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1

Solominchuk, Tetiana, Vitalii Rudiuk, Nataliia Smielova, Alina Deyneka, Tetiana Nesteruk, and Victoriya Georgiyants. "Xylometazoline base suitable for use in lipophilic drug products: development of production technology and analytical methods for quality control." ScienceRise: Pharmaceutical Science, no. 4 (50) (August 30, 2024): 14–22. http://dx.doi.org/10.15587/2519-4852.2024.310656.

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The aim: development of the technology for obtaining the base of xylometazoline, suitable for the development of formulations in combination with essential oils. Development and validation of methods of control of related substances and assay of the obtained base of xylometazoline. Study of the stability of the obtained xylometazoline base under long-term and accelerated conditions. Materials and methods: experimental samples of xylometazoline base were obtained from commercially available xylometazoline hydrochloride and aqueous sodium hydroxide solution. The quality control of the obtained s
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2

Humphreys, M. R., D. Grant, S. A. McKean, C. Y. Eng, J. Townend, and A. S. Evans. "Xylometazoline hydrochloride 0.1 per cent versus physiological saline in nasal surgical aftercare: a randomised, single-blinded, comparative clinical trial." Journal of Laryngology & Otology 123, no. 1 (2008): 85–90. http://dx.doi.org/10.1017/s002221510800217x.

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AbstractObjectives:A variety of topical preparations are used for symptomatic relief following nasal surgery. The aim of this study was to compare the effect of two commonly used products on patient symptom scores following nasal surgery.Design:Randomised, single-blinded, comparative clinical trial.Setting:A single, secondary otorhinolaryngology centre.Participants:One hundred and twenty patients undergoing septoplasty or functional endoscopic sinus surgery as an isolated procedure between November 2003 and January 2006. Patients undergoing additional nasal procedures were excluded, as were th
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3

Bezshapochny, Sergey B., and Iryna S. Hychak. "Treatment of adenoid inflammation in children." OTORHINOLARYNGOLOGY, No2(4) 2021 (March 24, 2021): 60–65. http://dx.doi.org/10.37219/2528-8253-2021-2-60.

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Topicality: Inflammation of the adenoid tonsil is one of the common causes of ENT diseases in children. Among the causes of adenoiditis (nasopharyngitis) are infectious - viral and bacterial, allergic and gastric acid irritation in laryngopharyngeal reflux. The aim of our research was to study the effectiveness of topical application of a combination of xylometazoline hydrochloride 0.05% and miramistin 0.01% in the treatment of pediatric patients with pharyngeal tonsillitis. Materials and methods: We selected 60 patients aged 5 to 14 years with endoscopically confirmed adenoid vegetations of I
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4

Ghose, S., та J. K. Dattagupta. "Structure of xylometazoline (otrivin) hydrochloride, an α-adrenergic agonist". Acta Crystallographica Section C Crystal Structure Communications 42, № 11 (1986): 1524–26. http://dx.doi.org/10.1107/s0108270186091618.

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5

Divya, Jadhav, Shaikh Misbah, Jain Hitesh, Sahu Asit, and B. Meshram D. "Formulation and Evaluation Xylometazoline Hydrochloride Mucoadhesive Nasal in Situ Gel." International Journal of Pharmaceutical and Bio-Medical Science 02, no. 02 (2022): 18–22. https://doi.org/10.5281/zenodo.6090206.

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The objective of research is to develop a mucoadhesive in-situ nasal gel formulation of xylometazoline hydrochloride for the treatment of allergic rhinitis to avoid possible side effects. Mucoadhesive in-situ nasal gel of xylometazoline hydrochloride was formulated by ionic gelation method using xanthan gum as ionsensitive agent and different grades of HPMC as a viscosifying agent. The prepared batches were evaluated for drug content, pH, gelling time, spreadability, gelling strength, mucoadhesive strength and in-vitro drug release. In vitro drug release study was carried by using diffusion ce
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6

Joshi, K. S., V. W. Q. Ho, M. E. Smith, and J. R. Tysome. "The effect of topical xylometazoline on Eustachian tube function." Journal of Laryngology & Otology 134, no. 1 (2020): 29–33. http://dx.doi.org/10.1017/s0022215120000158.

