Relevant bibliographies by topics / Xanthine oxidase inhibitors

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Xanthine oxidase inhibitors'

Author: Grafiati
Published: 5 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "Xanthine oxidase inhibitors"

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Kapoor, N., S. Saxena, and L. Gambhir. "FUNGAL ENDOPHYTES AS REPOSITORY OF XANTHINE OXIDASE INHIBITOR." INDIAN DRUGS 56, no. 03 (2019): 7–11. http://dx.doi.org/10.53879/id.56.03.11371.

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Xanthine oxidase, a key enzyme of purine metabolism, is considered to be a prime target for the treatment of hyperuricemia and oxidative stress related disorders. Allopurinol and febuxostat are two FDA approved xanthine oxidase inhibitors currently being used for management of chronic hyperuricemia. Plethora of natural sources has been explored in search of novel chemical templates for the development of antihyperuricemic drugs. Studies in past decade have shown the potential of endophytic fungi, which colonize the internal tissues of plants without any evident sign of their ubiquitous existen
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Malik, Neelam, Anurag Khatkar, and Priyanka Dhiman. "Computational Analysis and Synthesis of Syringic Acid Derivatives as Xanthine Oxidase Inhibitors." Medicinal Chemistry 16, no. 5 (2020): 643–53. http://dx.doi.org/10.2174/1573406415666191004134346.

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Background: Xanthine oxidase (XO; EC 1.17.3.2) has been considered as a potent drug target for the cure and management of pathological conditions prevailing due to high levels of uric acid in the bloodstream. The role of xanthine oxidase has been well established in the generation of hyperuricemia and gout due to its important role in catalytic oxidative hydroxylation of hypoxanthine to xanthine and further catalyses of xanthine to generate uric acid. In this research, syringic acid, a bioactive phenolic acid was explored to determine the capability of itself and its derivatives to inhibit xan
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Dhammaraj, Taweesak, Phoobet Kotseekieo, Tunnathon Chotikarn, et al. " In vitro investigation of xanthine oxidase inhibitory and antioxidant activities of 3,4,5-trihydroxycinnamic acid." Journal of Herbmed Pharmacology 13, no. 3 (2024): 439–49. https://doi.org/10.34172/jhp.2024.49420.

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Introduction: Xanthine oxidase inhibitors with strong antioxidant activity are promising candidates for the treatment of gout and reactive oxygen species (ROS)-related disorders. 3,4,5-Trihydroxycinnamic acid (THCA), a natural hydroxycinnamic acid, exhibits strong antioxidant activities. This study investigated its xanthine oxidase inhibitory and antioxidant activities in comparison with sinapic acid, caffeic acid, and allopurinol. Methods: In vitro xanthine oxidase inhibitory assay and a Lineweaver-Burk plot were used to measure enzyme inhibition activity and pattern. A docking study was used
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Arora, Tripti, and Ketki Rani. "Docking Studies of Potent Xanthine Oxidase Inhibitors-Molecules Patented and Published from 2011-2020." Oriental Journal Of Chemistry 38, no. 4 (2022): 875–83. http://dx.doi.org/10.13005/ojc/380406.

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Hyperuricemia is characterized by elevated serum uric (SUA) levels beyond 6.8mg/dl and is a major cause of gout. Clinically, the high uric acid levels are managed using oral xanthine oxidase inhibitors such as febuxostat; however, its long-term use affects liver functions and cannot be used with the person with compromised liver functions. Thus, searching for an alternate xanthine oxidase inhibitor devoid of side effects on the liver is of current interest. Several classes of XO inhibitors have been patented in recent years. Using a docking study, we investigated the binding mode of xanthine o
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Mohos, Violetta, Attila Pánovics, Eszter Fliszár-Nyúl, et al. "Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme." International Journal of Molecular Sciences 20, no. 11 (2019): 2681. http://dx.doi.org/10.3390/ijms20112681.

