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Journal articles on the topic 'Xanthones g- Mangosteen'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Li, Rui, Baskaran Stephen Inbaraj, and Bing-Huei Chen. "Quantification of Xanthone and Anthocyanin in Mangosteen Peel by UPLC-MS/MS and Preparation of Nanoemulsions for Studying Their Inhibition Effects on Liver Cancer Cells." International Journal of Molecular Sciences 24, no. 4 (2023): 3934. http://dx.doi.org/10.3390/ijms24043934.

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Mangosteen peel, a waste produced during mangosteen processing, has been reported to be rich in xanthone and anthocyanin, both of which possess vital biological activities such as anti-cancer properties. The objectives of this study were to analyze various xanthones and anthocyanins in mangosteen peel by UPLC-MS/MS for the subsequent preparation of both xanthone and anthocyanin nanoemulsions to study their inhibition effects on liver cancer cells HepG2. Results showed that methanol was the optimal solvent for the extraction of xanthones and anthocyanins, with a total amount of 68,543.39 and 29

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Ibrahim, Sabrin R. M., Gamal A. Mohamed, Mahmoud A. Elfaky, et al. "Mangostanaxanthone VII, a new cytotoxic xanthone from Garcinia mangostana." Zeitschrift für Naturforschung C 73, no. 5-6 (2018): 185–89. http://dx.doi.org/10.1515/znc-2017-0122.

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Abstract Garcinia mangostana L. (the queen of fruits, mangosteen, family Guttiferae) is a wealthy source of xanthones. The CHCl3 soluble fraction of the air-dried pericarps of G. mangostana provided a new xanthone: mangostanaxanthone VII (5), along with four known xanthones: mangostanaxanthones I (1) and II (2), gartanin (3) and γ-mangostin (4). The structural verification of these metabolites was achieved by different spectral techniques, including UV, IR, 1D and 2D NMR and HRESIMS. The new metabolite was assessed for cytotoxic potential, using sulforhodamine B (SRB) assay towards the A549 an

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Moch, Dennys Setyo Purnomo. "Mangosteen's Skin (Garcinia mangostana L) as Reducing Blood Sugar Levels in Diabetes Mellitus: Myth or Facts?" World Journal of Advanced Research and Reviews 23, no. 2 (2024): 1368–70. https://doi.org/10.5281/zenodo.14856103.

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A 56-year-old woman with diabetes mellitus experienced a reduction in blood glucose levels after consuming boiled mangosteen's skin water for 2 weeks. The patient's blood glucose levels decreased from 223 mg/dL to 206 mg/dL. This case report is supported by previous research on the antihyperglycemic effects of xanthones γ-mangosteen, a compound found in mangosteen's skin. The study suggests that mangosteen's skin may be a potential natural remedy for reducing blood sugar levels in patients with diabetes mellitus, and further research is warranted to explore its therapeutic potential.&nbs

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Zamarudin, Zalikha binti, Muhamad Shirwan Bin Abdullah Sani, Noor Faizul Hadry Nordin, Azura Amid, and Amalia Mohd Hashim. "Mangosteen (Garcinia mangostana): Extraction, purification, bioactivities and toxicities." Halalpshere 3, no. 2 (2023): 13–27. http://dx.doi.org/10.31436/hs.v3i2.74.

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Mangosteen (Garcinia mangostana) is a popular tropical fruit known as ‘the queen of fruits’ due to its delicious flavour. It comprises phytochemicals, flavonoids, and polyphenols such as xanthones, anthocyanins, and phenolic acids. The G. mangostana pericarp, seed, and flesh bioactive compounds have been shown to have anticancer, antitumor, wound healing, anti-inflammatory, antigenotoxic, antioxidative, antimicrobial, and antiviral properties. This review focuses on the bioactivity of G. mangostana, with the most common bioactive compound discovered being xanthone, which is frequently used in

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Meechai, Imron, Rokeeyah Suha, Nurihan Daleng, Isma-ae Chelong, and Acharee Suksuwan. "Synergistic Effect of Pericarp of Mangosteen and Propolis from Stingless Bee Extracts on Nitric Oxide Scavenging Activity." Journal of Tropical Pharmacy and Chemistry 7, no. 1 (2023): 10–15. http://dx.doi.org/10.25026/jtpc.v7i1.458.

