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Academic literature on the topic 'Zebrafisch'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Zebrafisch"

1

Kiess, W., A. Körner, and K. Landgraf. "Der Zebrafisch als in vivo-Modellsystem für Adipositas und assoziierte Erkrankungen." Adipositas - Ursachen, Folgeerkrankungen, Therapie 12, no. 04 (December 2018): 198–203. http://dx.doi.org/10.1055/s-0038-1676678.

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ZusammenfassungViele Erkenntnisse über Mechanismen, die für die Entstehung von Adipositas, und den damit einhergehenden Adipositas-assoziierten Erkrankungen, relevant sind, sind mit Hilfe der Modellorganismen Maus oder Ratte erarbeitet worden. In den letzten Jahren hat sich der Zebrafisch als weiteres, sehr geeignetes in-vivo-Modellsystem etabliert, da er verschiedene Vorteile gegenüber Maus und Ratte und anderen Modellorganismen aufweist. Zudem sind wesentliche Aspekte der Regulation des Energiemetabolismus, welche bei der Entstehung von Adipositas und Adipositas-assoziierten Folgeerkrankungen beim Menschen eine Rolle spielen, im Zebrafisch konserviert. Dies beinhaltet unter anderem Mechanismen der zentralen Regulation des Sättigungsgefühls, der Fettzellentwicklung, der ernährungsbedingten Anhäufung von Fettgewebe sowie der Körperfettverteilung. Aufgrund dessen stellt der Zebrafisch ein geeignetes in vivo-Modellsystem für die Untersuchung von Prozessen dar, welche in die Entstehung von Adipositas und deren Folgeerkrankungen involviert sind.

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Westhoff, J. H., and B. Tönshoff. "Nephronneogenese durch renale Progenitorzellen im adulten Zebrafisch." Der Nephrologe 6, no. 5 (August 31, 2011): 435–36. http://dx.doi.org/10.1007/s11560-011-0553-3.

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Schredelseker, Johann, and Gerhard Krumschnabel. "Der Zebrafisch als vielseitiges Modellsystem. Vom Zierfisch zum Forschungsobjekt." Biologie in unserer Zeit 39, no. 6 (December 2009): 389–97. http://dx.doi.org/10.1002/biuz.200910406.

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Norton, William H. J., and Laure Bally-Cuif. "Die Zebrafisch fgfr1a-Mutante zeigt eine genetische Basis der Aggression." BIOspektrum 18, no. 1 (February 2012): 46–48. http://dx.doi.org/10.1007/s12268-012-0143-6.

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Jörgens, K., K. Schäker, and J. Kroll. "Der Modellorganismus Zebrafisch in der biomedizinischen Grundlagenforschung: Anwendungen und Perspektiven in der vaskulären Biologie und Medizin." DMW - Deutsche Medizinische Wochenschrift 136, no. 37 (September 6, 2011): 1865–68. http://dx.doi.org/10.1055/s-0031-1286357.

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Konantz, Martina, Martijn H. Brugman, In-Hyun Park, George Q. Daley, Christiane Nuesslein-Volhard, Christopher Baum, and Claudia Lengerke. "The Zebrafish Homologue of the Murine Ecotropic Viral Integration Site-1 (. Evi-1) gene Regulates Zebrafish Embryonic Blood Development." Blood 114, no. 22 (November 20, 2009): 1461. http://dx.doi.org/10.1182/blood.v114.22.1461.1461.

