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Journal articles on the topic 'Young and old mice'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Le Bras, Alexandra. "Old blood for young mice." Lab Animal 51, no. 9 (2022): 238. http://dx.doi.org/10.1038/s41684-022-01044-6.

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Le Bras, Alexandra. "Young blood for old mice." Lab Animal 48, no. 4 (2019): 113. http://dx.doi.org/10.1038/s41684-019-0280-3.

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Lynch, G. S., J. A. Rafael, R. T. Hinkle, N. M. Cole, J. S. Chamberlain, and J. A. Faulkner. "Contractile properties of diaphragm muscle segments from old mdx and old transgenic mdx mice." American Journal of Physiology-Cell Physiology 272, no. 6 (1997): C2063—C2068. http://dx.doi.org/10.1152/ajpcell.1997.272.6.c2063.

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Diaphragm muscles of young (4- to 6-mo-old) mdx mice show severe fiber necrosis and have normalized forces and powers 60 and 46% of the values for control C57BL/10 mice. In contrast, microinjection of mdx mouse embryos with a truncated dystrophin minigene has produced young transgenic mdx (tg-mdx) mice with a level of dystrophin expression and structural and functional properties of diaphragm muscle strips measured in vitro not different from those of control mice. Whether dystrophin expression and functional corrections persist for the life span of these animals is not know. We tested the nul

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Dalmer, Antonia, Paul Wörner, Mathias Manzke, et al. "Comparison of Myocardial Function in Young and Old Mice During Acute Myocardial Infarction: A Cardiac Magnetic Resonance Study." Diagnostics 15, no. 12 (2025): 1447. https://doi.org/10.3390/diagnostics15121447.

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Background/Objectives: This study aimed to compare changes in functional and strain parameters in young and old mice using cardiac MRI before and shortly after myocardial infarction. Methods: In this prospective experimental study, 7 young mice and 10 old mice underwent a cardiac MRI 5 days before and 2 days after myocardial infarction by LAD ligation. Functional parameters such as EDV, ESV, EF, SV, and Strain were determined. Results: EDV in the young mice before LAD ligation was significantly lower than in the old mice (p-value 0.002). EDV significantly increased after infarction in both gro

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M Gbaj, Abdul, Emhemmed Ali Elgallal, Inass A Sadawe, et al. "Immunogenicity and Safety of Sinopharm Covid-19 Vaccine in Young Mice." International Journal of Clinical Case Reports and Reviews 10, no. 3 (2022): 01–03. http://dx.doi.org/10.31579/2690-4861/185.

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Background and Aim: Vaccines to prevent SARS-CoV-2 infection may be considered a promising way for reduction of the pandemic. Many different vaccines have become obtainable for use in many countries. The present study aims to evaluate the immune response and the safety of Sinopharm COVID-19 vaccine on 14 days old mice. Materials and Methods:Our experimental study was performed on two weeks old mice, selected by random allocation. The mice were divided into three groups of 12. Group one received asingle dose of 0.5 ml Sinopharm COVID-19 vaccine, group two received two doses of 0.5 ml Sinopharm

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Zhou, T., C. K. Edwards, and J. D. Mountz. "Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice." Journal of Experimental Medicine 182, no. 1 (1995): 129–37. http://dx.doi.org/10.1084/jem.182.1.129.

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T cell dysfunction and thymic involution are major immunologic abnormalities associated with aging. Fas (CD95) is a bifunctional molecule that is critical for apoptosis and stimulation during T cell development, but the role of Fas during aging has not been determined. Fas expression and function on T cells from old (22-26-mo-old) mice was compared with young (2-mo-old) mice and old CD2-fas-transgenic mice. Fas expression and ligand-induced apoptosis were decreased on T cells from old mice compared with young mice. This correlated with an age-related increase in CD44+Fas- T cells. There was a

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Løvik, M., and R. J. North. "Effect of aging on antimicrobial immunity: old mice display a normal capacity for generating protective T cells and immunologic memory in response to infection with Listeria monocytogenes." Journal of Immunology 135, no. 5 (1985): 3479–86. http://dx.doi.org/10.4049/jimmunol.135.5.3479.

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Abstract Old (19 to 30 mo) and young adult (11 to 16 wk) AB6F1 mice of both sexes were compared in terms of their capacity to resist infection with Listeria monocytogenes. The LD50 was found to be two to four times higher for old than for young mice, and the time to death was longer for old mice. Enumeration of bacteria in the livers and spleens showed that old mice restricted growth of Listeria more effectively than young mice during the preimmune phase of infection, the difference being detectable as early as 12 to 24 hr after bacterial inoculation. Therefore, to ensure a similar level of in

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Wu, Dayong, Casilda Mura, Alison A. Beharka, et al. "Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E." American Journal of Physiology-Cell Physiology 275, no. 3 (1998): C661—C668. http://dx.doi.org/10.1152/ajpcell.1998.275.3.c661.