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The aim of this research is to study the synergistic effect on the nitric oxide scavenging activity of mangosteen pericarp and the stingless bee (Tetragonula laviceps) propolis extracts and their phytochemical constituents. The propolis and mangosteen pericarp were extracted by reflux method with ethanol. TPC and TFC of propolis extract were 123.73±2.80 mg GAE/g extract and 70.65±11.21 mg QE/g extract, respectively, and mangosteen pericarp extract was 387.93±15.10 mg GAE/g extract and 87.00±5.06 mg QE/g extract, respectively. The ESI-LC-MS data displayed that both extracts have a variety of ph

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Chung, Tsair-Wang, and Irwan Saleh Kurniawan. "Optimization of the Extraction System of Total Phenolic from Garcia mangostana using Response Surface Methodology." Journal of Physics: Conference Series 2542, no. 1 (2023): 012019. http://dx.doi.org/10.1088/1742-6596/2542/1/012019.

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Abstract Mangosteen (Garcia mangostana) consist of 40% flesh and 60% pericarp. Mangosteen pericarp has unpleasant taste of bitterness and usually disposed as waste. However, mangosteen pericarp contains xanthones which are polyphenolic compound that proven has high antioxidant activity were found abundantly in mangosteen pericarp. This study aims to investigate water extraction optimum operating conditions to be applied in industry by using RAM (response surface methodology) for the recovery of total phenolic extract from the pericarp of mangosteen. Box-Behnken experimental design used 3 facto

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Albuquerque, Bianca R., Maria Inês Dias, José Pinela, et al. "Insights into the Chemical Composition and In Vitro Bioactive Properties of Mangosteen (Garcinia mangostana L.) Pericarp." Foods 12, no. 5 (2023): 994. http://dx.doi.org/10.3390/foods12050994.

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The industrial processing of mangosteen (Garcinia mangostana L.) generates high amounts of waste, as ~60% of the fruit is formed by an inedible pericarp. However, its pericarp has been explored as a source of xanthones; nevertheless, studies addressing the recovery of other chemical compounds from such biomass are still scarce. Hence, this study intended to elucidate the chemical composition of the mangosteen pericarp, including fat-soluble (tocopherols and fatty acids) and water-soluble (organic acids and phenolic compound non-xanthones) compounds present in the following extracts: hydroethan

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8

Faisal, Muhammad, Unggul Pundjung Juswono, Didik Rahadi Santoso, and Chomsin Sulistya Widodo. "Effectiveness of Herbal Medicine Mangosteen Peel Extract (Garcinia mangostana) to Prevent Free Radicals Occurrence and Decrease in Hemoglobin Levels in the Blood Caused by Diabetes Mellitus." Trends in Sciences 22, no. 3 (2025): 9250. https://doi.org/10.48048/tis.2025.9250.

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Diabetes mellitus is associated with a decrease in hemoglobin levels. The relationship between the 2 is inversely proportional. When blood sugar levels increase, it triggers glycation, enhancing xanthine oxidase activity and free radical formation. This phenomenon causes reactive oxygen species (ROS) to emerge and reduces oxygen in the blood, decreasing hemoglobin levels. This study aims to analyze the effectiveness of mangosteen peel extract (Garcinia mangostana) in preventing the formation of free radicals and reducing hemoglobin levels in the blood due to diabetes mellitus. This study was c

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John, Oliver D., Peter Mouatt, Sunil K. Panchal, and Lindsay Brown. "Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats." Nutrients 13, no. 2 (2021): 319. http://dx.doi.org/10.3390/nu13020319.

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The pulp of the purple mangosteen, Garcinia mangostana, is a popular tropical fruit but the rind containing xanthones such as α-mangostin together with procyanidins and anthocyanidins is usually discarded as waste. However, this rind has been used in South-East Asia for diarrhoea, dysentery, skin infections and wounds. As xanthones have reported anti-inflammatory and antioxidant responses, this study has determined the bioactive compounds and evaluated the effects of G. mangostana rind on physiological, metabolic, liver and cardiovascular parameters in rats with diet-induced metabolic syndrome

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Alanazi, Abdullah I. R., Hossam M. Abdallah, Hagar M. Mohamed, et al. "Cytotoxic Metabolites from Pericarp of Garcinia mangostana." Journal of Pharmacy and Bioallied Sciences 17, no. 2 (2025): 56–60. https://doi.org/10.4103/jpbs.jpbs_991_25.

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Background: The pericarp of Garcinia mangostana (mangosteen) has been used as a medicinal agent by Southeast Asians for centuries in the treatment of skin infections and wounds. Its main active constituents were xanthones and phenolic compounds. The plant and its metabolites possessed diverse bioactivities. Methods: A methanolic extract of G. mangostana pericarp was subjected to solvent partitioning and chromatographic purification to isolate α-mangostin (1), β-mangostin (2), gartanin (3), garcinone C (4), garcinone D (5), and (+)-2R,3R-taxifolin-3-O-α-L-rhamnoside (astilbin) (6) that were ide

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O. B. I. P. A, Yanesti, Astawa Astawa, I. K. Sumadi, Bulkaini Bulkaini, and Djoko Kisworo. "The Effect of Giving Mangosteen Peel Extract (Garcinia mangostana L.) in Drinking Water on Broiler Performance." Jurnal Biologi Tropis 24, no. 2 (2024): 853–62. http://dx.doi.org/10.29303/jbt.v24i2.6663.

