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Journal articles on the topic 'Xylene-induced oedema'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Antwi-Adjei, Meshack, George Owusu, and Evans P. K. Ameade. "Aqueous extract of Lannea microcarpa attenuates dextran sulphate-induced paw oedema and xylene-induced ear oedema in rodents." International Journal of Basic & Clinical Pharmacology 6, no. 5 (2017): 1048. http://dx.doi.org/10.18203/2319-2003.ijbcp20171655.

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Background: Lannea microcarpa Engl. and K. Krause (Family Anacardiaceae), a tropical tree is used traditionally used in Africa for both medicinal and non-medicinal purposes. Folkoric uses of the plant include wound healing, conjunctivitis, stomatitis and gingivitis among others. Inflammatory reactions are involved in several diseases which this plant is traditionally used to manage. This study was therefore aimed at investigating the antiinflammatory effects of the aqueous extract of Lannea microcapa.Methods: Oedema was induced in the right hind paws of Sprague Dawley rats (200-250g, 12 weeks

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Umoh, Uwemedimo Francis, Ekikere Ezekiel Ubengama, Gina Ramos, and Victor Chubueze Onyido. "Quantitative Analysis, Anti-Inflammatory and Analgesic Effects of Ethanol Leaf Extract and Fractions of Microsorium scolopendria (Burm. f.) Copel. in Mice." Biology, Medicine, & Natural Product Chemistry 13, no. 2 (2024): 497–503. http://dx.doi.org/10.14421/biomedich.2024.132.497-503.

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Microsorium scolopendria, a fern was studied for phytochemicals, anti-inflammatory, and analgesic effects to add credence to its various folkloric applications. Phytochemicals were analyzed quantitatively, anti-inflammatory experiment was carried out with egg albumin- induced paw oedema and xylene-induced ear oedema models while analgesic effects were studied using formalin-induced paw licking, acetic acid-induced writhing and hot plate-induced pain models. The results revealed the presence of alkaloids, flavonoids, saponins, tannins, terpenoids, and phenols with alkaloids (14.6 %w/w) as the m

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3

Emmanuel, Uka, Godwin Ewere Efosa, and Sylvester Effiong Grace. "Anti-inflammatory potential of ethanol leaf extract of Sphenocentrum jollyanum in experimental mice." GSC Advanced Research and Reviews 7, no. 1 (2021): 146–56. https://doi.org/10.5281/zenodo.4766407.

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Anti-inflammatory potential of the ethanol leaf extract of <em>Sphenocentrum jollyanum</em> (ELESJ) was assessed in-vivo in mice by using carrageenan-induced paw oedema, egg albumin-induced paw oedema, and xylene-induced ear oedema model at doses of 474.34, 948.68, and 1423.03 mg/kgbw respectively. A total of seventy-five matured mice of both sexes weighing between 20 g and 24 g (divided into three groups of 25 mice each for the 3 different studies) were used for this study. Treatment was done intraperitoneally. Distilled water (10 mL/kgbw), acetylsalicylic acid (ASA) (100 mg/kgbw) o

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4

Emmanuel Uka, Efosa Godwin Ewere, and Grace Sylvester Effiong. "Anti-inflammatory potential of ethanol leaf extract of Sphenocentrum jollyanum in experimental mice." GSC Advanced Research and Reviews 7, no. 1 (2021): 146–56. http://dx.doi.org/10.30574/gscarr.2021.7.1.0086.

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Anti-inflammatory potential of the ethanol leaf extract of Sphenocentrum jollyanum (ELESJ) was assessed in-vivo in mice by using carrageenan-induced paw oedema, egg albumin-induced paw oedema, and xylene-induced ear oedema model at doses of 474.34, 948.68, and 1423.03 mg/kgbw respectively. A total of seventy-five matured mice of both sexes weighing between 20 g and 24 g (divided into three groups of 25 mice each for the 3 different studies) were used for this study. Treatment was done intraperitoneally. Distilled water (10 mL/kgbw), acetylsalicylic acid (ASA) (100 mg/kgbw) or dexamethasone (4

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Igbe, Ighodaro, Osaze Edosuyi, Agbonlahor Okhuarobo, Adarki Pongri, Nkechi Maduako, and Isaac Ehimen. "Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents." Herba Polonica 65, no. 3 (2019): 22–31. http://dx.doi.org/10.2478/hepo-2019-0015.

