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Journal articles on the topic 'Zero Order Release; Lag Time'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Janich, Christopher, Andrea Friedmann, Juliana Martins de Souza e Silva, et al. "Risperidone-Loaded PLGA–Lipid Particles with Improved Release Kinetics: Manufacturing and Detailed Characterization by Electron Microscopy and Nano-CT." Pharmaceutics 11, no. 12 (2019): 665. http://dx.doi.org/10.3390/pharmaceutics11120665.

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For parenteral controlled drug release, the desired zero order release profile with no lag time is often difficult to achieve. To overcome the undesired lag time of the current commercial risperidone controlled release formulation, we developed PLGA–lipid microcapsules (MCs) and PLGA–lipid microgels (MGs). The lipid phase was composed of middle chain triglycerides (MCT) or isopropylmyristate (IPM). Hydroxystearic acid was used as an oleogelator. The three-dimensional inner structure of Risperidone-loaded MCs and MGs was assessed by using the invasive method of electron microscopy with focused

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2

Vinogradov, V. P., and E. V. Blynskaya. "Optimization of the composition and technology for the production of flotation tablets of sitagliptin with modified release." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 4 (September 6, 2024): 19–30. http://dx.doi.org/10.33920/med-13-2404-02.

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The article presents the results of the study of the influence of critical material attributes and process parameters for obtaining modified release sitagliptin floating tablets, as well as the optimization of the factor values using the surface response method and the generalized desirability function. In accordance with the three-factor three-level Box-Behnken plan, the tests of dosage forms were carried out, the values of the quality attributes - «floating lag time», the coefficient of determination of compliance with the kinetics of the zero-order release model, total release, tablet hardn

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3

Shaheen, Shama*¹ Eisha Ganju² Rajni Dubey³ Bhaskar Kumar Gupta⁴. "Formulation and Characterization of Sustained-Release Microspheres of Oxazepam." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1480–87. https://doi.org/10.5281/zenodo.15202138.

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The aim of this study was to formulate and characterize oxazepam-loaded microspheres for sustained drug release to enhance its therapeutic efficacy in the treatment of anxiety and insomnia. Various formulations of microspheres were prepared using HPMC, ethyl cellulose (EC), and guar gum as polymers, and their physical properties, such as yield, drug entrapment efficiency, buoyancy, and floating lag time, were evaluated. The optimized formulation (F4) exhibited a high percentage yield (73.32±0.22%) and drug entrapment efficiency (72.23±0.32%). Furthermore, F4 showed the shortest f

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4

Koshta, Ashok, and Neelesh Malviya. "Formulation and Evaluation of Floating-pulsating Drug Delivery System containing Fixed-dose Combination for Chronotherapy of Hypertension." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1725–32. http://dx.doi.org/10.25258/ijddt.12.4.39.

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This project aims to build a floating, pulsatile hypertension therapy. This work examined the 3-factor, 2-level box-behnken design and optimization technique for the floating pulsatile tablet. The quantity of polyox WSR N12K and polyox WSR205 was chosen to be the independent variable. Drug release, lag time, and swelling index are chosen to function in terms of dependent variables. ANOVA was intended to assess the data statistically, and p-value of 0.05 was regarded to have statistical significance. The tablet containing bisoprolol fumarate (BF) and hydrochlorothiazide (HCTZ) was chosen for pr

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Dolas, Ramdas T., Shalindra Sharma, and Madhuraj Sharma. "FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF LAFUTIDINE." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 393–99. http://dx.doi.org/10.22270/jddt.v8i5.1898.

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The purpose of this research was to develop a novel gastroretentive drug delivery system based on wet granulation technique for sustained delivery of active agent. Quick GI transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to decreased efficacy of the administered dose and thus less patient compliance. Gastroretentive floating tablets, which was designed to provide the desired sustained and complete release of drug for prolonged period of time. Gastroretentive floating tablets of lafutidine were prepared by wet granulation technique

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Patel, Upasana J., Hitesh kumar A. Patel, Bhumika J. Limbachiya, and Mehzabeen Jhankhwala. "Formulation, development and optimization of gastroretentive floating pellets of febuxostat." Journal of medical pharmaceutical and allied sciences 11, no. 1 (2022): 4317–23. http://dx.doi.org/10.55522/jmpas.v11i1.2095.

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The aim of the study was to develop gastro retentive floating pellets of febuxostat used to treat gout condition which having low solubility and high bioavailability. The gastro retentive floating pellets of febuxostat were formulated using Gelucire 43/01 and ethyl cellulose as a sustain release polymer and microcrystalline cellulose as spheronizing agent by extrusion- spheronization technique. A 32 full factorial design was applied to investigate the effect of the two-independent variable, that is, ratio of Drug: Gelucire (X1) and ratio of Drug: ethyl cellulose (X2), on the dependent variable

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7

Jaiseri, Dareena, Supusson Pengnam, Praneet Opanasopit, et al. "Novel propranolol-loaded gastro-floating 3D-printed devices with zero-order release kinetics." Pharmacia 71 (December 19, 2024): 1–8. https://doi.org/10.3897/pharmacia.71.e133399.

