Academic literature on the topic 'Zelené stezky'

An Overview of the Role of Traditional Institutions in Nigeria Mustapha Alhaji Ali Department of Political Science and Administration. Yobe State University, Damaturu. Nigeria Fatima Ahmed Department of Political Science University of Maiduguri Nigeria *Corrosponding author’s Email: mustaphaalhajiali2@gmail.com Mustapha Alhaji Ali, born in Yobe state Nigeria, a staff of Yobe State University. Currently pursuing Ph.D. Political Science in Universiti Utara Malaysia is the based eminent Management University. The University in the green forest. Fatima Ahmed was born in Borno state Nigeria, working with the University of Maiduguri. Presently pursuing Ph.D. Political Development in the University the famous university in the North-Eastern region. Peer-review under responsibility of 3rd Asia International Multidisciplanry Conference 2019 editorial board (http://www.utm.my/asia/our-team/) © 2019 Published by Readers Insight Publisher, lat 306 Savoy Residencia, Block 3 F11/1,44000 Islamabad. Pakistan, info@readersinsight.net This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Research Highlights The British officials in Nigeria framed and imposed rules and laws through the traditional rulers who only served as mediators between the people and the British officials. Though, the cultures and traditions of the Nigerian citizens were cherished and reserved by the British government in order to accept and welcome them by the citizens of the country. However, this system worked out well because of the support of the traditional rulers who claimed that since their cultures and traditions were not interfered with, they have no problem with the British authorities (Teslim, 2019). Before traditional rulers in everywhere in the world are attached with some important functions among which are contributing to development administration, linkage or "brokering" between grassroots and capital, extension of national identity through the conferral of traditional titles, low-level conflict resolution and judicial gate-keeping, ombudsmanship and institutional safety- valve for overloaded and sub-apportioned bureaucracies. In addition to the above roles, traditional rulers are meant to create educated chieftaincies meaningfully improves the success of traditional rulers (Miles, 1993). Furthermore, traditional rulers serve as another institute of conflict resolution in any nation where the state legal system is weakening to fully provide the judicial requirements of the country (Zeleke, 2011). A study by Isaac (2018) disclosed that in the olden days, traditional institutions are the administrative organizations in Nigeria. These establishments are entrenched in the history, cultures, and the traditions of several ethnic groups and cultural background. He further explained that traditional institutions plays an important role in the managerial process before, during, and after colonial rules, these institutions have contributed to the history of the nation. The role of traditional organizations was important and highly respected during these periods. Research Objectives The paper examined the roles of traditional institutions toward steady democracy To discover how efficient are these institutions in ensuring steady democracy Significance of the study This study is of great importance to the academician because it would add to the body of existing knowledge, by guiding and assisting students conducting research in a similar field of study. However, this research work is very significant because it would help the traditional institution in understanding their weakness and how to improve where necessary.This study helps in identifying the gap in the literature and it as well assists in filing the existing gap in the literature Methodology This paper is qualitative in nature because it is based on an organized review of related literature and a subtle examination of secondary data, in this case, data were established from various sources such as magazines, published and unpublished articles, books, journals, reports archives and newspaper articles (Braun & Clarke, 2013; Creswell, 2009). Research Design Under the research design the researcher adopted case study approach this is because it provides the researcher with an in-depth understanding of a phenomenon under inquiry, or it helps in providing an in-depth thoughtful of cases (Creswell, 2013; Othman, 2018). Theoretical Framework There are many theories that can explain these study, but for the purpose