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Summary Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber moth Cussonia barteri is a small tree that grows in the sub-Saharan part of Africa. Various parts of the plant are used for the treatment of a variety of ailments in ethno-medicine. Objective: To evaluate the anti-inflammatory and analgesic effect of the methanol leaf extract of Cussonia barteri. Material and methods: The leaves were air-dried, powdered and repeatedly extracted with methanol using a Soxhlet apparatus. The resulting methanol extract (100, 200 and 400 mg/kg) was evaluated fo

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G. C., Subarna Akuodor, Ohadoma S. C., Ofor C. C., et al. "Anti-nociceptive, anti-inflammatory and antipyretic activities of the ethanol root bark extract of Salacia lehmbachii in rats and mice." International Journal of Basic & Clinical Pharmacology 10, no. 6 (2021): 614. http://dx.doi.org/10.18203/2319-2003.ijbcp20212066.

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Background: The decoction of the roots of Salacia lehmbachi is used in traditional medicine for the treatment different diseases such as malaria pains diabetes and microbial infections.Methods: Phytochemical screening and oral acute toxicity tests were carried out on the ethanol root extract of the plant. Anti-nocicetive activity using acetic acid induced writhing and tail immersion method in mice, anti-inflammatory activity using carrageenan induced paw oedema in rats and xylene induced ear oedema test in mice and antipyretic activity using Brewer’s yeast and D-amphetamine induced pyrexia in

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Okwesileze, C. N., G. A. Essiet, I. C. Okwesileze, and F. V. Udoh. "Effects of Dacryodes edulis Leaf Extract on Pain and Inflammation." Journal of Basic and Social Pharmacy Research 2, no. 1 (2021): 1–7. http://dx.doi.org/10.52968/27458154.

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Background: Dacryodes edulis leaf extract is used in traditional settings in management of many disease conditions including pain and inflammation. However, these empirical claims have not been evaluated scientifically. Objective: The objective of this study was to determine the effect of ethanol leaf extract of Dacryodes edulis on pain and inflammation using rodents. Materials and Methods: Writhing test using acetic acid for induction of pain and tail-immersion in temperature controlled water were used to study the effect on pain sensation while xylene-induced ear oedema and carrageenan-induc

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Ettebong, E. O., and P. A. Nwafor. "Anti-inflammatory and analgesic potentials of Eleucine indica." Journal of Phytopharmacology 3, no. 2 (2014): 130–38. http://dx.doi.org/10.31254/phyto.2014.3209.

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The plant Eleucine indica has a long ethnobotanical history because of its use in the treatment painful and inflammatory conditions. This study was aimed at investigating the antiinflammatory and analgesic activities of ethanolic extract of the whole plant in mice. The antiinflammatory activity was studied using carrageenin, egg albumin and xylene as phlogistic agents. The analgesic investigation was carried out against acetic acid-induced writhing, formalin-induced pain and hot-plate test. The extract (200 – 600 mg/kg) showed significant (p< 0.05 - 0.001) dose-dependent reductions in the m

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Uvo, Oghale Ovuakporie, MacDonald Idu, Philip Obarisiagbon, and Callistus Abode. "Analgesic, pro and anti-inflammatory activities of Desplatsia dewevrei; Cytokine gene expression using Wistar rats and mice." Journal of Phytopharmacology 7, no. 2 (2018): 185–90. http://dx.doi.org/10.31254/phyto.2018.7214.

