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Journal articles on the topic 'Yi xue'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 July 2024

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1

Wang, Xiangsheng, Jing Huang, Shengyi Wang, and Qing Ni. "The Chinese Herb Yi-Qi-Huo-Xue Protects Cardiomyocyte Function in Diabetic Cardiomyopathy." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/7316840.

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Aims. To study the effect of the Chinese herb Yi-qi-huo-xue on cardiomyopathy in diabetic rats. Methods. Rats were fed a high fat and high glucose diet and injected with 50 ml/kg streptozotocin (STZ) to induce diabetic cardiomyopathy (DCM), followed by treatment with Yi-qi-huo-xue for 4 weeks. We measured the rats’ heart weight index, observed the myocardial morphology using hematoxylin eosin (HE) staining, and determined the content of collagen types I and III in the myocardium using enzyme-linked immunosorbent assay (ELISA). We determined Bcl-2, Bax, and P53 protein expression by Western blot analysis and the cardiomyocyte apoptosis rate via a flow cytometry assay. Results. Compared with the rats in the control group, the diabetic rats gained weight and had increased blood sugar levels, an enhanced heart weight index, and increased myocardial pathophysiological damage. There was a decrease in their Bcl-2 expression, and their Bax and P53 expression increased. The Bcl-2/Bax ratio was enhanced, and there was an increase in the content of collagen types I and III in the myocardium. After treatment with Yi-qi-huo-xue, all levels listed above returned to normal. Conclusion. The Chinese herb Yi-qi-huo-xue degraded the myocardial interstitial collagen types I and III to protect the myocardium of the diabetic rats, thus delaying the role of myocardial fibrosis. Yi-qi-huo-xue could play an important role in protecting the myocardium of DCM rats by enhancing the expression of the Bcl-2 protein, inhibiting the expression of the Bax and P53 proteins, increasing the ratio of Bcl-2/Bax, and inhibiting the apoptosis of cardiomyocytes.

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2

Geunsik Seo. "Xinghuxuepai process of the formation of the Dasan Jeong Yak-Yong' Yi Xue(易學)(Ⅲ) - From Li Yi, Shen Hou Dan' Yi Xue to Jeong Yak-Yong Yi Xue." JOURNAL OF KOREAN PHILOSOPHICAL HISTORY ll, no. 53 (May 2017): 35–61. http://dx.doi.org/10.35504/kph.2017..53.002.

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3

이선경. "Toegye School’s Interpretation of Yi Xue Qi Meng." YANG-MING STUDIES ll, no. 28 (April 2011): 261–300. http://dx.doi.org/10.17088/tksyms.2011..28.010.

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Geunsik Seo. "A Study of YulGok Yi Yi's communicational I-Xue." JOURNAL OF KOREAN PHILOSOPHICAL HISTORY ll, no. 25 (March 2009): 197–222. http://dx.doi.org/10.35504/kph.2009..25.007.

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5

Төрбат, Цагаан. "Ашина овгийн хатны эртний геном нь Хөх түрэгийн хаант улсыг Зүүн хойд Азийн гаралтай болохыг харуулжээ." Mongolian Journal of Anthropology, Archaeology and Ethnology 13, no. 1 (May 10, 2024): 141–45. http://dx.doi.org/10.22353/mjaae.20241301013.

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Xiao‐Min Yang, Hai‐Liang Meng, Jian‐Lin Zhang, Yao Yu, Edward Allen, Zi‐Yang Xia, Kong‐Yang Zhu, Pan‐Xin Du, Xiao‐Ying Ren, Jian‐Xue Xiong, Xiao‐Yu Lu, Yi Ding, Sheng Han, Wei‐Peng Liu, Li Jin, Chuan‐Chao Wang, and Shao‐Qing Wen. Ancient genome of Empress Ashina reveals the Northeast Asian origin of Göktürk Khanate. – Journal of Systematic and Evolution. Institute of Botany, Chinese Academy of Sciences. 2023. Volume 00 (0) 1-9.

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Son, Jun-Sik. "Establishment and Characteristic of Taiwan Yi Xue(義學) in Ching Period." Journal of Ming-Qing Historical Studies 7 (October 31, 1997): 1–31. http://dx.doi.org/10.31329/jmhs.1997.10.7.1.

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7

HUANG, SI-YAO, XIN-YUE WANG, and XIAO-LING FAN. "A new species of the genus Sovia Evans, 1949 from South Central Yunnan, China (Lepidoptera, Hesperiidae)." Zootaxa 4731, no. 4 (February 10, 2020): 565–73. http://dx.doi.org/10.11646/zootaxa.4731.4.9.

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A new species of the genus Sovia Evans, 1949, viz. S. liuzihaoi Huang & Fan sp. nov. is described from Mt. Ailao, Xinping Yi and Dai Autonomous County, representing a remarkable geographically southward extension of this genus in Yunnan Province, Southwestern China. In general appearance S. liuzihaoi Huang & Fan sp. nov. resembles S. separata magna (Evans, 1932), but in our molecular phylogenetic analyses, this species is clustered with S. lii Xue, 2015. The adults and male genitalia of the new species and related species are illustrated.

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8

Xu, Lei. "A brief introduction of Yi Xue Shi (《医学史》 History of Medicine)." Chinese Medicine and Culture 2, no. 3 (2019): 145. http://dx.doi.org/10.4103/cmac.cmac_33_19.

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9

이선경. "Ki Ho School of Neo-Confucianism on Yi Xue Qi Meng in Later Chosun Period." JOURNAL OF KOREAN PHILOSOPHICAL HISTORY ll, no. 35 (November 2012): 275–308. http://dx.doi.org/10.35504/kph.2012..35.010.

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10

Kononchuk, D. V. "Should “The Book of Changes” be studied “apart from the “Spirits”? Towards the necessity of new interpretations of the Lun Yu." Orientalistica 3, no. 5 (December 29, 2020): 1344–57. http://dx.doi.org/10.31696/2618-7043-2020-3-5-1344-1357.

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In the article, the author justifies the necessity to work out the principles of the approach, which would underline the principles of the commented translation of the Lun Yu (The Analects) from Chinese into Russian. The prospective authors of this translations must take into consideration both the existent translations as well as the existing comments This approach would enable to select the relevant parts from the Lun Yu, which are difficult for understanding due to The Analects which are difficult to understand due to the use of polysemantic expressions and vocabulary. The article comprises a brief textual review of the earlier versions of Lun Yu and offers a new commented translation of the two well-known fragments of the text. They are fragment 6.22 (on self-sufficiency, guided by a sense of duty) and fragment 7.17 (“on adding years”). The author suggests a new understanding of the well-known expressions, such as yan zhi 遠之 (6.22) as “Keeping distance [from ghosts and spirits]”, and xue yi 學易 (7.17) as “Study the [book of] Changes”. Likely, in the first case, it suggests “not to depend depending on the ghosts and spirits because everyone should rely primarily on himself. In the second case, it implies the act of teaching as such. The author’s results are based upon the commentaries, viz. Lun yu ji jie yi shu and Lun yu ji zhu. The yan zhi 遠之 was interpreted as “do not disturb”. And the second one is based on the found in 1973 the earliest known commentary for Lun Yu, where “Changes” yi 易 is only a homophonic auxiliary expression with the attached word yi 亦. These examples show that even the well-known and thoroughly researched text can receive new interpretation by putting it into a new boarder textual context

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11

Huang, Yong. "Neo-Confucian Hermeneutics at Work:Cheng Yi's Philosophical Interpretation of Analects 8.9 and 17.3." Harvard Theological Review 101, no. 2 (April 2008): 169–201. http://dx.doi.org/10.1017/s0017816008001776.

