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Dissertations / Theses on the topic 'Xenopus laevi'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

MANN, ANJALI. "UNDERSTANDING THE ROLE OF POLQ IN CHROMOSOMAL DNA REPLICATION UNDER STRESSFUL CONDITIONS." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/909725.

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DNA polymerase-theta (Polq) is a class A family DNA polymerase comprising of a helicase-like domain on the N-terminus and a DNA polymerase domain on the C-terminus. Pol-theta overexpression in breast and ovarian cancer patients correlate with high tumor grade and poor response to chemotherapeutic drugs. Consistently, Pol-theta inhibition is synthetically lethal with inactivation of BRCA1/2 genes, which are often found mutated in these tumors. The ability of Pol-theta to sustain viability of BRCA1/2 defective cancer cells has been attributed to its role in alternative end-joining repair of doub

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2

Pan, Tien-Chien Burggren Warren W. "Metabolic, cardiac and ventilatory regulation in early larvae of the South African clawed frog, Xenopus laevis." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/ark:/67531/metadc12175.

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3

Minshull, Jeremy Stephen. "Cynlins in Xenopus laevis." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293835.

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4

Pan, Tien-Chien. "Metabolic, cardiac and ventilatory regulation in early larvae of the South African clawed frog, Xenopus laevis." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc12175/.

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Early development of O2 chemoreception and hypoxic responses under normoxic (150 mmHg) and chronically hypoxic (110 mmHg) conditions were investigated in Xenopus laevis from hatching to 3 weeks post fertilization. Development, growth, O2 consumption, ventilatory and cardiac performance, and branchial neuroepithelial cells (NEC) density and size were determined. At 3 days post fertilization (dpf), larvae started gill ventilation at a rate of 28 ± 4 beats/min and showed increased frequency to 60 ± 2 beats/min at a PO2 of 30 mmHg. Also at 3 dpf, NECs were identified in the gill filament buds u

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5

Tucker, Abigail Saffron. "Tail development in Xenopus laevis." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297296.

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6

Costa, R. "Endoderm patterning in Xenopus laevis." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598012.

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The endoderm is the inner germ layer of the vertebrate embryo from which the respiratory and digestive systems are derived. These include organs such as the liver, pancreas, stomach, lungs and intestine. Recent research has helped our understanding of early vertebrate endoderm specification and terminal differentiation of specific endodermal lineages. However, very little is known about the molecular mechanisms that control endoderm patterning and morphogenesis during vertebrate development. As a way to identify genes involved in these elusive steps of development, I performed a differential h

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7

Marklew, Sarah. "Retinoid receptors in Xenopus laevis." Thesis, University of Warwick, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283494.

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8

Benites, da Costa Ricardo Manuel. "Endodermal patterning in Xenopus laevis." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616152.

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9

Smith, Darrin Paul. "Xenopus laevis octamer-binding proteins." Thesis, University of Warwick, 1990. http://wrap.warwick.ac.uk/108633/.

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The ubiquitous human octamer-binding transcription factor, Oct-1, is believed to regulate the expression of a number of ubiquitously expressed genes. These include genes which are expressed throughout the cell-cycle (eg. snRNA genes) and histone H2B genes, whose expression is tightly coupled to nuclear DNA synthesis at S-phase of the cell-cycle. I have isolated and completely sequenced two X. laevis homologues of Oct-1. The high degree of relatedness of the two homologues indicates that these are likely to be copies of the same gene, which arose during the theoretical genome duplication event

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10

Cleaver, Ondine Beatrice. "Neovascularization of the Xenopus embryo /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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11

Reyes, Hernández Paulina. "Producción de anticuerpos policlonales contra el silenciador de la transcripción del elemento represor (REST) de Xenopus laevis." Tesis, Universidad de Chile, 2005. http://repositorio.uchile.cl/handle/2250/130917.

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Memoria para optar al Título Profesional de Médico Veterinario<br>La regulación transcripcional negativa es un mecanismo importante de control de la expresión de genes que contribuyen en el fenotipo neuronal. El elemento represor de la transcripción REST/NRSF ha sido propuesto como un regulador negativo de muchos genes de diferenciación neuronal terminal, expresándose en células no neuronales, precursores neuronales y neuronas en diferenciación. El papel de REST in vivo durante la diferenciación del sistema nervioso aún se desconoce, dada, entre otras, la letalidad de la pérdida de función de

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12

Cockerill, Matthew James. "D-type cyclins in Xenopus laevis." Thesis, University College London (University of London), 1996. http://discovery.ucl.ac.uk/1349605/.