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Quercetin is an abundant flavonoid in nature and is used in several dietary supplements. Although quercetin is extensively metabolized by human enzymes and the colonic microflora, we have only few data regarding the pharmacokinetic interactions of its metabolites. Therefore, we investigated the interaction of human and microbial metabolites of quercetin with the xanthine oxidase enzyme. Inhibitory effects of five conjugates and 23 microbial metabolites were examined with 6-mercaptopurine and xanthine substrates (both at 5 μM), employing allopurinol as a positive control. Quercetin-3′-sulfate,
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Diniatik, Diniatik, Suwijiyo Pramono, and Sugeng Riyanto. "IN SILICO ANALYSIS OF XANTHINE OXIDASE INHIBITOR OF ETHYL ACETATE FRACTION OF ETHANOLIC EXTRACT OF STELECHOCARPUS BURAHOL (BL.) HOOK F. AND TH. LEAVES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 5 (2017): 112. http://dx.doi.org/10.22159/ajpcr.2017.v10i5.15970.

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Objective: The research was conducted by in silico analysis of xanthine oxidase inhibitors of volatile compounds from ethyl acetate fraction of ethanolic extract of Stelechocarpus burahol (Bl.) Hook f. and Th. leaves. The objective of the research was to determine the active compounds as a potential inhibitor of xanthine oxidase by using in silico screening method.Methods: The research was conducted using volatile compounds that were obtained by using gas chromatography of ethyl acetate fraction of ethanolic extract of S. burahol leaves and models of xanthine oxidase inhibitor downloaded via P
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Ansari, Sarah S., Patricia H. Diño, Agnes L. Castillo, and Librado A. Santiago. "Antioxidant activity, xanthine oxidase inhibition and acute oral toxicity of Dillenia philippinensis Rolfe (Dilleniaceae) leaf extract." Journal of Pharmacy & Pharmacognosy Research 9, no. 6 (2021): 846–58. http://dx.doi.org/10.56499/jppres21.1106_9.6.846.

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Context: Hyperuricemia is a metabolic syndrome characterized by a high serum uric acid level with an increased risk of gout, diabetes, cardiovascular and renal disease. Allopurinol is a widely known xanthine oxidase inhibitor that lowers serum uric acid production. Documented adverse effects of the drug raise the need for a natural alternative for xanthine oxidase inhibitor that is safe and effective. This research is driven to address the need by capitalizing on previous studies made on the Dillenia species showing nephroprotective and antihyperuricemic activity. Aims: To evaluate the antioxi
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Dong, Chao, Milka Montes, and Wael M. Al-Sawai. "Xanthine oxidoreductase inhibition – A review of computational aspect." Journal of Theoretical and Computational Chemistry 19, no. 04 (2020): 2040008. http://dx.doi.org/10.1142/s0219633620400088.

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Xanthine Oxidoreductase (XOR) exists in a variety of organisms from bacteria to humans and catalyzes the oxidation of hypoxanthine to xanthine and from xanthine to uric acid. Excessive uric acid could lead to gout and hyperuricemia. In this paper, we have reviewed the recent computational studies on xanthine oxidase inhibition. Computational methods, such as molecular dynamics (molecular mechanics), quantum mechanics, and quantum mechanics/molecular mechanics (QM/MM), have been employed to investigate the binding affinity of xanthine oxidase with synthesized and isolated nature inhibitors. The
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Rui, Guo, Zhang-Yi Qin, Ya-Qing Chang, et al. "Chemical Comparison and Identification of Xanthine Oxidase Inhibitors of Dioscoreae Hypoglaucae Rhizoma and Dioscoreae Spongiosae Rhizoma by Chemometric Analysis and Spectrum–Effect Relationship." Molecules 28, no. 24 (2023): 8116. http://dx.doi.org/10.3390/molecules28248116.

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Dioscoreae hypoglaucae Rhizoma (DH) and Dioscoreae spongiosae Rhizoma (DS) are two similar Chinese herbal medicines derived from the Dioscorea family. DH and DS have been used as medicines in China and other Asian countries for a long time, but study on their phytochemicals and bioactive composition is limited. This present study aimed to compare the chemical compositions of DH and DS, and explore the anti-xanthine oxidase components based on chemometric analysis and spectrum–effect relationship. Firstly, an HPLC method was used to establish the chemical fingerprints of DH and DS samples, and
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Irum, Zoobia, Amer Hassan Siddiqui, Fariha Ahmad Khan, Fouzia Perveen, Asia Firdous, and Neelofer Yousaf. "Xanthine Oxidase Inhibitory Activity of Ethanolic Extract of Ficus Carica Fruit." Pakistan Journal of Medical and Health Sciences 17, no. 1 (2023): 304–6. http://dx.doi.org/10.53350/pjmhs2023171304.

