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1

Oge, Elizabeth N., Ernest Obese, Robert P. Biney, et al. "A review of pharmacological effects of xylopic acid." International Journal of Basic & Clinical Pharmacology 9, no. 5 (2020): 813. http://dx.doi.org/10.18203/2319-2003.ijbcp20201765.

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Xylopic acid (15β-acetyloxy-kaur-16-en-19-oic acid) is a kaurene diterpene that can be obtained from various Xylopia spp. Xylopic acid has demonstrated several pharmacological activities in vitro and in vivo. The compound has shown promising effect as a potent analgesic, anti-inflammatory and anti-allergic agent. Xylopic acid is a CNS depressant and was able to ameliorate anxiety-like symptoms in mice in addition to its neuroprotective effects. Deleterious effects of xylopic acid on the reproductive system of mice have been well documented but extensive toxicity study detailing effect of the a
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2

Osafo, Newman, David D. Obiri, Aaron O. Antwi, and Oduro K. Yeboah. "The acute anti-inflammatory action of xylopic acid isolated from Xylopia aethiopica." Journal of Basic and Clinical Physiology and Pharmacology 29, no. 6 (2018): 659–69. http://dx.doi.org/10.1515/jbcpp-2018-0019.

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AbstractBackgroundOur earlier studies had given evidence of the traditional application ofXylopia aethiopicain the management of inflammation. The principal constituent obtained from its bio-fractionation is xylopic acid. It is a crystalline diterpene that belongs to the class of kauranes. This work sets out to investigate the anti-inflammatory potential of the xylopic acid isolated from the dried fruit ofX. aethiopica.MethodsA preliminary anti-inflammatory study, using the protein denaturation model, andin vivoanti-inflammatory assay were employed in the investigation of acute inflammation. T
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3

Ameyaw, Elvis Ofori, Ernest Obese, Du-Bois Asante, et al. "Effect of xylopic acid on alloxan-induced diabetic neuropathy in rats." International Journal of Basic & Clinical Pharmacology 10, no. 4 (2021): 333. http://dx.doi.org/10.18203/2319-2003.ijbcp20211011.

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Background: Neuropathic pain is a very disturbing condition commonly found in diabetic patients. This study investigated xylopic acid (XA), the major constituent of Xylopia aethiopica in diabetic neuropathy as well as established possible toxicity of the compound on some selected tissues.Methods: Diabetes was induced in six groups of male rats with 120 mg/kg alloxan monohydrate. Diabetes was confirmed as a blood glucose level >15 mmol/dl. Neuropathic pain was confirmed on day three post-diabetes induction and treatment with 10 mg/kg, 30 mg/kg or 100 mg/kg xylopic acid, 10 mg/kg glibenclamid
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4

Boampong, J. N., E. O. Ameyaw, B. Aboagye, et al. "The Curative and Prophylactic Effects of Xylopic Acid onPlasmodium bergheiInfection in Mice." Journal of Parasitology Research 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/356107.

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Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana. Xylopic acid, a pure compound isolated from the fruits of theXylopia aethiopica,was investigated to establish its attributable prophylactic, curative antimalarial, and antipyretic properties. The antimalarial properties were determined by employing xylopic acid (10–100 mg/kg) in ICR mice infected withPlasmodium berghei. Xylopic acid exerted significant (P<0.05) effects onP. bergheiinfection similar
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5

Kofie, William, John Peter Fetse, and Reimmel Kwame Adosraku. "Antimicrobial Activities of Novel Xylopic Acid Derivatives." Journal of Advances in Microbiology 14, no. 1 (2019): 1–6. http://dx.doi.org/10.9734/jamb/2019/45824.

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6

Kofie, William, John Fetse, and Reimmel Adosraku. "Synthesis and Characterization of Novel Xylopic Acid Derivatives." American Chemical Science Journal 16, no. 2 (2016): 1–12. http://dx.doi.org/10.9734/acsj/2016/27962.

