Log in

Relevant bibliographies by topics / Zambia Adult Education Advisory Board / Journal articles

To see the other types of publications on this topic, follow the link: Zambia Adult Education Advisory Board.

Journal articles on the topic 'Zambia Adult Education Advisory Board'

Author: Grafiati

Published: 28 July 2024

Last updated: 30 July 2024

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Zambia Adult Education Advisory Board.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Ibidunni, Laura, Kristin Paulyson Nunez, Jude C. Jonassaint, and Laura De Castro. "Regional Differences in the Beliefs and Practices Among Adults with Sickle Cell Disease Regarding Reproductive Health and Family Planning: A Sub-Analysis." Blood 134, Supplement_1 (2019): 2114. http://dx.doi.org/10.1182/blood-2019-129554.

Full text

Abstract:

Background. Sickle cell disease (SCD) remains the most common genetic hematologic disorder, with a disproportionally high incidence and prevalence in African countries. It is associated with an increased risk of maternal and infant morbidity and mortality compared to the general population. As more young adults living with SCD reach healthier reproductive ages, it is imperative that there is open communication between providers and patients regarding reproductive health, maternal risks associated with childbirth, and the risk of having children who inherit SCD. It is also important that provid

APA, Harvard, Vancouver, ISO, and other styles

2

Habibi, Anoosha, Stephanie Ngo, Etienne Audureau, et al. "Causes of Death in 198 Sickle Cell Adult Patients: Old and New Trends." Blood 134, Supplement_1 (2019): 1031. http://dx.doi.org/10.1182/blood-2019-131304.

Full text

Abstract:

Introduction: Over the past decades, there have been substantial improvements in the medical care of sickle cell patients, leading to an increase in life expectancy, despite the fact that the latest studies in adults do not see any change in age at death. Pediatric mortality has declined significantly with the introduction of systematic antibiotics, the preventive care cerebral vasculopathy and therapeutic education for families. It seems important to analyze the morbidity and mortality risks to decide the necessary preventive measures. In this study we will describe the circumstances of death

APA, Harvard, Vancouver, ISO, and other styles

3

Liu, Zhi-Jian, Emoke Deschmann, Haley E. Ramsey, et al. "Dose-Dependent Iron Chelating Effects of Eltrombopag on in Vitro Human Megakaryopoiesis." Blood 134, Supplement_1 (2019): 2475. http://dx.doi.org/10.1182/blood-2019-131895.

Full text

Abstract:

Eltrombopag (ELT), a small molecular thrombopoietin (TPO) mimetic approved for children and adults, could offer a therapeutic alternative to selected neonates and young children with chronic thrombocytopenias. ELT has also been proposed as a potential anti-cancer drug due to its anti-proliferative effects in tumor cells, which are mediated by its strong iron chelating properties. This raises the potential concern that rapidly proliferating normal cells, like bone marrow cells in neonates or young infants, could also be susceptible to the anti-proliferative effects of ELT. In this study, we fir

APA, Harvard, Vancouver, ISO, and other styles

4

Duncan, Alexander, Angela Kellum, Shilpa Jain, et al. "Disease Burden in Patients with Glanzmann Thrombasthenia: Perspectives from the Glanzmann Thrombasthenia Patient/Caregiver Questionnaire." Blood 134, Supplement_1 (2019): 3456. http://dx.doi.org/10.1182/blood-2019-128408.

Full text

Abstract:

Introduction: Glanzmann thrombasthenia (GT) is a rare bleeding disorder (~1:1,000,000) caused by impaired function of platelet glycoprotein IIb/IIIa responsible for aggregation. This novel survey was designed to identify the burden of GT through better understanding of the management of the disorder and its psychosocial impact on patients and caregivers. Methods: Participants were recruited via a rare disease specialty recruiter from Comprehensive Health Education Services. Data were collected from January 31 through March 12, 2019, via a moderator-assisted online survey. On average, the surve

APA, Harvard, Vancouver, ISO, and other styles

5

Panayiotidis, Panayiotis, Gayane Tumyan, Catherine Thieblemont, et al. "Primary Analysis of the Tegar Study: A Phase II Study Exploring the Safety and Efficacy of Atezolizumab in Combination with Obinutuzumab or Rituximab in Patients with Relapsed or Refractory (R/R) Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), or Waldenstrom Macroglobulinemia (WM)." Blood 136, Supplement 1 (2020): 2–3. http://dx.doi.org/10.1182/blood-2020-137087.

Full text

Abstract:

Introduction:Treatment options for R/R MCL, MZL and WM are limited. New combinations are in development. A previous Phase Ib study evaluating atezolizumab (A) in combination with obinutuzumab (O) in patients (pts) with R/R NHL reported no new safety signals and overall response rates of 57% and 16% in follicular lymphoma and diffuse large B-cell lymphoma pts, respectively (Palomba, et al. ICML 2017). The Phase II TEGAR study (EudraCT: 2016-003579-22) evaluated the safety and efficacy of A in combination with O or rituximab (R) in pts with R/R MCL, MZL or WM. Methods:R/R MCL or WM pts received

APA, Harvard, Vancouver, ISO, and other styles

6

Sriskandarajah, Priya, Clare Oni, Claire Woodley, et al. "'Application of Prognostic Scoring in Systemic Mastocytosis Patients within a UK Centre of Excellence: Guys and St Thomas' NHS Foundation Trust.'." Blood 138, Supplement 1 (2021): 3625. http://dx.doi.org/10.1182/blood-2021-152234.