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Abstract Abstract 1461 Poster Board I-484 The ecotropic viral integration site-1 (Evi-1) locus was originally identified as a common site of retroviral integration in murine myeloid tumors and was later shown to be one of the most potent oncogenenes associated with murine and human myeloid leukemia. More recent data suggest involvement of Evi-1 in embryonic hematopoiesis (Goyama et al, Cell Stem Cell 2008; Yuasa et al, EMBO J, 2005), yet the precise role and molecular regulation of Evi-1 during blood development remains poorly understood. The zebrafish model offers powerful tools for genetic and embryonic studies. Here, we study zebrafish embryonic development and human pluripotent stem cells to understand how evi-1 modulates early hematopoietic development. Loss-of-function studies were performed in vivo by injecting Morpholino oligonucleotides in zebrafish zygotes to inhibit evi-1 pre-mRNA splicing. To control for off-target effects, two separate morpholinos were designed and injected. N=100 zebrafish were analysed pro experiment in each group. Inhibition of evi-1 was confirmed by quantitative PCR comparison in morpholino-injected and control embryos. Hematopoietic development was followed in both morphants and wild-type embryos by simple microscopy and in situ hybridizations using known hematopoeitic markers in order to investigate the developmental time-point in which evi-1 regulates blood development. evi-1 morpholino injected zebrafisch embryo showed severely reduced numbers of circulating blood cells, consistent with the phenotype observed in Evi-1−/− mice. Additionally, hemorrhages were observed, suggesting concomittant defects of the endothelial lineage in evi-1 deficient fish. In situ hybridization analysis on 11-12 somite stage embryos revealed strong reduction of myeloid embryonic hematopoiesis (measured by pu.1 expression in the anterior lateral plate mesoderm), while no change was observed in primitive erythroid progenitor cells (monitored by gata1 expression) or overall in blood and endothelial precursors in the posterior lateral plate mesoderm (as monitored by scl expression). Taken together, our studies demonstrate a strong impact of evi-1 on zebrafish blood development, confirming the results from Evi-1−/− mice. As gata1 expression and therefore erythroid precursor cells in the posterior blood islands are unaffected in evi-1 morphants, our results support the hypothesis that the reduction of primitive yolk-sac erythrocytes in mutant mice was caused from hemorrhages from pericardial effusions. Since erythroid and myeloid cells derive from a common precursor, but gata1 expression was unaffected in knock-down embryos, we anticipate that evi-1 plays a specific role in the myeloid lineage, as shown by abolished pu.1 expression in the anterior LPM. evi-1 therefore probably affects differentiation, survival or proliferation of myeloid cells. Previous reports in adult hematopoietic cells show that evi-1 can interact with both gata1 and pu.1. However, our data suggest that this is not the case during embryonic development, since gata1 expression remained unaltered in morpholino-injected embryos. Furthermore, data in mice suggest that Evi-1 may modulate embryonic hematopoiesis by affecting hematopoietic stem cell proliferation through regulation of Gata2. Currently ongoing experiments in our laboratories focus on characterization of genetic interactions between evi-1, gata2 and pu.1 during zebrafish blood development. Amongst other, gata2 and respectively pu.1 mRNA are co-injected in evi-1 morphants to analyse whether they can rescue the blood phenotype. Moreover, selected findings in zebrafish embryonic development will be verified in the human using using in vitro differentiating human induced pluripotent stem (iPS) cells. First expression data generated by real-time PCR analysis showed differential expression of EVI-1 in embryoid bodies generated from human iPS cells, confirming our hypothesis that EVI-1 has specific effects during human blood development. Disclosures No relevant conflicts of interest to declare.

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You-Jin, Jeon. "Antioxidant Effect of Fucoidan from Miyeokgui, Marine Alga in Zebrafish Model." Journal of Chitin and Chitosan 20, no. 2 (June 30, 2015): 123–30. http://dx.doi.org/10.17642/jcc.20.2.7.

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Jiang, Yanjun, Ye Rong, Ruixue Wu, Yi Wen, and Liu Hu. "A Zebrafish Thrombosis Model for Assessing Antiplatelet Drugs." International Journal of Pharma Medicine and Biological Sciences 9, no. 1 (January 2020): 38–42. http://dx.doi.org/10.18178/ijpmbs.9.1.38-42.

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Singh, Chandra Bhushan, and Badre Alam Ansari. "Bioassay of Profenofos and Cypermethrin on Zebrafish, Daniorerio." Scholars Academic Journal of Biosciences 4, no. 7 (July 2016): 578–82. http://dx.doi.org/10.21276/sajb.2016.4.7.5.

