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Relevant bibliographies by topics / Wound healing / Dissertations / Theses

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Dissertations / Theses on the topic 'Wound healing'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Honaker, Jeremy Seth. "Predictors of wound healing in lower extremity wounds." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1491492683015683.

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2

Errington, Rachel J. "In vitro wound healing." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357419.

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3

Underdown, Mary Jane. "Antioxidants and Wound Healing." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/honors/65.

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Neutrophils and cytokines present during an inflammatory response produce oxidants, such as reactive oxygen species (ROS) or reactive nitrogen species (RNS). These oxidants act as free radicals, a highly reactive species that steal electrons from nearby molecules to satisfy their valence electron needs. The removal of electrons by free radicals produces damage within the healthy cells of tissue. Antioxidants can be used to reduce this oxidative stress and reestablish the necessary environment for wound healing by donating electrons to the free radicals, sparing the damaging effects oxidatio

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4

Weber, Sonja A. "Electrical Characterisation of Wounds and Stimulation of Wound Healing." Thesis, University of Ulster, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516428.

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5

Head, Cynthia C. "Hormonal regulation of cutaneous wound healing effect of androstenediol on stress-impaired wound healing /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186957947.

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6

Doshi, Anuja. "Topical Phenytoin Effects on Palatal Wound Healing." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563487879484746.

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7

Ou, Jingxing. "Chronic wound state associated with cytoskeletal defects and exacerbated by oxidative stress in Pax6+/- aniridia-related keratopathy." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25200.

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8

Sherratt, Jonathan Adam. "Mathematical models of wound healing." Thesis, University of Oxford, 1991. https://ora.ox.ac.uk/objects/uuid:4e3ea7dd-33c6-4696-a2ec-aa3499c8b3f6.

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The complex mechanisms responsible for mammalian wound healing raise many biological questions that are amenable to theoretical investigation. In the first part of this thesis, we consider the role of mitotic auto-regulation in adult epidermal wound healing. We develop a reaction-diffusion model for the healing process, with parameter values based on biological data. The model solutions compare well with experimental results on the normal healing of circular wounds, and we analyse the solutions in one spatial dimension as travelling waves. We then use the model to perform 'mathematical experim

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9

Loots, Miriam Alfonsa Maria. "Wound healing in diabetic ulcers." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/66897.

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10

McCluskey, Jane T. "Mechanisms of embryonic wound healing." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318851.

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11

Bailey, Matthew John. "Protein changes in wound healing." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427693.

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12

Rippon, Mark Geoffrey. "The physiology of wound healing." Thesis, Manchester Metropolitan University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240980.

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13

McHugh, Jolene. "Sensors for monitoring wound healing." Thesis, Ulster University, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.686440.

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Early identification of infection is imperative in the management of chronic wounds in preventing limb threatening events. There is a clear requirement for the development of in situ sensors that can monitor the healing progress of chronic wounds and identify the early onset of infection, providing the clinician with a more detailed picture of the wound dynamics. A variety of carbon composite materials were employed for use in wound monitoring technologies. The mechanical flexibility of the polyethylene and polycarbonate films are ideal for incorporation within existing dressing materials and

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14

Ramier, James Charles. "Biomechanics of corneal wound healing /." Online version of thesis, 1992. http://hdl.handle.net/1850/10786.

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15

Walters, Kyle D. "Wound healing in Caribbean sponges /." Electronic version (PDF), 2003. http://dl.uncw.edu/etd/2003/waltersk/kylewalters.html.

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16

Kanapathy, M. "Translational studies in wound healing." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1569432/.

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This work explores the role of gap junctional proteins (GJP) in wound healing in two clinical settings: venous disease and epidermal grafting. Chronic wounds and ulcers are common and a feared problem particularly in the elderly, causing pain and disability. Treatment costs are estimated at £2-3 billion to the NHS with a further loss of 2 million workdays per year. Varicose veins are the major contributor to the prevalence of ulcers affecting about 0.3-0.5% of the population at any point of time. The expression of GPJ; connexins 43, 30 and 26 were explored in a cross-sectional study of patient

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17

Cook, Julian. "Mathematical models for dermal wound healing : wound contraction and scar formation /." Thesis, Connect to this title online; UW restricted, 1995. http://hdl.handle.net/1773/6756.

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18

Isotupa, Christine. "PTSD as a social wound, do social wounds require social healing?" Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ51201.pdf.

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19

Gan, Lisha. "Corneal cellular proliferation and wound healing /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4505-5/.