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AbstractBackgroundTopical nasal decongestants are frequently used as part of the medical management of symptoms related to Eustachian tube dysfunction.ObjectiveThis study aimed to assess the effect of topical xylometazoline hydrochloride sprayed in the anterior part of the nose on Eustachian tube active and passive opening in healthy ears.MethodsActive and passive Eustachian tube function was assessed in healthy subjects before and after intranasal administration of xylometazoline spray, using tympanometry, video otoscopy, sonotubometry, tubo-tympano-aerodynamic-graphy and tubomanometry.Result
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Larisa, Alagić-Džambić, Dacić Minela, Frljak Amila, Osmanović Omerdić Ehlimana, and Džambić Mirsad. "RP-HPLC Method of the Estimation of Xylometazoline hydrochloride in Nasal Spray Solution." Chemistry Research Journal 5, no. 5 (2020): 31–34. https://doi.org/10.5281/zenodo.13144163.

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<strong>Abstract </strong>A simple, specific, precise and accurate reverse phase HPLC method has been developed for the determination of nasal decongestive, Xylometazoline hydrochloride in nasal spray solution. The chromatographic separation was achieved on column C18, 150 mmx4.6 mm, 3.5 &micro;m, using PDA detector. The mobile phase was acetonitrile and phosphate buffer pH 3.0 (60:40 v:v), at flow rate 1.0 mL/min, detected at 220 nm, at 35&ordm;C temperature for column. The retention times was at about 1.5minutes.The method was validated according to the ICH guidelines with respect to specifi
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8

Racheva, P. V., D. G. Hristov, and K. B. Gavazov. "Extraction-Chromogenic Systems for Gallium(III) Based on Azo Dyes and Xylometazoline Hydrochloride." Russian Journal of General Chemistry 90, no. 7 (2020): 1351–56. http://dx.doi.org/10.1134/s1070363220070245.

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9

Prajapati, Nilesh, Mayank Dalal, and Hasumati A. Raj. "Stability Indicating Liquid Chromatographic Method for Estimation of Xylometazoline Hydrochloride in Pharmaceutical Dosage Form." International Journal of Pharmaceutical Chemistry and Analysis 3, no. 3 (2016): 124. http://dx.doi.org/10.5958/2394-2797.2016.00019.8.

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10

Racheva, Petya V., Antoaneta D. Saravanska, Galya K. Toncheva, et al. "A Semi-Micro Extraction Spectrophotometric Determination of Iron Using 4-Nitrocatechol and Xylometazoline Hydrochloride." Molecules 30, no. 4 (2025): 899. https://doi.org/10.3390/molecules30040899.

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A chromogenic solvent extraction system for Fe(III) based on 4-nitrocatechol (4NC) and xylometazoline hydrochloride (XMH) was investigated. The optimum conditions for extraction spectrophotometric determination of iron were found. Under these conditions, the formula of the extracted complex was (XMH+)3[Fe(4NC)3] and the apparent molar absorption coefficient at λmax = 464 nm was 1.9 × 105 dm3 mol−1 cm−1 (4-fold enrichment). To validate the aforementioned formula and gather information about the spin state of the central Fe(III) ion, a combined experimental-theoretical approach was employed. Thi
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11

Anjaneyulu, Y., M. R. P. Reddy, and C. S. Kavipurapu. "Extractive spectrophotometric determination of chromium(III) in steels using 4-(2-pyridylazo)resorcinol and xylometazoline hydrochloride." Analyst 111, no. 10 (1986): 1167. http://dx.doi.org/10.1039/an9861101167.

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12

S., N. BHADANI, TEWARI MADHU, AGRAWAL ARCHANA, and SEKHAR. K. CHANDRA. "Extractive-photometric Determination of Cobalt(II) in Steels using 4-(2-Pyridylazo)resorcinol and Xylometazoline Hydrochloride." Journal of Indian Chemical Society Vol. 75, Mar 1998 (1998): 176–77. https://doi.org/10.5281/zenodo.5916333.