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Currently, fused deposition modeling (FDM) is a 3D printing technology that has been most widely used to develop innovative drug delivery approaches for overcoming the limitations of oral drug administration. Propranolol has a short plasma half-life and is well soluble in acidic environments. Thus, this study aimed to develop a gastro-floating 3D printed device (GFD) to sustain the release of propranolol in the stomach as a gastro-retentive drug delivery system. The polylactic acid (PLA) was selected to fabricate the GFD. An air chamber was included in the interior construction of the GFD desi

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8

Jaiseri, Dareena, Supusson Pengnam, Praneet Opanasopit, et al. "Novel propranolol-loaded gastro-floating 3D-printed devices with zero-order release kinetics." Pharmacia 71 (December 19, 2024): 1–8. https://doi.org/10.3897/pharmacia.71.e133399.

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Currently, fused deposition modeling (FDM) is a 3D printing technology that has been most widely used to develop innovative drug delivery approaches for overcoming the limitations of oral drug administration. Propranolol has a short plasma half-life and is well soluble in acidic environments. Thus, this study aimed to develop a gastro-floating 3D printed device (GFD) to sustain the release of propranolol in the stomach as a gastro-retentive drug delivery system. The polylactic acid (PLA) was selected to fabricate the GFD. An air chamber was included in the interior construction of the GFD desi

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9

Shiv, Sagar Mahapatra*1 Akanksha Patel2 Manmath Purohit3. "Design Development And Evaluation Of Floating Drug Delivery System For Lornoxicam NSAID Drug." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 231–51. https://doi.org/10.5281/zenodo.10927489.

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Lornoxicam is one of the drugs used for the management of arthritic pain. The site of absorption of Lornoxicam is in the GIT and it has a short half life of 3-4 h. Therefore, the present investigation was concerned with the development of the floating matrix tablets, which after oral administration are designed to prolong the gastric residence time and thus, improve the bioavailability of the drug as well as its half life. Lornoxicam showed maximum absorption at wavelength at 374 nm in 0.1 N HCl. Drug-Polymer compatibility studies by FTIR gave conformation about their purity and showed no inte

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10

Patle, Bharti, Vivek Jain, Shradha Shende, and Prabhat Kumar Jain. "Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 445–50. http://dx.doi.org/10.22270/jddt.v9i4-s.3353.

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Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Prochlorperazine dimaleate (PCZ) were prepared by direct compression method using altered concentrations of HPMC K4,

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Jagdale, Swati C., Nilesh A. Bari, Bhanudas S. Kuchekar, and Aniruddha R. Chabukswar. "Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/801769.

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The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems of bisoprolol. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. The prepared system consisted of two parts: a core tablet containing the active ingredient and an erodible outer shell with gas generating agent. The rapid release core tablet (RRCT) was prepared by using superdisintegrants with active ingredient. Press coating of optimized RRCT was done by polymer. A 32full factorial design w

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12

Pravinkumar Darji, Jayendrakumar Patel, Shalin Parikh, et al. "Development of single layer osmotic controlled release tablet for low soluble drug: Single Core Osmotic Pump (SCOP)." World Journal of Advanced Research and Reviews 22, no. 2 (2024): 1006–20. http://dx.doi.org/10.30574/wjarr.2024.22.2.1488.

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A novel Single Core Osmotic Pump (SCOP) pill has been created to administer high doses of the low solubility medication Rifaximin using osmosis. The formulations were evaluated using six comparative parameters: Q24 (total release after 24 hours), Q12 (total release after 12 hours), TL (lag time), RSQzero12 (R square of the zero-order equation for drug release in 12 hours), RR12 (in vitro release rate for 12 hours), and T80% (time required to deliver 80% of the drug). The drug release profile from osmotic devices shows that the choice of polymer and its concentration in the core formulation can

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13

Pravinkumar, Darji, Patel Jayendrakumar, Parikh Shalin, et al. "Development of single layer osmotic controlled release tablet for low soluble drug: Single Core Osmotic Pump (SCOP)." World Journal of Advanced Research and Reviews 22, no. 2 (2024): 1006–20. https://doi.org/10.5281/zenodo.14607630.

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A novel Single Core Osmotic Pump (SCOP) pill has been created to administer high doses of the low solubility medication Rifaximin using osmosis. The formulations were evaluated using six comparative parameters: Q24 (total release after 24 hours), Q12 (total release after 12 hours), TL (lag time), RSQzero12 (R square of the zero-order equation for drug release in 12 hours), RR12 (in vitro release rate for 12 hours), and T80% (time required to deliver 80% of the drug). The drug release profile from osmotic devices shows that the choice of polymer and its concentration in the core formulation can

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14

Ahmad, Sher, Jamshaid Ali Khan, Tabassum Naheed Kausar, et al. "Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix Tablets for Enhanced Oral Bioavailability." Molecules 28, no. 6 (2023): 2606. http://dx.doi.org/10.3390/molecules28062606.