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Hyperuricemia is a purine metabolism disorder characterised by an excess of uric acid in the blood and considered as a risk factor for gout, coronary heart disease, hypertension, diabetes, and a variety of other illnesses. Xanthine oxidase inhibitors have key role in management of hyperuricemia and related disorders but multiple adverse effects associated with these agents have minimized their chronic use. Ficus carica fruit has been widely used around world as a therapeutic agent for several disorders. In traditional medicine it has been used to treat gouty arthritis but the effect has not be
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Dissertations / Theses on the topic "Xanthine oxidase inhibitors"

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Leigh, Maria. "Non purine inhibitors of xanthine oxidase." Thesis, University of York, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550273.

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The increase in the occurrence of hyperuricemia and gout in recent years, coupled with side- effects associated with use of the main anti-gout therapeutic, allopurinol, have triggered the search for non-purine alternatives. The first such inhibitor to be made available is Adenurlc", 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid. The aim of this work was to synthesise a small library of non-purine compounds and evaluate their inhibitory activity against the enzyme, xanthine oxidase. Successful inhibitors are marked as those that gave a comparable or lower ICso value than allo
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Donyai, Parastou. "Xanthine oxidase in oxidative stress : design and evaluation of novel inhibitors." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300381.

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Liu, Shiu Cheong Patrick. "Effects of xanthine oxidase inhibitors in pulmonary hypertension associated with chronic lung disease." Thesis, University of Dundee, 2019. https://discovery.dundee.ac.uk/en/studentTheses/ee8678d8-e7c7-498c-b501-ff5522f32ae5.

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Chronic lung diseases are often complicated with pulmonary hypertension (PH). This can lead to disability and poor prognosis. Oxidative stress has been implicated in the development of PH and right ventricular hypertrophy (RVH).A possible new way to treat lung disease related pulmonary hypertension is allopurinol (a xanthine oxidase inhibitor) which decreases both uric acid and oxidative stress. We hypothesised that allopurinol could regress RVH in patients with pulmonary hypertension associated with chronic lung disease (PH-CLD).In a double-blind, randomised controlled clinical trial, 72 pati
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Rekhraj, Sushma. "The effects of xanthine oxidase inhibitors on left ventricular mass and endothelial function in patients with ischaemic heart disease." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/f4509fb3-a908-4e95-9736-5d99dc85638a.

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Left ventricular hypertrophy is a marker of poor prognosis that commonly affects patients with ischaemic heart disease. It has been associated with an increased risk of all-cause mortality and cardiovascular events including myocardial infarction, heart failure, stroke and arrhythmias. Previous studies of mainly antihypertensive therapies have shown left ventricular hypertrophy to be a reversible risk factor. The LIFE study has shown LVH regression per se to be associated with reduced cardiovascular morbidity and mortality, independent of blood pressure reduction. Therefore, novel ways of regr
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Van, der Walt Mietha Magdalena. "Syntheses of sulfanylphthalimide and xanthine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of adenosine receptors / Mietha Magdalena van der Walt." Thesis, North-West University, 2013. http://hdl.handle.net/10394/9537.

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Currently L-DOPA is the drug most commonly used for the treatment of Parkinson’s disease (PD). However, the long-term use of L-DOPA is associated with the development of motor fluctuations and dyskinesias. Treatment mainly addresses the dopaminergic features of the disease and leaves its progressive course unaffected. An optimal treatment would be a combination of both motor and non-motor symptom relief with neuroprotective properties. Two drug targets have attracted the attention for PD treatment, namely monoamine oxidase B (MAOB) and adenosine A2A receptors. MAO-B inhibitors enhance the elev
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Luna, Giuseppe. "Purine isosters in design and development of novel xanthin oxidase inhibitors." Thesis, Curtin University, 2022. http://hdl.handle.net/20.500.11937/89687.

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This research focuses on the discovery of novel inhibitors of the enzyme xanthine oxidase to assist in the treatment of hyperuricemia and gout. Four different libraries of compounds with a total of 95 molecules were synthesized, purified, characterized and tested in-vitro, with additional molecular docking conducted to rationalize binding interactions. The most active compound was more than 900 times more effective in-vitro than Allopurinol, the current drug of first choice in the market.
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Rajendra, N. S. "Exploring the therapeutic potential of xanthine oxidase inhibitor-AUopurinol, in stable coronary artery disease." Thesis, University of Dundee, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521663.

