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1
Fedosov, Pavel, Vladimir Nikolaevsky, Yury Chernov, Anna Buzlama, Alexey Slivkin, and Svetlana Provotorova. "PRECLINICAL STUDY OF THE EFFICACY AND SAFETY OF WOUND HEALING GEL CONTAINING CHITOSAN, TAURINE AND ALLANTOIN." Research Results in Pharmacology 3, no. (2) (2017): 14–28. https://doi.org/10.18413/2313-8971-2017-3-2-14-28.
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Introduction: The paper deals with the problem of wound healing, which is considered to remain one of the most pressing challenges of the modern medicine, despite a large variety of wound healing preparations. This results from a high level of domestic and military traumatism of the population, and the fact that many registered medications do not meet the requirements for modern wound healing preparations. Objectives: To develop gel containing chitosan, taurine, allantoin, and to experimentally investigate its wound healing properties in pre-clinical studies on laboratory animals. Methods: The methodological approach was based on a range of theoretical, pharmacological, toxicological, histological, statistical, physico-chemical, biopharmaceutical, rheological methods, which ensured the development of an optimal, safe and effective wound healing preparation in the gel dosage form. Results: The developed chitosan gel containing taurine and allantoin meets the major modern requirements for wound and burn care. Physico-chemical compatibility of the chitosan gel components with taurine and allantoin were proved in the experimental studies. When applied either singly or repeatedly on the skin, the developed gel is reported to be of low toxicity; in case of linear wounds, it demonstrates wound-healing properties, ensuring the increase of wound-disruption strength 1.5 times more in comparison with the control; in case of planar full-thickness skin wounds, it provides earlier complete healing (4 days earlier than in the control) and full epithelium recovery in the area of a wound defect. The given gel possesses burn-treating properties exceeding the efficiency of the "Solcoseryl" gel and reducing the half-healing period by 28%. When applied topically, the chitosan gel containing taurine and allantoin reveals anti-inflammatory and capillary-protective properties of moderate degree. Conclusion: It is possible to use 1.0% chitosan gel with 4.0% taurine and 0.5% allantoin to accelerate healing and provide epithelization without cosmetic defects of conditionally aseptic wounds and thermal skin burns up to IIIa degree to 1% of the body surface area; the gel should be applied 1-3 times a day locally, 0.5 g directly to the wound surface.
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Wolcott, R. "Disrupting the biofilm matrix improves wound healing outcomes." Journal of Wound Care 24, no. 8 (2015): 366–71. http://dx.doi.org/10.12968/jowc.2015.24.8.366.
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Objective: The most unyielding molecular component of biofilm communities is the matrix structure that it can create around the individual microbes that constitute the biofilm. The type of polymeric substances (polymeric sugars, bacterial proteins, bacterial DNA and even co-opted host substances) are dependent on the microbial species present within the biofilm. The extracellular polymeric substances that make up the matrix give the wound biofilm incredible colony defences against host immunity, host healing and wound care treatments. This polymeric slime layer, which is secreted by bacteria, encases the population of microbes, creating a physical barrier that limits the ingress of treatment agents to the bacteria. The aim of this study was to determine if degrading the wound biofilm matrix would improve wound healing outcomes and if so, if there was a synergy between treating agents that disrupted biofilm defenses with Next Science Wound Gel (wound gel) and cidal agents (topical antibiotics). Method: A three-armed randomised controlled trial was designed to determine if standard of care (SOC) was superior to SOC plus wound gel (SOC + gel) and wound gel alone. The wound gel used in this study contains components that directly attack the biofilm extracellular polymeric substance. The gel was applied directly to the wound bed on a Monday–Wednesday–Friday interval, either alone or with SOC topical antibiotics. Results: Using a surrogate endpoint of 50% reduction in wound volume, the results showed that SOC healed at 53%, wound gel healed at 80%, while SOC plus wound gel showed 93% of wounds being successfully treated. Conclusion: By directly targeting the wound biofilm matrix, wound healing outcomes are improved.
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Supachawaroj, Nuttawut, Kunchorn Kerdmanee, and Sucharat Limsitthichaikoon. "Lidocaine-Loaded Thermoresponsive Gel for Accelerated Wound Healing in Dry Socket and Oral Wounds." Gels 10, no. 11 (2024): 739. http://dx.doi.org/10.3390/gels10110739.
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Dry socket, also known as alveolar osteitis, presents significant challenges in oral surgery because of severe pain and delayed wound healing. This study aims to address these challenges by developing and evaluating a lidocaine-loaded polyelectrolyte complex thermoresponsive gel (LG) designed to enhance wound healing and provide effective pain management in oral wounds. The thermoresponsive gel transitions from a liquid to a gel at body temperature, ensuring sustained contact with the wound site and prolonged release of lidocaine. The in vitro assessments, including cytotoxicity and wound scratch assays, demonstrated the biocompatibility and therapeutic potential of the LG formulation. Following this, palatal wounds were induced in rats, with healing monitored over a 14-days period. Histological analyses were conducted to assess tissue regeneration and inflammation. The results indicated that the LG formulation significantly improved wound closure rates, reduced inflammation, and accelerated epithelialization compared with control groups, primarily because of the high content of hyaluronic acid (HA). The synergistic effects of HA combined with the thermoresponsive properties of the gel facilitated faster healing. These findings suggest that LG is a promising therapeutic option for enhancing oral wound healing and effectively managing pain, particularly in conditions such as dry socket.
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Gulyayev, A. E., Z. T. Shulgau, S. D. Sergazy, et al. "Wound healing and anti-inflammatory effects of recombinant human angiogenin." Biological Products. Prevention, Diagnosis, Treatment 22, no. 3 (2022): 293–307. http://dx.doi.org/10.30895/2221-996x-2022-22-3-293-307.
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New effective wound healing agents are a priority for modern clinical pharmacology. A promising approach would be to develop medicinal products that promote angiogenesis, which is a critical step in wound healing. The aim of the study was to evaluate the wound healing effect of a medicinal product based on recombinant human angiogenin in gel form in various experimental models. Materials and methods: white outbred male rats were used as experimental ani mals. The study compared healing effects of a regenerating product containing recombinant human angiogenin (0.0025%) in gel form and a reference product in full-thickness excision, incision, and burn wound models. The healing effect of the test product in treating chronic wounds was assessed in a model of alloxan-induced diabetes mellitus. The anti-inflammatory effect of the test product containing recombinant human angiogenin was compared with that of another reference product in a model of adjuvant-induced arthritis. Results: according to the study, the test product based on recombinant human angiogenin exerts higher wound healing effect in treating excision, incision, and burn wounds than the reference product (Solcoseryl gel). Being applied, the test product intensifies tissue repair in chronic wounds in the model of alloxan-induced diabetes. The dissociation of necrotic tissues and the progression towards epithelialisation at wound edges are more rapid. The anti-inflammatory effect of the test product based on recombinant human angiogenin is comparable with that of the reference product (Diclofenac gel). Conclusions: the test product based on recombinant human angiogenin in gel form was found to have pronounced wound healing and anti-inflammatory effects comparable with those of reference products.
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Rahadian Syah, Deby Zulkarnain, and Nofran Putra Pratama. "PENGARUH PEMBERIAN GEL BINAHONG TERHADAP PENYEMBUHAN LUKA SAYAT." MEDIA ILMU KESEHATAN 9, no. 3 (2022): 259–68. http://dx.doi.org/10.30989/mik.v9i3.699.
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Background: Effective wound healing will reduce the costs incurred for treatment. Wound assessment, action and selection of treatment are carried out based on conditions and problems. Today's society prefers to do treatment by utilizing natural resources only on incision wounds given binahong leaves.
 Objective: Produces a binahong gel composition that heals cuts and minimizes infection in the incision.
 Methods: This research is included in inferential quantitative with parametric data. The mean difference test was then performed, followed by a paired t-test.
 Results: Administration of Na CMC On day 10 the mean wound closed was 18.83 cm with a standard deviation of 1.15. The administration of 1% binahong gel obtained an average wound healing area of 19.54 cm with a standard deviation of 0.18. The administration of 5% binahomg gel on the 6th day only showed wound healing with a T test value of 0.004 but on day 8 there was no additional wound closure with an average wound healing area of 6.36. The administration of 7.5% gel was known until the 10th day indicating that there was no wound healing. Giving Povidone iodine is known to be on the 8th day showing wound healing with an average wound healing of 6.65 cm.
 Conclusion: The 1% binahong gel was more effective in accelerating the healing of cuts in rats compared to the 5% and 7.5% binahong gel.
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Shaikh, Tanvir Y., and Santram Lodhi. "Evaluation of Myricetin loaded Nanoemulsion Formulation for the Management of Diabetic Wound Healing in Experimental Animals." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 05 (2023): 597–602. http://dx.doi.org/10.25004/ijpsdr.2023.150507.
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Myricetin is considered a flavonols under the category of flavonoids. According to recent research, myricetin has different curative effects on diabetes, cancer, and the heart. It has been suggested that myricetin is a more potent antioxidant than quercetin. The present study aimed to investigate the wound healing effect of myricetin loaded nanoemulsion (MYCT-NE) gel formulation in diabetic animals. Myricetin-loaded nanoemulsion was converted in nanoemulsion gel using carbopol 934 and evaluated for diabetic wound healing effect against wound contraction measurement, hydroxyproline estimation, protein estimation, antioxidant assay and histopathological study. On day 18th of treatment, the wound contraction of Faster wound healing was observed in the MYCT-NE gel treated groups compared to the control group, as indicated by a shorter epithelialization duration. Increased collagen turnover was shown by increased hydroxyproline levels in MYCT-NE gel-treated tissue, which sped up the healing of treated wounds. MYCT-NE gel possesses effective antioxidant activity by restoration of the superoxide dismutase SOD, GSH and catalase level in the wound tissues after treatment and healing. The observations showed that the original tissue regeneration was found efficiently in the wound treated with MYCT-NE gel and reference group without edema and congestion. The results obtained in the present study were indicated that MYCT-NE gel accelerates cutaneous diabetic wound healing through reducing oxidative status in experimental animals.