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20

Giannelis, Georgios. "Matrix metalloproteinases in scarless wound healing." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36241.

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Objectives: Wound healing in skin often results in scar formation, whereas wound healing in oral palatal mucosa is fast and rarely results in scarring. Understanding the mechanisms that promote oral scarless wound healing may provide novel approaches to prevent scar formation in skin. The goal of the study was to compare the abundance of the major collagenases MMP-1 and MMP-13 and gelatinases MMP-2 and MMP-9 in normal unwounded oral mucosa and skin and in experimental excisional wounds in skin (healing results to scar formation) and oral mucosa (wounds heal with minimal scar formation) at vari

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21

LeBlanc, Sarah. "CEACAM1 deficiency delays cutaneous wound healing." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66794.

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CEACAM1 (CarcinoEmbryonic Antigen-related Cell Adhesion Molecule 1), is expressed at the surface of new blood vessels of tissues undergoing proliferation. In human tumors, CEACAM1 expression is associated with early stages of angiogenesis. CEACAM1 is a known pro-angiogenic factor, increasing VEGF activity in vivo; however, the role of CEACAM1 in angiogenesis warrants further investigation. Excisional wounds were used as an experimental model, as many of the processes that occur in healing wounds also take place in tumor growth - epithelial hyperproliferation, inflammation, an

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22

Liao, Laura. "Signalling in single cell wound healing." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44784.

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A single cell, such as a frog egg, is able to repair injuries by orchestrating a localized signalling response on the plasma membrane. Proteins called Rho GTPases are recruited to, and form patterns around, the wound site. Patterning allows testable hypotheses to be made about the structure of the signalling network. Here, we extend a Rho GTPase signalling model from Simon et al. (2013) to test how a family of enzymes, protein kinase C (PKC), plays a role in cell repair signalling. Our models let PKCs affect basal Rho GTPase activation and/or inactivation rates, with increasing spatial detail.

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23

Waugh, Helen Victoria. "Mathematical models of diabetic wound healing." Thesis, Heriot-Watt University, 2007. http://hdl.handle.net/10399/99.

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24

Bannon, Pauline. "Activation of macrophages during wound healing." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/activation-of-macrophages-during-wound-healing(28ce7af3-3516-43ed-b0e0-93995691e1ac).html.

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Wound repair is a complex series of events that begins immediately after wounding, and can continue for a number of months to years. Various physiological and mechanical factors may impair the healing response, resulting in a chronic wound, characterised by a sustained inflammatory response. One of the main cells involved in both the inflammatory phase and proliferation phase of wound healing is the macrophage. There are thought to be different activation states which allow the macrophage to be involved in the two different phases of wound healing, namely the classically activated macrophage a

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25

Westgate, Samantha Jane. "Biofilms and chronic equine wound healing." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569171.

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Biofilms in human wounds are considered responsible for the non-healing nature of some chronic wounds. Recent advancements in chronic wound healing have resulted from an increased understanding and awareness of biofilms. These findings led to the hypothesis that bacterial biofilms were also present within the wound bed of non- healing equine wounds and could be responsible for the unexplained retardation of some chronic equine wounds. This study aimed to collect and present information regarding the microbiological composition of equine wounds and to present evidence supporting the presence of

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26

Flegg, Jennifer Anne. "Mathematical modelling of chronic wound healing." Thesis, Queensland University of Technology, 2009. https://eprints.qut.edu.au/40164/1/Jennifer_Flegg_Thesis.pdf.

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Chronicwounds fail to proceed through an orderly process to produce anatomic and functional integrity and are a significant socioeconomic problem. There is much debate about the best way to treat these wounds. In this thesis we review earlier mathematical models of angiogenesis and wound healing. Many of these models assume a chemotactic response of endothelial cells, the primary cell type involved in angiogenesis. Modelling this chemotactic response leads to a system of advection-dominated partial differential equations and we review numerical methods to solve these equations and argue that t

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27

Coutin, Julia Viviana. "Cefazolin Concentration in Surgically Created Wounds Treated with Negative Pressure Wound Therapy Compared to Surgically Created Wounds Treated with Nonadherent Wound Dressings." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/49112.

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Our objective was to compare cefazolin concentrations in biopsied tissue samples collected from surgically created wounds treated with negative pressure wound therapy to those collected from surgically created wounds treated with nonadherent dressings. The study design was a prospective, controlled, experimental study. The animal population included 12 female spayed beagles. We hypothesized there would be a difference between the cefazolin concentrations of wounds treated with negative pressure wound therapy when compared to the cefazolin concentrations of wounds treated with nonadherent d

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28

Shen, Yue. "Plasminogen : a novel inflammatory regulator that promotes wound healing." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-68755.

