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Journal articles on the topic 'Zeaxanthin/ Lutein'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Chao, Shih-Chun, Tommaso Vagaggini, Chan-Wei Nien, Sheng-Chieh Huang, and Hung-Yu Lin. "Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways." Journal of Ophthalmology 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/152854.

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The effects of lutein and zeaxanthin on lipopolysaccharide- (LPS-) induced secretion of IL-8 by uveal melanocytes (UM) were tested in cultured human UM. MTT assay revealed that LPS (0.01–1 μg/mL) and lutein and zeaxanthin (1–10 μM) did not influence the cell viability of cultured UM. LPS caused a dose-dependent increase of secretion of IL-8 by cultured UM. Lutein and zeaxanthin did not affect the constitutive secretion of IL-8. However, lutein and zeaxanthin decreased LPS-induced secretion of IL-8 in cultured UM in a dose-dependent manner. LPS significantly increased NF-κB levels in cell nucle

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2

Wang, Litao, Weihang Lu, Jiali Li, et al. "Optimization of Ultrasonic-Assisted Extraction and Purification of Zeaxanthin and Lutein in Corn Gluten Meal." Molecules 24, no. 16 (2019): 2994. http://dx.doi.org/10.3390/molecules24162994.

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Zeaxanthin and lutein have a wide range of pharmacological applications. In this study, we conducted systematic experimental research to optimize antioxidant extraction based on detection, extraction, process amplification, and purification. An ultrasonic-assisted method was used to extract zeaxanthin and lutein with high efficiency from corn gluten meal. Firstly, the effects of solid-liquid ratio, extraction temperature, and ultrasonic extraction time on the extraction of zeaxanthin were investigated in single-factor experiments. The optimization extraction parameters of zeaxanthin and lutein

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3

Graydon, Ryan, Ruth E. Hogg, Usha Chakravarthy, Ian S. Young, and Jayne V. Woodside. "The effect of lutein- and zeaxanthin-rich foods v. supplements on macular pigment level and serological markers of endothelial activation, inflammation and oxidation: pilot studies in healthy volunteers." British Journal of Nutrition 108, no. 2 (2012): 334–42. http://dx.doi.org/10.1017/s0007114511005599.

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The aim of the present study was to compare the effect of lutein- and zeaxanthin-rich foods and supplements on macular pigment level (MPL) and serological markers of endothelial activation, inflammation and oxidation in healthy volunteers. We conducted two 8-week intervention studies. Study 1 (n 52) subjects were randomised to receive either carrot juice (a carotene-rich food) or spinach powder (a lutein- and zeaxanthin-rich food) for 8 weeks. Study 2 subjects (n 75) received supplements containing lutein and zeaxanthin, β-carotene, or placebo for 8 weeks in a randomised, double-blind, placebo

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4

Basmacıoğlu Malayoğlu, H., B. Aktaş, F. Karataş, and P. Özdemir. "Inclusion of Lutein and Zeaxanthin in Standard or Omega-3 Fatty Acids Enriched Laying Hens Diets: Effects on Performance, Egg Quality Parameters, Fatty Acid Composition and Individual Carotenoids Concentration of Egg Yolk." Journal of the Hellenic Veterinary Medical Society 75, no. 2 (2024): 7551–62. http://dx.doi.org/10.12681/jhvms.35240.

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The effects of lutein (L) and zeaxanthin (Z) inclusion to standard or omega-3 fatty acids enriched laying hens’ diets, on performance, egg quality parameters, fatty acids and individual carotenoids of egg yolk was investigated. The dietary treatments were designed as: standard (S) diet, 50 mg/kg L plus 50 mg/kg Z (S+L/Z (50+50)) or 100 mg/kg lutein plus 100 mg/kg zeaxanthin (S+L/Z (100+100)) added to S diet, Omega-3 fatty acids enriched (OM3) diet, 50 mg/kg lutein plus 50 mg/kg zeaxanthin (OM3+L/Z (50+50) or 100 mg/kg lutein plus 100 mg/kg zeaxanthin (OM3+L/Z (100+100)) added to OM3 diet. Hens

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Golubkina, N. A., G. A. Khimich, M. S. Antoshkina, U. D. Plotnikova, S. M. Nadezhkin, and I. B. Korottseva. "Peculiarities of pumpkin carotenoid composition ‘Konfetka’ variety, prospects of utilization." Vegetable crops of Russia, no. 1 (March 5, 2021): 111–16. http://dx.doi.org/10.18619/2072-9146-2021-1-111-116.

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Relevance. Pumpkin is one of the most important source of carotenoids for humans: β- and α-carotene, lutein and zeaxanthin playing a fundamental role in providing twilight and color vision accordingly.Results. Investigation of pumpkin carotenoid composition, Konfetka variety, revealed for the first time that this cultivar is the only one containing exclusively lutein in pulp with lutein and zeaxanthin in peel and lutein, zeaxanthin and β-carotene in placenta. Lutein concentration in pulp reached 11 mg/100 g, peel – 41.3/100 g, placenta – 51.2 mg/100 g. Zeaxanthin was absent in pulp and reached

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6

Li, Binxing, Evan W. George, Gregory T. Rognon, et al. "Imaging lutein and zeaxanthin in the human retina with confocal resonance Raman microscopy." Proceedings of the National Academy of Sciences 117, no. 22 (2020): 12352–58. http://dx.doi.org/10.1073/pnas.1922793117.

