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Journal articles on the topic 'Xing wei sheng'

Author: Grafiati

Published: 13 December 2022

Last updated: 31 July 2025

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1

Hu, Ben, Lei-Ping Zeng, Xing-Lou Yang, et al. "Discovery of a rich gene pool of bat SARSrelated coronaviruses provides new insights into the origin of SARS coronavirus." PLoS Pathogens 13, no. 11 (2017): 1–27. https://doi.org/10.1371/ journal.ppat.1006698.

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Hu, Ben, Zeng, Lei-Ping, Yang, Xing-Lou, Ge, Xing-Yi, Zhang, Wei, Li, Bei, Shen, Xu-Rui, Zhang, Yun-Zhi, Wang, Ning, Luo, Dong-Sheng, Zheng, Xiao- Shuang, Wang, Mei-Niang, Daszak, Peter, Wang, Lin-Fa, Cui, Jie, Shi, Zheng- Li (2017): Discovery of a rich gene pool of bat SARSrelated coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathogens 13 (11), No. 1006698: 1-27, DOI: 10.1371/journal.ppat.1006698

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Yin, Hai-Xiang, Wei-Xing Shen, and Zhan Yin. "--A--new--species--and--a--key--to--10--species--of--the--genus Lemba--Huang,--1983--(Orthoptera Catantopidae)--from--China--." Zootaxa 4894, no. 2 (2020): 287–91. https://doi.org/10.11646/zootaxa.4894.2.8.

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Yin, Hai-Xiang, Shen, Wei-Xing, Yin, Zhan (2020): --A--new--species--and--a--key--to--10--species--of--the--genus Lemba--Huang,--1983--(Orthoptera Catantopidae)--from--China--. Zootaxa 4894 (2): 287-291, DOI: 10.11646/zootaxa.4894.2.8

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3

Gao, Yue, Chun-Jie Liu, Hua-Yi Li, et al. "Abstract LB168: Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study." Cancer Research 82, no. 12_Supplement (2022): LB168. http://dx.doi.org/10.1158/1538-7445.am2022-lb168.

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Abstract Background: Morpho-physiological alternations of platelets provided a rationale to harness RNA sequencing of tumor-educated platelets (TEPs) for preoperative diagnosis of cancer. Timely, accurate, and non-invasive detection of ovarian cancer in women with adnexal masses presents a significant clinical challenge. Patients and Methods: This intercontinental, hospital-based, diagnostic study included 761 treatment-naïve inpatients with histologically confirmed adnexal masses and 167 healthy controls from nine medical centers (China, n=3; Netherlands, n=5; Poland, n=1) between September 2

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Төрбат, Цагаан. "Ашина овгийн хатны эртний геном нь Хөх түрэгийн хаант улсыг Зүүн хойд Азийн гаралтай болохыг харуулжээ". Mongolian Journal of Anthropology, Archaeology and Ethnology 13, № 1 (2024): 141–45. http://dx.doi.org/10.22353/mjaae.20241301013.

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Xiao‐Min Yang, Hai‐Liang Meng, Jian‐Lin Zhang, Yao Yu, Edward Allen, Zi‐Yang Xia, Kong‐Yang Zhu, Pan‐Xin Du, Xiao‐Ying Ren, Jian‐Xue Xiong, Xiao‐Yu Lu, Yi Ding, Sheng Han, Wei‐Peng Liu, Li Jin, Chuan‐Chao Wang, and Shao‐Qing Wen. Ancient genome of Empress Ashina reveals the Northeast Asian origin of Göktürk Khanate. – Journal of Systematic and Evolution. Institute of Botany, Chinese Academy of Sciences. 2023. Volume 00 (0) 1-9.

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Yang, Wei-Cheng, and Xiang-Sheng Chen. "New substitute name for the genus Mistaria Medler, 1988 (Hemiptera: Fulgoromorpha: Flatidae)." Zootaxa 3956, no. 3 (2015): 449–50. https://doi.org/10.11646/zootaxa.3956.3.11.

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6

Erst, Andrey S., Wei Wang, Sheng-Xiang Yu, et al. "Two new species and four new records of Aquilegia (Ranunculaceae) from China." Phytotaxa 316, no. 2 (2017): 121–37. https://doi.org/10.11646/phytotaxa.316.2.2.

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Erst, Andrey S., Wang, Wei, Yu, Sheng-Xiang, Xiang, Kunli, Wang, Jian, Shaulo, Dmitry N., Smirnov, Sergey V., Kushunina, Maria, Sukhorukov, Alexander P., Nobis, Marcin (2017): Two new species and four new records of Aquilegia (Ranunculaceae) from China. Phytotaxa 316 (2): 121-137, DOI: 10.11646/phytotaxa.316.2.2, URL: http://dx.doi.org/10.11646/phytotaxa.316.2.2

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Shen, Wei-Xing, Chun-Yan Jia, and Zhan Yin. "A new species of the genus Mongolotettix Rehn, 1928 from Shandong, China (Acrididae, Acridoidea, Orthoptera)." Zootaxa 5125, no. 1 (2022): 97–100. https://doi.org/10.11646/zootaxa.5125.1.7.