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Objective: Painkilling potential of Desplatsia dewevrei methanol leaf extract was examined using the acetic acid-induced writhing and hot-plate tests. Materials & Methods: Acute anti-inflammatory effect was studied using xylene-induced ear edema and carrageenan induced paw edema models. Gene expression using RT-PCR method was used to query TNF-α, resistin and adiponectin in Wistar rats after a 3-day administration of Desplatsia dewevrei. Results: Desplatsia dewevrei extract significantly (p<0.05) decreased the number of writhes in mice at 30 mg/kg when compared to the control and Aspiri

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10

John, Enema, Onojah, Umoh, Uwemedimo Francis, Umoh, Uwemedimo Francis, Ekarika, C. Johnson, Khalid, Doudin, and Johnny, I. Imoh. "Isolation and Characterisation of Docosanoic Acid, Quercetin and Vitexin from Dennettia tripetala Bak. f. Root and Stem Bark and their In-vivo Anti-inflammatory and Analgesic Activities." Journal of Advances in Medicine and Medical Research 37, no. 3 (2025): 209–28. https://doi.org/10.9734/jammr/2025/v37i35758.

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Dennettia tripetala Baker f. (Annonaceae) is widely used in African traditional medicine for managing diabetes, inflammation, pain, and other ailments due to its diverse phytochemical composition. This study aimed to isolate and characterize bioactive compounds from the root and stem bark of D. tripetala and evaluate their anti-inflammatory and analgesic properties through in vivo models. The plant materials were extracted using 70% aqueous methanol, and the extracts were partitioned into n-hexane, dichloromethane, ethyl acetate, and n-butanol fractions. Compounds were isolated through open-co

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Mbaoji, Florence Nwakaego, Akachukwu Marytheresa Onwuka, Sunday Onu, Ikechukwu Emmanuel Peter, Justus Amuche Nweze, and Lilian Eleje Okonta. "Evaluation of Methanol-Dichloromethane Extract of Stemonocoleus micranthus Harms (Fabaceae) Stem Bark for Anti-Inflammatory and Immunomodulatory Activities." Evidence-Based Complementary and Alternative Medicine 2020 (May 7, 2020): 1–10. http://dx.doi.org/10.1155/2020/1738163.

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Background. The stem bark decoction of Stemonocoleus micranthus Harms (Fabaceae) is most widely used traditionally as a remedy for various diseases such as malaria and boil. In this study, the anti-inflammatory and immunomodulatory activities of the methanol-dichloromethane extract (MDE) from the stem bark of the plant in rodents were evaluated. Methods. The carrageenan-induced rat paw oedema, cotton pellet-induced granuloma in rat, and xylene-induced ear oedema in mice were used to study the anti-inflammatory activity of methanol-dichloromethane extract of Stemonocoleus micranthus (MDESm) (10

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12

Zhao, Jun, Aosimanjiang Maitituersun, Chenyang Li, Qian Li, Fang Xu, and Tao Liu. "Evaluation on Analgesic and Anti-Inflammatory Activities of Total Flavonoids from Juniperus sabina." Evidence-Based Complementary and Alternative Medicine 2018 (July 5, 2018): 1–9. http://dx.doi.org/10.1155/2018/7965306.

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The leaves of Juniperus sabina (Cupressaceae) are used in traditional Uygur medicine for the treatment of rheumatism and arthritic pain. This study aimed to investigate the analgesic and anti-inflammatory effects of total flavonoids from leaves of Juniperus sabina (JSTF) on rodents. The anti-inflammatory activity was investigated using the carrageenan, egg albumin, or histamine-induced rat paw edema as well as xylene-induced ear edema, capillary permeability, and cotton pellet granuloma while the antinociceptive activity was evaluated using the mouse writhing, formalin, and hot-plate tests. JS

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13

Chukwubuikem C. Okolo, Nancy A. Mbachu, Ogechi O. Anyanwu, Kenneth G. Ngwoke, and Festus B.C. Okoye. "Screening for anti-inflammatory activity of extract and fractions of Morinda lucida stem bark and detection of bioactive secondary metabolite." GSC Biological and Pharmaceutical Sciences 16, no. 1 (2021): 031–39. http://dx.doi.org/10.30574/gscbps.2021.16.1.0077.

