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Journal articles on the topic 'Zero Maze'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Nisbett, Khalin E., Leandro F. Vendruscolo, and George F. Koob. "Indulging Curiosity: Preliminary Evidence of an Anxiolytic-like Effect of Castor Oil and Ricinoleic Acid." Nutrients 16, no. 10 (2024): 1527. http://dx.doi.org/10.3390/nu16101527.

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In the process of validating the elevated zero maze, a common test of anxiety-like behavior, in our laboratory, we demonstrated an anxiolytic-like effect of castor oil and its primary component, ricinoleic acid. We tested the effects of vehicle and chlordiazepoxide in male mice in the elevated zero maze following a 30-min pretreatment time. Chlordiazepoxide is a United States Food and Drug Administration-approved drug that was previously shown to exert anxiolytic-like effects in both the elevated zero maze and elevated plus maze. Chlordiazepoxide was administered at doses of 5 or 10 mg/kg. We

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2

Singh, K., M. Bishnoi, and S. K. Kulkarni. "Elevated Zero-maze: A paradigm to evaluate anti-anxiety effects of drugs." Methods and Findings in Experimental and Clinical Pharmacology 29, no. 5 (2007): 343. http://dx.doi.org/10.1358/mf.2007.29.5.1117557.

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3

Hubbard, Amanda J., Gordon C. Carstens, Lydia Forehand, and Courtney L. Daigle. "The Bovine Zero Maze: Development of a novel fear test for cattle." Applied Animal Behaviour Science 221 (December 2019): 104865. http://dx.doi.org/10.1016/j.applanim.2019.104865.

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4

Rodriguez, Mya N., and Stephen L. P. Lippi. "Lion’s Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model." Behavioral Sciences 12, no. 7 (2022): 235. http://dx.doi.org/10.3390/bs12070235.

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Alzheimer’s disease (AD) significantly impairs the life of an individual both cognitively and behaviorally. Tau and beta-amyloid (Aβ) proteins are major contributors to the etiology of AD. This study used mice modeling AD through the presence of tau pathology to assess the effects of Hericium erinaceus (H. erinaceus), also known as Lion’s mane, on cognitive and non-cognitive behaviors. Despite neurocognitive and neurobiological effects of H. erinaceus being seen in both healthy and transgenic mice, no research to date has explored its effects on mice with solely tau pathology. In this study, m

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Adegbesan, Kendra, Francesco Tomassoni Ardori, Sudhirkumar Yanpallewar, et al. "DISP-13. FEMALE MICE HAVE GREATER SUSTAINED ACTIVITY SUPPRESSION AND HYPERSOMNOLENCE AFTER RADIATION THERAPY: EXPLORATION OF SEX DIFFERENCES IN A MODEL OF CRANIAL-RADIATION-INDUCED HYPERSOMNOLENCE (C-RIH)." Neuro-Oncology 24, Supplement_7 (2022): vii130. http://dx.doi.org/10.1093/neuonc/noac209.495.

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Abstract Female cancer patients have a better prognosis but more adverse events with chemotherapy; less is known with other cancer treatments like radiation therapy. Previous literature has demonstrated sex-dependent effects on the hippocampi and behavioral tasks within post-natal mice after radiotherapy. We explored the differences in activity and sleep in adult male and female mice within our previously established mouse model of cranial-irradiation-induced hypersomnolence (C-RIH). Ten mice of each sex (B6 x B6D2 backcrossed with C57/b6NCr) were observed for general activity and sleep contin

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Uwano, Fumito, and Keiki Takadama. "Comparison Between Reinforcement Learning Methods with Different Goal Selections in Multi-Agent Cooperation." Journal of Advanced Computational Intelligence and Intelligent Informatics 21, no. 5 (2017): 917–29. http://dx.doi.org/10.20965/jaciii.2017.p0917.

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This study discusses important factors for zero communication, multi-agent cooperation by comparing different modified reinforcement learning methods. The two learning methods used for comparison were assigned different goal selections for multi-agent cooperation tasks. The first method is called Profit Minimizing Reinforcement Learning (PMRL); it forces agents to learn how to reach the farthest goal, and then the agent closest to the goal is directed to the goal. The second method is called Yielding Action Reinforcement Learning (YARL); it forces agents to learn through a Q-learning process,

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Amit, Gupta* Kamal Kishore Maheshwari. "EVALUATION OF THE ANXIOLYTIC ACTIVITY OF CURCUMIN AGAINST LEAD INDUCED ANXIETY IN RATS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 441–47. https://doi.org/10.5281/zenodo.1036464.

