Academic literature on the topic 'Www.sub.uni-goettingen.de'

Zusammenfassung Im Rahmen eines vom Niedersächsischen Ministerium für Wissenschaft und Kultur (MWK) geförderten Restaurierungsprojekts werden an der Niedersächsischen Staats- und Universitätsbibliothek Göttingen in der Zeit von September 2017 bis einschließlich Februar 2018 für zwei Teilsammlungen aus dem Fragmentebestand der Abteilung Spezialsammlungen und Bestandserhaltung Dokumentations- und Restaurierungsmaßnahmen durchgeführt.https://www.sub.uni-goettingen.de/projekte-forschung/projektdetails/projekt/restaurierung-von-5300-mittelalterlichen-und-fruehneuzeitlichen-handschriftenfragmenten/ [Zugriff: 12.02.2018]. Durch die Restaurierung wird die langfristige Aufbewahrung sichergestellt und sowohl die spätere Digitalisierung als auch die analoge Nutzung ermöglicht. Gleichzeitig können wertvolle Informationen zur Sammlungsgeschichte gewonnen werden, von denen weitere laufende Erschließungsprojekte der SUB Göttingen profitieren können.

Bacillus subtilis is the model organism for a large group of Gram-positive bacteria, the Firmicutes. Several online databases have been established over time to manage its genetic and metabolic information, but they differ greatly in their rate of update and their focus on B. subtilis. Therefore, a European systems biology consortium called for an integrated solution that empowers its users to enrich online content. To meet this goal we created SubtiWiki and SubtiPathways, two complementary online tools for gene and pathway information on B. subtilis 168. SubtiWiki (http://subtiwiki.uni-goettingen.de/) is a scientific wiki for all genes of B. subtilis and their protein or RNA products. Each gene page contains a summary of the most important information; sections on the gene, its product and expression; sections concerning biological materials and laboratories; and a list of references. SubtiWiki has been seeded with key content and can be extended by any researcher after a simple registration, thus keeping it always up to date. As a complement, SubtiPathways (http://subtipathways.uni-goettingen.de/) is an online tool for navigation of the metabolism of B. subtilis and its regulation. Each SubtiPathways diagram presents a metabolic pathway with its participating enzymes, together with the regulatory mechanisms that act on their expression and activity, in an intuitive interface that is based on Google Maps. Together, SubtiWiki and SubtiPathways provide an integrated view of the processes that make up B. subtilis and its components, making it the most comprehensive web resource for B. subtilis researchers.

Background The concept of chromatin domains attached to the nuclear matrix is being revisited, with nucleus described as a set of topologically associating domains. The significance of the tightly bound to DNA proteins (TBP), a protein group that remains attached to DNA after its deproteinization should be also revisited, as the existence of these interactions is in good agreement with the concept of the topologically associating domain. The work aimed to characterize the DNA component of TBP isolated from barley seedlings. Methods The tight DNA-protein complexes from the first leaves, coleoptiles, and roots of barley seedlings were isolated by purification with chromatography on nitrocellulose or exhaustive digestion of DNA with DNase I. Cloning and transformation were performed using pMOSBBlue Blunt Ended Cloning Kit. Inserts were amplified by PCR, and sequencing was performed on the MegaBace 1000 Sequencing System. The BLAST search was performed using sequence databases at NCBI, CR-EST, and TREP and Ensembl Plants databases. Comparison to MAR/SAR sequences was performed using http://smartdb.bioinf.med.uni-goettingen.de/cgi-bin/SMARtDB/smar.cgi database. The prediction of G quadruplexes (GQ) was performed with the aid of R-studio library pqsfinder. CD spectra were recorded on a Chirascan CS/3D spectrometer. Results Although the barley genome is AT-rich (43% of GC pairs), most DNA fragments associated with TBP were GC-rich (up to 70% in some fractions). Both fractionation procedures yielded a high proportion of CT-motif sequences presented predominantly by the 16-bp CC(TCTCCC)2 TC fragment present in clones derived from the TBP-bound DNA and absent in free DNA. BLAST analysis revealed alignment with different barley repeats. Some clones, however, aligned with both nuclear and chloroplast structural genes. Alignments with MAR/SAR motifs were very few. The analysis produced by the pqsfinder program revealed numerous potential quadruplex-forming sites in the TBP-bound sequences. A set of oligonucleotides containing sites of possible GQs were designed and ordered. Three of them represented the minus strand of the CT-repeat. Two were derived from sequences of two clones of nitrocellulose retained fraction from leaves and contained GC-rich motifs different from the CT motif. Circular dichroism spectroscopy revealed profound changes in spectra when oligonucleotides were incubated with 100 mM KCl. There was either an increase of positive band in the area of 260 nm or the formation of a positive band at 290 nm. In the former case, changes are typical for parallel G-quadruplexes and, in the latter, 3 + 1 structures. Discussion The G-quadruplexes anchor proteins are probably involved in the maintenance of the topologically associated domain structure.

