Relevant bibliographies by topics / Yue du jiao xue

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  2. Dissertations / Theses
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  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Yue du jiao xue'

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Published: 4 June 2021
Last updated: 29 July 2024

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Journal articles on the topic "Yue du jiao xue"

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Gao, Yue, Chun-Jie Liu, Hua-Yi Li, Xiao-Ming Xiong, Sjors G. j. g. In ‘t Veld, Gui-Ling Li, Jia-Hao Liu, et al. "Abstract LB168: Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study." Cancer Research 82, no. 12_Supplement (June 15, 2022): LB168. http://dx.doi.org/10.1158/1538-7445.am2022-lb168.

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Abstract Background: Morpho-physiological alternations of platelets provided a rationale to harness RNA sequencing of tumor-educated platelets (TEPs) for preoperative diagnosis of cancer. Timely, accurate, and non-invasive detection of ovarian cancer in women with adnexal masses presents a significant clinical challenge. Patients and Methods: This intercontinental, hospital-based, diagnostic study included 761 treatment-naïve inpatients with histologically confirmed adnexal masses and 167 healthy controls from nine medical centers (China, n=3; Netherlands, n=5; Poland, n=1) between September 2016 and May 2019. The main outcomes were the performance of TEPs and their combination with CA125 in two Chinese (VC1 and VC2) and the European (VC3) validation cohorts collectively and independently. Exploratory outcome was the value of TEPs in public pan-cancer platelet transcriptome datasets. Results: The AUCs for TEPs in the combined validation cohort, VC1, VC2, and VC3 were 0.918 (95% CI 0.889-0.948), 0.923 (0.855-0.990), 0.918 (0.872-0.963), and 0.887 (0.813-0.960), respectively. Combination of TEPs and CA125 demonstrated an AUC of 0.922 (0.889-0.955) in the combined validation cohort; 0.955 (0.912-0.997) in VC1; 0.939 (0.901-0.977) in VC2; 0.917 (0.824-1.000) in VC3. For subgroup analysis, TEPs exhibited an AUC of 0.858, 0.859, and 0.920 to detect early-stage, borderline, non-epithelial diseases and 0.899 to discriminate ovarian cancer from endometriosis. Analysis of public datasets suggested that TEPs had potential to detect multiple malignancies (Table 1). Conclusions: TEPs had robustness, compatibility, and universality for preoperative diagnosis of ovarian cancer since it withstood validations in populations of different ethnicities, heterogeneous histological subtypes, early-stage ovarian cancer as well as other malignancies. However, these observations warrant prospective validations in a larger population before clinical utilities. Table 1. Performance for TEPs in public pan-cancer datasets. Disease n Healthy Control AUC, area under the curve (95% CI) Women NSCLC (non-small-cell lung cancer) 126 77 0.758 (0.691-0.825) Breast cancer 38 77 0.817 (0.726-0.909) Colorectal cancer 18 77 0.973 (0.945-1.000) Pancreatic cancer 16 77 0.993 (0.981-1.000) Glioblastoma 10 77 0.923 (0.831-1.000) Men NSCLC 119 82 0.746 (0.677-0.815) Colorectal cancer 25 82 0.933 (0.884-0.982) Pancreatic cancer 22 82 0.993 (0.984-1.000) Glioblastoma 19 82 0.981 (0.959-1.000) All NSCLC 245 159 0.774 (0.728-0.820) Colorectal cancer 40 159 0.978 (0.961-0.996) Breast cancer 38 159 0.821 (0.736-0.906) Pancreatic cancer 35 159 0.987 (0.974-0.999) Glioblastoma 35 159 0.931 (0.890-0.972) Hepatobiliary carcinomas 14 159 0.991 (0.978-1.000) Citation Format: Yue Gao, Chun-Jie Liu, Hua-Yi Li, Xiao-Ming Xiong, Sjors G.j.g. In ‘t Veld, Gui-Ling Li, Jia-Hao Liu, Guang-Yao Cai, Gui-Yan Xie, Shao-Qing Zeng, Yuan Wu, Jian-Hua Chi, Qiong Zhang, Xiao-Fei Jiao, Lin-Li Shi, Wan-Rong Lu, Wei-Guo Lv, Xing-Sheng Yang, Jurgen M.j. Piek, Cornelis D de Kroon, C.a.r. Lok, Anna Supernat, Sylwia Łapińska-Szumczyk, Anna Łojkowska, Anna J. Żaczek, Jacek Jassem, Bakhos A. Tannous, Nik Sol, Edward Post, Myron G. Best, Bei-Hua Kong, Xing Xie, Ding Ma, Thomas Wurdinger, An-Yuan Guo, Qing-Lei Gao. Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB168.
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Wang, Xue, Feng Du, Jian Yue, Yiran Si, Lina Cui, Bei Zhang, Xiaochen Zhao, Binghe Xu, and Peng Yuan. "Abstract 5084: KMT2D and PIK3CA mutation as potential factors to predict adjuvant chemotherapy efficacy in surgical triple negative breast cancer." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5084. http://dx.doi.org/10.1158/1538-7445.am2022-5084.