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Lutein and zeaxanthin are xanthophyll carotenoids that are highly concentrated in the human macula, where they protect the eye from oxidative damage and improve visual performance. Distinguishing lutein from zeaxanthin in images of the human retina in vivo or in donor eye tissues has been challenging because no available technology has been able to reliably differentiate between these two carotenoids, which differ only in the position of one C = C bond. Here, we report the differential distributions of lutein and zeaxanthin in human donor retinas mapped with confocal resonance Raman microscopy

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7

Baek, Jeonghun, Wei Meng Lim, and Lai Chun Wong. "Comparison of vegetable oils on the uptake of lutein and zeaxanthin by ARPE-19 cells." International Journal of Ophthalmology 16, no. 1 (2023): 40–46. http://dx.doi.org/10.18240/ijo.2023.01.06.

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AIM: To compare the effect of vegetable oils on the uptake of lutein and zeaxanthin by adult retinal pigment epithelial (ARPE)-19 cells in vitro. METHODS: ARPE-19 cells were cultured in Dulbecco’s Modified Eagle Medium-F-12 supplemented with 10% foetal bovine serum and 1% penicillin–streptomycin in a humidified 5% CO2 incubator maintained at 37℃. Cells were treated with 247 µmol/L lutein, 49 µmol/L zeaxanthin and 1% (v/v) of either coconut oil, corn oil, peanut oil, olive oil, sunflower oil, soybean oil, castor oil, or linseed oil for 48h. Lutein and zeaxanthin concentration in the cells were

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8

Loskutova, Ekaterina, Kajal Shah, Ian D. Flitcroft, et al. "Lutein and zeaxanthin: The possible contribution, mechanisms of action and implications of modern dietary intake for cognitive development in children." HRB Open Research 2 (April 26, 2019): 8. http://dx.doi.org/10.12688/hrbopenres.12903.1.

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Background:Studies suggest that lutein and zeaxanthin may be important for cognitive development in children, but a comprehensive evidence synthesis is lacking. The purpose of this evidence synthesis was to analyse the available data regarding the role of lutein and zeaxanthin for cognition in children and propose a theoretical basis for future studies.Methods:The PubMed, Scopus, the ISRCTN registry and Cochrane Library databases were searched for studies that evaluated the relationship between lutein and zeaxanthin and cognitive function in children. Reference list and ancestry searches were

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Różanowska, Małgorzata B., Barbara Czuba-Pelech, John T. Landrum, and Bartosz Różanowski. "Comparison of Antioxidant Properties of Dehydrolutein with Lutein and Zeaxanthin, and their Effects on Cultured Retinal Pigment Epithelial Cells." Antioxidants 10, no. 5 (2021): 753. http://dx.doi.org/10.3390/antiox10050753.

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Dehydrolutein accumulates in substantial concentrations in the retina. The aim of this study was to compare antioxidant properties of dehydrolutein with other retinal carotenoids, lutein, and zeaxanthin, and their effects on ARPE-19 cells. The time-resolved detection of characteristic singlet oxygen phosphorescence was used to compare the singlet oxygen quenching rate constants of dehydrolutein, lutein, and zeaxanthin. The effects of these carotenoids on photosensitized oxidation were tested in liposomes, where photo-oxidation was induced by light in the presence of photosensitizers, and monit

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10

Karppi, Jouni, Jari A. Laukkanen, and Sudhir Kurl. "Plasma lutein and zeaxanthin and the risk of age-related nuclear cataract among the elderly Finnish population." British Journal of Nutrition 108, no. 1 (2011): 148–54. http://dx.doi.org/10.1017/s0007114511005332.

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Oxidative stress plays an important role in cataractogenesis. Previous studies have shown that long-term dietary intake of antioxidants (lutein and zeaxanthin) may decrease the risk of age-related cataracts. The aim of the present study was to examine whether plasma concentrations of lutein and zeaxanthin are related to age-related nuclear cataract in the elderly population. Subjects were participants in the Kuopio Ischaemic Heart Disease Risk Factor Study and they were classified into tertiles according to plasma concentrations of lutein and zeaxanthin. The association of plasma lutein and ze

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11

Nesterenko, Sergey, and Kenneth C. Sink. "Carotenoid Profiles of Potato Breeding Lines and Selected Cultivars." HortScience 38, no. 6 (2003): 1173–77. http://dx.doi.org/10.21273/hortsci.38.6.1173.

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Lutein and zeaxanthin are becoming established as carotenoids beneficial for protection against common age-associated eye diseases. Thus, 15 potato (Solanum tuberosum subsp. tuberosum L.) breeding lines, cultivars Atlantic, Spunta, and Yukon Gold; and orange flesh OR-4 were surveyed for carotenoid profiles. Seven carotenoids, including violaxanthin, neoaxanthin, antheraxanthin, lutein, zeaxanthin, β-cryptoaxanthin, and β-carotene, were identified in the 19 genotypes. Violaxanthin and lutein were the prominent carotenoids detected in all genotypes studied. Neoaxanthin and antheraxanthin were fo

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12

Skřivanová, V., M. Englmaierová, M. Bendová, and M. Skřivan. "Effect of the source and level of carotenoids in diets on their retention in eggs." Czech Journal of Animal Science 62, No. 8 (2017): 323–30. http://dx.doi.org/10.17221/17/2017-cjas.