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We previously showed that increased macrophage and PGE2 production with age is due to enhanced cyclooxygenase (COX) activity and COX-2 expression. This study determined the effect of vitamin E supplementation on macrophage PGE2 synthesis in young and old mice and its underlying mechanism. Mice were fed 30 or 500 parts per million vitamin E for 30 days. Lipopolysaccharide (LPS)-stimulated macrophages from old mice produced significantly more PGE2 than those from young mice. Vitamin E supplementation reversed the increased PGE2 production in old mice but had no effect on macrophage PGE2productio

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Erzar, Eva, Mojca Kerec Kos, Katja Lakota, Peter Veranič, and Andreja Erman. "Does the Urothelium of Old Mice Regenerate after Chitosan Injury as Quickly as the Urothelium of Young Mice?" International Journal of Molecular Sciences 21, no. 10 (2020): 3502. http://dx.doi.org/10.3390/ijms21103502.

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The aging of organisms leads to a decreased ability of tissue to regenerate after injury. The regeneration of the bladder urothelium after induced desquamation with biopolymer chitosan has been studied in young mice but not in old mice. Chitosan is a suitable inducer of urothelial desquamation because it is known to be non-toxic. We used chitosan for desquamation of urothelial cells in order to compare the dynamics of urothelial regeneration after injury between young and old mice. Our aim was to determine whether the urothelial function and structure of old mice is restored as fast as in youn

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Tripathi, Deepak, Elwyn Welch, Satyanarayana Swamy Cheekatla та ін. "ALCOHOL ENHANCES TYPE 1 INTERFERON-α AND MORTALITY OF YOUNG MICE INFECTED WITH Mycobacterium tuberculosis". Journal of Immunology 200, № 1_Supplement (2018): 114.14. http://dx.doi.org/10.4049/jimmunol.200.supp.114.14.

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Abstract In the current study, we determined the effects of chronic alcohol consumption on the mortality of young and old mice and immune responses during Mycobacterium tuberculosis (Mtb) infection. Eighty percent of Mtb H37Rv infected alcohol-fed young mice died in five months compared to twenty-five percent in Mtb infected alcohol-fed old mice. There is no significant difference in lung bacterial burden of control and alcohol diet fed young and old mice. IFN-α levels were significantly higher in the lungs of Mtb infected alcohol-fed young mice and treatment with anti-IFNAR-1 antibody enhance

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Brooks, S. V., and J. A. Faulkner. "Contraction-induced injury: recovery of skeletal muscles in young and old mice." American Journal of Physiology-Cell Physiology 258, no. 3 (1990): C436—C442. http://dx.doi.org/10.1152/ajpcell.1990.258.3.c436.

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We tested the hypothesis that after the same amount of contraction-induced injury, skeletal muscles in old mice regenerate less well than muscles in young mice. Extensor digitorum longus (EDL) muscles in young and old mice were exposed to 15 min of lengthening contractions. The amount of injury was evaluated at 3, 7, 14, 28, and 60 days by measurements of maximum isometric tetanic force (Po) and number of fibers per cross section. When values 3 days after lengthening contractions were expressed as a percentage of control values, the Po (approximately 34%) and fiber number (approximately 80%) f

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Guo, Zhenhong, and Jack Strominger. "Malfunction of dendritic cells from aged mice leads to loss of activation of Natural Killer cells (P4353)." Journal of Immunology 190, no. 1_Supplement (2013): 183.12. http://dx.doi.org/10.4049/jimmunol.190.supp.183.12.

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Abstract The interaction between dendritic cells (DC ) and Natural killer cells (NK) plays a key role in infectious disease and tumor immunology. However, the effect of aging on the crosstalk of DC and NK, a critical step in immune activation, has never been elucidated. In our study, we purified splenic DC and NK from young and old C57BL/6 mice and cocultured them in the presence of Poly I:C. Then the activation of NK cells including the expression of CD69 and IFN-gamma secretion was analyzed. The results showed that DC from old mice could not activate NK cells from either young or old mice; i

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Shi, Xingming, Kehong Ding, Yun Su та Carlos Isales. "Effect of PPARγ Inhibition on Bone in Aged Animals". Innovation in Aging 4, Supplement_1 (2020): 124. http://dx.doi.org/10.1093/geroni/igaa057.408.

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Abstract Aging is accompanied by bone loss and marrowfat accumulation. PPARg is a key factor regulating adipocyte differentiation. Marrowfat secretes large quantities of factors including adipokines, cytokines and chemokines that contribute to bone loss. We hypothesized that inhibition of PPARg would reduce adipocytes and adipose-generated inflammatory factors, and thus decrease aging-induced bone loss. To test this hypothesis, we treated young (6mo) and old (23mo) female C57BL/6 mice with a PPARg antagonist GW9662 (1mg/kg body weight, IP injection for 6wks) and examined the effects on bone, i

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Witte, Pamela, Erika Bahamon, and Shirin Birjandi. "Evidence for renewal and reconstitution of splenic marginal zone macrophages in young and aged mice (P4181)." Journal of Immunology 190, no. 1_Supplement (2013): 112.24. http://dx.doi.org/10.4049/jimmunol.190.supp.112.24.