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Present research work was performed to evaluate the anxiolytic activity of curcumin against lead induced anxiety in rat. Anti-anxiety potentials of the curcumin were compared with diazepam. Lead poisoning induced severe behavioral abnormalities in experimental animals. Rats of either sex were divided into 12 groups of 6 animals in each group. Group were DMSO, Distilled Water, Saline water, Lead acetate 25mg/kg, Diazepam 2mg/kg, Curcumin 25mg/kg, Curcumin 50mg/kg, Diazepam 2mg/kg + lead acetate, Curcumin 25mg + lead acetate, Curcumin 50mg + lead acetate, Diazepam 2mg/kg + Curcumin 50mg and Diaz

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8

Heredia, Luis, Margarita Torrente, María T. Colomina, and José L. Domingo. "Assessing anxiety in C57BL/6J mice: A pharmacological characterization of the zero maze test." Journal of Pharmacological and Toxicological Methods 68, no. 2 (2013): 275–83. http://dx.doi.org/10.1016/j.vascn.2013.02.010.

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9

Sommovilla, Joshua, Warren B. Bilker, Ted Abel, and Richard M. Schultz. "Embryo culture does not affect the longevity of offspring in mice." Reproduction 130, no. 5 (2005): 599–601. http://dx.doi.org/10.1530/rep.1.00872.

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The oldest assisted reproductive technologies (ART)-conceived child is only 27 years old. Thus, the effects of ART on longevity are unknown, and it will be many years before this can be assessed in humans. We recently reported that culturing preimplantation mouse embryos under suboptimal conditions results in differences in how the offspring perform in behavioral assays that reflect anxiety (elevated zero maze) and spatial memory (Morris hidden water maze; Ecker et al. 2004). Here we monitored the mice generated in our previous study and found no difference in their longevity.

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10

Kõiv, Kadri, Denis Matrov, Trine Uusen, and Jaanus Harro. "Effect of Neuropeptide S Administration on Ultrasonic Vocalizations and Behaviour in Rats with Low vs. High Exploratory Activity." Pharmaceuticals 14, no. 6 (2021): 524. http://dx.doi.org/10.3390/ph14060524.

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Neuropeptide S (NPS) is a peptide neurotransmitter that in animal studies promotes wakefulness and arousal with simultaneous anxiety reduction, in some inconsistency with results in humans. We examined the effect of NPS on rat ultrasonic vocalizations (USV) as an index of affective state and on behaviour in novel environments in rats with persistent inter-individual differences in exploratory activity. Adult male Wistar rats were categorised as of high (HE) or low (LE) exploratory activity and NPS was administered intracerebroventricularly (i.c.v.) at a dose of 1.0 nmol/5 µL, after which USVs

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11

Troelsen, K. B., E. ?? Nielsen, and N. R. Mirza. "A72 THE EFFECT OF ACUTE AND CHRONIC MONOAMINE REUPTAKE INHIBITORS IN THE MOUSE ZERO-MAZE." Behavioural Pharmacology 16, Supplement 1 (2005): S45—S46. http://dx.doi.org/10.1097/00008877-200509001-00144.

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12

Shepherd, Jon K., Savraj S. Grewal, Allan Fletcher, David J. Bill, and Colin T. Dourish. "Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety." Psychopharmacology 116, no. 1 (1994): 56–64. http://dx.doi.org/10.1007/bf02244871.

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13

Elkhatib, Safwan K., Cassandra M. Moshfegh, Gabrielle F. Watson, and Adam J. Case. "Peripheral inflammation is strongly linked to elevated zero maze behavior in repeated social defeat stress." Brain, Behavior, and Immunity 90 (November 2020): 279–85. http://dx.doi.org/10.1016/j.bbi.2020.08.031.

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14

Crowe, David A., Bruno B. Averbeck, Matthew V. Chafee, John H. Anderson, and Apostolos P. Georgopoulos. "Mental Maze Solving." Journal of Cognitive Neuroscience 12, no. 5 (2000): 813–27. http://dx.doi.org/10.1162/089892900562426.