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The lutein and zeaxanthin deposition in egg yolks of hens was evaluated. The effects of various levels of extracts from Mexican marigold flowers in hen diets were compared in Experiments 1 (from 0 to 350 mg/kg) and 2 (from 0 to 950 mg/kg). In Experiment 3, the sources of carotenoids such as lutein (250 mg/kg) and Chlorella (12.5 g/kg) were examined. All three experiments were conducted using brown egg layers housed in enriched cages. The lutein concentrations in yolks were increased (P &lt; 0.05) from 0.141 to 0.232 mg/60 g of egg (Experiment 1) and from 0.096 to 0.283 mg/60 g of egg (Expe

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13

Thurnham, David I., Aurélie Trémel, and Alan N. Howard. "A supplementation study in human subjects with a combination ofmeso-zeaxanthin, (3R,3′R)-zeaxanthin and (3R,3′R,6′R)-lutein." British Journal of Nutrition 100, no. 6 (2008): 1307–14. http://dx.doi.org/10.1017/s0007114508971336.

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We measured the blood uptake ofmeso-zeaxanthin (MZ) from a mixture of macular pigments since its bioavailability in man has not been studied. Volunteers (ten men and nine women) were recruited and received one capsule of Lutein Plus®/d. Blood was taken at baseline, day 10 and day 22. One capsule contained 10·8 mg lutein, 1·2 mg (3R,3′R)-zeaxanthin and 8·0 mg MZ. Plasma lutein and total zeaxanthin concentrations were quantified using isocratic liquid chromatography and the eluting xanthophyll fractions were collected and re-chromatographed on a chiral column to assess the proportion of MZ. Plas

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14

Lai, Jun S., Vaishnavi O. Veetil, Carla Lanca, et al. "Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study." Nutrients 12, no. 2 (2020): 274. http://dx.doi.org/10.3390/nu12020274.

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Lutein and zeaxanthin play important roles in visual functions, but their influence on early visual development is unclear. We related maternal lutein and zeaxanthin concentrations during pregnancy to offspring visual acuity (VA) in 471 mother–child pairs from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. Maternal concentrations of plasma lutein and zeaxanthin were determined at delivery. We measured uncorrected distance of VA in 3-year old children using a LEA Symbols chart; readings were converted to the logarithm of Minimum Angle of Resolution (logMAR), with >0.3 l

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15

Mrowicka, Małgorzata, Jerzy Mrowicki, Ewa Kucharska, and Ireneusz Majsterek. "Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration—Neurodegenerative Disease." Nutrients 14, no. 4 (2022): 827. http://dx.doi.org/10.3390/nu14040827.

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Lutein and zeaxanthin belong to the xanthophyll family of carotenoids, which are pigments produced by plants. Structurally, they are very similar, differing only slightly in the arrangement of atoms. Key sources of these carotenoids include kale, savoy cabbage, spinach, broccoli, peas, parsley, corn, and egg yolks. The recommended daily intake of lutein is approximately 10.0 mg and that of zeaxanthin is 2 mg. Lutein intake in adults varies, with average intakes being 1–2 mg/day. Due to the lack of synthesis of consumption of these compounds in humans, these substances are extremely important f

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16

Abdel-Aal, El-Sayed M., Iwona Rabalski, Christine Carey, and Tamer H. Gamel. "Bioaccessibility and Cellular Uptake of Lutein, Zeaxanthin and Ferulic Acid from Muffins and Breads Made from Hairless Canary Seed, Wheat and Corn Blends." Foods 12, no. 6 (2023): 1307. http://dx.doi.org/10.3390/foods12061307.

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Using a simulated gastrointestinal digestion model combined with a Caco-2 cell model, this study aims to assess the bioaccessibility and cellular uptake of dietary lutein, zeaxanthin, and ferulic acid from muffins and bread prepared from blends of hairless canary seed (HCS), wheat, and corn. Residual digestive enzymes damaged the Caco-2 monolayer and necessitated the requirements for the additional clean-up of the digesta. Several digesta cleanup treatments were examined, and the C18 column, along with AEBSF inhibitor, was selected as the most effective treatment. However, the cleanup treatmen

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Warfield, John R., and Brandon J. Lewis. "Validation of an HPLC Method for the Simultaneous Determination of trans-Lutein, (3R,3′R)-trans-Zeaxanthin, and (3R,3′S)-trans-Zeaxanthin." Journal of AOAC INTERNATIONAL 96, no. 3 (2013): 630–34. http://dx.doi.org/10.5740/jaoacint.12-184.

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Abstract trans-Lutein, (3R,3′R)-trans-zeaxanthin, and (3R,3′S, meso)-trans-zeaxanthin are carotenoid isomers found in the human eye. Trans-lutein and trans-zeaxanthin can be separated under NP chromatographic conditions; however, (3R,3′R)-trans-zeaxanthin and (3R,3′S)-trans- zeaxanthin coelute and require chiral separation techniques. The validation of an HPLC analytical method for the simultaneous determination of trans-lutein, (3R,3′R)-trans-zeaxanthin, and (3R,3′S)-trans- zeaxanthin is described. The method uses a hexanes and 2-propanol gradient on a Daicel AD-H chiral column to separate th

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Aguillón-Páez, Y. J., and G. J. Díaz. "Lutein and zeaxanthin content in corn imported from three countries of the American continent and in corn cultivated in Colombian territory." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 75, no. 3 (2023): 500–510. http://dx.doi.org/10.1590/1678-4162-12786.

