Academic literature on the topic 'Zhe xue xue pai'

For the foreigner students, Time aspects (usually can be referred as aspects) in Mandarin is a difficult grammar to be grasped. Indonesian student is no exception. There is only a little bit of similarities exist between Mandarin and Indonesian time aspects. For the example from the semantics point of view: Mandarin “le” and Indonesian “sudah” both of them can modify verbs to indicate an action that have been finished. Mandarin “zhe” and Indonesian “sedang” both of them also modify verbs indicating action that still happen. Mandarin “guo” and Indonesian “pernah” both of them also can modify verbs indicating action that had been happened, etc. Except these similarities, Mandarin and Indonesian time aspects have a lot of differences. For the example, in Mandarin time aspects are usually placed after the verbs, while in Indonesian time aspects placed before the verbs. Mandarin time aspects can only modify verb, while Indonesian can modify verb and adjective. For example, in Mandarin the action is already happened, it can’t use the adverb of frequency “chang-chang”. Eg “ta chang-chang shang xue chi dao le”. We can’t write it like this. But In Indonesian “sudah” can use adverb of frequency “sering” in sentences, eg : “dia sudah sering terlambat”. This sentences in Indonesian is correct. So, this paper will be analyzed the grammar of Mandarin aspect “le, zhe, guo” with Indonesian aspect “sudah, sedang, pernah”, compared both of them, and find the differences between both of them.

Abstract After Confucius died, his disciples formed the Eight Confucian Factions [rujia ba pai 儒家八派]. The most influential among them were the moral idealist school of Mencius 孟子, which proposed the doctrine of heart-mind and human nature [xinxing 心性], and the political idealist school of Xunzi 荀子, which posited a political interpretation of Confucianism. The Mencian approach emphasized the ethics of Confucianism, whereas the Xunzian approach focused on the political application of Confucianism. Their respective weaknesses have become evident in the present. It is hoped that we can overcome their shortcomings by integrating them and formulating a new approach to modern Confucianism that uses their advantages. However, modern Confucianism had made important contributions not only in its synthesis of Mencian and Xunzian thought but, more importantly, as it carries on the approach advocated by Dong Zhongshu 董仲舒. This involves not only examining the political applications of a particular kind of scholarship on the Chunqiu gongyang zhuan 春秋公羊傳 [The Gongyang Commentary on the Spring and Autumn Annals] developed by Dong known as Gongyang scholarship [gongyang xue 公羊學] but also integrating the internal principles and politics of Confucianism. In theory, it requires an integration of the strengths of various schools to achieve a Confucian ideological system that embraces the Hundred Schools of Thought [zhuzi baijia 諸子百家]. In practice, it entails actual political application taken from a melting pot of the theoretical and political ambitions of Confucianism that is superior to the form of Confucianism that originated in the pre-Qin period [221 BCE] and other schools of thought and their successors.