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Oh, Junyoung, Eun-Jin Park, Seongeun Kang, and Seungheon Lee. "Exposure to Dithiopyr Alters Swimming Performance Parameters in Zebrafish." Journal of Life Science 26, no. 2 (February 25, 2016): 181–89. http://dx.doi.org/10.5352/jls.2016.26.2.181.

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Dissertations / Theses on the topic "Zebrafisch"

1

Nold, Elvira. "Die Whn-Genfamilie beim Zebrafisch." [S.l. : s.n.], 2005.

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Fett, Mareike. "Funktionelle Analyse von Parkin im Zebrafisch." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-123597.

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Krawitz, Peter. "Funktionelle Analyse der Signalpeptidpeptidase Familie im Zebrafisch." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-96745.

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Wiest, Waltraud. "Genetischer Screen nach Thymusmutanten im Zebrafisch (Danio rerio)." [S.l. : s.n.], 2001. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9624821.

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Klier, Ina. "Die Untersuchung der menschlichen Kaliumkanalfamilie KCNQ im Modelltier Zebrafisch." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-117370.

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Hans, Stefan. "Eine Charakterisierung cis-regulatorischer Elemente des Zebrafisch deltaD-Gens." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962759805.

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Lourenco, da Conceicao Luz Marta. "Cellular mechanisms involved in Wnt8 distribution and function in zebrafish neurectoderm patterning." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1228815553128-55176.

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Wnt proteins have key roles in patterning of multicellular animals, acting at a distance from their sites of production. However, it is not well understood how these molecules propagate. This question has become even more puzzling by the discovery that Wnts harbour post-translational lipid-modifications, which enhance association with membranes and may therefore limit propagation by simple diffusion in an aqueous environment. The cellular mechanisms involved in Wnt propagation are largely unknown for vertebrate organisms. Here, I discuss my findings on the cellular localization of zebrafish Wnt8, as an example of a vertebrate Wnt. Wnt8 is a key signal for positioning the midbrain-hindbrain brain boundary (MHB) organizer along the anterior-posterior axis of the developing brain in vertebrates. However, it is not clear how this protein propagates from its source, the blastoderm margin, to the target cells, in the prospective neural plate. For this purpose, I have analysed a biologically active, fluorescently tagged Wnt8 in live zebrafish embryos. Wnt8 was present in live tissue in membrane associated punctate structures. In Wnt8 expressing cells these puncta localise to filopodial cellular processes, from which the protein is released to neighbouring cells. This filopodial release requires posttranslational palmitoylation. Although palmitoylation-defective Wnt8 retains auto- and juxtacrine signaling activity, it fails to signal over a long-range. Additionally, this Wnt8 palmitoylation is necessary for regulation of its neural plate target genes. These results suggest that vertebrate Wnt proteins use cell-to-cell contact through filopodia as a shortrange propagation mechanism while released palmitoylated Wnt is required for longrange signaling activity. Furthermore, I show that a Wnt8 receptor, Frizzled9 can negatively influence Wnt8 propagation and signaling range. Finally, I was able to determine the presence of an endogenous Wnt8 gradient in the neurectoderm. I discuss these findings in the context of Wnt8 signaling function in mediating anterior-posterior patterning during early brain development.

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Weber, Michael. "All-Optical 4D In Vivo Monitoring And Manipulation Of Zebrafish Cardiac Conduction." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-166647.