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Hu, Zhihan, Jiayi Song, and Mengdi Xie. "Injectable Hydrogel-Loaded Rough Heterostructured Nanoparticles for Multi-Procedural Promotion of Diabetic Wound Healing." Applied and Computational Engineering 130, no. 1 (2025): 68–81. https://doi.org/10.54254/2755-2721/2025.20291.
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Wound healing is a complex, multifaceted biological process broadly divided into four overlapping phases: hemostasis, inflammation, proliferation, and remodeling. Each stage of wound healing is critical to successfully restoring tissue integrity, and disruption or delay in any of these stages can lead to delayed healing. Various existing nanomaterials only promote a single stage. In this study, Au-CuS nanoparticles (Au-CuS NPs) with rough surfaces were formed by using gold nanorods (Au NRs) as templates on which copper sulfide (CuS) was grown and transported in an injectable hydrogel (Au-CuS@Gel). Au-CuS@Gel can accelerate all stages of diabetic wound healing. The rough surface of Au-CuS@Gel and the injectable property of hydrogel can adhere to close the wound and generate reactive oxygen species (ROS) under near infrared (NIR) light to effectively kill bacteria in diabetic wounds. Meanwhile, the rough morphology effectively polarizes macrophages to M2 phenotype and accelerates collagen deposition. Au-CuS@Gel can be programmed to promote all stages of diabetic wound healing. It provides a new paradigm for the healing of the special wounds represented by diabetes.
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Egro, Francesco, Alex Repko, Vidya Narayanaswamy, et al. "Soluble chitosan derivative treats wound infections and promotes wound healing in a novel MRSA-infected porcine partial-thickness burn wound model." PLOS ONE 17, no. 10 (2022): e0274455. http://dx.doi.org/10.1371/journal.pone.0274455.
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Burns are physically debilitating and potentially fatal injuries. The most common etiology of burn wound infections in the US is methicillin-resistant Staphylococcus aureus (MRSA), which is particularly recalcitrant when biofilms form. The current standard of care, silver sulfadiazine (SSD) is effective in reducing bacterial load, but less effective in improving burn wound healing. New treatments that can manage infection while simultaneously improving healing would provide a benefit in the treatment of burns. Porcine models are frequently used as a model for human wound healing but can be expensive due to the need to separate wounds to avoid cross contamination. The porcine model developed in this study offers the capability to study multiple partial thickness burn wound (PTBW) sites on a single animal with minimal crosstalk to study wound healing, infection, and inflammation. The current study evaluates a wound rinse and a wound gel formulated with a non-toxic, polycationic chitosan derivative that is hypothesized to manage infection while also promoting healing, providing a potential alternate to SSD. Studies in vitro and in this PTBW porcine model compare treatment with the chitosan derivative formulations to SSD. The wound rinse and wound gel are observed to disrupt mature MRSA biofilms in vitro and reduce the MRSA load in vivo when compared to that of the standard of care. In vivo data further show increased re-epithelialization and faster healing in burns treated with wound rinse/gel as compared to SSD. Taken together, the data demonstrate the potential of the wound rinse/gel to significantly enhance healing, promote re-epithelialization, and reduce bacterial burden in infected PTBW using an economical porcine model.
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Amalia, Mayta Tazkiya. "Green Betel Leaf Gel (Piper betle) as an Alternative to Perineal Wound Healing in Postpartum Mothers." Archives of The Medicine and Case Reports 4, no. 4 (2023): 423–27. http://dx.doi.org/10.37275/amcr.v4i4.349.
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Perineal wounds are tears that occur when the baby is born either spontaneously or by using a tool or action. Administration of amoxicillin and mefenamic acid as pharmacological treatment is not enough for perineal wound healing. An alternative way to heal perineal wounds is using green betel leaf gel, which has the advantage of cold gel properties, so it can reduce pain. The gel has benefits as an anti-inflammatory, antioxidant, antiseptic, and antibacterial, so it can be used as a perineal wound treatment that can help accelerate perineal wound healing. This study aimed to prove the administration of green betel leaf gel (Piper betle) effect on perineal wound healing in postpartum mothers. This study is a quasy experiment with a pretest and posttest with a control group design. Through the technique of purposive sampling, it was found that 32 respondents were divided into two groups, the control group with clean, dry wound care and the intervention group, which was given green betel leaf gel twice a day for 7 days as measured using the REEDA score. Green betel leaf gel is effective for perineal wound healing on the 7th day compared to dry clean treatment.
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Sari, Yunita, Iwan Purnawan, Dhadhang Wahyu Kurniawan, and Eman Sutrisna. "A Comparative Study of the Effects of Nigella sativa Oil Gel and Aloe Vera Gel on Wound Healing in Diabetic Rats." Journal of Evidence-Based Integrative Medicine 23 (January 1, 2018): 2515690X1877280. http://dx.doi.org/10.1177/2515690x18772804.
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Clinicians and wound care nurses in Indonesia usually use Nigella sativa oil (NSO) gel and aloe vera (AV) gel to treat diabetic ulcers. However, there are no studies directly comparing the effects of NSO and AV gels on wound healing, so it is unknown which of these 2 plants is better at promoting wound healing in diabetic ulcers. If the comparative efficacy between these 2 gels was known, it would be important evidence favoring the clinical use of one or the other product in Indonesia. The aim of this study was to investigate and compare the effectiveness of NSO and AV gels on wound healing in a rat model of diabetic ulcers. This experimental study involved 3 groups: NSO gel, AV gel, and controls. Our study showed that from day 5 onward, necrotic tissue and inflammation decreased in the AV gel group compared with the other groups. The wound areas on days 6 ( P = .020) and 7 ( P = .021) were significantly smaller in the AV gel group than in the NSO gel group. Reepithelialization was also better in the AV gel group than in the other groups. This is the first study to compare the effects of AV and NSO gels on wound healing in diabetic ulcers. Our study indicates that the AV gel is better than the NSO gel. Therefore, it is recommended that clinicians and wound care nurses use AV gel instead of NSO gel for the topical treatment of diabetic ulcers.
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Wijaya, Dina Permata, Herlina Herlina, Najma Annuria Fitri, Mardiyanto Mardiyanto, Mustikasanti Mustikasanti, and Firnando Firnando. "Preparation, Characterization, and Wound Healing Activity of Papaya Leaves Extract on Spray Gel." Majalah Obat Tradisional 25, no. 2 (2020): 103. http://dx.doi.org/10.22146/mot.53690.
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Papaya leaves have been using for wound healing that contains flavonoids, saponins, phenolics, chymopapain, and papain enzymes. The aim of this research were preparation, characterization, and wound healing activity of papaya leaves extract on spray gel. Spray gel was formulated with variation of gelling agent such as carbopol 940, HPMC, gellan gum, and hydroxyethylcellulose. The spray gel were characterizated by organoleptic, pH, stickiness test, viscosity, homogeneity, weight, and wound healing activity in rats. The results showed were all of formula spray gel have brown and homogeneous, pH between 5,947-6,347 within pH range of skin, stickiness test between 1,92-8,12 s, viscosity between 880-1740 cPs. Papaya leaves extract on spray gel has wound healing activity in rats faster than extract and positive control that is 16 days. The wound healing of papaya leaves extract on spray gel exhibited significantly different (p<0,05) than negative control.
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Novrianti, Irma, Sari Wijayanti, and Heriani Heriani. "UJI EFEKTIFITAS SEDIAAN SPRAY GEL EKSTRAK BUNGA KENOP (Gomphrena globosa L) TERHADAP PENYEMBUHAN LUKA BAKAR." Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 6, no. 2 (2021): 46–55. http://dx.doi.org/10.36387/jiis.v7i1.803.
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A burn wound is tissue damage after contacting a heat source. Globe amaranth (Gomphrena globosa) is effective for healing burn wounds. This research analyzes the formula of spray gel pursuant to pharmaceutical requirements and the spray gel’s ability to heal burn wounds. The spray gel preparation was made from 12.5%, 15%, and 20% concentrations of globe amaranth extract. Based on the stability test, the spray gel of globe amaranth preparation is stable in storage The test of the effectiveness of globe amaranth-based gel spray for healing burn wounds was conducted on test animals divided into five groups, i.e., control positive (bioplasenton®), control negative (gel-base), FI (spray gel preparation at a 12.5% concentration of globe amaranth extract), FII (spray gel preparation at a 15% concentration of globe amaranth extract), and FIII (spray gel preparation at a 20% concentration of globe amaranth extract) and induced using an iron plate of diameter 1.5 cm. The results indicated a burn wound healing percentage of 51.33% (P%) on test animals on day 14. On FII, the P% was 62%, and FIII, the P% was 63.33% at p < 0.05. The percentage of burn wound healing on FII and FIII was the same as that on control positive at p > 0.05. To conclude, the spray gel preparation from globe amaranth extracts at 15% and 20% concentrations was effective for healing burn wounds.
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Lokesh, K., and C. Hemanth Mahesh. "To Study the Efficacy of Placental Extract Gel in Chronic Non Healing Foot Ulcer." New Indian Journal of surgery 12, no. 4 (2021): 227–31. http://dx.doi.org/10.21088/nijs.0976.4747.12421.5.