Full text

Abstract:

Abstract Background: Systemic mastocytosis (SM) is a disorder of neoplastic mast cells ranging from indolent to aggressive multi-system disease. We previously reported our large single centre experience managing SM. Since 2019 patients have had access to new treatments within trials. Prognostic scoring systems developed in SM to improve outcome predictions and guide treatment have been a focus of recent studies, although are yet to be validated in real-world setting. We sought to apply these scoring systems within our UK cohort, with a particular focus on the international prognostic score (IP

APA, Harvard, Vancouver, ISO, and other styles

7

Geissler, Jan, Fabio Efficace, Felice Bombaci, et al. "Factors Predicting Intentional Non-Adherence In Chronic Myeloid Leukemia: A Multivariate Analysis On 2546 Patients By The CML Advocates Network." Blood 122, no. 21 (2013): 4023. http://dx.doi.org/10.1182/blood.v122.21.4023.4023.

Full text

Abstract:

Abstract Background Adherence to the prescribed dose of tyrosine kinase inhibitors (TKIs) is critical to maximize treatment effectiveness in chronic myeloid leukemia (CML). While patient-centered outcome studies are lacking in this area, literature has shown that a significant proportion of patients report both intentional and unintentional non-adherence. Objective The main objective of this multivariate analysis was to identify risk factors that might predict intentional non-adherence to TKIs in CML. Methods The CML Advocates Network, connecting 79 CML patient groups from 63 countries, conduc

APA, Harvard, Vancouver, ISO, and other styles

8

El-Jawahri, Areej, Christa Meyer, Lih-Wen Mau, et al. "What Do Patients Think about Palliative Care? a National Survey of Hematopoietic Stem Cell Transplant Recipients." Blood 138, Supplement 1 (2021): 2968. http://dx.doi.org/10.1182/blood-2021-149766.

Full text

Abstract:

Abstract Background: Palliative care (PC) benefits patients with cancer and those undergoing hematopoietic stem cell transplantation (HSCT), but remains under-utilized in HSCT. While transplant physicians have substantial concerns regarding how patients perceive PC, studies examining HSCT recipients' perceptions of PC are lacking. Methods: Between 11/2020-4/2021, the CIBMTR Survey Research Group conducted a multi-site cross-sectional survey of adult autologous and allogeneic HSCT recipients at 11 transplant centers in the United States who were 3-12 months post-transplant to assess their exper

APA, Harvard, Vancouver, ISO, and other styles

9

Marchesi, Francesco, Jon Salmanton-García, Alberto Lopez-Garcia, et al. "COVID-19 Infection in Vaccinated Adult Patients with Hematological Malignancies. Preliminary Results from Epicovideha (Epidemiology of COVID-19 infection in patients with hematological malignancies: A European Haematology Association Survey)." Blood 138, Supplement 1 (2021): 3733. http://dx.doi.org/10.1182/blood-2021-147295.

Full text

Abstract:

Abstract Introduction Coronavirus disease 2019 (COVID-19) is a life-threatening condition of high relevance for co-morbid patients, such as those with baseline hematological malignancies (HM). One year after the diagnosis of the first COVID-19 case, at the end of 2020, the first vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were administered to the population, starting with individuals at highest risk of infection. EPICOVIDEHA aims to describe the epidemiology, vaccination strategies and mortality rates from HM patients at risk. Methods We collected clinical

APA, Harvard, Vancouver, ISO, and other styles

10

Nguyen, An Thi, Sharon Burnside, Kristin Junge, Emily Kling Somerville, Marian Keglovits, and Susan Lynn Stark. "Synergizing geriatric research and education in an allied health profession with an older adult community advisory board: development and process outcomes." Educational Gerontology 46, no. 8 (2020): 486–96. http://dx.doi.org/10.1080/03601277.2020.1780369.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Colton, Zachary A., Charis J. Stanek, Sophia M. Liles, et al. "Study protocol for FUTURES: Testing a web-based reproductive health education program for adolescent and young adult males with sickle cell disease." PLOS ONE 18, no. 7 (2023): e0289039. http://dx.doi.org/10.1371/journal.pone.0289039.

Full text

Abstract:

Individuals with sickle cell disease are increasingly surviving into adulthood, many of whom have interest in future biological parenthood. Reproductive health knowledge is low among adolescent and young adult males and their caregivers. Their understanding of these topics is needed to optimize their reproductive health outcomes. As such, through collaboration with a community advisory board (adolescents and young adults with sickle cell disease and mothers of adolescent and young adult males with sickle cell disease) and digital design team, we developed a web-based sickle cell disease-focuse

APA, Harvard, Vancouver, ISO, and other styles

12

John, Mathew, Ekaterina Koledova, Kanakatte Mylariah Prasanna Kumar, and Harshal Chaudhari. "Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India." International Journal of Endocrinology 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/2967578.

Full text

Abstract:

In clinical practice, every year approximately 150,000 children are referred with short stature (SS) based on a cut-off of fifth percentile. The most important endocrine and treatable cause of SS is growth hormone deficiency (GHD). The lack of reliable data on the prevalence of GHD in India limits estimation of the magnitude of this problem. The diagnosis and treatment of GHD are hurdled with various challenges, restricting the availability of growth hormone (GH) therapy to only a very limited segment of the children in India. This review will firstly summarize the gaps and challenges in diagn

APA, Harvard, Vancouver, ISO, and other styles

13

Nugent, Diane J., Chris Guelcher, Angela Forsyth, et al. "Hemophilia Experiences, Results and Opportunities (HERO) Study: US Respondent Demographics and Impact of Diagnosis On Career and Lifestyle Decisions and Quality of Life." Blood 120, no. 21 (2012): 4244. http://dx.doi.org/10.1182/blood.v120.21.4244.4244.

Full text

Abstract:

Abstract Abstract 4244 Objectives: The HERO initiative was developed to increase understanding of the psychosocial issues impacting people with moderate-severe hemophilia (PWH). Methods: Following ethics review and informed consent, 675 adult PWH (≥ 18) and 561 parents of children with hemophilia (CWH) in 10 countries completed ∼45 min psychosocial assessment including EQ-5D, a health-related visual analog scale (0–100, coded as an eleven-point categorical response), and a 7 point scale assessing pessimistic (1) to optimistic (7) outlook on the next 5 years. US participants were recruited thro

APA, Harvard, Vancouver, ISO, and other styles

14

Saulsberry, Anjelica C., Kristen Howell, Joacy Mathias, et al. "Transition Continuity Promotes Long-Term Retention in Adult Care Among Young Adults with Sickle Cell Disease." Blood 134, Supplement_1 (2019): 4676. http://dx.doi.org/10.1182/blood-2019-129296.