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We sought to determine how a visual maze is mentally solved. Human subjects (N = 13) viewed mazes with orthogonal, unbranched paths; each subject solved 200-600 mazes in any specific experiment below. There were four to six openings at the perimeter of the maze, of which four were labeled: one was the entry point and the remainder were potential exits marked by Arabic numerals. Starting at the entry point, in some mazes the path exited, whereas in others it terminated within the maze. Subjects were required to type the number corresponding to the true exit (if the path exited) or type zero (if

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15

Uekita, Tomoko, Akiko Ishibashi, and Toshiro Sakamoto. "Influence of Pre-Weaning Social Isolation on Post-Weaning Emotion Tendency and Mother–Infant Interactions in Infant Octodon Degus." International Journal of Environmental Research and Public Health 16, no. 10 (2019): 1824. http://dx.doi.org/10.3390/ijerph16101824.

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Our previous research using Octodon degus (degus) revealed that preweaning social isolation negatively affected object exploratory behavior. However, it remains unknown how social isolation affects animal psychology and other behaviors. The present study examined the effects of neonatal social isolation on degu emotion and mother–infant interactions before and after weaning. Because degus have a complex social repertoire, we predicted that they would be sensitive to social isolation and show similarities with humans in their social interaction. Pups in the isolation group were separated from t

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Naghibi, Bijan, and Farhoud Rayatnia. "Co-Administration of Subeffective Anxiolytic Doses of Diazepam and Hydroxyzine in Elevated Zero-Maze in Mice." Psychiatry Investigation 8, no. 2 (2011): 169. http://dx.doi.org/10.4306/pi.2011.8.2.169.

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17

Pähkla, Rein, Ants Kask, and Lembit Rägo. "Differential Effects of Beta-Carbolines and Antidepressants on Rat Exploratory Activity in the Elevated Zero-Maze." Pharmacology Biochemistry and Behavior 65, no. 4 (2000): 737–42. http://dx.doi.org/10.1016/s0091-3057(99)00265-8.

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18

Cook, Melloni N., Robert W. Williams, and Lorraine Flaherty. "Anxiety-related behaviors in the elevated zero-maze are affected by genetic factors and retinal degeneration." Behavioral Neuroscience 115, no. 2 (2001): 468–76. http://dx.doi.org/10.1037/0735-7044.115.2.468.

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19

Akash, Akash, Ritu Rani, Ajeet Pal Singh, and Amar Pal Singh. "Animals Use to Find Anxiolytic Activity: An Updated Review with Advantage of Each Model." Journal of Drug Delivery and Therapeutics 14, no. 3 (2024): 210–17. http://dx.doi.org/10.22270/jddt.v14i3.6488.

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Anxiety affects both humans and animals in profound ways, and understanding its psychological and biological components is essential to the development of anxiolytic medications. Animal models are utilized as simulations to explain emotional activities and as screening tools in anxiety research. Rats are the animal model used most often; mice, a more genetically flexible mammal, do less well in animal models. Behavioral investigations need careful consideration of changeable characteristics related to handling, climate, or models. To help us better understand the neurobiological elements of an

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20

Matrov, Denis, Kadri Kõiv, Margus Kanarik, Krista Peet, Karita Raudkivi, and Jaanus Harro. "Middle-range exploratory activity in adult rats suggests higher resilience to chronic social defeat." Acta Neuropsychiatrica 28, no. 3 (2015): 125–40. http://dx.doi.org/10.1017/neu.2015.64.

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ObjectiveStressful life events play an important role in the aetiology of human mood disorders and are frequently modelled by chronic social defeat (SD) in rodents. Exploratory phenotype in rats is a stable trait that is likely related to inter-individual differences in reactivity to stress. The aim of the study was to confirm that low levels of exploratory activity (LE) are, in rodents, a risk factor for passive stress coping, and to clarify the role of medium (ME) and high (HE) exploratory disposition in the sensitivity to SD.MethodsWe examined the effect of SD on male Wistar rats with LE, M

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21

Sestakova, Natalia, Angelika Puzserova, Michal Kluknavsky, and Iveta Bernatova. "Determination of motor activity and anxiety-related behaviour in rodents: methodological aspects and role of nitric oxide." Interdisciplinary Toxicology 6, no. 3 (2013): 126–35. http://dx.doi.org/10.2478/intox-2013-0020.