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Mangosteen peel is a waste that can be used as a feed additive. The function of xanthones in mangosteen peel as anti-tumoural, antioxidant, anti-inflammatory, anti-allergic, anti-microbial, anti-fungal, and anti-virus. The research aims to determine the effect of administering mangosteen peel extract in drinking water on the performance of broiler chickens for 35 days which was carried out in Dajan Peken Village, Tabanan District, Tabanan Regency, Bali. The design used was a Completely Randomized Design (CRD) with 4 treatments and 4 cage units as replications. Each cage unit contains 4 broiler

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Rizki, Tri, Sedarnawati Yasni, Sri Yuliani та Tjahja Muhandri. "PENGEMBANGAN ENKAPSULAT NANOEMULSI EKSTRAK KULIT MANGGIS (Garcinia mangostana L.): UJI DISOLUSI IN VITRO DAN AKTIVITAS PENGHAMBATAN ENZIM Α-AMILASE". JURNAL TEKNOLOGI PANGAN DAN ILMU PERTANIAN (JIPANG) 6, № 02 (2024): 38–47. https://doi.org/10.36526/jipang.v6i02.4642.

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This study aims to develop a nanoemulsion encapsulation system for mangosteen peel extract to enhance the stability and bioavailability of its bioactive compounds, primarily xanthones. The research focused on optimizing the ethanol concentration for extraction, the surfactant type for nanoemulsion synthesis, and the encapsulant materials. Encapsulation efficiency, dissolution characteristics, and α-amylase inhibition activity were evaluated to assess its potential for diabetes management. Encapsulation using maltodextrin and gum arab achieved the highest efficiency (97.93%) and antioxidant cap

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Wulandari, Pugar Arga Cristina, Zulfa Nailul Ilmi, Saikhu Akhmad Husen, et al. "Wound Healing and Antioxidant Evaluations of Alginate from Sargassum ilicifolium and Mangosteen Rind Combination Extracts on Diabetic Mice Model." Applied Sciences 11, no. 10 (2021): 4651. http://dx.doi.org/10.3390/app11104651.

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A diabetic foot ulcer is an open wound that can become sore and frequently occurs in diabetic patients. Alginate has the ability to form a hydrophilic gel when in contact with a wound surface in diabetic patients. Xanthones are the main compounds of mangosteen rind and have antibacterial and anti-inflammatory properties. The purpose of this research was to evaluate the wound healing and antioxidants assay with a combination of alginate from S. ilicifolium and mangosteen rind combination extracts on a diabetic mice model. The characterization of alginate was carried out by size exclusion chroma

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Nawawi, Nur Izzati Mohamed, Giroon Ijod, Faridah Abas, Nurul Shazini Ramli, Noranizan Mohd Adzahan, and Ezzat Mohamad Azman. "Influence of Different Drying Methods on Anthocyanins Composition and Antioxidant Activities of Mangosteen (Garcinia mangostana L.) Pericarps and LC-MS Analysis of the Active Extract." Foods 12, no. 12 (2023): 2351. http://dx.doi.org/10.3390/foods12122351.

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Mangosteen pericarps (MP) often end up as agricultural waste despite being rich in powerful natural antioxidants such as anthocyanins and xanthones. This study compared the effect of different drying processes and times on phenolic compounds and antioxidant activities of MP. Fresh MP were subjected to 36 and 48 h of freeze-drying (−44 ± 1 °C) and oven-drying (45 ± 1 °C), and 30 and 40 h of sun-drying (31 ± 3 °C). The samples were analyzed for anthocyanins composition, total phenolic content (TPC), total flavonoid content (TFC), antioxidant activities, and color characteristics. Analysis of liq

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Faisal, Muhammad Ali, Ika Kustiyah Oktaviyanti, Hidayat Sujuti, and Achmad Rudijanto. "Virtual Screening of the Active Components of Garcinia mangostana Linn. Potentially Inhibiting the Interaction of Advanced Glycation End-products and their Receptor." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 921–27. http://dx.doi.org/10.3889/oamjms.2020.5505.