Full text

Abstract:

Introduction: During transition from pediatric to adult care, young adults with sickle cell disease (SCD) experience increased acute healthcare utilization and mortality. Functional transitional programs maintain care quality; however, there is a dearth of program outcomes concerning adult care retention. The St. Jude Transition to Adult Care Program is embedded within a co-located medical home for SCD spanning the ages of 12-25 years. The co-location model bridges pediatric and adult care at three levels: (1) hematology provider (2) neuropsychologist and (3) transition nurse coordinator. Prev

APA, Harvard, Vancouver, ISO, and other styles

15

Muffly, Lori, Jun Yin, Sawyer Jacobson, et al. "Enrollment Characteristics and Outcomes of Hispanic and Black AYA ALL Patients Enrolled on a U.S. Intergroup Clinical Trial: A Comparison of the CALGB 10403 (Alliance) Cohort with U.S. Population-Level Data." Blood 138, Supplement 1 (2021): 337. http://dx.doi.org/10.1182/blood-2021-148804.

Full text

Abstract:

Abstract Introduction According to population-based Surveillance, Epidemiology and End Results (SEER) cancer registry data, approximately 40% of adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) in the United States (U.S.) are Hispanic and 7% are Black and both Hispanic and Black patients have significantly inferior outcomes relative to non-Hispanic Whites (NHW). CALGB 10403, a prospective Phase II clinical trial conducted by the U.S. Intergroup, demonstrated the feasibility of delivering a pediatric-inspired ALL regimen to newly diagnosed AYA ALL patients and found th

APA, Harvard, Vancouver, ISO, and other styles

16

Michel, Marc, Marco Ruggeri, Tomás José González-López, et al. "Safety and Efficacy of the Off-Label Use of Thrombopoietin Receptor Agonists for Immune Thrombocytopenia in Pregnancy: Results from a Multicentre Observational Study." Blood 134, Supplement_1 (2019): 1081. http://dx.doi.org/10.1182/blood-2019-122595.

Full text

Abstract:

Introduction: The management of immune thrombocytopenia (ITP) in pregnancy can be challenging as some patients either do not respond to or tolerate corticosteroids and intravenous immunoglobulin and only very few alternative ITP therapies are available during pregnancy. The use of thrombopoietin receptor agonists (Tpo-RA) which are likely to cross the placenta is not recommended during pregnancy but both romiplostim and eltrombopag have been exceptionally used to treat women with severe and refractory ITP during pregnancy. To better assess safety and efficacy of Tpo-RA during pregnancy, we per

APA, Harvard, Vancouver, ISO, and other styles

17

Boccia, Ralph, Michael A. Boxer, Waleed Ghanima, et al. "Enhanced Responses to Fostamatinib As Second-Line Therapy and in Persistent Immune Thrombocytopenia (ITP) Patients." Blood 134, Supplement_1 (2019): 1069. http://dx.doi.org/10.1182/blood-2019-126473.

Full text

Abstract:

Introduction. Immune thrombocytopenia (ITP) is characterized by autoantibody-mediated platelet destruction resulting in thrombocytopenia and often at least a degree of bruising and bleeding. Platelet destruction occurs within activated macrophages that signal via spleen tyrosine kinase (SYK) following Fcγ receptor engagement by platelet-bound IgG antibodies. Fostamatinib is a SYK inhibitor, taken orally twice daily with or without food. In the three phase 3 clinical studies (2 randomized, controlled trials and 1 open-label extension study), 145 adults with ITP received fostamatinib. These pati

APA, Harvard, Vancouver, ISO, and other styles

18

Gloston, Gabrielle F., S. Justin Thomas, Sarah Maxwell, Jeffrey D. Lebensburger, Julie Kanter, and Alyssa M. Schlenz. "Sleep Characterization of Adolescent and Young Adult Patients with Sickle Cell Disease Using the Pittsburgh Sleep Quality Index." Blood 138, Supplement 1 (2021): 1954. http://dx.doi.org/10.1182/blood-2021-151944.

Full text

Abstract:

Abstract Introduction: Poor sleep quality is common across the lifespan in patients with sickle cell disease (SCD) and has been associated with pain, mood disruption, and fatigue. The Pittsburgh Sleep Quality Index (PSQI) examines sleep quality in both pediatric and adult patients with chronic health conditions, including in adolescents and young adults (AYAs) with SCD. The AYA period is particularly salient for patients with SCD given the potential onset of chronic pain during this developmental period and increased risk for complications during transition. Previous studies have relied on the

APA, Harvard, Vancouver, ISO, and other styles

19

Jain, Tania, Andrea Knezevic, Martina Pennisi, et al. "Hematological Count Recovery in Patients Undergoing Treatment with Chimeric Antigen Receptor T Cells (CAR T)." Blood 134, Supplement_1 (2019): 4455. http://dx.doi.org/10.1182/blood-2019-127480.

Full text

Abstract:

Background: CAR T therapy is FDA approved for specific relapsed/ refractory (R/R) B cell lymphomas and acute lymphoblastic leukemia (ALL), and clinical trials are ongoing for R/R multiple myeloma (MM). Cytopenias have been observed post-CAR T, yet there is minimal data delineating the pathobiology and trends. We report the largest series to our knowledge thus far, of hematological recovery and factors affecting count recovery after CAR T. Methods: We retrospectively reviewed adult patients who received CAR T for R/R B cell lymphomas after FDA approval and those treated for R/R B cell ALL (NCT0

APA, Harvard, Vancouver, ISO, and other styles

20

Tijaro-Ovalle, Natalia M., Shuli Li, Zachariah Defilipp, et al. "Development of HHV-6-Specific Immunity after Cord Blood Transplantation in Adults Depends on Reconstitution of Thymopoiesis and Regeneration of CD4+ T Cells." Blood 134, Supplement_1 (2019): 3275. http://dx.doi.org/10.1182/blood-2019-129154.