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The cardiac conduction system is vital for the initiation and maintenance of the heartbeat. Over the recent years, the zebrafish (Danio rerio) has emerged as a promising model organism to study this specialized system. The embryonic zebrafish heart’s unique accessibility for light microscopy has put it in the focus of many cardiac researchers. However, imaging cardiac conduction in vivo remained a challenge. Typically, hearts had to be removed from the animal to make them accessible for fluorescent dyes and electrophysiology. Furthermore, no technique provided enough spatial and temporal resolution to study the importance of individual cells in the myocardial network. With the advent of light sheet microscopy, better camera technology, new fluorescent reporters and advanced image analysis tools, all-optical in vivo mapping of cardiac conduction is now within reach. In the course of this thesis, I developed new methods to image and manipulate cardiac conduction in 4D with cellular resolution in the unperturbed zebrafish heart. Using my newly developed methods, I could detect the first calcium sparks and reveal the onset of cardiac automaticity in the early heart tube. Furthermore, I could visualize the 4D cardiac conduction pattern in the embryonic heart and use it to study component-specific calcium transients. In addition, I could test the robustness of embryonic cardiac conduction under aggravated conditions, and found new evidence for the presence of an early ventricular pacemaker system. My results lay the foundation for novel, non-invasive in vivo studies of cardiac function and performance.

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Brand, Michael, Jan Kaslin, Stefan Hans, Julia Ganz, and Oliviera-Carlos Vanessa de. "Notch Receptor Expression in Neurogenic Regions of the Adult Zebrafish Brain." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-189160.

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The adult zebrash brain has a remarkable constitutive neurogenic capacity. The regulation and maintenance of its adult neurogenic niches are poorly understood. In mammals, Notch signaling is involved in stem cell maintenance both in embryonic and adult CNS. To better understand how Notch signaling is involved in stem cell maintenance during adult neurogenesis in zebrafish we analysed Notch receptor expression in five neurogenic zones of the adult zebrafish brain. Combining proliferation and glial markers we identified several subsets of Notch receptor expressing cells. We found that 90 [Formula: see text] of proliferating radial glia express notch1a, notch1b and notch3. In contrast, the proliferating non-glial populations of the dorsal telencephalon and hypothalamus rarely express notch3 and about half express notch1a/1b. In the non-proliferating radial glia notch3 is the predominant receptor throughout the brain. In the ventral telencephalon and in the mitotic area of the optic tectum, where cells have neuroepithelial properties, notch1a/1b/3 are expressed in most proliferating cells. However, in the cerebellar niche, although progenitors also have neuroepithelial properties, only notch1a/1b are expressed in a high number of PCNA [Formula: see text] cells. In this region notch3 expression is mostly in Bergmann glia and at low levels in few PCNA [Formula: see text] cells. Additionally, we found that in the proliferation zone of the ventral telencephalon, Notch receptors display an apical high to basal low gradient of expression. Notch receptors are also expressed in subpopulations of oligodendrocytes, neurons and endothelial cells. We suggest that the partial regional heterogeneity observed for Notch expression in progenitor cells might be related to the cellular diversity present in each of these neurogenic niches.

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Gundlach, Jule [Verfasser]. "Charakterisierung von Olfactomedin im in vivo Modellorganismus Zebrafisch / Jule Gundlach." Ulm : Universität Ulm, 2019. http://d-nb.info/1201603269/34.

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Books on the topic "Zebrafisch"

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service), ScienceDirect (Online, ed. Zebrafish. Amsterdam: Elsevier/Academic Press, 2010.

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Kawakami, Koichi, E. Elizabeth Patton, and Michael Orger, eds. Zebrafish. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3771-4.

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Lieschke, Graham J., Andrew C. Oates, and Koichi Kawakami, eds. Zebrafish. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-977-2.

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McGrath, Patricia, ed. Zebrafish. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118102138.

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Kalueff, Allan V., and Jonathan M. Cachat, eds. Zebrafish Neurobehavioral Protocols. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-60761-953-6.

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Langenau, David M., ed. Cancer and Zebrafish. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30654-4.

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Zebrafish neurobehavioral protocols. New York: Humana Press, 2011.

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Kalueff, Allan V., ed. The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-33774-6.

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Silke, Berger, and Currie Peter, eds. Atlas of zebrafish development. Amsterdam: Academic Press/Elsevier Science, 2012.