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BACKGROUND: Mangosteen (Garcinia mangostana L.) is a plant that contains various secondary metabolite compounds, one of which is xanthone. Xanthone in mangosteen has a variety of beneficial biological and medical effects, one of which is an antioxidative, anti-inflammatory, and antiapoptotic agent. AIM: The aim of the study was to perform the selection of any xanthone in mangosteen pericarp that have potentially inhibit the interaction of AGEs and RAGE. METHODS: The analysis was made in silico by docking method using software Hex 8.0. The docking was done between AGEs-RAGE, also be

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Chadon Alphonsine Assemian, Inès Christelle, Abdelhakim Bouyahya, Nadia Dakka, and Youssef Bakri. "Garcinia Mangostana Leaf Extracts from Ivory Coast Possess Remarkable Antioxidant, Anti-Inflammatory, and Cytotoxicological Properties." Biomedical and Pharmacology Journal 12, no. 2 (2019): 571–78. http://dx.doi.org/10.13005/bpj/1676.

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Garcinia mangostana L. is medicinal plant. Its fruit, the mangosteen contains many bioactive xanthones. This study investigates the potential of organic leaf extracts of G. mangostana grown in Ivory Coast. We tested two organic leaf extracts: G. mangostana aqueous ethanolic leaf extract (ethanol: water, 80:20 v/v) (GMLE) and dichloromethane leaf extract (GMLD). We measured total phenolic and total Flavonoids. We analysed the in vitro anti-inflammatory, anti-radical and anti-proliferative activities of leaf extracts. Ethanol leaf extract showed a considerable amount of phenolic content (328.78±

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Sujono, Sujono, and Anik Nuryati. "Uji Antibakteri Ekstrak Metanol Kulit Buah Manggis (garcinia mangostana l.) Terhadap Staphyllococcus aureus dan Escherechia coli." Jurnal Teknologi Laboratorium 6, no. 1 (2017): 25. http://dx.doi.org/10.29238/teknolabjournal.v6i1.60.

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Alfa mangostin, gamma-mangostin and xanthone group compounds are secondary metabolites contained in mangosteen (G. mangostana L.) which can be isolated from the fruit, bark, leaves and rind of mangosteen. All three compounds were shown to inhibit stronger against Mycobacterium tuberculosis. Alfa mangostin also active against Staphylococcus aureus and Enterococcus bacteria that are resistant to vancomisin and methicillin. Objective of this study to determine the antibacterial activity of methanol extract of mangosteen rind against Staphyllococcus aureus and Escherechia coli in vitro. Anti

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Adhimas Wicaksono, Yuriz Bakthiar, and MI Widiastuti. "Nanostructured Garcinia mangostana Extract Modulates RANKL Signaling and Calcium Homeostasis to Enhance Fracture Healing in Diabetic Bone: A Systematic Review of In Vivo Evidence." Bioscientia Medicina : Journal of Biomedicine and Translational Research 9, no. 4 (2025): 7149–62. https://doi.org/10.37275/bsm.v9i4.1263.

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Background: Diabetic fracture healing is often impaired due to chronic hyperglycemia, oxidative stress, and inflammation, leading to dysregulation of bone remodeling. Receptor activator of nuclear factor kappa-Β ligand (RANKL) and calcium homeostasis are critical regulators of this process. Garcinia mangostana (mangosteen) extract, particularly in nanostructured form, has shown promise in modulating these pathways. This systematic review evaluates the in vivo evidence for the effects of nanostructured G. mangostana extract on RANKL signaling, calcium levels, and bone healing outcomes in diabet

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Kureshi, Azazahemad A., Chirag Dholakiya, Tabaruk Hussain, et al. "Simultaneous identification and quantification of three biologically active xanthones in Garcinia species using a rapid UHPLC-PDA method." Acta Chromatographica 32, no. 3 (2020): 179–88. http://dx.doi.org/10.1556/1326.2019.00655.

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Xanthones are well recognized as chemotaxonomic markers for the plants belonging to the genus Garcinia. Xanthones have many interesting pharmacological properties. Efficient extraction and rapid liquid chromatography methods are essentially required for qualitative and quantitative determination of xanthones in their natural sources. In the present investigation, fruit rinds extracts of 8 Garcinia species from India, were prepared with solvents of varying polarity. Identification and quantification of 3 xanthones, namely, α-mangostin, β-mangostin, and γ-mangostin in these extracts were carried

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Panthong, Kanda, Nongporn Hutadilok-Towatana, and Ampai Panthong. "Cowaxanthone F, a new tetraoxygenated xanthone, and other anti-inflammatory and antioxidant compounds from Garcinia cowa." Canadian Journal of Chemistry 87, no. 11 (2009): 1636–40. http://dx.doi.org/10.1139/v09-123.