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Abstract Background: Chemotherapy is the most common treatment strategy for triple negative breast cancer (TNBC) patients. Nevertheless, due to adverse drug reactionsthe molecular high heterogeneity of TNBC and no appropriate meaningful efficacy markers, it is still difficult to establish preferred therapeutic strategies and predict the outcomes for TNBC. This study was to investigate the potential predictors and therapeutic targets based on genetic features. Methods: A total of 386 TNBC patients were randomized 1:1 to receive either six cycles of paclitaxel + cisplatin (TP) or four cycles of epirubicin + cyclophosphamide followed by four cycles of docetaxel (EC-T) adjuvant chemotherapy after surgery (NCT01150513), which were described previously. Finally, 149 TNBC patients with clinical and tumor sequencing data availability were retrospectively analysed by NGS for 733 cancer-related genes. All tumor samples were collected during the surgical operation and subjected to NGS for evaluating genomic mutations and the potential predictors. Cox regression model and Kaplan-Meier method were applied to evaluate disease-free survival (DFS). Results: In the surgical cohort receiving adjuvant chemotherapy, 74 patients received platinum and 75 received platinum-free chemotherapy as adjuvant chemotherapy. The most frequently mutated genes in this surgical TNBC cohort were TP53 (84%), BRCA1 (18%), BRCA2 (15%), POL1 (13%), PTEN (12%), REV3L (11%), FANCC (10%), and PARP4 (10%). We analyzed the associations between 733 cancer-related gene mutations and DFS after adjuvant chemotherapy. For the TP group, PIK3CA mutation (19%, 14/74) was discovered to correlate with poor DFS for patients treated with platinum-containing adjuvant therapy (HR=3.2, P=0.037), and KMT2D mutation (15%, 11/75) display worse DFS for patients treated with EC-T platinum-free group (HR=3.0, p=0.039). However, BRCA1/2 mutation (24%, 35/149) was found to be associated with poor prognosis (HR=2.1 (95% CI: 1-4.6), p=0.047), irrespective of therapeutic regimen. Conclusions: In this population of surgical TNBC patients, NGS analysis identified potential predictive markers. PIK3CA mutation in TP platinum-containing group and KMT2D mutation in EC-T platinum-free group were significantly associated to poor prognosis for adjuvant chemotherapy in triple negative breast cancer. Citation Format: Xue Wang, Feng Du, Jian Yue, Yiran Si, Lina Cui, Bei Zhang, Xiaochen Zhao, Binghe Xu, Peng Yuan. KMT2D and PIK3CA mutation as potential factors to predict adjuvant chemotherapy efficacy in surgical triple negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5084.
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Yue, Jian, Xue Wang, Jie Ju, Zixiang Yang, Tong Wei, Peng Yuan, Min Gao, Ling Xu, and Yin Guan. "Abstract PO4-05-04: Comparative effectiveness of Palbociclib plus Aromatase inhibitor versus fulvestrant alone as initial endocrine therapy for HR+/HER2- advanced breast cancer in Chinese clinical practice: a real-world study." Cancer Research 84, no. 9_Supplement (May 2, 2024): PO4–05–04—PO4–05–04. http://dx.doi.org/10.1158/1538-7445.sabcs23-po4-05-04.

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Abstract Background: In the real world, there are still a large number of HR+/HER2- advanced breast cancer patients receiving initial endocrine therapy with fulvestrant monotherapy in China, especially patients with bone metastases only. It is due to lack of data comparing the effective between Palbociclib combined with AI and fulvestrant monotherapy as initial endocrine therapy. On the other hand, there are economic factors and access issues. According to the National Cancer Center's previous clinical experience, Palbociclib combined with AI is superior to fulvestrant monotherapy in HR+/HER2- advanced breast cancer patients receiving initial endocrine therapy. Therefore, we collected and summarized the previous clinical data in our center to compare the effective of Palbociclib combined with AI and fulvestrant monotherapy for HR+/HER2-advanced breast cancer patients receiving initial endocrine therapy in China. Patients and methods: This is a retrospective real-world study of multicenter studies. It aimed at verifying the effective of Palbociclib combined with AI and fulvestrant monotherapy for HR+/HER2-advanced breast cancer patients receiving initial endocrine therapy in China. A total of 392 patients with ≥3 months of follow-up received Palbociclib plus AI or fulvestrant alone in the first-line setting between April 1, 2015 and February 1, 2023. Stabilized inverse probability treatment weighting (sIPTW) was used to balance baseline demographic and clinical characteristics. Real-world progression-free survival (rwPFS) and overall survival (OS) were analyzed. Results: After sIPTW adjustment, a median follow-up of 37 months (range 34-40) in the Palbociclib group and 59 months (range 56-61) in those taking fulvestrant alone. Palbociclib combination regiment was associated with significantly longer median rwPFS compared to fulvestrant alone (22.0 vs 14.0 months; HR,0.469;95% CI 0.370–0.594, p< 0·0001). Median OS was not reached in the Palbociclib group and was 57 months (95% CI 54.0–66.0) in the fulvestrant group(HR,0.666; 95% CI 0.437–1.017, p< 0·94). Conclusion: In the real-world population of patients, palbociclib combined with AI endocrine therapy is superior to fulvestrant monotherapy in HR+/HER2- advanced breast cancer patients receiving initial endocrine therapy. PFS and OS before IPTW PFS and OS after IPTW Table patient characteristics Citation Format: Jian Yue, Xue Wang, Jie Ju, Zixiang Yang, Tong Wei, Peng Yuan, Min Gao, Ling Xu, Yin Guan. Comparative effectiveness of Palbociclib plus Aromatase inhibitor versus fulvestrant alone as initial endocrine therapy for HR+/HER2- advanced breast cancer in Chinese clinical practice: a real-world study [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO4-05-04.
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Liu, Pinghua, and Na Liu. "The rites and music education in Zhu Zi's Xiao Xue." Advances in Education, Humanities and Social Science Research 2, no. 1 (September 20, 2022): 154. http://dx.doi.org/10.56028/aehssr.2.1.154.