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In this article, I discuss the Song 宋 Neo-Confucian Cheng Yi's 程頤 (1033–1107) interpretation of two related controversial passages in the Analects, the recorded sayings of Confucius. The term “neo-Confucianism” was coined by Western scholars to refer to the Confucianism of the period from the Song dynasty to the Ming 明 dynasty (and sometimes through the Qing 清 dynasty). Among Chinese scholars, neo-Confucianism is most commonly referred to as the Learning of Principle (li xue 理學). Although before Cheng Yi and his brother Cheng Hao 程顥 (1032–1085) there were three other philosophers who are normally also regarded as neo-Confucians— Shao Yong 邵雍 (1011–1077), Zhou Dunyi 周敦頤 (1017–1073), and Zhang Zai 張載 (1020–1077)—we can justifiably regard the Cheng brothers as the real founders of neo-Confucianism in the sense that principle becomes the essential philosophical concept for the first time in their works. There is no consensus among scholars as to the relationship between the philosophies of these two brothers. The traditional view regards them as substantially different due to the two different schools of neo-Confucianism that developed from their teachings, the realistic school synthesized by Zhu Xi 朱熹 (1130–1200) from the teachings of Cheng Yi and the idealist school culminating in Wang Yangming 王陽明 (1472–1529) from the teachings of ChengHao. I, however, tend to think that the philosophical positions of the two brothers are largely similar. Unfortunately, since Cheng Hao did not live as long as Cheng Yi, there is insufficient material to create a systematic picture of his view of the Analects passages with which this article will deal.

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Zhang, Ruilong. "Review of Luo Jianqiu’s Jiaqing yi lai Han xue chuan tong de yan bian yu chuan cheng." Jiuzhou Xuelin 2011, no. 28 (April 1, 2012): 189–202. http://dx.doi.org/10.5404/jiuzhou.2011.28.09.

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13

Xiao, Rui, and Huan Yu. "Yu Liao Ku Xi Ju Fan Yi Wen Ti Xue (‘Introducing Corpus Stylistics into Drama Translation Studies’)." Australian Journal of Linguistics 37, no. 1 (March 7, 2016): 99–102. http://dx.doi.org/10.1080/07268602.2016.1146056.

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14

LI, Fang-He, Xiao-Lou HUANG, Hui WANG, Shu-Wen GUO, and Ping LI. "Protective effect of Yi-Qi-Huo-Xue Decoction against ischemic heart disease by regulating cardiac lipid metabolism." Chinese Journal of Natural Medicines 18, no. 10 (October 2020): 779–92. http://dx.doi.org/10.1016/s1875-5364(20)60018-8.

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15

Lu, Mingyu, Tianxiang Zheng, and Keyu Wang. "Reinterpreting and Remapping Philosophy, Evolutionism and Religion in Late Qing Missionary’s Translation of The Making of a Man." Religions 14, no. 10 (October 6, 2023): 1268. http://dx.doi.org/10.3390/rel14101268.

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Between the Boxer Movement and the 1911 Revolution, missionaries in China confronted distinct social challenges compared to their counterparts in home countries. In response, American missionary Young John Allen and his Chinese assistant, Van Yi, co-translated James Wideman Lee’s The Making of a Man into Chinese as Ren Xue. This translation aimed to counter Spencer’s social evolutionism, introduced by native intellectuals like Yan Fu, offering a reinterpretation of the relationships among individuals, nations, and God. Additionally, it sought to remap philosophy, evolutionism, ethics, and religion tailored for late Qing China. In contrast to clergymen in America and China, Chinese native intellectuals developed their unique reinterpretations and reshaping of philosophy, science, evolutionism, ethics, and religion for China. Through a cross-comparison of works by Yan Fu, Huxley, Spencer, Lee and Allen, this study explored the diverse responses to Spencer’s evolutionary theory and related issues among the advocates of evolutionism, Chinese intellectuals, and clergies in America and China.

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이선경. "The Characteristics of Zhu Xi's Theory of I-Qing in Yi Xue Qi Meng(易學啓蒙)." JOURNAL OF KOREAN PHILOSOPHICAL HISTORY ll, no. 28 (March 2010): 387–415. http://dx.doi.org/10.35504/kph.2010..28.014.

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17

Eom, Yeon-seok. "The Problem of Reversible Change between Natural Science and Moral Philosophy in the Toegye's Yi-Xue 易學." Journal of T'oegye Studies 146 (December 30, 2019): 5–38. http://dx.doi.org/10.46264/toegye.2019.146.01.

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刘, 敏. "Professor Jin Zhichun’s Application of Bu Shen Yi Qi and He Xue in the Treatment of Immune Infertility Experience." Traditional Chinese Medicine 06, no. 04 (2017): 186–90. http://dx.doi.org/10.12677/tcm.2017.64030.

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Xiao, Rui. "Yi Zhong Qiu Tong: Zhong Guo Dang Dai Yi Xue Shu Yu De Dong Tai Xing Cheng [Seeking Understanding from Differences: The Dynamic Formation of Chinese Contemporary Translation Terminology]." Australian Journal of Linguistics 39, no. 2 (May 21, 2017): 271–75. http://dx.doi.org/10.1080/07268602.2017.1311293.

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20

Changil Lee. "The Philosophical Review on Kim Hae(金楷, 1633~1716)’s Yi Xue Qi Ment Fu Yi(易學啓蒙覆繹) : Focusing on the systems and its contents." 영남학 ll, no. 66 (September 2018): 7–38. http://dx.doi.org/10.36034/yncdoi.2018..66.7.

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21

Meng, Yan. "On the Narrative Strategy and Moral Value of The Main Theme Movie "Me and My Motherland"." International Journal of Education and Humanities 13, no. 3 (April 24, 2024): 216–20. http://dx.doi.org/10.54097/ww670c80.

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"My Motherland and I" is a film by Chen Kaige as the chief director, Huang Jiaxin as the chief producer, Zhang Yibai, Guan Hu, Xue Xiaolu, Xu Zheng, Ning Hao, Wen Muye co-directed, Huang Bo, Zhang Yi, Wu Jing, Du Jiang, Ge You, Liu Haoran, Chen Feiyu, Song Jia and other people co-starring in a drama film. The film depicts the experiences of seven ordinary people who are closely connected with major national events, and through the perspectives of small characters, shows the deep connection between ordinary people and the country in the 70 years since the founding of New China. Since the film itself was made to celebrate the 70th anniversary of the founding of New China, it is of great research value. This paper aims to study two questions: one is to study the professional narrative strategies used in the film; The second is to sum up the educational significance and moral value of the film. Therefore, this thesis starts from the narrative strategy and moral value of the film, analyzes the content of the film "My Country and I", and explores the far-reaching value expressed by the whole film.

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Jo, Hak-Jin. "The Classification and Criterion for Low Back Pain Examined from Reference Books of Yi Xue Ru Men(醫學入門)." Journal of Korean Medical classics 28, no. 1 (February 25, 2015): 35–53. http://dx.doi.org/10.14369/skmc.2015.28.1.035.

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Kim, Seon-hee. "Tao (道) and Xue (學), Yi (藝) and Shu (術) : Introduction of Western Learning and the Transformation of Confucianism in Joseon Dynasty." Korean Silhak Review 35 (June 30, 2018): 287–328. http://dx.doi.org/10.23945/kss.35.287.328.