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Department of Chemistry, Ranchi University, Ranchi-834 008 Analytical Chemistry Division, National Metallurgical Laboratory, Jamshedpur-831 007 <em>Manuscript received 8 November 1995, revised 31 December 1996, accepted 12 June 1997</em> Cobalt(II) forms anionic chelates with 4-(2-pyridylazo)resorcinol (<strong>PAR</strong>) at pH 7.0-8.0, which can be quantitatively extracted into chloroform as an ion-pair with xylometazolonium cation (<strong>XMH</strong>). The ion-association system has an absorption maximum at 535 nm and obeys Beers law in the range 0-1.6 &micro;g of Co/ml with a molar abs
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13

Shamil, E., M. J. Rouhani, A. C. Panayi, J. Lynch, J. Tysome, and N. Jonas. "Investigating the effect of a nasal decongestant on post-adenotonsillectomy respiratory complications in 25 paediatric patients with obstructive sleep apnoea: a pilot study." Journal of Laryngology & Otology 133, no. 2 (2019): 110–14. http://dx.doi.org/10.1017/s0022215119000033.

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AbstractObjectiveAdenotonsillectomy is frequently performed for obstructive sleep apnoea, but is associated with post-operative respiratory morbidity. This study assessed the effect of paediatric Otrivine (0.05 per cent xylometazoline hydrochloride) on post-operative respiratory compromise.MethodsPaediatric patients undergoing adenotonsillectomy for obstructive sleep apnoea were included. The control group (n = 24) received no intervention and the intervention group (n = 25) received intra-operative paediatric Otrivine during induction using a nasal patty. Post-operative outcomes included pain
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14

Thulesius, Helle L., Anders Cervin, and Max Jessen. "Can we always trust rhinomanometry?" Rhinology journal 49, no. 1 (2011): 46–52. http://dx.doi.org/10.4193/rhino10.027.

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Objectives: Rhinomanometry before and after decongestion distinguishes a nasal airway organic stenosis from congestion of nasal mucosa in patients with nasal stuffiness. Together with rhinoscopy and patient history, it is used to decide if nasal surgery would benefit the patient. Rhinomanometry measurements should thus be reliable and reproducible. Materials and methods: We performed repetitive active anterior rhinomanometry in 9 persons during 5 months to test reproducibility of nasal airway resistance (NAR) over time. We also did test-retest measurements in several participants. Xylometazoli
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15

Samir, GhadaM, Niven Gerges-Fahmy, and HebaA Labib. "The effects of adding lidocaine hydrochloride nasal spray (10%) to xylometazoline nasal drops (0.1%) in functional endoscopic sinus surgery: a comparative study." Ain-Shams Journal of Anaesthesiology 9, no. 4 (2016): 598. http://dx.doi.org/10.4103/1687-7934.198262.

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16

Зарічна, Т. П., Н. О. Брагар, А. С. Гоцуля, and Т. С. Британова. "Research of the domestic market of medicinal products used for diseases of the nasal cavity." Farmatsevtychnyi zhurnal, no. 6 (December 27, 2024): 25–35. https://doi.org/10.32352/0367-3057.6.24.02.

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Diseases of the nasal cavity have a significant impact on overall health, as the nasal cavity is an important part of the respiratory system and performs significant functions in protecting the body. Well-known pathologies such as rhinitis, sinusitis, nasopharyngitis, and allergic rhinitis are common diseases that most people face throughout their lives. The study of the domestic market of medicinal products used in the treatment of nasal cavity diseases is extremely relevant today. In the context of the global pandemic, various viral or bacterial diseases with a decrease in immunity against t
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17

Graf, Christine, Andreas Bernkop-Schnürch, Alena Egyed, Christiane Koller, Eva Prieschl-Grassauer, and Martina Morokutti-Kurz. "Development of a nasal spray containing xylometazoline hydrochloride and iota-carrageenan for the symptomatic relief of nasal congestion caused by rhinitis and sinusitis." International Journal of General Medicine Volume 11 (July 2018): 275–83. http://dx.doi.org/10.2147/ijgm.s167123.

