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Hou, Thomas Y. "A brief introduction to Theodore Yao-Tsu Wu." Notices of the International Congress of Chinese Mathematicians 4, no. 1 (2016): 55–61. http://dx.doi.org/10.4310/iccm.2016.v4.n1.a7.
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li, Xiaolin, Yufei Liu, and Weimo Zhu. "Effects Of Wu-bi-shan-yao Decoction On Exercise-induced Fatigue." Medicine & Science in Sports & Exercise 47 (May 2015): 193. http://dx.doi.org/10.1249/01.mss.0000476950.56051.bc.
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Xiao, Jin Rong. "The Garment Dyeing Technology and Folk Culture of Wuling Miao-Yao Branch." Advanced Materials Research 1048 (October 2014): 322–27. http://dx.doi.org/10.4028/www.scientific.net/amr.1048.322.
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This paper studies the clothing color and dyeing technology of Wu Ling Miao-Yao, and discussing its relevant folk culture. From the perspective of geographical and climatic conditions, analysis the dyeing of raw material on the Miao Yao languages colored clothing. From the view of folk custom and technology, analysis the characteristics of garment dyeing technology and the process flow, especially the process of blue dress color which represents the main color of clothing, through the one by one explaining of the preparation of dyes, dye, indigo dyeing, after preparation consolidation of color, summing up the folk culture connotation of clothing color, aiming at exploring the plant dye resources, protecting the traditional folk culture, maintain the sustainable development of ecological environment.
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WU, Peichen. "Traveling Japan, Writing Japan：The Translation and Publishing of the Travelogue Wareteki Nihon." Border Crossings: The Journal of Japanese-Language Literature Studies 13, no. 1 (December 30, 2021): 53–60. http://dx.doi.org/10.22628/bcjjl.2021.13.1.53.
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The travelogue Wareteki Nihon was published in December 2018 by Hakushui Sha, and included the work of eighteen Taiwanese writers from various generations. All their works in the text relate to their travels in Japan. These Taiwanese writers are Kan Yao-Ming, Ko Yu-fen, Huang Li-Chun, Wang Sheng-Hong, Jiang E, Chen Bo-Chin, Hu Mu-Ching, Sheng Hao-We, Chu He-Chih, Wu Ming-Yi, Lu Hui-Hsin, Yi Ge-Yan, Yen Shu-Hsia, and Liu Shu-Hui, whose works in this anthology depict Japanese scenery, culture and literature, and so on. This paper will focus on how this publishing project started, the process of producing this travelogue, and the evaluations and responses of Japan’s literary circle and the mass media to it after its publication in Japan.
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MO, RAORAO, HAO LIU, FANBIN KONG, and WEIHAI LI. "Review of the genus Cerconychia Klapálek, 1913 (Plecoptera: Styloperlidae), with description of C. multiseta sp. nov." Zootaxa 5040, no. 4 (September 23, 2021): 582–88. http://dx.doi.org/10.11646/zootaxa.5040.4.8.
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Species of the genus Cerconychia (Plecoptera: Pteronarcyoidea: Styloperlidae) are reviewed. A new species, C. multiseta sp. nov. is described from Cenwanglaoshan Mountain of western Guangxi Zhuang Autonomous Region, China. The new species is compared with related congeners. Complementary description or brief taxonomic comments are presented for C. brunnea Klapálek, 1913, C. flectospina Wu, 1962, C. livida Klapálek, 1913, C. sinensis Yang & Yang, 1995 and C. trilobata Mo, Yao, Wang & Li, 2019.
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Lee, Ga-young. "The significance methods of Kinmen Island in Wu Jun-Yao"s 『Kinmen』." JOURNAL OF CHINESE HUMANITIES 80 (April 30, 2022): 253–72. http://dx.doi.org/10.35955/jch.2022.04.80.253.
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Schröder, Sven, Kathrin Beckmann, Giovanna Franconi, Gesa Meyer-Hamme, Thomas Friedemann, Henry Johannes Greten, Matthias Rostock, and Thomas Efferth. "Can Medical Herbs Stimulate Regeneration or Neuroprotection and Treat Neuropathic Pain in Chemotherapy-Induced Peripheral Neuropathy?" Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–18. http://dx.doi.org/10.1155/2013/423713.
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Chemotherapy-induced neuropathy (CIPN) has a relevant impact on the quality of life of cancer patients. There are no curative conventional treatments, so further options have to be investigated. We conducted a systematic review in English and Chinese language databases to illuminate the role of medical herbs. 26 relevant studies on 5 single herbs, one extract, one receptor-agonist, and 8 combinations of herbs were identified focusing on the single herbsAcorus calamus rhizoma,Cannabis sativa fructus,Chamomilla matricaria,Ginkgo biloba,Salvia officinalis,Sweet bee venom,Fritillaria cirrhosae bulbus,and the herbal combinations Bu Yang Huan Wu, modified Bu Yang Huan Wu plus Liuwei Di Huang, modified Chai Hu Long Gu Mu Li Wan,Geranii herbaplusAconiti lateralis praeparata radix, Niu Che Sen Qi Wan (Goshajinkigan), Gui Zhi Jia Shu Fu Tang (Keishikajutsubuto), Huang Qi Wu Wu Tang (Ogikeishigomotsuto), and Shao Yao Gan Cao Tang(Shakuyakukanzoto). The knowledge of mechanism of action is still limited, the quality of clinical trials needs further improvement, and studies have not yielded enough evidence to establish a standard practice, but a lot of promising substances have been identified. While CIPN has multiple mechanisms of neuronal degeneration, a combination of herbs or substances might deal with multiple targets for the aim of neuroprotection or neuroregeneration in CIPN.
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MO, RAORAO, GUOQUAN WANG, DING YANG, WEIHAI LI, and DÁVID MURÁNYI. "Two new species and four unknown larvae of Amphinemurinae (Plecoptera, Nemouridae) from southern China." Zootaxa 5040, no. 1 (September 20, 2021): 77–101. http://dx.doi.org/10.11646/zootaxa.5040.1.4.
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Two new nemourid species, Amphinemura meizhouensis sp. n. and A. tulipa sp. n., are described from Guangdong Province and Guangxi Zhuang Autonomous Region, respectively. Four larvae of the stonefly subfamily Amphinemurinae, A. bifascia Mo, Wang, Yang & Li, 2020, A. hamiornata Li & Yang, 2008, A. yao Mo, Yang, Wang & Li, 2017, and Indonemoura scalprata (Li & Yang, 2007) are described and illustrated on the basis of recently collected specimens from southern China. The female adult of A. hamiornata is also described from the type locality. Both new species are typical members of the A. sinensis (Wu, 1926) species group and the taxonomic relationships are discussed with related congeners.
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Murray, Judson B. "A Study of “Yao Lue” 要略, “A Sumary of the Essentials”: TheHuainanzi淮南子 from the Point of View of the Postface." Early China 29 (2004): 45–109. http://dx.doi.org/10.1017/s0362502800007094.
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TheHuainanziis a Former Han 前漢 dynasty (202 B.C.E.–9 C.E.) compendium of knowledge written at the court of Huainan and presented to Emperor Wu of the Han 漢武帝 in 139 by Liu An 劉安 (?179–122), the king of Huainan. Liu An was the grandson of the Han “progenitor” Gaozu 高祖 (Liu Bang 劉邦 r. 202–195), and he was the uncle of the reigning emperor Wu (r. 140–87). According to the author(s) of the text’s postface, “Yao lue” 要略 or “A Summary of the Essentials,” the work seeks to provide a comprehensive account or chronicle of thedao道 (conventionally translated as the “Way”), understood broadly to encompass the cosmos (tiandi天地 or “Heaven and Earth”), human beings (ren人) and their affairs (shi事), and the relationship between them. The account of thedaopresented in its chapters is not, however, purely descriptive. TheHuainanziis foremost a political treatise containing instructions worthy of a sage-king (shengwang聖王) to be employed by the ruler as the proper model or standard by which to govern the empire.
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Torkian, Faezeh, Mohsen Arefi, and Mohammad Ghasem Akbari. "Multivariate Least Squares Regression using Interval-Valued Fuzzy Data and based on Extended Yao-Wu Signed Distance." International Journal of Computational Intelligence Systems 7, no. 1 (October 28, 2013): 172–85. http://dx.doi.org/10.1080/18756891.2013.859867.
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Fan, AY. "The first acupuncture center in the United States: an interview with Dr. Yao Wu Lee, Washington Acupuncture Center." Journal of Chinese Integrative Medicine 10, no. 5 (May 15, 2012): 481–92. http://dx.doi.org/10.3736/jcim20120502.
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Wu, Yongjiang, Yunliang Zheng, Xuesong Liu, Zheng Han, Yiping Ren, Lishe Gan, Changxin Zhou, and Lianjun Luan. "Separation and quantitative determination of sesquiterpene lactones in Lindera aggregata (Wu-yao) by ultra-performance LC-MS/MS." Journal of Separation Science 33, no. 8 (February 24, 2010): 1072–78. http://dx.doi.org/10.1002/jssc.200900768.
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Niu, Xuyang, Yuxiang Ma, Xiaozhou Ma, Guohai Dong, and Yongbo Song. "AN EXPERIMENTAL STUDY OF EXTREME WAVE KINEMATICS ON OPPOSING DEPTH-VARYING CURRENTS." Coastal Engineering Proceedings, no. 36 (December 30, 2018): 37. http://dx.doi.org/10.9753/icce.v36.waves.37.
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In the past decades, there are numerous reports on the accidents caused by extremely large waves. A large number of papers have contributed to the study on the physical properties and the generation mechanisms of such large waves. However, most of the research has been carried out without presence of currents. In the real ocean, the waves most likely coexist with currents. In many circumstances, owing to wind force and oceanic circulation, the currents are commonly not uniform and vary with depth, which plays an important role in the evolution of gravity waves (Swan et al., 2001). Wave kinematics is a key factor in designing structures. However, experimental studies of the influence of depth-varying currents on extreme waves are mainly considered for the changing of spatial and temporal geometric characteristics (Yao and Wu, 2006). In the present study, the kinematics of extreme waves on opposing depth-varying currents will be investigated using the PIV technology.
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Yao, Xin. "Simulated Evolution and Learning." Journal of Advanced Computational Intelligence and Intelligent Informatics 4, no. 2 (March 20, 2000): 129. http://dx.doi.org/10.20965/jaciii.2000.p0129.
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Evolution and learning are two fundamental forms of adaptationl,2). Simulated evolution and learning refers to the study of techniques and methods inspired by Nature for solving complex and difficult real-world problems. These techniques and methods include evolutionary algorithms3), fuzzy learning algorithms, neural learning algorithms, and various statistical learning methods such as nearest neighbor classifiers. In addition to various learning tasks, these techniques and methods have also been applied to various difficult optimization problems that cannot be solved effectively by classical methods (such as mathematical programming methods). This special issue contains six papers selected from those presented at the Second Asia-Pacific Conference on Simulated Evolution And Learning (SEAL'98), Canberra, Australia, 24-27 November 1998. However, all six papers have been rereviewed and substantially extended and revised. They represent significant improved work from their original SEA L'98 papers. The six papers can be grouped into three categories. The first two papers by He et al. and by Ishibuchi and Nakashima described novel applications of genetic algorithms to nearest neighbor classifiers. The next two papers by Kawakami et al. and by Tachibana and Furuhashi presented new fuzzy learning systems. The last two papers by Myung and Kim and by Yu and Wu discussed constrained optimization using the evolutionary approach. I would like to take this opportunity to thank Dr Bob McKay, the SEAL'98 Organizing Committee Chair, for playing a pivotal role in organizing the very successful SEAL'98, Professor Kaoru Hirota, the Editor-in-Chief of the Journal of Advanced Computational Intelligence, for encouraging me to edit this special issue, and all the authors for their high-quality work. References: 1)X. Yao, J-H. Kim, and T. Furuhashi, eds., Simulated Evolution and Learning, Vol. 1285 of Lecture Notes in Artificial Intelligence. Berlin, Germany: Springer-Verlag, 1997. 2)B. Mckay, X. Yao, C. S. Newton, J-H. kim, and T. Furuhashi, eds., Simulated Evolution and Learning, Vo1.1585 of Lecture Notes in Artificial Intelligence. Berlin, Germany: Springer-Verlag, 1999. 3)X. Yao, ed., Evolutionary Computation: Theory and Applications. Singapore: World Scientific Publishing Co., 1999.
