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Relevant bibliographies by topics / YWHAE-NUTM2

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Academic literature on the topic 'YWHAE-NUTM2'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "YWHAE-NUTM2"

1

Kenny, Colin, David Grehan, Mevlut Ulas, et al. "Immunophenotype-Genotype Correlations in Clear Cell Sarcoma of Kidney—An Evaluation of Diagnostic Ancillary Studies." Pediatric and Developmental Pathology 23, no. 5 (2020): 345–51. http://dx.doi.org/10.1177/1093526620910658.

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Introduction The purpose of this study was to establish a reliable panel of antibodies for immunohistochemical corroboration of a diagnosis of clear cell sarcoma of kidney (CCSK), taking into consideration the various genotypic subsets of CCSK. Methods We conducted full genotypic analysis for evidence of YWHAE-NUTM2, BCOR internal tandem duplication (ITD), and BCOR-CCNB3 in 68 archival cases of CCSK and then immunostained all cases for CCND1, TLE1, and BCOR along with 63 control samples representing tumor types that may enter into the differential diagnosis of CCSK, including 7 congenital meso

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2

Aw, Sze Jet, and Kenneth Tou En Chang. "Clear Cell Sarcoma of the Kidney." Archives of Pathology & Laboratory Medicine 143, no. 8 (2019): 1022–26. http://dx.doi.org/10.5858/arpa.2018-0045-rs.

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Clear cell sarcoma of the kidney is the second most common primary renal malignancy in childhood. It is histologically diverse, making accurate diagnosis challenging in some cases. Recent molecular studies have uncovered BCOR exon 15 internal tandem duplications in most cases, and YWHAE-NUTM2 fusion in a few cases, with the remaining cases having other genetic mutations, including BCOR-CCNB3 fusion and EGFR mutations. Although clear cell sarcoma of the kidney has no specific immunophenotype, several markers including cyclin D1, nerve growth factor receptor, and BCOR (BCL6 corepressor) have eme

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3

Brahmi, Mehdi, Tatiana Franceschi, Isabelle Treilleux, et al. "Molecular Classification of Endometrial Stromal Sarcomas Using RNA Sequencing Defines Nosological and Prognostic Subgroups with Different Natural History." Cancers 12, no. 9 (2020): 2604. http://dx.doi.org/10.3390/cancers12092604.

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A series of 42 patient tumors diagnosed as endometrial stromal sarcoma (ESS) based on the morphology but negative for JAZF1 and/or YWHAE rearrangement in FISH was analyzed by RNA-sequencing. A chromosomal rearrangement was identified in 31 (74%) of the cases and a missense mutation in known oncogenes/tumor suppressor genes in 11 (26%). Cluster analyses on the expression profiles from this series together with a control cohort composed of five samples of low grade ESS harboring a JAZF1-SUZ12 fusion, one high grade ESS harboring a BCOR-ITD, two uterine tumors resembling ovarian sex cord tumors,

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4

Shah, Varsha I., and W. Glenn McCluggage. "Cyclin D1 Does Not Distinguish YWHAE-NUTM2 High-grade Endometrial Stromal Sarcoma From Undifferentiated Endometrial Carcinoma." American Journal of Surgical Pathology 39, no. 5 (2015): 722–24. http://dx.doi.org/10.1097/pas.0000000000000427.

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5

Abdullayeva, R.O, and N.I Tursunova. "ENDOMETRIAL STROMAL SARKOMALARNING GETEROGENLIGI VA O'SIMTA MIKRO-MUHITINING TERAPEVTIK JAVOBGA TA'SIRI." Multidisciplinary Journal of Science and Technology 5, no. 5 (2025): 1205–9. https://doi.org/10.5281/zenodo.15532041.

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Endometrial stromal sarkoma (ESS) bachadonning kam uchraydigan malign o‘smalaridan biri bo‘lib, uning molekulyar va gistologik xilma-xilligi davolash natijalariga sezilarli ta’sir ko‘rsatadi. Ushbu kasallikning heterogen tabiati individual davolash strategiyalarini ishlab chiqishni qiyinlashtiradi. Tadqiqot ESSning molekulyar geterogenligi va o‘simta mikro-muhitining (TME) terapevtik javobga ta’sirini o‘rganadi. JAZF1-SUZ12 va YWHAE-NUTM2B kabi genetik translokatsiyalar o‘simtaning klinik kechishi, o‘sish tezligi va davolashga chidamliligin

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6

Ou, Wen-Bin, Meijun Z. Lundberg, Shuihao Zhu, et al. "YWHAE-NUTM2 oncoprotein regulates proliferation and cyclin D1 via RAF/MAPK and Hippo pathways." Oncogenesis 10, no. 5 (2021). http://dx.doi.org/10.1038/s41389-021-00327-w.

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AbstractEndometrial stromal sarcoma (ESS) is the second most common subtype of uterine mesenchymal cancer, after leiomyosarcoma, and oncogenic fusion proteins are found in many ESS. Our previous studies demonstrated transforming properties and diagnostic relevance of the fusion oncoprotein YWHAE–NUTM2 in high-grade endometrial stromal sarcoma (HG-ESS) and showed that cyclin D1 is a diagnostic biomarker in these HG-ESS. However, YWHAE–NUTM2 mechanisms of oncogenesis and roles in cyclin D1 expression have not been characterized. In the current studies, we show YWHAE-NUTM2 complexes with both BRA

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7

Alkanat, Nazli Eylem, Aysegul Uner, and Alp Usubutun. "High-grade Endometrial Stromal Sarcoma: Morphologic and Clinical Features, the Role of Immunohistochemistry and Fluorescence in Situ Hybridization in Diagnosis." International Journal of Surgical Pathology, May 4, 2022, 106689692210980. http://dx.doi.org/10.1177/10668969221098087.

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Introduction. High-grade endometrial stromal sarcomas (HGESS) are rare malignant mesenchymal tumors of the uterus with aggressive poor clinical outcome, which frequently exhibit YWHAE::NUTM2 and ZC3H7B::BCOR fusions. In this study, we aimed to investigate HGESSs with YWHAE and BCOR translocations through our archive materials, and to identify morphological, immunohistochemical and molecular features of these tumors. We also assessed the diagnostic value of BCOR immunohistochemistry (IHC) in HGESSs, low-grade endometrial stromal sarcomas (LGESS) and uterine leiomyosarcomas. Methods. One hundred

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8

Devins, Kyle M., Ayoma D. Attygalle, Sabrina Croce, Katherine Vroobel, Esther Oliva, and W. Glenn McCluggage. "Uterine Endometrial Stromal Tumors With Pure Low-Grade Morphology Harboring YWHAE::NUTM2 Fusions." American Journal of Surgical Pathology Publish Ahead of Print (April 10, 2023). http://dx.doi.org/10.1097/pas.0000000000002041.

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9

Kommoss, Felix K. F., Lisa-Marie Mar, Brooke E. Howitt, et al. "High-Grade Endometrial Stromal Sarcomas With YWHAE::NUTM2 Gene Fusion Exhibit Recurrent CDKN2A Alterations and Absence of p16 Staining is a Poor Prognostic Marker." Modern Pathology, January 2023, 100044. http://dx.doi.org/10.1016/j.modpat.2022.100044.

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