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Wound healing is a complex and regulated process that is critical in maintaining the skin barrier function. The numerous disease processes can affect the events involved in wound healing, resulting in chronic, non-healing wounds. These would subject them to significant discomfort and distress and drain the medical system resources enormously. A chronic wound can be defined as that does not heal in an orderly set of stages and in a predictable amount of time or within three months. They remain in the inflammatory phase for too longand never heal or may take years.3,4 Chronic leg and foot ulcers occur in many adults with diabetes, chronic venous insufficiency, arterial disease, prolonged pressure, or neuropathy.5 Chronic ulcers may last for 12 to 13 months and even recur in 60-70% of cases. They cause loss of function and decreased quality of life and significant morbidity.6,7 These chronic ulcers are predominantly seen in elderly, becoming more prevalent and more difficult to treat and are associated with high treatment costs. So wound care has become essential in these ulcers, and surgical debridement and dressings are the corners stones. Many wound dressings like gauge, films, hydrocolloids, gels, foams etc. were developed to both protect the healing wound from infection and to promote the healing process.1 Placental extract gel is a rich source of various peptides, amino acids, nucleotides, PDRNs and carbohydrates, which are believed to support the healing process.9 Application of placental extract preparation increases collagen synthesis, increases tissue protein, accelerates neoangiogenesis, and epithelialization.10 It has an immunotropic effect and causes the release of Epidermal growth factor, Fibroblast growth factor at the tissue level. It also reduces surrounding tissue inflammation and oedema and reduces microbial burden.11 Its application accelerates healing because of amino acids, nucleotide and vitamins that improve healing.
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Tembhurne, Sachin Vinayak, Mitali Dattatray Dange, Dnyaneshwar Rajendra Bembde, and Ziyaurrahman Ataurrahman. "Nanomaterial based therapeutic approach with bovine colostrums for the skin wound management in experimental model of rats." Acta Scientiarum. Biological Sciences 47 (April 14, 2025): e73946. https://doi.org/10.4025/actascibiolsci.v47i1.73946.
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Effective management of burn wounds is crucial for optimal healing, infection prevention, and pain relief. This study blends Bovine colostrum (BC) with Silver Nanoparticles (AgNPs) to create a specialized gel for burn wound care. The primary objective was to evaluate the efficacy of a gel containing 10% BC-loaded AgNPs in treating burn wounds, including wound healing, pain alleviation, infection prevention, and inflammation reduction. UV spectroscopy and zeta sizer were employed to analyze the AgNPs. An absorption peak at 300–400 nm indicated AgNPs formation, with an average size of 243.9 nm confirmed as nanoparticles. Infrared spectroscopy analysis showed distinct peaks representing carbohydrates, lipids, and proteins in the gel. The 10% AgNPs loaded BC gel accelerated wound healing, outperforming NanoColl by day 20. It also reduced oxidative stress, as evidenced by decreased thiobarbituric acid reactive substances (TBARS) and white blood cell counts (WBC). 10% BC gel demonstrates significant promise for burn wound care, as it effectively accelerates the healing process, provides relief from pain, prevents infections, and reduces inflammation.
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Barkat, Md Abul, Harshita, Faheem Hyder Pottoo, Satya Prakash Singh, and Farhan J. Ahmad. "Therapeutic Intervention of Aloe Gel Containing Nano-Sized and Micron-Sized Silver Sulfadiazine Gel on Second-Degree Burn: A Comparative Study." International Journal of Lower Extremity Wounds 17, no. 3 (2018): 176–83. http://dx.doi.org/10.1177/1534734618791860.
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The current work focuses on the formulation development, optimization, and in vivo assessment of nano-sized silver sulfadiazine ( nSSD) and micron-sized silver sulfadiazine ( mSSD) topical gel composed of Aloe vera gel ( Aloe gel) and Carbopol 940 for the management of second-degree burn wound. The optimized concentration of gel-forming agent (Carbopol 940) was chosen based on best possible consistency and spreadability of the gel. The second-degree burn infliction was developed in the posterior region of rats followed by anesthesia. Afterward, the created wounds were further treated individually by both the gel formulation (1 application daily) for 14 days and observations were recorded. The nSSD gel showed better wound healing and a higher degree of tissue hyperplasia as compared with mSSD gel in rats. In vitro drug release study showed better drug release from nSSD gel (74.25 ± 3.331%) as compared with mSSD gel formulation (61.32 ± 2.112%) after 24 hours. The nSSD and mSSD topical gel-treated rats showed 95.63% and 78.75% wound healing after 14 days, while in the case of control group rats, 48.65% wound contraction was seen after 14 days. Furthermore, the histopathological study revealed that the nSSD gel was more efficient in controlling the wound infection and showed better wound healing as compared with mSSD gel formulation.
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Kim, Da, Ji Jang, Song Jang, and Jungsun Lee. "A Novel Substance P-Based Hydrogel for Increased Wound Healing Efficiency." Molecules 23, no. 9 (2018): 2215. http://dx.doi.org/10.3390/molecules23092215.
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The neuropeptide substance P (SP) is known to stimulate wound healing by regulating the production of relevant cytokines as well as cell proliferation and migration. However, the therapeutic application of SP is limited by its low stability under biological conditions and oxidation during purification, formulation, and storage. To address this problem, we developed a novel formulation of SP as an SP gel, and investigated its wound healing activity both in vitro and in vivo. SP in SP gel was stable at various temperatures for up to 4 weeks. In vitro, SP gel exhibited more potential as a candidate wound-healing agent than SP alone, as evidenced by the observed increases in the proliferation and migration of human epidermal keratinocytes and human dermal fibroblasts. In vivo experiments showed that SP gel treatment enhanced the healing of full-thickness wounds in mice as compared to SP alone. These results demonstrate the benefits of SP gel as a promising topical agent for wound treatment.
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Shannon Payseur, Warren Lesser, Kenneth Gossett, and Manish Shashi. "Treating refractory wounds with necrotic tissue, using wound gel and dietary modifications." Asian Journal of Medical Sciences 14, no. 10 (2023): 138–49. http://dx.doi.org/10.3126/ajms.v14i10.55308.
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Background: A certified hyperbaric and wound care specialist in the South-west US evaluated three patients who presented with refractory wounds containing substantial necrotic tissue. Aims and Objectives: The primary aim/objective of this study was for the investigator to ascertain if the wound gel, in combination with dietary changes and standard hyperbaric oxygen treatment (HBOT) when placed on refractory wounds evidentiary with necrotic tissue, would result in favorable wound healing outcomes. This study’s secondary aim/objective was to determine if this treatment approach could result in avoiding costly and deleterious, life-changing amputations, and/or surgical reconstructions. Materials and Methods: The physician investigator conducted this qualitative method case study during her regular professional medical practice. She selected study subjects based on the exigency of patients’ needs. The three subjects selected met three inclusion criteria. The first inclusion criterion was that the patient had at least one serious refractory wound, which wound did not respond to any previous treatment regimens at any treatment center. The second inclusion criterion was that significant necrotic tissue was evidentiary in the wound(s). The third inclusion criterion was that each patient was facing traumatic surgical intervention – either amputation or excision with reconstruction. The investigator measured wound diameters and tracked the time to wound closure and wound healing. In addition, the investigator noted patient comments during the wound healing. Results: In two cases, patients were scheduled for umbilical reconstruction; in the third, the patient was scheduled for a frontal foot amputation. In 10 weeks, the three patients experienced complete wound healing or substantial wound resolution. Case #2 patient initially only received HBOT at a different wound center and was emergently admitted to the hospital after 2 weeks of HBOT (no dietary alteration or specialized wound gel application). The patient underwent wide excisional debridement with general surgery but received the trifurcated treatment regimen after discharge, resulting in wound healing within 10 weeks. Conclusion: These results warrant further study with more subjects to determine the replicability of findings. If the results are generalizable to this population of patients suffering from advanced refractory wounds and facing limb amputations, the health and quality-of-life benefits for these patients and the prospective cost savings on the U.S. health system could be incalculable.
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Chernane, Halima, Mohamed Sbahi, Assmaa Choukri, Aayah Hammoumi, and Elmehdi Darrag. "Incorporating Preservatives And Additives On Aloe Vera Leaf Gel For Microbiological Stability And Oxidative Resistance During Storage: Wound Healing Assay In Vivo." Annals of Dermatological Science 11, no. 1 (2025): 1–12. https://doi.org/10.52338/aods.2025.4679.
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The therapeutic properties of Aloe vera gel are widely recognized. However, it should be stabilized immediately after extraction to avoid its rapid deterioration upon exposure to environmental conditions. In this study, the fresh gel was stabibized by incorporating benzoic acid (0.1 %), vitamin E (300 ppm) and xanthium gum (0.2 %) as preservatives and additives. Then, we monitored pH change, total antioxidant activity and microbial growth throughout the storage at 4°C and 25°C. At 4°C, the stabilized gel with preservatives showed the best antioxidative stability with maintaining the percentage DPPH inhibition up to 50 % after 30 days of storage Adding benzoic acid on fresh gel as an antimicrobial and maintaining an acidic pH (3.57-3.74) during storage were found to be effective against the development of spoilage micro-organisms. Unlike, the no stabilized gels which showed a microbial contamination with an increase in pH values. Furthermore, the healing effectiveness of the stable gel applied topically one daily to mice’s skin wounds until wound closure was assessed by wound contraction every 2 days. Saline solution and Madécassol® cream are used as negative and positive controls respectively. The stable gel used at both concentration on mice groups showed a significant effect on wound closure rate and the shortened healing process compared to control groups. The wound healing began on the 2th post operative day with an increase in wound contraction from 70 and 75 % to 100 % on the 10th day. Thus, our stabilized gel maintained its wound healing efficacy. Keywords: Aloe vera leaf gel; stabilization; antioxidative stability; microbiological stability; therapeutic efficacy; wound healing.
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Desiyana, Lydia Septa, Muhammad Ali Husni, and Seila Zhafira. "UJI EFEKTIVITAS SEDIAAN GEL FRAKSI ETIL ASETAT DAUN JAMBU BIJI (Psidium guajava Linn) TERHADAP PENYEMBUHAN LUKA TERBUKA PADA MENCIT (Mus musculus)." Jurnal Natural 16, no. 2 (2016): 23–32. http://dx.doi.org/10.24815/jn.v16i2.5017.