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Shen, Wei-Xing, Jia, Chun-Yan, Yin, Zhan (2022): A new species of the genus Mongolotettix Rehn, 1928 from Shandong, China (Acrididae, Acridoidea, Orthoptera). Zootaxa 5125 (1): 97-100, DOI: 10.11646/zootaxa.5125.1.7

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Meng, Xiang-Wei, Zhi-Sheng Zhang, and Ai-Ming Shi. "Description of two unknown females of Epeus Peckham & Peckham from China (Araneae: Salticidae)." Zootaxa 3955, no. 1 (2015): 147–50. https://doi.org/10.11646/zootaxa.3955.1.11.

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Meng, Xiang-Wei, Zhang, Zhi-Sheng, Shi, Ai-Ming (2015): Description of two unknown females of Epeus Peckham & Peckham from China (Araneae: Salticidae). Zootaxa 3955 (1): 147-150, DOI: 10.11646/zootaxa.3955.1.11

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9

Wu, Chun-Yan, Yang Liao, Zi-Gang Yang, et al. "Cytotoxic diterpenoids from Salvia yunnanensis." Phytochemistry 106 (October 31, 2014): 171–77. https://doi.org/10.1016/j.phytochem.2014.07.001.

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Wu, Chun-Yan, Liao, Yang, Yang, Zi-Gang, Yang, Xing-Wei, Shen, Xiao-Ling, Li, Rong-Tao, Xu, Gang (2014): Cytotoxic diterpenoids from Salvia yunnanensis. Phytochemistry 106: 171-177, DOI: 10.1016/j.phytochem.2014.07.001, URL: http://dx.doi.org/10.1016/j.phytochem.2014.07.001

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10

Ye, Bao-Hua, Wei-Xing Shen, Chun-Yan Jia, and Zhan Yin. "A new species and key to known species of the genus Conophymacris Willemse 1933 (Orthoptera, Acridoidea, Catantopidae, Podisminae) from China." Zootaxa 5047, no. 5 (2021): 583–88. https://doi.org/10.11646/zootaxa.5047.5.8.

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Ye, Bao-Hua, Shen, Wei-Xing, Jia, Chun-Yan, Yin, Zhan (2021): A new species and key to known species of the genus Conophymacris Willemse 1933 (Orthoptera, Acridoidea, Catantopidae, Podisminae) from China. Zootaxa 5047 (5): 583-588, DOI: 10.11646/zootaxa.5047.5.8

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Guo, Hui, Lai Wei, Jia-Chen Hao, Yu-Fen Du, Lin-Jing Zhang, and Sheng-Xiang Yu. "Impatiens occultans (Balsaminaceae), a newly recorded species from Xizang, China, and its phylogenetic position." Phytotaxa 275, no. 1 (2016): 62–68. https://doi.org/10.11646/phytotaxa.275.1.7.

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Guo, Hui, Wei, Lai, Hao, Jia-Chen, Du, Yu-Fen, Zhang, Lin-Jing, Yu, Sheng-Xiang (2016): Impatiens occultans (Balsaminaceae), a newly recorded species from Xizang, China, and its phylogenetic position. Phytotaxa 275 (1): 62-68, DOI: 10.11646/phytotaxa.275.1.7, URL: http://dx.doi.org/10.11646/phytotaxa.275.1.7

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Cao, Liang, Nuzhat Shehla, Bin Li, et al. "Schinortriterpenoids from Tujia ethnomedicine Xuetong-The stems of Kadsura heteroclita." Phytochemistry 169 (January 31, 2020): 1–7. https://doi.org/10.1016/j.phytochem.2019.112178.

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Cao, Liang, Shehla, Nuzhat, Li, Bin, Jian, Yuqing, Peng, Caiyun, Sheng, Wenbing, Liu, Leping, Cai, Xiong, Man, Rongyong, Liao, Duan-Fang, Choudhary, M. Iqbal, Rahman, Atta-ur, Wang, Wei (2020): Schinortriterpenoids from Tujia ethnomedicine Xuetong-The stems of Kadsura heteroclita. Phytochemistry (112178) 169: 1-7, DOI: 10.1016/j.phytochem.2019.112178, URL: http://dx.doi.org/10.1016/j.phytochem.2019.112178

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13

Dai, Xin, Ling-Yu Zhou, Jie-Xia Cao, et al. "Effect of Group Density on the Physiology and Aggressive Behavior of Male Brandt's Voles (Lasiopodomys brandtii)." Zoological Studies 57, no. 35 (2018): 1–11. https://doi.org/10.6620/ZS.2018.57-35.

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Dai, Xin, Zhou, Ling-Yu, Cao, Jie-Xia, Zhang, Yan-Qi, Yang, Feng-Ping, Wang, Ai-Qin, Wei, Wan-Hong, Yang, Sheng-Mei (2018): Effect of Group Density on the Physiology and Aggressive Behavior of Male Brandt's Voles (Lasiopodomys brandtii). Zoological Studies 57 (35): 1-11, DOI: 10.6620/ZS.2018.57-35

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14

Huang, Ting, Sheng-Hui Ying, Jing-Ya Li, et al. "Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis." Phytochemistry 169 (January 31, 2020): 1–14. https://doi.org/10.1016/j.phytochem.2019.112184.