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Liao, Yueh-Hsiang, Jaung-Geng Lin, Cheng-Chieh Lin, Chin-Chuan Tsai, Hui-Lien Lai, and Tsai-Chung Li. "Traditional Chinese Medicine Treatment Associated with Female Infertility in Taiwan: A Population-Based Case-Control Study." Evidence-Based Complementary and Alternative Medicine 2020 (December 12, 2020): 1–11. http://dx.doi.org/10.1155/2020/3951741.
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Background. Traditional Chinese medicine (TCM) for the treatment of female infertility remains ambiguous. The aim of the present case-control study was to examine the association between TCM treatment and successful pregnancy among infertile women. Methods. This population-based case-control study included the data from 2,627 infertile women with successful pregnancy and 2,627 infertile women without successful pregnancy using datasets from the Longitudinal Health Insurance Database 2000 of the National Health Insurance Research Database during 2000–2010. The odds ratios (ORs) and 95% confidence intervals (CIs) for the relationship between TCM use and successful pregnancy in infertility women were estimated using logistic regression. Results. Patients who received TCM treatment significantly increased in successful pregnancy (OR = 1.48; 95% CI = 1.31–1.66), compared with patients without TCM. Si-Wu-Tang (OR = 4.25; 95% CI = 2.18, 8.30), Gui-Zhi-Fu-Ling-Wan (OR = 3.27; 95% CI = 2.13, 5.02), and Jia-Wei-Xiao-Yao-San (OR = 3.17; 95% CI = 2.35, 4.28) were the TCM agents that were most strongly associated with successful pregnancy among infertile women. Conclusions. Our study findings indicate that TCM is associated with higher likelihood of successful pregnancy in infertile women, which is worthy of further investigation by randomized control trial.
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Park, Jihyeon, and Jaeyoung Lee. "Performance Prediction of Alkaline Fuel Cell Via Gradient Boosting Algorithm." ECS Meeting Abstracts MA2022-01, no. 35 (July 7, 2022): 1508. http://dx.doi.org/10.1149/ma2022-01351508mtgabs.
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With the DFT theory at the forefront, non-PGM catalysts have begun to develop, and in much literature, results have shown that the performance of non-PGM catalysts is comparable to that of PGM catalysts. Jing et. al. synthesized Fe-Co dual sites on nitrogen-doped carbon for oxygen reduction reaction (ORR). (FeCo)/N-C had almost equal half-wave potential to commercial Pt/C.[1] Hanguang et. al. achieved high ORR-activated Fe-N-C catalysts by tuning the doped Fe content and active sites.[2] However, if both (FeCo)/N-C and Fe-N-C were applied to PEMFC, they were not comparable to PGM catalysts unlike in the results of the half-cell test. This discrepancy means that numerous factors should be considered and optimized in a practical system like a fuel cell. Besides, it is indicated that even if the DFT theory and deep-learning combine to suggest catalysts with high performance, it may not produce as much performance in the actual fuel cell system as expected. In this respect, the combination of fuel cell systems (not catalysts) and artificial intelligence (AI) seems more reasonable. Without human judgment or intervention, machine learning sets priorities between each index by learning from many databases. Herein, we newly developed an optimization model for alkaline liquid fuel cell (Hydrazine fuel cell) using gradient boosting algorithm (XGBoost) which is one of machine learning algorithms. We operated fuel cells in various conditions by changing humidity of cathode, back pressure of cathode, cell temperature, stoichiometric factor (air/fuel), and concentration of the fuel. And then, we categorized and classified with the specific algorithm. Finally, we re-organized and set as a function of weight which effects on fuel cell operation. We hope that these approach will help improve fuel cell performance by controlling a number of factors without human intervention. [1] J. Wang, Z. Huang, W. Liu, C. Chang, H. Tang, Z. Li, W. Chen, C. Jia, T. Yao, S. Wei, Y. Wu, Y. Li, J. Am. Chem. Soc. 139 (2017) 17281–17284. [2] H. Zhang, H.T. Chung, D.A. Cullen, S. Wagner, U.I. Kramm, K.L. More, P. Zelenay, G. Wu, Energy Environ. Sci. 12 (2019) 2548–2558.
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Mo, Chia-Kuei, Yige Wu, Terekhanova Nadezhda, Caravan Wagma, Preet Lal, Siqi Chen, Nataly Naser AL Deen, et al. "Abstract 2025: Spatial transcriptomic profiling of progression markers in clear cell renal cell carcinoma." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2025. http://dx.doi.org/10.1158/1538-7445.am2022-2025.
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Abstract Next-generation sequencing enabled molecular landscaping and the discovery of novel tumor markers in ccRCC. However, the spatial relationships and histological features of the tumor microenvironment were lost during this process. Combining snRNA-seq, snATAC-seq, Spatial Transcriptomics (ST) technology, and immunofluorescence labeling, we discovered novel ccRCC progression tumor markers, and uncovered their spatial dependent expression pattern in both human ccRCC tumors and patient-derived xenograft (PDX). Using snRNA-seq and snATAC-seq, novel tumor progression markers such as NDRG1, MGST1, ABCC3 and PCSK6 were discovered, and their expressions were validated in ST. We found that one of the key novel tumor markers, CP, exhibited specific spatial expression patterns on tissue slides. The elevation of CP expression region is associated with a higher degree of hyalinization in ccRCC human tumor samples. Similarly, using immunofluorescence labeling, we validated the co-expression of CP and PCSK6 canonical ccRCC marker CA9. Overall, this study revealed novel ccRCC progression markers and linked their spatial expression pattern with histological features. Citation Format: Chia-Kuei Mo, Yige Wu, Terekhanova Nadezhda, Caravan Wagma, Preet Lal, Siqi Chen, Nataly Naser AL Deen, Ruiyang Liu, Yanyan Zhao, Kazuhito Sato, Lijun Yao, Mamatha Serasanambati, Andrew Shinkle, Reyka G. Jayasinghe, Li Ding, Feng Chen. Spatial transcriptomic profiling of progression markers in clear cell renal cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2025.
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Cheng, Ying, Jie Wang, Caicun Zhou, Wenxiu Yao, Qiming Wang, Xuhong Min, Gongyan Chen, et al. "Abstract CT038: Adebrelimab or placebo plus carboplatin and etoposide as first-line treatment for extensive-stage SCLC: A phase 3 trial." Cancer Research 82, no. 12_Supplement (June 15, 2022): CT038. http://dx.doi.org/10.1158/1538-7445.am2022-ct038.
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Abstract Introduction: Extensive-stage small cell lung cancer (ES-SCLC) is associated with limited treatment options and poor prognosis. Immunotherapy has recently showed robust clinical activity in ES-SCLC. In this double-blind, phase 3 trial, we evaluated adebrelimab (SHR-1316), a novel anti-PD-L1 antibody, in combination with standard chemotherapy (chemo) as first-line treatment for ES-SCLC. Methods: Patients naïve to systemic treatment for ES-SCLC were randomized 1:1 to receive 4-6 cycles of adebrelimab (20 mg/kg, iv, d1, q3w) or placebo with carboplatin (AUC 5, d1, q3w) plus etoposide (100 mg/m2, d1, d2, d3, q3w), followed by maintenance therapy with adebrelimab or placebo. The primary endpoint was overall survival (OS). Results: 462 patients were randomized and treated (adebrelimab+chemo, n=230; placebo+chemo, n=232). As of Oct 08, 2021, with an median follow-up of 13.5 mo (all patients; 22.5 mo for patients alive), OS was significantly prolonged with adebrelimab+chemo vs placebo+chemo (median, 15.3 mo [95% CI 13.2-17.5] vs 12.8 mo [95% CI 11.3-13.7]; hazard ratio [HR], 0.72 [95% CI 0.58-0.90], 1-sided p=0.0017); OS rate was 62.9% vs 52.0% at 12 mo and 31.3% vs 17.2% at 24 mo. Progression-free survival (PFS) per independent review committee (IRC) was 5.8 mo (95% CI 5.6-6.9) with adebrelimab+chemo vs 5.6 mo (95% CI 5.5-5.7) with placebo+chemo (HR 0.67, 95% CI 0.54-0.83); PFS rate was 49.4% vs 37.3% at 6 mo and 19.7% vs 5.9% at 12 mo. Objective response rate (ORR) and duration of response (DoR) also favored the adebrelimab+chemo group (Table 1). Grade ≥3 treatment-related adverse events occurred in 85.7% vs 84.9% of patients with adebrelimab+chemo vs placebo+chemo, with the most common (frequency ≥5%) being hematological toxicities in both groups. Conclusions: The addition of adebrelimab to chemotherapy significantly improved OS with an acceptable safety profile, supporting this combination as a new first-line treatment option for ES-SCLC. Efficacy outcomes Adebrelimab+Chemo (n=230) Placebo+Chemo (n=232) Median OS (95% CI), mo 15.3 (13.2-17.5) 12.8 (11.3-13.7) HR (95% CI)*, 1-sided log-rank p 0.72 (0.58-0.90); p=0.0017 12-mo OS rate (95% CI), % 62.9 (56.3-68.8) 52.0 (45.4-58.2) 24-mo OS rate (95% CI), % 31.3 (24.9-37.9) 17.2 (12.1-23.0) Median PFS (95% CI), mo 5.8 (5.6-6.9) 5.6 (5.5-5.7) HR (95% CI)*, 1-sided log-rank p 0.67 (0.54-0.83); p <0.0001 6-mo PFS rate (95% CI), % 49.4 (42.4-56.0) 37.3 (30.7-43.9) 12-mo PFS rate (95% CI), % 19.7 (14.5-25.5) 5.9 (3.1-10.1) IRC-assessed ORR (95% CI), % 70.4 (64.1-76.3) 65.9 (59.5-72.0) Median DoR (95% CI), mo 5.6 (4.6-6.7) 4.6 (4.3-5.5) *Stratified Cox proportional-hazards model Citation Format: Ying Cheng, Jie Wang, Caicun Zhou, Wenxiu Yao, Qiming Wang, Xuhong Min, Gongyan Chen, Xingxiang Xu, Xingya Li, Fei Xu, Yong Fang, Runxiang Yang, Guohua Yu, Youling Gong, Jun Zhao, Yun Fan, Quan Liu, Lejie Cao, Yu Yao, Yunpeng Liu, Xiaoling Li, Jingxun Wu, Zhiyong He, Kaihua Lu, Liyan Jiang, Huiqing Yu, Chengping Hu, Wenhua Zhao, Jian Zhao, Gang Wu, Dingzhi Huang, Chengshui Chen, Cuimin Ding, Baihong Zhang, Xiuwen Wang, Hui Luo, Baolan Li, Ben Zhang, Haowen Li, Ke Ma. Adebrelimab or placebo plus carboplatin and etoposide as first-line treatment for extensive-stage SCLC: A phase 3 trial [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT038.
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오순방. "Study on Domesticating Translation Strategies of Chinese Christian Translation Fictions in Late Qing Dynasty, Hong Zhu Ru Zhuan, Yu Dao Yao Zhi and Wu Geng Zhong." Journal of Study on Language and Culture of Korea and China ll, no. 39 (October 2015): 299–330. http://dx.doi.org/10.16874/jslckc.2015..39.012.