Full text

Abstract:

Umbilical cord blood transplantation (UCBT) is an alternative for patients who need hematopoietic stem cell transplant (HSCT), but lack HLA-matched adult donors. Rabbit anti-thymoglobulin (ATG) has been used in UCBT conditioning to achieve T cell depletion, but ATG-induced immunosuppression is associated with delayed immune reconstitution, increased infectious complications and higher non-relapse mortality. In a clinical trial of reduced intensity double-unit UCBT (dUCBT), we substituted low dose total body irradiation (TBI) for ATG to determine whether dUCBT without ATG would alter kinetics a

APA, Harvard, Vancouver, ISO, and other styles

21

Vernon, Marlo M., Samantha Jones, Steven Coughlin, Justin X. Moore, Vahe Heboyan, and Martha Tingen. "Abstract B034: Cancer Health Awareness through Screening and Education (CHANGE): Community health engagement." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (2023): B034. http://dx.doi.org/10.1158/1538-7755.disp22-b034.

Full text

Abstract:

Abstract Purpose The goal of the CHANGE project is to provide a sustainable model of evidence-based cancer awareness through education – with an emphasis on prevention and early detection behaviors. Methods: Residents of a public housing community were invited to participate in a 4-week education program on breast, prostate, and colorectal cancer, including modifiable risk factors of obesity and tobacco use, screening eligibility, and participation in clinical trials. Each session was led by trained research staff, and lasted approximately one hour. A community site survey was also conducted a

APA, Harvard, Vancouver, ISO, and other styles

22

Terriou, Louis, Zelie Guitton, Miguel Hie, et al. "Thrombopoietin-Receptor Agonist in Systemic Lupus Erythematosus Associated Immune Thrombocytopenia: Results of the 16 Patients from the French Cohort." Blood 128, no. 22 (2016): 2542. http://dx.doi.org/10.1182/blood.v128.22.2542.2542.

Full text

Abstract:

Abstract Introduction Systemic Lupus Erythematosus (SLE) is associated with thrombocytopenia in approximately 20 % of cases. Management of such cases has been similar to that of Immune ThrombocytoPenia (ITP) as an immune-mediated mechanism is inferred in the pathogenesis of SLE-associated thrombocytopenia. First line treatment is similar to primary ITP (corticosteroids, intravenous immunoglobulin), with the use of hydroxychloroquin in addition. Immunosuppressive agents, rituximab or splenectomy can be used as second line treatment. However, a significant number of patients will not respond to

APA, Harvard, Vancouver, ISO, and other styles

23

Allemang, Brooke, Kate Allan, Colleen Johnson, et al. "Comprehensive Structured Transition Program with Dedicated Transition Navigator Reduced Lost to Follow-up and Improved Medication Adherence in Sickle Cell Disease and Thalassemia Adolescents and Young Adults." Blood 128, no. 22 (2016): 317. http://dx.doi.org/10.1182/blood.v128.22.317.317.

Full text

Abstract:

Abstract Introduction: Adolescents and young adults (AYA) with sickle cell disease (SCD) and thalassemia transitioning from pediatric to adult health care experience a lack of engagement with adult care providers, are at high risk of loss to follow-up, emergence of psychosocial issues, morbidity and mortality. The shift from a pediatric to an adult setting can be challenging for AYA who are coping with multiple life transitions and are expected to acquire the necessary skills to manage their own care. Hypothesis: implementation of a comprehensive structured transition program with dedicated tr

APA, Harvard, Vancouver, ISO, and other styles

24

Arroyo, Santiago, Renger G. Tiessen, William S. Denney, et al. "Hyper-Sialylated IgG M254, an Innovative Therapeutic Candidate, Evaluated in Healthy Volunteers and in Patients with Immune Thrombocytopenia Purpura: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics." Blood 134, Supplement_1 (2019): 1090. http://dx.doi.org/10.1182/blood-2019-125993.

Full text

Abstract:

Background: Intravenous immunoglobulin (IVIg), a therapeutic blood product prepared from pooled plasma of 3,000-60,000 healthy donors, is the treatment of choice for immunodeficiency syndromes. It has also been used to treat many acute and chronic autoimmune and systemic inflammatory diseases. The precise mechanism of action of IVIg is not well-understood, but occasional long-term effects presumably reflect immunomodulatory and anti-inflammatory properties. Although clinically useful, IVIg has several limitations including variable efficacy, infusion-related side effects, which may be due to p

APA, Harvard, Vancouver, ISO, and other styles

25

Altomare, Ivy, Vadim V. Markovtsov, Leslie Todd, et al. "Potential Anti-Thrombotic Effect without Accompanying Hemorrhage with Fostamatinib Use in Patients with Immune Thrombocytopenia." Blood 134, Supplement_1 (2019): 4889. http://dx.doi.org/10.1182/blood-2019-126558.

Full text

Abstract:

Background Immune thrombocytopenia (ITP) results from autoimmune antibody-mediated destruction of platelets. Bruising and bleeding are hallmarks of ITP, but thromboembolic events (TEEs) are also observed in ITP patients, even thrombocytopenic ones. In population-based cohort studies, chronic ITP patients had two-fold higher risk of a venous TEE compared to the general population.1 The risk of venous or arterial TEE is further elevated in splenectomized ITP patients and those on thrombopoietin receptor agonists (TPO-RAs). Other risk factors include: age > 60 years, prolonged corticosteroid t

APA, Harvard, Vancouver, ISO, and other styles

26

Dawkins, Monique D., Firas El Chaer, Leigh Boehmer, et al. "Education and Promotion of MRD Testing within the Multidisciplinary Cancer Care Team for Adults with Acute Lymphoblastic Leukemia in the Community Setting." Blood 134, Supplement_1 (2019): 5834. http://dx.doi.org/10.1182/blood-2019-123461.