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Chinese civilization has always been called "rites and music civilization"(li-yue-wen-ming ). It is also the due meaning of sacred education to educate the people and change customs with rites and music. Chinese sage education aims to cultivate benevolent gentlemen with five constant virtues, which are based on benevolence, and this benevolence is embodied in the civilization of rites and music in Chinese society. It is precisely because of "the substance and function relationship"(ti-yong-guan-xi ) between benevolence and "the system of rites and music"(li-yue-zhi-du ) that Zhu Zi's Xiao Xue education pays particular attention to cultivating gentlemen with ideal personality through rites and music education.
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Liu, Pinghua, and Na Liu. "The rites and music education in Zhu Zi's Xiao Xue." Advances in Education, Humanities and Social Science Research 1, no. 2 (September 20, 2022): 154. http://dx.doi.org/10.56028/aehssr.1.2.154.

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Chinese civilization has always been called "rites and music civilization"(li-yue-wen-ming ). It is also the due meaning of sacred education to educate the people and change customs with rites and music. Chinese sage education aims to cultivate benevolent gentlemen with five constant virtues, which are based on benevolence, and this benevolence is embodied in the civilization of rites and music in Chinese society. It is precisely because of "the substance and function relationship"(ti-yong-guan-xi ) between benevolence and "the system of rites and music"(li-yue-zhi-du ) that Zhu Zi's Xiao Xue education pays particular attention to cultivating gentlemen with ideal personality through rites and music education.
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Xue, Wei-Wei, Huan-Nan Wang, Zhi-Meng Wang, Meng-Xi Qiu, Jing Che, Feng-Jiao Deng, and Jiang-Dong Liu. "Cloning and Characterization of ifitm1 and ifitm3 Expression During Early Zebrafish Development - CORRIGENDUM." Zygote 24, no. 1 (July 21, 2015): 159. http://dx.doi.org/10.1017/s0967199415000398.

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The authors apologise for errors in the corresponding authors details given on page 1 of the article. Below is the correct information of the corresponding author and email address :1) Wei-Wei Xue, Huan-Nan Wang, Zhi-Meng Wang, Meng-Xi Qiu, Jing Che, Feng-Jiao Deng* and Jiang-Dong Liu*2) *All correspondence to: Feng-Jiao Deng and Jiang-Dong Liu. e-mail: fish4@whu.edu.cn3) All authors are from the same one laboratory. The second laboratory was superfluous and should be deleted.
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Wang, Xue, Jian Yue, Jiayu Wang, Pin Zhang, Fei Ma, Binghe Xu, and Peng Yuan. "Abstract P3-02-07: Combined Chemo-endocrine Therapy Maybe a New Option for HR+/HER2− Advanced Breast Cancer: A Prospective, Single-center Clinical Study of Fulvestrant plus Oral Vinorelbine." Cancer Research 83, no. 5_Supplement (March 1, 2023): P3–02–07—P3–02–07. http://dx.doi.org/10.1158/1538-7445.sabcs22-p3-02-07.

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Abstract Background Fulvestrant have demonstrated synergistic antitumor effect with chemotherapy regimen. This study evaluates the efficacy and safety of Fulvestrant with Vinorelbine in patients with hormone receptor positive (HR+)/human epidermal growth factor receptor-2-negative (HER2−) recurrent or metastatic breast cancer. Methods In this prospective, single-arm and investigator-initiated clinical study, patients with recurrent or metastatic HR+/HER2− breast cancer after the first line adjuvant endocrine therapy for > 1 year were eligible, in which the subjects of the first line was defined as the patients with recurrence and metastasis after adjuvant endocrine therapy for over 1 year and did not receive treatment for the recurrence and metastasis and the second-line defined as the patients who had disease progression after receiving first-line endocrine therapy or first-line chemotherapy). Patients were administered i.m. Fulvestrant 500mg (day 1 per cycle for 28 days) and oral Vinorelbine (60 mg/m2 on day 1, 8 and 15 of each cycle). The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), objective response rate (ORR), disease control rate (DCR), duration of response (DoR), and safety. The Kaplan–Meier method and log-rank test were used to evaluate PFS and OS. Results Total 38 HR+/HER2- advanced breast cancer patients with median follow-up time (25.1 months) were enrolled in, and median PFS [9.86 months (95% CI: 7.2, 23.13)] were discovered. The median PFS of the first-line and the second-line treatment population were 20.73 months (95% CI: 9.82, NR) and 4.27 months (95% CI: 3.68, NR), respectively. The median OS of the intent-to-treat (ITT) and the first-line treatment population were not reached, and the OS of the second-line treatment was 28.2 months (95% CI: 11.5, NR). The ORR of the ITT population was 39.47% (95% CI: 23.93, 55.01). The ORR of the patients receiving first-line and second-line treatments were 44.44% (95% CI: 25.70, 63.19) and 27.27% (95% CI: 0.95, 53.59), respectively. The DCR of ITT population was 92.11% (95% CI: 83.54, 100.00)], and the median DoR was approximately 15.33 months (95% CI: 7.23, 22.54)]. In the safety analysis, most of the adverse events were grade of 1/2, and none of grade 4/5 adverse events were reported. Conclusion This is the first exploratory study of Fulvestrant with oral Vinorelbine regimen in the treatment of HR+/HER2− recurrent and metastatic breast cancer conducted worldwide. The combinative chemo-endocrine therapy was efficacious, safe and promising for patients with HR+/HER2− advanced breast cancer. Citation Format: Xue Wang, Jian Yue, Jiayu Wang, Pin Zhang, Fei Ma, Binghe Xu, Peng Yuan. Combined Chemo-endocrine Therapy Maybe a New Option for HR+/HER2− Advanced Breast Cancer: A Prospective, Single-center Clinical Study of Fulvestrant plus Oral Vinorelbine [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P3-02-07.
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Wang, Xue, Yimeng Chen, Feng Du, Jian Yue, Yiran Si, Xiaochen Zhao, Lina Cui, et al. "Abstract 5689: Effects of homologous recombination-related gene mutation subtypes on gene instability and the efficacy of platinum-containing regiments in triple-negative breast cancer." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5689. http://dx.doi.org/10.1158/1538-7445.am2022-5689.

