeutic benefits, formulations, and future innovations." Yemen Journal of Medicine 03, no. 03 (2024): 197–206. https://doi.org/10.63475/j.yjom.2024.021.

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One of the most ancient species of the Asphodelaceae family, Aloe barbadensis, known for its medicinal, cosmetic, and therapeutic properties, has been used for thousands of years. The Egyptians called it the "plant of immortality," and the use of this plant in skin care dates back thousands of years to ancient Greece and China, where it had a high esteem for its healing and soothing properties. In the modern world, Aloe vera has become an indispensable ingredient in topical dermatological preparations because of its great variety of bioactive compounds, including vitamins, enzymes, polysacchar

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Rutuja, Golecha* Dr Vaishali Kate Dr. Santosh Payghan. "Formulation & Evaluation of Herbal Sunscreen in Combination with Olive Oil Useful for Various Skin Benifits." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 3205–17. https://doi.org/10.5281/zenodo.15298967.

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Due to the hasty-paced life of today, our daily routines expose us to pollution and harsh synthetic chemicals, which can have adverse effects on our skin and overall health. Fortunately, nature has provided us with a wealth of powerful herbal ingredients that offer significant protective and restorative benefits. One of the major concerns associated with prolonged sun exposure is the damage caused by ultraviolet (UV) rays, which not only lead to sunburn but can also contribute to the development of precarious skin conditions, including premature aging and skin cancer. Sunscreen serves as a top

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da Silva Melo, Anne Emmanuelle Câmara, Felipe Sanderson Ribeiro de Sousa, Alaine M. dos Santos-Silva, et al. "Immobilization of Papain in Chitosan Membranes as a Potential Alternative for Skin Wounds." Pharmaceutics 15, no. 12 (2023): 2649. http://dx.doi.org/10.3390/pharmaceutics15122649.

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Papain (an enzyme from the latex of Carica papaya) is an interesting natural bioactive macromolecule used as therapeutic alternative for wound healing due to debridement action in devitalized or necrotic tissues. However, its use in high doses can induce potential skin irritation and side effects. In this study, experiments explored the ability of chitosan membrane to immobilize papain, consequently improving enzymatic activity and controlling enzyme release. Papain-loading capacity was tested via experiments of force microscopy (AFM), scanning electron microscopy (SEM-FEG), and X-ray diffract

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Oktay, Büsra, Fatih Ciftci, Azime Erarslan, and Esma Ahlatcıoğlu Özerol. "Dual-Layer Natamycin and Boric-Acid-Reinforced PVA/Chitosan by 3D Printing and Electrospinning Method: Characterization and In Vitro Evaluation." Polymers 17, no. 12 (2025): 1673. https://doi.org/10.3390/polym17121673.

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This study presents the development and comprehensive characterization of biopolymer-based nanofibrous composites composed of polyvinyl alcohol (PVA), chitosan (CS), boric acid (BA), and a natural antifungal agent natamycin (NAT), designed for therapeutic applications. A dual-layer 3D-fiber composite (PVA/CS/BA_PVA/NAT) was successfully fabricated using a layer-by-layer 3D bioprinting technique and electro-spinning, integrating BA into the core matrix and NAT into the outer layer. Mechanical tests revealed a significantly improved elastic modulus of 763.04 ± 14.54 MPa and the highest ultimate

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P.A.M, Sucharitha, Poojitha M, Sravani B, et al. "Preparation and Evaluation of Wound Healing Herbal Ointment." International Journal of Current Innovations in Advanced Research, June 5, 2025, 1–5. https://doi.org/10.47957/ijciar.v8i2.196.