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The convenient and highly compliant route for the delivery of active pharmaceutical ingredients is the tablet. A versatile platform of tablets is available for the delivery of therapeutic agents to the gastrointestinal tract. This study aimed to prepare gastro retentive drug delivery floating tablets of silymarin to improve its oral bioavailability and solubility. Hydroxypropyl methylcellulose (HPMCK4M and HPMCK15), Carbopol 934p and sodium bicarbonate were used as a matrix, floating enhancer and gas generating agent, respectively. The prepared tablets were evaluated for physicochemical parame

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15

K., Venkateswara Reddy* Shimoga Nagaraj Sriharsha and S. Sujatha. "FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF TAPENTADOL HCL." IAJPS,CSK PUBLICATIONS 03, no. 12 (2016): 1461–69. https://doi.org/10.5281/zenodo.220872.

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The objective of the present study is to evaluate HPMC K100M, HPMC K15M and carbopol 934P as matrix formers in this design of floating tablets of tapentadol, a poorly water soluble drug. Floating tablet s of tapentadol (100 mg) were formulated employing (i) HPMC K100M (ii) HPMC K15M and (iii) Carbopol 934P as matrix formers at 30% and 50% strength, sodium bicarbonate at 7.5%, 10% & 12.5% strength as gas generating agent and the tablets were evaluated for floating and drug releases characteristics. Tapentadol floating tablets formulated employing HPMC K100M and HPMC K15M as matrix formers a

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16

Munagala Gayatri Ramya and Kothapalli Bannoth Chandra Sekhar. "Preparation and evaluation of matrix type gastro retentive floating atenolol tablets using sintering technique." International Journal of Research in Pharmaceutical Sciences 11, no. 2 (2020): 1920–26. http://dx.doi.org/10.26452/ijrps.v11i2.2109.

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The aim of this investigation was to design and assess the gastric floating tablets of Atenolol using thermal sintering and investigate the effect of sintering on PEO polymer. Atenolol is an Antihypertensive with only 50 percent bioavailability due to poor absorption in lower GI tract. Gastro retentive Floating tablets were prepared to enhance the gastric retention time, to prolong the drug release. PEO which was selected as sintered polymer. Tablets were prepared by direct compression method .Formulated tablets were exposed to different temperatures (400C, 500C and 600C) at various time inter

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17

Poornima, P* Abbulu K. Mukkanti K. "DESIGN AND EVALUATION OF GASTRORETENTIVE NIFEDIPINE FLOATING TABLETS IN THE TREATMENT OF HYPERTENSION." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4178–89. https://doi.org/10.5281/zenodo.1048997.

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Gastro retentive floating tablets of Nifedipine were prepared using various grades of HPMC as a release retarding agent. Nifedipine is a dihydropyridine derivative effectively used in the management of various cardiovascular diseases in long term therapy, the biological half life is only 2 hours. The main aim of the present study is to prolong the drug release upto 24 hours. The tablets were prepared by direct compression method and the formulations were evaluated different physic chemical and dissolution studies. The formulations from each polymer F6, F10 and F20 gave better controlled drug r

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18

Patel, Dasharath M., Divyesh K. Patel, and Chhagan N. Patel. "Formulation and Evaluation of Floating Oral In Situ Gelling System of Amoxicillin." ISRN Pharmaceutics 2011 (July 28, 2011): 1–8. http://dx.doi.org/10.5402/2011/276250.

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Purpose. Effective Helicobacter pylori eradication requires delivery of the antibiotic locally in the stomach. High dose of amoxicillin (750 to 1000 mg) is difficult to incorporate in floating tablets but can easily be given in liquid dosage form. Keeping the above facts in mind, we made an attempt to develop a new floating in situ gelling system of amoxicillin with increased residence time using sodium alginate as gelling polymer to eradicate H. pylori. Methods. Floating in situ gelling formulations were prepared using sodium alginate, calcium chloride, sodium citrate, hydroxypropyl methyl ce

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Kapil, Jalodiya, Jain Sourabh, and Shukla Karunakar. "Formulation and evaluation of gastro-retentive floating tablets of terbinafine." GSC Biological and Pharmaceutical Sciences 13, no. 1 (2020): 257–66. https://doi.org/10.5281/zenodo.4264695.

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Gastro-retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal tract and improve the bioavailability of medications those are characterized by a narrow absorption window. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of terbinafine were prepared by direct compression method using altered conc

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P, Poornima, Abbulu K, and Mukkanti K. "Development and In Vitro – In Vivo Evaluation of Gastro-retentive Floating Tablets Containing Repaglinide." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 2 (2018): 4026–36. http://dx.doi.org/10.37285/ijpsn.2018.11.2.4.