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ABSTRACT In various areas of the bio-medical, pharmacological and psychological research a multitude of behavioural tests have been used to investigate the effects of environmental, genetic and epi-genetic factors as well as pharmacological substances or diseased states on behaviour and thus on the physiological and psycho-social status of experimental subjects. This article is reviewing the most frequently used behavioural tests in animal research (open field, elevated plus maze, zero maze, and black and white box). It provides a summary of common characteristics as well as differences in the

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Heredia, Luis, Margarita Torrente, José L. Domingo, and María T. Colomina. "Individual housing and handling procedures modify anxiety levels of Tg2576 mice assessed in the zero maze test." Physiology & Behavior 107, no. 2 (2012): 187–91. http://dx.doi.org/10.1016/j.physbeh.2012.06.021.

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23

Díaz-Morán, Sira, Celio Estanislau, Toni Cañete, et al. "Relationships of open-field behaviour with anxiety in the elevated zero-maze test: Focus on freezing and grooming." World Journal of Neuroscience 04, no. 01 (2014): 1–11. http://dx.doi.org/10.4236/wjns.2014.41001.

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24

Lightowler, S., P. Goetghebeur, S. P. Vickers, M. J. Bickerdike, and G. A. Kennett. "Tolerance to the anxiogenic-like effect of mCPP in the rat elevated zero-maze test after subchronic administration." European Neuropsychopharmacology 10 (September 2000): 354. http://dx.doi.org/10.1016/s0924-977x(00)80459-9.

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25

Minter, Ross, and Katheleen J. Gardiner. "Trisomy of Human Chromosome 21 Orthologs Mapping to Mouse Chromosome 10 Cause Age and Sex-Specific Learning Differences: Relevance to Down Syndrome." Genes 12, no. 11 (2021): 1697. http://dx.doi.org/10.3390/genes12111697.

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Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), is the most common genetic cause of intellectual disability. The Dp10(1)Yey (Dp10) is a mouse model of DS that is trisomic for orthologs of 25% of the Hsa21 protein-coding genes, the entirety of the Hsa21 syntenic region on mouse chromosome 10. Trisomic genes include several involved in brain development and function, two that modify and regulate the activities of sex hormones, and two that produce sex-specific phenotypes as null mutants. These last four are the only Hsa21 genes with known sexually dimorphic properties. Relatively lit

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Bickerdike, Michael J., Charles A. Marsden, Colin T. Dourish, and Allan Fletcher. "The influence of 5-hydroxytryptamine re-uptake blockade on CCK receptor antagonist effects in the rat elevated zero-maze." European Journal of Pharmacology 271, no. 2-3 (1994): 403–11. http://dx.doi.org/10.1016/0014-2999(94)90800-1.

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27

MATTO, V., J. HARRO, and L. ALLIKMETS. "The Effects of Cholecystokinin A and B Receptor Antagonists on Exploratory Behaviour in the Elevated zero-maze in Rat." Neuropharmacology 36, no. 3 (1997): 389–96. http://dx.doi.org/10.1016/s0028-3908(97)00011-7.

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28

Alqurashi, Ghofran Khalid, Emad A. Hindi, Mohamed A. Zayed, et al. "The Impact of Chronic Unpredictable Mild Stress-Induced Depression on Spatial, Recognition and Reference Memory Tasks in Mice: Behavioral and Histological Study." Behavioral Sciences 12, no. 6 (2022): 166. http://dx.doi.org/10.3390/bs12060166.

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Depression-induced cognitive impairment has recently been given more attention in research. However, the relationship between depression and different types of memory is still not clear. Chronic unpredictable mild stress (CUMS) is a commonly used animal model of depression in which animals are exposed to chronic unpredictable environmental and psychological stressors, which mimics daily human life stressors. This study investigated the impact of different durations of CUMS on various types of memory (short- and long-term spatial memory and recognition memory) and investigated CUMS’ impact on t

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Sriramula, Srinivas, Drew Theobald, Rohan Umesh Parekh, Shaw M. Akula, Dorcas P. O’Rourke, and Jeffrey B. Eells. "Emerging Role of Kinin B1 Receptor in Persistent Neuroinflammation and Neuropsychiatric Symptoms in Mice Following Recovery from SARS-CoV-2 Infection." Cells 12, no. 16 (2023): 2107. http://dx.doi.org/10.3390/cells12162107.