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7

Alolga, Raphael N., Assogba G. Assanhou, and Vitus Onoja. "QUANTIFICATION OF XYLOPIC ACID AND CHROMATOGRAPHIC FINGERPRINT EVALUATIONS OF THE DRIED FRUITS OF XYLOPIA AETHIOPICA FROM FOUR AFRICAN COUNTRIES." African Journal of Traditional, Complementary and Alternative Medicines 15, no. 3 (2018): 18. http://dx.doi.org/10.21010/ajtcamv15i3.2.

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Dunal) A. Rich, (herein called XYA), family Annonaceae, commonly known as “Guinea pepper”, “Ethiopian pepper” or “Negro pepper”, are widely used in traditional African medicines to treat a wide array of diseases including malaria, fungal infections, rheumatism, arthritis, etc. Scientific investigations have ascribed the following activities to the fruits of XYA; anti-diabetic, anti-inflammatory, antimicrobial, antiplasmodial, analgesic, anti-nociceptive, anti-proliferative, spermatogenic and neuropharmacological effects. The main active principle reported is xylopic acid (XA), a kaurene diterp
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8

Osafo, Newman, David Darko Obiri, Kwabena Owusu Danquah, Laslie Brian Essel, and Aaron Opoku Antwi. "Potential effects of xylopic acid on acetic acid-induced ulcerative colitis in rats." Turkish Journal of Gastroenterology 30, no. 8 (2019): 732–44. http://dx.doi.org/10.5152/tjg.2019.18389.

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9

Alolga, Raphael N., Assogba G. Assanhou, and Vitus Onoja. ") QUANTIFICATION OF XYLOPIC ACID AND CHROMATOGRAPHIC FINGERPRINT EVALUATIONS OF THE DRIED FRUITS OF XYLOPIA AETHIOPICA FROM FOUR AFRICAN COUNTRIES." African Journal of Traditional, Complementary and Alternative medicines 15, no. 3 (2018): 18–26. http://dx.doi.org/10.21010/ajtcam.v15i3.2.

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10

Osafo, N., and DD Obiri. "Anti-inflammatory and anti-anaphylactic activity of xylopic acid isolated from the dried fruit of Xylopia aethiopica in mice." Planta Medica 81, S 01 (2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1596165.

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11

Ameyaw, EO, JN Boampong, KE Kukuia, et al. "Effect of Xylopic Acid on Paclitaxel-induced Neuropathic pain in rats." Journal of Medical and Biomedical Sciences 2, no. 4 (2014): 6. http://dx.doi.org/10.4314/jmbs.v2i4.2.

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12

Osafo, Newman, Robert P. Biney, and David D. Obiri. "Aqueous Ethanol Fruit Extract of Xylopia aethiopica and Xylopic Acid Exhibit Anti-Inflammatory Activity through Inhibition of the Arachidonic Acid Pathway." UK Journal of Pharmaceutical Biosciences 4, no. 6 (2016): 49. http://dx.doi.org/10.20510/ukjpb/4/i6/134665.

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13

Woode, Eric, Elvis Ofori Ameyaw, Eric Boakye-Gyasi, et al. "Effects of an ethanol extract and the diterpene, xylopic acid, of Xylopia aethiopica fruits in murine models of musculoskeletal pain." Pharmaceutical Biology 54, no. 12 (2016): 2978–86. http://dx.doi.org/10.1080/13880209.2016.1199040.

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14

Tabekoueng, Georges Bellier, Carine Mvot Akak, Moses K. Langat, et al. "Chemical constituents from Penianthus camerounensis Dekker (Menispermaceae)." Zeitschrift für Naturforschung B 74, no. 10 (2019): 703–8. http://dx.doi.org/10.1515/znb-2019-0072.