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Guava leaf has various benefits, one of them is accelerating the healing process of a wound. This study aims to formulate the ethyl acetate fraction into a gel form and test the effectiveness of gel formulation toward open wounds in 16 male mices (Mus musculus) which made excision 1 cm circular full thickness wound on the back of mice parallel with Os. vetebra. The ethyl acetate fraction of guava leaf has been made into concentrations of 5% and 7% with base gel used as negative control and Bioplacenton as positive control. The evaluation towards ethyl acetate fraction gels showed the gels have green-yellow color, guava odor, homogenous, relevant pH to the skin 6,31-6,51, and spread over 2,8-3 cm (stiff gel). The gels were applied onto the wounds twice a day for about 21 days. The observation was conducted every day towards the scab formation day, scab chipped day, and wound healing day. The data were analyzed statistically using one way ANOVA then continued with Tukey test. The average day for scab formation, scab chipped, and wound healing process, successively are in the negative control i.e. 6,50 ; 13,50 ; 20,25, then positive control of 3,75 ; 11,00 ; 17,25, for gel with 5% concentration, 3,75 ; 9,75 ; 16,50, and gel with 7% concentration, 4,50 ; 12,00 ; 18,25. The statistical result showed that the ethyl acetats fraction could accelerate the scab formation (p0,05) and the open-wound healing (p0,05) in mice than the control negative (p0,05), but not in the scab exfoliation (p0,05). Gel concentration 5% accelerated faster in forming the scab, flaking off the scab, and healing the wound compared with the gel concentration of 7%.
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Tripathi, Ankita, Himani Awasthi, Dan Bahadur Rokaya, Dipti Srivastava, and Vivek Srivastava. "Antimicrobial and Wound Healing Potential of Dietary Flavonoid Naringenin." Natural Products Journal 9, no. 1 (2019): 61–68. http://dx.doi.org/10.2174/2210315508666180802104630.
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Background: Naringenin belongs to the class flavanones, and chemically it is known as 5,7-dihydroxy-2-(4-hydroxyphenyl) chroman-4-one. It is one of the dietary poly-phenolic constituents of the citrus fruits and vegetables. Naringenin possesses excellent antioxidant, antiinflammatory, and antimicrobial activities. These activities promote wound healing activity. Naringenin has been incorporated in the gel base to be applied on the wounded skin. The wound healing property of naringenin gel has not been studied extensively in the literature to date. </P><P> Objective: The present study aims to unveil the wound healing property of naringenin gel formulation on excision and incision model. </P><P> Materials and Methods: 0.5% and 1% naringenin was incorporated in a carbopol gel base formulation and evaluated for physicochemical parameters. Incision and excision wound models were used to study wound contraction, tensile strength, healing index, the period of epithelization and histopathological parameters. Antimicrobial activity was performed using agar plate method. Results: Naringenin (0.5% and 1%) treatment shows a significant increase in the percentage of wound contraction, good healing index and shorter epithelization period. Histopathology of naringenin gel treated wound tissue showed more fibroblasts, less macrophage infiltration, and wellformed collagen fibers as compared to control. In incision wound model, the animals were treated with 0.5% and 1% naringenin gel for nine days and showed a significant increase in the tensile strength. Naringenin exerts antimicrobial activity against fungus and E. coli. Conclusion: The present study explored potent wound healing activity of naringenin gels.
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Wang, Song, Huachao Yang, Zhenrui Tang, Gang Long, and Wen Huang. "Wound Dressing Model of Human Umbilical Cord Mesenchymal Stem Cells-Alginates Complex Promotes Skin Wound Healing by Paracrine Signaling." Stem Cells International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/3269267.
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Purpose. To probe growth characteristics of human umbilical cord mesenchymal stem cells (hUCMSCs) cultured with alginate gel scaffolds, and to explore feasibility of wound dressing model of hUCMSCs-alginates compound.Methods. hUCMSCs were isolated, cultured, and identified in vitro. Then cells were cultivated in 100 mM calcium alginate gel, and the capacity of proliferation and migration and the expression of vascular endothelial growth factors (VEGF) were investigated regularly. Wound dressing model of hUCMSCs-alginate gel mix was transplanted into Balb/c mice skin defects. Wound healing rate and immunohistochemistry were examined.Results. hUCMSCs grew well but with little migration ability in the alginate gel. Compared with control group, a significantly larger cell number and more VEGF expression were shown in the gel group after culturing for 3–6 days (P< 0.05). In addition, a faster skin wound healing rate with more neovascularization was observed in the hUCMSCs-alginate gel group than in control groups at 15th day after surgery (P< 0.05).Conclusion. hUCMSCs can proliferate well and express massive VEGF in calcium alginate gel porous scaffolds. Wound dressing model of hUCMSCs-alginate gel mix can promote wound healing through paracrine signaling.
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Adel Alawadi, Hasanain, Kamyab Andarzbakhsh, Ali Rastegari, Zohreh Mohammadi, Mehdi Aghsami, and Fatemeh Saadatpour. "Chitosan–Aloe Vera Composition Loaded with Zinc Oxide Nanoparticles for Wound Healing: In Vitro and In Vivo Evaluations." IET Nanobiotechnology 2024 (May 15, 2024): 1–9. http://dx.doi.org/10.1049/2024/6024411.
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Global concerns due to the negative impacts of untreatable wounds, as well as the growing population of these patients, emphasize the critical need for advancements in the wound healing materials and techniques. Nanotechnology offers encouraging avenues for improving wound healing process. In this context, nanoparticles (NPs) and certain natural materials, including chitosan (CS) and aloe vera (AV), have demonstrated the potential to promote healing effects. The objective of this investigation is to assess the effect of novel fabricated nanocomposite gel containing CS, AV, and zinc oxide NPs (ZnO NPs) on the wound healing process. The ZnO NPs were synthesized and characterized by X-ray diffraction and electron microscopy. Then, CS/AV gel with different ratios was prepared and loaded with ZnO NPs. The obtained formulations were characterized in vitro based on an antimicrobial study, and the best formulations were used for the animal study to assess their wound healing effects in 21 days. The ZnO NPs were produced with an average 33 nm particle size and exhibited rod shape morphology. Prepared gels were homogenous with good spreadability, and CS/AV/ZnO NPs formulations showed higher antimicrobial effects against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The wound healing findings showed significant wound area reduction in the CS/AV/ZnO NPs group compared to negative control at day 21. Histopathological assessment revealed the advantageous impact of this formulation across various stages of the wound healing process, including collagen deposition (CS/AV/ZnO NPs (2 : 1), 76.6 ± 3.3 compared to negative control, 46.2 ± 3.7) and epitheliogenesis (CS/AV/ZnO NPs (2 : 1), 3 ± 0.9 compared to negative control, 0.8 ± 0.8). CS/AV gel-loaded ZnO NPs showed significant effectiveness in wound healing and would be suggested as a promising formulation in the wound healing process. Further assessments are warranted to ensure the robustness of our findings.
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Thammawithan, Saengrawee, Oranee Srichaiyapol, Pawinee Siritongsuk, et al. "Anisotropic Silver Nanoparticles Gel Exhibits Antibacterial Action and Reduced Scar Formation on Wounds Contaminated with Methicillin-Resistant Staphylococcus pseudintermedius (MRSP) in a Mice Model." Animals 11, no. 12 (2021): 3412. http://dx.doi.org/10.3390/ani11123412.
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Staphylococcus pseudintermedius (S. pseudintermedius) infected wounds can cause seriously delayed wound healing processes in animals. Antimicrobial agents that have antimicrobial and wound healing efficacy have become an essential tool for overcoming this problem. In our previous study, anisotropic AgNPs have been reported to have antimicrobial efficiency against animal and human pathogens, and could be suitable as antimicrobial agents for infected wounds. Here, antimicrobial and wound healing activities of anisotropic AgNPs gels were assessed in vivo. BALB/cAJcl mice wounds were infected by Methicillin-resistant Staphylococcus pseudintermedius (MRSP). Then, antibacterial and wound healing activities were evaluated by bacterial cell count, wound contraction, digital capture, and histology. The results show that anisotropic AgNPs gels could eliminate all bacterial cell infected wounds within 7 days, the same as povidone iodine. Wound healing activity was evaluated by wound contraction (%). The results showed 100% wound contraction in groups treated with anisotropic AgNPs gels within 14 days that was not significantly different from povidone iodine and control gel without AgNPs. However, the digital capture of wounds on day 4 showed that anisotropic AgNPs gel prevented pus formation and reduced scar appearance within 21 days. The histology results exhibit improved collagen fiber alignment that supports scar disappearance. In conclusion, these results indicate that anisotropic AgNPs gels are suitable for treating infected wounds. The gel is effective in eliminating bacteria that supports the natural process of wound repair and also causes reduced scar formation.
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Kordestani, Soheila Salahshoor, Farzaneh Nayeb Habib, Fateme Fayyazbakhsh, and Fahimeh Sadat Mohammadi. "The scar-reducing effect of a novel chitosan gel: an in vivo study." Journal of Wound Care 33, Sup4a (2024): cxi—cxvii. http://dx.doi.org/10.12968/jowc.2024.33.sup4a.cxi.
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Objective: Scar tissue formation, as a normal part of wound healing, initiates in the proliferation phase, continues after the remodelling phase, and may cause an unpleasant appearance or disruption in normal functioning. This study investigated the effects of a topical gel on acute wound healing and reducing scars in a rat model. Method: ChitoScar (ChitoTech Company, Iran), a commercial scar-reducing gel based on chitosan, was analysed for antibacterial and antiviral activity through a quantitative suspension test. Its cytotoxic effect was investigated, and then irritation and delayed-type hypersensitivity tests were carried out on rabbits through direct application of the gel. Furthermore, the effect of the chitosan-based gel on wound healing and scar tissue formation was studied in rats with an acute wound in two groups: the treatment group (topical application of the chitosan-based gel); and the control group (without treatment). Histopathological examination was carried out based on the inflammatory cells, collagen fibre, keratinocytes and fibroblasts. Results: Analysis revealed that the chitosan-based gel had no cytotoxicity and caused no erythema, oedema, local or other systemic adverse response. Wound healing occurred earlier in the treatment group, which was a result of a significant increase in re-epithelialisation, angiogenesis, fibroblast population and collagen fibre thickness (p<0.05). In the treatment group, wounds healed completely after 21 days and scars totally disappeared after 28 days, while in the control group, wound healing remained incomplete with distinct scar tissue. Conclusion: The results demonstrated the positive effect of the chitosan-based gel on the duration and quality of the wound healing process, as well as minimising the scar tissue formation in this in vivo study.