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Huang, Ting, Ying, Sheng-Hui, Li, Jing-Ya, Chen, Hao-Wei, Zang, Yi, Wang, Wen-Xuan, Li, Jia, Xiong, Juan, Hu, Jin-Feng (2020): Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis. Phytochemistry (112184) 169: 1-14, DOI: 10.1016/j.phytochem.2019.112184, URL: http://dx.doi.org/10.1016/j.phytochem.2019.112184

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15

Zhang, Ming, Tai-Hui Li, Tie-Zheng Wei, Xi-Shen Liang, and Zhu-Xiang Liu. "Ripartitella brunnea, a new species from subtropical China." Phytotaxa 387, no. 3 (2019): 255–61. https://doi.org/10.11646/phytotaxa.387.3.6.

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Zhang, Ming, Li, Tai-Hui, Wei, Tie-Zheng, Liang, Xi-Shen, Liu, Zhu-Xiang (2019): Ripartitella brunnea, a new species from subtropical China. Phytotaxa 387 (3): 255-261, DOI: 10.11646/phytotaxa.387.3.6, URL: http://dx.doi.org/10.11646/phytotaxa.387.3.6

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16

Zhang, Wei, Guang-Xia Shang, J. Patrick Kociolek, Li-Qing Wang, and Hong-Xin Tan. "Gomphonema bicepiformis sp. nov., a new diatom species (Bacillariophyta) from a stream in Zhejiang, China." Phytotaxa 375, no. 4 (2018): 274–82. https://doi.org/10.11646/phytotaxa.375.4.3.

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Zhang, Wei, Shang, Guang-Xia, Kociolek, J. Patrick, Wang, Li-Qing, Tan, Hong-Xin (2018): Gomphonema bicepiformis sp. nov., a new diatom species (Bacillariophyta) from a stream in Zhejiang, China. Phytotaxa 375 (4): 274-282, DOI: 10.11646/phytotaxa.375.4.3, URL: http://dx.doi.org/10.11646/phytotaxa.375.4.3

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17

Lim, Lionel Jian Wei, Joseph Boon Yeow Loh, Aloysius Jin Shen Lim, et al. "Diversity and distribution of intertidal marine species in Singapore." Raffles Bulletin of Zoology 68 (May 22, 2020): 396–403. https://doi.org/10.26107/RBZ-2020-0056.

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Lim, Lionel Jian Wei, Loh, Joseph Boon Yeow, Lim, Aloysius Jin Shen, Tan, Beryl Ying Xin, Ip, Yin Cheong Aden, Neo, Mei Lin, Tan, Ria, Huang, Danwei (2020): Diversity and distribution of intertidal marine species in Singapore. Raffles Bulletin of Zoology 68: 396-403, DOI: 10.26107/RBZ-2020-0056

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18

Wei, Kun, Zhi-He Zhang, Wen-Ping Zhang, et al. "Sequence variation of mitochondrial DNA ND5 in captive South China tigers (Panthera tigris amoyensis)." Journal of Natural History 39, no. 46 (2005): 3979–84. https://doi.org/10.1080/00222930600579031.

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Wei, Kun, Zhang, Zhi-He, Zhang, Wen-Ping, Shen, Fu-Jun, He, Guang-Xin, Hou, Rong, Xie, Zhong, Liu, Nong-Lin, Yue, Bi-Song (2005): Sequence variation of mitochondrial DNA ND5 in captive South China tigers (Panthera tigris amoyensis). Journal of Natural History 39 (46): 3979-3984, DOI: 10.1080/00222930600579031, URL: http://dx.doi.org/10.1080/00222930600579031

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19

김지영. "A Study on the Evaluation of the Wu Wei-ye and Zha Shen-xing Poetry represented in ≪Oubeishihua≫." Journal of Chinese Language and Literature ll, no. 76 (2017): 197–228. http://dx.doi.org/10.15792/clsyn..76.201712.197.

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20

Jhang, Jing-Siang, Hanoch Livneh, Shu-Yi Yang, et al. "Decreased risk of colorectal cancer among patients with type 2 diabetes receiving Chinese herbal medicine: a population-based cohort study." BMJ Open Diabetes Research & Care 8, no. 1 (2020): e000732. http://dx.doi.org/10.1136/bmjdrc-2019-000732.

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ObjectivesPatients with type 2 diabetes have a higher risk of colorectal cancer (CRC), but whether Chinese herbal medicines (CHMs) can reduce this risk is unknown. This study investigated the effect that CHMs have on CRC risk in patients with type 2 diabetes.Research design and methodsThis cohort study used the Taiwanese National Health Insurance Research Database to identify 54 744 patients, newly diagnosed with type 2 diabetes, aged 20–70 years, who were receiving treatment between 1998 and 2007. From this sample, we randomly selected 14 940 CHMs users and 14 940 non-CHMs users, using propen

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21

Kim, Baik-Gyun. "Self-Consciousness of Wen (文) in Wei-Jin and North-South Dynasties and The Semantic Expansion of Xing (興) and Shen (神)". Journal of Aesthetics & Science of Art 67 (31 жовтня 2022): 60–81. http://dx.doi.org/10.17527/jasa.67.0.03.