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Bryson-Richardson, Robert. Atlas of zebrafish development. Amsterdam: Academic Press/Elsevier Science, 2012.

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Book chapters on the topic "Zebrafisch"

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Lawrence, Christian. "The Reproductive Biology and Spawning of Zebrafish in Laboratory Settings." In Zebrafish, 1–13. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118102138.ch1.

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Li, Chunqi, Wen Lin Seng, Demian Park, and Patricia McGrath. "Methods for Assessing Neurotoxicity in Zebrafish." In Zebrafish, 117–34. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118102138.ch10.

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D'amico, Louis, Chunqi Li, Elizabeth Glaze, Myrtle Davis, and Wen Lin Seng. "Zebrafish: A Predictive Model for Assessing Cancer Drug-Induced Organ Toxicity." In Zebrafish, 135–49. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118102138.ch11.

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MacPhail, Robert C., Deborah L. Hunter, Terra D. Irons, and Stephanie Padilla. "Locomotion and Behavioral Toxicity in Larval Zebrafish: Background, Methods, and Data." In Zebrafish, 151–64. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118102138.ch12.

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Park, Demian, Joshua Meidenbauer, Breanne Sparta, Wen Lin Seng, and Patricia McGrath. "Zebrafish: A Predictive Model for Assessing Seizure Liability." In Zebrafish, 165–75. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118102138.ch13.

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Park, Demian, Maryann Haldi, and Wen Lin Seng. "Zebrafish: A NewIn VivoModel for Identifying P-Glycoprotein Efflux Modulators." In Zebrafish, 177–90. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118102138.ch14.

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Alderton, Wendy. "Assessment of Effects on Visual Function in Larval Zebrafish." In Zebrafish, 191–203. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118102138.ch15.

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Seng, Wen Lin, Yingxin Lin, Susie Tang, and Lisa Zhong. "Development of a Hypoxia-Induced Zebrafish Choroidal Neovascularization Model." In Zebrafish, 205–18. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118102138.ch16.

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Li, Chunqi, Liqing Luo, and Patricia McGrath. "Zebrafish Xenotransplant Cancer Model for Drug Screening." In Zebrafish, 219–32. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118102138.ch17.

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Tang, Jian, Susie Tang, Maryann Haldi, and Wen Lin Seng. "Zebrafish Assays for Identifying Potential Muscular Dystrophy Drug Candidates." In Zebrafish, 233–56. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118102138.ch18.

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Conference papers on the topic "Zebrafisch"

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Mwaffo, Violet, Sachit Butail, and Maurizio Porfiri. "A Three Dimensional Model of Zebrafish Swimming." In ASME 2016 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/dscc2016-9773.

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Zebrafish is becoming an important animal model in pre-clinical studies for its genetic similarity to humans and ease of use in the laboratory. In recent years, animal experimentation has faced several ethical issues, calling for alternative methods that capitalize on dynamical systems theory. Here, we propose a computational modeling framework to simulate zebrafish swimming in three dimensions (3D) in the form of a coupled system of stochastic differential equations. The model is capable of reproducing the burst-and-coast swimming style of zebrafish, speed modulation, and avoidance of tank boundaries. Model parameters are calibrated on an experimental dataset of zebrafish swimming in 3D and validated by comparing established behavioral measures obtained from both synthetic and experimental data. We show that the model is capable of accurately predicting fish locomotion in terms of the swimming speed and number of entries in different sections of the tank. The proposed model lays the foundations for in-silico experiments of zebrafish neurobehavioral research.

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Alkawari, Fatima, Wigdan Ali, Fatiha Benslimane, and Huseyin Yalcin. "Investigating the Cardiac effects of New Generation Anti-Diabetic Drug Empagliflozin using Zebrafish Embryo Model." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0211.