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KURIHARA, Shinji, Katsuhiko YASHIRO, Masahiro CHATANI, Koji YAGI, and Toshiaki NAKAZAWA. "A COMPARISON OF SPATIAL ORGANIZATION AND HIERARCHICAL ORDER OF PLACE BETWEEN TRADITIONAL CAVE DWELLINGS (YAO-DONG) AND DWELLINGS ABOVE GROUND (FANG-WU) : Spatial organization and hierarchical order of place in Yao-Dong settlement dwellings of Chinese Loess Land Part I." Journal of Architecture, Planning and Environmental Engineering (Transactions of AIJ) 454 (1993): 45–53. http://dx.doi.org/10.3130/aijax.454.0_45.
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Chen, Wen, Hsing-Yu Chen, Yao-Hsu Yang, Sien-Hung Yang, Ching-Wei Yang, You-Hung Wu, and Jiun-Liang Chen. "An Investigation of the Prescription Patterns of Chinese Herbal Products for Chronic Glomerulonephritis Patients: A Hospital-Based Cross-Sectional Study." Evidence-Based Complementary and Alternative Medicine 2018 (November 15, 2018): 1–11. http://dx.doi.org/10.1155/2018/5080764.
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Chronic kidney disease (CKD) has a high incidence and prevalence worldwide, and chronic glomerulonephritis (CGN) is one of the main causes of CKD. Therefore, it is important to diagnose and treat CGN early. The purpose of this study is to analyze the prescription patterns and frequencies of Chinese herbal products (CHPs) for CGN by using a hospital-based database from the Chang Gung Memorial Hospital (CGMH), a large, tertiary hospital system in Taiwan, and to evaluate the safety and possible efficacy of CHPs by blood test. The International Classification of Disease Ninth Revision (ICD-9) code 582 was used to identify patients with CGN. From 2004 to 2015, a total of 54726 CHP prescriptions for CGN were provided. Association rule mining was used to analyze the prevalent of CHP combination patterns in treating CGN. Jia-Wei-Xiao-Yao-San (JWXYS) and Gorgon (Euryale feroxSalisb.) were the most frequently prescribed herbal formula (HF) and single herb (SH), respectively. The most frequently prescribed combination of CHPs was that of JWXYS with Bu-Yang-Huan-Wu-Tang (BYHWT) in CGMH. In statistical, the level of eGFR in Stage 3a and 3b group was increasing after treatment in 6 and 12 months and might not cause the renal function to worsen within 12-month treatments. To the best of our knowledge, this is the first pharmacoepidemiological study to review CHP treatments for CGN. However, additional studies and clinical trials are needed to provide data on the safety and efficacy of these CHPs.
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Feng, Huimin, You Chen, Bo Li, and Yaoting Wu. "Molecular phylogeny of genus Musa determined by simple sequence repeat markers." Plant Genetic Resources 14, no. 3 (August 12, 2015): 192–99. http://dx.doi.org/10.1017/s1479262115000222.
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Musa L. was previously separated into five sections (Eumusa, Rhodochlamys, Callimusa, Australimusa and Ingentimusa) based on basic chromosome numbers and morphological characters. However, several molecular analyses currently support restructuring of Musa species into two sections, Musa and Callimusa. The application of simple sequence repeat molecular marker analysis to Musa phylogeny provided valuable, supplemental information about the classification of, and relationships between, Musa species and subspecies. Totally, 28 accessions of Musa acuminata Colla subspecies and varieties and 25 accessions of other Musa species were evaluated; 12 primers produced 91 polymorphic bands, polymorphic information content ranged from 0.4473 to 0.8394 (average = 0.7226), indicating that the primers showed a high level of polymorphism. Our results generally agreed with previous phylogenetic analyses based on molecular data. One clade comprised species of sections Australimusa and Callimusa (X= 10/9); most species of sections Eumusa and Rhodochlamys (X= 11) formed the other clade. The relationships between most species were as expected; however, some species did not conform to findings of previous studies. A wide range of variability was observed in the M. acuminata complex. M. acuminata var. chinensis and M. acuminata subsp. 522 showed the most distant relationships to other subspecies: Musa laterita, Musa ornata and Musa velutina clustered with M. acuminata var. chinensis, suggesting that they may constitute a secondary gene pool for the improvement of cultivated bananas. Molecular data indicated that Musa tongbiguanensis Chen You & Yao-Ting Wu, which was observed and described by our research group in Yunnan, China, was a distinct, new species.
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Chen, Huiting, Shiyu Wei, Weitian Ding, Han Wei, Liang Li, Henrik Saxén, Hongming Long, and Yaowei Yu. "Interfacial Area Transport Equation for Bubble Coalescence and Breakup: Developments and Comparisons." Entropy 23, no. 9 (August 25, 2021): 1106. http://dx.doi.org/10.3390/e23091106.
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Bubble coalescence and breakup play important roles in physical-chemical processes and bubbles are treated in two groups in the interfacial area transport equation (IATE). This paper presents a review of IATE for bubble coalescence and breakup to model five bubble interaction mechanisms: bubble coalescence due to random collision, bubble coalescence due to wake entrainment, bubble breakup due to turbulent impact, bubble breakup due to shearing-off, and bubble breakup due to surface instability. In bubble coalescence, bubble size, velocity and collision frequency are dominant. In bubble breakup, the influence of viscous shear, shearing-off, and surface instability are neglected, and their corresponding theory and modelling are rare in the literature. Furthermore, combining turbulent kinetic energy and inertial force together is the best choice for the bubble breakup criterion. The reviewed one-group constitutive models include the one developed by Wu et al., Ishii and Kim, Hibiki and Ishii, Yao and Morel, and Nguyen et al. To extend the IATE prediction capability beyond bubbly flow, two-group IATE is needed and its performance is strongly dependent on the channel size and geometry. Therefore, constitutive models for two-group IATE in a three-type channel (i.e., narrow confined channel, round pipe and relatively larger pipe) are summarized. Although great progress in extending the IATE beyond churn-turbulent flow to churn-annual flow was made, there are still some issues in their modelling and experiments due to the highly distorted interface measurement. Regarded as the challenges to be addressed in the further study, some limitations of IATE general applicability and the directions for future development are highlighted.
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Subanakov, Alexey K., Evgeniy V. Kovtunets, Sampil Zh Choydonov, Sesegma G. Dorzhieva, and Bair G. Bazarov. "Синтез и характеризация нового двойного бората рубидия–гольмия Rb3HoB6O12." Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, no. 2 (June 14, 2019): 278–86. http://dx.doi.org/10.17308/kcmf.2019.21/765.
Full textAbstract:
Методом цитратной золь-гель технологии получен новый двойной борат рубидия–гольмия состава Rb3HoB6O12. Соединение кристаллизуется в тригональной сингонии (пр. гр. R32, a = 13.4038(7), с = 30.315(2) Å, V = 4716.76 Å3) и плавится инконгруэнтно при 818 °С. Попытки получить в однофазном состоянии Rb3HoB6O12 методом твердофазных реакций не привели к положительному результату
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Atuchin V. V., Subanakov A. K., Aleksandrovsky A. S., Bazarov B. G., Bazarova J. G., Dorzhieva S. G., Gavrilova T. A., Krylov A. S., Molokeev M. S., Oreshonkov A. S., Pugachev A. M., Tushinova Yu. L., Yelisseyev A. P. Exploration of structural, thermal, vibrational and spectroscopic properties of new noncentrosymmetric double borate Rb3NdB6O12 // Powder Technol., 2017, v. 28, pp. 1309–1315. https://doi.org/10.1016/j.apt.2017.02.019
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de Wit, M. C. "Re: Detection of submicroscopic chromosomal aberrations by array-based comparative genomic hybridization in fetuses with congenital heart disease. Y. Yan, Q. Wu, L. Zhang, X. Wang, S. Dan, D. Deng, L. Sun, L. Yao, Y. Ma and L. Wang. Ultrasound Obstet Gyne." Ultrasound in Obstetrics & Gynecology 43, no. 4 (April 2014): 363. http://dx.doi.org/10.1002/uog.13355.
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Liu, Wenxian, Linwei Lu, Cheng Ma, Chen Yan, Zhengxiao Zhao, Nabijan Mohammadtursun, Lingli Hu, et al. "The evolution of Traditional Chinese Medicine as a disciplinary concept and its essence throughout history." Traditional Medicine and Modern Medicine 01, no. 03 (September 2018): 171–80. http://dx.doi.org/10.1142/s257590001810002x.
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“Traditional Chinese Medicine” (TCM; Zhong Yi) is a concept that keeps evolving with the change of times and clinical practice. From the aspect of the category of modern science, there were not appropriate boundaries set for the literature, history and philosophy in the realm of Chinese traditional academics. Thanks to the eastward spread of Western culture and science, the category of disciplines in modern times then came into being. In order to be listed in the system of modern disciplines, traditional disciplines have always been trying to redefine themselves, and “TCM,” of course, is involved. Considering the fact that “TCM” is now an academic discipline in the field of medicine, here we reviewed not only the transition of the concept of “TCM” from a primitive and then a hierarchical medical term to a relatively full-fledged one that is, to some extent, opposite to the concept of Western Medicine or modern medicine, from a narrow medical term that is peculiar to Han Medicine to a broad one that pertains to Han Medicine along with ethnic traditional medicines in China, but also the transition of the development from merely highlighting TCM and then equally emphasizing TCM together with modern medicine to comprehensively converging TCM, modern medicine and Integrative Medicine, which contributes to the evolution from the dominance of TCM, the coexistence of TCM and modern medicine, the confluence of TCM and modern medicine, and finally to the integration of TCM and modern medicine. In addition, we introduced pioneering medical concepts, epistemology and methodology such as Chinese Traditional Medicine (CTM; Da Zhong Yi), Trichotomy (San Fen Fa), Five Key Elements (Wu Yao Su) and Three-dimensional Integration (San Rong He), proposed the potential future direction of medicine, stressed the importance of taking the essence and discarding the dregs in TCM, and appreciated those who are able to perceive similarities in differences. We looked forward to reconstructing the system of TCM by the integration of the part that is unconsciously ahead of modern medicine and that has already reached consensus with modern medicine from all the traditional medicines in China, which would promise a brand new system of medicine harmoniously integrating traditional medicine and modern medicine.
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Storrs, Erik, Daniel Cui Zhou, Michael C. Wendl, Matthew A. Wyczalkowski, Alla Karpova, Liang-Bo Wang, Yize Li, et al. "Abstract 1932: Pollock: Fishing for cell states." Cancer Research 82, no. 12_Supplement (June 15, 2022): 1932. http://dx.doi.org/10.1158/1538-7445.am2022-1932.
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Abstract The use of single-cell methods is expanding at an ever-increasing rate. While multiple algorithms address the task of cell classification, they are limited in terms of cross platform compatibility, reliance on the availability of a reference dataset, and classification interpretability. Here, we introduce Pollock, a suite of algorithms for cell type identification that is compatible with popular single cell methods and analysis platforms, provides a series of pretrained human cancer reference models, and reports interpretability scores that identify the genes that drive cell type classifications. Our model combines two important approaches, one each from machine learning and deep learning: a variational autoencoder (VAE) and random forest classifier, to make cell type predictions. Pollock is highly versatile, being available as a command line tool, Python library (with scanpy integration), or R library (with Seurat integration), and can be installed as a conda package, or in containerized form via Docker. To allow for easier pan-disease and pan-tissue analyses, Pollock also ships with a library of pretrained cancer type specific and agnostic modules that were trained on expertly-curated single cell data that are ready to “plug and play” with no additional annotation or training required. Conversely, Pollock also allows for the training of custom classification modules, if an annotated reference single cell dataset is available. These pretrained models were fitted on manually curated and annotated single cell data from eight different cancer types spanning three single cell technologies (scRNA-seq, snRNA-seq, and snATAC-seq). Pollock also provides feature importance scores that allow for cell type classifications to be traced back to the genes influencing a particular cell type classification, further promoting biological interpretability. These scores could allow for new, technology-specific biomarker discovery. We also demonstrate the utility of Pollock by applying it in a pan-cancer single cell immune analysis. Citation Format: Erik Storrs, Daniel Cui Zhou, Michael C. Wendl, Matthew A. Wyczalkowski, Alla Karpova, Liang-Bo Wang, Yize Li, Austin Southard-Smith, Reyka G. Jayasinghe, Lijun Yao, Ruiyang Liu, Yige Wu, Nadezhda V. Terekhanova, Houxiang Zhu, John M. Herndon, Feng Chen, William E. Gillanders, Ryan C. Fields, Li Ding. Pollock: Fishing for cell states [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1932.