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22

Wang, Jie, and Xingjiang Xiong. "Control Strategy on Hypertension in Chinese Medicine." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/284847.

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Hypertension is a clinical common disease, with high mortality and disability. Although there have also been significant advances in therapeutic concepts and measures, it has shown a certain value and significance in the treatment of Chinese medicine. The control strategy on hypertension is described from the following aspects such as differentiation of symptoms, pathogenesis, formula syndrome, and herb syndrome. As the common clinical manifestations of hypertension are dizziness, headache, fatigue, lassitude in the loins and knees, and so on, the pathogeneses of them are analysed. The author

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23

Xu, Chang, Kie Kyon Huang, Jia Hao Law, et al. "Abstract P28: Comprehensive Molecular Phenotyping of ARID1A-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities." Cancer Research 84, no. 8_Supplement (2024): P28. http://dx.doi.org/10.1158/1538-7445.fcs2023-p28.

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Abstract Objective Gastric cancer (GC) is a leading cause of cancer mortality, with ARID1A being the second most frequently mutated driver gene in GC. We sought to decipher ARID1A-specific GC regulatory networks and examine therapeutic vulnerabilities arising from ARID1A loss. Design Genomic profiling of GC patients including a Singapore cohort (&gt;200 patients) was performed to derive mutational signatures of ARID1A inactivation across molecular subtypes. Single-cell transcriptomic profiles of ARID1A-mutated GCs were analyzed to examine tumor microenvironmental changes arising from ARID1

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Artiushin, S., J. F. Timoney, J. Nally, and A. Verma. "Host-Inducible Immunogenic Sphingomyelinase-Like Protein, Lk73.5, of Leptospira interrogans." Infection and Immunity 72, no. 2 (2004): 742–49. http://dx.doi.org/10.1128/iai.72.2.742-749.2004.

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ABSTRACT Leptospira interrogans causes a variety of clinical syndromes in animals and humans. Although much information has accumulated on the importance of leptospiral lipopolysaccharide in protective antibody responses, relatively little is known about proteins that participate in immune responses. Identification of those proteins induced only in the host is particularly difficult. Using a novel double-antibody screen designed to identify clones in a gene library of L. interrogans serovar Pomona expressing host-inducible proteins, we have characterized a gene (lk75.3) encoding a sphingomyeli

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25

Wang, Mei-Hui. "Xiaolin: Un'esplorazione su barzellette e umorismo nella cultura cinese antica." Traduction et Langues 23, no. 2 (2024): 209–32. http://dx.doi.org/10.52919/translang.v23i2.1003.

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Xiaolin: An Exploration of Jokes and Humor in Ancient Chinese Culture This article is based on the study of the book "Xiaolin" (The Forest of Laughter) by Handan Chun 邯鄲淳 (ca.132-ca.221) of the Cao Wei 曹魏 period in the Eastern Han Dynasty 東漢 (25-220).The first book dedicated to jokes in ancient China. The realistic and satirical folk stories produced against the backdrop of the times, reflected the interest in life, humor and the educational sense of the literati, lower-class and common peopleof that period (Wang, 1981; Huang, 1999). Focusing on the only 29 jokes left in the book, the extracts

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Yeo, Shen Yong, Wai Yee Wong, Jesslyn, Tan Boon Toh, Valerie Shiwen Yang, and Xing Yi Woo. "Abstract P58: Utilizing Cancer Vulnerabilities and Dependencies to Explore Cancer Biomarkers by Triangulating Large-Scale Gene Knockout and Drug Response Data." Cancer Research 84, no. 8_Supplement (2024): P58. http://dx.doi.org/10.1158/1538-7445.fcs2023-p58.

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Abstract The identification of biomarkers of therapeutic response for different cancers presents significant challenges owing to the heterogeneity of these diseases. Whole-genome CRISPR gene knockout screening (DepMap) and large-scale drug dosing (e.g. PRISM, and Sanger GDSC) performed across large panels of cancer cell lines reveal a whole spectrum of cancer vulnerabilities and dependencies that can be used to identify potential biomarkers and perturbed pathways in subtypes of cancers. In this study, we identified tumor type-specific dependent genes with CRISPR screening data. Functional rela

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Sheshadri, Namratha, Rongrong Li, Muhammad Usama Tariq, et al. "Abstract PO-035: Genome-wide CRISPR knockout screen identifies sialylation as a tumor suppressive mechanism in B-cell malignancies." Blood Cancer Discovery 5, no. 3_Supplement (2024): PO—035—PO—035. http://dx.doi.org/10.1158/2643-3249.lymphoma24-po-035.