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Abstract Background: Platinum-containing chemotherapy is treatment with high efficacy in homologous recombination (HR) deficient cancers that arise in carriers of mutations in the BRCA1/2 genes. However, previous reports have shown that TNBC patients carrying no BRCA1/2 mutations also could benefit from platinum therapy. This study aimed to explore the association between HR-related gene mutations and genomic instability, and further evaluate the effectiveness of platinum-containing chemotherapy preliminarily. Methods: A total of 386 TNBC patients were screened from a surgical cohort (NCT01150513) and a metastatic cohort. Finally, 189 TNBC patients with clinical and tumor sequencing data availability were included, including 149 patients treated with radical surgery and adjuvant chemotherapy. All tumor samples were collected during the surgical operation and subjected to NGS for evaluating homologous recombination deficiency (HRD) score and 15 HR-related gene pathogenic or likely pathogenic mutations (including ATM, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK1, CHEK2, FANCL, PALB2, PPP2R2A, RAD51B, RAD51D, RAD51C, RAD54L). HRD score was an algorithmic assessment of three biomarkers of genomic instability as loss of heterozygosity, telomeric-allelic imbalance, large-scale state transitions and based on over 10,000 single-nucleotide polymorphisms in the human genome. Results: In 189 TNBC cohort, 40 patients (21.1%) had BRCA1/2 deleterious mutations, with additional 26 patients (13.8%) carrying mutations in HR-related genes other than BRCA1/2. Compared with BRCA1/2-intact patients, those carrying BRCA1/2m displayed a significantly higher HRD score (median, 35.5 vs 20.0; P=0.02). However, patients with HRm obtained a similar HRD score with HRwt patients (median, 28.0 vs 21.0, P=0.83). TNBC patients with PALB2m (n=8) had a small trend higher HRD score compared with BRCA1/2m (median HRD score 39.0 and 35.5), and TNBC patients with RAD51 family (n=7), ATM (n=5) and other HR-related gene mutations had a numerical trend lower HRD score compared with BRCA1/2m (median HRD score 22.0, 4.0, 14.5 and 35.5). Of the 149 patients in surgical cohort, 74 received platinum-containing, and 75 underwent platinum-free adjuvant chemotherapy. We analyzed the associations between HR-related gene mutations and disease-free survival (DFS), and found that patients with RAD51Bm (n=3), RAD51Cm (n=1) or PPP2R2Am (n=1) displayed worse DFS for patients treated with adjuvant chemotherapy (P =0.012, P<0.0001 or P<0.0001, respectively). Conclusions: In this study, we found that different HR-related genes mutation subtypes may exert distinct effects on genomic instability, and mutations in HR-related genes beyond the context of BRCA1/2 may serve as a biomarker for platinum-based adjuvant therapy for TNBC patients, which warrants further studies. Citation Format: Xue Wang, Yimeng Chen, Feng Du, Jian Yue, Yiran Si, Xiaochen Zhao, Lina Cui, Bei Zhang, Ting Bei, Peng Yuan, Binghe Xu. Effects of homologous recombination-related gene mutation subtypes on gene instability and the efficacy of platinum-containing regiments in triple-negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5689.
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LIU, Guoxuan. "A Complementary Research on Guang Jiao chou lue (《廣校 讎略》) and Jiao Chou Xue (《校讎學》)." Journal of Chinese Characters 16 (December 30, 2016): 139–49. http://dx.doi.org/10.14772/cscck.2016.16.139.

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Chen, Yimeng, Xue Wang, Feng Du, Jian Yue, Yiran Si, Lina Cui, Bei Zhang, Binghe Xu, and Peng Yuan. "Abstract P1-08-12: The status of homologous recombination deficiency is a potential biomarker for platinum-based chemotherapy in triple-negative breast cancer." Cancer Research 82, no. 4_Supplement (February 15, 2022): P1–08–12—P1–08–12. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-08-12.