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Zhang, Xun, Shilei Song, Miaodong Wang, Zhifeng Wei, and Xin Deng. "Treatment on Acute Liver Injury with Tian Jing Yi Xue Decoction by Repressing the PI3K/AKT/mTOR Signaling Pathway and Reducing Inflammation." Journal of Biobased Materials and Bioenergy 18, no. 2 (March 1, 2024): 225–39. http://dx.doi.org/10.1166/jbmb.2024.2358.

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The increasing incidence of drug-induced acute liver injury (ALI) has drawn global attention to this health concern. Tian Jing Yi Xue Decoction (TJYXD), an ancient formula, has shown potential clinical efficacy for ALI. However, no studies have yet confirmed its effectiveness in treating ALI. In this study, we investigate the therapeutic potential of TJYXD in H2O2-induced HepG2 cell injury and CCl4-induced liver injury in Sprague-Dawley rats. High-performance liquid chromatography-mass spectrometry was used to analyze TJYXD components. Network pharmacology was employed to predict its mechanisms and effective components for ALI treatment, followed by experimental verification. In cellular experiments, 2 mg/mL TJYXD significantly reduced the levels of alanine transaminase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). In animal experiments, TJYXD significantly decreased the levels of ALT, ALP, and malondialdehyde and increased the level of superoxide dismutase. Histopathological analysis with Hematoxylin and Eosin staining and Masson staining further confirmed the efficacy of TJYXD compared to silymarin in treating ALI. Moreover, we determined that the therapeutic effects of TJYXD in the treatment of ALI were attributed to its inhibition of the PI3K/AKT/mTOR pathway and reduction in both serum and livers levels of transforming growth factor-β 1, interleukin-6, tumor necrosis factor-α. Furthermore, quercetin, apigenin, and luteolin were speculated to be the main active constituents. In conclusion, TJYXD demonstrates remarkable efficacy both in vitro and in vivo for the treatment of ALI by enhancing immunity and suppressing inflammation. Furthermore, TJYXD holds promise as a first-line or adjunctive therapeutic agent.

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Lin, Yixuan, Chuqiao Shen, Fanjing Wang, Zhaohui Fang, and Guoming Shen. "Network Pharmacology and Molecular Docking Study on the Potential Mechanism of Yi-Qi-Huo-Xue-Tong-Luo Formula in Treating Diabetic Peripheral Neuropathy." Journal of Diabetes Research 2021 (May 28, 2021): 1–16. http://dx.doi.org/10.1155/2021/9941791.

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Objective. To investigate the potential mechanism of action of Yi-Qi-Huo-Xue-Tong-Luo formula (YQHXTLF) in the treatment of diabetic peripheral neuropathy (DPN). Methods. Network pharmacology and molecular docking techniques were used in this study. Firstly, the active ingredients and the corresponding targets of YQHXTLF were retrieved using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) platform; subsequently, the targets related to DPN were retrieved using GeneCards, Online Mendelian Inheritance in Man (OMIM), Pharmgkb, Therapeutic Target Database (TTD) and Drugbank databases; the common targets of YQHXTLF and DPN were obtained by Venn diagram; afterwards, the “YQHXTLF Pharmacodynamic Component-DPN Target” regulatory network was visualized using Cytoscape 3.6.1 software, and Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the potential targets using R 3.6.3 software. Finally, molecular docking of the main chemical components in the PPI network with the core targets was verified by Autodock Vina software. Results. A total of 86 active ingredients and 229 targets in YQHXTLF were screened, and 81 active ingredients and 110 targets were identified to be closely related to diabetic peripheral neuropathy disease. PPI network mapping identified TP53, MAPK1, JUN, and STAT3 as possible core targets. KEGG pathway analysis showed that these targets are mostly involved in AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, and MAPK signaling pathway. The molecular docking results showed that the main chemical components of YQHXTLF have a stable binding activity to the core pivotal targets. Conclusion. YQHXTLF may act on TP53, MAPK1, JUN, and STAT3 to regulate inflammatory response, apoptosis, or proliferation as a molecular mechanism for the treatment of diabetic peripheral neuropathy, reflecting its multitarget and multipathway action, and providing new ideas to further uncover its pharmacological basis and mechanism of action.

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Perricone, C., G. Cafaro, R. Ilenia, S. Calvacchi, E. Marcucci, S. Cipriani, O. Bistoni, R. Gerli, and E. Bartoloni Bocci. "AB0743 Biomarkers in systemic sclerosis: a 23-plex cytokine/chemokine analysis." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1497.1–1497. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5061.

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BackgroundSystemic Sclerosis (SSc) is a rare inflammatory disease of unknown etiology associated with multi-organ involvement. Biomarkers remain urgently needed as tools for differential diagnosis, prognosis, disease progression, and as therapeutic response predictors in SSc. Ideally, for widespread utility, biomarkers should be easy to sample and analyse.ObjectivesWe aimed at evaluating potentially pathogenic circulating key cytokines/chemokines in a monocentric cohort of SSc patients.MethodsSera were drawn from SSc patients and 23 cytokines/chemokines (CCL2/MCP-1, IP-10/CXCL10, Flt3 Ligand, IFNa2, IL6, IL7, IL12, IL13, IL15, IL17A, TNFa, IL-1Ra, CXCL13, IL21, IL23, IL33, TSLP, IL-2RA, IL1RII, TNFRII, BAFF, CCL19/MIP-3B 66, MMP-8) were quantified using Luminex multiplex immunoassay (BioRad-BioPlex 200 System-Lumine x-Map technology R&D Systems, USA) following the manufacturer’s instructions and customized procedures. Data were acquired using Bioplex manager v 6.1. P value ≤ 0.05 was considered to be significant. Data were analyzed using GraphPad Prism V.8 (GraphPad Software, Inc.) software.ResultsClinical and demographic features of 17 SSc (5 dcSSc, 12 lcSSc) patients are reported in Table 1. Mean±SD age was 55±14.68 years, mean±SD disease duration was 89.47±95.34 months. We found that MCP-1 levels inversely correlated with PAPs (r=-0.55, P=0.03) and IP10 with anti-Scl70 (r=-0.561, P=0.004), Figure 1. No other associations were foundTable 1.N%Sex2M/15F11.8/88.32Age (years, mean±SD)55±14.68Disease duration (months, mean±SD)89.47±95.34Cigarette smoke847Raynaud’s phenomenon17100Skin thickening1482.4Ulcers211.8Rodnan’s Skin Score (mean±SD)5.9±6.6Articular involvement211.8Heart involvement00Paps max (mmhg, mean±SD)28.3±5.9Pulmonary involvement529.4DLCO min (%, mean±SD)90.24±21.2Gastrointestinal involvement317.6ANA17100Rheumatoid factor423.5Anti-Scl70 (U/ml, mean±SD)33.2±59.3Anti-CENP(U/ml, mean±SD)55.9±48.9Anti-SSA211.8Anti-SSB15.9Anti-Sm15.9Anti-RNP15.9Elevated Blood Pressure423.5Obesity15.8Any DMARD529.4ConclusionWe confirm a potential pathogenic role for MCP-1 in SSc. The -2518 promotor polymorphism in the MCP-1 gene has been already associated with disease susceptibility and an increased expression of the molecule both in peripheral blood and in the skin has been described. Intriguingly, MCP-1 seems to drive skin fibrosis while the role played in pulmonary involvement is more controversial. Indeed, similarly to our results, Scala et al. found an inverse correlation between pulmonary fibrosis and MCP-1 from T cell lines (1). At the same extent, the observation that IP-10 has an inverse correlation with anti-Scl70 levels is not novel and the usage of this chemokine as a marker of lcSSc has been already suggested. In this view, Zhu et al. found that Scl-70 negative patients have a higher expression of IP-10 than Scl-70 positive (1,878 (2,964) ng/L vs 1,030 (2,196.6) ng/L, P<0.05) (2). Finally, this is the first report on MMP8 in SSc and we suggest that MMP8 - a collagenase and marker of idiopathic pulmonary fibrosis involved in the migration of fibroblasts - can represent a promising biomarker for SSc diagnosis.References[1]Scala et al. Clin Exp Immunol 2004[2]Beijing Da Xue Xue Bao Yi Xue Ban. 2019Figure 1.Disclosure of InterestsNone declared