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ABSTRACT Lutein and zeaxanthin are the major xanthophyll pigments found in corn kernels. These pigments provide the orange-red color of the broiler chicken skin and of the egg yolk. Therefore, knowing the corn xanthophyll content is important for the poultry feed producer. The objective of this study was to determine the lutein and the zeaxanthin content in corn cultivated in Colombia and in corn imported to Colombia from the United States, Argentina, and Brazil. Large differences in total lutein plus zeaxanthin content were found among the corn samples analyzed, with the highest mean level fo

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Bobroff, Linda B. "Carotenoids and Eye Health." EDIS 2017, no. 2 (2017): 3. http://dx.doi.org/10.32473/edis-fy1217-2016.

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A diet rich in colorful fruits and vegetables provides a variety of nutrients as well as phytochemicals that can promote health. Lutein and zeaxanthin are two non-provitamin A carotenoids that may be protective against AMD, the leading cause of permanent central vision loss in older adults. This 3-page fact sheet provides an overview of carotenoids, AMD, lutein, zeaxanthin, risk factors for AMD, and good sources of lutein and zeaxanthin. Written by Linda B. Bobroff, and published by the UF Department of Family, Youth and Community Sciences, revised October 2016.

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Widomska, Justyna, Wieslaw I. Gruszecki, and Witold K. Subczynski. "Factors Differentiating the Antioxidant Activity of Macular Xanthophylls in the Human Eye Retina." Antioxidants 10, no. 4 (2021): 601. http://dx.doi.org/10.3390/antiox10040601.

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Macular xanthophylls, which are absorbed from the human diet, accumulate in high concentrations in the human retina, where they efficiently protect against oxidative stress that may lead to retinal damage. In addition, macular xanthophylls are uniquely spatially distributed in the retina. The zeaxanthin concentration (including the lutein metabolite meso-zeaxanthin) is ~9-fold greater than lutein concentration in the central fovea. These numbers do not correlate at all with the dietary intake of xanthophylls, for which there is a dietary zeaxanthin-to-lutein molar ratio of 1:12 to 1:5. The uni

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Aguillón-Páez, Yandy J., and Gonzalo J. Díaz. "Lutein and Zeaxanthin Content in 21 Plant Species from a Very Humid Premontane Forest in Colombia Palatable for Free-Range Laying Hens." Plants 12, no. 19 (2023): 3484. http://dx.doi.org/10.3390/plants12193484.

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Xanthophylls, such as lutein and zeaxanthin, have several functions in both plants and humans, including detoxification of oxidants (reactive oxygen species (ROS) and other radicals), maintenance of the structural and functional integrity of biological membranes, and photoprotection from intense light damage. The objective of the present study was to investigate the lutein and zeaxanthin content of 21 species of plants from a very humid premontane forest in Colombia during both dry and rainy seasons. The plants were selected based on being voluntarily eaten by laying hens under free-range cond

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Davey, Pinakin Gunvant, Richard B. Rosen, and Dennis L. Gierhart. "Macular Pigment Reflectometry: Developing Clinical Protocols, Comparison with Heterochromatic Flicker Photometry and Individual Carotenoid Levels." Nutrients 13, no. 8 (2021): 2553. http://dx.doi.org/10.3390/nu13082553.

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The study was designed to: (1) Analyze and create protocols of obtaining measurements using the Macular Pigment Reflectometry (MPR). (2) To assess the agreement of MPOD measurements obtained using the heterochromatic flicker photometry (MPS II) and MPR. (3) To obtain the lutein and zeaxanthin optical density obtained using the MPR in the central one-degree of the macula. The measurements were performed using the MPR and heterochromatic flicker photometry. The MPR measurements were performed twice without pupillary dilation and twice following pupillary dilation. The MPR measurements were perfo

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Li, Nenghui, Jing Li, Dongxia Ding, et al. "Optimum Parameters for Extracting Three Kinds of Carotenoids from Pepper Leaves by Response Surface Methodology." Separations 8, no. 9 (2021): 134. http://dx.doi.org/10.3390/separations8090134.

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To determine the optimum parameters for extracting three carotenoids including zeaxanthin, lutein epoxide, and violaxanthin from pepper leaves by response surface methodology (RSM), a solvent of acetone and ethyl acetate (1:2) was used to extract carotenoids with four independent factors: ultrasound time (20–60 min); ratio of sample to solvent (1:12–1:4); saponification time (10–50 min); and concentration of saponification solution (KOH–methanol) (10–30%). A second-order polynomial model produced a satisfactory fitting of the experimental data with regard to zeaxanthin (R2 = 75.95%, p < 0.0

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Vishwanathan, Rohini, Martha Neuringer, D. Max Snodderly, Wolfgang Schalch, and Elizabeth J. Johnson. "Macular lutein and zeaxanthin are related to brain lutein and zeaxanthin in primates." Nutritional Neuroscience 16, no. 1 (2013): 21–29. http://dx.doi.org/10.1179/1476830512y.0000000024.

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Schnebelen-Berthier, Coralie, Niyazi Acar, Emilie Simon, et al. "The ALGOVUE Clinical Trial: Effects of the Daily Consumption of Eggs Enriched with Lutein and Docosahexaenoic Acid on Plasma Composition and Macular Pigment Optical Density." Nutrients 13, no. 10 (2021): 3347. http://dx.doi.org/10.3390/nu13103347.

