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Dissertations / Theses on the topic 'Xanthine oxidase inhibitors'

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Published: 5 June 2025

Last updated: 2 August 2025

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1

Leigh, Maria. "Non purine inhibitors of xanthine oxidase." Thesis, University of York, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550273.

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The increase in the occurrence of hyperuricemia and gout in recent years, coupled with side- effects associated with use of the main anti-gout therapeutic, allopurinol, have triggered the search for non-purine alternatives. The first such inhibitor to be made available is Adenurlc", 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid. The aim of this work was to synthesise a small library of non-purine compounds and evaluate their inhibitory activity against the enzyme, xanthine oxidase. Successful inhibitors are marked as those that gave a comparable or lower ICso value than allo

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2

Donyai, Parastou. "Xanthine oxidase in oxidative stress : design and evaluation of novel inhibitors." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300381.

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3

Liu, Shiu Cheong Patrick. "Effects of xanthine oxidase inhibitors in pulmonary hypertension associated with chronic lung disease." Thesis, University of Dundee, 2019. https://discovery.dundee.ac.uk/en/studentTheses/ee8678d8-e7c7-498c-b501-ff5522f32ae5.

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Chronic lung diseases are often complicated with pulmonary hypertension (PH). This can lead to disability and poor prognosis. Oxidative stress has been implicated in the development of PH and right ventricular hypertrophy (RVH).A possible new way to treat lung disease related pulmonary hypertension is allopurinol (a xanthine oxidase inhibitor) which decreases both uric acid and oxidative stress. We hypothesised that allopurinol could regress RVH in patients with pulmonary hypertension associated with chronic lung disease (PH-CLD).In a double-blind, randomised controlled clinical trial, 72 pati

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4

Rekhraj, Sushma. "The effects of xanthine oxidase inhibitors on left ventricular mass and endothelial function in patients with ischaemic heart disease." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/f4509fb3-a908-4e95-9736-5d99dc85638a.

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Left ventricular hypertrophy is a marker of poor prognosis that commonly affects patients with ischaemic heart disease. It has been associated with an increased risk of all-cause mortality and cardiovascular events including myocardial infarction, heart failure, stroke and arrhythmias. Previous studies of mainly antihypertensive therapies have shown left ventricular hypertrophy to be a reversible risk factor. The LIFE study has shown LVH regression per se to be associated with reduced cardiovascular morbidity and mortality, independent of blood pressure reduction. Therefore, novel ways of regr

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5

Van, der Walt Mietha Magdalena. "Syntheses of sulfanylphthalimide and xanthine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of adenosine receptors / Mietha Magdalena van der Walt." Thesis, North-West University, 2013. http://hdl.handle.net/10394/9537.

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Currently L-DOPA is the drug most commonly used for the treatment of Parkinson’s disease (PD). However, the long-term use of L-DOPA is associated with the development of motor fluctuations and dyskinesias. Treatment mainly addresses the dopaminergic features of the disease and leaves its progressive course unaffected. An optimal treatment would be a combination of both motor and non-motor symptom relief with neuroprotective properties. Two drug targets have attracted the attention for PD treatment, namely monoamine oxidase B (MAOB) and adenosine A2A receptors. MAO-B inhibitors enhance the elev

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6

Luna, Giuseppe. "Purine isosters in design and development of novel xanthin oxidase inhibitors." Thesis, Curtin University, 2022. http://hdl.handle.net/20.500.11937/89687.

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This research focuses on the discovery of novel inhibitors of the enzyme xanthine oxidase to assist in the treatment of hyperuricemia and gout. Four different libraries of compounds with a total of 95 molecules were synthesized, purified, characterized and tested in-vitro, with additional molecular docking conducted to rationalize binding interactions. The most active compound was more than 900 times more effective in-vitro than Allopurinol, the current drug of first choice in the market.

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7

Rajendra, N. S. "Exploring the therapeutic potential of xanthine oxidase inhibitor-AUopurinol, in stable coronary artery disease." Thesis, University of Dundee, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521663.

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8

Watanabe, Koji. "Pterin-6-aldehyde, an Inhibitor of Xanthine Oxidase, Has Superoxide Anion Radical Scavenging Activity." Kyoto University, 2000. http://hdl.handle.net/2433/151411.

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9

Mori, Hiroko. "Effects of 6-formylpterin, a xanthine oxidase inhibitor and a superoxide scavenger, on production of nitric oxide in RAW 264.7 macrophages." Kyoto University, 2000. http://hdl.handle.net/2433/151409.

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10

Zoellner, Kevin Robert. "The preparation and evaluation of xanthinyl analogues as inhibitors of monoamine oxidase B / Kevin R. Zoellner." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1382.

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11

Xu, Xiu Yun, and 許秀蘊. "Studies on xanthine oxidase inhibitors." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/43286644716975478129.