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Type 2 diabetes mellitus (T2DM) affects >16% of adults in Qatar. Newly emerging class of antidiabetic drugs focused on SGLT inhibition were observed to reduce CVDs risks in diabetic patients. Up to date, the mechanism contributing to the CV benefits remains unrevealed. Zebrafish embryos were treated with Aristolochic Acid to induce heart failure then treated with Empagliflozin to determine its beneficial effect. Furthermore the expression of SGLT1 & 2 were determined in the hearts of zebrafish. SGLT2 was expressed more then SGLT1 in the heart and whole embryo. Empa significantly improved the zebrafish embryo'scardiachealthafterinductionofheartfailure.

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Butail, Sachit, Tiziana Bartolini, and Maurizio Porfiri. "Collective Response of Zebrafish to a Mobile Robotic Fish." In ASME 2013 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/dscc2013-3748.

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We investigate the response of groups of zebrafish, a model social organism, to a free-swimming robotic fish. The robot has a body and tail section and moves forward by beating the tail. Steering control is achieved by offsetting the beating tail with respect to the body. The color pattern and shape of the robot are informed by visual cues known to be preferred by zebrafish. A real-time multi-target tracking algorithm uses position and velocity estimates to autonomously maneuver the robot in circular trajectories. Observables of collective behavior are computed from the fish trajectory data to measure cohesiveness, polarization, and speed of the zebrafish group in two different experimental conditions. We show that while fish are significantly less polarized in the presence of the robot with an accompanying change in average speed, there is no significant change in the degree of cohesion.

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Scherr, Thomas F., Gerald Knapp, Terrence Tiersch, W. Todd Monroe, and Krishnaswamy Nandakumar. "The Activation of Zebrafish Sperm Cells in a Micromixer." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14734.

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The freshwater fish, Danio rerio (zebrafish), have become widely used as a model organism for vertebrate development, DNA mutation, and human disease studies [1]. Maintaining live colonies of the numerous developed strains of zebrafish under investigation can be prohibitively costly. As such, there is a growing need to catalog their reproductive cells and have them available on demand [2]. Thus cryopreservation of model strain gametes has become an important endeavor, where evaluation of freezing and thawing techniques is currently a bottleneck to these procedures.

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Bommer, Kathleen M., Angela DiBenedetto, and Jens O. M. Karlsson. "High-Speed Imaging of Intra-Embryonic Phase Transformation Events During Rapid Freezing of Zebrafish Embryos." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53953.

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The zebrafish (Danio rerio) represents an increasingly popular vertebrate animal model valuable for genetic and developmental biology research, due to its rapid rate of reproduction and the ability to directly observe the growing embryos, which are optically clear and develop ex vivo. However, the need to maintain live stock of each genetic strain (the number of which is growing exponentially) is risky and prohibitively costly. Although long-term banking of frozen embryos would solve this problem, to date, no adequate method for cryopreservation of zebrafish embryos has been found (Hagedorn et al., 2004).

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Chen, Chia-Yuan, Michael J. Patrick, Paola Corti, David Frakes, Beth L. Roman, and Kerem Pekkan. "In Vivo Hemodynamic Performance of Wild-Type vs. Mutant Zebrafish Embryos Using High-Speed Confocal Micro-PIV." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19317.

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In developing cardiovascular systems, definite performance comparison between disease and healthy hemodynamics requires quantitative tools to support advanced microscopy. Mutations in the activin receptor-like kinase 1 (ALK1) gene are responsible for the autosomal dominant vascular disease, hereditary hemorrhagic telangiectasia type 2 (HHT2), characterized by high flow arteriovenous malformations (AVMs) [1]. Recent studies show that the zebrafish mutant violet beauregrade (vbg), which harbors a mutation in alk1, develops an abnormal circulation with dilated cranial vessels and AVMs [2]. Quantitative understanding of mechanical influences on the alk1 mutant phenotype will aid treatment of HHT2 patients. Inspired by earlier studies that demonstrate the capability of using confocal micro-PIV technique to quantify biofluid dynamics in vivo [3], primarily in major vessels (dorsal aorta, vitelline veins), the present study focused on secondary branching great vessels of zebrafish embryos where microcirculation flow regimes are different. Furthermore, confocal microscopy, essentially being an imaging modality, requires rigorous validation efforts with respect to the gold standard measurement protocols (such as PIV) and synthetic scan data. Another objective of this work was to document the intra-species differences of wall shear stress (WSS) and flow physics during embryonic development in aortic arch systems of zebrafish [4].