Full text

Abstract:

Background: The Association of Community Cancer Centers (ACCC) is an education and advocacy organization with a diverse membership, representing all cancer program types with the largest majority (75%) being community-based cancer programs and private practices. Beyond the academic setting, ACCC seeks to expand education on the advancements in all cancer care and since measurable residual disease (MRD) is the most important prognostic factor that guides the therapy for patients with acute lymphoblastic leukemia (ALL), this project aimed to emphasize the importance of MRD testing for adult pati

APA, Harvard, Vancouver, ISO, and other styles

27

Grace, Rachael F., and Wilma Barcellini. "Survey of 275 Patients and Caregivers Affected By Pyruvate Kinase Deficiency: Impact of Communication with Hematologists on Mental Health and Quality of Life." Blood 138, Supplement 1 (2021): 1948. http://dx.doi.org/10.1182/blood-2021-152326.

Full text

Abstract:

Abstract Background. Pyruvate Kinase deficiency (PKD) is a rare congenital hemolytic anemia which affects approximately three people per million individuals worldwide. With no disease-modifying treatments currently available, management tends to focus on supportive symptom control such as blood transfusions. PKD has a profound, wide-ranging impact on quality of life (QoL). Patient advocacy and patient-reported outcomes research has been limited. The PKD Advocacy Advisory Council (AAC), a group of patients, caregivers, patient advocates and physicians, was formed in 2020, by Agios Pharmaceutica

APA, Harvard, Vancouver, ISO, and other styles

28

Della Pia, Alexandra, Gee Youn Kim, Jaeil Ahn, et al. "Production of Anti-Spike Antibodies in Response to COVID Vaccine in Lymphoma Patients." Blood 138, Supplement 1 (2021): 1347. http://dx.doi.org/10.1182/blood-2021-151367.

Full text

Abstract:

Abstract Background Patients with hematologic malignancies have poor outcomes from COVID infection with associated mortality of up to 30-40%. Studies have shown that these patients are less likely to mount an antibody response after COVID infection 1. The Pfizer-BioNTech and Moderna COVID mRNA vaccines have been shown to be 94% effective in preventing severe disease in the general population. There is limited data on the efficacy of these vaccines in lymphoma patients, and to suggest the optimal timing of vaccination to elicit immunity in patients receiving immunochemotherapy. Methods This is

APA, Harvard, Vancouver, ISO, and other styles

29

Stein, Eytan M., Courtney D. DiNardo, Amir T. Fathi, et al. "Updated Survival and Response Analyses from a Phase 1 Study of Ivosidenib or Enasidenib Combined with Induction and Consolidation Chemotherapy in Patients with Newly Diagnosed AML with an IDH1 or IDH2 Mutation." Blood 138, Supplement 1 (2021): 1276. http://dx.doi.org/10.1182/blood-2021-146507.

Full text

Abstract:

Abstract Background: Ivosidenib (IVO) and enasidenib (ENA) are oral inhibitors of mutant IDH1 (mIDH1) and mutant IDH2 (mIDH2), respectively, FDA-approved for the treatment of relapsed/refractory IDH-mutant acute myeloid leukemia (AML). Here we report updated response and survival results from a phase 1 study of these agents when combined with intensive chemotherapy in patients with newly diagnosed m IDH1/2 AML. Methods: The design of this open-label, multicenter, phase 1 study (NCT02632708) has been previously described. Briefly, eligible patients with newly diagnosed m IDH1 or m IDH2 AML were

APA, Harvard, Vancouver, ISO, and other styles

30

Tollerfield, Sally, Sherwin Criseno, Miriam Fallon, et al. "Facilitating the adherence journey of children, adolescents, and adults on long-term growth hormone therapy." British Journal of Nursing 29, no. 19 (2020): 1118–23. http://dx.doi.org/10.12968/bjon.2020.29.19.1118.

Full text

Abstract:

Growth hormone deficiency in children and adolescents is treated with recombinant growth hormone injections, with the aim of helping patients reach a final height that falls within their genetically predicted adult height. While this treatment is very successful, overcoming issues of patient adherence is a challenge at each stage of the treatment journey, from early childhood to adulthood. An advisory board of senior endocrine nurses convened to discuss what strategies and tools work well in achieving adherence, and the best practices they identified—including the key strategies of choice, inf

APA, Harvard, Vancouver, ISO, and other styles

31

Davila, Jennifer G., W. Beau Mitchell, Kerry A. Morrone, et al. "Venous Thromboembolism Prophylaxis Practices for Patients with Sickle Cell Disease Pre and during the COVID-19 Pandemic." Blood 136, Supplement 1 (2020): 38–39. http://dx.doi.org/10.1182/blood-2020-137071.

Full text

Abstract:

Background: The coronavirus disease pandemic of 2019 (COVID-19) has been associated with coagulopathy and an increased rate of thrombosis in adults. Medical practitioners have been prompted to consider prophylactic anticoagulation in special populations diagnosed with COVID-19. Patients with sickle cell disease (SCD) are predisposed to a hypercoagulable state. Despite the concern for development of venous thromboembolism (VTE) in these patients, there are no standardized guidelines for routine thromboprophylaxis in either adults or children with SCD. Thus, VTE management options are often extr

APA, Harvard, Vancouver, ISO, and other styles

32

Forté, Stéphanie, Maryline Couette, Damien Oudin Doglioni, Denis Soulieres, Kevin H. M. Kuo, and Pablo Bartolucci. "Evidence of Educational Bias in Cognitive Screening of Adults with Sickle Cell Disease: Comparison of Available Tools and Possible Strategies for Mitigation." Blood 136, Supplement 1 (2020): 13–14. http://dx.doi.org/10.1182/blood-2020-143169.