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12

Chu, Yung-Hung, та 朱涌弘. "Purification and Characterization of α-Glucosidase and Xanthine Oxidase Inhibitors from Rhodiola Crenulata". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/99501828733426495264.

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碩士<br>輔仁大學<br>食品科學系碩士班<br>101<br>Rhodiola crenulata (R. crenulata) is mainly distributed in the high cold region of Yunnan and Sichuan province. In the current study, many researches investigated that R. crenulata water extracts have the inhibitory activities to α-glucosidase. α-Glucosidase inhibitor can use to control postprandial hyperglycemia therapy for type 2 diabetes. In addition, R. crenulata water extracts have xanthine oxidase (XO) inhibitory activities. XO inhibitors have potency to block the synthesis of uric acid and use for gout treatment. The purpose of this study is to extract a

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13

Cavalheiro, Eunice Cerdeira Soares. "Synthesis of 5-methylene(thio)ureas (thio)barbiturates as potential xanthine oxidase inhibitors." Master's thesis, 2017. http://hdl.handle.net/10400.6/7881.

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Barbituric acids have an important role on the development of new drugs due to their various biological effects. Nowadays, these derivatives can be used as sedatives, hypnotics, anticonvulsants and anesthetics. Moreover, they possess antibacterial, antioxidant and anticancer activities. Most of these pharmacological properties are generally due to different side groups attached on C5 of the pyrimidine ring. By means of their general chemical and physical properties, barbituric acid and its thio-analogue are great precursors for the synthesis of several heterocyclic bioactive compounds. Some st

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14

"Evaluation of xanthine oxidase inhibitory and antioxidant activities of compounds from natural sources." 2005. http://library.cuhk.edu.hk/record=b5892399.

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Lam Rosanna Yen Yen.<br>Thesis submitted in: September 2004.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 142-154).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Chinese Abstract --- p.iii<br>Acknowledgements --- p.v<br>Table of Contents --- p.vi<br>List of Abbreviations --- p.xii<br>List of Figures --- p.xv<br>List of Tables --- p.xix<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Reactive oxygen species --- p.1<br>Chapter 1.1.1 --- Intracellular sources of ROS --- p.1<br>Chapter 1.1.2 ---

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15

Tsai, shing-jen, and 蔡幸真. "Inhibitory effects of phenolics on xanthine oxidase." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/18039575583561048525.

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碩士<br>國立臺灣大學<br>藥學研究所<br>84<br>partI: Thirty-eight phenolics have been tested for their inhibitory effects on xanthine oxidase,the results showed that the benzophenones,3,4,5,2',3',4'-hexahydroxybenzophenone, 2,2', 4,4'-tetrahydroxybenzophenone and 2,3',4,4'-tetrahydroxybenzo phenone showed potent inhibitory activities. The coumarin, 5,7- dihydroxy-4-methylcoumarin also displayed strong activity on xanthine oxidase inhibition. PartII:Xanthine-xanthine oxidase- cytochrome C system was used i

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16

Zhang, Wen Xing, and 張文倖. "Inhibitory effects of phenolic compounds on xanthine oxidase." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/87773642529509493342.

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17

Yan, Guey-Fen, and 顏桂芬. "Inhibitory effects of phenolic carboxylic acid analogues on xanthine oxidase." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/44913666564823127553.

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碩士<br>國立臺灣大學<br>藥學研究所<br>83<br>Part I. Xanthine Oxidase Inhibitors from Ophioglossum petiolatum Hook.Ophioglossum petiolatum Hook. (Ophioglossaceae) has been used in folk medicine for inflammation, various pains, tumors, jaundice, fever. In the search for active principles, the rhizoma of the plant were extracted with ethanol. Two flavonoids, quercetin-3- methylether (OP-1) and 3- hydroxymethylluteolin (OP-2) were isolated and characterized from the ethyl acetate soluble fraction of the ethanolic extract. Each fraction and compounds OP-1 and OP-2 were tes

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18

Lin, Yu-Wen, and 林郁雯. "Antioxidant activities and xanthine oxidase inhibitory effects of medicinal plants." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/81024570021173713106.

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碩士<br>國立臺灣大學<br>農藝學研究所<br>103<br>With the economy standards improved, people in Taiwan have changed in eating habits and decreased physical activity, so there is a substantial increase in the prevalence of chronic diseases. It is increasingly starting to pay attention to health care. Natural medicinal plants used in the past by various ethnic groups in the treatment of disease, and many of today''s medicine and health food are extracted from the active ingredient purified or re-modified derived of natural medicinal plants. Although the current study have known for a number of medicin

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19

Huang, Chi-Ya, and 黃琪雅. "Studies on Xanthine Oxidase Inhibitory Activity of Pistacia chinensis Bunge Leaf oil." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/12306117864143346249.

