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Relevant bibliographies by topics / XLR-11

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Journal articles

Academic literature on the topic 'XLR-11'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "XLR-11"

1

Wohlfarth, Ariane, Shaokun Pang, Mingshe Zhu, et al. "First Metabolic Profile of XLR-11, a Novel Synthetic Cannabinoid, Obtained by Using Human Hepatocytes and High-Resolution Mass Spectrometry." Clinical Chemistry 59, no. 11 (2013): 1638–48. http://dx.doi.org/10.1373/clinchem.2013.209965.

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BACKGROUND Since the mid-2000s synthetic cannabinoids have been abused as recreational drugs, prompting scheduling of these substances in many countries. To circumvent legislation, manufacturers constantly market new compounds; [1-(5-fluoropentyl)indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone (XLR-11), the fluorinated UR-144 analog, is one of the most recent and widely abused drugs, and its use is now linked with acute kidney injury. Our goal was to investigate XLR-11 metabolism for identification of major urinary targets in analytical methods and to clarify the origin of metabolites wh

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2

Alzu’bi, Ayman, Mazhar Salim Al Zoubi, Bahaa Al-Trad, et al. "Acute Hepatic Injury Associated with Acute Administration of Synthetic Cannabinoid XLR-11 in Mouse Animal Model." Toxics 10, no. 11 (2022): 668. http://dx.doi.org/10.3390/toxics10110668.

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The widespread recreational use of synthetic cannabinoids (SCs) has become a serious health issue. Reports of life-threatening intoxications related to SC consumption have markedly increased in recent years, including neurotoxicity, cardiotoxicity, nephrotoxicity, and hepatotoxicity. We investigated the impact of acute administration of the synthetic cannabinoid XLR-11 (3 mg/kg, i.p. for 5 consecutive days) on the liver in BALB/c mouse animal model. Using real-time quantitative RT-PCR, MDA assay, and TUNEL assay, we found consistent up-regulation of a variety of genes involved in oxidative str

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3

Shanks, Kevin G., David Winston, John Heidingsfelder, and George Behonick. "Case reports of synthetic cannabinoid XLR-11 associated fatalities." Forensic Science International 252 (July 2015): e6-e9. http://dx.doi.org/10.1016/j.forsciint.2015.04.021.

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4

Klein, M. G., and J. J. Moyseenko. "Control of Japanese Beetle Adults on Rose With Sevin, 1985." Insecticide and Acaricide Tests 11, no. 1 (1986): 430. http://dx.doi.org/10.1093/iat/11.1.430.

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Abstract The container grown roses were trimmed immediately prior to spraying to remove damaged foliage and provide similar sized plants. Flower blossoms were trimmed from the plants as they opened through the test period. Four 3-plant replicates were arranged in a randomized complete block in a mowed field in Wooster, OH. All treatments were sprayed 30 Jul. Sevin 80S was applied with a hand-pumped compressed air sprayer to the point of runoff. Sevin XLR Plus was applied with an ultra-low volume applicator at 1 part XLR in 11 parts water and 1 part XLR in 39 parts water. Treatments were evalua

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5

Banister, Samuel D., Jordyn Stuart, Richard C. Kevin, et al. "Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135." ACS Chem Neurosci 6, no. 8 (2015): 1445–58. https://doi.org/10.1021/acschemneuro.5b00107.

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Synthetic cannabinoid (SC) designer drugs featuring bioisosteric fluorine substitution are identified by forensic chemists and toxicologists with increasing frequency. Although terminal fluorination of <em>N</em>-pentyl indole SCs is sometimes known to improve cannabinoid type 1 (CB<sub>1</sub>) receptor binding affinity, little is known of the effects of fluorination on functional activity of SCs. This study explores the <em>in vitro</em> functional activities of SC designer drugs JWH-018, UR-144, PB-22, and APICA, and their respective terminally fluorinated analogues AM-2201, XLR-11, 5F-PB-2

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6

Lemos, Nikolas P. "Driving Under the Influence of Synthetic Cannabinoid Receptor Agonist XLR-11." Journal of Forensic Sciences 59, no. 6 (2014): 1679–83. http://dx.doi.org/10.1111/1556-4029.12550.

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7

Hataoka, Kyoko, Asuka Kaizaki-Mitsumoto, Mika Takebayashi-Ohsawa, Natsumi Hattori, Masahiko Funada, and Satoshi Numazawa. "Hyperreflexia induced by XLR-11 smoke is caused by the pyrolytic degradant." Forensic Toxicology 37, no. 2 (2019): 412–23. http://dx.doi.org/10.1007/s11419-019-00476-z.

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8

Lefever, Timothy W., Julie A. Marusich, Brian F. Thomas, et al. "Vaping Synthetic Cannabinoids: A Novel Preclinical Model of E-Cigarette Use in Mice." Substance Abuse: Research and Treatment 11 (January 1, 2017): 117822181770173. http://dx.doi.org/10.1177/1178221817701739.

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Smoking is the most common route of administration for cannabis; however, vaping cannabis extracts and synthetic cannabinoids (“fake marijuana”) in electronic cigarette devices has become increasingly popular. Yet, most animal models used to investigate biological mechanisms underlying cannabis use employ injection as the route of administration. This study evaluated a novel e-cigarette device that delivers aerosolized cannabinoids to mice. The effects of aerosolized and injected synthetic cannabinoids (CP 55,940, AB-CHMINACA, XLR-11, and JWH-018) in mice were compared in a battery of bioassay

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9

Nielsen, Line Marie, Niels Bjerre Holm, Lars Olsen, and Kristian Linnet. "Cytochrome P450-mediated metabolism of the synthetic cannabinoids UR-144 and XLR-11." Drug Testing and Analysis 8, no. 8 (2015): 792–800. http://dx.doi.org/10.1002/dta.1860.

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10

Louis, Asa, Brianna L. Peterson, and Fiona J. Couper. "XLR-11 and UR-144 in Washington State and State of Alaska Driving Cases." Journal of Analytical Toxicology 38, no. 8 (2014): 563–68. http://dx.doi.org/10.1093/jat/bku067.

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