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Li, Hsin-Hua, Hanoch Livneh, Wei-Jen Chen, Ming-Chi Lu, Wen-Yen Chiou, Shih-Kai Hung, Chia-Chou Yeh, and Tzung-Yi Tsai. "Chinese Herbal Medicine to Reduce Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients: Evidence From Population-Based Health Claims." Integrative Cancer Therapies 20 (January 2021): 153473542110448. http://dx.doi.org/10.1177/15347354211044833.

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Background: Subjects with head and neck cancer (HNC) often experience post-treatment side effects, particularly radiation-induced oral mucositis (RIOM). This study aimed to explore the association of Chinese herbal medicine use with the sequent risk of RIOM among them. Methods: This cohort study used a nationwide health insurance database to identify subjects newly diagnosed with HNC, aged 20 to 60 years, who received treatment between 2000 and 2007. Among them, a total of 561 cases received CHM after HNC onset (CHM users); the remaining 2395 cases were non-CHM users. All patients were followed to the end of 2012 to identify any treatment for RIOM as the end point. Cox proportional hazards regression was used to compute the adjusted hazard ratio (aHR) of RIOM by CHM use. Results: During the follow-up period, 183 CHM users and 989 non-CHM users developed RIOM at incidence rates of 40.98 and 57.91 per 1000 person-years, respectively. CHM users had a lower RIOM risk than the non-CHM users (aHR: 0.68; 95% Confidence Interval: 0.58-0.80). The most potent effect was observed in those taking CHM for more than 1 year. Use of Baizhi, Danshen, Shao-Yao-Gan-Cao-Tang, Gan-Lu-Yin, Huangqin, Shu-Jing-Huo-Xue-Tang, and Xin-Yi-Qing-Fei-Tang, was significantly related to a lower risk of RIOM. Conclusion: Findings of this study indicated that adding CHM to conventional clinical care could be helpful in protecting those with HNC against the onset of RIOM. Further clinical and mechanistic studies are warranted.

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Lin, Jia-Yi, Wei-Wei Zhang, Qing-Jie Li, Xue-Liang Fang, Jun-Yan Li, Shi-Wei He, Ying-Qin Li, et al. "Abstract 1113: USP18 impairs the sensitivity of radiotherapy for nasopharyngeal carcinoma by promoting the ubiquitination and nuclear translocation of TRIM29." Cancer Research 84, no. 6_Supplement (March 22, 2024): 1113. http://dx.doi.org/10.1158/1538-7445.am2024-1113.

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Abstract Radiotherapy is the main and preferred treatment for nasopharyngeal carcinoma (NPC), owing to its high sensitivity to radiation. However, there are ~20% patients suffering from tumor recurrence. Accumulating evidences show that protein ubiquitination plays a vital role in radiation caused DNA damage response. Here, we identified that the deubiquitinase USP18 is highly expressed in NPC tissues, and inversely associated with radiosensitivity of NPC cells. USP18 interacts with TRIM29 and promotes its K27-linked ubiquitination independent of its deubiquitinase activity. Further investigation reveals that USP18 acts as a scaffold to recruit the E3 ubiquitin ligase TRIM21 to directly ubiquitinate TRIM29 at Lys307, thus promoting its oligomerization and nuclear translocation, and thereby facilitates the DNA damage repair of NPC cells after irradiation. Clinically, higher expression of USP18 indicates poor response to radiotherapy and worse prognosis in NPC patients. Our findings reveal the critical role of USP18 in regulating radiosensitivity, and targeting USP18-TRIM21-TRIM29 axis maybe a novel strategy to synergize with radiotherapy for NPC patients. Citation Format: Jia-Yi Lin, Wei-Wei Zhang, Qing-Jie Li, Xue-Liang Fang, Jun-Yan Li, Shi-Wei He, Ying-Qin Li, Jun Ma, Na Liu, Yin Zhao, Rui Guo. USP18 impairs the sensitivity of radiotherapy for nasopharyngeal carcinoma by promoting the ubiquitination and nuclear translocation of TRIM29 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1113.

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Li, Qing-Jie, Xue-Liang Fang, Ying-Qin Li, Jia-Yi Lin, Cheng-Long Huang, Shi-Wei He, Sheng-Yan Huang, et al. "Abstract 1999: DCAF7 acts as a scaffold to recruit USP10 for G3BP1 deubiquitylation and facilitates chemoresistance and metastasis in nasopharyngeal carcinoma." Cancer Research 84, no. 6_Supplement (March 22, 2024): 1999. http://dx.doi.org/10.1158/1538-7445.am2024-1999.

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Abstract Though docetaxel plus cisplatin and 5-fluorouracil (TPF) induction chemotherapy becomes the standard care for locoregionally advanced nasopharyngeal carcinoma (NPC), some patients could not benefit from this therapy. The underlying mechanisms remain unclear. We found that DCAF7 was highly expressed in TPF resistant NPC patients, and promoted the cisplatin resistance and metastasis of NPC cells. Mechanistically, DCAF7 facilitates the interaction between USP10 and G3BP1, resulting in the removal of K48-linked ubiquitylation of G3BP1 at Lys76 mediated by USP10, thus preventing the degradation of G3BP1 through ubiquitin-proteasome pathway, and facilitates the stress granule (SG)-like structures formation. Moreover, knockdown of G3BP1 successfully reversed the SG-like structures formation and oncogenic effects exerted by DCAF7. Importantly, NPC patients with elevated DCAF7 expression exhibited high risks of metastasis, and is associated with a poor prognosis. This study identifies DCAF7 as a pivotal cisplatin resistance gene, and sheds light on the underlying mechanism of TPF resistance in NPC patients. The DCAF7-USP10-G3BP1 axis provides potential therapeutic targets and biomarker for NPC treatment. Citation Format: Qing-Jie Li, Xue-Liang Fang, Ying-Qin Li, Jia-Yi Lin, Cheng-Long Huang, Shi-Wei He, Sheng-Yan Huang, Jun-Yan Li, Sha Gong, Kai-Lin Chen, Na Liu, Jun Ma, Yin Zhao, Ling-Long Tang. DCAF7 acts as a scaffold to recruit USP10 for G3BP1 deubiquitylation and facilitates chemoresistance and metastasis in nasopharyngeal carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1999.

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Lin, Chih-lung. "Book Review: Jin dai tai wan zao chuan ye de ji shu zhuan yi yu xue xi (The Shipbuilding Industry in Modern Taiwan: Technology Transfer and Learning)." International Journal of Maritime History 24, no. 2 (December 2012): 343–45. http://dx.doi.org/10.1177/084387141202400245.