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Abstract Previously, we showed that the spleens of old mice have reduced frequency of MZM and less ability to clear blood-borne particles. One reason for the demise of MZM with age may be lack of renewal, but little is known about turnover of MZM. Here, turnover of MZM was assessed after giving BrdU (injection or in drinking water). Double staining for MARCO and BrdU in spleens from young mice showed that MZM were turning over, either proliferating in situ or derived from dividing precursors. Next, flow cytometry was used to compare the frequencies of BrdU+ MZM per total MZM, from young and ol

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Zhang, Cangang, Lei Lei, Xiaofeng Yang, et al. "Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice." Journal for ImmunoTherapy of Cancer 9, no. 10 (2021): e002809. http://dx.doi.org/10.1136/jitc-2021-002809.

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BackgroundAging has long been thought to be a major risk factor for various types of cancers. However, accumulating evidence indicates increased resistance of old animals to tumor growth. An in-depth understanding of how old individuals defend against tumor invasion requires further investigations.MethodsWe revealed age-associated alterations in tumor-infiltrating immune cells between young and old mice using single-cell RNA and coupled T cell receptor (TCR) sequencing analysis. Multiple bioinformatics methods were adopted to analyze the characteristics of the transcriptome between two groups.

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Hagopian, Kevork, Jon J. Ramsey, and Richard Weindruch. "Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities." Bioscience Reports 28, no. 2 (2008): 107–15. http://dx.doi.org/10.1042/bsr20080015.

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The influence of caloric restriction on hepatic glyceraldehyde- and glycerol-metabolizing enzyme activities of young and old mice were studied. Glycerol kinase and cytoplasmic glycerol-3-phosphate dehydrogenase activities were increased in both young and old CR (calorie-restricted) mice when compared with controls, whereas triokinase increased only in old CR mice. Aldehyde dehydrogenase and aldehyde reductase activities in both young and old CR mice were unchanged by caloric restriction. Mitochondrial glycerol-3-phosphate dehydrogenase showed a trend towards an increased activity in old CR mic

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Boggia, Raffaella, Federica Turrini, Alessandra Roggeri, et al. "Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion." International Journal of Molecular Sciences 21, no. 10 (2020): 3631. http://dx.doi.org/10.3390/ijms21103631.

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The immune system and the central nervous system message each other to preserving central homeostasis. Both systems undergo changes during aging that determine central age-related defects. Ellagic acid (EA) is a natural product which is beneficial in both peripheral and central diseases, including aging. We analyzed the impact of the oral administration of a new oral ellagic acid micro-dispersion (EAm), that largely increased the EA solubility, in young and old mice. Oral EAm did not modify animal weight and behavioral skills in young and old mice, but significantly recovered changes in “ex-vi

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Kundu, Parag, Hae Ung Lee, Isabel Garcia-Perez, et al. "Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice." Science Translational Medicine 11, no. 518 (2019): eaau4760. http://dx.doi.org/10.1126/scitranslmed.aau4760.

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The gut microbiota evolves as the host ages, yet the effects of these microbial changes on host physiology and energy homeostasis are poorly understood. To investigate these potential effects, we transplanted the gut microbiota of old or young mice into young germ-free recipient mice. Both groups showed similar weight gain and skeletal muscle mass, but germ-free mice receiving a gut microbiota transplant from old donor mice unexpectedly showed increased neurogenesis in the hippocampus of the brain and increased intestinal growth. Metagenomic analysis revealed age-sensitive enrichment in butyra

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Thadepalli, H., S. K. Chuah, U. Reddy, et al. "Efficacy of trovafloxacin for treatment of experimental Bacteroides infection in young and senescent mice." Antimicrobial Agents and Chemotherapy 41, no. 9 (1997): 1933–36. http://dx.doi.org/10.1128/aac.41.9.1933.

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We investigated the efficacy of trovafloxacin, a new quinolone, in comparison with that of clindamycin in the treatment of intra-abdominal abscesses caused by Bacteroides fragilis in young and senescent mice. The development of abscess formation, the number of viable organisms, and antibiotic concentrations were measured, and the values for young and old mice were compared. Trovafloxacin was well distributed to the tissues in both young and old animals. Although the pharmacokinetics and concentrations of trovafloxacin in serum were similar between young and old mice, the levels in tissue were

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Gao, Teng, Yue Liu, Zifang Zhao, et al. "L-655,708 does not prevent isoflurane-induced memory deficits in old mice." Translational Neuroscience 10, no. 1 (2019): 180–86. http://dx.doi.org/10.1515/tnsci-2019-0032.