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I have isolated two D-type cyclins and a putative kinase partner related to Cdk4 from the frog Xenopus laevis. Three D-type cyclins have previously been isolated from mammalian species, where they are thought to be involved in the control of cell proliferation via the regulation the GO-+G 1 and G 1--IS transitions. The RNA and protein levels of D-type cyclins and Cdk4 were followed during Xenopus early embryonic development. The two D-type cyclins and Cdk4 are absent during the early rapid cleavage phase of Xenopus development. Cyclin D1 mRNA and protein can first be detected after the mid-bla

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13

Torres, Monica Alexandra. "WNT signaling pathways in Xenopus laevis /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/6293.

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14

Cardew, Gail. "Studies on Suc1 in Xenopus laevis." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359192.

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15

Glavic, Maurer Álvaro. "Papel del Complejo Iroquois en el Desarrollo Embrionario de Xenopus laevis." Tesis, Universidad de Chile, 2002. http://www.repositorio.uchile.cl/handle/2250/106693.

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16

Moore, Allison Leigh Burrows. "An investigation of xenopus laevis skin amidating enzymes expressed in the baculovirus/insect cell system." Diss., Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/30727.

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17

Powner, Dale John. "Activation of the kexin Krp1 from the fission yeast Schizosaccharomyces pombe." Thesis, University of Warwick, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322480.

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18

Lambert, Thomas. "A role for inhibition in controlling long term responsiveness in young frog tadpoles." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251552.

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19

Wallingford, John Beckett. "Tumor suppressors and oncogenes in the development of Xenopus laevis /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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20

Carroll, Thomas Joseph. "Specification and patterning of the Xenopus laevis pronephros /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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21

Hurter, Etienne. "Biochemical and physiological changes associated with estrogenic activity in Xenopus laevis : a model for the detection of endocrine disruption." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53309.

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Dissertation (PhD)--University of Stellenbosch, 2003.<br>ENGLISH ABSTRACT: Concern has increased that widespread adverse effects are occurring in humans and wildlife populations as a result of exposure to environmental chemicals (mostly man-made) that disrupt the normal functioning of the endocrine system. Many pharmaceutical, agricultural and industrial chemicals, acting as endocrine modulating compounds (EDCs), have been detected in an accumulated form in food, in drinking water and in the environment. Although the levels of these chemicals can be measured analytically, it is important

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22

McKenzie, Andy. "Modelling spiral waves in Xenopus laevis oocyte." Thesis, University of Canterbury. Mathematics and Statistics, 1997. http://hdl.handle.net/10092/6954.

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An investigation was made into the spiral waves solutions for the Atri et al model, a partial differential equation model for Ca²⁺ dynamics in the Xenopus laevis oocyte. Spiral wave solutions, both stable and unstable, were found to exist in the oscillatory regime for this model. The spiral wave solutions were found to have a period that decreased as the initial IP₃ bolus increased. Increasing the initial IP₃ bolus also lead to destabilisation of the spiral waves solutions. After the break up of spiral wave solutions complex spatio-temporal patterns occurred. In some cases spirals reformed aft

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23

Beckhelling, Clare. "Regulation of mitotic progression in Xenopus laevis." Thesis, University of Sussex, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310662.

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24

Porter, Nicola J. "Muscarinic actions in Xenopus laevis tadpole swimming." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/4286.

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Muscarinic acetylcholine receptors (mAChRs) mediate effects of acetylcholine (ACh) in many systems, including those involved in locomotion. In the stage 37/38 Xenopus laevis tadpole, a well-understood model system of vertebrate locomotion, mAChRs have been found to be located on motor neurons with evidence suggesting that mAChRs are involved in swimming behaviour. The current study aimed to further investigate the role of mAChR-mediated cholinergic transmission by employing extracellular and whole-cell patch clamp recordings to examine the effects of mAChR activation on the properties of diffe

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25

Poorten, Thomas J. "Maternal transfer of antibodies in Xenopus laevis." Electronic thesis, 2008. http://dspace.zsr.wfu.edu/jspui/handle/10339/174.