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Abstract Ba/F3 is a murine pro-B cell line that is dependent on interleukin-3 (IL-3) for its survival and proliferation. It has been widely used for identifying oncogenes and mechanisms of drug-resistance. Using this cell line, we conducted a genome-wide CRISPR knockout screen to identify genes whose loss can confer IL-3 independence, hence may be implied as tumor suppressor genes (TSGs). We identified several genes that map to human chromosome 6q, a frequent deletion hotspot in B-cell malignancies, that may act as TSGs. One of these putative novel TSGs is Slc35a1, which encodes the membrane s

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Dong, Wenjuan, Xin Wang, Kun Han, et al. "Abstract PO2-27-07: The Role of HCMV Infection in Facilitating Brain Metastasis through the Creation of a Suppressive Tumor Microenvironment in Breast Cancer Patients." Cancer Research 84, no. 9_Supplement (2024): PO2–27–07—PO2–27–07. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-27-07.

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Abstract Human Cytomegalovirus (HCMV) infection has emerged as a noteworthy factor in breast cancer patients, particularly those experiencing brain metastasis. Despite being prevalent and often asymptomatic, HCMV's contribution to tumor progression remains enigmatic. Notably, a high proportion of breast cancer patients with brain metastasis exhibit HCMV positivity in both primary tumors and metastatic lesions. This study aims to elucidate the influence of HCMV infection on brain metastasis by investigating its impact on the tumor microenvironment. Our findings reveal a distinctive immune suppr

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Liu, Fan, and Bangcai Wang. "Die klinische Anwendung von Li Dongyuans Grundsatz „Regulieren der oo. lienalis et stomachi (Fk ‚Milz‘ und ‚Magen“, pi wei) durch Beruhigen und Nähren des o. cardialis (Fk ‚Herz‘, xin) und der konstellierenden Kraft shen“." Chinesische Medizin / Chinese Medicine 29, no. 2 (2014): 79–89. http://dx.doi.org/10.1007/s00052-014-0025-8.

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Tariq, Muhammad Usama, Julia Shen, Jaeyong Jung, et al. "Abstract PO-019: Ubiquitin E3 ligase OSTM1 regulates the cAMP/PKA/CREB pathway and suppresses B-cell malignancies." Blood Cancer Discovery 5, no. 3_Supplement (2024): PO—019—PO—019. http://dx.doi.org/10.1158/2643-3249.lymphoma24-po-019.

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Abstract B-cell malignancies (BCM) often arise from genomic alterations introduced during different stages of B-cell development. Here, we performed a whole genome targeting CRISPR/Cas9 screen in the immortalized yet non-transformed IL-3-dependent Ba/F3 murine pro-B cell line to identify genes whose loss confers IL-3 independence, reasoning that these genes may function as tumor suppressor genes (TSGs) in BCM. One of the candidate genes is osteoporosis-associated transmembrane protein 1 (OSTM1), an E3 ubiquitin ligase whose loss-of-function causes autosomal recessive osteoporosis. Informatics

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Mao, Mao, Bing Wei, Qingxia Xu, et al. "Abstract 1269: Large-scale validaton studies of a blood-based effective and affordable test for multicancer early detection." Cancer Research 84, no. 6_Supplement (2024): 1269. http://dx.doi.org/10.1158/1538-7445.am2024-1269.

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Abstract Cancer early detection aims at reducing cancer deaths. Unfortunately, many established cancer screening methods are not suitable for use in low- and middle-income countries (LMICs) due to cost, complexity, and dependency on extensive medical infrastructure. Nearly 10,000 participants (2003 cancer cases and 7888 non-cancer cases) were divided into one training and five independent validation cohorts across different races, sample types and platforms. One tube of peripheral blood was collected from each participant and quantified using a panel of seven protein tumor markers (PTMs) consi

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Zhang, Jie, Feng Gao, Wei Zhu, et al. "Abstract 5727: ISM9682A, a novel and potent KIF18A inhibitor, shows robust antitumor effects against chromosomally unstable cancers." Cancer Research 84, no. 6_Supplement (2024): 5727. http://dx.doi.org/10.1158/1538-7445.am2024-5727.

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Abstract KIF18A belongs to the kinesin-8 subfamily and is a plus-end-directed motor, which regulates kinetochore microtubules dynamics to control mitotic chromosome alignment and spindle tension. Studies have shown that genetic depletion or pharmacological inhibition of KIF18A is a promising therapeutic approach for cancers, exhibiting high chromosomal instability (CIN-high), without having a significant impact on the normal division of euploid cells. Here, we report the discovery and preclinical evaluation of ISM9682A, a novel KIF18A inhibitor with excellent potency and high selectivity. ISM9

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Li, Ziming, Xiaomin Dang, Dingzhi Huang, et al. "Abstract CT246: Open-label, single-arm, multicenter, phase 2 trial of garsorasib in KRAS G12C-mutated non-small-cell lung cancer." Cancer Research 84, no. 7_Supplement (2024): CT246. http://dx.doi.org/10.1158/1538-7445.am2024-ct246.