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Morinda lucida Benth (Rubiaceae) is a versatile plant used in traditional medicine for the treatment of a variety of ailments and the claims of its efficacy are particularly remarkable in the treatment of infections and immuno-inflammatory disorders. This study evaluates the anti-inflammatory properties of methanolic stem bark extract and fractions of M. lucida and also identifies the phytochemicals responsible for its anti-inflammatory activity. The crude extract was subjected to liquid- liquid partitioning successively with n- hexane, ethylacetate, butanol and water. High performance liquid

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14

Chukwubuikem, C. Okolo, A. Mbachu Nancy, O. Anyanwu Ogechi, G. Ngwoke Kenneth, and B.C. Okoye Festus. "Screening for anti-inflammatory activity of extract and fractions of Morinda lucida stem bark and detection of bioactive secondary metabolite." GSC Biological and Pharmaceutical Sciences 16, no. 1 (2021): 031–39. https://doi.org/10.5281/zenodo.5128611.

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<em>Morinda lucida</em> Benth (Rubiaceae) is a versatile plant used in traditional medicine for the treatment of a variety of ailments and the claims of its efficacy are particularly remarkable in the treatment of infections and immuno-inflammatory disorders. This study evaluates the anti-inflammatory properties of methanolic stem bark extract and fractions of <em>M. lucida</em> and also identifies the phytochemicals responsible for its anti-inflammatory activity. The crude extract was subjected to liquid- liquid partitioning successively with n- hexane, ethylacetate, butanol an

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15

FRANCIS UMOH, UWEMEDIMO. "PROTEA MADIENSIS OLIVER (PROTEACEAE) ROOT EXTRACT AND FRACTIONS IN INFLAMMATION AND PAIN MANAGEMENT IN MICE." AFRICAN JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT 17, no. 1 (2025): 38–43. https://doi.org/10.59493/ajopred/2025.1.5.

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Protea madiensis root, was studied for anti-inflammatory and analgesic properties to verify its local applications. After the collection of whole plants, roots were separated, washed and shade dried. The pulverized root was cold macerated with ethanol (70%) for 72 h, filtered and concentrated in vacuo at 40ºC. A portion of the extract was introduced into a separating funnel and successively partitioned with dichloromethane, ethyl acetate and butanol to obtain partitioned fractions (dichloromethane, ethyl acetate and butanol fractions). The remaining ethanol extract was screened for secondary m

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16

O, Okorie, Akuodor GC, Ifediba CE, Ofor CC, and Afonne OJ. "In Rodents, Methanol Extract from Ritchiea capparoides leaf has Analgesic, Anti-Inflammatory, and Antipyretic Properties." Asian Journal of Research in Medical and Pharmaceutical Sciences 13, no. 2 (2024): 21–31. http://dx.doi.org/10.9734/ajrimps/2024/v13i2252.

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Background: Ritchiea capparoides leaves are traditionally used in Southern Nigeria to cure fever, snake bites, aches, and malaria. Consequently, the analgesic, anti-inflammatory, and antipyretic properties of Ritchiea capparoides leaf ethanol extract were assessed in rodents in this work. Methods: Using acetic acid and tail immersion models in mice, the analgesic effect was investigated, and xylene, egg-albumen, brewer's yeast, and dinitrophenol models were used to investigate the anti-inflammatory and antipyretic properties in mice and rats at doses of 125 mg/kg, 250 mg/kg, and 500 mg/kg of t

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17

Wang, Guangxi, Zhiqiang Hu, Xu Song, et al. "Analgesic and Anti-Inflammatory Activities of Resveratrol through Classic Models in Mice and Rats." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/5197567.