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The use of herbal medicines for wound healing has been widely recognized in traditional practices and modern studies. Wound healing is a complex biological process that involves the restoration of tissue integrity following injury. The use of topical ointments in wound care is a common therapeutic approach to accelerate healing, reduce infection, and minimize scarring. This study explores the formulation and efficacy of a herbal wound healing ointment composed of natural ingredients with antimicrobial, anti-inflammatory, antioxidant and regenerative properties. This research focuses on the for

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Manginstar, Christian Oktavianus, Trina Ekawati Tallei, Nurdjannah Jane Niode, Christina Leta Salaki, and Sofia Safitri Hessel. "Therapeutic potential of propolis in alleviating inflammatory response and promoting wound healing in skin burn." Phytotherapy Research, December 12, 2023. http://dx.doi.org/10.1002/ptr.8092.

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AbstractBurns can cause inflammation and delayed healing, necessitating alternative therapies due to the limitations of conventional treatments. Propolis, a natural bee‐produced substance, has shown promise in facilitating burn healing. This literature review provides a comprehensive overview of propolis' mechanisms of action, wound‐healing properties, and its application in treating skin burns. Propolis contains bioactive compounds with antimicrobial, antioxidant, and anti‐inflammatory properties, making it a promising candidate for managing skin burn injuries. It helps prevent infections, ne

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Bhat, Rama, Deepa PR, and Ravi Rao. "THE EVALUATION OF THE WOUND HEALING PROPERTIES OF METHANOLIC BARK EXTRACT OF SAMADERA INDICA GAERTNER IN VIVO." Asian Journal of Pharmaceutical and Clinical Research, April 11, 2019, 371–74. http://dx.doi.org/10.22159/ajpcr.2019.v12i5.32933.

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Objectives: The exracts of Samadera indica used in traditional medicines for the treatment of skin diseases, rheumatism, cough and to kill head lice.  The main objective of the present study was to evaluate the wound healing activity of methanolic bark extract of Samadera indica. Methods: The bark samples of were collected, allowed to shade dry for a week, then coarsely powdered and was extracted with methanol by soxhlation process. The extract was used for wound healing experiment using excision wound model. 18 healthy Wistar albino rats divided into three groups of six rats each

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Terse, Pratik, Nisarga Latthe, Janhavi Karanjkar, et al. "A Review on the Role of Acacia nilotica in Topical formulation for Skin Therapeutics." Research Journal of Pharmacognosy and Phytochemistry, May 14, 2025, 143–48. https://doi.org/10.52711/0975-4385.2025.00024.

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Acacia nilotica (Linn.), generally known as Babul or Gum Arabic tree, is a multipurpose plant from the Fabaceae family with significant ethnopharmacological importance. It is widely spread in tropical and subtropical regions and used widely in traditional medicine for its remarkable therapeutic properties. This review article explores the botanical features, phytochemical composition, and pharmacological activities of A. nilotica, highlighting its potential role in topical formulations for skin therapeutics. The plant comprises bioactive compounds such as tannins, flavonoids, alkaloids, and es

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Parth, Sudarshan Palamkar. "A Phytotherapeutic Approach to Wound Healing: Evaluation of a Dual-Herb Gel Containing Euphorbia hirta and Tridax procumbens." Advance Research in Pharmacy & Therapeutics 1, no. 5 (2025). https://doi.org/10.5281/zenodo.15364360.

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This study provides an emphasis on the formulation and evaluation of a polyherbal wound healing gel from Euphorbia hirta and Tridax procumbens. The plants are known to have been traditionally used in treating wounds and skin disorders due to their rich phytochemical profile. All tests were performed on gelling properties such as colour, appearance, pH, spreadability, homogeneity, viscosity, stability, and antibacterial activity. From among three developed formulations and completed with the total weight of three batches in which F3 showed the best features, which were a stable pH value of 6.9

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Pradhan, Pooja, Kamran Javed Naquvi, and Neeraj Kumar. "THE MEDICINAL POTENTIAL OF ARNEBIA BENTHAMII IN WOUND HEALING FROM TRADITIONAL USES TO MODERN THERAPEUTICS." EPH - International Journal of Biological & Pharmaceutical Science, 2024. https://doi.org/10.53555/eijbps.v10i1.56.