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Abstract BackgroundTriple-negative breast cancer (TNBC) is a subtype of breast cancer that is highly susceptible to recurrence and metastasis. The therapeutic drugs are limited due to the lack of effective biomarkers predicting the therapeutic efficacy and prognosis of disease. Previous studies have shown that platinum-containing regimens are effective for both early and advanced TNBC, therefore, it is particularly important to explore biomarkers for predicting the efficacy of platinum drugs and to screen the population sensitive to platinum drugs. Methods All patients with available tumor specimens from National Cancer Center in China were eligible for this prospective-retrospective study (n=189), including 149 patients with early TNBC (NCT01150513, CH-BC-007) and 40 patients with advanced TNBC (12-123/657, CH-BC-018) who are treated with or without platinum. The primary endpoint is disease-free survival (DFS) for early TNBC and progression free survival (PFS) for advanced TNBC. For HRD status and genomic signatures, indexed libraries were subjected to probe-based hybridization with a customized NGS panel targeting 733 cancer-related genes. 3DMed-HRD algorithm was evaluated based on loss of heterozygosity score (LOH), telomeric allelic imbalance score (TAI) and large-scale state transition score (LST) to characterize genomic instability using over 10,000 single-nucleotide polymorphisms distributed across human genome, adjusted by tumor ploidy and purity. HRD positive is defined by HRD score above the threshold (cut-off ≥30) and/or deleterious mutation in BRCA1/2. ResultsDeleterious BRCA1/2 mutations were detected in 21.2% (40/189) of TNBC patients and 48.1% (91/189) were defined as HRD positive. In advanced TNBC cohort, 21 patients received platinum-containing and 19 received platinum-free chemotherapy regimens for first-line chemotherapy. The progression-free survival (PFS) of the platinum-containing group was longer than that of the platinum-free group (median PFS 9.13 vs 2.97 months, HR 0.39, 95%CI, 0.19-0.81, P=0.011), and the PFS of patients with HRD positive was significantly longer than HRD negative patients (median PFS 13.6 vs 6.80 months, HR 0.38, 95%CI, 0.15-0.99, P=0.048) in platinum-containing group. Interestingly, HRD-positive patients have a significantly shorter PFS than HRD-negative in platinum-free group (median PFS 1.97 vs 4.52 months, HR 3.67, 95%CI, 1.20-11.22, P=0.023). For the HRD-positive patients, median PFS was significantly better in platinum-based group than platinum-free group (median PFS 13.6 vs 1.97 months, HR 0.12, 95%CI, 0.03-0.43, P=0.001). In early-stage TNBC cohort (n=149), 74 patients received platinum-containing and 75 received platinum-free chemotherapy regimens for adjuvant chemotherapy. In platinum-containing group, no statistically significant difference was found in DFS between HRD-positive and HRD-negative patients (P=0.118). High-risk TNBC group (Ki-67 ≥ 15%) analysis revealed that HRD-positive patients had a numerical better DFS than HRD-negative patients (HR 0.43, 95%CI, 0.12-1.50, P=0.180). Among patients with HRD-positive, patients in platinum-containing group had a tendency to benefit more than those in platinum-free group (HR 0.35, 95%CI, 0.11-1.10, P=0.062). Conclusions: We developed a novel algorithm to evaluate 3DMed-HRD status and highlights the potential utility of HRD in guiding chemotherapy for TNBC patients in this retrospective analysis. In comparison to platinum-free chemotherapy, the advanced TNBC HRD positive patients with advanced TNBC receiving platinum-based chemotherapy is a preferable regimen, and the HRD negative patients might be on the contrary. Prospective validation with larger sample size is needed. Citation Format: Yimeng Chen, Xue Wang, Feng Du, Jian Yue, Yiran Si, Lina Cui, Bei Zhang, Binghe Xu, Peng Yuan. The status of homologous recombination deficiency is a potential biomarker for platinum-based chemotherapy in triple-negative breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-08-12.
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Dissertations / Theses on the topic "Yue du jiao xue"

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Lai, Yui-ping, and 黎蕊萍. "Using schema reading strategy to enhance senior form student's reading comprehension ability = Yun yong tu shi yue du jiao xue ce lüe ti sheng gao zhong xue sheng yue du neng li." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/198861.

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This dissertation based on the Cognitive Load Theory, focuses on the effectiveness of using schema reading strategy to enhance secondary five students’ reading comprehension ability. An action research, consists of designing reading worksheets, tests, guiding students using schema reading strategy and observing lessons, in order to promote students’ self-monitoring skill during reading comprehension as well as the effectiveness of the research. The findings conclude: (1) a positive significant on the effects of cognitive load management by modifying the teaching materials for students; (2) using schema reading strategy to enhance secondary five students’ reading comprehension ability. 本研究目的在於應用認知負荷理論，設計一個提升香港中學五年級學生閱讀策略的教學課程，以探討圖式閱讀策略對提升高中學生閱讀能力的成效。本行動研究利用閱讀教材、閱讀測卷和課堂觀察，進行兩個循環的閱讀教學過程，包括計劃、實踐、觀察和反思，藉以調整教學設計和教學模式。結果發現，認知負荷理論對閱讀教學設計的重要性，老師應確保閱讀教材具適度的認知負荷，以免妨礙學生的閱讀效能，亦應注意訓練學生運用圖式閱讀策略，適當地自我監控閱讀過程，從而提升閱讀能力。
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Tsui, Sze-ki, and 徐詩琪. "A study of teaching of reading strategies to enhance the comprehension monitoring awareness of upper primary students in Hong Kong = Yue du ce lüe jiao xue dui cu jin xiao xue gao nian ji xue sheng de yue du li jie jian kong zhi jue de ying xiang." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/198877.