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碩士<br>國立臺灣大學<br>森林環境暨資源學研究所<br>102<br>The aim of this study was to evaluate the xanthine oxidase inhibitiory activities of oils and extracts from Pistacia chinensis leaf and twig. According to xanthine oxidase inhibition results, leaf oil exhibited the most excellent performance whether hypoxanthine or xanthine was used as the substrate. Among six fractions of leaf oil, E1 fraction possessed the best xanthine oxidase inhibition activity. Results from the chemical composition analysis of leaf oil and E1 fraction, both specimens showed limonene was the main compound with the relative content of

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20

Shiao-Hui, Lee, and 李曉暉. "The inhibiton of xanthine oxidase and cell apoptosis by tannic acid." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/56976307799129292683.

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碩士<br>台北醫學院<br>醫學研究所<br>86<br>The major biochemical feature of gout is an elevated level of uric acid in the serum. In humans, uric acid is the final product of purine degradation. Xanthine oxidase converts hypoxanthine to xanthine and then to uric acid, and also causes generation of the reactive oxygen species (hydrogen peroxide and superoxide anion radical). In this report, we demonstrate that tannic acid and its metabolites, such as gallic acid and pyrogallol, inhibit xanthine oxidase. Determination of IC50 of var

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21

KUO, YU-LING, та 郭育伶. "Preparation and characterization of zein-curcumin analogue nanoparticles with α-glucosidase and xanthine oxidase inhibitory activities". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/7kg9yk.

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碩士<br>輔仁大學<br>食品科學系碩士班<br>107<br>Curcumin (CM) is a natural lipophilic polyphenol with a variety of pharmacological properties, that provide antioxidizing, antiinflammatory, antimicrobial, antiviral, antirheumatic, anticancer, and neuroprotective effects. However, curcumin is limited in terms of water-solubility, and curcumin analogues as well. Researchers have recently begun using biopolymers to encapsulate hydrophobic compounds in order to improve their bioavailability. The objective of this study was to evaluate the feasibility of using zein nanoparticles as an oral delivery vehicle for cur

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22

Lee, Fu-Wei, and 李馥葳. "The structure-activity relationship of cinnamic acid derivatives on reactive oxygen species scavenging and xanthine oxidase inhibitory activities." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/49468018915766371013.

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23

Chang, Yu-Huey, and 張玉慧. "Inhibitory action of the constituents from the stems of Bougainvillea spectabilis Willd and phenolic compounds on xanthine oxidase." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/00283897951369972415.

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碩士<br>國立臺灣大學<br>藥學研究所<br>81<br>Bougainvillea spectabilis Willd belongs to Nyctaginaceae and its stems have been used in folk remedy for hepatitis in Taiwan. The extract of the leaves could promote producing highly active virus inhibiting agent, and the whole plant showed anti-baterial activities. In the search for bioactive constituents, the stems of the plant were extraceted and fractionated, the mixture ( 22,23-dihydrospinasterol and spinasterol ) and caffeic acid were isolated and charac

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24

Lai, chih-hao, and 賴志豪. "Part 1:Inhibitory effects of phenolic compounds on xanthine oxidase. Part 2: Studies on steroidogenic effect of Cinnamomum osphloeum Kaneh." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/09244632248116756722.

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碩士<br>國立臺灣大學<br>藥學系<br>85<br>PartⅠ: Inhibitory Effects of Phenolic Compounds on Xanthine Oxidase It has been previously reported that several groups of phenolic compoundsdisplay very potent xanthine oxidase inhibition. The enzyme, xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid, which has (max 295 nm forming the basis for a spectrophotometric assay of the activity of xanthine oxidase . In this study, several phenolic compounds

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25

Heineke, André [Verfasser]. "Allopurinol, ein Xanthin-Oxidase-Inhibitor, reduziert das linksventrikuläre Remodeling und verbessert die myokardiale Funktion nach experimentellem Myokardinfarkt / vorgelegt von André Heineke." 2007. http://d-nb.info/986824887/34.

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26

Ho, An-chieh, and 何安杰. "Part I: Studies on the Matrix Metalloproteinases (MMPs) Inhibitory Effect of Paeonia suffruticosa Part II: Inhibition of Xanthine Oxidase by the Constituents of Paeonia suffruticosa, Pyrimidines, Benzotriazoles and Analogues." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/30822329432103892195.

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碩士<br>台北醫學院<br>藥學研究所<br>88<br>Abstract Part Ⅰ. Studies on the Matrix Metalloproteinases (MMPs) Inhibitory Effect of Paeonia suffruticosa Paeonia suffruticosa is a plant of Ranunculaceae. According to Chinese herb literature, Paeonia suffruticosa has been used as regulate blood, remove blood stasis and promote blood circulation. Paeonia suffruticosa has been reported to be used in hemostasis, antipyretic, anti-microbial, anti-inflammatory, anti-hypertention, anti-cholingergic and CNS inhibiton. In clinical, it also be used in treatment of lung cancer, hepatoma and

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