of this paper the researcher used two theories, these are dependency and servant leadership theory, and reason for using these theories is based on their applicability and relationship with the topic under examination, these theories dwelled on abilities of leader and leadership independence in all the society. The postulations of these theories are that traditional rulers should be an independent body, truthful, honest, loyal, responsible, forecast, sensible and above all dedication to administrative responsibilities (White and Clark, 1990; Stone, & Patterson, 2005). Findings Traditional rulers play an important role in the society by advising the elected leaders in different areas, these include; economic policy, security issues, equal sharing of goods and services, recommending aspirants for elections or appointment to serve the community, demand for good governance and general wellbeing of the people among others. Study by Lund (2006) and Osifo (2017) disclosed that before traditional institutions use religion power to settle disputes among the citizens as well as married couples in the society, it also uses religious sanctions in resolving issues related to land disputes among the people in their respective societies, and issues like robbery, and disputes between neighbors in the societies. Recommendations The paper recommended that traditional rulers should be given full independence and should be well connected into Nigeria democratic process, this would encourage them to contribute in no small measure to the social and economic development. The study further recommended that democratization of the states along traditional organization would help in enhancing economic development that would enhance the living standard of the citizens Conclusion The study concluded that traditional institutions play important roles in the olden day. By settling disputes among the citizens. They in addition help in maintaining peace and order among the general populace. References a Stone, A. G., & Patterson, K. (2005). The history of leadership focus.Servant leadership research roundtable proceedings.School of Leadership Studies, Regent University, Virginia Beach, US. Teslim, O. O. (2019). Indirect Rule in Nigeria. Victor O. (2017). 7 Roles of Traditional Rulers in Achieving Stable Democracy in Nigeria. Information Guide in Nigeria. White, L.G. & Clark, R. P. (1990). Political Analysis: Technique and Practice. California: Brooks/Cole Publishing Company. Yemisi O. I. (2018). Role of Traditional Institution in Nigeria Democratic Space: Contending Perspectives, Issues, and Potentials. Zaleha O. (2018). Important things about Qualitative Research. Zeleke, M. (2011). Ye Shakoch Chilot (the court of the sheikhs): A traditional institution of conflict resolution in Oromiya zone of Amhara regional state, Ethiopia. African Journal on Conflict Resolution, 10(1), 63–84.

The subject of the Diploma thesis is an urban study in the area of the former part of Tepna in Náchod. The Tepna area is largely after demolition and is currently dilapidating. This area has the potential for development and use, located within a short walking distance from the historic city center and at the same time from the residential area in the northern part of Náchod. Above the solved area is the castle, which is a dominant and a city landmark. The aim of the proposal was to use the potential of the territory at most, but at the same time to approach the surrounding landscape sensitively and to connect the urban character of the surrounding urban structure of the city and, conversely, the existing buildings of unclosed blocks are supplemented by new development.

The main goal of my work was to determine knowledge of the Třeboň Region as a unique nature area not only for the Czech Republic but also for all of Europe, knowledge and use of educational trails, the spa function of the town and knowledge of the Třeboň Region in general.