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Abstract Background General anesthesia and increasing age are two main risk factors for postoperative cognitive dysfunction (POCD). Effective agents for the prevention or treatment of POCD are urgently needed. L-655,708, an inverse agonist of α5 subunit-containing γ-aminobutyric acid subtype A (α5GABAA) receptors, can prevent anesthesia-induced memory deficits in young animals. However, there is a lack of evidence of its efficacy in old animals. Methodology Young (3- to 5-month-old) and old (18- to 20-month-old) mice were given an inhalation of 1.33% isoflurane for 1 hour and their associative

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Sung, Ji, Ji Kim, Jun Go, et al. "Age-related response of IL-4/Luc/CNS-1 transgenic miceto phthalic anhydrideexposure." Archives of Biological Sciences 68, no. 1 (2016): 145–54. http://dx.doi.org/10.2298/abs150417136s.

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Age-related changes are associated with susceptibility to infection, malignancy, autoimmunity, response to vaccination and wound healing. To investigate the relationship of several pathological phenotypes of allergic inflammationto age, alterations in theIL-4 derived luciferase signal and general phenotype biomarkers were measured in young (2-month-old) and old (12-month-old) IL-4/Luc/CNS-1 transgenic (Tg) mice with phthalic anhydride (PA)-induced allergic inflammationfor 2 weeks. There was no difference in the ear phenotypes and thickness between young and old mice, although these levels were

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Ferrer-Perez, Alba, Rebecca Andersson, Polina Zjablovskaja, et al. "Dissecting the Interactions between Leukemic Cells and the Aging Bone Marrow Niche." Blood 144, Supplement 1 (2024): 4070. https://doi.org/10.1182/blood-2024-206739.

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AML is a hematological disorder with a median age at onset of 70 years. TP53 mutations are observed in 5-10% of young adult AML cases, while TP53 mutation frequency increases significantly to more than 30% in older patients. Mutations result in inhibition of p53 function and are a strong predictor of inferior response to induction chemotherapy. Leukemic Stem Cells (LSCs) drive AML escape to chemotherapy and present with similar properties to normal adult hematopoietic stem cells (HSCs) depending on the bone marrow (BM) niche for proliferation and treatment survival. However, how TP53 LSCs inte

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Favre, Julie, Emilie Vessieres, Anne-Laure Guihot та ін. "Early Inactivation of Membrane Estrogen Receptor Alpha (ERα) Recapitulates the Endothelial Dysfunction of Aged Mouse Resistance Arteries". International Journal of Molecular Sciences 23, № 5 (2022): 2862. http://dx.doi.org/10.3390/ijms23052862.

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Flow-mediated dilation (FMD) of resistance arteries is essential for tissue perfusion but it decreases with ageing. As estrogen receptor alpha (Erα encoded by Esr1), and more precisely membrane ERα, plays an important role in FMD in young mice in a ligand-independent fashion, we evaluated its influence on this arteriolar function in ageing. We first confirmed that in young (6-month-old) mice, FMD of mesenteric resistance arteries was reduced in Esr1−/− (lacking ERα) and C451A-ERα (lacking membrane ERα). In old (24-month-old) mice, FMD was reduced in WT mice compared to young mice, whereas it w

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Hausman, P. B., E. A. Goidl, G. W. Siskind, and M. E. Weksler. "Immunological studies of aging. XI. Age-related changes in idiotype repertoire of suppressor T cells stimulated during tolerance induction." Journal of Immunology 134, no. 6 (1985): 3802–7. http://dx.doi.org/10.4049/jimmunol.134.6.3802.

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Abstract Tolerance was induced in young and old mice by the i.v. injection of TNP-modified syngeneic spleen cells. The tolerant state was associated with the development of hapten-specific suppressor T cells. The specificity of suppressor T cells was studied by transferring T cells from tolerant donors to normal, nonirradiated, syngeneic recipients, which were then immunized with TNP-Ficoll or TNP-bovine gamma-globulin. Suppressor T cells induced in young mice depressed the plaque-forming cell response of young but not old mice to both antigens. Similarly, suppressor T cells induced in old mic

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Lafuse, William P., Shrayes Sunkum, Naresh Kumar, Omar Santiagonunez Ahumada, Joanne Turner, and Murugesan V. S. Rajaram. "Psychological Stress of aged mice has long-term impact on Mycobacterium tuberculosis infection by altering composition of lung T cell populations." Journal of Immunology 208, no. 1_Supplement (2022): 50.14. http://dx.doi.org/10.4049/jimmunol.208.supp.50.14.