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Ping, Yuan. "(Invited) Effect of Polaron Formation on Optical and Carrier Transport Properties of Transition Metal Oxides As Photoelectrodes from First-Principles Calculations." ECS Meeting Abstracts MA2022-02, no. 48 (October 9, 2022): 1843. http://dx.doi.org/10.1149/ma2022-02481843mtgabs.
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Transition metal oxides are promising photoelectrode materials for solar-to-fuel conversion applications. However, their performance is limited by the low carrier mobility (especially electron mobility) due to the formation of small polarons. Recent experimental studies have shown improved carrier mobility and conductivity by atomic doping; however the underlying mechanism is not understood. A fundamental atomistic-level understanding of the effects on small polaron transport is critical to future material design with high conductivity. In this talk, we will discuss the effect of small polaron formation on optical and carrier transport properties of transition metal oxides from first-principles calculations. First, we resolve the conflicting findings that have been reported on the optical gap of a well-known catalysis Co3O4 as an example[1]. We confirm that the formation of small hole polarons significantly influences the optical absorption spectra and introduces extra spectroscopic signature below the intrinsic band gap, leading to a 0.8 eV transition that is often misinterpreted as the band edge that defines the fundamental gap. Then we discuss the formation of small polarons' effect on carrier concentration, by resolving the controversy of nature of "shallow" or "deep" impurities of intrinsic oxygen vacancies in BiVO4 as an example[2], i.e. how to unify different experiments with the correct definition of ionization energy in polaronic oxides. We further discuss why certain dopants can have very low optimal concentrations (or very early doping bottleneck) in polaronic oxides such as Fe2O3, through a novel "electric-multipole" clustering between dopants and polarons[3]. These multipoles can be very stable at room temperature and are difficult to fully ionize compared to separate dopants, and thus they are detrimental to carrier concentration improvement. This allows us to uncover mysteries of the doping bottleneck in hematite and provide guidance for optimizing doping and carrier conductivity in polaronic oxides toward highly efficient energy conversion applications. In addition, we show the importance of synthesis condition such as synthesis temperature and oxygen partial pressure on dopant and polaron concentrations, and how to optimize the synthesis condition based on theoretical predictions[4]. At the end, we show different theoretical models for polaron mobility calculations from a macroscopic dielectric continuum picture with an example of spin polarons in CuO[5] and a microscopic polaron hopping picture by combining generalized Landau-Zener theory and kinetic Monte-Carlo samplings for doped oxides[6]. Our first-principles calculations provide important insights and suggest design principles for optimal optical and transport properties of polaronic oxides. References: [1] “Optical Absorption Induced by Small Polaron Formation in Transition Metal Oxides – The Case of Co3O4”, T. Smart, T. Pham, Y. Ping*, and T. Ogitsu*, Physical Review Materials (Rapid Communications), 3, 102401(R), (2019). [2] “The Role of Point Defects in Enhancing the Conductivity of BiVO4”, H. Seo, Y. Ping and G. Galli*, Chemistry of Materials, 30, 7793, (2018). [3] “Doping Bottleneck in Hematite: Multipole Clustering by Small Polarons”, T. Smart, V. Baltazar, M. Chen, B. Yao, K. Mayford, F. Bridges, Y. Li, and Y. Ping*, Chemistry of Materials, 33, 4390, (2021). [4] “The Critical Role of Synthesis Conditions on Small Polaron Carrier Concentrations in Hematite- A First-Principles Study”, Tyler Smart, Mingpeng Chen, Valentin Urena Baltazar, Frank Bridges, Yat Li, Yuan Ping*, under review, (2021). [5]“Mechanistic Insights of Enhanced Spin Polaron Conduction in CuO through Atomic Doping”, T. Smart, A. Cardiel, F. Wu, K. Choi and Y. Ping*, npj Computational Materials, 4, 61, (2018). [6] “Combining Landau-Zener Theory and Kinetic Monte Carlo Sampling for Small Polaron Mobility of Doped BiVO4 from First-principles”, F. Wu and Y. Ping*, Journal of Materials Chemistry A, 6, 20025, (2018).
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Shin, Sang yong, and Hyunjoo Lee. "Synthesis of Single-Atom and Dual-Atom Catalyst Using N-Defective C3N4." ECS Meeting Abstracts MA2022-02, no. 54 (October 9, 2022): 2021. http://dx.doi.org/10.1149/ma2022-02542021mtgabs.
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Single-atom catalysts, which have been studied tremendously in the past decade, are emerging as a new class of heterogeneous catalysts. It is now generally known that defect sites play an important role in forming single-atomic structures. In the case of SACs, defective sites provide not only space for fixation of metal precursor, but also electrons for stabilizing positive metal ions. Graphitic carbon nitride (g-C3N4) is one of the ideal 2D materials for the synthesis of SACs. C3N4 has enough anchoring sites which originate from the ordered structure of tri-s-triazines connected together. Furthermore, abundant nitrogen atoms in C3N4 can provide electrons to single metal atoms. however, C3N4 is unsuitable as support for electrochemical catalysts due to its low electrical conductivity. Therefore, we made a C3N4 shell on the outer surface of carbon black (Ketjen Black EC-600JD) to obtain conductive support (C@C3N4).[1] Pt was supported on C@C3N4 at 1, 2, 4, and 8 wt% by wetness impregnation method. Through XRD, HAADF-STEM, and XAFS analysis, it was confirmed that a single-atomic structure was formed only when the Pt content was 1 or 2 wt%. In addition, I confirmed that the H2O2 selectivity (%) in the electrochemical oxygen reduction reaction was different according to the Pt content of the catalysts. In terms of controlling reaction sites at the atomic level, the challenge above creating single-atomic structures is creating structures in which two or three atoms are formed as dimer or trimer. Unlike single-atom catalysts, in a dimer or trimer structure, two or more atoms are adjacent to each other, so they can exhibit completely different catalytic properties. Finely controlling the defect site of the support can be a good strategy. Therefore, I adopted the strategy of making a defect in C3N4 to synthesize a dimer structure. It has been reported that N-vacancy can be selectively formed on C3N4 by additional heat treatment with NaBH4.[2, 3] In addition, DFT calculation results have been reported that Pd-Cu dimer structure can be stably formed on nitrogen-defective C3N4.[4] In this work, I create N-vacancy on a Pt1/C@C3N4 by additional heat treatment with NaBH4, and Co atoms were deposited as a secondary transition metal. The research strategy was to anchor the Co atom to the N-vacancy formed around the Pt single-atom, resulting in the formation of a dimer structure. First of all, the formation of N-vacancy on C@C3N4 support was clearly confirmed by FT-IR and XPS analysis. To confirm the dimer structure of Pt and Co, XAFS analysis was conducted. As a result, although not all Pt and Co atoms formed a dimer structure due to the limitation of the synthesis method, the intended structure of Co atom connected to a Pt atom was confirmed. In the Pt L3 edge EXAFS, a peak arising from Pt-Co scattering was observed at 2.4 Å. Furthermore, to confirm that PtCo alloy particles were not formed, high-result HAADF-STEM images were taken. All metal atoms were atomically dispersed, and nanoparticles were not found. This research demonstrated that defect engineering on support material can successfully modify active site on the atomic scale. References [1] Lee, I. H.; Cho, J.; Chae, K. H.; Cho, M. K.; Jung, J.; Cho, J.; Lee, H. J.; Ham, H. C.; Kim, J. Y., Appl. Catal. B, 2018, 237, 318-326. [2] Wen, Y.; Qu, D.; An, L.; Gao, X.; Jiang, W.; Wu, D.; Yang, D.; Sun, Z., ACS Sustain. Chem. Eng. 2019, 7 (2), 2343-2349. [3] Yu, H.; Shi, R.; Zhao, Y.; Bian, T.; Zhao, Y.; Zhou, C.; Waterhouse, G. I. N.; Wu, L.-Z.; Tung, C.-H.; Zhang, T., Adv. Mater. 2017, 29 (16), 1605148. [4] Cao, Y.; Zhao, C.; Fang, Q.; Zhong, X.; Zhuang, G.; Deng, S.; Wei, Z.; Yao, Z.; Wang, J., J. Mater. Chem. A, 2020, 8 (5), 2672-2683.
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Fernández Vidal, Julia, Thomas Galloway, Gary Attard, and Laurence J. Hardwick. "Cation Size Effect on Oxygen Reduction Reaction in Aprotic Electrolytes." ECS Meeting Abstracts MA2022-01, no. 4 (July 7, 2022): 577. http://dx.doi.org/10.1149/ma2022-014577mtgabs.
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The most important cathodic process in alkali metal-air (M-O2) batteries is the electrocatalytic oxygen reduction reaction (ORR) typically forming superoxide (MO2), and peroxide (M2O2).1 Cation size in aqueous solvents have been demonstrated to affect the ORR activity due to the cation hydration energy.2 However, within aprotic electrolytes, the reaction mechanisms and the activity of ORR with respect to cation size remains undetermined. Traditionally, electrochemistry has been involved in the analysis of the reaction mechanisms of ORR. Nonetheless, this technique by itself is not suitable to identify intermediaries and products of the redox reactions taking place at the electrochemical interface. The combination of cyclic voltammetry with in situ Raman spectroscopy provide the opportunity to study and develop a fundamental understanding of the ORR under potential control, accessing reaction pathways and relating them directly to surface structure.3 In this sense, the breakthrough of Shell-Isolated Nanoparticles for Enhanced Raman Spectroscopy (SHINERS)4,5 is noteworthy. SHINERS is a non-destructive, powerful technique for surface analysis that has been demonstrated to provide SERS effect even in the absence of intrinsic roughness and without requiring Au, Ag or Cu to be used as working electrodes.3,5 In this work, electrochemical measurements and SHINERS are utilised to study the effect of cation upon electrified interfaces during ORR. Zhang, J., Zhang, X.-G., Dong, J.-C., Radjenovic, P. M., Young, D. J., Yao, J.-L., Yuan, Y.-X., Tian, Z.-Q. & Li, J.-F. Real-Time Monitoring of Surface Effects on the Oxygen Reduction Reaction Mechanism for Aprotic Na–O2 Batteries. J. Am. Chem. Soc. 143, 20049–20054 (2021). Kumeda, T., Tajiri, H., Sakata, O., Hoshi, N. & Nakamura, M. Effect of hydrophobic cations on the oxygen reduction reaction on single‒crystal platinum electrodes. Nat. Commun. 9, 1–7 (2018). Guan, S., Attard, G. A. & Wain, A. J. Observation of Substituent Effects in the Electrochemical Adsorption and Hydrogenation of Alkynes on Pt{hkl} Using SHINERS. ACS Catal. 10, 10999–11010 (2020). Li, J. F., Huang, Y. F., Ding, Y., Yang, Z. L., Li, S. B., Zhou, X. S., Fan, F. R., Zhang, W., Zhou, Z. Y., Wu, D. Y., Ren, B., Wang, Z. L. & Tian, Z. Q. Shell-isolated nanoparticle-enhanced Raman spectroscopy. Nature 464, 392–395 (2010). Galloway, T. A., Dong, J.-C., Li, J.-F., Attard, G. & Hardwick, L. J. Oxygen reactions on Pt{hkl} in a non-aqueous Na+ electrolyte: site selective stabilisation of a sodium peroxy species. Chem. Sci. 10, 2956–2964 (2019).