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Background. Inflammation and pain are closely related to humans’ and animals’ health.Resveratrol(RSV) is a natural compound with various biological activities. The current study is aimed to evaluate the analgesic and anti-inflammatory activities of RSV in vivo. Materials and Methods. The analgesic effects were assessed by the acetic acid-induced writhing and hot plate tests. The anti-inflammatory effects were determined using the xylene-induced mouse ear oedema, the acetic acid-induced rat pleurisy, and carrageenan-induced rat synovitis tests, respectively.Results. The analgesic results showed

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Ibekwe, N. N., N. N. Ibekwe, and L. B. John-Africa. "Anti-inflammatory Effect of the Alkaloid-rich Fraction of Landolphia owarensis." Nigerian Journal of Pharmaceutical Research 17, no. 1 (2021): 39–44. http://dx.doi.org/10.4314/njpr.v17i1.4.

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Background: Plants have several chemical compounds acclaimed to be responsible for the pharmacological actions produced when herbal products are administered to biological systems.Objectives: This study was designed to investigate the anti-inflammatory effect of the alkaloid-rich fraction of the ethanol leaf extract of Landolphia owariensis.Methods: Qualitative phytochemical analyses were carried on the crude extract using standard methods. The alkaloid-rich fraction was obtained from the crude ethanol extract, using the classical acid/base shake-up method and the obtained fraction tested posi

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Olela, Ben, James Mbaria, Timothy Wachira, and Gervason Moriasi. "Acute Oral Toxicity and Anti-inflammatory and Analgesic Effects of Aqueous and Methanolic Stem Bark Extracts of Piliostigma thonningii (Schumach.)." Evidence-Based Complementary and Alternative Medicine 2020 (August 7, 2020): 1–10. http://dx.doi.org/10.1155/2020/5651390.

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Inflammation and pain are devastating conditions characterizing many diseases. Their manifestation ranges from mild body discomfort, to a debilitating experience, which may culminate in organ failure or death. In conventional medicine, corticosteroids, nonsteroidal anti-inflammatory drugs, opioids, and adjuvants are utilized to manage symptoms related to pain and inflammation. Despite their reported successes, these agents are only palliative, debatably inaccessible, unaffordable, and cause many undesirable side effects. As a result, the search for alternative and complementary therapies is wa

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20

Essien, Augustine D., Grace A. Essiet, Godwin C. Akuodor, Edidara E. Thomas, and Francis V. Udoh. "Anti-inflammatory and anti-nociceptive potentials of Salacia lehmbachii leaves." Journal of Drugs and Pharmaceutical Science 1, no. 1 (2017): 1–8. http://dx.doi.org/10.31248/jdps2017.009.

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For decades, the leaves of Salacia lehmbachii Loes (SL), which belong to the family of Celastraceae are acceptably used in south-eastern parts of Nigeria in traditional medicine for the treatment of fever and painful conditions. This study assessed the anti-inflammatory and anti-nociceptive effects of its water extracts on inflammation and nociception in rats. Doses of 100, 200 and 400 mg/kg of water extract of SL were used in elucidating anti-inflammatory activities in Wistar rats and mice by using carrageenan, egg albumin-induced paw and xylene-induced ear oedema; while acetic acid-induced w

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Jiang, Siyi, Qiong Wei, Xiaochuan Ye та ін. "The Anti-Inflammatory Effect of Smilax china L. Extract on LPS-Stimulated THP-1 via Downregulation of MAPK and NF-κB Signaling Pathway". Evidence-Based Complementary and Alternative Medicine 2021 (16 листопада 2021): 1–12. http://dx.doi.org/10.1155/2021/9958808.