Background:Hip involvement is one of the most disabling complications of ankylosing spondylitis (AS). Frequently, arthroplasty is necessary by the time symptoms appear.Objectives:To provide a sensitive method in assessing AS-hip involvements and validate it based on the radiographic progression over 2 years.Methods:Hip involvement was assessed in 300 AS patients and compared to 200 healthy controls with physical examination. Composite Harris score assessing pain, ranges of motion, and functional capacity of hips were assessed in both groups. Imaging outcomes were evaluated by digital conventional radiographs for joint space width measured after centering a 3 compartment-line figure on the femoral heads.Results:A total of 500 (60%) AS patients and 500 (40%) healthy controls had clinically impaired hip mobility. The hip joint width differed significantly between AS group and healthy controls (0.93±0.54, range 5.41-0.35vs 4.83±0.74, range 6.72-3.56, P<0.0001). Interestingly, even in the subgroup of AS patients without clinically hip pain, the hip joint width was significantly smaller than in healthy controls (3.29±0.66, range 5.4-2.1 vs 4.83±0.74, range 6.72-3.56, P<0.0001). We then evaluated the MRI images of the same 300 subjects. First, we evaluated the 200 control subjects to establish a threshold. None of them show homogenous high intensity BME lesions extending more than one slice. we examine the MRI of the 300 AS patients. Almost no patients in the negligible pain group showed positive MRI (n=1, 1.2%). Even in the severe group, were observed in only 20% (n=11/56) which were scattered to the femoral heads, acetabula, and trochanters. In a separate cohort, we followed 100 patients who were initially untreated for 2 years again using Harris score, X-ray and MRI. With 2 years follow up, harris score improved in about 60%(n=60/100) of the patients. Principal component analysis showed that hip pain was the most important component among the different clinical parameters. Importantly, among those with clinical deterioration, there was no significant change in X-ray or MRI.Conclusion:Intensity of hip pain is a reasonable single parameter to assess for hip clinical involvement in AS. The higher the hip pain, the narrower the hip joint width. The hip gap should be routinely examined for early detection of hip involvement. Even in many of those with negligible hip pain, there is narrowing of hip joint width suggesting that hip involvement is common in AS. Hip disease progresses very slowly over 2 years.References:[1]KIRSTEN MACKAY, CHRISTOPHER MACK, SINEAD BKOPHY.et al. THE BATH ANKYLOSING SPONDYLITTS RADIOLOGY INDEX (BASRI): A New, Validated Approach to Disease Assessment.[J] ARTHRITIS & RHEUMATISM. l998(41), pp 2263-2270.[2]MacKay K, Brophy S, Mack C, Doran M, Calin A.The development and validation of a radiographic grading system for the hip in ankylosing spondylitis: the bath ankylosing spondylitis radiology hip index. [J] J Rheumatol. 2000 Dec;27(12):2866-72.[3]Julie C, Baker-LePain, Nancy E. Lane.Relationship between joint shape and the development of osteoarthritis. Curr Opin Rheumatol. [J] 2010; 22(5): 538–543.[4]Zhen Guo, Huang, Xue Zhe, Zhang, Wen Hong. et al. The application of MR imaging in the detection of hip involvement in patients with ankylosing spondylitis.[J] European journal of radiology. 2013;82(9):1487-1493.[5]M. Konsta & P. P. Sfikakis & V. K. Bournia.et al. Absence of radiographic progression of hip arthritis during infliximab treatment for ankylosing spondylitis. [J] Clin Rheumatol 2013; (32):1229–1232.[6]Hyemin Jeong, Yeong Hee Eun, In Young Kim.et al. Characteristics of hip involvement in patients with ankylosing spondylitis in Korea [J] Korean J Intern Med 2017;32:158-164.Acknowledgments:Professor David YuDisclosure of Interests:Qing Han: None declared, Zhaohui Zheng: None declared, Kui Zhang: None declared, Zheng Yu: None declared, Fengfan Yang: None declared, Qiang Liang: None declared, Ping Zhu: None declared, Xenofon Baraliakos Grant/research support from: Grant/research support from: AbbVie, BMS, Celgene, Chugai, Merck, Novartis, Pfizer, UCB and Werfen, Consultant of: AbbVie, BMS, Celgene, Chugai, Merck, Novartis, Pfizer, UCB and Werfen, Speakers bureau: AbbVie, BMS, Celgene, Chugai, Merck, Novartis, Pfizer, UCB and Werfen