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AbstractThe phytochemical study of the roots, leaves and twigs of Penianthus camerounensis Dekker (Menispermaceae) has led to the isolation and the characterization of 20 compounds. A ceramide, camerounamide (1), and a furoclerodanediterpenoid, camerounin (2), have not been described previously, while the compounds xylopic acid (3), syringaresinol (4), iso-propylmethylcyclohexa-1,4-diol (5), 1-(28-hydroxyoctacosanoyl)glycerol (6), scoparone (7), friedelin (8), friedelanol (9) and betulinic acid (10) are being reported for the first time from the genus Penianthus alongside 10 known compounds (1
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15

Biney, Robert, Charles Benneh, Donatus Adongo, and Eric Woode. "Rapid-onset anti-depressant-like potential of xylopic acid in mice and zebrafish." IBRO Reports 6 (September 2019): S487—S488. http://dx.doi.org/10.1016/j.ibror.2019.07.1531.

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16

Biney, Robert Peter, Charles Kwaku Benneh, Donatus Wewura Adongo, Elvis Ofori Ameyaw, and Eric Woode. "Evidence of an antidepressant-like effect of xylopic acid mediated by serotonergic mechanisms." Psychopharmacology 238, no. 8 (2021): 2105–20. http://dx.doi.org/10.1007/s00213-021-05835-6.

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17

Mante, Priscilla K., Adoley A. Mingle, Mustapha S. Kpienaan, Kweku Abakah-Ewusi, and Samuel Offei-Twum. "Xylopic acid prevents the development of tolerance and physical dependence to morphine in rats." Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (2018): PO1–1–87. http://dx.doi.org/10.1254/jpssuppl.wcp2018.0_po1-1-87.

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18

Woode, Eric, Elvis O. Ameyaw, George K. Ainooson, Wonder K. M. Abotsi, Eric Boakye-Gya, and James Oppong Kyekyeku. "Analgesic Effects of an Ethanol Extract of the Fruits of Xylopia aethiopica and Xylopic Acid in Murine Models of Pain: Possible Mechanism(s)." Pharmacologia 4, no. 4 (2013): 285–300. http://dx.doi.org/10.5567/pharmacologia.2013.285.300.

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19

Biney, Robert Peter, Charles Kwaku Benneh, James Oppong Kyekyeku, Elvis Ofori Ameyaw, Eric Boakye-Gyasi, and Eric Woode. "Attenuation of Anxiety Behaviours by Xylopic Acid in Mice and Zebrafish Models of Anxiety Disorder." UK Journal of Pharmaceutical Biosciences 6, no. 3 (2018): 7. http://dx.doi.org/10.20510/ukjpb/6/i3/173546.

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20

Ekuadzi, Edmund, Robert P. Biney, Charles K. Benneh, Bismark Osei Amankwaa, and Jonathan Jato. "Antiinflammatory properties of betulinic acid and xylopic acid in the carrageenan-induced pleurisy model of lung inflammation in mice." Phytotherapy Research 32, no. 3 (2017): 480–87. http://dx.doi.org/10.1002/ptr.5993.

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21

Woode, Eric, WonderK M. Abotsi, ReimmelK Adosraku, ElvisO Ameyaw, Eric Boakye-Gyasi, and JamesOppong Kyekyeku. "Anti-allodynic and Anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain." Pharmacognosy Research 6, no. 2 (2014): 172. http://dx.doi.org/10.4103/0974-8490.129041.

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22

Woode, Eric, ElvisO Ameyaw, Eric Boakye-Gyasi, and WonderK M. Abotsi. "Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine models." Journal of Pharmacy and Bioallied Sciences 4, no. 4 (2012): 291. http://dx.doi.org/10.4103/0975-7406.103251.

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23

Ekuadzi, Edmund, Robert P. Biney, Charles K. Benneh, Bismark Osei Amankwaa, and Jonathan Jato. "Anti-inflammatory properties of betulinic acid and xylopic acid in the carrageenan-induced pleurisy model of lung inflammation in mice." Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (2018): PO3–10–8. http://dx.doi.org/10.1254/jpssuppl.wcp2018.0_po3-10-8.