Full text

Abstract:

Background: Cognitive impairment is a dreaded complication of sickle cell disease (SCD) that impacts quality of life, school performance and employment. In 2020, the American Society of Hematology issued a strong recommendation that clinicians supervising the care of adults with SCD conduct surveillance for cognitive impairment using simplified signaling questions (DeBaun, 2020). However, guidance on the optimal screening strategy is lacking and several available tools are biased by language and education. The Rowland Universal Dementia Assessment Scale (RUDAS) was specifically designed for co

APA, Harvard, Vancouver, ISO, and other styles

33

Antonelli, Karla, Jennifer L. Cmar, and Anne Steverson. "Development of 4to24, a Transition Application for Parents of Students With Visual Impairments." Journal of Visual Impairment & Blindness 115, no. 6 (2021): 493–505. http://dx.doi.org/10.1177/0145482x211059190.

Full text

Abstract:

Introduction This article focuses on the development of 4to24, an informational app for parents of students with visual impairments, with emphasis on obtaining stakeholder input, developing content, and establishing content validity. The app provides information, resources, and activities to help students, ages 4–24 years, prepare for independence and employment as an adult. Method App design and content development involved multiple phases of iterative design and writing. Stakeholder input was obtained via an advisory board and user focus groups with parents and students. Experts reviewed and

APA, Harvard, Vancouver, ISO, and other styles

34

Bussel, James B., David J. Kuter, Sylvain Audia, Richard J. Francovitch, and Marc Michel. "Safety and Efficacy of PRTX-100, a Highly Purified Form of Staphylococcal Protein A, in Patients with Immune Thrombocytopenia (ITP)." Blood 128, no. 22 (2016): 4929. http://dx.doi.org/10.1182/blood.v128.22.4929.4929.

Full text

Abstract:

Abstract Background: ITP is a rare autoimmune hematologic disorder characterized by isolated thrombocytopenia caused by antibody-dependent platelet destruction and impaired platelet production. Several therapeutic options (eg glucocorticoids, intravenous immunoglobulin and thrombopoietin receptor agonists) are available to treat patients with ITP, although inadequate efficacy, side effects and/or cost can make them undesirable. PRTX-100 is a highly purified form of Staphylococcal protein A (SpA), which binds to human B-lymphocytes and monocytes, and modulates immune processes. Preclinical data

APA, Harvard, Vancouver, ISO, and other styles

35

Hughes, Mitchell E., Daniel J. Landsburg, Daniel J. Rubin, et al. "Clinical Outcomes of Venetoclax Therapy in Patients with Relapsed/Refractory (r/r) Non Hodgkin Lymphomas (NHL)." Blood 132, Supplement 1 (2018): 1706. http://dx.doi.org/10.1182/blood-2018-99-111194.

Full text

Abstract:

Abstract Introduction: Venetoclax (VEN) is a highly effective agent for chronic lymphocytic leukemia (CLL) that targets BCL-2. Thus, it has been hypothesized to have efficacy in NHL and tested in phase-1/2 studies (Gerecitano JF, Blood 2015; de Vos S, Blood 2015; Davids MS, J Clin Oncol 2017). Overall response rates (ORR) observed in r/r NHL were 44% for all subtypes combined, 38% for follicular lymphoma (FL), 75% for mantle cell lymphoma (MCL), and 18% for diffuse large B-cell lymphoma (DLBCL). The adverse effect profile was consistent with the labeling despite dose escalation to doses higher

APA, Harvard, Vancouver, ISO, and other styles

36

May, Jennifer, Alexis Domeracki, Perisa Ashar, et al. "LGBTQ+ INCLUSIVITY TRAINING AND EDUCATION FOR SKILLED NURSING FACILITIES." Innovation in Aging 7, Supplement_1 (2023): 1074. http://dx.doi.org/10.1093/geroni/igad104.3450.

Full text

Abstract:

Abstract The population of older adults is growing in the United States, leading to greater need for specialized care offered by skilled nursing and long-term care facilities. Among older adults that require specialized health care, lesbian, gay, bisexual, transgender, queer, and other sexual and gender minority (LGBTQ+) older adults are more likely to experience health disparities and health care barriers due to lifelong discrimination and exclusion. Healthcare workers within skilled nursing facilities (SNF) have expressed they do not feel prepared to care for LGBTQ+ older adults. The aim of

APA, Harvard, Vancouver, ISO, and other styles

37

Schuster, Stephen J., Richard T. Maziarz, Solveig G. Ericson, et al. "Consensus Grading of Cytokine Release Syndrome (CRS) in Adult Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (r/r DLBCL) Treated with Tisagenlecleucel on the JULIET Study." Blood 132, Supplement 1 (2018): 4190. http://dx.doi.org/10.1182/blood-2018-99-113052.

Full text

Abstract:

Abstract Introduction: Autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy achieves rapid and durable responses in patients with r/r DLBCL, although unique potential toxicities require specialized management. Cytokine release syndrome (CRS) is the most commonly observed adverse event of special interest associated with CAR T-cell therapy. Two CRS grading scales have been used in different clinical trials of CAR T-cell therapy: the Penn scale (Porter, Sci Transl Med, 2015; Porter, J Hematol & Oncol, 2018) and the Lee scale (Lee, Blood, 2014; Neelapu, Nat Rev Clin Oncol, 2017

APA, Harvard, Vancouver, ISO, and other styles

38

Dahir, Kathryn, Ruban Dhaliwal, Jill Simmons, et al. "Health Care Transition From Pediatric- to Adult-Focused Care in X-linked Hypophosphatemia: Expert Consensus." Journal of Clinical Endocrinology & Metabolism 107, no. 3 (2021): 599–613. http://dx.doi.org/10.1210/clinem/dgab796.