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Wang, Li-Li, and Hai-Feng Cao. "Content features of medical journal Zhong Xi Yi Xue Bao (《中西医学报》 The International Medical Journal) during the Republican period and its impact on medicine." Chinese Medicine and Culture 4, no. 1 (2021): 66. http://dx.doi.org/10.4103/cmac.cmac_9_21.

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Dorsey, John G. "Editorial on “Microfluidics-to mass spectrometry: A review of coupling methods and applications” by Xue Wang, Lian Yi, Nikita Mukhitov, Adrian M. Schrell, Raghuram Dhumpa and Michael G. Roper." Journal of Chromatography A 1382 (February 2015): 97. http://dx.doi.org/10.1016/j.chroma.2014.11.054.

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Lu, Martin. "Guodian Bamboo Texts and Pre-Qin Intellectual Thoughts (Guo Dian Zhu Jian Yu Xian Qin Xue Shu Si Xiang).a By Guo Yi. b (Shanghai: Shanghai Educational Publishing House, 2001. 859 pp.)." Journal of Chinese Philosophy 31, no. 2 (February 19, 2004): 297–301. http://dx.doi.org/10.1163/15406253-03102008.

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Lewis, John W., and Xue Litai. "Jifeng Liu;, Yanqiong Liu;, Haiyan Xie. Liang dan yi xing gong cheng yu da ke xue [The Project of “Two Bombs, One Satellite”: A Model of the Big Science]. (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.). 254 pp., illus., tables, bibl., index. Jinan: Shandong jiao yu chu ban she [Shandong Education Press], 2004. ¥27 (paper)." Isis 99, no. 2 (June 2008): 430–31. http://dx.doi.org/10.1086/591370.

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Wang, Zuoyue. "Jian Zhang. Ke xue she tuan zai jin dai Zhongguo de ming yun: yi Zhongguo ke xue she wei zhong xin [The Science Association and the Change of Society in Modern China: A Study on the Science Society of China]. (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.). 460 pp., tables, bibl., index. Jinan: Shandong jiao yu chu ban she [Shandong Education Press], 2005. ¥49 (paper)." Isis 99, no. 2 (June 2008): 437–38. http://dx.doi.org/10.1086/591376.

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Geunsik Seo. "Xinghuxuepai(星湖學派) process of the formation of the Dasan Jeong Yak - Yong' Yi Xue(易學)(Ⅱ) - The Interpretation Methods of Zhouyi(『周易』) in Ha - bin Shin Hu - Dam)'s ZhouYiXiangCiXinBian." JOURNAL OF KOREAN PHILOSOPHICAL HISTORY ll, no. 48 (February 2016): 161–90. http://dx.doi.org/10.35504/kph.2016..48.006.

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Gonçalves, Gabriela Sumie Yaguinuma, Tayna Natsumi Takakura, Anderson Catelan, Rosalinda Tanuri Zaninotto Venturim, Carolina dos Santos Santinoni, and Christine Men Martins. "Tratar ou extrair? Tratamento de lesão endoperiodontal, um relato de caso clínico." ARCHIVES OF HEALTH INVESTIGATION 9, no. 6 (April 20, 2020): 535–40. http://dx.doi.org/10.21270/archi.v9i6.4814.