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Abstract Aging is a major risk factor for chronic infections, including tuberculosis (TB). Elderly TB patients also suffer from elevated levels of psychological stress. It is not known how psychological stress impacts TB pathogenesis. To study the effects of stress on Mycobacterium tuberculosis (M.tb) we used a social disruption stress (SDR) model which involves repeated social defeat in subordinate mice. Young (3 month) and Old (18 month) C57BL/6 mice were subjected to SDR and infected with M.tb. Mice were sacrificed at 30 and 60 days post infection and M.tb burden analyzed by CFU assay and l

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Aguilar, Carlos A. "Running makes old stem cells act young." Science Translational Medicine 12, no. 542 (2020): eabb7092. http://dx.doi.org/10.1126/scitranslmed.abb7092.

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Heydrick, S. J., N. Gautier, C. Olichon-Berthe, E. Van Obberghen, and Y. Le Marchand-Brustel. "Early alteration of insulin stimulation of PI 3-kinase in muscle and adipocyte from gold thioglucose obese mice." American Journal of Physiology-Endocrinology and Metabolism 268, no. 4 (1995): E604—E612. http://dx.doi.org/10.1152/ajpendo.1995.268.4.e604.

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The activation of phosphatidylinositol 3-kinase (PIK) was studied in vivo and in vitro in soleus muscle and adipocytes from young (8 wk) and old (30 wk) gold thioglucose obese mice. Insulin resistance assessed from muscle glucose transport and glycogen synthesis was present both in young and old obese mice. Adipocyte lipid synthesis and muscle glycolysis or glucose oxidation are not defective in young obese mice but become resistant later on. After incubation with 50 nM insulin, muscle antiphosphotyrosine-immunoprecipitable PIK activity was stimulated 5- to 10-fold in both young and old animal

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Reddy, A. K., D. Amador-Noguez, G. J. Darlington, et al. "Cardiac Function in Young and Old Little Mice." Journals of Gerontology Series A: Biological Sciences and Medical Sciences 62, no. 12 (2007): 1319–25. http://dx.doi.org/10.1093/gerona/62.12.1319.

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Osborne, Tamsin. "How old mice kept their livers forever young." New Scientist 199, no. 2669 (2008): 9. http://dx.doi.org/10.1016/s0262-4079(08)62029-1.

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Schofield, R., T. M. Dexter, B. I. Lord, and N. G. Testa. "Comparison of haemopoiesis in young and old mice." Mechanisms of Ageing and Development 34, no. 1 (1986): 1–12. http://dx.doi.org/10.1016/0047-6374(86)90100-4.

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VAN ZANT, JEFFREY L., and MICHAEL C. WOOTEN. "Old mice, young islands and competing biogeographical hypotheses." Molecular Ecology 16, no. 23 (2007): 5070–83. http://dx.doi.org/10.1111/j.1365-294x.2007.03582.x.

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Kanazawa, Yuji, Tatsuo Takahashi, Takao Inoue, et al. "Effects of Aging on Intramuscular Collagen-Related Factors After Injury to Mouse Tibialis Anterior Muscle." International Journal of Molecular Sciences 26, no. 2 (2025): 801. https://doi.org/10.3390/ijms26020801.

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Collagen I is the most abundant type of intramuscular collagen. Lysyl oxidase promotes collagen cross-link formation, which helps stabilize the extracellular matrix. Furthermore, matrix metalloproteinases, responsible for collagen degradation, maintain typical muscle structure and function through remodeling. Although it is well known that aging leads to delayed recovery of muscle fibers, the impact of aging on the remodeling of intramuscular collagen is not well understood. In this study, we investigated the impact of aging on collagen remodeling during muscle injury recovery using young and

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Zerba, E., T. E. Komorowski, and J. A. Faulkner. "Free radical injury to skeletal muscles of young, adult, and old mice." American Journal of Physiology-Cell Physiology 258, no. 3 (1990): C429—C435. http://dx.doi.org/10.1152/ajpcell.1990.258.3.c429.

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We tested the hypotheses that 1) muscles of old mice are more susceptible to injury than muscles of young and adult mice, and 2) secondary or delayed onset injury results from free radical damage. Extensor digitorum longus muscles were injured in situ by lengthening contractions. Injury was assessed by measurement of maximum isometric tetanic force (Po) expressed as a percentage of the control value and by morphological damage. Mice were treated with a free radical scavenger, polyethylene glycol-superoxide dismutase (PEG-SOD). Three days postinjury, the Po of 44% for muscles of nontreated old

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Lin, Ligen, Jong Lee, Ruitao Wang, et al. "aP2-Cre Mediated Ablation of GHS-R Attenuates Adiposity and Improves Insulin Sensitivity during Aging." International Journal of Molecular Sciences 19, no. 10 (2018): 3002. http://dx.doi.org/10.3390/ijms19103002.