Abstract Background Conformational transitions are implicated in the biological function of many proteins. Structural changes in proteins can be described approximately as the relative movement of rigid domains against each other. Despite previous efforts, there is a need to develop new domain segmentation algorithms that are capable of analysing the entire structure database efficiently and do not require the choice of protein-dependent tuning parameters such as the number of rigid domains. Results We develop a graph-based method for detecting rigid domains in proteins. Structural information from multiple conformational states is represented by a graph whose nodes correspond to amino acids. Graph clustering algorithms allow us to reduce the graph and run the Viterbi algorithm on the associated line graph to obtain a segmentation of the input structures into rigid domains. In contrast to many alternative methods, our approach does not require knowledge about the number of rigid domains. Moreover, we identified default values for the algorithmic parameters that are suitable for a large number of conformational ensembles. We test our algorithm on examples from the DynDom database and illustrate our method on various challenging systems whose structural transitions have been studied extensively. Conclusions The results strongly suggest that our graph-based algorithm forms a novel framework to characterize structural transitions in proteins via detecting their rigid domains. The web server is available at http://azifi.tz.agrar.uni-goettingen.de/webservice/.

Gerd Althoff, „Selig sind, die Verfolgung ausüben“. Päpste und Gewalt im Hochmittelalter. Stuttgart, Konrad Theiss Verlag 2013, 254 S. (Wendelin Knoch: Hattingen, E-Mail: wendelin.knoch@ruhr-uni-bochum.de) Günter Bayerl, Technik in Mittelalter und Früher Neuzeit. Stuttgart, Konrad Theiss Verlag GmbH 2013. 199 S. 101 Abb. (Christian Scholl: Münster, E-Mail: christian.scholl@uni-muenster.de) Andrea Beck/Andreas Berndt (Hgg.), Sakralität und Sakralisierung. Perspektiven des Heiligen (Beiträge zur Hagiographie 13). Stuttgart, Franz Steiner 2013. 210 S. (Peter Gemeinhardt: Göttingen, E-Mail: Peter.Gemeinhardt@theologie.uni-goettingen.de) Jochen Bepler/Christian Heitzmann (Hgg.), Der Albani-Psalter. Stand und Perspektiven der Forschung. Hildesheim, Olms 2013. 230 S. (Gia Toussaint: Hamburg, E-Mail: gia.toussaint@uni-hamburg.de) Andreas Bihrer, Begegnungen zwischen dem ostfränkisch-deutschen Reich und England (850–1100). Kontakte – Konstellationen – Funktionalisierungen – Wirkungen (Mittelalter-Forschungen 39). Stuttgart, Thorbecke 2012. 668 S. (Sören Kaschke: Köln, E-Mail: soeren.kaschke@uni-koeln.de) Anna-Maria Blank/Vera Isaiasz/Nadine Lehmann (Hgg.), BILD – MACHT – UnORDNUNG. Visuelle Repräsentationen zwischen Stabilität und Konflikt (Eigene und Fremde Welten 24). Frankfurt am Main, Campus 2011. 317 S. (Anja Rathmann-Lutz: Basel, E-Mail: anja.lutz@unibas.ch) Karl-Heinz Braun, Mathias Herweg, Hans W. Hubert, Joachim Schneider u. Thomas Hotz (Hgg.), Das Konstanzer Konzil. Essays. Darmstadt, Wissenschaftliche Buchgesellschaft 2013. 248 S. 60. (Thomas Woelki: Berlin, E-Mail: woelkith@geschichte.hu-berlin.de) Erhard Brepohl, Theophilus Presbyter und das mittelalterliche Kunsthandwerk. Gesamtausgabe der Schrift ‚De diversis artibus‘ in einem Band, 2. Aufl. Köln/Weimar/Wien, Böhlau 2013. 511 S. (Ingrid Baumgärtner: Kassel, E-Mail: ibaum@uni-kassel.de) Andrea Denke, Konrad Grünembergs Pilgerreise ins Heilige Land 1486. Untersuchung, Edition und Kommentar (Stuttgarter Historische Forschungen, Bd. 11). Köln/Weimar/Wien, Böhlau Verlag 2011. 587 S. (Ekkehart Rotter: Bad Vilbel, E-Mail: mail@ekkehart-rotter.de) Gerhard Fouquet/Gabriel Zeilinger, Katastrophen im Spätmittelalter. Darmstadt/Mainz, Philipp von Zabern 2011. 