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Abstract Background: Garsorasib (D-1553), a potent KRAS G12C inhibitor, has previously demonstrated promising anti-tumor activity in KRAS G12C-mutated non-small-cell lung cancer (NSCLC) in a phase 1 study. Here we present the efficacy and safety of garsorasib in a pivotal phase 2 study. Methods: In this open-label, multicenter, single-arm phase 2 study, patients received garsorasib 600 mg twice daily in 21-day cycles. Eligible criteria included patients with locally advanced or metastatic NSCLC harboring KRAS G12C mutation, who had disease progression after prior anti-PD-(L)1 therapy and plati

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Cheng, Ying, Lin Shen, Zhendong Chen, et al. "Abstract CT225: Surufatinib plus toripalimab for first-line treatment of advanced non-small cell lung cancer (NSCLC) with PD-L1 positive expression: A multicenter, single-arm phase 2 study." Cancer Research 83, no. 8_Supplement (2023): CT225. http://dx.doi.org/10.1158/1538-7445.am2023-ct225.

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Abstract Background: Surufatinib (S, a small-molecule inhibitor of VEGFR 1-3, FGFR1 and CSF-1R) plus toripalimab (T, an anti-PD-1 antibody) showed encouraging antitumor activity in solid tumors (Cao YS, 2022). Programmed death ligand 1 (PD-L1) expression is the established biomarker for 1L immune checkpoint inhibitors therapy in advanced NSCLC. We conducted an open-label, multi-cohort, single-arm phase 2 study to evaluate the safety and efficacy of S+T in patients (pts) with advanced solid tumors. Here, we reported the results of advanced NSCLC with PD-L1 positive expression cohort. Methods: E

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Li, Rongrong, Namratha Sheshadri, Jianliang Shen, et al. "Abstract PO-020: ZBTB24 is a novel tumor suppressor and cooperates with CDKN2A to suppress B-cell lymphomagenesis." Blood Cancer Discovery 5, no. 3_Supplement (2024): PO—020—PO—020. http://dx.doi.org/10.1158/2643-3249.lymphoma24-po-020.

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Abstract B-cell lymphoma is the most common hematological malignancy that accounts for the sixth highest mortality among all cancers. Despite recent improvements on combined chemotherapy and immunotherapy, treatments remain challenging due to complex genetic heterogeneity and molecular pathogenesis. To explore novel mechanisms in B-cell lymphomagenesis, we performed a genome-wide CRISPR knockout screen in the murine interleukin-3 (IL-3)-dependent Ba/F3 pro-B cell line and identified Zbtb24 as a putative target whose silencing leads to elevated proliferative signaling and reduced apoptosis, con

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Black, Kathryn, Elena Sotillo, Nicole Martinez, et al. "Regulation of CD19 Exon 2 Inclusion in B-Lymphoid Cells By Splicing Factors and Epigenetic Marks." Blood 126, no. 23 (2015): 2425. http://dx.doi.org/10.1182/blood.v126.23.2425.2425.

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Abstract CD19 is expressed broadly on the surface of B-cells during normal development and malignant growth, making it a good target for immunotherapy. While immunotherapies targeting CD19 have had great success against pediatric B-cell acute lymphoblastic leukemia (B-ALL), relapses lacking the CD19 epitope still occur (Maude et al., 2014). We have discovered that alternative splicing of CD19, in particular the skipping of exon 2, is responsible for the loss of CD19 extracellular domains, causing resistance to therapy (Sotillo et al., 2015). Here we investigate the molecular mechanism of CD19

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Zhong, Haihong (Helen), Yan Xiong, Han Huang, et al. "Abstract 3133: A novel bispecific antibody-drug conjugate targeting HER2 and Trop-2 displays potent antitumor activity in a variety of tumor models with promising preclinical characteristics." Cancer Research 84, no. 6_Supplement (2024): 3133. http://dx.doi.org/10.1158/1538-7445.am2024-3133.

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Abstract Antibody-drug conjugates (ADCs) have exhibited considerable advancements in cancer therapy, though their efficacy is often confined to specific patient subsets or results in modest clinical responses due to low and heterogenous expression of drug targets in tumors. Targeting more than one tumor-associated antigens (TAAs) represents a new strategy to broaden treatment applicability and minimize on-target toxicity of ADC. Our analysis of co-expression of HER2 and Trop-2, two clinically validated ADC targets, in tumors of various histological malignancies manifests the great potential fo

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Hoppe, Michal M., Patrick Jaynes, Shuangyi Fan, et al. "Abstract 5557: Patterns of oncogene co-expression at single cell resolution influence survival in diffuse large B-cell lymphoma." Cancer Research 83, no. 7_Supplement (2023): 5557. http://dx.doi.org/10.1158/1538-7445.am2023-5557.