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Background. Traditional Chinese medicine Smilax is the rhizome of liliaceous plant Smilax china L., which is used to treat pelvic inflammatory disease and anxieties. Purpose. To investigate the mechanism of anti-inflammatory activity of the extract from Smilax china L. (ES). Methods. The components of ES were identified by UPLC-QTOF-MS/MS. The anti-inflammatory activities were evaluated in xylene-induced ear oedema and egg white-induced plantar swelling test. Cell viability was examined by CCK-8 assay. The inflammatory mediators, proinflammatory cytokines, and MAPK and NF-κB signals in LPS-sti

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Shubhra Rai, Gopal Rai, and Ashish Budhrani. "Development, Optimisation and Evaluation of Ketoprofen Lipospheres." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1853–63. http://dx.doi.org/10.26452/ijrps.v11ispl4.4389.

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Lipospheres represent a novel type of fat-based encapsulation system produced for the topical drug delivery of bioactive compounds. The goal of this research work was to develop lipospheres, including ketoprofen applied for topical skin drug delivery. Ketoprofen lipospheres were formulated by melt emulsification method using stearic acid and Phospholipon® 90G. The lipospheres were analysed in terms of particle size and morphology, entrapment efficiency, Differential scanning calorimetry, In-vitro drug release, In-vivo (Anti-inflammatory activity). Outcomes of research revealed that particle si

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Umoh, U. F., I. I. Johnny, M. N. Igwe, O. A. Ojo, E. U. Udofia, and E. James. "Phytochemical analysis, anti-inflammatory and analgesic efficacy of the ethanol leaf extract and fractions of <i>Spondia dulcis</i> in mice." World Journal of Applied Science & Technology 16, no. 2 (2025): 295–99. https://doi.org/10.4314/wojast.v16i2.295.

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The design of this work was to screen the ethanol leaf extract of Spondias dulcis for its phytochemicals and study the antiinflammatory and analgesic efficacy in mice to support its local use in pain and inflammatory diseases management. The leaves of S. dulcis were collected, shade dried, pulverised and extracted with ethanol (60%) for 72 hours. Filtration was achieved by the use of Whatman filter paper and the filtrate was concentrated in vacuo. Part of the ethanol extract (100 g) was partitioned successively with n-hexane, dichloromethane, ethyl acetate and butanol and the various fractions

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Cardoso-Daodu, WIbilola M., Chidinma S. Mmaduabuchukwu, Margaret O. Ilomuanya, and Chukwuemeka P. Azubuike. "Evaluation of Anti-nociceptive and Anti-Inflammatory Effects of Markhamia tomentosa Cream Co-Formulated with Eucalyptus Oil." Pan African Journal of Life Sciences 7, no. 3 (2023): 723–33. http://dx.doi.org/10.36108/pajols/3202/70.0350.

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Background: Pain is a noxious, sensory, and emotional experience due to intense stimuli. Pain is intimately linked with nociception. The clinical therapies available at the moment for pain are tricyclic antidepressants, non -steroidal anti-inflammatory drugs, and opioids. There is a need to develop and investigate safer alternatives that minimise the chances of psychological or physical drug dependence and drug dose tolerance. The purpose of this research is to develop an anti-inflammatory and anti-nociceptive formulation (Markhamia tomentosa cream co-formulated with Eucalyptus oil as a permea

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Fristiohady, Adryan, Taifo Mahmud, Nuralifah Nuralifah, et al. "Anti-Inflammatory Activities of Lycopene on Xylene-Induced Ear Oedema in Mice and its In-Vitro Evaluation towards Protein Denaturation." Research Journal of Pharmacy and Technology, March 27, 2025, 1052–57. https://doi.org/10.52711/0974-360x.2025.00151.