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A new tetraoxygenated xanthone, cowaxanthone F (1), as well as four known compounds, morelloflavone (2), volkensiflavone (3), morelloflavone-7″-O-glucoside (fukugiside, 4), and 1,6-dihydroxyxanthone (5), were isolated from the crude acetone extract of the twigs of Garcinia cowa (Guttiferae). All compounds (1–5) were tested for antioxidant activity against DPPH (diphenylpicrylhydrazyl), hydroxyl, and superoxide radicals; only morelloflavone (2) and morelloflavone-7″-O-glucoside (4) exhibited high potency. Eight tetraoxygenated xanthones from the fruits of G. cowa , cowaxanthones A–D (6–9), cowa

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Kureshi, Azazahemad A., Chirag Dholakiya, Tabaruk Hussain, et al. "Simultaneous Identification and Quantification of Three Xanthones and Two Polyisoprenylated Benzophenones in Eight Indian Garcinia Species Using a Validated UHPLC-PDA Method." Journal of AOAC INTERNATIONAL 102, no. 5 (2019): 1423–34. http://dx.doi.org/10.1093/jaoac/102.5.1423.

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Abstract Background: Xanthones and polyisoprenylated benzophenones (PIBs) are two important classes of plant secondary metabolites with a wide range of bioactivities. Garcinia species synthesize numerous xanthones and PIBs. As per the literature, no data claiming simultaneous identification and quantification of three xanthones, α-mangostin, β-mangostin, γ-mangostin, and two PIBs, xanthochymol, isoxanthochymol, were found. Methods: A validated ultra-HPLC (UHPLC)-photodiode array (PDA) method for the simultaneous identification and quantification of five compounds in different extracts of eight

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Aravind, Aravindakshanpillai P. Anu, Renu Pandey, Brijesh Kumar, Kumarapillai R. T. Asha, and Koranappallil B. Rameshkumar. "Phytochemical Screening of Garcinia travancorica by HPLC-ESI-QTOF Mass Spectrometry and Cytotoxicity Studies of the Major Biflavonoid Fukugiside." Natural Product Communications 11, no. 12 (2016): 1934578X1601101. http://dx.doi.org/10.1177/1934578x1601101216.

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Qualitative screening of multiclass secondary metabolites present in the fruits, leaves and stem bark extracts of Garcinia travancorica was carried out using HPLC-QTOF-MS analysis. Twenty-three compounds were identified in the fruits, leaves and stem bark, including two acids (hydroxycitric acid and hydroxycitric acid lactone), eight biflavonoids (morelloflavone, GB-1, GB-1a, GB-2, GB-2a, fukugiside, xanthochymusside and GB-1a glucoside), nine xanthones (α-mangostin, γ-mangostin, 1,5-dihydroxy-3-methoxyxanthone, garciniaxanthone E, 4-(1,1-dimethylprop-2-enyl)-1,3,5,8-tetrahydroxy-xanthone, gar

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Dahlizar, Sabrina, Putri Alifia Agustina, Narti Fitriana, Abdi Wira Septama, Sofa Fajriah, and Herdini Herdini. "Pengaruh Karbopol dan Propilen Glikol terhadap Laju Penetrasi Sediaan Emulgel Xanthone Rich Fraction dari Kulit Buah Manggis (Garcinia mangostana L.)." ALCHEMY:Journal of Chemistry 11, no. 2 (2023): 32–42. http://dx.doi.org/10.18860/al.v11i2.20520.

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Xanthone Rich Fraction (XRF) derived from mangosteen rind (G. mangostana L.) contains α-mangostin possessed antioxidant property. It may be used to prevent aging (anti-aging). This study aims to determine the effect of adding Carbopol as a gelling agent and propylene glycol as an enhancer on the physical characteristics and penetration rate of the emulgel. Four different formulas were prepared, F1 without a gelling agent (Carbopol) and enhancer (propylene glycol), F2 without a gelling agent (carbopol), F3 using a gelling agent (carbopol), and F4 using a gelling agent (carbopol) and enhancer (p

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Majdalawieh, Amin F., Bayan K. Khatib та Tala M. Terro. "α-Mangostin Is a Xanthone Derivative from Mangosteen with Potent Immunomodulatory and Anti-Inflammatory Properties". Biomolecules 15, № 5 (2025): 681. https://doi.org/10.3390/biom15050681.

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α-Mangostin, a bioactive xanthone derived from the Garcinia mangostana L. Clusiaceae (G. mangostana) fruit, has demonstrated significant anti-inflammatory and immunomodulatory properties. Chronic inflammation plays a critical role in the pathogenesis of various diseases, including metabolic disorders, autoimmune conditions, and cancer. Conventional anti-inflammatory therapies, such as non-steroidal anti-inflammatory drugs (NSAIDs), often carry undesirable side effects, prompting the need for safer, natural alternatives. This review consolidates the existing literature on the mechanisms by whic

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Budiandari, Rahma Utami, Syaiful Anam, and Lukman Hudi. "Karakteristik jelly drink rumput laut (Euchema spinosum) dengan penambahan kulit buah manggis (Garcinia mangostana L.) sebagai pangan fungsional." Teknologi Pangan : Media Informasi dan Komunikasi Ilmiah Teknologi Pertanian 13, no. 2 (2022): 221–26. http://dx.doi.org/10.35891/tp.v13i2.3264.