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Evidence suggests that patients with long COVID can experience neuropsychiatric, neurologic, and cognitive symptoms. However, these clinical data are mostly associational studies complicated by confounding variables, thus the mechanisms responsible for persistent symptoms are unknown. Here we establish an animal model of long-lasting effects on the brain by eliciting mild disease in K18-hACE2 mice. Male and female K18-hACE2 mice were infected with 4 × 103 TCID50 of SARS-CoV-2 and, following recovery from acute infection, were tested in the open field, zero maze, and Y maze, starting 30 days po

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Anamika P K, Sulaiman Mohammed Alnasser, and Abdul Khayum K. "Experimental evaluation of anxiolytic activity in mice using Vacha Churanam." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 2520–26. http://dx.doi.org/10.26452/ijrps.v11ispl4.4507.

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Vacha Churanam is an Ayurvedic product. It is commonly given traditionally for memory enhancement, antidepressants, anxiolytic and anti-stress. However, there is no scientific evidence for its anxiolytic activity. Therefore the current study is aimed to validate its anxiolytic activity. Kept mice persuaded the anxiety in the room maintained with a temperature of 40C for two h per day. The Vacha Churanam has administrated doses of 200 and 400 mg/kg, p.o for 21 days. The behavioural parameters such as elevated zero maze, light-dark test, Morris water maze, actophtometer, hole board were produced

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Ali, Sayyad, Muhammad Hassham Hassan Bin Asad, Fahad Khan та ін. "Biological Evaluation of Newly Synthesized Biaryl Guanidine Derivatives to Arrest β-Secretase Enzymatic Activity Involved in Alzheimer’s Disease". BioMed Research International 2020 (11 травня 2020): 1–11. http://dx.doi.org/10.1155/2020/8934289.

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Proteases BACE1 (β-secretases) enzymes have been recognized as a promising target associated with Alzheimer’s disease (AD). This study was carried out on the principles of molecular docking, chemical synthesis, and enzymatic inhibition of BACE1 enzymes via biaryl guanidine-based ligands. Based on virtual screening, thirteen different compounds were synthesized and subsequently evaluated via in vitro and in vivo studies. Among them, 1,3-bis(5,6-difluoropyridin-3-yl)guanidine (compound (9)) was found the most potent (IC50=97±0.91 nM) and active to arrest (99%) β-secretase enzymes (FRET assay). F

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Risling, Tara E., Åsa Fahlman, Nigel A. Caulkett, and Susan Kutz. "Physiological and behavioural effects of hypoxemia in reindeer (Rangifer tarandus) immobilised with xylazine-etorphine." Animal Production Science 51, no. 4 (2011): 355. http://dx.doi.org/10.1071/an10190.

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This study examined the physiological effects of xylazine-etorphine (XE) immobilisation in reindeer (Rangifer tarandus), as well as post-immobilisation recovery and behaviour. Six reindeer weighing 105 ± 18 kg (mean ± s.d.) were immobilised via remote delivery of XE into the hind limb musculature. The animals were immobilised for 30 min on two separate occasions, and a randomised crossover design was used to assign nasal oxygen (O2) or unsupplemented air to each animal. Arterial blood gases were collected and analysed at zero (time of arterial catheter placement), 5, 10, 20 and 30 min. Heart r

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Demby, Tamar, G. William Rebeck, Christopher Albanese, Olga C. Rodriguez, Yichien Lee, and Jeanne Mandelblatt. "3367 A Mouse Model of APOE Genotype in Chemotherapy Related Cognitive Impairment." Journal of Clinical and Translational Science 3, s1 (2019): 1. http://dx.doi.org/10.1017/cts.2019.6.

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OBJECTIVES/SPECIFIC AIMS: Chemotherapy-related cognitive impairment (CRCI) affects 15-35% of breast cancer survivors and constitutes a significant challenge for survivor quality of life. Among older breast cancer survivors who received chemotherapy treatment, carriers of at least one ɛ4 allele of the APOE gene, which encodes apolipoprotein E, are at higher risk for developing CRCI than non-carriers. APOE4 is well characterized as the strongest genetic risk factor for Alzheimer’s disease, but how it contributes to CRCI is not yet understood, and no animal models of APOE genotype and CRCI have y

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Monisola, Umarudeen Ajibola, and Khan Ferhat. "Preclinical Research Tool Innovation in Resource-scarce Setting – A Case Study of a Mouse Anxiety Multi-test Appararus." Journal of Scientific Research and Reports 29, no. 8 (2023): 65–74. http://dx.doi.org/10.9734/jsrr/2023/v29i81774.