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The present investigation concerns the development of the repaglinide floating matrix tablets, which after oral administration are designed to prolong the gastric residence time, increase the drug bioavailability and diminish the side effects of irritating drugs. FTIR studies revealed that there is no interaction between the drug and polymers used for the formulation. Among all the formulations F21 containing HPMC K1500 PH PRM, Polyox WSR-303 and Sodium bicarbonate, as gas generating agent was selected as optimized formulation based on physico chemical properties, floating lag time (36 sec) an

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Rajguru, Shreya Ajay, Maimuna Fatima, Hemanth kumar Bandaru, Shaik Farooq Ahmed Ahmed, VIPANCHI Veeranti, and Prasanthi Domaraju. "Pulsatile Tablet of Famotidine Using Core in Cup Method." Journal of Pharmacy 3, no. 1 (2023): 27–37. https://doi.org/10.31436/jop.v3i1.190.

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Introduction: The present work aims to formulate pulsatile delivery system using “core-in-cup” system for Famotidine, a H2 receptor antagonist used for duodenal ulcer, benign gastric ulcers, GERD and nocturnal acid breakthrough (A physiological condition where there is sudden surge of gastric acidity at midnight). In such situation, pulsatile release of drug is preferable having lag time of 3-4 hrs. Materials and method: Core tablets were prepared by employing direct compression method using HPMC K4M, sodium bicarbonate and MCC. Ethyl cellulose, HPMC K4M and Xanthan gum were used for preparati

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Baratam, S. R., and V. R. Jayanthi. "PREPARATION AND EVALUATION OF FLOATING MATRIX SYSTEM OF LEVOFLOXACIN HEMIHYDRATE TABLETS." INDIAN DRUGS 55, no. 08 (2018): 67–70. http://dx.doi.org/10.53879/id.55.08.11181.

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Gastro floating drug delivery system (GFDDS) of Levofloxacin hemihydrate (LVF), category of Quinoline antibiotic used to treat Helicobacter pylori infection. The aim of the study was to develop a Floating matrix system (FDDS) of LVF for sustained release to improve the extended retention in stomach and local site specific action in the stomach. Preparation of LVF tablets using wet granulation method using HPMC K4M with Sodium bicarbonate as effervescent agent. All formulations were developed and evaluated for Floating properties for swelling characteristics and in vitro drug release studies. I

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Hasan, Ikramul, Tushar Saha, and Md Selim Reza. "Preparation and In-vitro Characterization of Gastroretentive Floating Tablets of Domperidone." Bangladesh Pharmaceutical Journal 22, no. 2 (2019): 170–75. http://dx.doi.org/10.3329/bpj.v22i2.42300.

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The present investigation was design for domperidone floating table preparation and in-vitro characterization. The ultimate target was increasing gastric retention by means of floatability of the tablet. Hydrophilic cellulosic polymers, Methocel K15M and Methocel K100M were used in this experiment for achieving release controlling property. Sodium bicarbonate played the key role of floatation by generating gas. Direct compression was the method of choice for preparing the tablets. The tablets were evaluated for physical parameters, buoyancy study, total floating time determination and dissolut

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Thakur, Shobhana, Dolly Jain, and Shiv Kumar Prajapati. "DEVELOPMENT AND CHARACTERIZATION OF SUSTAINED RELEASE GASTRO-RETENTIVE FLOATING TABLETS OF AMBROXOL HYDROCHLORIDE." INTERNATIONAL JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (IJPER) 4, no. 1 (2022): 43–49. http://dx.doi.org/10.37021/ijper.v4i1.6.

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Introduction: The objective of this study was to formulate floating tablets of Ambroxyl hydrochloride (AMB HCl) using the dry granulation technique to increase its bioavailability and the gastric residence time (GRT) of the dosage form. Materials and Methods: The gastro-retentive floating tablets of Ambroxol hydrochloride (AMB HCl) were prepared by direct compression method using different concentrations of polymers such as HPMC K4, HPMC K15 and PVP K30, gas releasing agents (Sodium bicarbonate and citric acid) and diluents (Microcrystalline cellulose). Citric acid was also used as an antioxid

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Shubham, Solanke* Hemant Sawarkar Aijaz Sheikh Kailash Biyani. "Design And Characterization of Gastroretentive Drug Delivery System of a Model Drug." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 734–37. https://doi.org/10.5281/zenodo.15596005.

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This study focused on developing a gastroretentive drug delivery system (GRDDS) for lamotrigine, an antiepileptic drug, using floating tablets formulated with curdlan gum and hydroxypropyl methylcellulose (HPMC K100M) as matrix-forming polymers, alongside sodium bicarbonate as a gas-generating agent. The objective was to enhance gastric retention and achieve sustained drug release. Eight formulations (F1–F4 with curdlan gum, F5–F8 with HPMC K100M) were prepared via direct compression and evaluated for physicochemical properties, buoyancy, swelling, in-vitro drug release, kinetics,

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Srilatha, Ch, and T. Giriraj kulkarni. "Formulation and Evaluation of Colon Targeted Ciprofloxacin Microspheres." Trends in Pharmaceuticals and Nanotechnology 5, no. 2 (2023): 31–40. http://dx.doi.org/10.46610/tpnt.2023.v05i02.004.