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Watanabe, Koji. "Pterin-6-aldehyde, an Inhibitor of Xanthine Oxidase, Has Superoxide Anion Radical Scavenging Activity." Kyoto University, 2000. http://hdl.handle.net/2433/151411.

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Mori, Hiroko. "Effects of 6-formylpterin, a xanthine oxidase inhibitor and a superoxide scavenger, on production of nitric oxide in RAW 264.7 macrophages." Kyoto University, 2000. http://hdl.handle.net/2433/151409.

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Zoellner, Kevin Robert. "The preparation and evaluation of xanthinyl analogues as inhibitors of monoamine oxidase B / Kevin R. Zoellner." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1382.

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Books on the topic "Xanthine oxidase inhibitors"

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Richette, Pascal. Principles of gout management. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0044.

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The general goals of gout therapy are to manage acute flares and to prevent recurrences and prevent or reverse the complications of urate deposition by lowering urate levels. The choice of drug should be made on the basis of the patient’s co-morbidities, other medications, and side effect profile. Treatment of flares can be achieved with non-steroidal anti-inflammatory drugs, colchicine, or corticosteroids (systemic or intra-articular). Interleukin-1 blockers could become an alternative in patients contraindicated for traditional anti-inflammatory agents. Lowering of urate levels below monosod
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Kang, Duk-Hee, and Mehmet Kanbay. Urate nephropathy. Edited by Adrian Covic. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0092.

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Gout is a disorder of purine metabolism, characterized by hyperuricaemia and urate crystal deposition within and around the joints. The recognition of increased comorbidity burden in patients with gout rendered it as a systemic disorder rather than simply a musculoskeletal condition. Gout nephropathy (also known as chronic uric acid nephropathy or urate nephropathy) is a form of chronic tubulointerstitial nephritis, induced by deposition of monosodium urate crystals in the distal collecting ducts and the medullary interstitium, associated with a secondary inflammatory reaction. Other renal his
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Book chapters on the topic "Xanthine oxidase inhibitors"

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Das, Dipak K., Richard M. Engelman, Ronald Clement, Hajime Otani, M. Renuka Prasad, and Parinam S. Rao. "Myocardial Salvage by the Free Radical Scavenging Actions of Xanthine Oxidase Inhibitors." In Oxygen Radicals in Biology and Medicine. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5568-7_155.

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Zhang, Ji, and Yingjun Zhang. "Febuxostat (Uloric): A Xanthine Oxidase Inhibitor for the Treatment of Gout." In Innovative Drug Synthesis. John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118819951.ch17.

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Berman, P. A., and L. Human. "Hypoxanthine Depletion Induced by Xanthine Oxidase Inhibits Malaria Parasite Growth in Vitro." In Advances in Experimental Medicine and Biology. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4899-2638-8_37.

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Schneider, Wolfram, Werner G. Siems, Tilman Grune, Christoph Schneider, and Gerhard Gerber. "Mechanisms of Protection of Hepatocytes at Anoxia and Reoxygenation by the Xanthine Oxidase Inhibitor Oxypurinol." In Advances in Experimental Medicine and Biology. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4899-2638-8_76.

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"Xanthine Oxidase Inhibitors." In Crystal-Induced Arthropathies. CRC Press, 2006. http://dx.doi.org/10.3109/9781420020632-27.

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Doehner, Wolfram. "Xanthine Oxidase Inhibitors and Insulin Sensitizers." In Pharmacotherapy of Cachexia. CRC Press, 2005. http://dx.doi.org/10.1201/9780849333798.ch25.

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Doehner, Wolfram. "Xanthine Oxidase Inhibitors and Insulin Sensitizers." In Pharmacotherapy of Cachexia. CRC Press, 2005. http://dx.doi.org/10.1201/9781420048957.ch25.

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"NEW TIGHT BINDING INHIBITORS OF XANTHINE OXIDASE." In Flavins and Flavoproteins 1993. De Gruyter, 1994. http://dx.doi.org/10.1515/9783110885774-125.

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Ayyappan, Prathapan, and Suresh V. Nampoothiri. "Bioactive natural products as potent inhibitors of xanthine oxidase." In Bioactive Natural Products. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-817903-1.00013-9.