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The plasminogen activator (PA) system has been shown to be intimately involved in wound healing. However, the role of this system in the initiation and resolution of inflammation during healing process remained to be determined. The aims of this thesis were to investigate the molecular mechanism underlying the interaction between the PA system and the inflammatory system during wound healing and to explore the therapeutic potential of plasminogen in various wound-healing models. The role of plasminogen in the inflammatory phase of the healing process of acute and diabetic wounds was studied fi

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29

Pawar, Harshavardhan Vilasrao. "Development and characterisation of medicated wound dressings for chronic wound healing." Thesis, University of Greenwich, 2013. http://gala.gre.ac.uk/11952/.

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Chronic wounds are difficult to heal and exhibit physiological features including prolonged inflammatory phase, mixed bacterial flora resistance and formation of biofilms, ineffectiveness of topical antimicrobials and high volumes of wound exudate. Polymeric gels of Polyox (POL) and blends of POL with carrageenan (CAR), chitosan (CS), hydroxypropylmethylcellulose (HPMC) and sodium alginate (SA) in different weight ratios were used to prepare films by the solvent casting technique and evaluated using scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), differential scanning calo

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30

Dale, Paul David. "Time heals all wounds? : mathematical models of epithelial and dermal wound healing." Thesis, University of Oxford, 1995. http://ora.ox.ac.uk/objects/uuid:aaa4717f-a115-4a34-bb03-d64ce81841d9.

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The mechanisms responsible for the healing of corneal surface wounds are the subject of biological controversy. In particular, the role and source of the regulatory chemical epidermal growth factor (EGF) is an area of intense debate. In the first part of this thesis, we propose a reaction-diffusion model which focuses on the stimulus for increased mitotic and migratory activity due to secretion of EGF. A detailed numerical study of various possible models, with parameter values based on biological data, reveals that, for realistic healing times, EGF must be released by the underlying layers of

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31

Bolitho, Christine. "Studies of serum albumin in wound healing and endothelial apoptosis." Thesis, The University of Sydney, 2006. http://hdl.handle.net/2123/4712.

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32

Jacobsson, Lena. "Evaluation of Novel Materials for Wound Healing." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16592.

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<p>Rapid wound healing is important to regain the skins protective function after injury. Studies have shown that enamel matrix proteins (EMP) have many desirable effects which may accelerate wound healing [Bosshardt <em>et al.</em> 2008].</p><p> </p><p>Polymers (Polymer A, B and C) were formed into a mat form, with or without incorporated enamel matrix derivative (EMD) (Collaboration partner). The materials may be suitable for wound care and drug delivery systems.</p><p> </p><p>Protein release tests were performed on samples incubated in physiological-like solution using pyrogallol red staini

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33

Koskela, M. (Marjo). "Wound healing and skin in severe sepsis." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526214269.

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Abstract It is a generally accepted dogma that sepsis disturbs skin function and wound healing, but surprisingly there is only remote pathophysiological evidence available behind that presumption. As the skin is the largest defensive barrier, the skin dysfunction in severe sepsis deserves more attention. In this study, the suction blister model was used to create experimental wounds. The study population included 44 patients with severe sepsis and 15 controls. The blister fluid was collected to analyse cytokine profile of the skin. The transepidermal water loss and blood flow from the wound we

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34

Szpalski, Caroline. "Co-morbidities induced vasculogenic impaired wound healing." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209533.

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A. Background<p><p>Skin wound healing (WH) is a dynamic and extremely determinate process of cellular, humoral and molecular mechanisms which begins directly after wounding and can last for years. WH is described as is an intricate process in which the skin (or another organ-tissue) repairs itself after injury. The process of skin WH occurs through the actions of an interplay of cells, growth factors and cytokines leading to wound closure.<p><p>WH occurs in three precisely and highly programmed phases: the inflammatory phase (day 0 to day 7) followed by the proliferative phase or vasculogenic

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35

Atherton, Paul. "The role of ultrasound in wound healing." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-ultrasound-in-wound-healing(94a0808e-f676-4431-a415-582525f24674).html.