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In the present study, Colon-targeted Ciprofloxacin hydrochloride microspheres were formulated and their in vitro properties were assessed to determine whether or not the antibiotic could be delivered to the colon. By utilizing span-80 as an emulsifying agent, ciprofloxacin hydrochloride microspheres for colon targeting were prepared using the emulsion-solvent evaporation method. According to the preliminary trial findings, the ratio of drug to polymer had an impact on the microspheres' properties. The Ciprofloxacin: Eudragit S-100+HPMC 6cps ratio of 1:1, 1:2, 1:3, 1:4, 1:5, and 1:6 were used t

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Parashar, Tarun, and Nardev Singh. "FORMULATION AND IN VITRO EVALUATION OF BILAYER TABLET OF ATENOLOL FOR BIPHASIC DRUG RELEASE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 114. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.22975.

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Objective: In the present research work, the aim was to prepare the bilayer tablet of atenolol for biphasic drug release to improve its bioavailability and absorption in the lower gastrointestinal tract. Methods: In the formulation of immediate release crospovidone, croscarmellose sodium, and sodium starch glycolate was used as super disintegrate and was directly compressed. For a sustained release portion different grade hydroxypropyl methylcellulose (HPMC) K4M, HPMC K15M, gum tragacanth, gum acacia, guar gum, and ethyl cellulose. Preformulation studies were performed before compression. The

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Kumar, Servesh, and Vishal Soni. "Formulation, Development and Characterization of Sustained Release Formulation of Herbal Extracts." Asian Pacific Journal of Health Sciences 9, no. 2 (2022): 273–76. http://dx.doi.org/10.21276/apjhs.2022.9.2.54.

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Aim: The aim of the present investigation is to design of sustained release dosage form of different extracts that will help in releasing only small quantities of drug over a prolonged period of time. Material and Methods: The different ingredients for formulations are given as in Table 1 below. The measured quantities of drug, HPMC, MCC and NaHCO3 were mixed thoroughly using a mortar and pistil. The granules were punched into tablets using direct compression technique. The blank formulation (or) placebo (HPMC+ MCC+NaHCO3) and polyherbal formulation were also tested using FTIR Spectrometer. Th

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Karim, Abdul, Muhammad Ashraf Shaheen, Tahir Mehmood, Abdul Rauf Raza, Musadiq Aziz, and Badar Din. "Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation." Journal of Chemistry 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/6924601.

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The float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS). A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT) as a model drug and formulations have been prepared utilizing 32factorial designs. The drug release (DR) data has been subjected to various kinetic models to investigate the DR mechanism. A reduction in rate has been observed by expanding the amounts of PSG and LSG parts, while an expansion has been noted by increa

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Naveen, Kumar HR, Kumar P. Ashok, V. Kulkarni Suresh, and K. Manjunath. "Development and Evaluation of Floating Sustained Release Bilayer Tablets Containing Drotaverine HCl." American Journal of PharmTech Research 12, no. 06 (2022): 62–74. https://doi.org/10.5281/zenodo.7407644.

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ABSTRACT Bilayer floating tablets of Drotaverine HCL were developed by direct compression method. Immediate release layer contains 20 mg of drug and super disintegrant sodium starch glycolate, serves the purpose of loading dose. Sustained release layer contained HPMC K100, natural polymers like xanthan gum, guar gum, karaya gum release the drug for 12 hours’ time. Sodium bicarbonate and citric acid are used to produce effervescence. Floating lag time of optimized tablet is 92 sec, whereas floating duration is more than 12 hours. FTIR results revealed that there was no interaction between

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Kapil Jalodiya, Sourabh Jain, and Karunakar Shukla. "Formulation and evaluation of gastro-retentive floating tablets of terbinafine." GSC Biological and Pharmaceutical Sciences 13, no. 1 (2020): 257–66. http://dx.doi.org/10.30574/gscbps.2020.13.1.0310.

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Gastro-retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal tract and improve the bioavailability of medications those are characterized by a narrow absorption window. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of terbinafine were prepared by direct compression method using altered conc

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Pathan, Vasim, Vishal Gulecha, Amar Zalte, and Anil Jadhav. "Design, Development, Formulation, and Evaluation of Gastro retentive Floating Tablet for Anti-diabetic Agent." Asian Pacific Journal of Health Sciences 8, no. 4 (2021): 1–12. http://dx.doi.org/10.21276/apjhs.2021.8.4.1.

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The main aim of the research was to persist the gastric residence time of vildagliptin by designing its gastro-retentive tablet as well as to study the effect of different polymers on its release rate using 23 randomized full factorial designs. Tablets are manufactured by direct compression method. Hydroxypropyl methylcellulose was used as matrixing agent, M.C.C., and Na2Co3 were used. The manufactured tablets assessed for physicochemical parameters such as weight variety, hardness, friability, floating properties (total floating time and floating lag time), in vitro drug release, and drug con

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Baratam, Srinivasa Rao, and Vijayaratna J. "FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF LEVOFLOXACIN HEMIHYDRATE USING HYDROXYPROPYL METHYLCELLULOSE K4M TO TREAT HELICOBACTER PYLORI INFECTION." Asian Journal of Pharmaceutical and Clinical Research 11, no. 6 (2018): 148. http://dx.doi.org/10.22159/ajpcr.2018.v11i6.20296.