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Background. Carotenoids and docosahexaenoic acid (DHA) were identified as essential components for eye health and are both naturally present in eggs. Objective. We aimed to evaluate the effect of the daily consumption of two eggs enriched with lutein/zeaxanthin and DHA on macular pigment optical density (MPOD) and on circulating xanthophyll and fatty acid concentrations in healthy participants. Methods. Ninety-nine healthy volunteers consumed either two standard eggs or two enriched eggs per day for 4 months. MPOD was measured at baseline (V0) and at follow-up (V4) using a modified confocal sc

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Huang, Yang-Mu, Hong-Liang Dou, Fei-Fei Huang, Xian-Rong Xu, Zhi-Yong Zou, and Xiao-Ming Lin. "Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigmentation, and Visual Performance in Patients with Early Age-Related Macular Degeneration." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/564738.

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Purpose. To compare the 2-year effect of multiple doses of lutein/zeaxanthin on serum, macular pigmentation, and visual performance on patients with early age-related macular degeneration (AMD).Methods. In this randomized, double-blinded, and placebo-controlled trial, 112 early AMD patients randomly received either 10 mg lutein, 20 mg lutein, a combination of lutein (10 mg) and zeaxanthin (10 mg), or placebo daily for 2 years. Serum concentration of lutein/zeaxanthin, macular pigment optical density (MPOD), visual functions including best-spectacle corrected visual acuity (BCVA), contrast sens

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Hemalatha, N., J. Naveen та V. Baskaran. "Medicinal Plants as Sources of Retina Protective Carotenoids (Lutein, β-carotene) and their Radical Scavenging Property". Indian Journal of Nutrition and Dietetics 56, № 4 (2019): 365. http://dx.doi.org/10.21048/ijnd.2019.56.4.23709.

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The study assesses the Retinol Activity Equivalent (RAE), lutein and zeaxanthin, total polyphenols and antioxidant potential of medicinal plants. Amongst plants, the highest levels (mg/100 g dry weight) of β-carotene and lutein + zeaxanthin were detected in Centella asiatica, (197.5) and V. aroma (894.6). Interestingly, V. aroma (871, 85), Acacia concinna (587, 65), Centella asiatica (404, 198), Oxalis corniculata (501, 196) and Tinospara cordifolia (417, 120) are rich in β-carotene and lutein + zeaxanthin. The RAE (RAE/100 g dry wt.) is higher in A. citratus (9.5), B. diffusa (13.0), C. asiat

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Jiao, Yan, Dajing Li, Ying Chang, and Yadong Xiao. "Effect of Freeze-Thaw Pretreatment on Extraction Yield and Antioxidant Bioactivity of Corn Carotenoids (Lutein and Zeaxanthin)." Journal of Food Quality 2018 (November 21, 2018): 1–8. http://dx.doi.org/10.1155/2018/9843503.

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As a green and low-energy pretreatment method, the effect of freeze-thaw (FT) pretreatment on extraction yield and antioxidant bioactivity of carotenoids of the corn gluten meal (CGM) were evaluated in this study. The CGM particles ruptured in FT treatment due to the repeated damage caused by FT to CGM particles. The carotenoid compounds of pretreated CGM were lutein, zeaxanthin, β-carotene, and cryptoxanthin. Among them, the major carotenoids are lutein and zeaxanthin. The optimized FT pretreatment conditions included freezing temperature of −20°C, moisture content of 100%, and 2 cycles. An i

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Xue, Chunyan, Richard Rosen, Adrienne Jordan, and Dan-Ning Hu. "Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies?" Journal of Ophthalmology 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/523027.

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Zeaxanthin and lutein are two carotenoid pigments that concentrated in the retina, especially in the macula. The effects of lutein and zeaxanthin on the prevention and treatment of various eye diseases, including age-related macular degeneration, diabetic retinopathy and cataract, ischemic/hypoxia induced retinopathy, light damage of the retina, retinitis pigmentosa, retinal detachment, and uveitis, have been studied in different experimental animal models. In these animal models, lutein and zeaxanthin have been reported to have beneficial effects in protecting ocular tissues and cells (especi

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Yan, Bo, Min-Shan Lu, Lian Wang, et al. "Specific serum carotenoids are inversely associated with breast cancer risk among Chinese women: a case–control study." British Journal of Nutrition 115, no. 1 (2015): 129–37. http://dx.doi.org/10.1017/s000711451500416x.

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AbstractPrevious epidemiological studies have revealed the anti-cancer effect of dietary circulating carotenoids. However, the protective role of specific individual circulating carotenoids has not been elucidated. The purpose of this study was to examine whether serum carotenoids, includingα-carotene,β-carotene,β-cryptoxanthin, lycopene and lutein/zeaxanthin, could lower the risk for breast cancer among Chinese women. A total of 521 women with breast cancer and age-matched controls (5-year interval) were selected from three teaching hospitals in Guangzhou, China. Concentrations ofα-carotene,β

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Merle, Bénédicte M. J., Audrey Cougnard-Grégoire, Jean-François Korobelnik, et al. "Plasma Lutein, a Nutritional Biomarker for Development of Advanced Age-Related Macular Degeneration: The Alienor Study." Nutrients 13, no. 6 (2021): 2047. http://dx.doi.org/10.3390/nu13062047.