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24

Woode, Eric, ElvisOfori Ameyaw, WonderKofi Mensah Abotsi, and Eric Boakye-Gyasi. "An isobolographic analysis of the antinociceptive effect of xylopic acid in combination with morphine or diclofenac." Journal of Basic and Clinical Pharmacy 6, no. 4 (2015): 103. http://dx.doi.org/10.4103/0976-0105.168055.

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25

Ofori, Ameyaw Elvis, Woode Eric, Kyei Samuel, Biny Peter Robert, and Boampong Johnson Nyarko. "Anti-Nociceptive Synergism of Pregabalin and Xylopic acid Co-administration in Paclitaxel induced Neuropathy: Isobolographic Analysis." Pharmacognosy Journal 7, no. 6 (2015): 363–68. http://dx.doi.org/10.5530/pj.2015.6.8.

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26

Alolga, Raphael N., Yaw Opoku-Damoah, David A. Alagpulinsa, et al. "Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation." Biomaterials 268 (January 2021): 120482. http://dx.doi.org/10.1016/j.biomaterials.2020.120482.

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27

Herrera, Christiane Ribeiro Janner, Vanessa Rodrigues Vieira, Tiago Benoliel, et al. "Engineering Zymomonas mobilis for the Production of Xylonic Acid from Sugarcane Bagasse Hydrolysate." Microorganisms 9, no. 7 (2021): 1372. http://dx.doi.org/10.3390/microorganisms9071372.

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Sugarcane bagasse is an agricultural residue rich in xylose, which may be used as a feedstock for the production of high-value-added chemicals, such as xylonic acid, an organic acid listed as one of the top 30 value-added chemicals on a NREL report. Here, Zymomonas mobilis was engineered for the first time to produce xylonic acid from sugarcane bagasse hydrolysate. Seven coding genes for xylose dehydrogenase (XDH) were tested. The expression of XDH gene from Paraburkholderia xenovorans allowed the highest production of xylonic acid (26.17 ± 0.58 g L−1) from 50 g L−1 xylose in shake flasks, wit
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28

Ma, Jiliang, Dongnv Jin, Xiaopan Yang, Shaolong Sun, Jinghui Zhou, and Runcang Sun. "Phosphorus-doped carbon nitride with grafted sulfonic acid groups for efficient photocatalytic synthesis of xylonic acid." Green Chemistry 23, no. 11 (2021): 4150–60. http://dx.doi.org/10.1039/d1gc00920f.

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29

Yamabe, Shinichi, Noriko Tsuchida, Shoko Yamazaki, and Shigeyoshi Sakaki. "Frontier orbitals and transition states in the oxidation and degradation ofl-ascorbic acid: a DFT study." Organic & Biomolecular Chemistry 13, no. 13 (2015): 4002–15. http://dx.doi.org/10.1039/c5ob00035a.

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30

Zdraljevic, Stefan, Drew Wagner, Kevin Cheng, et al. "Single-Cell Measurements of Enzyme Levels as a Predictive Tool for Cellular Fates during Organic Acid Production." Applied and Environmental Microbiology 79, no. 24 (2013): 7569–82. http://dx.doi.org/10.1128/aem.01749-13.

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ABSTRACTOrganic acids derived from engineered microbes can replace fossil-derived chemicals in many applications. Fungal hosts are preferred for organic acid production because they tolerate lignocellulosic hydrolysates and low pH, allowing economic production and recovery of the free acid. However, cell death caused by cytosolic acidification constrains productivity. Cytosolic acidification affects cells asynchronously, suggesting that there is an underlying cell-to-cell heterogeneity in acid productivity and/or in resistance to toxicity. We used fluorescence microscopy to investigate the rel
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31

Buchert, J., L. Viikari, M. Linko, and P. Markkanen. "Production of xylonic acid byPseudomonas fragi." Biotechnology Letters 8, no. 8 (1986): 541–46. http://dx.doi.org/10.1007/bf01028079.

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32

NODA, Hiroko, and Masahiro OHSUGI. "D-Xylonic Acid Utilization by Bifidobacteria." Bifidobacteria and Microflora 14, no. 1 (1995): 15–17. http://dx.doi.org/10.12938/bifidus1982.14.1_15.