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One of the factors responsible for the high prevalence and attendant socio-economic burden of anxiety disorders is the paucity and slow pace of discovery of new anxiolytic drugs to complement or replace the existing ones due to high attrition rates and poor translation of preclinical anxiolytic drug discovery efforts to clinical usage. This scenario is viewed to arise from certain factors including the inherent anxiety sensitivity idiosyncrasies of most used individual classical anxiety tests/models when used as single assays. This thrust of this study is to invent a mouse multi-test that will

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Lippi, Stephen L. P. "Chronic Mild Unpredictable Stress and High-Fat Diet Given during Adolescence Impact Both Cognitive and Noncognitive Behaviors in Young Adult Mice." Brain Sciences 11, no. 2 (2021): 260. http://dx.doi.org/10.3390/brainsci11020260.

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Stress and diet are intricately linked, and they often interact in a negative fashion. Increases in stress can lead to poor food choices; adolescence is a period that is often accompanied by increased levels of stress. Stress and poor dietary choices can affect learning and memory; it is important to understand their combined effects when occurring during crucial developmental periods. Here, we present evidence that chronic mild unpredictable stress (CMUS) and high-fat diet (HFD) impact both cognitive and noncognitive behaviors when assessed after four weeks of manipulation in four-week old mi

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Li, Yong, and Jimok Kim. "CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory." Neural Plasticity 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/9817089.

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Neurocognitive effects of cannabinoids have been extensively studied with a focus on CB1 cannabinoid receptors because CB1 receptors have been considered the major cannabinoid receptor in the nervous system. However, recent discoveries of CB2 cannabinoid receptors in the brain demand accurate determination of whether and how CB2 receptors are involved in the cognitive effects of cannabinoids. CB2 cannabinoid receptors are primarily involved in immune functions, but also implicated in psychiatric disorders such as schizophrenia and depression. Here, we examined the effects of CB2 receptor knock

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37

Troelsen, K. B., C. Mathiesen, and N. R. Mirza. "P.4.f.001 Antiepileptics with diverse mechanisms of action are effective in the mouse zero maze model of anxiety-like behaviour." European Neuropsychopharmacology 17 (October 2007): S525. http://dx.doi.org/10.1016/s0924-977x(07)70811-8.

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Troelsen, K. B., E. Ø. Nielsen, and N. R. Mirza. "Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter." Psychopharmacology 181, no. 4 (2005): 741–50. http://dx.doi.org/10.1007/s00213-005-0032-5.

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Mendella, PD, SC Corey, A. Moore, L. Stanford, PA Campagnaro, and RE Brown. "8-OH-DPAT differentially influences two measures of anxiety: ultrasonic vocalizations and behaviour in the elevated zero maze, in 18 day old rats." Behavioural Pharmacology 8, no. 6 (1997): 657. http://dx.doi.org/10.1097/00008877-199711000-00057.

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40

López-Taboada, Isabel, Silvia Arboleya, Saúl Sal-Sarria, Miguel Gueimonde, Héctor González-Pardo, and Nélida M. Conejo. "Combined Effects of Early Life Stress and Prolonged Exposure to Western Diet on Emotional Responses and Gut Microbiota." Psicothema 36, no. 2 (2024): 133–44. http://dx.doi.org/10.7334/psicothema2023.287.

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Background:: Exposure to early life stress (ELS) and maternal consumption of a high-fat and high-sugar diet can have detrimental effects on adult emotional responses. The microbiota and gut-brain axis have been proposed as playing a mediating role in the regulation of stress and emotion. Method:: Young male rats were exposed to maternal separation (MS) together with maternal and postnatal consumption of a HFS diet (45%kcal saturated fat, 17%kcal sucrose). Anxiety-like behaviour was evaluated using an elevated zero-maze, and depression-like behaviour using the forced-swim and sucrose preference

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Bekci, Eren, Ramazan Can Gokmen, Lutfiye Kanit, et al. "Enhanced Novel Object Recognition and Spatial Memory in Rats Selectively Bred for High Nicotine Preference." Brain Sciences 14, no. 5 (2024): 427. http://dx.doi.org/10.3390/brainsci14050427.