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18

Thulesius, H. L., A. Cervin, and M. Jessen. "Treatment with a topical glucocorticoid, budesonide, reduced the variability of rhinomanometric nasal airway resistance." Rhinology journal 52, no. 1 (2014): 19–24. http://dx.doi.org/10.4193/rhino12.180.

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Background: Previous rhinomanometry studies have shown significant long-term variability of the nasal airway resistance and questioned the clinical validity of rhinomanometry. Research question: Could treatment with a topical glucocorticoid, budesonide, influence the long-term variability of active anterior rhinomanometry? Methods: Eight healthy volunteers participated in an unblinded controlled trial without, and later with, nasal budesonide once a day for 5 months. Their nasal airway resistance was measured every two weeks with active anterior rhinomanometry before and after decongestion wit
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19

Vlaykov, Atanas, and Katarzyna Miśkiewicz-Orczyk. "Effect of IL-4, IL-5, IL-13, and IgE on Nasal Congestion in Patients with Allergic Rhinitis." Open Access Macedonian Journal of Medical Sciences 10, B (2022): 2225–29. http://dx.doi.org/10.3889/oamjms.2022.10794.

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Objective&#x0D; Allergic rhinitis is a symptomatic nasal disease provoked by exposure of the nasal mucosa to allergens, resulting in IgE-mediated inflammation. Swelling of the nasal mucosa is caused by interstitial mucosal edema due to leakage of plasma fluid and congestion of the nasal mucosal vessels and imbibition of the perivascular space. The method for determining the cross-sectional area as a function of airway distance is known as acoustic rhinometry. By using this approach, it is possible to determine the area as a function of the distance in the airways.&#x0D; Methods &#x0D; IL and I
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İNCE, İ̇skender, Gülbeyaz YILDIZ, Barış GÜMÜŞTAŞ, Cemal CİNGİ, and Yesim KARASULU. "Emulsion formulations of indomethacine and xylometazoline hydrochloride for intranasal delivery." Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi, December 21, 2020. http://dx.doi.org/10.18185/erzifbed.836484.

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21

Musmade, Bhaskar, Prashant Sanatan, Surbhi Lokhande, et al. "Development and validation of stability-indicating RP-HPLC method for the simultaneous estimation of xylometazoline hydrochloride and ipratropium bromide from nasal spray dosage form." Future Journal of Pharmaceutical Sciences 7, no. 1 (2021). http://dx.doi.org/10.1186/s43094-021-00247-x.

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Abstract Background A simple, robust, precise, and an accurate HPLC method was established for simultaneous estimation of xylometazoline hydrochloride and ipratropium bromide from a nasal spray dosage form. The effective separation was obtained by injecting 10 μl of sample and standard solutions on to an Inertsil ODS column, 250 × 4.6, mm, 5 μ at 45 °C using phosphate buffer with 1-pentane sulphonic acid sodium salt at pH 4.7 as a mobile phase A and acetonitrile as the mobile phase B. The gradient was optimized with a flow rate of 1 mL/min and a wavelength of 210.0 nm. Result The complete anal
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Dawood, Muhammad Hamza, Shanila Feroz, Sheza Sohail, Mavra Roshan, Haseefa Perveen, and Tasmiha Nizam. "Efficacy of 0.1% Xylometazoline-Hydrochloride Nasal Decongestant Spray in Postoperative Sign/Symptom Relief Following Septoplasty: A Randomized Control Trial." Ear, Nose & Throat Journal, July 30, 2024. http://dx.doi.org/10.1177/01455613241266473.