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Objective: The aim of the study was to develop a floating drug delivery system of levofloxacin (LVF) hemihydrate for sustained drug delivery to improve the extended retention in the stomach, oral bioavailability, and local site-specific action in the stomach. Methods: Preparation of LVF tablets using melt granulation method using hydroxypropyl methylcellulose (HPMC) K4M with sodium bicarbonate as gas generating agent. From LFTA1 to LFTA5, formulations were developed and evaluated for floating properties for swelling characteristics and in vitro drug release studies. In vitro dissolution was ca

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Kasperek, Regina, and Wiktor Czarnecki. "Effect of hydrophilic substances on liberation of quinidine from starch—methylcellulose spheres." Scientia Pharmaceutica 72, no. 4 (2004): 293–308. http://dx.doi.org/10.3797/scipharm.aut-04-25.

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The spheres were prepared by the desolvation technique combined with gravitational sedimentation of droplets of methylcellulose gel suspensions with the addition of 25% quinidine adsorbate on the potato starch and 5% hydrophilic agents such as Span 80, Tween 60, glyceryl monostearate or PEG 2000 instilled into a desolvation liquid (saturated sodium acetate:paraffin liquid:heptane 1:1:1, v/v/v) through a standardized capillary.As follows from the physicochemical studies the sphericity (Sp) changed within the range 1.020–1.314, the porosity (P) was 19.1–66.5% and the loading efficiency was 35.10

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Shweta, Negi*1 Vikas Dhawan2. "Design, Development And Evaluation Of Tolperisone HCL Floating Matrix Tablets." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 667–70. https://doi.org/10.5281/zenodo.10837434.

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The aim of present investigation was undertaken with the objective of formulating buoyant tablet of Tolperisone HCl. Tolperisone HCl is a skeletal muscle relaxant. Drug is more stable in acidic medium (pH < 4.5), and in alkaline medium (pH 4 to 7) tolperisone breaks downinto4-MMPPO[2methyl-1-(4methylphenyl)-propanone]  and  piperidine.  Thus,  the  patient  is  exposed  to  an uncontrollable  quantity  of  genotoxic  agent  4-MMPPO.  32  full  factorial  designs  were  used  for optimiza

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Reddy, Arun, and Narendar Reddy. "Development of Multiple-Unit Floating Drug Delivery System of Clarithromycin: Formulation, in vitro Dissolution by Modified Dissolution Apparatus, in vivo Radiographic Studies in Human Volunteers." Drug Research 67, no. 07 (2017): 412–18. http://dx.doi.org/10.1055/s-0043-102952.

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AbstractClarithromycin (CM), a broad spectrum macrolide antibiotic used to eradicate H. pylori in peptic ulcer. Clarithromycin (CM) is well absorbed from the gastrointestinal tract, but has a bioavailability of 50% due to rapid biodegradation. The aim of this investigation was to increase the gastric residence time, and to control the drug release of clarithromycin by formulating into multiple unit floating mini-tablets. Floating tablets were prepared by using direct compression method with HPMC K4M and Polyox WSR 1105 as release retarded polymers and sodium bicarbonate as gas generating agent

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S.K, Ghate Dr. D.M.Sakarkar. "DEVELOPMENT AND EVALUATION OF OSMOTICALLY CONTROLLED ORAL DRUG DELIVERY SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 459–70. https://doi.org/10.5281/zenodo.1036415.

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Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain mole

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Yan, Xieguo, Shiqiang Wang, and Kaoxiang Sun. "Long-Acting Risperidone Dual Control System: Preparation, Characterization and Evaluation In Vitro and In Vivo." Pharmaceutics 13, no. 8 (2021): 1210. http://dx.doi.org/10.3390/pharmaceutics13081210.

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Schizophrenia, a psychiatric disorder, requires long-term treatment; however, large fluctuations in blood drug concentration increase the risk of adverse reactions. We prepared a long-term risperidone (RIS) implantation system that can stabilize RIS release and established in-vitro and in-vivo evaluation systems. Cumulative release, drug loading, and entrapment efficiency were used as evaluation indicators to evaluate the effects of different pore formers, polymer ratios, porogen concentrations, and oil–water ratios on a RIS implant (RIS-IM). We also built a mathematical model to identify the

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Israr, Muhammad, Nicola Pugliese, Arshad Farid, et al. "Preparation and Characterization of Controlled-Release Floating Bilayer Tablets of Esomeprazole and Clarithromycin." Molecules 27, no. 10 (2022): 3242. http://dx.doi.org/10.3390/molecules27103242.