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Wu, Wei, and Greg M. McFarquhar. "Reply to “What Is the Maximum Entropy Principle? Comments on ‘Statistical Theory on the Functional Form of Cloud Particle Size Distributions’”." Journal of the Atmospheric Sciences 76, no. 12 (December 1, 2019): 3961–63. http://dx.doi.org/10.1175/jas-d-18-0374.1.
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Abstract We welcome the opportunity to correct the misunderstandings and misinterpretations contained in Yano’s comment that led him to incorrectly state that Wu and McFarquhar misunderstood the maximum entropy (MaxEnt) principle. As correctly stated by Yano, the principle itself does not suffer from the problem of a lack of invariance. But, as restated in this reply and in Wu and McFarquhar, the commonly used Shannon–Gibbs entropy does suffer from a lack of invariance for coordinate transform when applied in continuous cases, and this problem is resolved by the use of the relative entropy. Further, it is restated that the Wu and McFarquhar derivation of the PSD form using MaxEnt is more general than the formulation by Yano and allows more constraints with any functional relations to be applied. The derivation of Yano is nothing new but the representation of PSDs in other variables.
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Gao, Yue, Chun-Jie Liu, Hua-Yi Li, Xiao-Ming Xiong, Sjors G. j. g. In ‘t Veld, Gui-Ling Li, Jia-Hao Liu, et al. "Abstract LB168: Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study." Cancer Research 82, no. 12_Supplement (June 15, 2022): LB168. http://dx.doi.org/10.1158/1538-7445.am2022-lb168.
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Abstract Background: Morpho-physiological alternations of platelets provided a rationale to harness RNA sequencing of tumor-educated platelets (TEPs) for preoperative diagnosis of cancer. Timely, accurate, and non-invasive detection of ovarian cancer in women with adnexal masses presents a significant clinical challenge. Patients and Methods: This intercontinental, hospital-based, diagnostic study included 761 treatment-naïve inpatients with histologically confirmed adnexal masses and 167 healthy controls from nine medical centers (China, n=3; Netherlands, n=5; Poland, n=1) between September 2016 and May 2019. The main outcomes were the performance of TEPs and their combination with CA125 in two Chinese (VC1 and VC2) and the European (VC3) validation cohorts collectively and independently. Exploratory outcome was the value of TEPs in public pan-cancer platelet transcriptome datasets. Results: The AUCs for TEPs in the combined validation cohort, VC1, VC2, and VC3 were 0.918 (95% CI 0.889-0.948), 0.923 (0.855-0.990), 0.918 (0.872-0.963), and 0.887 (0.813-0.960), respectively. Combination of TEPs and CA125 demonstrated an AUC of 0.922 (0.889-0.955) in the combined validation cohort; 0.955 (0.912-0.997) in VC1; 0.939 (0.901-0.977) in VC2; 0.917 (0.824-1.000) in VC3. For subgroup analysis, TEPs exhibited an AUC of 0.858, 0.859, and 0.920 to detect early-stage, borderline, non-epithelial diseases and 0.899 to discriminate ovarian cancer from endometriosis. Analysis of public datasets suggested that TEPs had potential to detect multiple malignancies (Table 1). Conclusions: TEPs had robustness, compatibility, and universality for preoperative diagnosis of ovarian cancer since it withstood validations in populations of different ethnicities, heterogeneous histological subtypes, early-stage ovarian cancer as well as other malignancies. However, these observations warrant prospective validations in a larger population before clinical utilities. Table 1. Performance for TEPs in public pan-cancer datasets. Disease n Healthy Control AUC, area under the curve (95% CI) Women NSCLC (non-small-cell lung cancer) 126 77 0.758 (0.691-0.825) Breast cancer 38 77 0.817 (0.726-0.909) Colorectal cancer 18 77 0.973 (0.945-1.000) Pancreatic cancer 16 77 0.993 (0.981-1.000) Glioblastoma 10 77 0.923 (0.831-1.000) Men NSCLC 119 82 0.746 (0.677-0.815) Colorectal cancer 25 82 0.933 (0.884-0.982) Pancreatic cancer 22 82 0.993 (0.984-1.000) Glioblastoma 19 82 0.981 (0.959-1.000) All NSCLC 245 159 0.774 (0.728-0.820) Colorectal cancer 40 159 0.978 (0.961-0.996) Breast cancer 38 159 0.821 (0.736-0.906) Pancreatic cancer 35 159 0.987 (0.974-0.999) Glioblastoma 35 159 0.931 (0.890-0.972) Hepatobiliary carcinomas 14 159 0.991 (0.978-1.000) Citation Format: Yue Gao, Chun-Jie Liu, Hua-Yi Li, Xiao-Ming Xiong, Sjors G.j.g. In ‘t Veld, Gui-Ling Li, Jia-Hao Liu, Guang-Yao Cai, Gui-Yan Xie, Shao-Qing Zeng, Yuan Wu, Jian-Hua Chi, Qiong Zhang, Xiao-Fei Jiao, Lin-Li Shi, Wan-Rong Lu, Wei-Guo Lv, Xing-Sheng Yang, Jurgen M.j. Piek, Cornelis D de Kroon, C.a.r. Lok, Anna Supernat, Sylwia Łapińska-Szumczyk, Anna Łojkowska, Anna J. Żaczek, Jacek Jassem, Bakhos A. Tannous, Nik Sol, Edward Post, Myron G. Best, Bei-Hua Kong, Xing Xie, Ding Ma, Thomas Wurdinger, An-Yuan Guo, Qing-Lei Gao. Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB168.
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Xie, Hui, Wei Li, Yufeng Yao, Sujie Ni, Tongbo Yi, Jinling Cheng, Qi Fang, et al. "Abstract P2-13-41: First-line pyrotinib plus trastuzumab and nab-paclitaxel for patients with HER2-positive advanced breast cancer." Cancer Research 82, no. 4_Supplement (February 15, 2022): P2–13–41—P2–13–41. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-13-41.
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Abstract Background: Overexpression of human epidermal factor receptor 2 (HER2) is seen in 15-20% of breast cancer and results in more aggressive clinical behavior and poor prognosis. This study (ChiCTR2000030618) analyzed the efficacy and safety of pyrotinib plus trastuzumab and nab-paclitaxel in patients with previously untreated HER2-positive locally recurrent or metastatic breast cancer.Methods: Patients with previously untreated HER2-positive locally recurrent or metastatic breast cancer received pyrotinib (400 mg, qd), trastuzumab (H, 8 mg/kg loading dose, followed by 6 mg/kg every 3 weeks) and nab-paclitaxel (260 mg/m² every 3 weeks) until disease progression or an unacceptable adverse event (AE). The primary endpoint was progression-free survival (PFS). Secondary endpoints included objective response rate (ORR), disease control rate (DCR), overall survival (OS), and AEs.Results: A total of 28 patients (median age: 55.5 years [28-78]) were enrolled from April 2020 to June 2021. All 28 patients (100%) had Eastern Cooperative Oncology Group performance status of 1. The metastatic sites were in brain (14.29%), liver (25.00%), bone (28.57%) and lung (53.57%). HR+ and HR- for primary tumor accounted for 57.14% and 42.86%, respectively. Trastuzumab was previously administered in the (neo)adjuvant setting to 17(60.71%) patients. Eight patients with measurable lesions were evaluable for response. 5 (62.50%) patients had partial response (PR) and 3 (37.50%) patients achieved stable disease (SD), resulting in an ORR of 62.50% and DCR of 100.00%. Median PFS has not yet been reached. Twenty-one patients were included in the safety assessments. The most common AE was diarrhea (85.71%), but only 3 (14.29%) patients reported Grade ≥ 3 diarrhea which could be well controlled. The median onset of diarrhea was 1.5 days after start of treatment and the median duration was 9 days. Most diarrhea events were reported during the first cycle of treatment and the frequency persistently declined in the following cycles. Moreover, the AEs of all grades that were documented in ≥20% of patients included leukopenia (28.57%), anemia (23.81%), thrombocytopenia (19.05%), γ-glutamyltransferase increased (19.05%), vomiting (19.05%), rash (19.05%) and alanine aminotransferase increased (19.05%). No treatment-related deaths were reported.Conclusion: Pyrotinib plus trastuzumab and nab-paclitaxel showed promising efficacy in first-line HER2-positive breast cancer and were well tolerated. More data would be analyzed and reported in the future. Citation Format: Hui Xie, Wei Li, Yufeng Yao, Sujie Ni, Tongbo Yi, Jinling Cheng, Qi Fang, Lei Zhang, Jun Zhou, Xiaohong Wu, Chunbin Wang, Yanan Zhang, Jianwei Qin, Qing Shao, Tao Zhao, Xiaohong Huang, Lingyun Xu. First-line pyrotinib plus trastuzumab and nab-paclitaxel for patients with HER2-positive advanced breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-13-41.
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김지영. "The Study of Gu Yan-wu Poetry." Journal of Foreign Studies ll, no. 46 (December 2018): 437–60. http://dx.doi.org/10.15755/jfs.2018..46.437.
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Liu, Xiaochang, Jiuxia Pang, Christopher Seiler, Ryan Kempen, Hao Liu, Aref Al-Kali, Y. Natalia Tretyakova, Mark Litzow, and Shujun Liu. "DNA Cytosine-Demethylating Agent 5-Aza-2'-Deoxycytidine Targets Leukemia Cells through Reducing DNA N6-Methyladenine." Blood 134, Supplement_1 (November 13, 2019): 2513. http://dx.doi.org/10.1182/blood-2019-130490.