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Ever since the curriculum reform was launched, 'Reading to Learn' has been one of the four key tasks initiated. The result shown in Progress in International Reading Literacy Study (PIRLS,2011) reflected that the reading ability of Hong Kong Primary students is among the best in the world, whereas their reading motivation ranking the last. Researchers also found in the Programme for International Student Assessment (PISA, 2009) conducted among secondary students that their metacognitive level is the lowest among all the secondary students in South-east Asian districts. It reflected that Hong Kong students lack self-regulation and comprehension monitoring awareness in reading. This dissertation is written in support of an action research and a case study. It aims to discuss the impact on the implementation of teaching of reading strategies on four different primary students, who are of diverse ability on comprehension. In the action research, the researcher tries to enhance students' comprehension monitoring awareness through introducing the K-W-L Chart and Directed Reading and Thinking Activity. In the case study, the researcher makes use of think aloud activities and student interviews to collect and analyze the qualitative data obtained. Together with the quantitative analysis, the researcher studies the reading strategies used among the four selected primary 4 students as well as their understanding toward reading strategies before and after they received the teaching in the process. The research result reflects that teaching reading strategies has a significant effect on enhancing student's reading comprehension monitoring awareness among students, especially the lower ability students. Furthermore, this research makes a few practical suggestions on how to enhance students' reading comprehension awareness in daily teaching. 自課程改革(以下簡稱「課改」)以來，「從閱讀中學習」一直為課改四大關鍵項目之一。「全球學生閱讀能力進展研究(PIRLS，2011)」的結果反映本港小學生的閱讀能力冠絕全球，閱讀動機卻在全球榜尾的奇怪現象；而以中學生為對象的「學生基礎素養能力計劃(PISA，2009)」亦發現本港學生的後設認知能力水平為全東南亞地區最差，反映本港學生在閱讀方面缺乏自我調整和閱讀監控的意識。 本論文旨在以行動研究(action research)及個案研究(case study)方式，探討閱讀策略教學對促進四位小學四年級不同能力學生的閱讀理解監控知覺的影響。在行動研究方面，研究員通過教授自我檢測圖及引領思維閱讀策略，促進學生的理解監控知覺。在個案研究方面，通過放聲思考(think aloud)活動及學生訪談，搜集及分析質性數據，並結合量性分析，探討本港某小學四位四年級學生於接受教學前後，在閱讀過程中運用閱讀策略的情況，以及他們對閱讀策略的認識。研究結果反映，閱讀策略教學對促進學生的閱讀理解監控知覺對於閱讀能力較弱的學生，有明顯的影響。此外，本研究就如何在日常教學中教授閱讀策略，以提升學生的閱讀理解監控知覺方面提出一些建議。
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Chan, Kok-chi. "Effectiveness of computer-assisted learning in Chinese language Dian nao fu zhu zhong wen yue du jiao xue zhi cheng xiao ping gu /." Click to view the E-thesis via HKUTO, 1998. http://sunzi.lib.hku.hk/hkuto/record/B31959969.

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To, Suk-kwan. "The effectiveness of a reading module in enhancing junior students' reading motivation and conceptual knowledge Ti sheng chu zhong xue sheng yue du dong ji ji wen hua zhi shi dan yuan jiao xue cheng xiao yan jiu /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B40039985.

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Chen, Minzhen. "Meiguo tu shu guan xue hui yu Yingguo tu shu guan xue hui dui tu shu guan shi ye fa zhan zhi bi jiao yan jiu." Taibei Shi ; Niuyue : Han mei tu shu you xian gong si, 1990. http://books.google.com/books?id=6LTSAAAAMAAJ.

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Dung, Chau-hung. "Poetics of Ye Xie and of the Lingnan master poet trio a comparative study = Ye Xie yu ling nan san jia shi lun bi jiao yan jiu /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B4098767X.

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Luo, Yin. ""Kong", "you" yu "you", "wu" : xuan xue yu bi re xue jiao hui wen ti zhi yan jiu /." Tai Bei : Guo li Tai Wan da xue, 2003. http://catalogue.bnf.fr/ark:/12148/cb39291212m.

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Th. doct.--Philosophie--Taibei--National Taiwan University = Guo li Tai Wan da xue, 2000.
Mention parallèle de titre ou de responsabilité : "Sunyata", "Dravysati" & "yo", "wo" : ontological research for the combination of Chinese metaphysic and Indian Prajna philosophy in A.D.300-500. Bibliogr. p. 385-399.
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Li, Pei. "Sui Tang wu dai dao jiao mei xue si xiang yan jiu." Chengdu Shi : Sichuan chu ban ji tuan Ba Shu shu she, 2005.

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Kong, Ching-man Paula. "The effectiveness of genre approach to teaching book report writing to senior secondary students Wen lei gong neng jiao xue fa zai du shu bao gao xie zuo jiao xue de cheng xiao /." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38203376.

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Wu, Tsz Wing. "Li Yu gai bian ju yan jiu : jian lun wen ren chuan qi yu shi min wen xue zhi rong he /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?HUMA%202006%20WU.

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Books on the topic "Yue du jiao xue"

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Shu, Ding Fang. Kuai su yue du. Shang hai shi: Shang hai wai yu jiao yu chu ban she, 2007.

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xu, Cui. Ao er fu yin yue jiao xue fa. Bei jing: Bei jing chu ban she, 2014.

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qian, Zhang. Yin yue mei xue jiao cheng. Shang hai: Shang hai yin le chu ban she, 2002.

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Jiankun, Xu, ed. Xie zuo jiao shi: Yue du wen xue ming jia. Taibei Shi: Mai tian chu ban, 2004.

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hua, Kong yun. Da xue ying yu yue du jiao cheng. Bei jing: Wai yu jiao xue yu yan jiu chu ban she, 1988.

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jun, Chen. Ying yu xi lie yue du xun lian 100 pian: Yue du ying yu. Bei jing: Xin shi jie chu ban she, 1999.

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jun, Chen. Ying yu xi lie yue du xun lian 100 pian: Yue du yu yan. Bei jing: Xin shi jie chu ban she, 1999.

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Allen, Sandra, and Gao gui zhen. Gao xiao ying yu yue du. Shang hai: Shang hai wai yu jiao yu chu ban she, 2001.

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Dingfang, Shu. Kuai su yue du =: Reading faster. Shanghai: Shang hai wai yu jiao yu chu ban she, 2009.