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Introdução: Lesões endoperiodontais são lesões originadas de produtos inflamatórios encontrados tanto em periodonto quanto em polpa. Tais lesões podem se originar devido a uma infecção pulpar ou periodontal. Visando o prognóstico favorável, é imprescindível o conhecimento da etiologia, realização do correto diagnóstico e elaboração do plano de tratamento que envolve o tratamento endodôntico precedido do tratamento periodontal. Objetivo: O propósito do presente trabalho foi de relatar um caso clínico de lesão endoperiodontal e o tratamento realizado. Relato de caso clínico: Paciente gênero feminino, 51 anos, compareceu à clínica com uma fístula na região do dente 46, procedeu-se com exame radiográfico, rastreamento de fístula, testes endodônticos e avaliação periodontal. Foi diagnosticada lesão endoperiodontal. Executou-se, então, o tratamento endodôntico em sessões múltiplas, utilizando hidróxido de cálcio como medicação intracanal e o tratamento periodontal concomitante; finalizou-se endodontia obturando-se os canais radiculares. Conclusão: Observou-se, no controle, que a associação de tratamentos foi eficaz e houve melhora significativa do quadro, constatando-se silêncio clínico e sucesso do tratamento. Realizar o tratamento conservador a despeito da exodontia foi a melhor escolha para a paciente. Descritores: Endodontia; Periodontia; Polpa Dentária; Periodonto. Referências Sunitha VR, Emmadi P, Namasivayam A, Thyegarajan R, Rajaraman V. The periodontal - endodontic continuum A review. J Conserv Dent. 2008;11(2):54-62. Betancourt P, Elgueta R, Fuentes R. Treatment of endo-periodontal lesion using leukocyte-platelet-rich fibrin - a case report. Colomb Med. 2017;48(4):204-7. Lopes HP, Siqueira JF. Endodontia: Biologia e Técnica. Rio de Janeiro: Medsi-Guanabara Koogan; 2015. Lindhe J, Karring T, Lang NP. Tratado de periodontia clínica e implantologia oral. Rio de Janeiro: Guanabara Koogan; 2010. Anand V, Govila V, Gulati M. Endo-perio lesion part II (the treatment) - a review. 2012;3(1):10-6. Rotstein I, Simon JH. Diagnosis, prognosis and decision-making in the treatment of combined periodontal-endodontic lesions. J Periodontol. 2004;34:165-203. Parolia A, Gait TC, Porto ICCM, Mala K. Endo-perio lesion: a dilemma from 19th until 21st century. J Interdisp Dent. 2013;3(1):2-11. Kim E, Song JS, Jung IY, Lee SJ, Kim S. Prospective clinical study evaluating endodontic microsurgery outcomes for cases with lesions of endodontic origin compared with cases with lesions of combined periodontal-endodontic origin. J Endod. 2008;34(5):546-51. Heasman PA. An endodontic conundrum: the association between pulpal infection and periodontal disease. Br Dent J. 2014;216(6):275-9. Schmidt JC, Walter C, Amato M, Weiger R. Treatment of periodontal-endodontic lesions--a systematic review. J Clin Periodontol. 2014; 41(8):779-90. Jivoinovici R, Suciu I, Dimitriu B, Perlea P, Bartok R, Malita M, Ionescu C. Endo-periodontal lesion--endodontic approach. J Med Life. 2014;7(4):542-44. Estrela C. Endodontia laboratorial e clínica, Série Abeno: Odontologia Essencial - Parte Clínica. São Paulo: Artes Médicas; 2013. Vera J, Siqueira JF Jr, Ricucci D, Loghin S, Fernández N, Flores B et al. One-versus two-visit endodontic treatment of teeth with apical periodontitis: a histobacteriologic study. J Endod. 2012;38(8):1040-52. Mohammadi Z, Dummer PMH. Properties and applications of calcium hydroxide in endodontics and dental traumatology. Inter Endod J. 2011;44(8):697-730. Batista VES, Olian DA, Mori GG. Diffusion of hydroxyl ions from calcium hydroxide and aloe vera pastes. Braz Dent J. 2014;25(3):212-16. Pereira TC, da Silva Munhoz Vasconcelos LR, Graeff MSZ, Ribeiro MCM, Duarte MAH, de Andrade FB. Intratubular decontamination ability and physicochemical properties of calcium hydroxidepastes. Clin Oral Investig. 2019;23(3):1253-62. Andolfatto C, da Silva GF, Cornélio AL, Guerreiro-Tanomaru JM, Tanomaru-Filho M, Faria G, Bonetti-Filho I, Cerri PS. Biocompatibility of intracanal medications based on calcium hydroxide. ISRN Dent. 2012;2012:904963. Duque TM, Prado M, Herrera DR, Gomes BPFA. Periodontal and endodontic infectious/inflammatory profile in primary periodontal lesions with secondary endodontic involvement after a calcium hydroxide-based intracanal medication. Clin Oral Investig. 2019;23(1):53-63. Kim D, Kim E. Antimicrobial effect of calcium hydroxide as an intracanal medicament in root canal treatment: a literature review - Part I. In vitro studies. Restor Dent Endod. 2014; 39(4):241-52. Adl A, Motamedifar M, Shams MS, Mirzaie A. Clinical investigation of the effect of calcium hydroxide intracanal dressing on bacterial lipopolysaccharide reduction from infected root canals. Aust Endod J. 2015;41(1):12-6. Hilton TJ, Ferracane JL, Mancl L; Northwest Practice-based Research Collaborative in Evidence-based Dentistry (NWP). Comparison of CaOH with MTA for direct pulp capping: a PBRN randomized clinical trial. J Dent Res. 2013;92(7 Suppl):16S-22S. Labban N, Yassen GH, Windsor LJ, Platt JA. The direct cytotoxic effects of medicaments used in endodontic regeneration on human dental pulp cells. Dent Traumatol. 2014;30(6):429-34. McIntyre PW, Wu JL, Kolte R, Zhang R, Gregory RL, Bruzzaniti A, Yassen GH. The antimicrobial properties, cytotoxicity, and differentiation potential of double antibiotic intracanal medicaments loaded into hydrogel system. Clin Oral Investig. 2019;23(3):1051-59. Bergenholtz, G., Hasselgren, G. Endodontics and periodontics. In: Lindhe, K., Karring, T., Lang, N. Clinical periodontology and implant dentistry. Copenhagen:Munksgaard; 2015. Harrington GW, Steiner DR, Ammons WF. The periodontal-endodontic controversy. Periodontol 2000. 2002;30:123-30. Fernandes LA, Martins TM, Almeida JM, Nagata MJ, Theodoro LH, Garcia VG, Bosco AF. Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats. J Appl Oral Sci. 2010;18(6):635-40. Storrer CM, Bordin GM, Pereira TT. How to diagnose and treat periodontal endodontic lesions? 2012;9(4):427-33. Verma PK, Srivastava R, Gupta KK, Srivastava A. Combined endodontic periodontal lesions: A clinical dilema. J Interdiscip Dent. 2011;1(2):119-24. Oh SL, Fouad AF, Park SH. Treatment strategy for guided tissue regeneration in combined endodontic-periodontal lesions: case report and review. J Endod. 2009;35(10):1331-36. Malli R, Lele P, Vishakha. Guided tissue regeneration in communicating periodontal and endodontic lesions - a hope for the hopeless. J Indian Soc Periodontol. 2011;15(4):410-13. Ghezzi C, Virzì M, Schupbach P, Broccaioli A, Simion M. Treatment of combined endodontic-periodontic lesions using guided tissue regeneration: clinical case and histology. Int J Periodontics Restorative Dent. 2012;32(4):433-9. Sun J, Liu Q. [Bio-Oss collagen bone grafting in the treatment of endodontic-periodontic lesion]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29(9):1905-6. Sharma R, Hegde V, Siddharth M, Hegde R, Manchanda G, Agarwal P. Endodontic-periodontal microsurgery for combined endodontic-periodontal lesions: An overview. J Conserv Dent. 2014;17(6):510-16. Li Y, Wang X, Xu J, Zhou X, Xie K. [The clinical study on the use of diode laser irradiation in the treatment of periodontal-endodontic combined lesions]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2012;30(2):161-64, 168. Narang S, Narang A, Gupta R. A sequential approach in treatment of perio-endo lesion. J Indian Soc Periodontol. 2011;15(2):177-80. Pereira AL, Orzechowski PR, Filho SB, Cortelli JR. Subepithelial connective tissue graft: an alternative application for treating endoperiodontal lesions. Gen Dent. 2013;61(2):50-3. Yoneda M, Motooka N, Naito T, Maeda K, Hirofuji T. Resolution of furcation bone loss after non-surgical root canal treatment: application of a peptidase-detection kit for treatment of type I endoperiodontal lesion. J Oral Sci. 2005; 47(3):143-47. Shenoy N, Shenoy A. Endo-perio lesions: diagnosis and clinical considerations. Indian J Dent Res. 2010;21(4):579-85. Gerritsen AE, Allen PF, Witter DJ, Bronkhorst EM, Creugers NH. Tooth loss and oral health-related quality of life: a systematic review and meta-analysis. Health Qual Life Outcomes. 2010;8:126.

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Mattie, Michael D., Regis Perbost, Sarah Turcan, Corinne Danan, Frederick L. Locke, Sattva S. Neelapu, David B. Miklos, et al. "Abstract 5879: Defining the cancer Immunogram using multimodal analysis to guide immunotherapy in diffuse large B cell lymphoma." Cancer Research 83, no. 7_Supplement (April 4, 2023): 5879. http://dx.doi.org/10.1158/1538-7445.am2023-5879.

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Abstract (a) Expansion of therapeutic strategies against diffuse large B-cell lymphoma (DLBCL) offers new opportunities to fight aggressive non-Hodgkin's lymphoma. Therapy approaches, such as R-CHOP and stem cell transplant, and CAR-T cell therapies are now available for the treatment of DLBCL. While the role of the tumor microenvironment (TME) during the therapeutic response is now recognized, the spatial organization and the communication between the diverse factors that compose the TME remains to be fully understood. In this study, we describe a new immunogram tool to help clinical researchers measure the tumor microenvironment contribution to drug efficacy or toxicity in DLBCL context. (b) In a previous work, using a high-quality testing and innovative multimodal and integrative approach, we constructed the first Veracyte Biopharma Atlas for DLBCL lesions. Based on this knowledge and the understanding of the immune contexture of tumors, we constructed an immunogram using the scoring of clinically relevant biomarkers. Our immunogram scoring approach is composed of key features driving computational derivation of DLBCL Atlas clusters, which include immune gene signatures, immune cell phenotyping combined with spatial information, and genomic and clinical parameters. (c) Patterns that strongly associated with CAR-T treatment response were determined. In addition, promising results have been obtained in the prediction to CAR-T toxicity related to T-regulatory cells or R-CHOP response with transcriptomic signature. (d) Retrospective analysis of CAR-T clinical trial data and tumor biopsies highlighted the Veracyte Immunogram as a powerful tool to score the patient probability of response to CAR-T. This work provides the framework for identification of predictors of response to therapy, potential targets of interest or biomarkers that could be applied in future clinical trials. Citation Format: Michael D. Mattie, Regis Perbost, Sarah Turcan, Corinne Danan, Frederick L. Locke, Sattva S. Neelapu, David B. Miklos, Caron A. Jacobson, Lazaros J. Lekakis, Yi Lin, Armin Ghobadi, Jenny J. Kim, Zixing Wang, Allen Xue, Simone Filosto, Nathalie Scholler, Jerome Galon. Defining the cancer Immunogram using multimodal analysis to guide immunotherapy in diffuse large B cell lymphoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5879.