Full text

Abstract:

Abstract Context X-linked hypophosphatemia (XLH) is an inherited skeletal disorder that can lead to lifelong deleterious musculoskeletal and functional consequences. Although often perceived as a childhood condition, children and adults both experience the negative effects of XLH. Adolescents and young adults (AYAs) benefit from effective health care transition (HCT) preparation to support the transfer from pediatric- to adult-focused care. Whereas transition timelines, milestones, and educational tools exist for some chronic conditions, they do not meet the unique needs of patients with XLH.

APA, Harvard, Vancouver, ISO, and other styles

39

Andrade-Gonzalez, Xavier, Anuhya Kommalapati, Allison M. Bock, et al. "Influence of Treatment Facility Type and Annual Patient Volume on Overall Survival in Patients with Mantle Cell Lymphoma: A National Cancer Database Analysis." Blood 138, Supplement 1 (2021): 1348. http://dx.doi.org/10.1182/blood-2021-151888.

Full text

Abstract:

Abstract Introduction: Mantle cell lymphoma (MCL) is an uncommon hematological malignancy with an estimated incidence of 1 per 100,000 persons per year in the United States and represents only about 5% of all non-Hodgkin lymphomas. Several studies have shown that treatment at academic centers and a higher hospital case volume are associated with improved outcomes for uncommon hematological malignancies, probably due to increased provider expertise and access to novel therapies. Treatment of MCL can be complex given the heterogenous nature of the disease and a frequent need for autologous stem

APA, Harvard, Vancouver, ISO, and other styles

40

Papier, Joy. "Acknowledgements." Journal of Vocational, Adult and Continuing Education and Training 2, no. 2 (2019): v. http://dx.doi.org/10.14426/jovacet.v2i2.98.

Full text

Abstract:

We once again acknowledge our reviewers for the insight and developmental critique which they so unstintingly offered. Each journal article is anonymised and subjected to ‘blind’ peer review by two reviewers and, in this process, it is inevitable that variations of interpretation and evaluation occurred, at times resulting in a third reviewer being consulted. We are grateful for the grace with which reviewers engaged and attempted to resolve any sticking points on such occasions. This has served to enhance the quality of our articles and strengthen our authors going forward. Thanks to al

APA, Harvard, Vancouver, ISO, and other styles

41

Barata, Anna, Aasha I. Hoogland, Anuhya Kommalapati, et al. "Change in Patients' Perceived Cognition Among Chimeric Antigen Receptor T-Cell Therapy Recipients at Day 360." Blood 138, Supplement 1 (2021): 3052. http://dx.doi.org/10.1182/blood-2021-150838.

Full text

Abstract:

Abstract Introduction: Chimeric antigen receptor (CAR) T-cell therapy can lead to durable responses in patients with relapsed/refractory hematologic malignancies. Immune effector cell-associated neurotoxicity syndrome (ICANS) occurs in up to 64% of patients. There is concern that ICANS places patients at risk for longer-term cognitive impairment. This study examined changes in patients' perceived cognition from prior to CAR T-cell therapy to days 90 and 360 in patients diagnosed with non-Hodgkins lymphoma, as well as CAR T-cell therapy-specific risk factors (e.g., ICANS, cytokine release syndr

APA, Harvard, Vancouver, ISO, and other styles

42

Saleh, Mansoor N., James B. Bussel, Raymond SM Wong, et al. "Hepatobiliary and Thromboembolic Events during Long-Term E.X.T.E.N.Ded Treatment with Eltrombopag in Adult Patients with Chronic Immune Thrombocytopenia (ITP)." Blood 128, no. 22 (2016): 1368. http://dx.doi.org/10.1182/blood.v128.22.1368.1368.

Full text

Abstract:

Abstract Introduction: ITP, characterized by a reduction in platelets leading to thrombocytopenia, which persists for >12 months is considered chronic (cITP). Eltrombopag is an oral thrombopoietin receptor agonist approved for treatment of patients with cITP aged ≥1 year refractory to other treatments (eg corticosteroids, immunoglobulins). The recently completed Phase III EXTEND (Eltrombopag eXTENded Dosing) study was a global, open-label, extension study of patients with cITP, who received eltrombopag or placebo in prior eltrombopag clinical studies. The primary objective of EXTEND was to

APA, Harvard, Vancouver, ISO, and other styles

43

Boye-Doe, Alexandra, Elizabeth Brown, Charu Puri-Sharma, et al. "The Grndad Registry: Contemporary Natural History Data and an Analysis of Real-World Patterns of Use and Limitations of Disease Modifying Therapy in Adults with SCD." Blood 136, Supplement 1 (2020): 34–36. http://dx.doi.org/10.1182/blood-2020-138895.

Full text

Abstract:

Incremental improvement in care for children with sickle cell disease (SCD), arising from government-funded research over the last 4 decades, resulted in a dramatically reduced childhood mortality. However, the impact of iterative research and disease modifying therapy (DMT) on adults with SCD has not been as strong. Until now, there has been no coordinated, longitudinal, generalizable, natural history study of SCD that allowed for an assessment of the contemporary adult population. Here, we describe demographics at enrollment and cross-sectional clinical characteristics of 570 adults with SCD

APA, Harvard, Vancouver, ISO, and other styles

44

Green, Nancy S., Deepa Manwani, Kim Smith-Whitley, Banu Aygun, Abena Appiah-Kubi, and Arlene Smaldone. "Mental Health Assessment of Youth with Sickle Cell Disease and Their Primary Caretakers: Baseline Depression and COVID-19 Pandemic-Associated Psychosocial Stress in a Multi-Site Study." Blood 136, Supplement 1 (2020): 41–42. http://dx.doi.org/10.1182/blood-2020-140866.