Toleranz gegenüber Selbstantigenen in den peripheren Geweben kann durch CD4+ CD25+ Foxp3+ regulatorische T-Zellen (Tregs) vermittelt werden. Diese Zellen entstehen entweder in Folge der thymischen T-Zellselektion (natürlich vorkommende Tregs, nTreg) oder durch Konversion aus naiven T-Zellen in den peripheren lymphatischen Organen (induzierte Tregs, iTregs). Im Vorfeld der Arbeit war bereits bekannt, dass Dendritische Zellen (DZ) eine wichtige Rolle bei der Generierung von iTreg spielen. Allerdings bestand weitestgehend Unklarheit darüber, welche DZ in welchem Reifungszustand dazu in der Lage sind, iTregs gegen peripher-exprimierte Selbstantigene zu induzieren. Steady-state migratorische DZ (ssmDZ) gelten in dieser Hinsicht als potentielle Kandidaten, da bekannt ist, dass diese DZ bereits unter homöostatischen Bedingungen Selbstantigene aus peripheren Geweben in die drainierenden Lymphknoten transportieren und dort T-Zellen präsentieren können. Ein Ziel der vorliegenden Arbeit war daher, den Phänotyp und die tolerogene Kapazität der ssmDZ in den hautdrainierenden Lymphknoten näher zu untersuchen. Es konnte gezeigt werden, dass ssmDZ einen semireifen MHC IIint CD40hi CD80/CD86int CCR7+ Phänotyp aufweisen und in vitro mit Hilfe von endogenem TGF-β iTregs induzieren können. Darüber hinaus belegt diese Arbeit zusammen mit weiteren Daten aus unserer Arbeitsgruppe, dass ssmDZ in transgenen K5mOVA-Mäusen zellassoziertes epidermales OVA aus der Haut in die drainierenden Lymphknoten transportieren und dort an CD4+ OVA-spezifische TZR-transgene OT-II T-Zellen präsentieren können. Innerhalb der ssmDZ konnten die Langerin+ dermalen DZ als die DZ-Subpopulation eingegrenzt werden, die für die Konversion von naiven OT-II T-Zellen in CD4+ CD25+ Foxp3+ iTregs verantwortlich war. Ferner zeigte sich, dass CD103 nicht als Marker für ssmDZ in den hautdrainierenden Lymphknoten herangezogen werden kann. Ein weiteres Ziel dieser Arbeit war, herauszufinden, welchen Einfluss der Transkriptionsfaktor RelB auf die partielle Reifung und Migration der ssmDZ hat. RelB ist ein Mitglied der NF-κB-Familie und wird mit der Reifung von DZ in Verbindung gebracht. Erste Experimente zeigten eine nukleäre Translokation von RelB in ssmDZ sowie eine verringerte Frequenz dieser DZ in den hautdrainierenden Lymphknoten von relB+/- Mäusen und Mäusen mit einer Defizienz für den RelB-Bindungspartner p52. Allerdings konnte bei Mäusen mit einer DZ-spezifischen RelB-Inaktivierung (RelBDCko Mäuse) eine erhöhte Frequenz an ssmDZ in den hautdrainierenden Lymphknoten festgestellt, die nicht auf einer Zunahme an DZ in der Haut der Tiere zurückzuführen war. Diese Ergebnisse legen einerseits die Vermutung nahe, dass es sich bei den beobachteten Effekte in den relB+/- Mäusen um DZ-extrinsische Auswirkungen auf die ssmDZ handelt. Andererseits scheint RelB unter homöostatischen Bedingungen die Erhaltung und Migration der ssmDZ eher negativ zu beeinflussen. Weitere durchflusszytometrische Analysen wiesen zudem darauf hin, dass RelB in ssmDZ die Expression von Reifungsmarkern nur partiell reguliert. So konnte auf den ssmDZ in den hautdrainierenden Lymphknoten von RelBDCko Mäusen eine erhöhte Expression von CD40 beobachtet werden, während andere Reifungsmarker wie MHC II, CD80 und CD86 nicht signifikant in ihrer Expression betroffen waren. Im Rahmen dieser Arbeit wurde zudem untersucht, wie sich eine RelB-Defizienz in DZ auf die Homöostase und Induktion von Tregs auswirkt. Die hierzu analysierten RelBDCko Mäuse wiesen eine erhöhte Frequenz und absolute Zellzahl an Tregs in allen untersuchten lymphatischen Organen (hautdrainierende Lymphknoten, Milz und Thymus) auf. Darüber hinaus war in diesen Organen auch eine verstärkte Proliferation der Tregs gegenüber den Kontrolltieren festzustellen. Weitere Untersuchungen zeigten, dass die Proliferation der Tregs in RelBDCko Mäusen in den hautdrainierenden Lymphknoten sogar stärker ausfiel als in der Milz. RelB scheint somit die tolerogene Kapazität der DZ zur Regulation der Treg-Expansion im Thymus und in der Peripherie zu beeinflussen. Unter Verwendung von neutralisierenden αIL-2-Antikörpern konnte zudem belegt werden, dass die periphere Proliferation der Tregs in den RelBDCko Mäusen von IL-2 abhängig ist. Damit einhergehend zeigten erste Vorversuche eine erhöhte IL-2-Produktion in den peripheren lymphatischen Organen von RelBDCko Mäusen. Zusammenfassend legen die Daten dieser Arbeit den Schluss nahe, dass ssmDZ in den hautdrainierenden Lymphknoten in der Lage sind, Toleranz durch Induktion von iTregs gegen epidermale Selbstantigene zu induzieren. Untersuchungen an neuartigen Mäusen mit einer konditionalen RelB-Inaktivierung spezifisch in DZ deuten darauf hin, dass die Migration und Reifung von ssmDZ partiell durch RelB reguliert wird. Da Tregs eine Schlüsselrolle bei der Erhaltung der peripheren Toleranz einnehmen, ist die Beobachtung, dass eine RelB-Defizienz in allen DZ zu einer verstärkten Treg-Proliferation und somit zu einer veränderten Treg-Homöostase führt, ein intererssanter Ausgangspunkt für weitere Untersuchungen