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Low Intensity Pulsed Ultrasound (LIPUS) is used clinically to promote wound healing. In vivo studies show that LIPUS is effective in a wide range of tissue types, and in vitro experiments show that multiple cell types respond to LIPUS stimulation. Despite this, there is no unifying mechanism of how LIPUS stimulation is sensed by cells, and it is unknown what the early signalling events are. The LIPUS signal is a mechanical one; therefore I hypothesised that mechanosensitive organelles, called focal adhesions, would be essential for the induction of cellular signalling events in response to thi

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36

Pugazhenthi, Kamali, and n/a. "Melatonin : a new factor in wound healing." University of Otago. Department of Pharmacology & Toxicology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081208.151313.

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Wound healing is a dynamic process that ultimately leads to restoration of tissue integrity and function. The pineal gland hormone melatonin is known for its anti-oncotic, anti- inflammatory and immuno-modulatory effects. However, its role in wound healing has not been established. Since melatonin is synthesised endogenously, we primarily sought to investigate whether the melatonin receptors played a role in the wound healing process. Using immunohistochemical methods and Western blot analysis we observed that MT₁ was normally absent in the rat skin but was strongly expressed on day 1 to day

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37

Tomás, Barberán Santiago. "Inflammation and wound healing following photorefractive keratectomy /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3449-5/.

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38

Lai, Amy M. "Role of aminopeptidase N in wound healing." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/39957.

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The dynamics and complexity of tissue repair are dominated by specific and intricately coordinated cellular events. Disruptions at the level of cellular communication are associated with imbalanced extracellular matrix (ECM) synthesis/degradation leading to fibrosis and chronic wounds. Our group has demonstrated that 14-3-3 sigma (also known as stratifin) functions as a stimulator of matrix metalloproteinase-1 (MMP-1) through interactions with aminopeptidase N (APN) on the surface of dermal fibroblasts. In this doctoral research project, it is hypothesized that APN functions as a receptor for

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39

Zhang, Gaofeng. "Electric signals regulated immunomodulation and wound healing." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/42430/.

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Endogenous electric fields (EFs) are present during a variety of physiologic and pathologic events, including penetrating injury to epithelial barriers. An applied electric field with strength within the physiologic range can induce directional cell migration of epithelial cells, endothelial cells, fibroblasts, and immune cells suggesting a potential role in controlling cell behaviours during wound healing. Dendritic cells (DCs) and dermal fibroblasts were used to explore the molecular mechanisms underlie EF-induced cell activities during two aspects of wound healing: immune response and remod

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40

Sharma, G. U. "Modulation of wound healing after glaucoma surgery." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1527404/.

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Glaucoma is the leading cause of irreversible blindness worldwide. Glaucoma is a progressive eye disorder characterised by atrophy of the optic nerve. In some cases, poor aqueous drainage may cause raised intraocular pressure, which causes damage to the optic nerve, leading to blindness. One of the approaches to lower intraocular pressure is to surgically create a drainage channel for the outflow of aqueous humour. Impaired wound healing and continued scarring response at the site of surgery can lead to suboptimal intraocular pressure control and eventual failure of surgery in many patients. C

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41

Greenhowe, Jennifer. "Stem and progenitor cells in wound healing." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:87a9a7a1-b595-458a-913f-64497174f988.

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As more patients with large body surface area burns are surviving and requiring reconstructive surgery, there is a necessity for advances in the provision of bioengineered alternatives to autologous skin cover. The aims of this Thesis are to identify feasible source tissues of Endothelial Colony Forming Cells and Mesenchymal Stem/Stromal Cells for microvascular network formation in vitro with three-dimensional dermal substitute scaffolds. The working hypothesis is that pre-vascularised dermal scaffolds will result in better quality scarring when used with split thickness skin grafts. Human umb

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42

Corbett, Laura. "Morphogen and epigenetic regulation of wound healing." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2935.

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Events during wound repair are reminiscent of developmental events such as cell migration, redifferentiation and proliferation. Factors controlling these processes in the early embryo may therefore be important regulators in adult wound healing. Fibrosis is a disease of dysregulated wound healing with fibroproliferative disorders accounting for 45% of deaths in developed nations. Despite this, effective antifibrotic therapy is limited. Understanding factors regulating wound repair process will aid identification of potential therapeutic targets. This project first explored how activation of de

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43

Whitmont, Kaley J. "Activated protein C in cutaneous wound healing." Thesis, The University of Sydney, 2010. https://hdl.handle.net/2123/28899.

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The skin is the largest organ in the body and functions primarily to provide a protective barrier against the environment. During wounding, the integrity of the skin is compromised, requiring restoration by the dynamic and interactive processes of normal cutaneous wound healing. This highly orchestrated sequence of events involves Wound healing is a highly orchestrated sequence of events involving controlled angiogenesis, and a complex interaction between keratinocytes within the epidermis and dermal cells such as endothelial cells of dermal blood vessels. Angiogenesis relies on the proliferat

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Hsu, Chiao-Wen Ivy. "Serpina3n accelerates wound closure in a murine model of diabetic wound healing." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50361.