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Zahra, Sadaf, Saba Qayyum, Maira Mansoor, et al. "Comparative Efficacy of Aloe Vera Gel versus Normal Saline in Accelerating Episiotomy Wound Healing: A Randomized Controlled Trial." Journal of Health and Rehabilitation Research 4, no. 2 (2024): 949–56. http://dx.doi.org/10.61919/jhrr.v4i2.976.
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Background: Episiotomy is a common obstetric procedure designed to aid vaginal delivery but often complicates postpartum recovery due to wound-related issues. Traditionally, these wounds are treated with normal saline. Recent studies suggest that aloe vera gel may enhance wound healing more effectively, yet comprehensive local data is lacking. Objective: To compare the efficacy of aloe vera gel with normal saline in promoting episiotomy wound healing by the 10th postoperative day. Methods: This randomized controlled trial included 60 gravid females undergoing normal vaginal delivery with episiotomy, randomly allocated into two groups: one treated with aloe vera gel and the other with normal saline. The primary outcome was wound healing, assessed on the 10th postpartum day using the REEDA score, categorized as complete (score <5), partial (score 5-9), or no healing (score 10-15). Written informed consent was obtained from all participants. Results: Participants had an average age of 27.6 ± 5.2 years. The mean REEDA score on the 10th day postpartum was significantly lower in the aloe vera gel group (1.97 ± 1.22) compared to the normal saline group (3.57 ± 2.05; p = 0.001). The frequency of complete wound healing was 100% in the aloe vera group versus 76.7% in the saline group (p = 0.011). Conclusion: Aloe vera gel significantly outperformed normal saline in healing episiotomy wounds by the 10th postoperative day, suggesting its advantageous use over traditional saline dressings in obstetric practice.
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Poernomo, Hendri, Setiawan, and Yuni Darma Dewi. "Effectiveness Extract Gel of Kemangi Leaves (Ocimum basilicum L.) To The Level of Fibroblast For Incision Wound Healing of Wistar RATS (Rattus norvegicus)." Interdental Jurnal Kedokteran Gigi (IJKG) 21, no. 1 (2025): 1–6. https://doi.org/10.46862/interdental.v21i1.11413.
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Introduction: Wound healing using herbal plants is considered safer than chemical drugs. One of the plants that can be used for wound healing is basil leaves (Ocimum basilicum L.). The purpose of this study was to evaluate the effectiveness of administering basil leaf extract gel on the number of fibroblast cells in the healing process of incision wounds in Wistar rats. Research method: This study used an experimental post-test only control group design using 24 male Wistar rats. The research sample was divided into four groups, namely the negative control group (CMC-Na gel), the group given basil leaf extract gel with concentrations of 70%, 80%, and 90%. In vivo testing was carried out by making an incision wound with a length of 20mm and a subcutaneous depth on the back of the rat. The extract was given twice a day for one week, then decapitation was carried out on the 8th day. Research results: Basil extract gel with concentrations of 70%, 80%, and 90% was effective in healing incision wounds. One Way Anova test showed significant differences between the four groups (ρ<0.05). Conclusion: Basil leaf extract gel with a concentration of 80% is more effective in accelerating wound healing
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Saelan, Saelan, Lalu M. Panji Azali, Wahyu Rizky, and Dewi Suryandari. "The Recovery from Grade II Burns in Test Mice (Mus Musculus Linn) After Using Iodine Leaf Latex Gel (Jatropha Multifida Linn)." International Journal of Public Health Excellence (IJPHE) 4, no. 1 (2024): 139–44. http://dx.doi.org/10.55299/ijphe.v4i1.913.
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Burn injuries are emergencies that pose a severe threat and require immediate action to save lives. The saponins, tannins, alkaloids, and flavonoids in iodine leaf latex gel (Jatropha multifida Linn) are known to speed up the healing process for burn wounds. The research aimed to investigate the effect of iodin leaf latex gel on the recovery of grade II burn wounds in male mice (Mus musculus Linn). The research employed a true-experimental laboratory method with-a-post-test-only control design group at the Kusuma Husada University Laboratory in Surakarta. A total of 24 test mice were manipulated and divided into three groups: the positive control group, the negative control group, and the iodine leaf latex gel group. Burn wounds utilized a 1,5 cm superheated mental surface applied to the backs of the mice for 5-10 seconds to induce burn injuries. The observed parameters included the burn wound area, the percentage of burn wound healing, and the duration of burn wound healing. Data analysis operated One-Way ANOVA. The research revealed that iodine leaf latex gel had a restorative time of 8 days and healing percentage of 30,75%. It was better than the other control groups. The statistical analysis indicated significance (<0,05) in the burn wound recovery percentage. In conclusion, a 6% concentration of iodine leaf latex gel had a more favorable effect on burn wound healing than other control groups.
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Banna, Ahmed Hossni El, Fady Sayed Youssef, Hisham Youssef Elzorba, et al. "Evaluation of the wound healing effect of neomycin-silver nano-composite gel in rats." International Journal of Immunopathology and Pharmacology 36 (January 2022): 039463202211134. http://dx.doi.org/10.1177/03946320221113486.
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Objectives: Both nano silver and neomycin have wound healing properties. Silver nanoparticles have been used as main compounds for therapeutic drug delivery systems against various ailments. The present study aimed to prepare a neomycin silver nano-composite gel easily, rapidly, and cheaply method to improve wound healing. Methods: Forty-five Wistar rats (150–200 g) divided into nine groups: wound untreated, wound fusidic acid treated, wound neomycin treated, three groups with wound and neomycin silver nano-composite gel at 1:1, 1:2, and 1:3 concentrations, respectively, and three groups wound treated silver nano gel at the previous concentrations, respectively. Percentages of wound healing and histopathological examination of the wound area were assessed in all groups. Results: Atomic force microscopy (AFM) and transmission electron microscopy (TEM) images demonstrated the spherical shape of neomycin silver nano-composite gel without aggregation but homogenous dispersion in a gel matrix. Dynamic light scattering (DLS) showed a 4 nm size of nano silver, which agrees with AFM image data analysis but not with TEM image due to the good coating of the gel matrix to silver nanoparticles. Dynamic light scattering Zeta potential was −21 mV, illustrating the high bioactivity of the neomycin silver nano-composite. The groups receiving neomycin silver nano-composite gel showed a significantly higher and dose dependent wound healing compared to other treatment groups. Conclusion: The present work confirmed the potential wound healing activity of neomycin silver nano-composite gel compared to either alone.
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Widowati, Wahyu, Ahmad Faried, Rimonta Febby Gunanegara, et al. "Wound Healing Potent of Lyophilized-Secretome Gel from Human Wharton’s Jelly Mesenchymal Stem Cells." Trends in Sciences 21, no. 10 (2024): 8028. http://dx.doi.org/10.48048/tis.2024.8028.
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Wounds that become infected can lead to serious illness or even death if left untreated. Unfortunately, current wound healing treatments don’t always work well. Achieving optimal wound healing involves the coordination of diverse cellular events facilitated by numerous growth factors, cytokines, and chemokines. One potential solution for addressing the wound healing process is using lyophilized-secretome gel from human Wharton’s Jelly Mesenchymal Stem Cells (hWJMSCs-Sec). This gel, called lyophilized-hWJMSCs-Sec gel (LSG) is created by mixing carbomer gel with hWJMSCs-Sec, then freeze-dry it into a powder to maintain its quality and stability. The quality testing of the topical gel formulation is conducted by measuring. The gel is tested for pH, viscosity, consistency, and its appearance. It’s also tested for antioxidant activity using 2,2-Diphenyl-1-picrylhydrazyl (DPPH), and 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays were employed to identify the antioxidant activities of the lyophilized-gel. Proteins level of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2), Epidermal Growth Factor (EGF), basic Fibroblast Growth Factor (bFGF), Interleukin-6 (IL-6), and IL-4 were also measured with the ELISA method. The LSG has a soft and non-sticky texture with clarity, a pandan-like aroma, and excellent adhesion and spreadability. It contains proteins and antioxidants that help wound healing. The lyophilized-Sec gel contained TIMP-2, EGF, bFGF, IL-6, and IL-4 as well as stronger antioxidant properties compared to un-lyophilized-hWJMSCs-Sec gel, and showed promise as an effective remedy for wound healing. HIGHLIGHTS Assessment of the mechanism of action underlying the wound healing effects of the gel, such as its influence on cellular processes, growth factor release, and antioxidant activity. Investigation of the secretome combination with carbomer gel in providing a convenient application for wound treatment. Preservation of active ingredients in the secretome through lyophilization, ensuring stability and enabling extended storage duration. GRAPHICAL ABSTRACT
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Wahyuningsih, Sri, A. Suparlan Isya Syamsu, Nurhikma Awaluddin, and Riki Andriawan. "Burns Wound Healing Activity of Extract Gel Formula of Lidah Buaya (Aloe vera) and Senggani Leaf (Melastoma polyanthum)." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 7, no. 1 (2021): 10–17. http://dx.doi.org/10.22487/j24428744.2021.v7.i1.15251.
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Aloe vera and senggani leaf can accelerate tissue regeneration, re-epithelialization, fibroblast stimulation, and collagen formation in the skin for burns wound healing. Burns wound can cause damage in the capillaries of the skin, then Aloe vera and senggani leaf were formulated into the gel formula for burns wound healing. The gel has the advantage of high water content; then it will hydrate the epidermis layer, increasing the penetration of the active substances. This study aims to formulate a gel of extract Aloe vera and senggani leaf (Melastoma polyanthum) and to evaluate the burns wound healing activity. The gel was formulated by composition of Aloe vera : senggani leaf with concentrations (0.5%: 1%); (0.5% : 3%); and (0.5% : 5%). Burns wound healing activity was observed by the diameter of the burn wound. The result showed that the gel with a concentration of (0.5%: 5%) gave a significance value of 0.692 (p >0.05) against positive control, then it was the formula that effective for burns wound healing.