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Lutein and zeaxanthin may lower the risk of age-related macular degeneration (AMD). We evaluated the associations of plasma lutein and zeaxanthin with the incidence of advanced AMD in the Alienor study (Antioxydants Lipides Essentiels Nutrition et Maladies Oculaires). Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006–2008). The present study included 609 participants with complete ophthalmologic and plasma carotenoids data. Examinations were performed every two years over an eight-year period (2006 to 2017)

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Widomska, Justyna, John Paul SanGiovanni, and Witold K. Subczynski. "Why Is Zeaxanthin the Most Concentrated Xanthophyll in the Central Fovea?" Nutrients 12, no. 5 (2020): 1333. http://dx.doi.org/10.3390/nu12051333.

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Diet-based xanthophylls (zeaxanthin and lutein) are conditionally essential polar carotenoids preferentially accreted in high concentrations (1 mM) to the central retina, where they have the capacity to impart unique physiologically significant biophysical biochemical properties implicated in cell function, rescue, and survival. Macular xanthophylls interact with membrane-bound proteins and lipids to absorb/attenuate light energy, modulate oxidative stress and redox balance, and influence signal transduction cascades implicated in the pathophysiology of age-related macular degeneration. There

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Grudzinski, Wojciech, Rafal Luchowski, Jan Ostrowski, et al. "Physiological Significance of the Heterogeneous Distribution of Zeaxanthin and Lutein in the Retina of the Human Eye." International Journal of Molecular Sciences 24, no. 13 (2023): 10702. http://dx.doi.org/10.3390/ijms241310702.

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Zeaxanthin and lutein are xanthophyll pigments present in the human retina and particularly concentrated in its center referred to as the yellow spot (macula lutea). The fact that zeaxanthin, including its isomer meso-zeaxanthin, is concentrated in the central part of the retina, in contrast to lutein also present in the peripheral regions, raises questions about the possible physiological significance of such a heterogeneous distribution of macular xanthophylls. Here, we attempt to address this problem using resonance Raman spectroscopy and confocal imaging, with different laser lines selecte

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Scripsema, Nicole K., Dan-Ning Hu, and Richard B. Rosen. "Lutein, Zeaxanthin, andmeso-Zeaxanthin in the Clinical Management of Eye Disease." Journal of Ophthalmology 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/865179.

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Lutein, zeaxanthin, andmeso-zeaxanthin are xanthophyll carotenoids found within the retina and throughout the visual system. The retina is one of the most metabolically active tissues in the body. The highest concentration of xanthophylls is found within the retina, and this selective presence has generated many theories regarding their role in supporting retinal function. Subsequently, the effect of xanthophylls in the prevention and treatment of various eye diseases has been examined through epidemiological studies, animal studies, and clinical trials. This paper attempts to review the epide

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Thurnham, David I. "Macular zeaxanthins and lutein – a review of dietary sources and bioavailability and some relationships with macular pigment optical density and age-related macular disease." Nutrition Research Reviews 20, no. 2 (2007): 163–79. http://dx.doi.org/10.1017/s0954422407842235.

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The retina is unique in the human body in containing three xanthophyll carotenoids; 3R,3′R-zeaxanthin, meso-zeaxanthin (MZ) and lutein. Humans consume 1 to 3 mg lutein per d and the lutein:zeaxanthin ratio in the diet is about 5:1.Xanthophyll pigments occur widely in vegetables and fruits but MZ is found in only a few foods such as the shrimp carapace and fish skin. In spite of the amounts of the different xanthophylls in the diet, zeaxanthin and MZ occur in approximately equal amounts in the eye, and their combined concentration can exceed that of lutein. In the present review the bioavailabl

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Zheng, Jingyuan, Brian V. Hong, Joanne K. Agus, et al. "Lutein and Zeaxanthin Enhance, Whereas Oxidation, Fructosylation, and Low pH Damage High-Density Lipoprotein Biological Functionality." Antioxidants 13, no. 5 (2024): 616. http://dx.doi.org/10.3390/antiox13050616.

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High-density lipoproteins (HDLs) are key regulators of cellular cholesterol homeostasis but are functionally altered in many chronic diseases. The factors that cause HDL functional loss in chronic disease are not fully understood. It is also unknown what roles antioxidant carotenoids play in protecting HDL against functional loss. The aim of this study was to measure how various disease-associated chemical factors including exposure to (1) Cu2+ ions, (2) hypochlorous acid (HOCL), (3) hydrogen peroxide (H2O2), (4) sialidase, (5) glycosidase, (6) high glucose, (7) high fructose, and (8) acidic p

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Roberts, Richard L. "Lutein, Zeaxanthin, and Skin Health." American Journal of Lifestyle Medicine 7, no. 3 (2013): 182–85. http://dx.doi.org/10.1177/1559827613477827.

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Ma, Le, Hong-Liang Dou, Yi-Qun Wu, et al. "Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis." British Journal of Nutrition 107, no. 3 (2011): 350–59. http://dx.doi.org/10.1017/s0007114511004260.