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26

ARRESTA, EMILIANO. "Transdifferenziamento lentogeno e retinogeno in xenopus laevis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2006. http://hdl.handle.net/2108/238.

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SOMMARIO Transdifferenziamento lentogeno Le larve di X. laevis possono rigenerare il cristallino per un processo di transdifferenziamento della cornea esterna in fibre della lente. Tale fenomeno è promosso da un induttore retinico. L’ectoderma corneale deriva dallo strato esterno dell’ectoderma presuntivo lentogeno (PLE) per cui, nelle fasi iniziali dello sviluppo dell’occhio, è interessato dalle azioni induttive che portano alla formazione della lente da parte dello strato profondo del PLE (induzioni precoci). L’induzione della cornea avviene nelle fasi finali dello sviluppo dell’occhi

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27

Woodward, Robert Norman. "Glucocorticoid regulated transcription of the [gamma] fibrinogen subunit gene in xenopus laevis." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9823338.

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28

Fry, William Mark. "K+ channels in Xenopus skeletal muscle /." St. John's NF : [s.n.], 2001.

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29

Morin, Brian L. "The glucocorticoid responsive unit of the xenopus [gamma]fibrinogen gene requires a cooperative interaction between the glucocorticoid receptor and a novel accessory factor." free to MU campus, to others for purchase, 1999. http://wwwlib.umi.com/cr/mo/fullcit?p9953884.

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30

Howe, LeAnn Judith. "Potential roles for chromatin structures in the differential regulation of the 5S rRNA genes in Xenopus laevis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://hdl.handle.net/1828/8294.

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In 1871, a unique substance was isolated from the white blood cells of pus. This substance, which later became known as chromatin, was shown to be a nucleoprotein complex which encompasses the majority of genomic DNA in all eukaryotes. Although chromatin was once viewed as primarily a structural component of the nucleus, it is now accepted that it also plays an important role in the modulation of transcription of individual genes. In this study, the 5S rRNA genes in Xenopus laevis were used as a system to investigate potential roles for chromatin structures in transcription regulation. X. laev

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31

Balanda, Matthew L. "The use of cytoskeletal inhibitors to determine the role of the cytoskeleton in the activation of hypertonicity-induced currents in xenopus oocytes /." View abstract, 1999. http://library.ctstateu.edu/ccsu%5Ftheses/1561.html.

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Thesis (M.A.)--Central Connecticut State University, 1999.<br>Thesis advisor: Kathy Martin. " ... in partial fulfillment of the requirements for the degree of Master of Arts in Biological Sciences." Includes bibliographical references (leaves 42-44).

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32

Newman, Craig Stephen. "The characterization of developmentally regulated homeobox genes in the frog Xenopus laevis /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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33

Duperray, Maëlle. "Rôle des gènes de la voie de biosynthèse des purines au cours du développement embryonnaire de Xenopus laevis." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0750/document.

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La voie de biosynthèse des purines est une voie métabolique conservée et essentielle. Chez l’Homme, des mutations dans plusieurs gènes impliqués dans cette voie provoquent de sévères maladies neuro-musculaires à composante développementale. Cependant, le lien entre génotypes et phénotypes n’est pas connu. Afin de mieux comprendre le rôle des gènes de la voie des purines au cours du développement, nous avons utilisé Xenopus laevis comme modèle vertébré. Les principaux gènes de la voie des purines du xénope n’étaient pas connus, ils ont donc tout d’abord été identifiés in sillico, puis les fonct

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34

Garriock, Robert J. "Mechanisms of heart field restriction in Xenopus laevis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0002/MQ42144.pdf.

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35

Lancaster, Jo-Ann M. "Volume-sensitive membrane transport in Xenopus laevis erythrocytes." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298236.

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36

Thorburn, A. M. "Control of vitellogenin gene expression in Xenopus laevis." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355816.

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37

Farley, Esme Kila. "Immunological tolerance in the amphibian Xenopus laevis (Daudin)." Thesis, University of Plymouth, 1987. http://hdl.handle.net/10026.1/2344.

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Observation of some of the phenomena of tolerance to soluble protein antigens and allogeneic tissue transplants in Xenopus laevis has formed the framework of the present study. The method of larval induction of high-zone tolerance used in this laboratory has been confirmed and further analysed. Larvae treated with high doses of Human-γ-globulin (HGG) were unable to produce anti-HGG antibody after challenge. The proliferative response demonstrated in the spleens of tolerant toadlets 21 days after challenge was, however, of similar magnitude to that in normally responding animals. Adoptive trans

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38

Civill, Nicola Dawn. "Characterisation of a bagpipe homologue in Xenopus laevis." Thesis, University College London (University of London), 2000. http://discovery.ucl.ac.uk/1348859/.