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Essa, Asma, Noura Aldous, Fatiha Benslimane, and Huseyin Yalcin. "In Vivo Investigation of Cardiac benefits of Sodium Glucose Cotransporter Inhibition using the Zebrafish Model." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0199.

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Type 2 diabetes mellitus (T2DM) affects >16% of adults in Qatar. Newly emerging class of antidiabetic drugs, focused on SGLT inhibition were observed to reduce CVDs risks in diabetic patients. Up to date, the mechanism contributing to the CV benefits remains unrevealed. Zebrafish embryos were injected with different morpholinos to knockdown SGLT genes and study their effects on cardiac parameters. SGLT1 inhibition caused the most severe effects on zebrafish embryos with survival rate ~10 %. It also caused tube-like structured heats with edema, affecting significantly the cardiac output and diameter, and increased cardiac markers expressions. Analysis acquired correlates with literature data of SGLT1 predominant expression in heart tissues.

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Tiamning Liu, Jingxin Nie, Gang Li, Lei Guo, and Stephen TC Wong. "ZFIQ: Zebrafish Image Quantitator." In 2007 IEEE/NIH Life Science Systems and Applications Workshop. IEEE, 2007. http://dx.doi.org/10.1109/lssa.2007.4400884.

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Al-Jighefee, Hadeel, Roba Abdin, Gheyath Khalid Nasrallah, and Ola Aljamal. "Toxicity Evaluation of Stearamidopropyl Dimethylamine Surfactant on Embryonic development of Zebrafish." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0194.

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Background: Surfactants best known for their use in the industry of detergents, household products, and cosmetics. Usually, the amount of released surfactants into the environment is diluted during secondary water treatment. However, there is always a risk of releasing untreated and polluted wastewater containing high amounts of surfactants without knowing the harmful effect on biotic and abiotic elements of the environment. SAPDMA is a surfactant that is used mostly in cosmetics, conditioning agents, and recently in corrosion inhibition. The classification of SAPDMA as a “safe” or “green” surfactant by different environment or chemical agencies is ambiguous, and the literature is lacking. Aim: The aim of this study is to evaluate the safety of SAPDMAusing the zebrafish embryo model. Methods: Zebrafish embryos were exposed to different concentrations of SAPDMA and the effect was assessed by different toxicity assays. This includes mortality/ survival assay to assess the median lethal dose (LC50) teratogenicity assay to assess the no observed effect concentration (NOEC); and organ specific toxicity assays including cardiotoxicity, neurotoxicity (using locomotion assay), and hemoglobin synthesis (using odianisidine staining). Results: Exposure of zebrafish embryos to SAPDMA caused mortality in a dose-dependent manner with a calculated LC50 of 2.3 mg/L. Thus, based on the LC50 value and according to the Fish and Wildlife Service Acute Toxicity Rating Scale, SAPDMA is classified as “moderately toxic”. The NOEC, the concentration that did not cause any significant teratogenicity, was 0.1mg/L. However, this concentration caused significant organ specific and cytotoxic effects, suggesting that harmless concentrations of SAPDMAare lower than 0.1 mg/L. Conclusion: Our data indicate that SAPDMA at very low concentrations causes adverse effects on zebrafish embryos. Thus, we recommend that the use of SAPDMA in industry should be re-evaluated and monitored by the environment and public health agencies.

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Nasser, Fatima Abdulwahab, Halah Noor Nasir, Zain Zaki Zakaria, and Huseyin Yalcin. "Toxicity Assessment of Treated Sewage Effluent using the Zebrafish Embryo Model." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0218.