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Chronic, non-healing wounds are a major complication of diabetes and are characterized by chronic inflammation and excessive protease activity. While once thought to function primarily as a pro-apoptotic serine protease, granzyme B (GzmB) can also accumulate in the extracellular matrix during chronic inflammation and cleave extracellular matrix (ECM) proteins that are essential for proper wound healing, including fibronectin. We hypothesized that GzmB contributes to the pathogenesis of impaired diabetic wound healing through excessive degradation of the ECM. In the first part of the thesis, we

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45

Boroumand, Soulmaz. "Investigating the epidermal Notch activation during wound healing and the consequences of prolonged Notch activity during skin wound healing." Thesis, Durham University, 2014. http://etheses.dur.ac.uk/10785/.

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The Notch signaling pathway is critically involved in cell fate decisions during skin development and homeostasis. In the present study an in vivo model (seven-week-old male, C57BL/6) was used to elucidate the role of epidermal Notch activation in the healing of full-thickness dermal wound. Immunolocalization of activated Notch1, Notch2 and Jagged1 was performed during skin wound healing in vivo in mice. The expression level of Notch1, Notch 2 and Jagged1 in the C57BL/6 skin was examined by quantitative PCR (qPCR). This study shows that skin injury rapidly actives Notch signaling in the epider

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Hong, Sung-Ha. "Development of a wound dressing for detection of bacteria with wound healing properties." Thesis, University of Bath, 2013. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619143.

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There has been a significant increase in children’s burns in the past several years and figures indicate that children suffer more burns compared to any other age groups. The main concern following a burn is the possibility of infections. The aim of this project is to construct a unique wound dressing, which enhances healing and stimulates wound closure by incorporation of collagen, as well as signalling the presence of pathogenic bacteria on colonisation. The process of signalling bacterial colonisation was achieved by incorporation of a phospholipid based nanocapsule, with a colourimetric re

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47

Khathide, Bongai. "Assessing modified chitosan wound dressings to enhance wound healing in the porcine model." Thesis, University of Pretoria, 2020. http://hdl.handle.net/2263/75685.

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Dressings enhancing wound healing can improve the outcome of wounds where tissue replacement is required, like for burns and ulcers. Treatment of these wounds is complex due to their depth and excessive tissue loss. Replacement of the lost tissue and delivery of growth factors could enhance healing and reduce scarring. The natural biomaterial; chitosan is reported to bind growth factors, with reduced wound healing times when used in dressings. This study aimed to modify chitosan into a wound dressing filler that would optimise growth factor delivery to full-thickness wounds and overall reduce

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48

Bohling, Mark W. "Cutaneous wound healing in the cat a macroscopic and histologic description and comparison with cutaneous wound healing in the dog /." Auburn, Ala., 2007. http://repo.lib.auburn.edu/2007%20Spring%20Dissertations/BOHLING_MARK_55.pdf.

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49

Karlsson, Lena, and Susanne Asteberg. "Undertrycksbehandling hos diabetiker med fotsår." Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-37785.

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Introduktion: Sjuksköterskor idag står inför en växande patientgrupp med diabetes, som har svårläkta fotsår. Patienterna finns i alla vårdformer som primärvård, specialistvård och kommunal hälso- och sjukvård. För att patienten ska kunna upprätthålla en god livskvalitet och ett bra socialt liv krävs det en säker och snabb sårläkning. Syfte: Arbetets syfte var att beskriva vad som påverkar sårläkning hos patienter med diabetes och svårläkt fotsår, vid undertrycksbehandling. Metod: Denna litteraturstudie har utgått ifrån Polit och Becks (2012) niostegsmodell. Sökningarna har gjorts i CINAHL och

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50

Öhnstedt, Emelie. "Accelerated wound healing by on-site production and delivery of CXCL12." Licentiate thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-442088.

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Non-healing wounds is a growing medical problem, often associated with pathological conditions such as diabetes and peripheral ischemia. A non-healing wound entails a large amount of suffering for the patient, and demands extensive health care resources. In this thesis, a new drug treatment paradigm for wound healing was developed by transforming Limosilactobacillus reuteri R2LC with a plasmid encoding CXCL12 (LB_CXCL12). The drug candidate was tested for safety and biological effects following topical administration to full thickness wounds in both mice and minipigs. In parallel, different te

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