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Ghrelin via its receptor, the growth hormone secretagogue receptor (GHS-R), increases food intake and adiposity. The tissue-specific functions of GHS-R in peripheral tissues are mostly unknown. We previously reported that while GHS-R expression is very low in white and brown fat of young mice, expression increases during aging. To investigate whether GHS-R has cell-autonomous effects in adipose tissues, we generated aP2-Cre-mediated GHS-R knockdown mice (aP2-Cre/Ghsrf/f). We studied young (5–6 months) and old (15–17 months) aP2-Cre/Ghsrf/f mice and their age-matched controls. Interestingly, yo

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Lu, Q., M. A. Ceddia, E. A. Price, S. M. Ye, and J. A. Woods. "Chronic exercise increases macrophage-mediated tumor cytolysis in young and old mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276, no. 2 (1999): R482—R489. http://dx.doi.org/10.1152/ajpregu.1999.276.2.r482.

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In this study, we determined the effects of age and chronic treadmill running (16 wk; 5 days/wk; 45 min/day; 18–22 m/min) on resident peritoneal macrophage responsiveness to interferon-γ (IFN-γ) and lipopolysaccharide (LPS) in young (6 mo) and aged (22 mo) male BALB/cByJ mice by measuring cytolytic ability and production of reactive nitrogen products. Macrophages (>90% Mac-3+) were incubated with various concentrations of IFN-γ and LPS for 24 h. After washing, P815 tumor cells were utilized as targets in a 16-h51Cr release assay. We found that aging resulted in a significant reduction in th

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Claudino, Mário Angelo, Luiz Osório Leiria, Carla Fernanda Franco-Penteado, et al. "Young and Old Sickle Cell Disease Transgenic Mice Present Underactive Bladder." Blood 122, no. 21 (2013): 2248. http://dx.doi.org/10.1182/blood.v122.21.2248.2248.

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Abstract Urinary bladder dysfunction is rarely spontaneously reported by sickle cell disease (SCD) patients to their caregivers. With increasing survival of these patients, physicians may expect that urinary complaints increase in association with classical urological disorders associated with advanced age. Nocturia has long been attributed to constant increased urinary volumes in SCD. As part of the renal complications of sickling, renal medullary infarcts lead to decreased ability to concentrate urine, yielding higher daily urinary volumes, compensatory polydipsia and, eventually, the need f

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Decman, Vilma, Brian Laidlaw, Hildegund Ertl, and E. John Wherry. "Memory T cells generated in youth function well in old age (49.8)." Journal of Immunology 186, no. 1_Supplement (2011): 49.8. http://dx.doi.org/10.4049/jimmunol.186.supp.49.8.

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Abstract Aging-associated changes negatively influence T cell responses. Since we previously observed that the memory CD8 T cells generated in aged mice have substantially reduced proliferative expansion upon secondary infection, we wanted to investigate if observed defects of memory T cells are due to the age of the cell or the age of the host when primed. Briefly, virus-specific memory T cells were generated by infecting young mice, aged mice or by infecting mice when they were young, but then allowing these mice to age for 2 years. T cells from these three groups were adoptively transferred

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Yazicioglu, Tolga, Christian Mühlfeld, Chiara Autilio, et al. "Aging impairs alveolar epithelial type II cell function in acute lung injury." American Journal of Physiology-Lung Cellular and Molecular Physiology 319, no. 5 (2020): L755—L769. http://dx.doi.org/10.1152/ajplung.00093.2020.

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Morbidity and mortality rates in acute lung injury (ALI) increase with age. As alveolar epithelial type II cells (AE2) are crucial for lung function and repair, we hypothesized that aging promotes senescence in AE2 and contributes to the severity and impaired regeneration in ALI. ALI was induced with 2.5 μg lipopolysaccharide/g body weight in young (3 mo) and old (18 mo) mice that were euthanized 24 h, 72 h, and 10 days later. Lung function, pulmonary surfactant activity, stereology, cell senescence, and single-cell RNA sequencing analyses were performed to investigate AE2 function in aging an

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Lafuse, William P., Qian Wu, Noushin Saljoughian, Joanne Turner, and Murugesan Rajaram. "Psychological stress creates an immune-suppressive environment that increases the susceptibility of aged mice to Mycobacterium tuberculosis infection." Journal of Immunology 204, no. 1_Supplement (2020): 67.16. http://dx.doi.org/10.4049/jimmunol.204.supp.67.16.

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Abstract Age is a risk factor for chronic infections, including tuberculosis (TB). A second compounding factor of TB susceptibility is psychological stress, which is particularly acute in older individuals. While the influence of psychological stress in TB is well documented, the mechanisms by which stress influences M.tb susceptibility in the elderly are almost completely unknown. To study the effects of chronic psychological stress on M.tb infection in old mice, we employed a mouse social stressor model (called social disruption stress or SDR) which involves repeated social defeat in subordi

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Badran, Mohammad, Clementine Puech, Abdelnaby Khalyfa, and David Gozal. "0281 Mortality and Cardiovascular Changes in a Murine Model of OSA: Aging and 22 Months of Intermittent Hypoxia." SLEEP 47, Supplement_1 (2024): A121. http://dx.doi.org/10.1093/sleep/zsae067.0281.