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mei, Xia ji, and Jia de na. Da xue xue shu ying yu du xie jiao cheng: Xue sheng yong shu. Shang hai: Shang hai wai yu jiao yu chu ban she, 2013.

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Book chapters on the topic "Yue du jiao xue"

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Lambert, Tristan H. "Advances in Heterocyclic Aromatic Construction." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0068.

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Rubén Vicente and Luis A. López at the University of Oviedo in Spain reported (Angew. Chem. Int. Ed. 2012, 51, 8063) the synthesis of cyclopropyl furan 2 from alkylidene 1 and styrene by way of a zinc carbene intermediate. The same substrate 1 was also converted (Angew. Chem. Int. Ed. 2012, 51, 12128) to furan 3 via catalysis with tetrahydrothiophene in the presence of benzoic acid by J. Stephen Clark at the University of Glasgow. Xue-Long Hou at the Shanghai Institute of Organic Chemistry discovered (Org. Lett. 2012, 14, 5756) that palladacycle 6 catalyzes the conversion of bicyclic alkene 4 and alkynone 5 to furan 7. A silver-mediated C–H/C–H functionalization strategy for the synthesis of furan 9 from alkyne 8 and ethyl acetoacetate was developed (J. Am. Chem. Soc. 2012, 134, 5766) by Aiwen Lei at Wuhan University. Ning Jiao at Peking University and East China Normal University found (Org. Lett. 2012, 14, 4926) that azide 10 and aldehyde 11 could be converted to either pyrrole 12 or 13 with complete regiocontrol by judicious choice of a metal catalyst. Meanwhile, Michael A. Kerr at the University of Western Ontario developed (Angew. Chem. Int. Ed. 2012, 51, 11088) a multicomponent synthesis of pyrrole 16 involving the merger of nitrone 14 and the donor–acceptor cyclopropane 15. The pyrrole 16 was subsequently converted to an intermediate in the synthesis of the cholesterol-lowering drug compound Lipitor. A robust synthesis of the ynone trifluoroboronate 17 was developed (Org. Lett. 2012, 14, 5354) by James D. Kirkham and Joseph P.A. Harrity at the University of Sheffield, which thus allowed for the ready production of trifluoroboronate-substituted pyrazole 18. An alternative pyrazole synthesis via oxidative closure of unsaturated hydrazine 19 to produce 20 was reported (Org. Lett. 2012, 14, 5030) by Yu Rao at Tsinghua University. A unique fluoropyrazole construction was developed (Angew. Chem. Int. Ed. 2012, 51, 12059) by Junji Ichikawa at the University of Tsukuba that involved nucleophilic substitution of two of the fluorides in 21 to form pyrazole 22.
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Confucio. "Acción de lo interno." In Enseñanzas para la vida y el gobierno: dos textos confucianos, el Da Xue y el Zhong Yong, 27–43. Pontificia Universidad Católica del Perú, 2023. http://dx.doi.org/10.18800/9789972426667.002.

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Llámase innato (xing) a lo [recibido por] mandato del Cielo (Tian ming). Llámase camino (dao) a la conducción de lo innato [en consecuencia con el mandato del Cielo]. Llámase doctrina (jiao) a la formación de [acuerdo con el] camino. El camino es aquello que no puede ser abandonado ni un instante; lo que puede ser abandonado no es el camino. Por ello, el soberano [de sí mismo] es cauteloso respecto de lo que no ve y temeroso respecto de lo que no escucha. No hay nada más visible que lo oculto y no hay nada más evidente que lo diminuto. Por ello, el soberano [de sí mismo] guarda cautela cuando está solo. Se llama interno (zhong) al [estado] que precede a la emisión del gusto, del disgusto, del pesar y la alegría. Se llama armonía (he) a la emisión [de estas pasiones] dentro de límites internos. Lo interno es la gran raíz de todo cuanto existe bajo el Cielo; la armonía es el camino de llegada de todo cuanto existe bajo el Cielo. En [el estado de] máxima interioridad y armonía, el Cielo y la tierra [ocupan] sus posiciones y las diez mil cosas [obtienen] crianza.
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Taber, Douglass F. "Metal-Mediated Carbocyclic Construction: The Whitby Synthesis of (+)-Mucosin." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0075.