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Controlled-release effervescent floating bilayer tablets reduce dosage frequency and improve patient compliance with enhanced therapeutic outcomes. Generally, two different tablets of clarithromycin and esomeprazole, respectively, are given for the treatment of Helicobacter pylori infection and it might be worth incorporating both in a single tablet. In the current study, controlled-release floating bilayer tablets of clarithromycin and esomeprazole (F1–F4) were developed with different rates of polymeric materials by a direct compression method. During the formulation, Fourier-transform infra

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Dr N Swathi, Dr N. Swathi, J. Madhuritha J. Madhuritha, K. Anusha K. Anusha, S. Kavya S. Kavya, Ch Leena Ch. Leena, and V. Poojitha V. Poojitha. "Formulation and in-vitro evaluation of Gastro retentive floating tablets of Cefixime Trihydrate by using Natural Polymers." International Journal of Pharmaceutical Science Invention 14, no. 3 (2025): 35–46. https://doi.org/10.35629/6718-14033546.

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The Floating drug delivery system is a novel approach in the Gastro retentive drug delivery systems (GRDDS). Floating system is needed for those drugs having a stomach or upper small intestine absorption window. This process does not affect on the rate of gastric emptying over an extended time as it a less dense method and therefore stay buoyant in the stomach and slowly release the drug. System floats on the gastric contents thereby releasing the drug slowly at a desired rate from the system which results in an increased gastric residence time (GRT) and a better control of the fluctuations in

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Mir P, Ahad. "Formulation and Characterization of a New Gastrointestinal Drug Delivery System of Cinnarizine Hydrochloride." International Journal of Pharmacognosy & Chinese Medicine 7, no. 2 (2023): 1–16. http://dx.doi.org/10.23880/ipcm-16000248.

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The goal of this study was to create and test an in vitro floating drug delivery system employing polymers such as sodium carboxymethyl cellulose (CMC Sodium), Xanthan gum (XG), and sodium alginate (SA), using cinnarizine hydrochloride (CNZ) as the model drug. The efficacy of the model drug was proven during the pre-formulation research. 18 distinct formulations were developed using a direct compression (effervescent) technique (F1-F18). As a gas generator, sodium bicarbonate was employed. Physical properties such as weight variation, hardness, friability, floating lag time, and total floating

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Pasa, Gourishyam, Prasanta Kumar Choudhury, and Ghanshyam Panigrahi. "FORMULATION DESIGN AND OPTIMIZATION OF ORAL FLOATING MATRIX TABLETS OF CIPROFLOXACIN HCL BY USING HPMC AND XANTHAN GUM WITH EXPERIMENTAL DESIGN." Asian Journal of Pharmaceutical Research and Development 6, no. 6 (2018): 23–35. http://dx.doi.org/10.22270/ajprd.v6i6.430.

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The oral floating matrix tablets of Ciprofloxacin Hydrochloride were formulated by Experimental design by using HPMC K100M and Xanthan gum as the retardant polymers each with three different levels with an approach to increase gastric residence and thereby improve drug bioavailability. From FTIR results confirm the absence of chemical interaction between the drug with the excipients used in tablet formulations. Also, there was no shift in the endotherm of in the drug- excipients mixtures indicating compatibility of drug with all the excipients. All the tablets were prepared by effervescent app

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Chaturvedi, Prateek Kumar, Rajesh Gour, Janki Prasad Rai, and Akhlesh Kumar Singhai. "Development and Evaluation of Losartan Potassium Floating Matrix Tablet." Journal of Drug Delivery and Therapeutics 12, no. 3-S (2022): 106–14. http://dx.doi.org/10.22270/jddt.v12i3-s.5388.

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The present study was aimed towards the development of controlled release formulations of Losartan Potassium based on designed to enhance the bioavailability by prolonging its duration in the stomach via the floating dosage forms with controlled release. This study was intended to evaluate the influence of formulation variables like levels of polymer, amount of mannitol concentrations, and coating solution ratios of semi permeable membrane on the drug release from the developed formulations. Thus, there is a strong clinical need and market potential for a dosage form that will deliver Losartan

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Kenjale, Prathmesh P., Manjusha A. Joshi, Umesh N. Khatavkar, Vividha V. Dhapte, and Varsha B. Pokharkar. "Paroxetine Hydrochloride Push-pull Osmotic Pump Tablets: Designing an Innovative, Scalable Push-pull Osmotic Drug Delivery System Using QbD Approach." Drug Delivery Letters 10, no. 2 (2020): 104–16. http://dx.doi.org/10.2174/2210303109666190902112941.

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Background: Paroxetine hydrochloride hemihydrate (PHH) is a serotonin reuptake inhibitor useful for the treatment of diverse psychiatric problems. Existing marketed formulations with frequent administration lead to gastrointestinal (GI) reactions and abrupt fluctuations in plasma level with poor patient compliance. These prerequisites are sufficed by controlled release push-pull osmotic pump tablets (PPOP). Objective: Objective of the present study was to develop robust and reliable PPOP formulation via Quality by design (QbD) approach to achieve desired release kinetics. Methods: PPOP was for

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E., Sathish Reddy Meesala. Srinivasa Rao and Mohammed Ibrahim. "FORMULATION AND IN VITRO, IN VIVO EVALUATION OF CEFADROXIL CONTROLLED GASTRORETENTIVE DRUG DELIVERY SYSTEM." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2139–50. https://doi.org/10.5281/zenodo.836461.