Tolerance against self-antigens from peripheral tissues can be mediated through CD4+ CD25+ Foxp3+ regulatory T cells (Tregs). These cells develop either during thymic T cell selection (nTregs) or by conversion from naive CD4+ CD25- Foxp3- T cells in peripheral lymphoid organs (induced Tregs, iTregs). During the last years, a role for dendritic cells (DC) in the generation of iTregs has been clearly established. However, the precise DC subset and maturation stage which are required to induce iTregs against peripheral self-antigens remain unknown. Steady-state migratory DC (ssmDC) are a good candidate to carry out such function, since these cells are able to transport self-antigen from peripheral tissues to draining lymph nodes under steady-state conditions. Thus one aim of this thesis was to define the phenotype and tolerogenic capacity of ssmDC in skin-draining lymph nodes. Here, we show that ssmDC display a partially mature MHC IIint CD40hi CD80/CD86int CCR7+ phenotype and that these DC used endogenous TGF-β to convert naive T cells into iTregs in vitro. This study, together with former data generated in our laboratory, demonstrate that in transgenic K5mOVA mice, ssmDC transport and present cell-associated epidermal OVA to CD4+ OVA-specific TCR-transgenic OT-II T cells in the skin-draining lymph nodes. We also identified langerin+ dermal DC cells among the different subsets of ssmDC, as the subset which mediates the conversion of naïve OT-II T cells into CD4+ CD25+ Foxp3+ iTregs. Furthermore, we observed that CD103 was not a suitable marker for ssmDC in skin-draining lymph nodes despite that it has been correlated with tolerogenic DC in the intestine. An additional aim of this work was to investigate the impact of the transcription factor RelB on the partial maturation and migration of ssmDC. RelB is a member of the NF-κB family and has been associated with DC maturation. Initial experiments showed nuclear translocation of RelB in ssmDC and in addition, relB+/- mice as well as mice with a deficiency of the RelB-binding partner p52 had a reduced migration of ssmDC to skin-draining lymph nodes. Nevertheless, the analysis of mice with a DC-specific ablation of RelB (RelBDCko mice) revealed an increased frequency of ssmDC in skin-draining lymph nodes which was not due to an increased number or altered distribution of DC in the skin. On the one hand, these data suggest that the effects on ssmDC seen in the relB+/- mice were mediated by DC-extrinsic mechanisms. On the other hand, the increase of ssmDC in RelBDCko mice indicated that RelB might be rather a negative regulator of ssmDC migration under homeostatic conditions. Moreover, RelB also affected the maturation of ssmDC partially, since ssmDC in the skin-draining lymph nodes of RelBDCko mice expressed more CD40 on their surface, while other maturation markers as MHC II, CD80 and CD86 were not significantly altered. Finally, it was investigated how RelB deficiency in DC affects the induction and homeostasis of Tregs. To this aim we examined RelBDCko mice in which we observed an increased frequency and absolute number of Tregs in all lymphatic organs analyzed (skin-draining lymph nodes, spleen and thymus). Furthermore, Tregs showed an increased proliferation in these organs compared to control mice. In particular, Tregs in RelBDCko mice proliferated more vigorously in the skin-draining lymph nodes compared to the spleen. Thus, RelB seems to influence the tolerogenic DC capacity by regulating the expansion of Tregs generated in the thymus as well as their peripheral maintenance. By using a neutralizing anti-IL-2 antibody, we could also demonstrate that the peripheral proliferation of Tregs in the RelBDCko mice was dependent on IL-2, indicating that production of IL-2 either by conventional T cells or DC themselves is affected through RelB deficiency. In accordance with this observation, preliminary experiments showed an increased IL-2 production in the peripheral lymphoid organs of RelBDCko mice. Taken together, the data of this study strongly suggest that ssmDZ are potent inducers of iTregs in response to epidermal self-antigens in skin-draining lymph nodes. Moreover, the analysis of a novel conditional mouse model with a DC-specific deletion of RelB indicated that the migration and maturation of ssmDC is partially regulated by RelB. Since Tregs play a key role in the maintenance of peripheral tolerance, our finding that a deficiency of RelB in all DC affects the proliferation and therefore the homeostasis of Tregs provides an interesting starting-point for further investigation