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Dalbeth, Nicola, and Lisa K. Stamp. "Xanthine Oxidase Inhibitor Treatment of Hyperuricemia." In Gout & Other Crystal Arthropathies. Elsevier, 2012. http://dx.doi.org/10.1016/b978-1-4377-2864-4.10013-2.

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Conference papers on the topic "Xanthine oxidase inhibitors"

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Matos, Maria João, Fernanda Borges, Lourdes Santana, et al. "Interest of 3-arylcoumarins as xanthine oxidase inhibitors." In The 19th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-b002.

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Matos, Maria João, Benedetta Era, Giovanna Delogu, Francesca Pintus, and Antonella Fais. "In the search of new xanthine oxidase inhibitors: 3-Phenylcoumarins versus 2-phenylbenzofurans." In 5th International Electronic Conference on Medicinal Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecmc2019-06310.

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Shanker, Karuna, Ranjana ., and Dnyaneshwar Umrao Bawankule. "HPLC-based bioactivity profiling for investigation of potent xanthine oxidase inhibitors from Zanthoxylum armatum fruits." In 5th International Electronic Conference on Medicinal Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecmc2019-06410.

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Nuraini, Mega, Subandi Subandi, Muntholib Muntholib, Suharti Suharti, and Eli Hendrik Sanjaya. "Powder sugar apple (Annona squamosa) and watermelon mesocarp (Citrullus lanatus) as pancreatic lipase and xanthine oxidase inhibitors." In II INTERNATIONAL SCIENTIFIC AND PRACTICAL SYMPOSIUM “MATERIALS SCIENCE AND TECHNOLOGY” (MST-II-2022). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0131153.

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Gofur, Amsor Abdul, Trivadila, Luthfan Irfana, and Dyah Iswantini. "In silico screening of active compounds from soursop, mimosa, reeds, and Pandanus leaves as inhibitors for xanthine oxidase." In THE 9TH INTERNATIONAL CONFERENCE OF THE INDONESIAN CHEMICAL SOCIETY ICICS 2021: Toward a Meaningful Society. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0105055.

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Oktavianti, Bella Cintya, Subandi Subandi, Muntholib Muntholib, Evi Susanti, and Eli Hendrik Sanjaya. "Potential of pineapple (Ananas comosus) and cucumber (Cucumis sativus) mesocarp powder as pancreatic lipase and xanthine oxidase inhibitors." In THE 4TH INTERNATIONAL CONFERENCE ON LIFE SCIENCE AND TECHNOLOGY (ICoLiST). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0112945.

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Veeraragavan, Vijayakumar, Radhakrishnan Narayanaswamy, and Rameshkumar Chidambaram. "Molecular docking analysis of imidazole derivatives and polybenzimidazole analogs as inhibitors of superoxide dismutase (SOD) and xanthine oxidase (XO)." In 2017 IEEE International Conference on Smart Technologies and Management for Computing, Communication, Controls, Energy and Materials (ICSTM). IEEE, 2017. http://dx.doi.org/10.1109/icstm.2017.8089213.

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Gancheva, RN, A. Kundurdjiev, M. Ivanova, T. Kundurzhiev, and Z. Kolarov. "THU0453 Heart and carotid changes in fifty-three gout patients treated with xanthine oxidase inhibitors: a follow-up study." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.2516.

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Bredemeier, M., LM Lopes, MA Eisenreich, GK Bongiorno, and S. Hickmann. "OP0269 Effect of xanthine oxidase inhibitors on the incidence of cardiovascular events: a systematic review and meta-analysis of randomised controlled trials." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.2674.

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Gancheva, Rada, Atanas Koundurdjiev, Galina Nikolova, et al. "AB0869 SERUM LEVELS OF ROS PRODUCTS, NO AND ASCORBATE RADICALS IN GOUT PATIENTS ARE NOT ASSOCIATED WITH ARTERIOSCLEROTIC COMMON CAROTID ARTERIES CHANGES AND USE OF XANTHINE OXIDASE INHIBITORS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.1952.

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Reports on the topic "Xanthine oxidase inhibitors"

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Choi, Chiwon, Myeong Gyu Kim, and Jae Hyun Kim. Effect of Xanthine Oxidase Inhibitors on Renal Function in Chronic Kidney Disease Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2024. http://dx.doi.org/10.37766/inplasy2024.5.0024.

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