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Introduction: It is known that overexpression of DNA methyltransferases (e.g., DNMT1) is frequent and changes of DNA cytosine methylation (5mC) are a constant feature of cancers. DNA methylation inhibitors, such as 5-aza-2'-deoxycytidine (Dec), have been in clinics for patients with leukemia. It is classically believed that promoter hypomethylation coupled by reexpression of epigenetically-suppressed tumor suppressors is a core mechanism behind Dec-impaired leukemia cell growth. However, the fact that global DNA methylation profiling barely predicts Dec-response suggests a demethylation-independent mechanism of Dec-induced cell death. N6-methyladenine (m6A) has been identified recently as an abundant DNA modification in eukaryotes (Wu, Nature 2016;532:329). Importantly, m6A is extensively present in the human genome, and m6A abundance is associated with tumorigenesis (Xie, Cell 2018;71:306). Furthermore, the DNA m6A is dynamically modulated by the methyltransferases (i.e., METTL3, N6AMT1) and demethylases (i.e., ALKBH1), and changes in m6A predict gene expression (Wu, Nature 2016;532:329). Given a potential crosstalk between m6A and distinct epigenetic mechanisms (Yao, Nat. Commun 2017;8:1122), we hypothesized that the anticancer actions of Dec may partially result from changes in DNA m6A in leukemia cells. Methods: Protein expression of target genes was assessed by Western blotting. The levels of DNA cytosine methylation (5mC) and N6-methyladenine (m6A) were measured by dotblotting or liquid chromatography-mass spectrometry (LC-MS/MS). The cell viability and apoptosis were determined by the Cell Counting Kit 8 (CCK8) assays as well as the Annexin V/Propidium Iodide staining and flow cytometry. The peripheral blood mononuclear cells (PBMCs) of leukemia patients from Mayo Clinic were prepared by Ficoll-Hypaque gradient centrifugation. Results: To test our hypothesis, leukemia cells, Kasumi-1, MV4-11, K562 and KU812, were exposed to 2 µM Dec, a clinical achievable concentration, for 72 hours. As expected, Dec treatment led to a downregulation of DNMT1 and DNMT3a, a reduction of 5mC levels by dotblotting using anti-5mC antibody, a blockage of cell proliferation and a promotion of cell apoptosis. When genomic DNA was subjected to dotblotting using anti-m6A antibody, the results revealed a marked decrease of DNA m6A levels in all Dec-treated cells. Then genomic DNA from K562 and MV4-11 cells was enzymatically digested to 2'-deoxynucleosides. dA was quantified by HPLC-UV, while the amount of m6A was measured by isotope dilution HPLC-ESI-MS/MS using 15N labeled internal standard. The standard curves were generated using pure standards, from which the m6A/A ratio was calculated. In agreement with dotblotting results, Dec treatment significantly decreased DNA m6A abundance in both cell lines. Mechanistically, exposure to Dec led to a consistent increase of demethylase fat mass and obesity-associated protein (FTO), but not METTL3 nor ALKBH1 and ALKBH5. Further, knockdown of FTO increased DNA m6A, which was further confirmed by treatment with FTO inhibitors rhein and meclofenamic acid (MA). These data indicate that FTO may be responsible for Dec-induced m6A changes in leukemia cells. To investigate the clinical implications of DNA m6A, we obtained PBMCs from AML patients (n = 10), who received Dec therapy (20 mg/m2 daily for 5 days every 4 weeks) in Mayo Clinic. These PBMCs were further cultured for 48 hours, frozen and stored in 100% ethanol before DNA extraction. The results from dotblotting using anti-5mC or anti-m6A showed that a trend of decrease in both m6A and 5mC abundance is observed, and the pattern of changes in m6A and 5mC displays a positive correlation. Finally, exposure of leukemia cells to the combination of Dec (2 µM) with FTO inhibitor MA (50 µM) induced more cell apoptosis and greater inhibition on cell proliferation as compared to single agent in vitro, supporting FTO inhibitors as new therapeutic agents in leukemia. Conclusion: Our studies suggest that the FTO-DNA m6A axis may partially mediate the therapeutic outcomes of Dec in leukemia. Our findings provide a new mechanistic paradigm for the anticancer activities of Dec, and define the m6A methylation status in leukemia cells as a new pharmacodynamic marker for their response to Dec-based therapy, pointing to a novel treatment strategy for incorporating m6A modulators to enhance the therapeutic index of Dec. Disclosures Al-Kali: Astex Pharmaceuticals, Inc.: Research Funding.
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Wu, Yan, Yu Huang, Chunlai Tu, Fengren Wu, Gangsheng Tong, Yue Su, Li Xu, Xiaoqin Zhang, Shuqiang Xiong, and Xinyuan Zhu. "Correction: A mesoporous polydopamine nanoparticle enables highly efficient manganese encapsulation for enhanced MRI-guided photothermal therapy." Nanoscale 14, no. 12 (2022): 4770. http://dx.doi.org/10.1039/d1nr90265b.
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Correction for ‘A mesoporous polydopamine nanoparticle enables highly efficient manganese encapsulation for enhanced MRI-guided photothermal therapy’ by Yan Wu et al., Nanoscale, 2021, 13, 6439–6446, DOI: D1NR00957E.
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Aljedani, Jabr, Michael J. Chen, and Barry J. Cox. "Analysing the stability of graphene wrinkles using variational calculus." ANZIAM Journal 63 (July 4, 2022): C97—C109. http://dx.doi.org/10.21914/anziamj.v63.17079.
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The chemical vapour deposition method is widely used to synthesise high quality graphene with a large surface area. However, the cooling process leads to the formations of ripples and wrinkles in the graphene structure. When a self-adhered wrinkle achieves the maximum height, it then folds onto the surface and leads to a collapsed wrinkle. The presence of such deformations often affects the properties of graphene. In this article, we describe a novel mathematical model to understand the formation and geometry of these wrinkles. The stability of these wrinkles is examined based on variational derivations for the energy of each structure. The model provides detailed explanations for the geometry of these wrinkles which would help in tuning their properties. References J. Aljedani, M. J. Chen, and B. J. Cox. Variational model for collapsed graphene wrinkles. Appl. Phys. A 127.11, 886 (2021), pp. 1–13. doi: 10.1007/s00339-021-05000-y A. A. Balandin, S. Ghosh, W. Bao, I. Calizo, D. Teweldebrhan, F. Miao, and C. N. Lau. Superior thermal conductivity of single-layer graphene. Nano Lett. 8.3 (2008), pp. 902–907. doi: 10.1021/nl0731872 S. Chen, Q. Li, Q. Zhang, Y. Qu, H. Ji, R. S. Ruoff, and W. Cai. Thermal conductivity measurements of suspended graphene with and without wrinkles by micro-Raman mapping. Nanotech. 23.36, 365701 (2012). doi: 10.1088/0957-4484/23/36/365701 on p. C85). B. J. Cox, T. Dyer, and N. Thamwattana. A variational model for conformation of graphene wrinkles formed on a shrinking solid metal substrate. Mat. Res. Express 7.8, 085001 (2020). doi: 10.1088/2053-1591/abaa8f A. K. Geim. Graphene: Status and prospects. Science 324.5934 (2009), pp. 1530–1534. doi: 10.1126/science.1158877 on p. C85). K. Kostarelos and K. S. Novoselov. Graphene devices for life. Nature Nanotech. 9 (2014), pp. 744–745. doi: 10.1038/nnano.2014.224 F. Long, P. Yasaei, R. Sanoj, W. Yao, P. Král, A. Salehi-Khojin, and R. Shahbazian-Yassar. Characteristic work function variations of graphene line defects. ACS Appl. Mat. Inter. 8.28 (2016), pp. 18360–18366. doi: 10.1021/acsami.6b04853 R. Muñoz and C. Gómez-Aleixandre. Review of CVD synthesis of graphene. Chem. Vapor Dep. 19.10–12 (2013), pp. 297–322. doi: 10.1002/cvde.201300051 L. Spanu, S. Sorella, and G. Galli. Nature and strength of interlayer binding in graphite. Phys. Rev. Lett. 103.19, 196401 (2009). doi: 10.1103/PhysRevLett.103.196401 T. Verhagen, B. Pacakova, M. Bousa, U. Hübner, M. Kalbac, J. Vejpravova, and O. Frank. Superlattice in collapsed graphene wrinkles. Sci. Rep. 9.1, 9972 (2019). doi: 10.1038/s41598-019-46372-9 C. Wang, Y. Liu, L. Li, and H. Tan. Anisotropic thermal conductivity of graphene wrinkles. Nanoscale 6.11 (2014), pp. 5703–5707. doi: 10.1039/C4NR00423J W. Wang, S. Yang, and A. Wang. Observation of the unexpected morphology of graphene wrinkle on copper substrate. Sci. Rep. 7.1 (2017), pp. 1–6. doi: 10.1038/s41598-017-08159-8 Y. Wang, R. Yang, Z. Shi, L. Zhang, D. Shi, E. Wang, and G. Zhang. Super-elastic graphene ripples for flexible strain sensors. ACS Nano 5.5 (2011), pp. 3645–3650. doi: 10.1021/nn103523t Y. Wei, B. Wang, J. Wu, R. Yang, and M. L. Dunn. Bending rigidity and Gaussian bending stiffness of single-layered graphene. Nano Lett. 13.1 (2013), pp. 26–30. doi: 10.1021/nl303168w Z. Xu and M. J. Buehler. Interface structure and mechanics between graphene and metal substrates: A first-principles study. J. Phys.: Cond. Mat. 22.48, 485301 (2010). doi: 10.1088/0953-8984/22/48/485301 Y. Zhang, N. Wei, J. Zhao, Y. Gong, and T. Rabczuk. Quasi-analytical solution for the stable system of the multi-layer folded graphene wrinkles. J. Appl. Phys. 114.6, 063511 (2013). doi: 10.1063/1.4817768 W. Zhu, T. Low, V. Perebeinos, A. A. Bol, Y. Zhu, H. Yan, J. Tersoff, and P. Avouris. Structure and electronic transport in graphene wrinkles. Nano Lett. 12.7 (2012), pp. 3431–3436. doi: 10.1021/nl300563h
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Pei, Jiang. "On Translations and Translators of I. A. Krylov’s Fables in China." Izvestiia Rossiiskoi akademii nauk. Seriia literatury i iazyka 81, no. 1 (2022): 90. http://dx.doi.org/10.31857/s160578800018926-4.
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The article gives a overview of translations of I.A. Krylov’s fables in China. The first of them appeared more than 120 years ago, but the real acquaintance of Chinese readers with his work took place in the 1950s because of the translations of Meng Hai and Wu Yan. From the late 1970s to the present, the number of translations and editions of Krylov’s fables has been constantly increasing. Now in China there are more than 300 separate editions of his selected fables and 33 complete collections. At various times, at least 64 translators worked on translations of Krylov’s fables into Chinese, and 15 of them translated all nine books of the collection of his fables (these are Wu Yan, He Shiying, Feng Jia, Gu Yu, Xin Weiai, Han Guiliang, He Maozheng, Pei Jiaqin, Qu Hong, Yue Yan, Shi Guoxiong, Ding Lu, Zhu Xiansheng, Qiu Jingjuan and Yang Jianfeng). Some translations are made in prose, but some in poetry. The article summarizes the history of translations of Krylov’s fables in China and provides information about the most important translations and translators.
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Xu, Jia, Xufen Yu, Tiphaine C. Martin, Ankita Bansal, Kakit Cheung, Abigail Lubin, Elias Stratikopoulos, et al. "Abstract LB195: AKT degradation selectively inhibits the growth of PI3K/PTEN pathway mutant cancers with wild type KRAS and BRAF by destabilizing Aurora kinase B." Cancer Research 82, no. 12_Supplement (June 15, 2022): LB195. http://dx.doi.org/10.1158/1538-7445.am2022-lb195.
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Abstract PI3K/AKT/mTOR signaling pathway is one of the most frequently dysregulated pathway in cancer development and the serine/threonine kinase AKT functions as the key node in this pathway to regulate multiple cellular and physiological processes. AKT inhibitors that competitively bind the ATP pocket have been evaluated in clinical trials and have a tolerable toxicity profile with greater efficacy for tumors with pathway mutations; however, many PI3K/AKT pathway mutant tumors remain resistant. Proteolysis targeting chimeras (PROTACs) are a powerful targeted protein degradation technology that hijacks the cellular ubiquitin-proteasome system to induce selective polyubiquitination and degradation of the target proteins. Using this technology, we designed and developed a library of novel small-molecules putative degraders to degrade AKT by recruiting either the cereblon (CRBN) or von Hippel-Lindau (VHL) E3 ligase, that have the ability to degrade AKT in cells and lower downstream signaling to various extents. Though extensive structure-activity relationship studies on various linkers, E3 ligase ligands, and AKT binding moieties, we identified a novel VHL-recruiting AKT degrader, MS21, and characterized it using a panel of 38 cancer cell lines with diverse genotypes and tissue origins. Our results suggest that efficient pharmacologic degradation of AKT phosphorylated on threonine 308 and serine 473 leads to selective inhibition of the growth of tumor cells with alterations of HER2, PIK3CA, PTEN, or AKT1. In these PI3K/PTEN pathway mutant lines, AKT degradation by MS21 was superior to AKT kinase inhibition for reducing cell growth and sustaining lower signaling over many days, and inhibited tumor cell growths through lowering the level of Aurora Kinase B, which we found to be an AKT substrate protein. AKT degradation but not kinase inhibition profoundly lowered Aurora kinase B (AURKB) protein, which is known to be essential for cell division, and induced G2/M arrest and hyperploidy. PI3K activated AKT phosphorylation of AURKB on threonine 73, which protected it from proteasome degradation. A mutant of AURKB (T73E) that mimics phosphorylation and blocks its degradation rescued cells from growth inhibition by MS21. In addition, resistance to MS21 was found to be associated with low levels of baseline AKT phosphorylation in cells as well as mutation of either KRAS or BRAF, and resistance to MS21 could be overcome by the combination treatment of a MEK inhibitor trametinib with MS21, which not only inhibited MEK but also increased AKT phosphorylation and enhanced AKT degradation. Pan-cancer analysis identified that 19% of cases have PI3K/PTEN pathway mutation without RAS pathway mutation, suggesting that these cancer patients could benefit from AKT degrader therapy that leads to loss of AURKB. Citation Format: Jia Xu, Xufen Yu, Tiphaine C. Martin, Ankita Bansal, Kakit Cheung, Abigail Lubin, Elias Stratikopoulos, Kaitlyn M. Cahuzac, Li Wang, Ling Xie, Royce Zhou, Yudao Shen, Xuewei Wu, Shen Yao, Ruifang Qiao, Poulikos I. Poulikakos, Xian Chen, Jing Liu, Jian Jin, Ramon Parsons. AKT degradation selectively inhibits the growth of PI3K/PTEN pathway mutant cancers with wild type KRAS and BRAF by destabilizing Aurora kinase B [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB195.