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Introduction: Cefadroxil is a first-generation cephalosporin and is very effective against Gram positive and Gram negative infections. Cefadroxil is an antibiotic agent which has high absorption in the upper part of the gastrointestinal tract (GIT). Conventional Cefadroxil tablets produce rapid and relatively high peak blood level and require frequent administration to keep the plasma drug level at an effective range. The present study was carried out with an objective of preparation and in vivo evaluation of floating tablets of using Cefadroxil as a model drug using Eudragit polymers to impro

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Panda, Subhranshu, C. H. Surya Kumari, and G. Puniya. "FORMULATION AND EVALUATION OF COMPRESSION COATING FLOATING TABLETS OF CARVEDILOL PHOSPHATE ONCE DAILY DOSE." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 6 (2018): 82. http://dx.doi.org/10.22159/ijpps.2018v10i6.25367.

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Objective: The rationale for the study was to develop a once-daily dose of immediate as well as a gastro-retentive form of carvedilol phosphate by compression coating floating technique.Methods: In the presented study the core tablet was containing half the quantity of the drug formulated as floating drug delivery using different controlled release polymers blend in various proportions like ethyl cellulose, carbopol, hydroxypropyl methylcellulose (HPMC) K4, K15, and K100 by direct compression method. Outer coat layer was formulated with rest of the drug with the blend of different super disint

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Janardhan, Dumpeti, Sreekanth Joginapally, Bharat V., and Rama Subramaniyan P. "Formulation and Evaluation of Gastro Retentive Drug Delivery System for Ofloxacin." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 1 (2009): 428–34. http://dx.doi.org/10.37285/ijpsn.2009.2.1.6.

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The purpose of this investigation was to prepare a gastroretentive drug delivery system of Ofloxacin. Ofloxacin is a fluoroquinolone antibacterial which acts by inhibiting the topoisomerase enzyme which is essential in the reproduction of the bacterial DNA. It is highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence, a gastroretentive system was developed to enhance the bioavailability by retaining it in the acidic environment of the stomach. Different formulations were formulated using various concentrations of hydroxy propyl methyl cellulose,

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Ittadwar, Parul A., and Prashant k. Puranik. "Formulation and Evaluation of Gastro-retentive Drug Delivery System of Novel Famotidine Phospholipid Complex." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 03 (2023): 250–59. http://dx.doi.org/10.25004/ijpsdr.2023.150304.

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Famotidine is an H2 receptor antagonist belonging to the BCS Class II, characterized by low solubility and limited oral bioavailability. The current study encompasses the formulation of novel famotidine phospholipid complex (FHC) with the aid of design of experiments (Central Composite Design) using solvent evaporation technique to overcome the disadvantages of Famotidine. To further enhance the physicochemical properties of FHC, it was incorporated into gastro-retentive floating tablets (GRDDS) using direct compression technique with sodium bicarbonate as a gas generating agent and its proper

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Rasel, Mohammad Abu Taher, and Moynul Hasan. "Formulation and Evaluation of Floating Alginate Beads of Diclofenac Sodium." Dhaka University Journal of Pharmaceutical Sciences 11, no. 1 (2012): 29–35. http://dx.doi.org/10.3329/dujps.v11i1.12484.

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The objective of this present investigation is to develop gastroretentive sustained release alginate beads of Diclofenac sodium by the ionotropic gelation method. The floating beads were prepared by dispersing Diclofenac sodium together with CaCO3 (as gas forming agent) into a solution of sodium alginate. The resulting solution was then extruded through a 22 gauge syringe needle into 100 ml cross-linking solution containing calcium chloride (1% w/v) plus acetic acid (10% v/v). Prepared beads were evaluated for their encapsulation efficiency, buoyancy test, FT-IR spectroscopy, scanning electron

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Pamu, Sandhya, Subrahmanyam C. V. S, and Patnaik K. S. K. Rao. "Formulation of Gastro-retentive Floating Tablets of Valsartan by 2 power 2 Factorial Designs: In vitro and In vivo Evaluations." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 2 (2019): 4496–505. http://dx.doi.org/10.37285/ijpsn.2019.12.2.7.

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An oral dosage form containing gastro-retentive floating tablets forms a stomach-specific drug delivery system for the treatment of hypertension. Valsartan belongs to the BCS class II (poo Classification System). It is desirable to improve the extent of bioavailability (23%). The objective of the present study was to apply design of experiment to optimize floating drug delivery of valsartan by employing 22 factorial design. Improvement of the aqueous solubility of valsartan was done by solid dispersions using hot melt extrusion technique. Plasdone S630 copovidone is a variable carrier and drug

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