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Mutations of Drosophila bagpipe, an NK3 class homeobox gene, result in failure of visceral mesoderm to differentiate into stomach tissue. Thus bagpipe, in association with other factors, is a good candidate for specification of visceral mesoderm in Drosophila. The cloning and characterisation of a Xenopus bagpipe homologue was therefore of great interest. This study describes the isolation of a full length Xenopus cDNA clone that on the basis of database analysis and sequence comparisons has been assigned as Xenopus bagpipe (XBap). Previous studies had revealed that the majority of homeoprotei

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39

Hough, Katherine Ann. "Photodispersion and melanopsin expression in Xenopus laevis melanophores." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416960.

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40

Hopwood, N. D. "Molecular markers of mesoderm induction in Xenopus laevis." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317830.

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41

Schulze, Sabrine. "Wnt6 function in eye development in Xenopus laevis." Thesis, University of Aberdeen, 2012. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=192239.

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The eyes are the most important sensory organs for most vertebrates. Their structure and development is conserved between several vertebrate species. The development is regulated by several signalling pathways, including the Wnt/β-catenin signalling pathway. It is required for several aspects of retinal development and it is known to regulate the proliferation of neuro-epithelial stem cells. In Xenopus laevis the intracellular Wnt/β-catenin signalling pathway is activated in the retina by the Wnt receptor Fz5. Fz5 function in the eye was shown to regulate tissue specific gene expression and ne

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42

Cesare, Gargioli. "Cell lineage tracing during Xenopus laevis tail regeneration." Thesis, University of Bath, 2005. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425270.

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43

Chalmers, Andrew Douglas. "Development of the endodermal organs in Xenopus laevis." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302152.

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44

Ferreira, Ana Catarina Oliveira. "Estrutura etária e crescimento das populações invasoras da rã Xenopus laevis em Portugal: um estudo esqueletocronológico." Master's thesis, Universidade de Évora, 2014. http://hdl.handle.net/10174/12122.

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Há duas populações invasoras da rã Xenopus laevis em Portugal, nas ribeiras da Laje e de Barcarena, em Oeiras. Aparentemente essas duas populações estão isoladas entre si. Estudou-se a documentada diferença de tamanhos das rãs entre as duas ribeiras, usando a esqueletocronologia para avaliar a estrutura etária, longevidade e crescimento delas. A população da ribª da Laje está envelhecida, pois as rãs apresentam maiores valores de tamanho corporal, idade e maturação sexual mais tardia nas fêmeas. Na ribª de Barcarena há uma estrutura etária jovem, com valores menores de tamanho e idade. Isto su

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45

Vollmar, Friederike Lara Veronika. "Analyse der Kernhüllenbildung am Modellsystem Xenopus laevis = Studying nuclear envelope assembly in the cell-free system derived from Xenopus laevis eggs." kostenfrei, 2008. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2009/2929/.

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46

Ford, Rebecca. "Gene expression analysis of Xrel3-induced tumours in Xenopus laevis /." St. John's, NF : [s.n.], 2000.

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47

Frazzetto, Giovanni. "Xmc, a novel Xenopus laevis organiser : gene regulating gastrulation movements." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268764.

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48

Héligon, Christophe. "Wnt/frizzled signaling during Xenopus laevis pronephric kidney organogenesis /." Zürich : ETH, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17287.

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49

Hamm, Lisa. "Controlled ablation of rod photoreceptors in transgenic Xenopus laevis." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/236.

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Retinal degeneration is the progressive loss of neurons lining the posterior surface of the eye. Loss of a certain group of neurons called rod photoreceptors can occur as the result of genetic mutation. In humans, and in mammalian models of retinal degeneration, the death of these cells is permanent, and often followed by cone photoreceptor death, which leads to blindness. As a step towards understanding the implications of rod cell death in the retina, we generated transgenic X. laevis that expressed a novel form of caspase-9, with binding domains specific to the compound AP20187. We treate

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50

Feng, Jun. "A kinetic investigation of recombinant xenopus laevis amidating enzymes." Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/30084.

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