Academic literature on the topic 'Yekaterina II'

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Journal articles on the topic "Yekaterina II"

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Cook, Andrew, Rebecca Stephens, Nadezda Fursova, Carson C. Chow, Dan Larson, and Yekaterina Miroshnikova. "Abstract 5641: Transcriptional regulation by nuclear deformation." Cancer Research 84, no. 6_Supplement (2024): 5641. http://dx.doi.org/10.1158/1538-7445.am2024-5641.

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Abstract Establishment and maintenance of cell identities requires transcriptional rewiring and modulation of three-dimensional genome organization. The nucleus is subject to constant mechanical forces, both intrinsic from the cytoskeleton and extrinsic, such as compression, confinement, and stretch. Recently, work from us and others implicate mechanical force, through activating biochemical signaling pathways as well as direct nuclear deformation, in remodeling nuclear architecture, chromatin state and global gene expression patterns. Thus, we hypothesize that mechanical force plays an import
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Johnson, Jeremy, Yekaterina Y. Zaytseva, Jennifer Castle, B. Mark Evers, and Piotr Rychahou. "Abstract 2308: Inhibition of fatty acid synthesis and concurrent lipid deprivation decreases neuroendocrine cancer cell proliferation and colony formation." Cancer Research 82, no. 12_Supplement (2022): 2308. http://dx.doi.org/10.1158/1538-7445.am2022-2308.

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Abstract Introduction. Gastroenteropancreatic neuroendocrine tumors (GEP-NETs), the second most common digestive cancer in terms of prevalence, can be particularly challenging to treat due to resistance to current clinical regimens. Lipid metabolism provides an important energy source for cancer cells; cells increase lipid supply by endogenous synthesis or exogenous uptake. Both processes can become dysregulated in cancer, but little is known about the role of either pathway in neuroendocrine tumors (NETs). The goal of this project was to determine whether inhibition of lipid synthesis with co
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Tessmann, Josiane Weber, Jerika Durham, Ryan Goettl, et al. "Abstract 1480: Perfluorooctanesulfonic acid exposure promotes pathological changes in normal intestinal tissues which may lead to an increased risk of colorectal cancer development." Cancer Research 84, no. 6_Supplement (2024): 1480. http://dx.doi.org/10.1158/1538-7445.am2024-1480.

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Abstract Introduction: Long-term exposures to per- and polyfluoroalkyl substances (PFAS) have been increasingly linked to negative health outcomes including metabolic disorders, reduced immune responses, and increased risk of cancer. PFOS, one the most frequently detected PFAS in drinking water, is readily absorbed in the GI tract and distributes predominantly to the plasma and liver. Even though recent studies demonstrate that PFOS can cause an imbalance of cecal gut microbiota, alter microbiota diversity, and promote inflammation and gut barrier dysfunction, there is still not much known abo
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Kelson, Courtney Olivia, James Drury, Daheng He, Chi Wang, and Yekaterina Zaytseva. "Abstract 2581: Fatty acid synthase regulates expression of Notum in colorectal cancer." Cancer Research 83, no. 7_Supplement (2023): 2581. http://dx.doi.org/10.1158/1538-7445.am2023-2581.

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Abstract Background: Upregulation of lipid synthesis has been associated with poor clinical outcomes in colorectal cancer (CRC). Fatty acid synthase (FASN) synthesizes 16-carbon fatty acid palmitate which can be utilized for post-translational modifications of various proteins. Notum, a palmitoleoyl-protein carboxylesterase, is involved in the negative regulation of the Wnt signaling via its role in de-palmitoylation of Wnt ligands and has been identified as a marker for poor prognosis in CRC. However, the crosstalk between FASN and Notum has not been reported. Our preliminary data suggest tha
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Larionov, Oleg. "Russian Literature of the Epoch of Catherine II Between Imperial and Civil Society (Review of Joachim Klein’s book Pri Yekaterine. Trudy po russkoy literature 18 veka, Izdatel’skiy dom YaSK, 2021)." Novoe literaturnoe obozrenie, no. 5 (2022): 342–45. http://dx.doi.org/10.53953/08696365_2022_177_5_342.

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Nasimova, Umida Hamdam qizi. "XVIII ASR IKKINCHI YARMI XIX ASRDA ROSSIYANING KAVKAZ HUDUDIDA AMALGA OSHIRGAN HARBIY HARAKATLARI." April 20, 2022. https://doi.org/10.5281/zenodo.7238827.

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Ushbu maqolada Rossiyaning imperiyaga aylanishi natijasida uning sarhadlari kengayib borishi bu orada uning muhim strategik ahamiyatga ega bo‘lgan Kavkazni egallashga intilishi kuchayib borishi aks ettirilgan. Rossiyani egallashga qaratilgan harbiy harakatlar Pyotr I davrida boshlanadi va bu harbiy harakatlarni Yekaterina I va Yekaterina II,Pavel I davrida bir qadar jiddiy tus olishi bayon etilgan. Ayni Kavkaz masalasida Umonli imperiyasi,Eron va Rossiya manfaatlarining to‘qnash kelishi bu holatda Rossiyaning mintaqani egallashda o‘ziga xos yondashuvi bayon etilgan.Yekaterina
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AKBABA, Yusuf. "THE FORGOTTEN PIONEER OF SIBERIAN STUDIES: GERHARD FRIEDRICH MÜLLER ABSTRACT." Genel Türk Tarihi Araştırmaları Dergisi, July 13, 2022. http://dx.doi.org/10.53718/gttad.1120541.

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Müller, a scientist of German origin, was born into a bourgeois, educator family. The joint studies of German-Russian scientists during the reign of Peter the Great, especially the fact that German scientists went to Russia, also influenced Müller. After Müller went to Russia as a graduate historian, he carried out almost all of his scientific studies there. He took important positions at the Petersburg Academy of Sciences, which he entered shortly after and served for many years. Also, the expeditions that started during the reign of Peter the Great enabled Müller to discover his main field o
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