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Mangosteen fruit (Garcinia mangostana L.) , one of Indonesian fruits, contains 70-75% skin fruit. The mangosteen skin contains xanthone compounds which are antioxidants, 107.76 mg/100 g fresh fruit. Fresh Mangosteen skin is easily damaged, it needs to be processed in order to have a long shelf life, by processing it into a jelly drink. Mangosteen skin extract is formulated with porridge of Eucheuma spinosum to make a jelly drink.This study aimed to determine the effect of the proportion of mangosteen skin extract and seaweed porridge through the physical characteristics, chemical of mangosteen

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Chin, Young-Won, Eunjin Shin, Bang Yeon Hwang, and Mi Kyeong Lee. "Antifibrotic Constituents from Garcinia mangostana." Natural Product Communications 6, no. 9 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600915.

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From the CHCl3-soluble fraction of the fruits of Garcinia mangostana (Clusiaceae), six xanthone derivatives, α-mangostin (1), γ-mangostin (2), gartanin (3), deoxygartanin (4), 1-isomangstanin (5) and garcinone E (6), were isolated. All these compounds significantly inhibited HSC-T6 viability as assessed by employing HSC-T6 hepatic stellate cells as an in vitro assay system. Among them, compounds 1 and 2, the most potent and major constituents of G. mangostana, inhibited HSC-T6 viability in dose- and time-dependent manners. In addition, compounds 1 and 2 significantly reduced collagen content,

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Permana, Asep W., Siti Mariana Widayanti, Sulusi Prabawati, and Dondy A. Setyabudi. "Sifat Antioksidan Bubuk Kulit Buah Manggis (Garcinia Mangostana L.) Instan Dan Aplikasinya Untuk Minuman Fungsional." Jurnal Penelitian Pascapanen Pertanian 9, no. 2 (2017): 88. http://dx.doi.org/10.21082/jpasca.v9n2.2012.88-95.

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Kulit buah manggis (KBM) merupakan bagian terbesar dari buah manggis (Garcinia mangostana L.) yang dikategorikan sebagai limbah. Studi fitokimia menunjukkan bahwa senyawa antioksidan dalam KBM, terutama xanthone, antosianin dan kelompok senyawa fenoliklainnya memiliki sifat fungsional dan manfaat untuk kesehatan seperti antidiabetes, antikanker, antiinflamasi, meningkatkan kekebalan tubuh, antibakteri, antifungi, antiplasmodial, dan sebagainya. Berbagai produk olahan berbasis KBM segar sudah berkembangkan di pasaran, seperti jus, konsentrat dan produk lainnya. Pada tahun 2009 telah dihasilkan

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Khamphukdee, Charinya, Ibrahim Turkmani, Yutthana Chotritthirong та ін. "Effects of the Bark Resin Extract of Garcinia nigrolineata on Chronic Stress-Induced Memory Deficit in Mice Model and the In Vitro Monoamine Oxidases and β-Amyloid Aggregation Inhibitory Activities of Its Prenylated Xanthone Constituents". Molecules 27, № 9 (2022): 3014. http://dx.doi.org/10.3390/molecules27093014.

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The present study describes investigation of the effects of the bark resin extract of Garcinia nigrolineata (Clusiaceae) on the cognitive function and the induction of oxidative stress in both frontal cortex and hippocampus by unpredictable chronic mild stress (UCMS). By using behavioral mouse models, i.e., the Y-maze test, the Novel Object Recognition Test (NORT), and the Morris Water Maze Test (MWMT), it was found that the negative impact of repeated mild stress-induced learning and memory deficit through brain oxidative stress in the UCMS mice was reversed by treatment with the bark resin e

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Mohamed, Gamal A., and Sabrin R. M. Ibrahim. "Garcixanthone E and Garcimangophenone C: New Metabolites from Garcinia mangostana and Their Cytotoxic and Alpha Amylase Inhibitory Potential." Life 12, no. 11 (2022): 1875. http://dx.doi.org/10.3390/life12111875.