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This study aims to evaluate the anti-inflammatory activity of Lycopene in mice with ear oedema and in vitro activity. In this study, mice were used and performed in vitro anti-inflammatory tests of Lycopene with the HRBC method and protein denaturation. Moreover, the anti-inflammatory assay of Lycopene was also evaluated in xylene-induced right-ear mice. Diclofenac sodium solution was used as a positive control. The results showed that Lycopene provides anti-inflammatory activity in vitro by stabilizing the human red blood cell (HRBC), preventing lysis, and inhibiting protein denaturation with

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Dey Ray, Sarbani, Sulagna Dutta, Pallav Sengupta, et al. "ELUCIDATION OF ANTI-INFLAMMATORY ACTIVITY OF A NEW CYCLIC ALKALOID COMPOUND FROM ROOT BARK OF ZIZIPHUS NUMMULARIA (AUBREV.): IN VITRO, IN SILICO AND IN VIVO STUDIES." Journal of microbiology, biotechnology and food sciences 13, no. 5 (2024). http://dx.doi.org/10.55251/jmbfs.10564.

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Inflammatory diseases present a significant burden to global health, often requiring targeted and specific therapeutic agents for effective management. Ziziphus nummularia (Aubrev.), a traditional medicinal plant, offers a potential source for these agents. This article aims to explore the anti-inflammatory potential of a novel cyclic alkaloid compound isolated from the root bark of Ziziphus nummularia. The cyclic alkaloid compound, [(16-methoxy-10-(3-methyl-butyl)-2-oxa-6, 9, 12-triaza-tricyclo [13.3.1.03, 7] nonadeca-1(18), 13, 15(19), 16-tetraene-8, 11-Dione], exhibited promising anti-infla

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Said, Khalil, Muhammad Hamayun, Mamoona Rauf, et al. "Simultaneous Study of Analysis of Anti-inflammatory Potential of Dryopteris ramosa (C. Hope) C. Chr. using GC- Mass and Computational Modeling on the Xylene- Induced Ear Oedema in Mouse Model." Current Pharmaceutical Design 30 (December 18, 2023). http://dx.doi.org/10.2174/0113816128290636231129074039.

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Introduction:: In the present study, we aimed to investigate the extraction and identification of the potential phytochemicals from the Methanolic Extract of Dryopteris ramosa (MEDR) using GC-MS profiling for validating the traditional uses of MEDR its efficacy in inflammations by using in-vitro, in-vivo and in silico approaches in anti-inflammatory models. background: The search for a safe alternative therapy utilizing herbal resources has received emphasis in recent decades since herbs play a vital role in the contemporary medical system and operate as a massive worldwide reservoir for possi

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"In vitro and animal model estimation of the anti Open Access inflammatory and antinociceptive activities of Abrus precatorius (fabaceae) plant-mediated nanoparticles." Health Sciences Investigations Journal, Volume 6 Issue 2 (December 30, 2024): 932–42. https://doi.org/10.46829/hsijournal.2024.12.6.2.932-942.

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Background: Recent research indicates that biosynthesized metal nanoparticles from natural products such as plants often exhibit higher therapeutic efficacy and reduced toxicity compared to natural products at macro-scale or chemically-synthesized nanoparticles. The potential therapeutic compounds in natural products usually act as capping agents on synthesized nanoparticles, facilitating targeted delivery of those compounds at lower, more effective doses. Given the roles of inflammation, oxidative stress, and nociception in diseases, developing novel drugs with enhanced efficacy and reduced t

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Ma, Quhuan, Yanmei Lu, Yi Deng, et al. "Optimization for ultrasonic-microwave synergetic extraction of total iridoid glycosides and screening of analgesic and anti-inflammatory active fractions from patrinia scabra Bunge (Valerianaceae)." BMC Complementary Medicine and Therapies 22, no. 1 (2022). http://dx.doi.org/10.1186/s12906-021-03489-7.

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Abstract Background Patrinia scabra Bunge is a well-known herbal medicine for its favorable treatment on inflammatory diseases owing to its effective ingredients, in which iridoid glycoside plays an extremely significant role. This article aimed to improve the content of total iridoid glycosides in crude extract through a series optimization of extraction procedure. Moreover, considering that both pain and inflammation are two correlated responses triggered in response to injury, irritants or pathogen, the article investigated the anti-inflammatory and analgesic activities of P. scabra to scre

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