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Erick M. Carreira of ETH-Zürich generated (Org. Lett. 2012, 14, 2162) ethyl diazoacetate in situ in the presence of the alkene 1 and an iron catalyst to give the cyclopropane 3. Joseph M. Fox of the University of Delaware inserted (Chem. Sci. 2012, 3, 1589) the Rh carbene derived from 5 into the alkene 4 to give the cyclopropene 6, without β-hydride elimination. Masaatsu Adachi and Toshio Nishikawa of Nagoya University reduced (Chem. Lett. 2012, 41, 287) the enone 7 to give the cyclobutanol 8. Intramolecular ketene cycloaddition has been limited to very electron-rich acceptor alkenes. Xiao-Ping Cao and Yong-Qiang Tu of Lanzhou University devised (Chem. Sci. 2012, 3, 1975) a protocol that converted 9 into the cyclobutanone 10 with high diastereocontrol. The intermediate is the tosylhydrazone of the ketone, so a reductive workup would lead to the corresponding cycloalkane. Koichi Mikami of the Tokyo Institute of Technology added (J. Am. Chem. Soc. 2012, 134, 10329) alkyl cuprates to the prochiral enone 11 to give the enolate trapping product 13 in high ee and with high diastereocontrol. Marcus A. Tius of the University of Hawaii found (Angew. Chem. Int. Ed. 2012, 51, 5727) a Pd catalyst for the Nazarov cyclization of 14 to 15. Antoni Riera and Xavier Verdaguer of the Universitat de Barcelona prepared (Org. Lett. 2012, 14, 3534) 16 by enantioselective Pauson-Khand addition to tetramethyl norbornadiene. Conjugate addition followed by retro Diels-Alder could potentially lead to the cyclopentenone 17. The intermolecular Pauson-Khand cyclization often gives mixtures of regioisomers. José Barluenga of the Universidad de Oviedo demonstrated (Angew. Chem. Int. Ed. 2012, 51, 183) an alternative, the addition of an alkenyl lithium 19 to the Fischer carbene 18 leading to 20. Jian-Hua Xie and Qi-Lin Zhou of Nankai University hydrogenated (Adv. Synth. Catal. 2012, 354, 1105; see also Org. Lett. 2012, 14, 2714) the ketone 21 under epimerizing conditions to give the alcohol 22. Kozo Shishido of the University of Tokushima observed (Tetrahedron Lett. 2012, 53, 145) that the intramolecular Heck cyclization of 23 proceeded with high diastereocontrol. Zhi-Xiang Yu of Peking University devised (Org. Lett. 2012, 14, 692) an Rh catalyst for the cyclocarbonylation of 25 to 26.
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"Glossary Bailian Jiao White Lotus teachings baimiao paying homage at the temples ban band caijie street procession cha, ban small cymbals chi hui hold a feast for all the households chuige songs for winds chuigu shou drumers and wind players dangzi gong in frame daqu large pieces dizi transverse flute with kazoo membrane fang dengke releasing the lanterns fangshe or shishi pardon and distribution of food fang hedeng releasing the river lanterns gongche traditional notation gu large barrel drum guanshi, zan guan helper guanzi double-reed pipe guyueban, chuida ban wind-and-percussion band huahui assembly of performing troupes hui association huishou association head nanyue the southern music nao, bo large cymbals pai prelude paizi percussion pieces, cf. the melodic qupai qu pieces qupai labelled melodies shang miao going to the temple shan hui charitable associations she society she hui altar assembly shen body sheng free-reed mouth organ sheng-guan yue type of wind-and-percussion music shenghui outstanding association shifu masters tao suites wei tail xiangshou incense head xiaoqu small pieces xueshi learning the [ritual] business xuyuan make vows to the gods." In Tradition & Change Performance, 48. Routledge, 2012. http://dx.doi.org/10.4324/9780203985656-10.

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Conference papers on the topic "Yue du jiao xue"

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Zhang, L., H. Xu, J. Wang, and H. Jiang. "Research on Mechanism and Main Controlling Factors of Nano Surfactant Imbibition Oil Displacement in Tight Reservoir." In 57th U.S. Rock Mechanics/Geomechanics Symposium. ARMA, 2023. http://dx.doi.org/10.56952/arma-2023-0401.

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ABSTRACT Nano-surfactant is affected by multiple factors. Therefore, it is necessary to study the influence of different factors on the spontaneous imbibition displacement efficiency of nano-surfactant and determine the main control factors affecting the imbibition displacement efficiency. The interaction mechanism between nano-displacement agent and tight oil reservoirs is revealed, and a systematic evaluation method for the interaction mechanism between nano-displacement agent and tight oil reservoirs is established in this paper. The mechanism and main control factors of nano-surfactant imbibition oil displacement in tight oil reservoirs were tested and analyzed, too. The research shows that (1) The nano-particle size structure of nanoemulsion helps to reduce the adsorption of surfactant in the formation. (2) Nanoemulsion will not block the formation and can enter the deep part of tight reservoir. (3) The interfacial tension of nanoemulsion can reduce the seepage resistance on the one hand, and provide power for imbibition replacement on the other hand. (4) The wettability reversal function can convert oil-wet rock into water-wet rock and promote imbibition. (5) Under the same conditions, temperature has great influence on the effect of imbibition. The research results provide strong theoretical and technical support for the further efficient development of tight reservoirs. INTRODUCTION With the development of science and technology and economy, people ‘s demand for oil and gas resources is increasing. Conventional oil and gas resources can no longer meet the current energy supply and demand. After decades of development, the resource exploitation technology of tight oil and gas resources has become increasingly mature, and tight oil and gas resources have occupied an increasingly important position in the exploration and development of global oil and gas resources (Khlaifat, 2011). Tight oil refers to the oil accumulation that occurs in the source rock in the form of adsorption or free state, or in the reservoir rocks such as tight sandstone and tight carbonate rock adjacent to the source rock, without large-scale long-distance migration (Zhou, 2020,2021; Li, 2015; Jia, 2012). Due to the existence of a large number of micro-nano pores in the tight reservoir, the pore structure of the tight reservoir is extremely complex, and the fluid flow inside the reservoir is difficult. However, the existence of micro-nano pores also increases the capillary force in tight reservoirs and enhances the driving force of imbibition (Li, 2015; Jia et al., 2012; Xie, 2013; Liang, 2020; Liang et al., 2018; Penny et al., 2012; Erfani Gahrooei et al., 2017; Liu et al., 2021; Wang and Yang, 2021; Yu and Su, 2015). Because most of the tight oil reservoirs are soaked in crude oil for a long time, the surface of the reservoir is wetted by oil phase, and the capillary force is imbibition resistance. By adding nano-surfactant to the injected water or fracturing fluid, the oil-wetted reservoir is modified to water-wetted, which can achieve the purpose of promoting imbibition and energy-increasing replacement. It is also the main measure to improve the imbibition capacity of foreign fluids in tight reservoirs.
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