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Rahmatia, Diyah Annisa, Krisdiana Wijayanti, and Djamaluddin Ramlan. "Kersen leaf extract gel (Muntingia calabura L.) to Improve the healing of perineal wounds in postpartum mothers." MEDISAINS 20, no. 3 (2022): 87. http://dx.doi.org/10.30595/medisains.v20i3.15597.
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Background: Delivery processes experience 90% perineal rupture—worldwide. Previous research on test animals proved the effect of cherry leaf gel on wound healing can kill microorganisms, increase collagen, and repair wound tissue. However, no research has been found on healing perineal wounds in postpartum mothers using cherry leaf gel, so this research is necessary.Purpose: Making and testing kersen leaf extract gel to improve perineal wound healing for postpartum women.Method: This is a quasi-experiment with a pre-post-test with a control group design. The sample consisted of 26 postpartum women with perineal injuries grade 2, divided into two groups (Intervention and control). The intervention was given a combination of kersen leaf gel 25% with antibiotic 2x1 for seven days, and the control group was only given the antibiotic. Perineal wound healing was assessed using the REEDA score. The data analysis used the Mann-Whitney test.Results: The results showed that the average REEDA score was lower in the intervention group than in the control group on day 3 (5.00±1.155 vs. 5.85±0.801; p=0.038), day 5 (2.31±0.650 vs. 3.23±1.013; p=0.029), and day 7 (0.23±0.439 vs. 1.15±0.987; p=0.039).Conclusion: Kersen leaf extract gel is effective in improving perineal wound healing in postpartum women.
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Sun, Mingliang, Yunfan He, Tao Zhou, Pan Zhang, Jianhua Gao, and Feng Lu. "Adipose Extracellular Matrix/Stromal Vascular Fraction Gel Secretes Angiogenic Factors and Enhances Skin Wound Healing in a Murine Model." BioMed Research International 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/3105780.
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Mesenchymal stem cells are an attractive cell type for cytotherapy in wound healing. The authors recently developed a novel, adipose-tissue-derived, injectable extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) for stem cell therapy. This study was designed to assess the therapeutic effects of ECM/SVF-gel on wound healing and potential mechanisms. ECM/SVF-gel was prepared for use in nude mouse excisional wound healing model. An SVF cell suspension and phosphate-buffered saline injection served as the control. The expression levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and monocyte chemotactic protein-1 (MCP-1) in ECM/SVF-gel were analyzed at different time points. Angiogenesis (tube formation) assays of ECM/SVF-gel extracts were evaluated, and vessels density in skin was determined. The ECM/SVF-gel extract promoted tube formation in vitro and increased the expression of the angiogenic factors VEGF and bFGF compared with those in the control. The expression of the inflammatory chemoattractant MCP-1 was high in ECM/SVF-gel at the early stage and decreased sharply during the late stage of wound healing. The potent angiogenic effects exerted by ECM/SVF-gel may contribute to the improvement of wound healing, and these effects could be related to the enhanced inflammatory response in ECM/SVF-gel during the early stage of wound healing.
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Hanafiah, Olivia Avriyanti, Abidin Trimurni, Syafrudin Ilyas, Marline Nainggolan, and Endang Syamsudin. "Formulation and Evaluation of Binahong Leaves Extract Gel on Wound Healing of the Palatal Mucosa." Journal of Biomimetics, Biomaterials and Biomedical Engineering 48 (November 2020): 85–91. http://dx.doi.org/10.4028/www.scientific.net/jbbbe.48.85.
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Wound healing is a complex and integrated process that requires the collective roles of various cells and tissues of the palatal mucosa. During the proliferation phase, the sum of fibroblasts increases in response to damaged oral tissues. Thus, the number of fibroblast cells in the palatal mucosa is a substantial indicator of wound healing. Binahong leaves possess the potential to accelerate wound healing by stimulating fibroblast proliferation. This study aimed to formulate and evaluate the effect of Binahong leaves extract (BLE) gel on wound healing of the palatal mucosa by investigating the fibroblast cell count in Wistar rats. This experimental study was carried out in several stages which included the collection and processing of fresh Binahong leaves followed by extraction with 70% ethanol using maceration method. The extract was formulated to be a gel product with a concentration of 3%, 5%, and 7%. BLE gel was administered to Wistar rats which were deliberately injured at the palatal mucosa by excision. Wound healing was assessed using hematoxylin-eosin staining and the number of fibroblast cells was counted. The result of fibroblast proliferation was analyzed by One Way ANOVA followed by Bonferroni’s test with a significance level of 95%. There were significant differences in fibroblast cell proliferation between all test groups except between base gel and Aloclair® gel, base gel and BLE gel 7%, Aloclair® gel and BLE gel 7%, BLE gel 3% and BLE gel 5%. Application of BLE gel 3% promotes better wound healing of the palatal mucosa of Wistar rats.
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Andjić, Marijana, Biljana Božin, Nevena Draginić, et al. "Formulation and Evaluation of Helichrysum italicum Essential Oil-Based Topical Formulations for Wound Healing in Diabetic Rats." Pharmaceuticals 14, no. 8 (2021): 813. http://dx.doi.org/10.3390/ph14080813.
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As proper wound management is crucial to reducing morbidity and improving quality of life, this study evaluated for the first time the wound healing potential of H. italicum essential oil (HIEO) prepared in the form of ointment and gel in streptozotocin-induced diabetic wound models in rats. After creating full-thickness cutaneous wounds, forty-eight diabetic rats were divided into six groups: (1) negative control; (2) positive control; (3) ointment base; (4) gel base; (5) 0.5% HIEO ointment (6) 0.5% HIEO gel. Wound healing potential was determined by the percentage of wound contraction, hydroxyproline content, redox status, and histological observation. A significant decrease in the wound size was observed in animals treated with HIEO formulations compared with other groups. The HIEO groups also showed a higher level of total hydroxyproline content, and more pronounced restitution of adnexal structures with only the underlying muscle defect indicating the incision site. Hence, our results legitimate the traditional data of the pro-healing effect of HIEO because HIEO in both formulations such as gel and ointment exhibited the significant wound repairing effect in the incision wound model.
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Subitha, R., P. Senthilkumar, and K. Gobinath. "In vivo wound healing potential of chitosan gel based silver nanoparticles synthesized from Martynia annua." Research Journal of Biotechnology 17, no. 9 (2022): 119–33. http://dx.doi.org/10.25303/1709rjbt1190133.
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A green synthesis of silver nanoparticles (AgNPs) incorporated chitosan gel for wound healing applications was developed using medicinal plant Martynia annua fresh leaves extract. The utilization of various medicinal plant materials for the biosynthesis of nanoparticles is considered a green synthetic technology as it does not require any harmful chemicals. The present study dealt with green synthesized AgNPs from M. annua followed by being incorporating into chitosan gel as a delivery system to evaluate their wound healing potential. Attrition of silver nitrate was used to synthesize silver nanoparticles using aqueous plant extracts. Watersoluble organic (or) phytochemical compounds present in the plant materials are responsible to reduce the silver ions to nano-sized silver nanoparticles. The green synthesized nanoparticles were characterized by UV-visible spectroscopy, FT-IR spectroscopy, particle size, zeta potential and cytotoxicity assay. Based on the result of cytotoxicity assay, AgNPs minimum inhibitory concentration of cytotoxicity was fixed incorporated into chitosan gel. The plain chitosan gel and AgNPs incorporated chitosan gel were used to evaluate the in vivo wound healing activity (excision) in Wister albino rats. After complete wound healing, rate of contraction, period of epithelization, histopathology of skin, antioxidant assays (Lipid Peroxidation (LPO), myeloperoxidase (MPO)), antiinflammatory biomarker study of CycloOxygenase (COX-2) were studied. Silver nanoparticles potentially accelerate the wound healing. The present research suggests that the synergistic combination of silver nanoparticle and chitosan is a promising strategy to address various wounds and has better wound healing capacity.
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Lee, Yen-Hsien, Jung-Jhih Chang, Chiang-Ting Chien, Ming-Chien Yang, and Hsiung-Fei Chien. "Antioxidant Sol-Gel Improves Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats." Experimental Diabetes Research 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/504693.
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We examined the effects of vitamin C in Pluronic F127 on diabetic wound healing. Full-thickness excision skin wounds were made in normal and diabetic Wistar rats to evaluate the effect of saline, saline plus vitamin C (antioxidant sol), Pluronic F127, or Pluronic F127 plus vitamin C (antioxidant sol-gel). The rate of wound contraction, the levels of epidermal and dermal maturation, collagen synthesis, and apoptosis production in the wound tissue were determined.In vitrodata showed that after 6 hours of air exposure, the order of the scavenging abilities for HOCl,H2O2, andO2 -was antioxidant sol-gel > antioxidant saline > Pluronic F127 = saline. After 7 and 14 days of wound injury, the antioxidant sol-gel improved wound healing significantly by accelerated epidermal and dermal maturation, an increase in collagen content, and a decrease in apoptosis formation. However, the wounds of all treatments healed mostly at 3 weeks. Vitamin C in Pluronic F127 hastened cutaneous wound healing by its antioxidant and antiapoptotic mechanisms through a good drug delivery system. This study showed that Pluronic F127 plus vitamin C could potentially be employed as a novel wound-healing enhancer.
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Alsareii, Saeed Ali, Javed Ahmad, Ahmad Umar, et al. "Healing Efficacy of Hesperetin-Containing Chitosan Gel in Burn Wound: Formulation Design and In Vivo Evaluation." Journal of Biomedical Nanotechnology 18, no. 12 (2022): 2877–85. http://dx.doi.org/10.1166/jbn.2022.3501.