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Arnebia benthamii, commonly known as Ratanjot, has been traditionally used in herbal medicine for its potent wound-healing properties. This review explores its medicinal potential, tracing its journey from traditional applications to modern therapeutics. Rich in bioactive compounds such as alkannins, flavonoids, and phenolic acids, A. benthamii exhibits antimicrobial, anti-inflammatory, and antioxidant properties that accelerate wound healing. Traditional practices have long utilized its extracts for treating cuts, burns, and ulcers, often in the form of ointments or decoctions. Recent pharmac

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Dr. L. D. Hingane, Ms. Jingure Shruti Maroti, and Ms. Kemdharne Aishwarya A. "Preparation and Evaluation of Wound Healing Cream of Tridax Procumbene." International Journal of Advanced Research in Science, Communication and Technology, November 14, 2024, 282–89. http://dx.doi.org/10.48175/ijarsct-22243.

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Tridax procumbens, commonly known as coatbuttons or tridax daisy, is a species of flowering plant in the family Asteraceae. India’s fields are home to a prevalent weed called Tridax procumbens. Ancient ages have long utilized the leaves of Tridax procumbens to cure wounds. The mature leaves were crushed to make a paste and were further rubbed over the wounded area. They are also used as anticoagulant, antifungal and insect repellent by many civilization. Tridaxprocumbenslinn. Strongly proved for its anti-inflammatory and analgesic activity in animal study and it is also used to treat boils , b

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Ebrahimnejad, Pedram, Paria Fadaee Heydarabadi, Fereshteh Talebpour Amiri, Fatemeh Mirzaee, Melika Ahmadi, and Somayeh Shahani. "Niosome-Based Hydrogel of Quince Extract: A Promising Strategy for Expedited Full-thickness Wound Healing in Rat." Current Drug Delivery 21 (June 4, 2024). http://dx.doi.org/10.2174/0115672018282735240528072715.

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Background: The regeneration of tissue damage involves a series of molecular and cellular events that can be mediated by various natural compounds. Recent studies have highlighted the anti-inflammatory, anti-ulcer, and skin-protecting properties of Cydonia oblonga (Quince), which are mainly attributed to phenolic compounds. These compounds may have some drawbacks when targeting wound applications, including low bioavailability at the wound site. Moreover, to overcome these limitations, surfactant-based nanovesicular systems have been developed as carriers of such compounds for wound healing. O

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Lai‐Foenander, Ashley Sean, Giva Kuppusamy, Janaranjani Manogoran, et al. "Black soldier fly (Hermetia illucens L.): A potential small mighty giant in the field of cosmeceuticals." Health Science Reports 7, no. 6 (2024). http://dx.doi.org/10.1002/hsr2.2120.

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AbstractBackground and AimsNatural products are widely used in the pharmaceutical and cosmetics industries due to their high‐value bioactive compounds, which make for “greener” and more environmentally friendly ingredients. These natural compounds are also considered a safer alternative to antibiotics, which may result in antibiotic resistance as well as unfavorable side effects. The development of cosmeceuticals, which combine the cosmetic and pharmaceutical fields to create skincare products with therapeutic value, has increased the demand for unique natural resources. The objective of this

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Salem, Mohamed A., Osama G. Mohamed, Esraa M. Mosalam, et al. "Investigation of the phytochemical composition, antioxidant, antibacterial, anti-osteoarthritis, and wound healing activities of selected vegetable waste." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-38591-y.

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AbstractAgri-food wastes, produced following industrial food processing, are mostly discarded, leading to environmental hazards and losing the nutritional and medicinal values associated with their bioactive constituents. In this study, we performed a comprehensive analytical and biological evaluation of selected vegetable by-products (potato, onion, and garlic peels). The phytochemical analysis included UHPLC-ESI-qTOF-MS/MS in combination with molecular networking and determination of the total flavonoid and phenolic contents. Further, the antimicrobial, anti-osteoarthritis and wound healing

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