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Abstract Introduction Obstructive sleep apnea (OSA) is a prevalent condition marked by intermittent hypoxia (IH), which significantly elevates the risk of cardiovascular disease (CVD) and overall mortality. Furthermore, aging is a widely acknowledged risk factor for the onset and progression of CVD. In this pioneering study, we aim to elucidate the interplay between 22 months of IH exposures and age-related factors by delineating their combined influence on a spectrum of cardiovascular parameters. Methods Male C57Bl/6J mice (n=19-23) were exposed to IH (cycles of FiO2 21% 90 s-6% 90s or room a

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Ma, Yonggang, Ying Ann Chiao, Jianhua Zhang, Anne M. Manicone, Yu-Fang Jin, and Merry L. Lindsey. "Matrix Metalloproteinase-28 Deletion Amplifies Inflammatory and Extracellular Matrix Responses to Cardiac Aging." Microscopy and Microanalysis 18, no. 1 (2011): 81–90. http://dx.doi.org/10.1017/s1431927611012220.

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AbstractTo determine if matrix metalloproteinase (MMP)-28 mediates cardiac aging, wild-type (WT) and MMP-28−/− young (7 ± 1 months, n = 9 each) and old (20 ± 2 months, n = 7 each) female mice were evaluated. MMP-28 expression in the left ventricle (LV) increased 42% in old WT mice compared to young controls (p < 0.05). By Doppler echocardiography, LV function declined at 20 ± 2 months of age for both groups. However, dobutamine stress responses were similar, indicating that cardiac reserve was maintained. Plasma proteomic profiling revealed that macrophage inflammatory protein (MIP)-1 α, MI

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Ikeda, Kazuhiko, Philip J. Mason, Kayo Shirado Harada, Kazuei Ogawa, Monica Bessler, and Yasuchika Takeishi. "Ineffective Erythropoiesis With Increased Neutrophils In Old Mice Overexpressing Hmga2 cDNA." Blood 122, no. 21 (2013): 2469. http://dx.doi.org/10.1182/blood.v122.21.2469.2469.

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Abstract HMGA2 is frequently overexpressed in hematopoietic cells of patients with paroxysmal nocturnal hemoglobinuria (PNH) and primary myelofibrosis (PMF), and occasionally in myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN). We recently reported that transgenic mice overexpressing truncated Hmga2 cDNA (ΔHmga2 mice) showed increased numbers in all lineages of peripheral blood (PB) cells, hypercellular bone marrow (BM), and splenomegaly in young adults of 3 months old (Ikeda et al, Blood, 2011). ΔHmga2 mice also showed growth advantage of hematopoietic stem cells (HSCs) in ser

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Kraimi, N., G. De Palma, J. Lu, et al. "A14 THE INTESTINAL MICROBIOTA CONTRIBUTES TO AGE-RELATED MEMORY DECLINE." Journal of the Canadian Association of Gastroenterology 5, Supplement_1 (2022): 17–18. http://dx.doi.org/10.1093/jcag/gwab049.013.

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Abstract Background Age-related deterioration of cognitive function and memory capacity occur in both humans and rodents. For example, significant memory deficits have been reported in conventionally raised (SPF) old mice compared to conventionally raised young mice submitted to a spatial memory task (Prevot et al., 2019, Mol Neuropsychiatry 5, 84–97). Microbiota-to-brain signaling is now well established in mice and humans, but the extent to which it influences age-associated memory decline is unknown. Aims Our study examines whether the intestinal microbiota contributes to age-associated cha

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Kanazawa, Yuji, Yuri Ikeda-Matsuo, Hiaki Sato, et al. "Effects of Obesity in Old Age on the Basement Membrane of Skeletal Muscle in Mice." International Journal of Molecular Sciences 24, no. 11 (2023): 9209. http://dx.doi.org/10.3390/ijms24119209.

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Obesity and aging are known to affect the skeletal muscles. Obesity in old age may result in a poor basement membrane (BM) construction response, which serves to protect the skeletal muscle, thus making the skeletal muscle more vulnerable. In this study, older and young male C57BL/6J mice were divided into two groups, each fed a high-fat or regular diet for eight weeks. A high-fat diet decreased the relative gastrocnemius muscle weight in both age groups, and obesity and aging individually result in a decline in muscle function. Immunoreactivity of collagen IV, the main component of BM, BM wid

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Lambert, Nathaniel D., Deanna M. Langfitt, Matthew L. Nilles, and David S. Bradley. "Resistance to Yersinia pestis Infection Decreases with Age in B10.T(6R) Mice." Infection and Immunity 79, no. 11 (2011): 4438–46. http://dx.doi.org/10.1128/iai.05267-11.