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Zhang, H. "The “Xie Yi” style of Dai Shihe Works." Университетский научный журнал, no. 51 (2019): 183–98. http://dx.doi.org/10.25807/pbh.22225064.2019.51.183.198.

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Wang, Na, Ruiming Liu, Jinglin Lu, Peng Quan, and Zongfu Mao. "The Research on the Outpatient Cost Adjustment Framework of the Urban Workers in a Southern China City During 2013 to 2015." INQUIRY: The Journal of Health Care Organization, Provision, and Financing 56 (January 2019): 004695801989409. http://dx.doi.org/10.1177/0046958019894093.

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Based on a large amount of data, the study aimed to analyze all expenses of outpatients in a southern China city from 2013 to 2015. It draws a conclusion that the total cost of outpatient has increased in the past 3 years, and various cost indexes either increased or decreased in different ways. Drug costs and treatment fees are the main influencing factors for the change in total outpatient cost. The structural change from 2013 to 2015 was 70.15%. Drug costs, laboratory fees, and inspection fees are the main indexes that account for the increasing total outpatient costs. This study puts emphasis on the cost of human resources, which eliminates the phenomenon of “Yi Yao Yang Yi” (support medical cost with medicine) and “Yi Xie Yang Yi” (support medical cost with medical device). This study also focuses on the balance of outpatient cost, as well as the compensation function of medical insurance, which encourages multiple participation and coordinated adjustment.

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Geunsik Seo. "Xinghuxuepai(星湖學派) process of the formation of the Dasan Jeong Yak-Yong(茶山丁若鏞)' Yi Xue(易學) - The Interpretation Methods of Zhouyi({周易}) in Seong-ho Lee Ik(星湖李瀷)'s YiJingJiShu({易經疾書})." JOURNAL OF KOREAN PHILOSOPHICAL HISTORY ll, no. 44 (March 2015): 61–88. http://dx.doi.org/10.35504/kph.2015..44.003.

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Schmalzer, Sigrid. "Weimin Xiong;, Kedi Wang. He cheng yi ge dan bai zhi: Jie jing niu yi dao su de ren gong quan he cheng [Synthesize a protein: The story of total synthesis of crystalline insulin project in China]. (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.). 194 pp., figs., bibl., app., index. Jinan: Shandong jiao yu chu ban she [Shandong Education Press], 2005. $25 (paper)." Isis 99, no. 1 (March 2008): 231–32. http://dx.doi.org/10.1086/589404.

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Bao, Hua, Xiaoxi Chen, Min Wu, Shiting Tang, Xuxiaochen Wu, Wanxiangfu Tang, Dongqin Zhu, et al. "Abstract 1266: Development and performance of a multi-cancer early detection test utilizing plasma cfDNA fragmentomics: A large-scale, prospective, multicenter study." Cancer Research 84, no. 6_Supplement (March 22, 2024): 1266. http://dx.doi.org/10.1158/1538-7445.am2024-1266.

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Abstract Background: The implementation of the multi-cancer early detection (MCED) test offers a valuable adjunct to existing screening methods, enabling more efficient detection of cancer and potentially leading to improved treatment outcomes and prognoses for patients. Here, we report on the performance of an MCED test, which utilizes plasma cfDNA and leverages genome-wide fragmentomics-based characteristics to identify cancer signals and predict the signal origin across a diverse range of cancer types. Methods: Plasma cfDNA from evaluable blood samples was analyzed using an MCED blood test called MERCURY, a robust machine learning classifier leveraging the low-coverage whole-genome sequencing and a comprehensive set of genome-wide features derived from cfDNA fragmentomics. A carefully selected cohort of 3076 cancer patients representing 13 cancer types, in addition to 3477 healthy controls, were pre-specified into the training and internal validation sets to train and internally validate the models to assess cancer and tissue of origin (TOO). The classifier was trained to a target specificity of 99% and locked before analysis of the independent validation set. The independent validation was enrolled prospectively and consists of 1465 participants (cancer: n= 732; non-cancer: n= 733). Results: The performance metrics in the internal validation set demonstrated that the sensitivity and specificity for cancer detection were 0.865 (95% CI [0.840, 0.887]) and 0.989 (95% CI [0.980, 0.994]), respectively. These impressive results were further substantiated in the independent validation set, where the overall sensitivity and specificity were found to be 0.874 (95% CI [0.848, 0.897]) and 0.978 (95% CI [0.965, 0.987]) respectively. Notably, the sensitivity showed an incremental increase with the stage of cancer (Stage I: 0.769, 95% CI [0.708, 0.821]; Stage II: 0.840, 95% CI [0.784, 0.886]; Stage III: 0.923, 95% CI [0.874, 0.954]; Stage IV: 0.971, 95% CI [0.901, 0.995]. Regarding the TOO model, a total of 10 cancer types with more than 100 patients in the model construction cohort were considered. The TOO model achieved a prediction accuracy of 83.5% (95% CI [80.7%, 86.6%]) and 91.8% (95% CI [89.6%, 94.1%]) for the top predicted origin and the top two predicted origins, respectively, amongst the true positive cases in the independent validation set. Conclusions: In this pre-specified, large-scale study, the MCED test, utilizing cfDNA fragmentomics, demonstrates its remarkable ability to assess cancer signal with an elevated level of sensitivity and specificity across 13 distinct types of cancer. Moreover, it displays noteworthy accuracy in predicting the tissue of origin. The performances are to be further validated in a prospective cohort study (NCT06011694). Citation Format: Hua Bao, Xiaoxi Chen, Min Wu, Shiting Tang, Xuxiaochen Wu, Wanxiangfu Tang, Dongqin Zhu, Shanshan Yang, Shuang Chang, Peng He, Xiuxiu Xu, JinPeng Zhang, Yi Shen, Shuyu Wu, Ya Jiang, Sisi Liu, Xian Zhang, Xue Wu, Yang Shao. Development and performance of a multi-cancer early detection test utilizing plasma cfDNA fragmentomics: A large-scale, prospective, multicenter study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1266.

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Huang, Weiwei. "THE NOTIONS OF XIE-SHI («WRITING REALITY»), XIE-YI («WRITING IDEA») AND THEIR RELATIONSHIP TO REALISM." Scientific and analytical journal Burganov House. The space of culture 19, no. 6 (December 10, 2023): 10–16. http://dx.doi.org/10.36340/2071-6818-2023-19-6-10-16.

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This article discusses terminological problems in the context of contemporary art practice and theory in China. Contemporary Chinese sculpture criticism has evolved in the context of certain influence of Western theories of art. Against the background of the integration of Western theories and terminology system of sculpture in the present stage, the Chinese sculpture community has perceived and internalized terms such as realism, depiction, figurative, abstract, and so on. This has greatly enriched the theory and practice of Chinese sculpture. At the same time, there are sculptural terms rooted in the Chinese national art practice, such as “xie-shi” and “xie-yi”. Unfortunately, limited by the cultural and linguistic contexts of China and the West, and by the fact that most Chinese sculptors still preserve the creative habit of relying on traditional experience and personal judgment, these terms lead to vagueness and speculation in defining the type of sculptural artwork. This situation can very easily lead to ambiguity and misinterpretation in interlingual translation, which becomes an obstacle to the understanding of Chinese sculptural art in other countries and limits the development of Chinese sculptural criticism. This is an important academic problem that requires long-term research. The author would like to express his gratitude to Prof. Maria Burganova for drawing his attention to this problem. According to the results of the author's search in the Chinese full-text database of periodicals, master's theses and doctoral dissertations CNKI, there are still no papers on Chinese art history specifically dealing with this relevant topic, which remains to be explored.