172 S. (Stefanie Dick: Kassel, E-Mail: stefanie.dick@uni-kassel.de) Johannes Fried, Karl der Große. Gewalt und Glaube. Eine Biographie. München, C. H. Beck 2013. 736 S. (Michael Dallapiazza: Prato-Urbino, E-Mail: m.dallapiazza@uniurb.it) Hans-Werner Goetz, Gott und die Welt. Religiöse Vorstellungen des frühen und hohen Mittelalters. Teil I, Bd. 2: II. Die materielle Schöpfung: Kosmos und Welt, III. Die Welt als Heilsgeschehen (Orbis mediaevalis 13.2). Berlin, Akademie Verlag 2012. 320 S. (Thomas Vogtherr: Osnabrück, E-Mail: Thomas.Vogtherr@uni-osnabrueck.de) Martina/Wilfried Hartmann, Karl der Große und seine Zeit. Die 101 wichtigsten Fragen. München, C. H. Beck 2014, 160 S. (Klaus Oschema: Heidelberg, E-Mail: klaus.oschema@zegk.uni-heidelberg.de) Bernd-Ulrich Hergemöller, Uplop – Seditio: Innerstädtische Unruhen des 14. und 15. Jahrhunderts im engeren Reichsgebiet. Schematisierte vergleichende Konfliktanalyse (Studien zur Geschichtsforschung des Mittelalters 128). Hamburg, Dr. Kovač 2012, 293 S. (Michael Hecht: Münster, E-Mail: michael.hecht@uni-muenster.de) Charlotte Klack-Eitzen, Wiebke Haase u. Tanja Weißgraf, Heilige Röcke. Kleider für Skulpturen im Kloster Wienhausen. Regensburg, Schnell und Steiner 2013. 184 S. (Gia Toussaint: Hamburg, E-Mail: gia.toussaint@uni-hamburg.de) Florian Kragl, Heldenzeit. Interpretationen zur Dietrichepik des 13. bis 16. Jahrhunderts. Heidelberg, Universitätsverlag Winter 2013. 593 S. (Michael Dallapiazza: Prato-Urbino, E-Mail: michael.dallapiazza@uniurb.it) Andreas Külzer, Byzanz. Stuttgart, Theiss 2012. 177 S. – Reinhard Pohanka, Das byzantinische Reich. Wiesbaden, Marixverlag 2013. 191 S. (Michael Grünbart: Münster, E-Mail: gruenbart@uni-muenster.de) Ralph W. Mathisen/Danuta Shanzer (Hgg.), The Battle of Vouille, 507 CE: Where France Began (Millennium-Studien 37). Boston/Berlin, De Gruyter 2012. XXVI, 216 S. (Guido M. Berndt: Erlangen-Nürnberg, E-Mail: guido.berndt@fau.de) The Medieval Legends of Philosophers and Scholars (Micrologus XXI). Firenze, SISMEL – Edizioni del Galluzzo 2013. 634 S.­­ (Henryk Anzulewicz: Bonn, E-Mail: anzulewicz@albertus-magnus-institut.de) Wolfgang Metternich, Teufel, Geister und Dämonen. Das Unheimliche in der Kunst des Mittelalters. Darmstadt, Wissenschaftliche Buchgesellschaft 2011. 144 S. (Angelica Rieger: Aachen, E-Mail: mail@angelica-rieger.de) Cordula Nolte (Hg.), Phänomene der „Behinderung“ im Alltag. Bausteine zu einer Disability History der Vormoderne (Studien und Texte zur Geistes- und Sozialgeschichte des Mittelalters 8). Affalterbach, Didymos-Verlag 2013. 368 S. (Hans-Werner Goetz: Hamburg, E-Mail: Hans-Werner.Goetz@uni-hamburg.de) Irven M. Resnick (Hg.), A Companion to Albert the Great. Theology, Philosophy, and the Sciences (Brill’s Companions to the Christian Tradition 38). Leiden, Brill 2013. 833 S. (Jörg Alejandro Tellkamp: Mexiko-Stadt, E-Mail: tlkp@xanum.uam.mx) Janina M. Safran, Defining Boundaries in al-Andalus. Muslims, Christians, and Jews in Islamic Iberia. Ithaca NY, Cornell University Press 2013. 272 S. (Christian Saßenscheidt: Erlangen, E-Mail: christian.sassenscheidt@gesch.phil.uni-erlangen.de) Barbara Stollberg-Rilinger/Thomas Weissbrich (Hgg.), Die Bildlichkeit symbolischer Akte. Symbolische Kommunikation und gesellschaftliche Wertesysteme (Schriftenreihe des Sonderforschungsbereichs 496 Bd. 28). Münster, Rhema 2010. 411 S. (Vera v. der Osten-Sacken: Berlin, E-Mail: ostensav@hu-berlin.de) Roland Zingg, Die Briefsammlungen der Erzbischöfe von Canterbury 1070–1170. Kommunikation und Argumentation im Zeitalter der Investiturkonflikte (Zürcher Beiträge zur Geschichtswissenschaft 1). Köln/Weimar/Wien, Böhlau Verlag 2012. 343 S. (Georg Strack: München, E-Mail: georg.strack@lmu.de)