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More than 5 million people require medical attention due to burn-related injuries annually. Significant research has been carried out in recent decades to develop approaches to improve the healing of burn wounds. The focus has also been on the development of natural product-based therapeutic remedies for the treatment of burn wounds. This has been done primarily due to multimodal mechanisms exhibited by some promising bioactive molecules of natural origin. Hesperetin is one such molecule that possesses strong anti-inflammatory and antioxidant properties. It is mainly obtained from citrus species. The goal of the current study was to assess how well chitosan gel that contains hesperetin may cure burn wounds. The advantage of using chitosan gel is that it could form a depot at the site and provide a protective therapeutic covering over burn wounds. In the present study, hesperetin-containing chitosan gel was prepared and evaluated for percentage hesperetin content, extrudability, spreadability, and rheological behavior. The preclinical wound healing activity was evaluated using an experimental burn wound model in Wistar rats. The results of the animal experiment showed early and better healing of burn wounds in animals treated with hesperetin-containing chitosan gel. There was 92.79% healing after 14 days of application of hesperetin-containing chitosan gel compared to 69.49% healing observed in the control group. Further, the histopathological evaluation suggested no inflammatory cell infiltration, normal epidermal growth, and normal collagen bundle arrangement in these animals. Overall the results provide proof of concept to establish the wound healing potential of hesperetin-containing chitosan gel against burn wounds.
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Anwer, Md Khalid, Mohammed F. Aldawsari, Muzaffar Iqbal, Bjad K. Almutairy, Gamal A. Soliman, and M. Ali Aboudzadeh. "Diosmin-Loaded Nanoemulsion-Based Gel Formulation: Development, Optimization, Wound Healing and Anti-Inflammatory Studies." Gels 9, no. 2 (2023): 95. http://dx.doi.org/10.3390/gels9020095.
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The wound-healing process is complex and prone to interruption or failure, which can result in the development of chronic wounds that never heal. This can be overcome by seeking prompt medical attention, which will reduce the likelihood of complications and speed up the healing of the cutaneous wound. It has been established that functionalized engineered biomaterials are a possible strategy for starting skin wound care. The purpose of the current study is to develop a diosmin (DSM)-loaded nanoemulsion (NE)-based gel formulation and to investigate its wound healing and anti-inflammatory activity on rats. The DSM-loaded NEs (F1-F17) were developed and optimized with the help of Box–Behnken Design Expert. The DSM-Nes were developed using lauroglycol 90 (LG90®) as oil, Tween-80 as surfactant and transcutol-HP (THP) as co-surfactant. The optimized Nes showed globule size (41 ± 0.07 nm), polydispersity index (PDI) (0.073 ± 0.008) and percentage of entrapment efficiency (%EE) (87 ± 0.81%). This optimized DSM-loaded NEs (F1) was further evaluated and incorporated into 1% carbopol 940 gel. F1-loaded gel was then characterized for drug content, spreadability, in vitro release, wound healing, and anti-inflammatory studies. The developed gel of DSM was found to show significantly better (p < 0.05) wound-healing and anti-inflammatory activity.
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Mankar, Someshwar D., Suhas S. Siddheshwar, Santosh B. Dighe, and Abhay Wani. "NOVEL MANGIFERIN-INFUSED PHYTOSOMAL GEL FOR WOUND HEALING: DEVELOPMENT, CHARACTERIZATION AND IN VIVO ASSESSMENT." INDIAN DRUGS 62, no. 01 (2025): 35–47. https://doi.org/10.53879/id.62.01.14914.
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Wound healing impairment remains a significant healthcare challenge. This study aimed to develop and evaluate a mangiferin-enriched phytosomal gel formulation to enhance wound healing through improved bioavailability and controlled release. The gel was developed using factorial design with varying concentrations of polymers and characterized through spectroscopic, thermal and microscopic analyses. The optimized formulation showed a particle size of 171.2 nm with high stability and drug entrapment of 87.35%. The gel maintained consistent drug release over 10 h, reaching 93.04% release, and remained stable for six months under accelerated conditions. Animal studies demonstrated superior wound healing efficacy, achieving 97.43% wound contraction after 14 days, compared to 48.21% in the control group. The findings indicate that the mangiferin-enriched phytosomal gel offers an effective solution for enhanced wound healing through improved bioavailability and controlled release properties.
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Munir, M., SNH Shah, U. Almas, et al. "An assessment of the wound healing potential of a herbal gel containing an Azadirachta indica leaf extract." Veterinární Medicína 66, No. 3 (2021): 99–109. http://dx.doi.org/10.17221/46/2020-vetmed.
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The objective of this study was to produce a Carbopol 940 based gel formula containing an Azadirachta indica leaf extract and evaluate its wound healing potential. The ethanolic extract was derived from the dried leaves of Azadirachta indica and was subjected to a phytochemical evaluation. Three gel formulations of Carbopol 940 containing an Azadirachta indica extract in three different concentrations, i.e., 1, 2, and 3% w/w were prepared. These gels were evaluated for their physical appearance, stability, antimicrobial activity, extrudability, skin irritability, pH, spreadability, and viscosity. The prepared formulas were stable, greenish and homogeneous. None of them showed irritation to the skin. The spreadability (g.cm/sec), viscosity (cps), and pH of all three formulations was 34.68, 53 270–65 400, and 6–7, respectively. Gel-III exhibited the highest antimicrobial potential against E. coli and P. aeruginosa with a zone of inhibition of 16.2 ± 0.6 mm and 15.6 ± 0.6 mm, respectively. It was revealed from the wound healing studies that the epithelialisation time for the Albino rabbits treated with Gel-III was 23 days. The Albino rabbits treated with Gel-I, Gel-II, a standard gel, and those with the untreated one (control), epithelialised in 27, 25, 26, and 34 days, respectively. A formulation containing 3% w/w extract showed better antimicrobial activity, physicochemical characteristics, and pharmacological parameters than the other formulations. It can be concluded that the wound healing process was faster with the gel formulation containing 3% w/w of the Azadirachta indica extract, proposing that this formulation is a promising candidate for wound healing.
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Salsabila, Nanda Lutfia, Diyah Fatmasari, and Sri Wahyuni. "Effectiveness of Centella Asiatica (Pegagan) Spray Gel on Perineal Wound Healing in Postpartum Women." Indonesian Journal of Global Health Research 7, no. 1 (2024): 69–78. http://dx.doi.org/10.37287/ijghr.v7i1.3960.
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Perineal wounds in postpartum mothers can potentially cause infections. The perineal area exposed to lochia and moisture creates an environment conducive to bacterial growth, thus hindering the wound healing process. Infections of perineal wounds can involve various types of bacteria that naturally colonize the skin and genital mucosa. The application of centella asiatica spray gel is one of the non-pharmacological methods for healing perineal wounds in postpartum mothers. This study aims to determine the effectiveness of applying centella asiatica spray gel 3 times a day with a concentration of 25% for 7 days on perineal wound healing and the growth of Staphylococcus aureus bacteria in postpartum mothers. This is a True Experimental study with a pretest–posttest control group design. Based on the inclusion criteria of second-degree perineal wounds with sutures were selected using random sampling, 17 participants to receive centella asiatica spray gel and 17 participants received standard dry-clean care. The level of wound healing was measured using the REEDA score. The growth of Staphylococcus aureus bacteria was measured using a colony counter. REEDA score data were analyzed using the Friedman and Mann-Whitney tests, while Staphylococcus aureus growth was analyzed using the Wilcoxon and Mann-Whitney tests. Based on the average decrease in REEDA scores by 1.06, the application of centella asiatica spray gel was effective for perineal wound healing (p=0.000). There was a significant difference in the average growth of S.aureus (p=0.040) in perineal wounds of postpartum mothers, with the intervention group showing an average difference of 6.34. The application of centella asiatica spray gel 3 times a day with a concentration of 25% for 7 days was effective for perineal wound healing and reducing Staphylococcus aureus growth in postpartum mothers.
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Zahran, Izal, Murni Mursyid, and Hurria Hurria. "Uji Efek Penyembuhan Luka Sayat pada Kelinci (Oryctolagus cuniculus) Menggunakan Getah Jarak Pagar (Jathropha curcas L.) dalam Bentuk Sediaan Gel." Jurnal Surya Medika 8, no. 3 (2022): 81–85. http://dx.doi.org/10.33084/jsm.v8i3.4502.
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The wound is defined as a breakdown of the epithelial integrity of the skin, which can be caused by sharp or blunt trauma, temperature changes, chemicals, explosions, electric shocks, or animal bites. Jatropha sap (Jatropha cuniculus L.) contains tannins and saponins that can stop bleeding, prevent infection, and play a role in wound healing. This study aims to determine whether the sap of Jatropha (Jatropha curcas L.) in the form of a gel can heal cuts and determine the concentration of jatropha sap in an effective gel formulation in healing cuts in experimental animals. The sap was collected and then formulated into a gel with concentrations of 15%, 20%, and 25%. The results showed that the gel formula with a concentration of 15% Jatropha gum could heal wounds for 18 days, a 20% concentration could heal wounds for 17 days, and a 25% concentration could heal wounds for 14 days. At the same time, the gel base cures for 19 days. From the research, it can be concluded that Jatropha (Jatropha curcas L.) latex in the form of a gel can provide the best healing effect at a concentration of 25% with the fastest wound healing time of 14 days.
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Berbudi, Afiat, Ali Akbar Fadlillah, Merry Afni, and Nur Atik. "Effect of Curcuma longa Crude Extract, Curcumin and Nano Curcumin-based Gel Topical Administration on Excised Skin Wound Healing in Swiss-Webster Mice." Biomedical and Pharmacology Journal 14, no. 02 (2021): 635–41. http://dx.doi.org/10.13005/bpj/2165.