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Objective:This study evaluated the efficacy of 0.1% xylometazoline-hydrochloride nasal decongestant spray compared to 0.9% saline nasal spray in relieving post-septoplasty clinical nasal findings and symptoms. Methods: This triple-blinded randomized-clinical-trial was conducted in 2 tertiary-care hospitals in Karachi-Pakistan. A total of 120 septoplasty patients were recruited from June 20, 2022, to June 20, 2023. Randomly equally-assigned participants received either 0.9% isotonic-saline (control group) or 0.1% xylometazoline-hydrochloride (intervention group) nasal sprays. Participants were
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Sadiq, Wasan Jafar, and Imad Tarek Hanoon. "Using the zero-order derivative spectrum for the quantitative estimation of xylometazoline hydrochloride in its pure form and some of its pharmaceutical preparations." International journal of health sciences, June 16, 2022, 4168–74. http://dx.doi.org/10.53730/ijhs.v6ns4.9069.

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A new spectrophotometric method has been developed for the rapid, accurate and inexpensive determination of xylometazoline (XMH) in its pure form and in some pharmaceutical preparations, using the first derivative technique. It was found that this technique enables us to quantitatively estimate xylometazoline in a range of concentrations (5-50 µg.ml-1), the height of the peak above the base line of the wavelengths (268 and 292 nm) was taken advantage of. The obtained results showed that the method is accurate and has good agreement, as the percentage recovery was (95-100%), while the RSD value
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Tuncay Tanriverdi, Sakine, Evren Homan Gokce, Ivan Sušanj, et al. "Comprehensive evaluation of xylometazoline hydrochloride formulations: Ex-vivo and in-vitro studies." European Journal of Pharmaceutics and Biopharmaceutics, August 2024, 114466. http://dx.doi.org/10.1016/j.ejpb.2024.114466.

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Hristov, Danail Georgiev, Nikolina Petkova Milcheva, and Kiril Blazhev Gavazov. "Extraction-Chromogenic Systems for Vanadium(V) Based on Azo Dyes and Xylometazoline Hydrochloride." Acta Chimica Slovenica, December 18, 2019, 987–94. http://dx.doi.org/10.17344/acsi.2019.5244.

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26

Hagen, Martina, Kim Clark, Pranab Kalita, et al. "A real-world study of quality of life following treatment with xylometazoline hydrochloride in individuals with common cold." Therapeutic Advances in Respiratory Disease 18 (January 2024). http://dx.doi.org/10.1177/17534666241228927.

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Background: The common cold is a frequent, acute, and mild upper respiratory human disease. Nasal congestion has been considered the most bothersome symptom in the common cold, impacting quality of life (QoL). Topical decongestants containing steroids benefit QoL in allergic rhinitis, but no published research has assessed the impact of topical decongestants on QoL in the common cold. Objective: To evaluate the effects of xylometazoline hydrochloride 0.1% (Otrivin, GSK Consumer Healthcare SARL, Switzerland) for up to 7 days on QoL in participants with nasal congestion associated with the commo
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Racheva, Petya V., Nikolina P. Milcheva, Antoaneta D. Saravanska, and Kiril B. Gavazov. "Extraction of Gallium(III) with a New Azo Dye in The Presence or Absence of Xylometazoline Hydrochloride." Croatica Chemica Acta 93, no. 3 (2020). http://dx.doi.org/10.5562/cca3722.

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28

Helmecke, Gerd. ""Haemostasis with Xylometazoline Hydrochloride 1% (Trade Name Otriven) during Invasive Endoscopy an Alternative to the Usual Procedures"." Biomedical Journal of Scientific & Technical Research 56, no. 1 (2024). http://dx.doi.org/10.26717/bjstr.2024.56.008801.

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29

Samira, Nafi. "Montelukast, A Savior for Your Allergies – Could It Be the Reason for the Headaches and Mood Swings?" medtigo Journal of Neurology and Psychiatry 2, no. 2 (2025). https://doi.org/10.63096/medtigo3084223.

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Case Presentation A 42–year–old male presented at the outpatient clinic with breathing difficulty, productive cough, and nasal congestion. On examination, vitals were normal, the patient was lethargic, and on chest examination, there was bilateral air entry on both sides of the lung with no abnormal sounds. At the clinic, the patient improved on symptomatic treatment with Ventolin (Salbutamol) and Pulmicort (Budesonide) nebulization. He had a history of allergic rhinitis, which was well controlled on levocetrizine and montelukast for the past 1 year. The patient was stable at the time of disch
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