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HUO, QING-BO, ABDUR REHMAN, YU-ZHOU DU, and ZHEN-NING CHEN. "Rediscovery of Perlodinella microlobata Wu, 1938, with notes on Tibetisoperla sclerotica Yan, Chen, Bozdogan & Li, 2022 (Plecoptera: Perlodidae)." Zootaxa 5205, no. 1 (November 4, 2022): 26–34. http://dx.doi.org/10.11646/zootaxa.5205.1.2.
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Perlodinella microlobata Wu, 1938 is rediscovered in Qinghai and Sichuan provinces with a supplementary description in this paper. Another species collected from Qinghai at the same time, Tibetisoperla sclerotica Yan, Chen, Bozdogan & Li, 2022, is partially revised because the adult female belongs to the chloroperlid genus Sweltsa Ricker, 1943.
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Živković, V., B. Stamenković, and S. Stojanović. "AB0455 HEMATOLOGICAL PARAMETERS AS THE MARKERS OF DISEASE ACTIVITY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1526.1–1526. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2501.
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Background:As the standard markers of systemic inflammation in autoimmune diseases erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are usually used, but in recent years there have been conflicting results about the potential significance of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR).Objectives:Our aim was to investigate the correlation of NLR and PLR with disease activity in patients with systemic lupus erythematosus (SLE).Methods:The study involved 160 patients with SLE (145 women and 15 men), hospitalized in the Clinic of Rheumatology, Institute „Niška Banja“, aged on the average 46.34 ± 10.82 years and with average disease duration of 9.76 ± 8.27 years, in whom the diagnosis was established based on the revised ACR criteria from 1997. In addition to clinical examination and supplementary tests, their disease activity was assessed using theSystemic Lupus Erythematosus Disease Activity Index(SLEDAI), together with determination of NLR and PLR.Results:In SLE patients, there was a positive correlation of NLR with ESR (r=0.212; p=0.010), anti-dsDNA antibodies (r=0.185; p=0.025), and PLR (r=0.601; p<0.001), as well as a negative correlation with complement component 3 (C3) (r=-0.264; p=0.003). Further, there was a positive correlation of PLR with ESR (r=0.329; p<0.001), CRP (r=0.249; p=0.003), anti-dsDNA antibodies (r=0.280; p=0.001), anti-nucleosome antibodies (r=0.263; p=0.026), and values of urinary chemoattractant protein-1 (MCP1) (r=0.263; p=0.043), as well as a negative correlation with C3 (r=-0.276; p=0.002). Our univariate analysis demonstrated that not only the values of ESR, CRP, C3, anti-dsDNA, anti-nucleosome, anti-C1q antibodies, serum and urinary MCP1 (p<0.001) were statistically significantly associated with SLEDAI, but also the NLR (p<0.001) and PLR (p<0.001). Using the method of standard multiple regression analysis, we examined the impact of the above parameters on SLEDAI. The examined model accounted for 21.7% of variance in activity index (corrected r2=0.217, F=2.525, p=0.017). As the statistically significant risk factors, ESR (Beta=0.394, p=0.020) and serum MCP1 (Beta=0.325, p=0.043) stood out.Conclusion:NLR and PLR, as hematological parameters available in everyday clinical work, can be significant for disease activity assessment in SLE patients.References:[1]Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD. The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases. Ann Lab Med. 2019;39(4):345-57.[2]Yu H, Jiang L, Yao L, Gan C, Han X, Liu R, Su N. Predictive value of the neutrophil-to-lymphocyte ratio and hemoglobin in systemic lupus erythematosus. Exp Ther Med. 2018;16(2):1547-53.[3]Wu Y, Chen Y, Yang X, Chen L, Yang Y. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with disease activity in patients with systemic lupus erythematosus. Int Immunopharmacol. 2016;36:94-9.[4]Yolbas S, Yildirim A, Gozel N, Uz B, Koca SS. Hematological Indices May Be Useful in the Diagnosis of Systemic Lupus Erythematosus and in Determining Disease Activity in Behcet’s Disease. Med Princ Pract. 2016;25(6):510–6.[5]Qin B, Ma N, Tang Q, Wei T, Yang M, Fu H, Hu Z, Liang Y, Yang Z, Zhong R. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol. 2016;26(3):372–6.Disclosure of Interests:None declared
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Haradhvala, Nicholas J., Mark B. Leick, Katie Maurer, Satyen Gohil, Rebecca C. Larson, Estelle Yao, Matthew J. Frigault, et al. "Abstract 3575: Differential dynamics of response at single cell resolution between axi-cel and tisa-cel CAR-T therapy in refractory B-cell lymphomas." Cancer Research 82, no. 12_Supplement (June 15, 2022): 3575. http://dx.doi.org/10.1158/1538-7445.am2022-3575.
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Abstract Chimeric Antigen Receptor (CAR)-T cell therapy has revolutionized the treatment of hematologic malignancies. Approximately half of patients with refractory large B-cell lymphomas achieve durable responses from CD19-targeting CAR-T treatment, across the commercially available CAR-T products with differing designs. Known failure mechanisms such as antigen loss account for only a fraction of cases without durable responses, and this knowledge gap has limited advances in CAR-T engineering and optimal targeting to patients. We hypothesized that characterization of the transcriptional programs and temporal evolution of CAR-T and host immune cell populations could provide novel insights into the basis of clinical response to CAR-T cell therapy for B cell lymphoma. We performed 10X single-cell RNA sequencing on serial samples collected from 32 individuals with high grade B cell lymphoma treated with the two first FDA-approved CD19 CAR-T products: axicabtagene ciloleucel (axi-cel, utilizing a CD28z costimulatory domain) and tisagenlecleucel (tisa-cel, with a 4-1BB domain). We analyzed 106 samples, including pre-infusion blood samples, infusion product, and post-infusion T cells sorted by flow cytometry into CAR+ and CAR- populations. Analyzing 602,577 single-cell transcriptomes, we discerned major differences in the dynamics of response of the two products. Tisa-cel responders showed dramatic expansion of CD8+ T cells at day 7 after infusion, which represented less than 10% of cells in the product. Conversely, CD8+ T cells in products of non-responders failed to expand to the same degree post-infusion and had a more effector- than memory-like T cell phenotype. In one tisa-cel–treated patient who had no CD8+ T cell expansion after initial infusion and relapsed at 6 months post-infusion, re-treatment with a second dose of the same product led to a durable response and was associated with greater CD8+ T cell expansion as well as a shift in CD4+ T phenotype from cytotoxic to helper. In contrast, axi-cel responders had pre-expanded effector populations distributed more heterogeneously among CD4+ and CD8+ T cells. Finally, we identified nominal elevations in CAR-T regulatory cells (CAR-Tregs) among both axi-cel and tisa-cel non-responders in our dataset, which we confirmed in an external dataset. These small increases in CAR-Tregs were sufficient to uniformly suppress conventional CAR-T cell expansion and drive late relapses in an in vivo mouse model of lymphoma after treatment with CARs with either CD28z or 4-1BB co-stimulatory domains. In summary, this represents the largest CAR-T scRNAseq cohort established thus far and provides important insights into (i) the temporal dynamics of a successful CAR-T response, (ii) the molecular phenotypes of CAR-T cells with different costimulatory domains, and (iii) the capacity for small increases in CAR-Tregs to drive relapse. Citation Format: Nicholas J. Haradhvala, Mark B. Leick, Katie Maurer, Satyen Gohil, Rebecca C. Larson, Estelle Yao, Matthew J. Frigault, Shuqiang Li, Kenneth J. Livak, Kahn Rhrissorrakrai, Filippo Utro, Chaya Levovitz, Raquel A. Jacobs, Kara Slowik, Brian P. Danysh, Laxmi Parida, Catherine J. Wu, Gad Getz, Marcela V. Maus. Differential dynamics of response at single cell resolution between axi-cel and tisa-cel CAR-T therapy in refractory B-cell lymphomas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3575.
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Cheng, Qianyu, Hongyu Peng, Shanshan Hu, Yafei Liu, Zeyu Chen, Balaji Raghothamachar, and Michael Dudley. "Effective Penetration Depths Investigation on Synchrotron X-Ray Topographic Images of Basal Plane Dislocations in 4H-SiC Crystals through Ray-Tracing Simulation." ECS Meeting Abstracts MA2022-02, no. 37 (October 9, 2022): 1355. http://dx.doi.org/10.1149/ma2022-02371355mtgabs.
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The demand for power electronic devices fabricated from silicon carbide (SiC) has increased rapidly in recent years for a diverse range of existing and emerging applications. The development of device technology highly depends on the quality of substrate and epitaxial material and the number of deleterious defects within, as those are critical factors that impact the device performance and long-term reliability [1, 2]. Therefore, understanding the nature of defects is of great importance for preventing the degradation or premature breakdown of devices. Synchrotron X-ray topography (XRT) is a dominant analytical method for the imaging and characterization of crystallographic defects. For 4° off-axis (0001) 4H-SiC wafers, the grazing-incidence geometry topographic technique is commonly employed to focus on the defect investigation near surface region. In this geometry, a small incidence angles (~1-2°) is used for allowing X-ray to only penetrate the sample with a shallow depth below the surface, therefore, it is essential to establish a procedure to define the effective penetration depth for detailed analysis of dislocation structures and density calculations. In earlier studies, Dudley in 1989 concluded that the observed penetration depths are limited by photoelectric absorption rather than extinction [3]. Ishiji in 2017 estimated the penetration depth based on the photoelectric absorption experienced by the diffracted X-rays [4]. However, only basal plane dislocations (BPDs) with screw segments parallel to the off-cut [11-20]-direction were evaluated in that study, which is insufficient for evaluating other types of BPDs. Therefore, a universal method to determine the effective penetration depth for all dislocation types would be of more practical importance. In this study, a procedure to define this effective penetration depth is demonstrated by investigating physical vapor transport (PVT) grown 4° off-axis 4H-SiC crystals through preforming systematic analysis of topographic and ray-tracing simulated contrast of BPDs with different Burgers vector and line direction combinations. The topographic images are recorded through synchrotron monochromatic beam in grazing incidence geometry. The simulation model is based on the principle of orientation contrast mechanism [5, 6] and developed by considering both the effects of surface relaxation [7] and X-ray absorption [8, 9] for evaluating the contributed factors of dislocation contrast formation. Analysis of the results indicates the observable dislocation contrast depends on the effective misorientation associated with the dislocation modulated by the photoelectric absorption effect. The dislocations with larger effective misorientation are associated with longer projected lengths and corresponding deeper effective penetration depths. A more simplified factor based on an approximate expression for the misorientation is also introduced in this study as an alternative to the full ray-tracing simulation approach. The effective penetration depth determination method presented in this study enables three-dimensional dislocation configuration analysis and accurate density calculations. Reference: Das, H., et al., Materials Science Forum, 2019. 963: p. 284-287. Kimoto, T., et al. 2017 IEEE International Reliability Physics Symposium (IRPS). 2017. Dudley, M., J. Wu, and G.D. Yao, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1989. 40-41: p. 388-392. Ishiji, K., et al., Japanese Journal of Applied Physics, 2017. 56(10): p. 106601. Dudley, M., X.R. Huang, and W. Huang, Journal of Physics D: Applied Physics, 1999. 32(10A): p. A139-A144. Huang, X.R., et al., Journal of Applied Crystallography, 1999. 32(3): p. 516-524. Peng, H., et al., Journal of Applied Crystallography, 2021. 54(2): p. 439-443. Fujie, F., et al., Acta Materialia, 2021. 208: p. 116746. Ailihumaer, T., et al., Materials Science and Engineering: B, 2021. 271: p. 115281. Figure 1
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Poškaitė, Loreta. "Book Review." Acta Orientalia Vilnensia 12, no. 2 (January 1, 2011): 125–31. http://dx.doi.org/10.15388/aov.2011.1.3928.