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Patients suffering from skin wounds often have their life heavily affected economically and socially. In general, wound healing consists of four different sequentially and overlapping phases. Interrupting those phases results in extending the healing time. Turmeric (Curcuma longa) is widely used by Indonesians to treat wounds, with curcumin as an active substance, which is proven to have various effects on improving wound healing. Therefore, this study aims to determine how the topical application of turmeric gel on affects the acceleration of wound closure. Analytical laboratory experiments were conducted on 24 male Swiss-Webster mice. Subjects were divided into four groups according to where the excision wounds were made on the back, and observed on days 0, 3, 6, 9, 12, and 15 post wound induction. The wound healing acceleration was observed after 3 (p = 0.0003), 6 (p = 0.0085), and 9 (p = 0.0023) days in C. longa-treated mice compared to the control group. However, there was no significant difference found on days 12 and 15 after wounding. In addition, the area under the curve analysis shows significant difference between the C. longa-treated group compared to the control, but not with the group treated with neither curcumin nor nano curcumin gel. In conclusion, topical application of 3% C. longa extract gel improves excised skin healing.
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Tariq, Muniba, Hafiz Muhammad Tahir, Samima Asad Butt, et al. "Silk derived formulations for accelerated wound healing in diabetic mice." PeerJ 9 (January 8, 2021): e10232. http://dx.doi.org/10.7717/peerj.10232.
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Background The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6 mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis. Results The results indicated that the best biocompatible silk combination was of 5% silk fibroin and 5% Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33 ± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5 ± 0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.
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Tariq, Muniba, Hafiz Muhammad Tahir, Samima Asad Butt, et al. "Silk derived formulations for accelerated wound healing in diabetic mice." PeerJ 9 (January 8, 2021): e10232. http://dx.doi.org/10.7717/peerj.10232.
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Background The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6 mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis. Results The results indicated that the best biocompatible silk combination was of 5% silk fibroin and 5% Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33 ± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5 ± 0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.
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Dewi, I. Dewa Ayu Sudiari, Nurmawati Fatimah, and Sutji Kuswarini. "Effect of Topical Gel Ethanol Extract of Gotu Kola Leaf (Centella Asiatica (L.) Urban) on Wound Healing in a White Male Rat (Rattus Norvegicus) Induced by Streptozotocin." Surabaya Physical Medicine and Rehabilitation Journal 5, no. 2 (2023): 78–83. http://dx.doi.org/10.20473/spmrj.v5i2.47921.
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Background: Diabetes mellitus (DM) can have a number of consequences, one of which is diabetic neuropathy, which can cause sores, notably in patients' feet. Wound therapy with synthetic drugs in diabetes is still not functioning as well as expected. Centella Asiatica (L.) Urban has been demonstrated to promote wound healing through a variety of mechanisms, including collagen synthesis stimulation, fibroblast proliferation stimulation, antiulcer, antibacterial, and antioxidant activity. Pharmaceutical treatments for wound healing are routinely utilized upon the assumption that a moist wound is a gel. Aims: The purpose of this study was to see how a topical gel ethanol extract of gotu kola (Centella Asiatica (L.) Urban) promoted wound healing in streptozotocin (STZ)-induced white male rats (Rattus Norvegicus). Methods: This is an experimental study using twenty white male rats (Rattus Norvegicus) caused by STZ. The rats were placed into four groups, each with five rats. These four groups are the control group, the treatment group P1 (ethanol gel gotu kola leaf at 2.5% concentration), the treatment group P2 (ethanol gel gotu kola leaf at 5% concentration), and the treatment group P3 (ethanol gel gotu kola leaf at 10% concentration). STZ was used to promote blood sugar elevation in the rats. The wound healing rate was estimated by comparing the wound healing rates of each group using macroscopic observation. Result: The findings of this study revealed that extract gel gotu kola leaf concentration applied to the wound on days 4, 7, 11, and 14 has a statistically significant influence on wound healing (p=0.000). Conclusion: Based on the research conducted, it can be concluded that gotu kola extract gel has a significant influence on the rats’ wound healing.
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Aakif, Hashmi Dr. Shivappa N. Nagoba* Atiya Shaikh Akhilesh Limaye Shripal Kolsure Harshada Ghuge. "Review On: Anti-inflammatory Polyherbal Gel for Bacterial Skin Infections." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4696–704. https://doi.org/10.5281/zenodo.15543055.
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Medicinal plant is used ancient India. The study of medicinal plants used in wound healing and skin repairing and properties. The present study was prepared wound healing activity a poly herbal gel formulation. The study also aimed to evaluate the impact of polyherbalism on antimicrobial, antioxidant and anti-inflammatory effect there after ratio of ayurvedic drug was optimize according to treat the wound. Polyherbal gel are tested on organism on suitable complete agar medium in petri dishes, cup. where they are used in plant leaves, bark and route, stem etc. they are used in therapeutic purpose, wound healing, mouth ulcer, stomach ulcer, vaginal discharge, infection, diarrhea, scabies etc. Around 80 % people of India, Used in herbal (Ayurvedic property) Medicine. Ayurvedic medicine are safe not a harmful for a body, ayurvedic doctor play a vital role in our doses. Topical formulation to a fast-healing drug are directly to a site of action polyherbal gel applied to a wound, New skin tissue and grow within a cavity between the linked the particle reducing scaring a gel gradually dissolve however it losses the scaffolding support needed for the tissue to repair fully.
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Palgunadi, Bagus Uda, Asih Rahayu, and Yos Adi Prakoso. "Efficacy of Aloe vera Gel on the Excision Wound Healing in Sprague dawley Rats." Medicra (Journal of Medical Laboratory Science/Technology) 4, no. 1 (2021): 46–49. http://dx.doi.org/10.21070/medicra.v4i1.1432.
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Wound is a pathological processes in all living things. Wound includes the overlapping mechanisms. The failure in wound healing causes infection. This study aimed to analyze the efficacy of Aloe vera gel in excisionwound on the rat’s back. This study used 18 male, Sprague Dawley rats, and they were induced excision wound on the back. The rats were separated into 3 groups, K1 = control, K2 = treated with betadin gel, K3 = treated with Aloe vera gel. The therapy was given twice a day for 7 days. The wound measurement was observed in day 3 and 7. The data were analyzed using SPSS. The result showed that Aloe vera gel potentially promote wound healing through the decrease microscopical condition of wound, re-epithelialization, and deposition of collagen better than in group K1 and K2 (p≤0.05). In conclusion, Aloe vera gel promote excision wound healing in Sprague Dawley rats.
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Bertone, Alicia L., Kenneth E. Sullins, Ted S. Stashak, and Robert W. Norrdin. "Effect of wound location and the use of topical collagen gel on exuberant granulation tissue formation and wound healing in the horse and pony." American Journal of Veterinary Research 46, no. 7 (1985): 1438–44. https://doi.org/10.2460/ajvr.1985.46.07.1438.
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SUMMARY Preformed collagen gel was topically applied to cutaneous wounds of the equine dorsal fetlock (thoracic limb) and metatarsal regions to evaluate the effect on exuberant granulation tissue production and wound healing. In 6 horses and 3 ponies (< 140 cm high at the withers and < 365 kg), 36 standardized cutaneous limb wounds were surgically induced (4 wounds/animal); 18 wounds were treated topically with collagen gel, and 18 wounds were not treated (controls). Collagen gel was initially applied to the wound at 0, 2, or 7 days after wound formation (groups 1, 2, and 3, respectively). Four measurements were regularly made: amount of wound contraction and the size of the granulation bed, epithelial covering, and total wound. Sequential skin and wound biopsies were evaluated histologically to assess wound healing. Using a computer, data were analyzed for differences in the 4 measurements between treated and control wounds, between fetlock wounds and metatarsal wounds, and among groups 1, 2, and 3. Analyses were performed on days 15 and 45 of wound healing and on the final day of healing. A significant difference (P > 0.05) in the production of exuberant granulation tissue, rate of epithelialization, or degree of wound contraction was not detected between the collagen-treated and control wounds. Total healing time and final scar size were similar. Wound healing patterns were significantly different (P < 0.05) in the fetlock wounds and metatarsal wounds. All wounds enlarged up to day 15 with fetlock wounds enlarging significantly more than did the metatarsal wounds. Fetlock wounds had a faster rate of contraction than did the metatarsal wounds at day 45; but, due to their smaller size, metatarsal wounds healed significantly faster than did fetlock wounds. The resulting scar size of fetlock and metatarsal wounds was similar. Metatarsal wounds required more resection of exuberant granulation tissue than did fetlock wounds. Propensity to develop exuberant granulation tissue and the rate of healing were directly correlated to body size of the horse. Larger horses required more frequent resection of the granulating wound bed and healed more slowly, despite the relatively smaller wound size as compared with their larger limb size. Ponies (< 140 cm high at the withers and < 365 kg of body weight) healed faster than horses; wounds of the ponies also healed without exuberant granulation tissue formation. Therefore, ponies are not adequate models of wound healing for horses.
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Wang, Rong, Hairui Gao, Zhen Zhao, et al. "Autologous Platelet-rich Plasma for the Treatment of Nonhealing Perineal Wounds: A Report of Two Cases." Wounds: a compendium of clinical research and practice 35, no. 5 (2023): e169-e172. http://dx.doi.org/10.25270/wnds/22077.
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Introduction. Patients with perineal wounds often encounter difficulty in local wound healing after hemorrhoidectomies. PRP contains a high concentration of platelets and has been used to improve wound healing. Objective. In this case study, PRP was used in the treatment of nonhealing perineal wounds to expedite wound healing. Case Reports. The 2 patients in these cases suffered from perineal wounds that were nonhealing for more than 2 months. After assessment of their physical condition, autologous PRP was used in the treatment of both patients. A total of 150 mL of peripheral blood was collected from each patient to prepare autologous PRP in a completely enclosed environment. For one patient, the PRP product was injected subcutaneously around the wound. The rest of the PRP product was activated into a gel by thrombin and calcium chloride, and the gel was applied to the surface of the wound with dressing changes every 5 days. The other patient was externally treated with autologous PRP gel, and dressing changes were administered after a week. The 2 patients were treated twice with PRP, and both completely recovered within 2 weeks without any other treatment. Conclusion. As an autologous blood-derived product, PRP was safe and showed promising results in perineal wound healing.