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ABSTRACTWe demonstrate that 2-month-old female B10.T(6R) mice are highly resistant to systemic infection with the KIM5 strain ofYersinia pestisand that B10.T(6R) mice become susceptible toY. pestisinfection by the age of 5 months. In this study, young (2-month-old) and middle-aged (5- to 12-month-old) B10.T(6R) mice were infected with equal CFU counts ofY. pestis. The 50% lethal dose (LD50) for young B10.T(6R) mice was ∼1.4 × 104CFU, while middle-aged B10.T(6R) mice exhibited an LD50of ∼60 CFU. Elevated bacterial burdens were found in the spleens of middle-aged mice at 24 and 60 h and in the l

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Wen, Sicheng, Jill Kreiling, Mark S. Dooner, et al. "Age-Associated Changes in Bone Marrow-Derived Extracellular Vesicles May Alter Their Effects on Murine Hematopoietic Stem Cell Function." Blood 136, Supplement 1 (2020): 37. http://dx.doi.org/10.1182/blood-2020-142444.

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Extracellular vesicles (EVs) are critical mediators of intercellular communication within the bone marrow niche and have been implicated in numerous features of aging. However, their role in natural hematopoietic stem cell (HSC) aging has not been fully elucidated. The goal of this work was to test the hypothesis that EVs from whole bone marrow (BM-EVs) can modulate the HSC aging phenotype in vivo. With respect to HSC aging, our prior work showed that, in contrast to the well-known reduced functional capacity and prominent myeloid skewing displayed by old immunophenotypically-defined HSCs, old

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Naddaf, Lamis, Marco De Dominici, Xiaowen Chen, et al. "Title: In Vivo Clonal Tracing of Hematopoietic Stem and Progenitor Cells Reveals Increased Clonal Heterogeneity during Aging, Alongside Critical Changes in Selection Patterns." Blood 144, Supplement 1 (2024): 2671. https://doi.org/10.1182/blood-2024-202289.

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Aging impacts the bone marrow microenvironment by inducing inflammation. We hypothesize that aging increases heritable epigenetic heterogeneity, leading to transcriptome heterogeneity within hematopoietic stem and progenitor cells (HSPC). This resulting heterogenous state, combined with the aged microenvironment-driven selection, shifts the functional capacity of the hematopoietic system, contributing to the functional decline of the hematopoietic system as well as the evolution of diseases such as myelodysplastic syndrome and leukemias. Our research aims to investigate clonal heterogeneity in

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Ren, Zhihong, Raina Gay, Adam Thomas, et al. "Effect of age on susceptibility to Salmonella Typhimurium infection in C57BL/6 mice." Journal of Medical Microbiology 58, no. 12 (2009): 1559–67. http://dx.doi.org/10.1099/jmm.0.013250-0.

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Ageing is associated with a decline in immune function, which predisposes the elderly to a higher incidence of infections. Information on the mechanism of the age-related increase in susceptibility to Salmonella enterica serovar Typhimurium (S. Typhimurium) is limited. In particular, little is known regarding the involvement of the immune response in this age-related change. We employed streptomycin (Sm)-pretreated C57BL/6 mice to develop a mouse model that would demonstrate age-related differences in susceptibility and immune response to S. Typhimurium. In this model, old mice inoculated oral

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Doria, G., C. Mancini, D. Frasca, and L. Adorini. "Age restriction in antigen-specific immunosuppression." Journal of Immunology 139, no. 5 (1987): 1419–25. http://dx.doi.org/10.4049/jimmunol.139.5.1419.

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Abstract Age-related alterations of antigen-specific T cell-mediated suppression have been examined in the 4-hydroxy-3-nitrophenyl acetyl (NP) system. Inducer suppressor T cells (Tsi) were activated in mice at the age of 3 mo (young) or 18 mo (old) by i.v. injection of NP-conjugated syngeneic spleen cells (SC). Spleen cells from the NP-SC-injected mice were subcultured in vitro with spleen cells from normal young or old mice to generate transducer suppressor T cells (Tst). Four days later subcultured cells were added to responder cell cultures 1 day before the PFC assays to trigger effector su

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Rosa, Frederico Luis Lima, Itanna Isis Araujo de Souza, Gustavo Monnerat, Antonio Carlos Campos de Carvalho, and Leonardo Maciel. "Aging Triggers Mitochondrial Dysfunction in Mice." International Journal of Molecular Sciences 24, no. 13 (2023): 10591. http://dx.doi.org/10.3390/ijms241310591.

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Direct analysis of isolated mitochondria from old mice enables a better understanding of heart senescence dysfunction. Despite a well-defined senescent phenotype in cardiomyocytes, the mitochondrial state in aged cardiomyocytes is still unclear. Here, we report data about mitochondrial function in old mice. Isolated cardiomyocytes’ mitochondria were obtained by differential centrifugation from old and young mice hearts to perform functional analyses of mitochondrial O2 consumption, transmembrane potential, ROS formation, ATP production, and swelling. Our results show that mitochondria from old

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