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Lutein and zeaxanthin are thought to decrease the incidence of age-related macular degeneration (AMD); however, findings have been inconsistent. We conducted a systematic literature review and meta-analysis to evaluate the relationship between dietary intake of lutein and zeaxanthin and AMD risk. Relevant studies were identified by searching five databases up to April 2010. Reference lists of articles were retrieved, and experts were contacted. Literature search, data extraction and study quality assessment were performed independently by two reviewers and results were pooled quantitatively us

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Agarwal, Rimjhim, Hung T. Hong, Alice Hayward, Stephen Harper, Neena Mitter, and Tim J. O’Hare. "Carotenoid Profiling of Orange-Coloured Capsicums: In Search of High-Zeaxanthin Varieties for Eye Health." Proceedings 70, no. 1 (2020): 84. http://dx.doi.org/10.3390/foods_2020-07717.

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Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries, such as Australia. Lutein and zeaxanthin are the only two carotenoids found in the macular region of the eye. Studies have shown that an intake of 10 mg and 2 mg per day of lutein and zeaxanthin, respectively, can reduce the rate of progression of AMD. The supply of these carotenoids can only be met through dietary sources or supplements, as these compounds cannot be synthesised by humans. Although lutein is relatively abundant in dietary sources, zeaxanthin has limited sources. In this study, eigh

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Bhushan Anilkumar Khajindar, Vishakha S. Shingote, Kiran K. Shinde, Rutuja Vijay Chavan, Vishal Sopan Tekude, and Snehal Kailas Bhand. "Exploring the role of lutein in eye health." World Journal of Biology Pharmacy and Health Sciences 20, no. 2 (2024): 725–33. https://doi.org/10.30574/wjbphs.2024.20.2.0951.

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Lutein, a xanthophyll carotenoid, has gained significant attention for its potent antioxidant and anti-inflammatory properties, particularly in protecting eye health. Derived from dark green leafy vegetables like spinach and kale, lutein is known for its ability to neutralize harmful free radicals and reduce blue light-induced phototoxic damage in the retina. Research has demonstrated that lutein, through dietary intake, accumulates in the macula, a critical part of the retina, where it, along with zeaxanthin and meso-zeaxanthin, forms the macular pigment, essential for visual function. Studie

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Tudor, Cristina, and Adela Pintea. "A Brief Overview of Dietary Zeaxanthin Occurrence and Bioaccessibility." Molecules 25, no. 18 (2020): 4067. http://dx.doi.org/10.3390/molecules25184067.

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As it exhibits no provitamin A activity, the dietary intake of zeaxanthin is not considered essential. However, its contribution to ocular health has long been acknowledged. Numerous publications emphasize the importance of zeaxanthin alongside lutein in ocular diseases such as cataracts and age-related macular degeneration which constitute an important health concern, especially among the elderly. Considering that the average dietary ratio of lutein to zeaxanthin favors the first, more bioaccessible food sources of zeaxanthin that can hinder the development and progression of the above-mentio

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Roberts, Joan E., and Jessica Dennison. "The Photobiology of Lutein and Zeaxanthin in the Eye." Journal of Ophthalmology 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/687173.

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Lutein and zeaxanthin are antioxidants found in the human retina and macula. Recent clinical trials have determined that age- and diet-related loss of lutein and zeaxanthin enhances phototoxic damage to the human eye and that supplementation of these carotenoids has a protective effect against photoinduced damage to the lens and the retina. Two of the major mechanisms of protection offered by lutein and zeaxanthin against age-related blue light damage are the quenching of singlet oxygen and other reactive oxygen species and the absorption of blue light. Determining the specific reactive interm

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N'soukpoé-Kossi, C. N., and R. M. Leblanc. "Absorption and photoacoustic spectroscopies of lutein and zeaxanthin Langmuir–Blodgett films in connection with the Haidinger's brushes." Canadian Journal of Chemistry 66, no. 6 (1988): 1459–66. http://dx.doi.org/10.1139/v88-235.

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The molecular state of a single monolayer of lutein, zeaxanthin, and of a mixture of lutein and L-α-phosphatidylcholine-β-oleoyl-γ-stearoyl has been investigated using absorption and photoacoustic spectroscopies. Both methods, confirmatively, reveal that the two carotenoids are mostly in a monomer state coexisting with carotenoid crystals. We observe that the absorption as well as the photoacoustic bands are red-shifted relative to the bands in solution. The absorption bands are found to peak at mean values of 440.0, 464.8, and 503.8 ± 0.5 nm for lutein, and at 452.7, 475.9, and 513.7 ± 0.5 nm

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Korolev, Aleksei, Ekaterina Kirpichenkova, Elena Nikitenko, et al. "Consumption dietary sources of lycopene, lutein, and zeaxanthin among young adults living in megapolis." Potravinarstvo Slovak Journal of Food Sciences 15 (September 27, 2021): 917–25. http://dx.doi.org/10.5219/1633.

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Carotenoids are natural antioxidants, affecting apoptosis, absorbing active forms of oxygen, and improving visual performance through their blue light filtering capabilities. Lutein and zeaxanthin are carotenoids of the macular pigment that play a significant role in protecting against age-related macular degeneration (AMD), cataracts, and diabetic retinopathy. We analyzed the dietary sources of lycopene, lutein, and zeaxanthin of young adults living in a megapolis. We analyzed 431 food frequency questionnaires and used two different criteria for comparison: age (groups A1 and A2) and season (

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Widomska, Justyna, Witold K. Subczynski, Renata Welc-Stanowska, and Rafal Luchowski. "An Overview of Lutein in the Lipid Membrane." International Journal of Molecular Sciences 24, no. 16 (2023): 12948. http://dx.doi.org/10.3390/ijms241612948.