Full text

Abstract:

Introduction: Youth with sickle cell disease (SCD) and their families are susceptible to stress and depression associated with chronic illness and social factors disproportionately affecting under-resourced U.S. communities. The COVID-19 pandemic has adversely impacted psychosocial and economic well-being, especially in some of these same communities. Our concurrent HABIT multi-site randomized trial aims to improve hydroxyurea adherence in youth with SCD ages 10-18 years through an intervention led by community health workers(NCT03462511). Subjects enrolled as youth-primary caretaker dyads; ad

APA, Harvard, Vancouver, ISO, and other styles

45

Bishop, Michael R., Richard Thomas T. Maziarz, Edmund K. Waller, et al. "Safety and Efficacy of Tisagenlecleucel Treatment in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (r/r DLBCL) and No Evidence of Active Disease Following Bridging Chemotherapy in the JULIET Trial." Blood 132, Supplement 1 (2018): 2958. http://dx.doi.org/10.1182/blood-2018-99-115094.

Full text

Abstract:

Abstract INTRODUCTION It is unknown whether chimeric antigen receptor (CAR)-T cells expand or provide clinical benefit in patients (pts) without detectable disease before infusion. JULIET (NCT02445248) is a single-arm, open-label, multicenter, global, phase 2 trial investigating tisagenlecleucel, an autologous anti-CD19 CAR-T cell therapy recently approved by the US Food and Drug Administration for treatment of adult pts with r/r DLBCL. Pts were enrolled in JULIET based on local assessment of measurable disease at screening. To control disease and stabilize pts during the period between aphere

APA, Harvard, Vancouver, ISO, and other styles

46

Lee, Juliet P., Lina Salam, Gamila Abdelhalim, et al. "Tobacco Use, Quitting, and Service Access for Northern California Arab Americans: A Participatory Study." Progress in Community Health Partnerships: Research, Education, and Action 17, no. 3 (2023): 379–92. http://dx.doi.org/10.1353/cpr.2023.a907969.

Full text

Abstract:

Abstract: Background: Cigarette smoking rates have decreased in the United States, particularly in California. Despite representing a large population in the United States and particularly in California, Arab Americans are not typically assessed in tobacco-related health studies. Disparately high smoking rates have been found in community samples of Arab Americans. In a formative participatory research study, we aimed to assess experiences with tobacco products and access to cessation and prevention services for Arab Americans who use commercial tobacco products. Methods: In partnership with a

APA, Harvard, Vancouver, ISO, and other styles

47

Wong, Raymond SM, James B. Bussel, Mansoor N. Saleh, et al. "Efficacy of Eltrombopag in Adult East Asian and Non-East Asian Patients with Chronic Immune Thrombocytopenia (cITP): Results from the Extend Study." Blood 128, no. 22 (2016): 4930. http://dx.doi.org/10.1182/blood.v128.22.4930.4930.

Full text

Abstract:

Abstract Introduction: Eltrombopag is an oral thrombopoietin receptor agonist, approved for the treatment of patients with cITP (persisting >12 months) aged ≥1 year, who are refractory to other treatments (eg corticosteroids, immunoglobulins). Pharmacokinetic studies of eltrombopag have demonstrated that patients of East Asian origin (eg Japanese, Chinese, Taiwanese and Korean) experience increased plasma exposure to eltrombopag compared to non-East Asian patients (predominantly Caucasian). As such, the recommended starting dose is 25 mg/day for East Asian patients, compared with 50 mg/day

APA, Harvard, Vancouver, ISO, and other styles

48

Papier, Joy. "Acknowledgements." Journal of Vocational, Adult and Continuing Education and Training 1, no. 1 (2018): v. http://dx.doi.org/10.14426/jovacet.v1i1.7.

Full text

Abstract:

The Journal of Vocational, Adult and Continuing Education and Training could not have become a reality without the commitment of a number of individuals and organisations who provided support at critical stages of its development.  We are grateful for the vision of the University of the Western Cape Faculty of Education, especially that of the former Dean of Education, Prof. Zubeida Desai, for her enthusiasm for this venture.  We thank the Education Policy Consortium (EPC) for its initial seed funding grant which enabled the scoping research and the journal development

APA, Harvard, Vancouver, ISO, and other styles

49

Raje, Noopur S., Omar Nadeem, Joseph Mikhael, et al. "Pilot Trial of the My Hematology Oncology Patient Experience (MyHOPE™) for Multiple Myeloma (MM) Digital Solution in Patients with MM." Blood 136, Supplement 1 (2020): 3–4. http://dx.doi.org/10.1182/blood-2020-141591.

Full text

Abstract:

Background: There is growing evidence to suggest that continuous monitoring and a proper use of patient-reported outcomes (PROs) in the clinical setting may improve patient care by facilitating doctor-patient communication, promoting individualized supportive care, and increasing patient satisfaction (Velikova, J Clin Oncol. 2004;22(4):714-24; Yang, Support Care Cancer. 2018 Jan;26(1):41-60). This may be of particular importance for patients with MM, a condition characterized by considerable heterogeneity in PROs at different timepoints within a patient's disease journey (TA King et al, Semin

APA, Harvard, Vancouver, ISO, and other styles

50

Wheat, Emily, Bryn M. Dunham, Whitney Tedeschi, et al. "Feasibility of Delivering Pediatric-to-Adult Transition Education during Annual Comprehensive Clinic Appointments and Patient-Reported Outcomes: A Quality Improvement Study." Blood 138, Supplement 1 (2021): 2993. http://dx.doi.org/10.1182/blood-2021-153090.

Full text

Abstract:

Abstract Individuals with bleeding disorder diagnoses require developmentally sensitive care across the lifespan, particularly as they gain knowledge and skills necessary to successfully tackle their illness-specific needs as independent adults (Breakey et al., 2010). The current study describes one phase of a larger quality improvement (QI) initiative aimed at improving transition from pediatric to adult care (TAC) at one US Hemophilia and Thrombosis Center (HTC). Our aim was to assess the feasibility of delivering transition specific education to youth-caregiver dyads during youth annual mul

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!