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33

Meng, Xintong, Zengyong Li, Di Li, et al. "Efficient base-free oxidation of monosaccharide into sugar acid under mild conditions using hierarchical porous carbon supported gold catalysts." Green Chemistry 22, no. 8 (2020): 2588–97. http://dx.doi.org/10.1039/c9gc04333k.

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34

Ma, Jiliang, Linxin Zhong, Xinwen Peng, and Runcang Sun. "d-Xylonic acid: a solvent and an effective biocatalyst for a three-component reaction." Green Chemistry 18, no. 6 (2016): 1738–50. http://dx.doi.org/10.1039/c5gc01727k.

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35

Wang, Chenhong, Dong Wei, Zhongxi Zhang, et al. "Production of xylonic acid by Klebsiella pneumoniae." Applied Microbiology and Biotechnology 100, no. 23 (2016): 10055–63. http://dx.doi.org/10.1007/s00253-016-7825-9.

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36

Bondar, Maryna, M. Manuela R. da Fonseca, and M. Teresa Cesário. "Xylonic acid production from xylose by Paraburkholderia sacchari." Biochemical Engineering Journal 170 (June 2021): 107982. http://dx.doi.org/10.1016/j.bej.2021.107982.

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37

Atchan Nwakiban, Achille Parfait, Stefania Cicolari, Stefano Piazza, et al. "Oxidative Stress Modulation by Cameroonian Spice Extracts in HepG2 Cells: Involvement of Nrf2 and Improvement of Glucose Uptake." Metabolites 10, no. 5 (2020): 182. http://dx.doi.org/10.3390/metabo10050182.

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Oxidative stress plays a relevant role in the progression of chronic conditions, including cardiometabolic diseases. Several Cameroonian plants, including spices, are traditionally used as herbal medicines for the treatment of diseases where oxidative stress contributes to insulin resistance, like type 2 diabetes mellitus. This study evaluated the antioxidant capacity and the effects on oxidative-stress-induced impairment of glucose uptake of 11 Cameroonian spice extracts. H2O2-induced reactive oxygen species (ROS) production by human HepG2 cells was significantly reduced by 8/11 extracts. The
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38

Takahashi, Jacqueline A., Maria Amélia D. Boaventura, Joaquim de Carvalho Bayma, and Oliveira Alaíde B. "Frutoic acid, a dimeric kaurane diterpene from Xylopia frutescens." Phytochemistry 40, no. 2 (1995): 607–9. http://dx.doi.org/10.1016/0031-9422(95)00264-8.

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39

Zdarta, Jakub, Karolina Bachosz, Oliwia Degórska, et al. "Co-Immobilization of Glucose Dehydrogenase and Xylose Dehydrogenase as a New Approach for Simultaneous Production of Gluconic and Xylonic Acid." Materials 12, no. 19 (2019): 3167. http://dx.doi.org/10.3390/ma12193167.

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The conversion of biomass components catalyzed via immobilized enzymes is a promising way of obtaining valuable compounds with high efficiency under mild conditions. However, simultaneous transformation of glucose and xylose into gluconic acid and xylonic acid, respectively, is an overlooked research area. Therefore, in this work we have undertaken a study focused on the co-immobilization of glucose dehydrogenase (GDH, EC 1.1.1.118) and xylose dehydrogenase (XDH, EC 1.1.1.175) using mesoporous Santa Barbara Amorphous silica (SBA 15) for the simultaneous production of gluconic acid and xylonic
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40

Tavares, Josean Fechine, Marianna Vieira B. Silva, Karine F. Queiroga, et al. "Xylodiol, a New Atisane Diterpenoid from Xylopia Langsdorffiana St.-Hil. & Tul. (Annonaceae)." Zeitschrift für Naturforschung B 62, no. 5 (2007): 742–44. http://dx.doi.org/10.1515/znb-2007-0520.