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Abstract Background: Cancers often overexpress multiple clinically relevant oncogenes. However, it is not known if multiple oncogenes within a cancer combineuniquely in specific cellular sub-populations to influence clinical outcome.We studied this phenomenon using the prognostically relevantoncogenes MYC, BCL2 and BCL6 in Diffuse Large B-Cell Lymphoma(DLBCL). Methods: Quantitative multispectral imaging simultaneously measured oncogene co-expression at single-cell resolution in reactive lymphoid tissue (n=12)and four independent cohorts (n=409) of DLBCL. Mathematically derived co-expression ph

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Zhang, Xu, Marimikel Charrier, and Caroline M. Ajo-Franklin. "Multichannel Bioelectronic Sensing: Binary Encoding of Environmental Contaminants." ECS Meeting Abstracts MA2024-02, no. 64 (2024): 4260. https://doi.org/10.1149/ma2024-02644260mtgabs.

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Environmental water contamination from natural and synthetic chemicals is a pressing global issue. Addressing this requires the development of portable, selective, and accurate sensors. Biosensors, particularly whole-cell bioelectronic sensors, are promising due to their ability to convert chemical signals into electrical signals via extracellular electron transfer (EET) pathways. However, these sensors typically employ a single electron transfer pathway as an electrochemical channel, limiting them to the detection of a single analyte (Atkinson et al. 2022). To expand the information content,

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Wang, Jun-Ling, Hong-Wei Li, Hong-Xia Liu, et al. "Abstract 2108: Comparative analysis of fusion gene detection rates in tissue versus blood samples from Chinese diverse solid tumors." Cancer Research 85, no. 8_Supplement_1 (2025): 2108. https://doi.org/10.1158/1538-7445.am2025-2108.

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Abstract Background: The landscape of genetic alterations, particularly fusion genes, plays a critical role in the diagnosis and treatment of various solid tumors. As liquid biopsy methods evolve, understanding the differences in mutation frequencies between tissue and blood samples becomes essential for precision oncology. This study aimed to evaluate the detection rates of specific fusion genes in both tumor tissue and blood samples from patients with diverse solid tumors using a 733-gene panel through Next-Generation Sequencing (NGS). Methods: We conducted a comprehensive analysis of 23 typ

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Li, Chao, Zhishan Chen, Qing Li, et al. "Abstract 6614: Integrating single-cell RNA-seq and large genome-wide association study data to identify colorectal cancer cell-of-origin populations." Cancer Research 84, no. 6_Supplement (2024): 6614. http://dx.doi.org/10.1158/1538-7445.am2024-6614.

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Abstract Background: Single-cell RNA sequencing (scRNA-seq) enables the precise identification of distinct cell populations and the measurement of gene expression within each population. Recently, integrating scRNA-seq and genome-wide association study (GWAS) data has shown promise in identifying cell-of-origin populations in human diseases. Colorectal cancer (CRC) progresses through a phenotypic continuum from normal colon to adenoma, and ultimately CRC. However, the specific disease cell-of-origin populations underlying each stage of CRC development at a single-cell resolution have not been

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Shang, Qingyao, Ya Wei, Guangdong Qiao, Jingruo Li, and Xin Wang. "Abstract P2-14-22: Evaluation of male breast cancer and the application of sentinel lymph node biopsy: A multi-center retrospective study." Cancer Research 83, no. 5_Supplement (2023): P2–14–22—P2–14–22. http://dx.doi.org/10.1158/1538-7445.sabcs22-p2-14-22.

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Abstract Objective:Sentinel lymph node biopsy (SLNB) is currently used as a routine treatment for breast cancer patients. Many clinical studies, such as the NSABP B-32, have demonstrated that SLNB can safely replace axillary lymph node dissection (ALND) for patients with clinically node-negative breast cancer. However, it may not be applicable for male breast cancer (MBC) patients because they have notably different clinicopathological features from those occurring in females. There is a lack of evidence of SLNB application and safe exemption from ALND in MBC patients. This study aimed to eval

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Wong, Patrick Pak-Chun, Jianquan Cao, Zhewen Xiong, et al. "Abstract 6524: Single-cell landscape of cancer-associated fibroblasts in immunotherapy resistance of hepatocellular carcinoma." Cancer Research 84, no. 6_Supplement (2024): 6524. http://dx.doi.org/10.1158/1538-7445.am2024-6524.

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Abstract Introduction: The advent of immune checkpoint blockade (ICB) therapy has revolutionized the treatment approach for hepatocellular carcinoma (HCC). However, the response rate to ICB therapy remains low (below 20%). This limited response rate can be attributed to the considerable heterogeneity observed in HCC cells and the tumor microenvironment (TME). Recent research has highlighted the pivotal role of cancer-associated fibroblasts (CAFs) in orchestrating various components within the TME of HCC. Although the significance of lipid metabolism-associated CAFs in the efficacy of ICB thera

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Kan, Weiyue. "Yan wei xin sheng: Ming Qing shidai nüxing shengyin yu nanxing qigai zhi jiangou 言為心聲:明清時代女性聲音與男性氣概之建構 (A study of women’s voices in constructing masculinities in Ming-Qing China), written by Yu Hin Kelvin Ho (He Yuxuan) 何宇軒". NAN NÜ 24, № 1 (2022): 166–69. http://dx.doi.org/10.1163/15685268-02410041.