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Garcinia mangostana (Clusiaceae) is a rich pool of metabolites with diversified bioactivities. A new xanthone, garcixanthone E (1), and a new benzophenone, rhamnoside, as well as garcimangophenone C (9) together with garcinone E (2), α-mangostin (3), γ-mangostin (4), garcinone C (5), garcixanthone C (6), gartanin (7), and 2,4,6,3′,5′-pentahydroxybenzophenone (8) were purified from G. mangostana EtOAc extract. Their structural verification was accomplished utilizing assorted spectral tools and relating to the literature. The in vitro cytotoxic potential versus MCF-7, A549, and HCT-116 cell line

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Cahyana, Antonius Herry, Widajanti Wibowo, and Iman Abdullah. "Prenylation of Xanthone Extract from Mangosteen (Garcinia mangostana L.) Rind by Using Superbase Catalyst of g-Alumina/NaOH/Na and Antioxidant Activity Test." Asian Journal of Chemistry 27, no. 6 (2015): 2228–30. http://dx.doi.org/10.14233/ajchem.2015.18588.

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Yahyazadeh, Roghayeh, Vafa Baradaran Rahimi, Ahmad Yahyazadeh, and Vahid Reza Askari. "A Mechanistic Review on Protective Effects of Mangosteen and its Xanthones Against Hazardous Materials and Toxins." Current Neuropharmacology 22 (March 14, 2024). http://dx.doi.org/10.2174/1570159x22666240212142655.

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Abstract: Due to its pharmacological properties, α-Mangostin, mainly found in Garcinia mangostana (G.mangostana) L. (Mangosteen, queen of fruits), treats wounds, skin infections, and many other disorders. In fact, α-Mangostin and other xanthonoid, including β-Mangostin and γ-Mangostin, are found in G. mangostana, which have various advantages, namely neuroprotective, anti-proliferative, antinociceptive, antioxidant, pro-apoptotic, anti-obesity, anti-inflammatory, and hypoglycemic through multiple signaling mechanisms, for instance, extracellular signal-regulated kinase1/2 (ERK 1/2), mitogen-ac

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Choodej, Siwattra, Kedkarn Koopklang, Achara Raksat, Natthaya Chuaypen, and Khanitha Pudhom. "Bioactive xanthones, benzophenones and biphenyls from mangosteen root with potential anti-migration against hepatocellular carcinoma cells." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-12507-8.

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AbstractLiver cancer refers primarily to hepatocellular carcinoma (HCC) accounting for over 90% of cases and is the highest incidence in men in Thailand. Over the past decades, the incidence of HCC dramatically increased with a strong rise of mortality rates. Garcinia mangostana, “Queen of Fruit” of Thailand, is known as a rich source of xanthones with potent cytotoxic properties against various cancer cells. Study on xanthones is provoking not only due to the structural diversity but also a wide variety of pharmacological activities. Hence the aim of the current study is to determine the effe

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W., Ratwita, Sukandar E. Y., Adnyana I. K., and Kurniati N. F. "Alpha Mangostin and Xanthone from Mangosteen (Garcinia mangostana l.) Role on Glucose Tolerance and Glucose Transporter-4 in Diabetes Mellitus." International Journal of Pharmacognosy and Phytochemical Research 9, no. 09 (2017). http://dx.doi.org/10.25258/phyto.v9i09.10307.

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Objective: This research elaborated role of alpha mangostin and xanthone on glucose tolerance and Glucose Transporter (GLUT)-4 by measuring blood glucose level and GLUT-4 expression on cardiac cell musce and adipocyte cell culture. Methods: Glucose tolerance test were conducted using male wistar rat divided into 9 groups, which were normal, control (D-Glucose induced only), glibenclamide, various doses of -mangostin and xanthone (5, 10, 20 mg/kgbw). All group induced by D-glucose 3 g/kg orally 30 minutes later. Blood glucose levels changes were observed at 90th and 150th minute. GLUT-4 study

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Permata, Putri, Retno Kawuri, and AA Ketut Darmadi. "UJI AKTIFITAS ANTIBAKTERI EKSTRAK ETANOL KULIT BUAH MANGGIS (Gracinia mangostana L.) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli." SIMBIOSIS, March 29, 2018, 7. http://dx.doi.org/10.24843/jsimbiosis.2018.v06.i01.p02.

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Mangosteen rind has a benefical compounds liked xanthone which consisting of mangostin, mangosterol, mangostinon A and B, trapezifolixanthone, tovophyllin B, alpha and beta mangostin, garcinon B, mangostanol, gartanin, and flavonoid epikatekin that known contain an antibacterial and antidiare agent. Escherichia coliis an opportunistic bacterium that is commonly found in the human colon as a normal flora. Its unique because it can cause primary infection in the intestine such as diarrhea in children, as well as its ability to cause infection in other body tissues outside the intestine.This rese

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Khaw, Kooi Yeong, Yong Sze Ong та Bey-Hing Goh. "A Rapid Method for the Retrieval of Bioactive Xanthone from Garcinia Mangostana: A Case Study of α-Mangostin". Progress in Drug Discovery & Biomedical Science 3, № 1 (2020). http://dx.doi.org/10.36877/pddbs.a0000072.