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This study examined the influence of genetic background on cognitive performance in a selectively bred high nicotine-preferring (NP) rat line. Using the novel object recognition (NOR), novel location recognition (NLR), and Morris water maze (MWM) tests, we evaluated object memory, spatial memory, and spatial navigation in nicotine-naive NP rats compared to controls. Our results demonstrate that in the NOR test, both male and female NP rats spent more time exploring the novel object (higher discrimination index) compared to sex-matched controls. In the NLR, the discrimination index differed sig

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Shyu, Bai Chuang, Alan BH He, Ying H. Yu, and Andrew Chih Wei Huang. "Tricyclic antidepressants and selective serotonin reuptake inhibitors but not anticonvulsants ameliorate pain, anxiety, and depression symptoms in an animal model of central post-stroke pain." Molecular Pain 17 (January 2021): 174480692110633. http://dx.doi.org/10.1177/17448069211063351.

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Background Central post-stroke pain (CPSP) is a type of neuropathic pain caused by dysfunction in the spinothalamocortical pathway. However, no animal studies have examined comorbid anxiety and depression symptoms. Whether the typical pharmacological treatments for CPSP, which include antidepressants, selective serotonin reuptake inhibitors (SSRIs), and anticonvulsants, can treat comorbid anxiety and depression symptoms in addition to pain remains unclear? The present study ablated the ventrobasal complex of the thalamus (VBC) to cause various CPSP symptoms. The effects of the tricyclic antide

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Shin, Min, Madhavi Pandya, Kristan Espinosa, et al. "Istradefylline Mitigates Age-Related Hearing Loss in C57BL/6J Mice." International Journal of Molecular Sciences 22, no. 15 (2021): 8000. http://dx.doi.org/10.3390/ijms22158000.

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Age-related hearing loss (ARHL) is the most common sensory disorder among older people, and yet, the treatment options are limited to medical devices such as hearing aids and cochlear implants. The high prevalence of ARHL mandates the development of treatment strategies that can prevent or rescue age-related cochlear degeneration. In this study, we investigated a novel pharmacological strategy based on inhibition of the adenosine A2A receptor (A2AR) in middle aged C57BL/6 mice prone to early onset ARHL. C57BL/6J mice were treated with weekly istradefylline (A2AR antagonist; 1 mg/kg) injections

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Obradović, Lj Aleksandar, Srđan Joksimović, Michael M. Poe, Tamara Timić, James M.Cook, and Miroslav M. Savić. "Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats." Acta Veterinaria 64, no. 2 (2014): 189–99. http://dx.doi.org/10.2478/acve-2014-0018.

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Abstract The complex clinical picture of mono-neuropathy following injury of peripheral nerve is often accompanied by changes in the patients’ affective states. It has been shown that positive allosteric modulators of GABAA receptors can decrease nociceptive transmission in animal pain models. However, recent findings suggest a possibility that at least some of the antinociceptive effects of benzodiazepines, related to neuropathic painful stimuli, may to a significant degree be a consequence of their anxiolytic action. In this study we evaluated the possible delayed effects of SH-I-048A, a new

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Paton, Kelly F., Sheein Hong, Andrew Biggerstaff, and Bronwyn M. Kivell. "Sex Differences in the Behavioural Aspects of the Cuprizone-Induced Demyelination Model in Mice." Brain Sciences 12, no. 12 (2022): 1687. http://dx.doi.org/10.3390/brainsci12121687.

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Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis. However, despite significant demyelination, behavioural deficits may be subtle or have mixed results depending on the paradigm used. Furthermore, the sex differences within the model are not well understood. In the current study, we have sought to understand the behavioural deficits associated with the cuprizone-induced demyelination model in both male and female C57BL/6J mice.

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Zhou, Xinyi, Bifeng Wu, Wenhao Liu, et al. "Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice." Neuroscience Bulletin 37, no. 9 (2021): 1325–38. http://dx.doi.org/10.1007/s12264-021-00731-7.