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Li, Xin, Feng Shen, Limin Zhang, et al. "Abstract 7279: Discovery of SHR1127, an orally bioavailable, highly potent and selective KRAS G12D inhibitor." Cancer Research 84, no. 6_Supplement (2024): 7279. http://dx.doi.org/10.1158/1538-7445.am2024-7279.

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Abstract Mutant KRAS is the most frequent oncogenic driver in nearly 23% of human cancers. As the most common KRAS alteration, KRAS G12D mutation occurs in approximately 35%, 13%, and 4% of pancreatic, colorectal, and non-small cell lung cancers, respectively. It was worth noting that the clinical PoC of KRAS G12D inhibitor has been preliminarily validated by intravenous administration of HRS-4642 weekly. However, there still represents an extraordinary unmet clinical need requiring an oral KRAS G12D inhibitor featuring higher potency and favorable pharmacokinetic profiles. We disclose herein

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Chen, Fei, Burcu F. Darst, Xin Sheng, et al. "Abstract 1182: Association of prostate cancer candidate genes with overall and aggressive prostate cancer in men of African ancestry." Cancer Research 83, no. 7_Supplement (2023): 1182. http://dx.doi.org/10.1158/1538-7445.am2023-1182.

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Abstract Background: There is a growing body of evidence supporting the contributions of germline rare variants to the susceptibility of prostate cancer (PCa), especially aggressive PCa. Our previous exome sequencing analysis highlighted 36 aggressive PCa candidate genes in populations of European ancestry. Here we investigated whether rare germline pathogenic, likely pathogenic, or deleterious (P/LD/D) variants in these genes were associated with overall and aggressive PCa risk in men of African ancestry. Methods: This exome sequencing analysis consists of 7,176 prostate cancer cases and 4,87

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Jiang, Yu, Amin Zhang, Minjuan Deng, et al. "Abstract 2232: BGB-R046, an IL-15 pro-drug demonstrates robust pharmacodynamic effects and immune activation within tumor microenvironment in a mouse syngeneic model." Cancer Research 85, no. 8_Supplement_1 (2025): 2232. https://doi.org/10.1158/1538-7445.am2025-2232.

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Abstract Background: Interleukin-15 (IL-15) is crucial for the proliferation and survival of NK and memory T cells, and has great potential in cancer immunotherapy. Rapid plasma clearance of conventional IL-15 and therefore insufficient tumor exposure and immune activation pose a significant limitation in its development as an immuno-oncology therapeutics. BGB-R046 is developed as an IL-15 pro-drug, which masks free drug release in circulation and is activated in tumors by utilizing tumor enriched proteases to release active IL-15Rα-sushi-IL-15, an IL-15 super-agonist(SITC#950). BGB-R046 induc

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Wang, Minghui, Yanhong Shang, Zhengang Yuan, et al. "Abstract 3650: AI-based MTB assistant in cancer personalized treatment: Analysis from a real-world, multi-center retrospective study." Cancer Research 85, no. 8_Supplement_1 (2025): 3650. https://doi.org/10.1158/1538-7445.am2025-3650.

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Abstract Background: Developing personalized treatment plans in cancer care is a complex and time-intensive process. The multidisciplinary Molecular Tumor Board (MTB) approach offers a promising solution for tailoring precision treatments but is often limited by the manual analysis of vast molecular data, which is laborious and error-prone. To address these challenges, we developed SmartMTB, an artificial intelligence (AI)-based assistant, designed to support clinicians in formulating cost-effective and efficient personalized treatment plans. Methods: SmartMTB leverages a medical-field-customi

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Wang, Anqi, Yili Xu, Xin Sheng, et al. "Abstract 3508: Association between clonal hematopoiesis and risk of prostate cancer in a large sample of African ancestry men." Cancer Research 83, no. 7_Supplement (2023): 3508. http://dx.doi.org/10.1158/1538-7445.am2023-3508.

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Abstract Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with inflammation, which is a risk factor for cancer, including prostate cancer. We previously reported weak evidence of an association between CHIP and prostate cancer risk in men of European ancestry. However, little is known for African ancestry populations. We investigated the association of age-related CHIP with overall and aggressive prostate cancer risk in a large whole-exome sequencing study of 12,049 African ancestry men, including 7,176 prostate cancer cases (of which 3,283 had aggressive disease and

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Li, Yu-Wei, Ding Ma, Xiang-Rong Wu, et al. "Abstract PS09-09: Multiomics profiling and molecular classification refine precision treatment strategies for HER2-positive breast cancer." Cancer Research 84, no. 9_Supplement (2024): PS09–09—PS09–09. http://dx.doi.org/10.1158/1538-7445.sabcs23-ps09-09.

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Abstract Background: Anti-HER2 targeted therapy has achieved a series of breakthroughs. However, the current treatment strategy regarding HER2-positive breast cancer remains indiscriminate and lacks specificity, which limits the further improvement of overall treatment response and may lead to overtreatment and extra cost for some patients. Our study aims to reveal the molecular heterogeneity of HER2-positive breast cancer to guide a more precise treatment. Patients and methods: We selected HER2-positive breast cancer patients treated at Fudan University Shanghai Cancer Center between 2013 and

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