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Vilnius University, Centre of Oriental Studies Arthur Kleinman, Yunxiang Yan, Jing Jun, Sing Lee, Everett Zhang, Pan Tianshu, Wu Fei, Guo Jinhua.Deep China. The Moral Life of the Person, What Anthropology and Psychiatry Tell Us about China Today, Berkeley, Los Angeles, London: University of California Press, 2011, pp. 322. ISBN 978-0-520-26945-3 (paperback), $29.95, £19.95
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Ma, Z., J. Zhong, J. Xu, and Y. Wei. "Genotyping of the polymorphism within exon 1 of <i>Hormone Sensitive Lipase (LIPE)</i> Gene in three Chinese Yak (<i>Bos grunniens</i>) breeds by PCR-RFLP (Brief Report)." Archives Animal Breeding 52, no. 2 (October 10, 2009): 215–18. http://dx.doi.org/10.5194/aab-52-215-2009.
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Abstract. The yak (Bos grunniens), a herbivore living on the Qinghai-Tibetan Plateau and its adjacent territories, is one of world’s most remarkable domestic animals. Over the past decades, research has been done on properties of yak meat at physiological and biochemical levels. In recent years, some candidate genes associating with meat quality and lipid metabolism in yak have been studied (MA et al. 2007, ZHONG et al. 2007). The Hormone Sensitive Lipase (LIPE) gene has been regarded as a candidate gene associating with lipid metabolism and meat quality. Several studies have reported the genetic variations in the LIPE genes of human and pig (TALMUD et al. 1998, KNOLL et al. 1998, WU et al. 1998, HARBITZ et al. 1999), whereas the yak LIPE gene polymorphism has not been investigated and no information is available. The aim of this study was to identify and characterize the genetic variation in Chinese yak LIPE at the DNA sequence level and genotyping of the polymorphism within LIPE in different yak breeds.
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Yan, Yu-Chen, Wen-Long Yan, Tie-Jun Deng, and Mei-Cai Wei. "Asicimbex Yan, Deng & Wei, a new genus with eight new species and four new combinations (Hymenoptera, Cimbicidae)." Journal of Hymenoptera Research 91 (June 30, 2022): 265–308. http://dx.doi.org/10.3897/jhr.91.83710.
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A new genus and eight new species of Cimbicinae from the East Asia are described: Asicimbex Yan, Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov., A. koreanus Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov., A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new combinations are proposed: A. eous (Semenov, 1935) comb. nov., A. elminus (Li & Wu, 2003) comb. nov., A. ulmusvorus (Yang, 1996) comb. nov. and A. malaisei (Gussakovskij, 1947) comb. nov., all from Agenocimbex. The 12 known species of Asicimbex are separated into two species groups. Asicimbex stands between Agenocimbex Rohwer 1910 and Cimbex Olivier 1791. The differences between Asicimbex and Cimbex, Asicimbex and Palaeocimbex are discussed in detail. Descriptions, remarks, illustrations, a key to the known species of Asicimbex and a key to genera of Cimbicinae are provided. A. malaisei is confirmed as a valid species and recorded from China for the first time, with the female described for the first time. The distribution of the genus is also briefly discussed.
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Hartmann, Louis, Cheuck Hin Ching, Tim Kipfer, and Hubert Andreas Gasteiger. "Aqueous-Based Post-Treatment of Li- and Mn-Rich Ncm." ECS Meeting Abstracts MA2022-01, no. 2 (July 7, 2022): 415. http://dx.doi.org/10.1149/ma2022-012415mtgabs.
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To achieve lithium-ion batteries with high energy density at competitive prices for automotive and large-scale applications, cathode active materials (CAMs) based on Li- and Mn-rich NCMs (LMR-NCMs), like Li1.14(Ni0.26Co0.14Mn0.60)0.86O2, are promising candidates.[1] However, LMR-NCMs still suffer from high gassing, particularly during cell formation, and detrimental voltage and capacity fading over their cycle life.[2,3] Different approaches can be utilized to try to mitigate these issues, such as the use of electrolyte additives, novel material designs (compositional gradients, etc.), or post-treatments.[4–7] In this study, we investigated the effect of a water-based post-treatment of LMR-NCM. It consists of a washing process of the LMR-NCM that results in a partial delithiation of its near-suface region by a lithium/proton ion exchange, while at the same time avoiding transition metal dissolution. A recalcination of this protonated near-surface layer of the LMR-NCM particles results in the formation of a protective spinel-like surface layer. We observed that after this treatment, the gassing during formation is decreased by »10-fold. Furthermore, the cycling performance of graphite/LMR-NCM full-cells is also drastically increased. By conducting on-line electrochemical mass spectrometry (OEMS) measurements, we analyzed the gas evolution of as-received and post-treated LMR-NCMs during the first activation cycle. It is known from the literature that the activation of LMR-NCMs is accompanied by a strong O2 and CO2 evolution during the first charge.[2] As seen in Figure 1, CO2 is evolved simultaneously with O2 from Li/LMR-NCM half-cells, prepared with untreated, as-received LMR-NCM (as-received, black line). With post-treated LMR-NCM, both CO2 and O2-evolution during the activation cycle are reduced by »10-fold (post-treated, green line). Only a small amount of the first-charge capacity (<10%) is lost due to the post-treatment, as seen in Figure 1a, reflecting the slight extent of delithiation that is part of the post-treatment. As will be shown, cycling tests of graphite/LMR-NCM full-cells with a post-treated LMR-NCM reveal a greatly increased cycling stability in comparison to cells with an as-received material. Using TGA-MS, XPS and ICP-OES, we further elucidate the beneficial mechanism of the here developed water-based post-treatment. References: [1] D. Andre, S.-J. Kim, P. Lamp, S. F. Lux, F. Maglia, O. Paschos, B. Stiaszny, J. Mater. Chem. A 2015, 3, 6709–6732. [2] T. Teufl, B. Strehle, P. Müller, H. A. Gasteiger, M. A. Mendez, J. Electrochem. Soc. 2018, 165, A2718–A2731. [3] B. Strehle, K. Kleiner, R. Jung, F. Chesneau, M. Mendez, A. Hubert, J. Electrochem. Soc. 2017, 164, 400–406. [4] Z. Zhu, D. Yu, Y. Yang, C. Su, Y. Huang, Y. Dong, I. Waluyo, B. Wang, A. Hunt, X. Yao, J. Lee, W. Xue, J. Li, Nat. Energy 2019, 4, 1049–1058. [5] S. Ramakrishnan, B. Park, J. Wu, W. Yang, B. D. Mccloskey, J. Am. Chem. Soc. 2020, 142, 8522–8531. [6] A. Gue, C. Bolli, M. A. Mendez, E. J. Berg, ACS Appl. Energy Mater. 2020, 3, 290–299. [7] J. Sicklinger, H. Beyer, L. Hartmann, F. Riewald, C. Sedlmeier, H. A. Gasteiger, J. Electrochem. Soc. 2020, 167, 130507. Acknowledgements This work is financially supported by the BASF SE Network on Electrochemistry and Battery Research. Figure 1: OEMS measurements of the first lithiation half-cycle to 4.8 V of Li/LMR-NCM half-cells with either an as-received (black line) or a post-treated LMR-NCM (green line). a) Cell voltage vs. time at a C/rate of C/10 (referenced to 250 mAh/g delithiation capacity). b) CO2 evolution given in units of μmol/gCAM (determined from the signal at m/z = 44). c) O2 evolution (from m/z = 32). The half-cells were charged at 25°C, using an FEC/DEC (2:8) electrolyte with 1.0 m LiPF6. Figure 1
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Tian, Nai-Feng, and Fang-Min Mao. "Answer to the Letter to the Editor of Feng Li et al. entitled “Minimally invasive versus open transforaminal lumbar interbody fusion: a meta-analysis based on the current evidence” by Nai-Feng Tian, Yao-Sen Wu, Xiao-Lei Zhang, Hua-Zi Xu, Yong-Long Chi, Fang-Min Mao (2013). Eur Spine J, doi:10.1007/s00586-013-2747-z." European Spine Journal 23, no. 4 (January 18, 2014): 929–30. http://dx.doi.org/10.1007/s00586-014-3185-2.
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Waring, Luke. "INTRODUCING THE *WU ZE YOU XING TU MANUSCRIPT FROM MAWANGDUI." Early China 43 (July 27, 2020): 123–60. http://dx.doi.org/10.1017/eac.2020.3.
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AbstractThe *Wu ze you xing tu 物則有形圖 silk manuscript was discovered inside a lacquer case in Mawangdui Tomb 3. This little-known manuscript of unusual design contains a philosophical text on the relationships between things (wu 物), forms (xing 形), names (ming 名), and speech (yan 言), and the text is arranged on the surface of the silk in the form of a densely clustered spiral within a ring inside a square. The writing on the manuscript is also accompanied by colors and shapes that represent a domed Heaven (tian 天) above a square Earth (di 地). Since it was first catalogued in 2004, just a few studies of the *Wu ze you xing tu have been published in Chinese, and the manuscript is almost entirely absent from Western scholarship. This article aims to remedy this situation by providing a detailed description of the manuscript, transcriptions and translations of its contents, a consideration of its philosophical context, and an analysis of its design. In the process, I show that this silk document functioned not just as a convenient surface or carrier for an important philosophical text, but as a material artifact in its own right, one that was designed to have a powerful impact on its viewers, readers, and users, forcing them to move their eyes and bodies in ways that reinforced its central philosophical message.
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Bian, Dongfen, Jingjing Mao, and Xueke Pu. "Stability of hydrostatic equilibrium for the 2D BMHD system with partial dissipation." Communications on Pure and Applied Analysis 21, no. 10 (2022): 3441. http://dx.doi.org/10.3934/cpaa.2022109.
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<p style='text-indent:20px;'>In this paper, we establish the nonlinear stability and large time behavior of hydrostatic equilibrium in a uniform magnetic field for the Boussinesq system with magnetohydrodynamics convection in the whole space <inline-formula><tex-math id="M1">\begin{document}$ \mathbb{R}^{2} $\end{document}</tex-math></inline-formula> with mixed partial dissipation, motivated by Lai, Wu, Zhong [<xref ref-type="bibr" rid="b18">18</xref>] and Lin, Ji, Wu and Yan [<xref ref-type="bibr" rid="b22">22</xref>]. Due to the lack of horizontal dissipation and vertical dissipation in the second component of velocity, the natural energy is not easy to be closed, which is overcome by introducing an additional functional of the horizontal derivative of the second component of velocity. This shows that the magnetic field and the temperature have a stabilizing effect on the fluid. Large time behavior and linear decay rate of the solution are also obtained.</p>