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Uchanska-Ziegler, B. "Response to Xie and Yi: Ankylosing spondylitis: a β2m-deposition disease?" Trends in Immunology 24, no. 5 (May 2003): 229–30. http://dx.doi.org/10.1016/s1471-4906(03)00078-4.

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Baykal, F., S. Erten, S. C. Güven, A. Kor, F. Eren, S. Neşelioğlu, B. Polat, et al. "AB1059 NETRIN-1 IN SPONDYLOARTHRITIS: A NOVEL MARKER TO PREDICT DISEASE ACTIVITY?" Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 1751.2–1751. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6349.

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BackgroundNetrin-1 is a chemorepulsant and inhibits the migration of monocytes, neutrophils and lymphocytes by activation of its receptors. It has been revealed that netrin-1 can limit the inflammatory response, reduce tissue damage due to hypoxia and simultaneously suppress apoptosis. Due to this immune regulatory role, it has been hypothesized that netrin-1 can be used as a biomarker in rheumatic diseases.ObjectivesTo compare plasma netrin-1 levels in axial spondyloarthritis (SpA) patients with the healthy subjects and to evaluate its relationship with disease activity and other clinical and laboratory parameters.MethodsPatients with axial SpA between the ages of 18-65 who applied to Ankara City Hospital Rheumatology outpatient clinic between November 2021 and January 2022 were consecutively enrolled upon acceptance to participate. Pregnant patients, patients with systemic disease other than axial SpA and patients who were taking regular medication other than axial SpA treatment were excluded. A control group was formed from healthy volunteers with similar age and gender characteristics. In both groups, in addition to regular laboratory tests netrin-1 level was measured by an Enzyme Linked ImmunoSorbent Assay (ELISA) kit with an analytical unit of pg/mL (Elabscience, Texas, USA, Catalog No: E-EL-H2328; Lot No: GZWTKZ5SWK).ResultsA total of 60 axial SpA patients and 56 healthy controls were included in the study. There was no statistically significant difference between the groups in terms of age, gender andnetrin-1 levels between patients and controls (Table 1). Data regarding clinical characteristics, HLA-B27 positivity, acute phase reactants at the time of evaluation and disease activity scores of the axial SpA group was presented in Table 1. No significant differences were observed in netrin-1 levels in any comparison among all axial SpA patients, in ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (nr-ax SpA) patient subgroups, and in healthy controls (all axial SpA vs control p=0,361, AS vs nr-axSpA p=0,790, AS vs control p=0,360, nr-axSpA vs control p=0,700). Netrin-1 levels had a significant positive correlation with BASDAI (r=0,301 p=0,032), ASDAS CRP (r=0,320 p=0,022), VAS pain (r=0,340 p=0,015).ConclusionOur results demonstrated a positive correlation between netrin-1 levels and disease activity in axial SpA patients, implying that netrin-1 may come to the forefront as a novel biomarker to predict disease activity in axial SpA.References[1]Tang Z, Xu C, Zhang G, Chen H. [Protect role of Netrin-1 in inflammatory response]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2016 Aug;28(8):756-60. Chinese. doi: 10.3760/cma.j.issn.2095- 4352.2016.08.020. PMID: 27434573.[2]Ranganathan PV, Jayakumar C, Mohamed R, Dong Z, Ramesh G. Netrin-1 regulates the inflammatory response of neutrophils and macrophages, and suppresses ischemic acute kidney injury by inhibiting COX-2-mediated PGE2 production. Kidney İnternational 2013;83(6):1087-1098.Table 1.Demographics of subject groups, clinical and laboratory characteristics of axial SpA patientsAxial SpA N=60Control N=56PAge, years, mean ± SD39,51 ± 10,8844,57 ± 13,870,057Gender, female, n (%)37 (53,6)32 (46,4)0,620Type of axial SpA, n (%) AS49 (81,66) Nr-ax SpA11 (18,33)HLA-B27 positivity, n (%)*22 (64,7)CRP, mg/L, mean ± SD8,09 ± 9,30ESR, mm/hour, years, mean ± SD13,4 ± 10,95Morning stiffness time, hours, mean ± SD1,6 ± 2,72VAS pain, mean ± SD4,11 ± 2,75BASDAI, mean ± SD3,00 ± 2,04ASDAS CRP, mean ± SD2,30 ± 1,04Serum Netrin-1, pg/mL, mean (min-max)74,436 (34,5-237,18)61,904 (35,85-175,33)0,361* Out of 34 patients with a HLA-B27 test result, SpA: spondyloarthritis, AS: ankylosing spondylitis, Nr-ax SpA: non-raidographic axial spondyloarthritis, HLA-b27: human leukocyte antigen B27, CRP: C-reactive protein, ESR: erythrocyte sedimentation rate, VAS: visual analogue scale, BASDAI: Bath Ankylosing Spondylitis Disease Activity Index, ASDAS CRP: Ankylosing Spondylitis Disease Activity Score CRPAcknowledgements:NIL.Disclosure of InterestsNone Declared.

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Lin, Yongchao. "Xie-yi Traditions in Modern Chinese Still Life in Oil Painting Technique." Университетский научный журнал, no. 61 (2021): 150–67. http://dx.doi.org/10.25807/22225064_2021_61_150.

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ZHANG, YOU-YUAN, GANG XIE, and NIAN-HE XIA. "Yushania tongziensis (Poaceae, Bambusoideae), a new bamboo species from north Guizhou, China." Phytotaxa 618, no. 1 (September 29, 2023): 86–92. http://dx.doi.org/10.11646/phytotaxa.618.1.8.

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Yushania tongziensis N.H. Xia, Y.Y. Zhang et G. Xie, a new species of temperate woody bamboo tribe Arundinarieae (Poaceae: Bambusoideae), is described and illustrated from north Guizhou, China. The new species is morphologically similar to Y. panxianensis T.P. Yi et J.J. Shi, but differs in having culm internodes smooth, deciduous culm leaf sheaths, oral setae absent, ligules ca. 1 mm tall (vs. 1.5‒3 mm), pseudopetioles 1‒1.5 mm long (vs. 1 mm) and transverse veins inconspicuous of leaf blade. Based on the morphological features, this new species is assigned to section Brevipaniculatae.

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Lavine, Barry K. "Chemometrics: From Basics to Wavelet Transform. Chemical Analysis, Volume 164 By Foo-Tim Chau (Hong Kong Polytechnic University), Yi-Zeng Liang (Central South University), Junbin Gao (University of New England), and Xue-Guang Shao (University of Science and Technology of China). John Wiley & Sons, Inc.: Hoboken, NJ. 2004. xiv + 316 pp. $99.95. ISBN 0-471-20242-8." Journal of the American Chemical Society 127, no. 7 (February 2005): 2365–66. http://dx.doi.org/10.1021/ja040937q.

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Hong, Seukpyo. "Yi Yuk-sa(이육사)’s Acceptance of Nietzsche, and Lu Xun(魯迅)." Journal of Modern Chinese Literature 95 (October 31, 2020): 175–210. http://dx.doi.org/10.46487/jmcl.2020.10.95.175.

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