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AbstractA strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk. In humans, a large proportion of mental disorders are accompanied by impairments in risk avoidance. One of the most important genes involved in mental disorders is disrupted-in-schizophrenia-1 (DISC1), and animal models in which this gene has some level of dysfunction show emotion-related impairments. However, it is not known whether DISC1 mouse models have an impairment in avoiding potential risks. In the present study, we used DISC1-N terminal truncation (DISC1-NTM) mice to

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Kühne, Stephanie, Martha Schalla, Tiemo Friedrich, et al. "Nesfatin-130-59 Injected Intracerebroventricularly Increases Anxiety, Depression-Like Behavior, and Anhedonia in Normal Weight Rats." Nutrients 10, no. 12 (2018): 1889. http://dx.doi.org/10.3390/nu10121889.

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Nesfatin-1 is a well-established anorexigenic peptide. Recent studies indicated an association between nesfatin-1 and anxiety/depression-like behavior. However, it is unclear whether this effect is retained in obesity. The aim was to investigate the effect of nesfatin-130-59—the active core of nesfatin-1—on anxiety and depression-like behavior in normal weight (NW) and diet-induced (DIO) obese rats. Male rats were intracerebroventricularly (ICV) cannulated and received nesfatin-130-59 (0.1, 0.3, or 0.9 nmol/rat) or vehicle 30 min before testing. Nesfatin-130-59 at a dose of 0.3 nmol reduced su

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Wang, Fan, Zheng Fangfang, Xiangmeng Guo, et al. "Effects of volatile organic compounds and carbon monoxide mixtures on learning and memory, oxidative stress, and monoamine neurotransmitters in the brains of mice." Toxicology and Industrial Health 34, no. 3 (2018): 178–87. http://dx.doi.org/10.1177/0748233717747504.

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In this study, we investigated the effect of inhaled mixtures of volatile organic compounds (VOCs) and carbon monoxide (CO) on neuroethology. Fifty 6-week-old male Kunming mice were exposed in five similar static chambers; zero (control) and four different doses of VOC and CO mixtures (G1–G4) for 10 consecutive days and 2 h/day. The compounds and concentrations were as follows: formaldehyde, benzene, toluene, xylene, and CO as 0.10 + 0.11 + 0.20 + 0.20 + 10.00 mg/m3, 0.20 + 0.22 + 0.40 + 0.40 + 20.00 mg/m3, 1.00 + 1.10 + 2.00 + 2.00 + 100.00 mg/m3, and 5.00 + 5.50 + 10.00 + 10.00 + 500.00 mg/m

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Irizarry-Méndez, Nashaly, Marangelie Criado-Marrero, Anixa Hernandez, Maria Colón, and James T. Porter. "Reducing FKBP51 Expression in the Ventral Hippocampus Decreases Auditory Fear Conditioning in Male Rats." International Journal of Molecular Sciences 25, no. 13 (2024): 7097. http://dx.doi.org/10.3390/ijms25137097.

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Fear conditioning evokes a physiologic release of glucocorticoids that assists learning. As a cochaperone in the glucocorticoid receptor complex, FKBP51 modulates stress-induced glucocorticoid signaling and may influence conditioned fear responses. This study combines molecular and behavioral approaches to examine whether locally reducing FKBP51 expression in the ventral hippocampus is sufficient to affect fear-related behaviors. We hypothesized that reducing FKBP51 expression in the VH would increase glucocorticoid signaling to alter auditory fear conditioning. Adult male rats were injected w

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Jensen, Per, Karin Schütz, and Christina Lindqvist. "RED JUNGLE FOWL HAVE MORE CONTRAFREELOADING THAN WHITE LEGHORN LAYERS: EFFECT OF FOOD DEPRIVATION AND CONSEQUENCES FOR INFORMATION GAIN." Behaviour 139, no. 9 (2002): 1195–209. http://dx.doi.org/10.1163/15685390260437335.

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AbstractContrafreeloading (CFL), i.e. choosing food which requires work over free food, occurs at a higher rate in red jungle fowl (Gallus gallus) compared to White Leghorn layers. We examined whether this difference between breeds was altered by food deprivation and whether it affected the information gained about alternative food sources. In a first experiment, twenty birds of each breed were deprived for zero, three and six hours and then allowed a choice of feeding from freely available food or food mixed with wood shavings. In both breeds, CFL tended to decrease after deprivation, but jun

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