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Abstract Two diterpenes were isolated from the leaves of Xylopia langsdorffiana, the new ent-atisane- 7α,16α-diol named xylodiol (1) and the known 8 (17),12E,14-labdatrien-18-oic acid (2). The structures of these isolates were deduced by spectroscopic data interpretation. Compound 2was less toxic than xylodiol on V79 cells and hepatocytes.
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41

Cavalcanti, B. C., J. R. O. Ferreira, D. J. Moura, et al. "Structure–mutagenicity relationship of kaurenoic acid from Xylopia sericeae (Annonaceae)." Mutation Research/Genetic Toxicology and Environmental Mutagenesis 701, no. 2 (2010): 153–63. http://dx.doi.org/10.1016/j.mrgentox.2010.06.010.

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42

Jokic, A., N. Ristic, M. M. Jaksic, M. Spasojevic, and N. Krstajic. "Simultaneous electrolytic production of xylitol and xylonic acid from xylose." Journal of Applied Electrochemistry 21, no. 4 (1991): 321–26. http://dx.doi.org/10.1007/bf01020216.

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43

Zhu, Junjun, Yayun Rong, Jinlong Yang, et al. "Integrated Production of Xylonic Acid and Bioethanol from Acid-Catalyzed Steam-Exploded Corn Stover." Applied Biochemistry and Biotechnology 176, no. 5 (2015): 1370–81. http://dx.doi.org/10.1007/s12010-015-1651-x.

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44

Lee, Charles C., Rena E. Kibblewhite, Chad D. Paavola, William J. Orts, and Kurt Wagschal. "Production of D-Xylonic Acid from Hemicellulose Using Artificial Enzyme Complexes." Journal of Microbiology and Biotechnology 27, no. 1 (2017): 77–83. http://dx.doi.org/10.4014/jmb.1606.06041.

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45

Hummel, Michael, Mikko Leppikallio, Sami Heikkinen, Klaus Niemelä, and Herbert Sixta. "Acidity and Lactonization of Xylonic Acid: A Nuclear Magnetic Resonance Study." Journal of Carbohydrate Chemistry 29, no. 8-9 (2010): 416–28. http://dx.doi.org/10.1080/07328303.2011.567424.

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46

TAKAHASHI, J. A., M. A. D. BOAVENTURA, J. DE CARVALHO BAYMA, and A. B. OLIVEIRA. "ChemInform Abstract: Frutoic Acid, a Dimeric Kaurane Diterpene from Xylopia frutescens." ChemInform 27, no. 3 (2010): no. http://dx.doi.org/10.1002/chin.199603190.

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47

Yim, Sung Sun, Jae Woong Choi, Se Hwa Lee, Eun Jung Jeon, Wook-Jin Chung, and Ki Jun Jeong. "Engineering ofCorynebacterium glutamicumfor Consolidated Conversion of Hemicellulosic Biomass into Xylonic Acid." Biotechnology Journal 12, no. 11 (2017): 1700040. http://dx.doi.org/10.1002/biot.201700040.

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48

Zhou, Xuelian, Xin Zhou, Guang Liu, Yong Xu, and Venkatesh Balan. "Integrated production of gluconic acid and xylonic acid using dilute acid pretreated corn stover by two-stage fermentation." Biochemical Engineering Journal 137 (September 2018): 18–22. http://dx.doi.org/10.1016/j.bej.2018.05.005.

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49

Hasan, Choudhury M., Terence M. Healey, and Peter G. Waterman. "Acutifloric acid: A diterpene dimer from the stem bark of Xylopia acutiflora." Phytochemistry 24, no. 1 (1985): 192–94. http://dx.doi.org/10.1016/s0031-9422(00)80841-9.

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50

O. O, Okwari,, Dasofunjo K, Obembe A.O, Olatunji T.L, and Osim, E. E. "Xylopia aethiopica fruit extract lowers uric acid levels in wistar albino rats." IOSR Journal of Pharmacy and Biological Sciences 9, no. 1 (2014): 46–50. http://dx.doi.org/10.9790/3008-09124650.

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