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Lutein, zeaxanthin, and meso-zeaxanthin (a steroisomer of zeaxanthin) are macular pigments. They modify the physical properties of the lipid bilayers in a manner similar to cholesterol. It is not clear if these pigments are directly present in the lipid phase of the membranes, or if they form complexes with specific membrane proteins that retain them in high amounts in the correct place in the retina. The high content of macular pigments in the Henle fiber layer indicates that a portion of the lutein and zeaxanthin should not only be bound to the specific proteins but also directly dissolved i

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Gruszecki, Wieslaw I., Agnieszka Sujak, Kazimierz Strzalka, Alfons Radunz, and Georg H. Schmid. "Organisation of Xanthophyll-Lipid Membranes Studied by Means of Specific Pigment Antisera, Spectrophotometry and Monomolecular Layer Technique Lutein versus Zeaxanthin." Zeitschrift für Naturforschung C 54, no. 7-8 (1999): 517–25. http://dx.doi.org/10.1515/znc-1999-7-810.

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Abstract The structure of the xanthophyll pigments lutein and zeaxanthin differs in the position of one double bond and refers to one of the ionon rings. Specific antibodies to zeaxanthin were used to analyse the localisation and orientation of these two xanthophyll pigments in lipid membranes formed with egg yolk lecithin. Bimolecular and monomolecular layers were used. Antibody-antigen interaction was demonstrated and analysed by the bathochromic shift of the absorption spectra of both pigments and by the increase of light-scattering of the pig- mented liposome suspension. It appeared that t

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Kim, Da-Sol, Suna Kang, Na-Rang Moon, Bae-Keun Shin та Sunmin Park. "Zeaxanthin and Lutein Ameliorate Alzheimer’s Disease-like Pathology: Modulation of Insulin Resistance, Neuroinflammation, and Acetylcholinesterase Activity in an Amyloid-β Rat Model". International Journal of Molecular Sciences 25, № 18 (2024): 9828. http://dx.doi.org/10.3390/ijms25189828.

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Alzheimer’s disease (AD) is characterized by impaired insulin/insulin-like growth factor-1 signaling in the hippocampus. Zeaxanthin and lutein, known for their antioxidant and anti-inflammatory properties, have been reported to protect against brain damage and cognitive decline. However, their mechanisms related to insulin signaling in AD remain unclear. This study investigated the efficacy and mechanisms of zeaxanthin, lutein, and resveratrol in modulating an AD-like pathology in an amyloid-β rat model. Rats were administered hippocampal infusions of 3.6 nmol/day amyloid-β (Aβ)(25-35) for 14

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Czeczuga, Bazyli. "Characteristic carotenoids in some phytobenthos species in the coastal area of the Adriatic Sea." Acta Societatis Botanicorum Poloniae 55, no. 4 (2014): 601–9. http://dx.doi.org/10.5586/asbp.1986.049.

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The author investigated the presence of various carotcnoids in some phytobenthos species (20 species representative of <em>Chlorophytn, Phaeophyta</em> and <em>Rhodophyta</em>) from the coast of the Adriatic Sea. The presence of following carotenoids has been determined 1) in <em>Chlorophyta</em> lycopene, α-, β-, γ- , ε-carotene, β-cryptoxanthin, lutein, lutein epoxide, zeaxanthin, antheraxanthin, neoxanthin, violaxanthin, siphonein and astaxanthin esier; 2) in <em>Phorophyta</em>: α-, β-, γ- , ε- carotene, zeaxanthin, antheraxanthin, diataxanth

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Griesbach, R. J., and L. Batdorf. "Flower Pigments within Hemerocallis fulva L. fm. fulva, fm. rosea, and fm. disticha." HortScience 30, no. 2 (1995): 353–54. http://dx.doi.org/10.21273/hortsci.30.2.353.

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Various forms of Hemerocallis fulva differed in their relative anthocyanin: carotenoid ratios and the type of anthocyanin present. Hemerocallis fulva fm. fulva contained a single anthocyanin (cyanidin-3-rutinoside) and two carotenoids (zeaxanthin and lutein). Hemerocallis fulva fm. rosea contained a single anthocyanin (cyanidin-3-rutinoside) and traces of carotenoids. Hemerocallis fulva fm. disticha contained a single anthocyanin (delphinidin-3-rutinoside) and two carotenoids (zeaxanthin and lutein).

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Berendschot, Tos T. J. M., Jogchum Plat, Ariënne de Jong, and Ronald P. Mensink. "Long-term plant stanol and sterol ester-enriched functional food consumption, serum lutein/zeaxanthin concentration and macular pigment optical density." British Journal of Nutrition 101, no. 11 (2008): 1607–10. http://dx.doi.org/10.1017/s0007114508111448.

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Observational epidemiological studies have shown that low carotenoid intake and/or low carotenoid blood levels increase the risk of degenerative diseases like age-related macular degeneration. Functional foods enriched with plant sterol or stanol esters may lower serum concentrations of fat-soluble carotenoids. Theoretically, as a result the macular pigment optical density (MPOD), a marker for eye health, may change. We carried out a double-blind placebo-controlled human intervention trial with a duration of 18 months to evaluate the possible effects of plant stanol and sterol esters on serum

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