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Background: In a context of tremendous economic value, the management and protection of water resources in Qatar has long been a significant issue as part of the global wastewater management plan. The process is based on several stages of treatment in order to deliver high-quality effluent standard. Treated sewage effluent (TSE) can potentially be used for agriculture in Qatar and it should be biologically evaluated before releasing it to the environment. TSE water can be further filtered with techniques that include reverse osmosis, forward osmosis, and nanofiltration. Aim: This project aims to assess the toxicity of differently treated sewage effluent water on the environement using the zebrafish model. Our approach will also be relevant to the assessment of the water quality for agriculture use. Methods: Zebrafish embryos were cultured in different effluent water samples filtered with different techniques. Toxicicity of water was assessed via multiple assasys including: survival rate, tail flicking, and hatching rate. Cardiotoxicity assessment was performed via blood velocity, cardiac output and vessels diameter measurement in major vessels, as well as gene expression for heart failure markers of ANP and BNP by PCR. Results: Samples filtered via Reverse osmosis and nano-filtration resulted in most toxicity. Total dissolved solvent (TDS) measurements were also highest in those samples, suggesting these filteration techniques may result in release of toxic compounds to effluent water. Toxicity assessment is currently ongoing to confirm the findindgs. Conclusion: Utilization of TSE for environmental and agricultural purposes will have an economical value in the nation. It is critically important to determine the most efficient and less toxic ways of water filteration. Zebrafish is a practical model that can be used to assess water toxicity. This project aims to examine toxicity of effluent water filteration techniques using the zebrafish model.

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Reports on the topic "Zebrafisch"

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Ess, Kevin. Neural Development in tsc2-Deficient Zebrafish. Fort Belvoir, VA: Defense Technical Information Center, October 2011. http://dx.doi.org/10.21236/ada590191.

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Gutierrez, Alejandro. Zebrafish Functional Genetics Approach to the Pathogenesis of Well-Differentiated Liposarcoma. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada619141.

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Czezyk, Aleksandra, Charlotte Burn, and Claire Russell. Does Providing Hiding Spaces for Zebrafish in Large Groups Reduce Aggressive Behaviour? Journal of Young Investigators, November 2020. http://dx.doi.org/10.22186/jyi.38.5.43-56.

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Beirl, Alisha. Investigating a Role for the CCAAT/Enhancer-Binding Protein δ in the Developing Zebrafish. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.1650.

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Epstein, Jonathan A. Developing a Zebrafish Model of NF1 for Structure-Function Analysis and Identification of Modifier Genes. Fort Belvoir, VA: Defense Technical Information Center, April 2008. http://dx.doi.org/10.21236/ada485806.

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Epstein, Jonathan A. Developing a Zebrafish Model of NF1 for Structure-Function Analysis and Identification of Modifier Genes. Fort Belvoir, VA: Defense Technical Information Center, April 2009. http://dx.doi.org/10.21236/ada502775.

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Look, A. T. Zebrafish Model of NF1 for Structure-Function Analysis, Mechanisms of Glial Tumorigenesis, and Chemical Biology. Fort Belvoir, VA: Defense Technical Information Center, May 2014. http://dx.doi.org/10.21236/ada609199.

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Epstein, Jonathan A., and A. T. Look. Developing a Zebrafish Model of NF1 for Structure-Function Analysis and Identification of Modifier Genes. Fort Belvoir, VA: Defense Technical Information Center, April 2012. http://dx.doi.org/10.21236/ada570844.

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Look, A. T. Zebrafish Model of NF1 for Structure-Function Analysis, Mechanisms of Glial Tumorigenesis, and Chemical Biology. Fort Belvoir, VA: Defense Technical Information Center, May 2013. http://dx.doi.org/10.21236/ada581661.

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Kokkotou, Efi. Investigation of the Role of Stress in Inflammatory Bowel Disease Using Zebrafish as an Experimental Model. Fort Belvoir, VA: Defense Technical Information Center, August 2012. http://dx.doi.org/10.21236/ada566781.

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