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Natural products have been used as the functional food and alternative treatment to combat various diseases for centuries. A handful of bioactive compounds that are available clinically such as antibiotic, anti-neurodegeneration, and anticancer drugs were derived from natural products. Recent study showed that α-mangostin, a natural occurring prenylated xanthone, possesses a wide variety of pharmacological activities including anti-cancer, anti-inflammation, anti-bacterial, anti-viral, and anti-neurodegenerative. In view of the pharmacological importance of α-mangostin, a rapid extraction meth

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Merin, Kenny James. "Preliminary Acute Toxicological Analysis and Profiling of a Commercially Available Mangosteen (Garcinia mangostana) Xanthone Capsule." UIC Research Journal 19, no. 1 (2016). http://dx.doi.org/10.17158/487.

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<p>Mangosteen is known for its wide variety of healing properties, but studies on its toxicity remained insufficient. Toxicological profile of commercially available Garcinia mangostana xanthone capsule was evaluated using a true experimental research design. Acute oral toxicity and toxicant category were employed. After the test animal was administered with xanthone capsule, biomarker such as Alanine Transaminase (ALT), Serum Glutamic Pyruvate Transaminase (SGPT), Blood Urea Nitrogen (BUN) and Serum Creatinine levels were evaluated using the Swiss albino mice. Histopathological (liver a

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Chew, Yik-Ling, Sze-Huey Sang, Gabriel Akyirem Akuwoah та Kai-Bin Liew. "Garcinia mangostana Pericarp Extracts and α-Mangostin in Hair Care: An Insight into Their Potential as Functional Ingredients and the Biological Properties". Natural Products Journal 13 (20 грудня 2022). http://dx.doi.org/10.2174/2210315513666221220092948.

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Abstract: Haircare products with botanical origins and the absence of highly allergenic chemicals, such as parabens, petrochemicals, and silicones, have been considered more skin-friendly and eco-friendly to the environment. Recently, there has been a growing demand for these natural hair care products. Besides the perceived health benefits, many users also believe these botanical origin ingredients are generally milder, non-toxic, natural, and less likely to disrupt the hair and scalp's natural pH and oil balance. Garcinia mangostana has been known for centuries in traditional Asian medicine.

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Seesom, Weeranuch, Amornmart Jaratrungtawee, Sunit Suksamrarn, Chantana Mekseepralard, Piniti Ratananukul, and Wasana Sukhumsirichart. "Antileptospiral activity of xanthones from Garcinia mangostanaand synergy of gamma-mangostin with penicillin G." BMC Complementary and Alternative Medicine 13, no. 1 (2013). http://dx.doi.org/10.1186/1472-6882-13-182.

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Kumaran, Akash, та Prabhu Sukumaran. "Antiurolithiatic Evaluation of α- Mangostin Fraction Isolated from Garcinia mangostana Pericarp through Computational, in vitro and in vivo Approach". Journal of Pharmaceutical Research International, 29 січня 2021, 63–78. http://dx.doi.org/10.9734/jpri/2020/v32i4431082.

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Background: The aqueous crude extract of Garcinia mangostana fruit pericarp was already proven to contain antiurolithiatic property. Based on this previous study the current study was focused on analysing the anti-urolithiatic property of α- mangostin, a xanthone polyphenol isolated from the fruit pericarp of G. manostana, which has not been tested for its anti-urolithiatic property till now. Objective: The aim of this present study is to evaluate the anti-urolithiatic property of the isolated α- mangostin from G. mangostana fruit pericarp using in silico, in vitro and in vivo analysis.&

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Muchtaridi, Muchtaridi, Luthfi Utami Setyawati, Fateen Izzah Haziqah Binti Parlan, Nur Kusaira Khairul Ikram, and Muhammad Yusuf. "Molecular Dynamic Simulation And 3d-Pharmacophore Modeling Of Alpha Mangostin And Its Derivatives Against Estrogen Alpha Receptor." Letters in Drug Design & Discovery 20 (February 20, 2023). http://dx.doi.org/10.2174/1570180820666230220122600.

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Background: Human estrogen receptor alpha (ERα), which is known to play a role in mediating cell proliferation, metastasis, and resistance to apoptosis, is one of the targets of breast cancer therapies. Alpha mangostin (AM) is an active xanthone compound from Garcinia mangostana L. which has activity as an ERα inhibitor. Objectives: This research aims to predict the pharmacokinetic and toxicity and to study the molecular interactions of AM derivatives with the ERα using computer-aided simulation approaches through molecular docking, molecular dynamic, and pharmacophore screening to develop nov

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