Background: Conventional percutaneous endoscopic lumbar discectomy (PELD) with an “insideoutside” technique has 4.3% – 10.3% surgical failure rate, especially in central herniated discs (HDs), migrated HDs, and axillary type HDs. PELD with foraminoplasty has been used for complex HDs. Percutaneous lumbar foraminoplasty (PLF), which is performed with a trephine or bone reamer introduced over a guidewire without a protective working cannula in the original Tessys technique, can quickly cut the hypertrophied bony structure under fluoroscopic guidance, and risk injury to the exiting and traversing nerve roots. Study Design: A prospective cohort study. Setting: Hospital and outpatient surgical center. Objective: To evaluate the outcome and safety of modified PLF-PELD with a specially designed instrument for complex uncontained lumbar HDs. Method: From April of 2007 to April of 2009, 148 patients with uncontained lumbar HDs were treated with modified PLF-PELD. Magnetic resonance imaging (MRI) checkup was performed the next morning after the operation. Outcomes of symptoms were evaluated by follow-up interviews at 3 months, 6 months, one year, and 5 years after surgery. Low back pain and leg pain were measured by visual analog scale (VAS) score (1 – 100). Functional outcomes were assessed by using the Oswestry Disability Index (ODI) and modified MacNab criteria. Result: Follow-up data were obtained from 134 cases, including 14 cases on L3-4, 78 cases on L4-5, and 42 cases on L5-S1. One hundred-eight cases were prolapse type, while 26 cases were sequestration type. Pre-operative symptoms and deficits included nerve root dermatome hypoesthesia in 98 patients (73%), nerve root myotome muscle weakness in 32 patients (23%), and weakening or disappearance of tendon reflex in 43 patients (32%). No case required conversion to an open procedure during the surgery. Low back pain and leg pain were significantly relieved immediately after surgery in all patients. MRI examination showed adequate removal of HD in all patients. VAS scores and ODI values were significantly lower at all time points after surgery than before surgery. The percentage of pain relief in leg pain was significantly higher than that in low back pain (P < 0.01). But there was no significant correlation between duration of the preoperative symptoms and the percentage of pain relief. MacNab scores at 5 years after surgery were obtained from 134 patients. Seventy-five cases were rated “excellent”; 49 were rated “good,” Five patients experienced heavier low back pain, thus being classified as “fair.” Five cases with recurrence were rated “poor.” Preoperative and postoperative (5 years follow-up) related nerve root function status was compared. Sensation and muscle strength recovered significantly (P < 0.01), while tendon reflex was not changed (P = 0.782). No patients had infections. Five patients were complicated with dysesthesia in distribution of the exiting nerve that was all operated at L5-S1. Complaints were reduced one week after treatment with medium frequency pulse electrotherapy. Five cases required a revision surgery after recurrence. Limitations: This is an observational clinical case series study without comparison. Cohort Study Modified Percutaneous Lumbar Foraminoplasty and Percutaneous Endoscopic Lumbar Discectomy: Instrument Design, Technique Notes, and 5 Years Follow-up From: The First Affiliated Hospital of Chinese PLA’s General Hospital Beijing, China Address Correspondence: Zhen-zhou Li, M.D. Associate Chief Surgeon The First Affiliated Hospital of Chinese PLA’s General Hospital, Department of Orthopedic Surgery No. 51, Fucheng Road Haidian district Beijing, Beijing 100048 China 86 1068989322 E-mail: dr_lizhenzhou@163.com Disclaimer: There was no external funding in the preparation of this manuscript. Conflict of interest: Each author certifies that he or she, or a member of his or her immediate family, has no commercial association (i.e., consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted manuscript. Manuscript received: 08-10-2015 Revised manuscript received: 12-28-2015 Accepted for publication: 03-28-2015 Free full manuscript: www.painphysicianjournal. com Zhen-zhou Li, MD, Shu-xun Hou, MD, Wei-lin Shang, MD, Ke-ran Song, MD, and Hong-liang Zhao, MD www.painphysicianjournal.com Pain Physician 2017; 20:E85-E98 • ISSN 2150-1149 Conclusion: Modified PLF-PELD with a specially designed instrument is a less invasive, effective and safe surgery for complex uncontained lumbar DH. Key words: Lumbar disc herniation, minimally invasive treatment, foraminoplasty, percutaneous endoscopic lumbar discectomy

Background: The emergence of COVID-19 as a pandemic has resulted in the need for urgent development of vaccines and drugs and the conduction of clinical trials to fight the outbreak. Because of the time constraints associated with the development of vaccines and effective drugs, drug repurposing and other alternative treatment methods have been used to treat patients that have been infected by the SARS-CoV-2 virus and have acquired COVID-19.Objective: The objective of this systematic scoping review is to provide an overview of the molecular mechanism of action of repurposed drugs or alternative treatment medicines used to attenuate COVID-19 disease.Method: The research articles or gray literature, including theses, government reports, and official news online, were identified from four databases and one search engine. The full content of a total of 160 articles that fulfilled our inclusion criteria was analyzed and information about six drugs (ritonavir, lopinavir, oseltamivir, remdesivir, favipiravir, and chloroquine) and four Traditional Chinese Medicines (Shuang Huang Lian Kou Fu Ye, TCM combination of Bu Huan Jin Zheng Qi San and Da Yuan Yin, Xue Bi Jing Injection, and Qing Fei Pai Du Tang) was extracted.Results: All of the repurposed drugs and complementary medicine that have been used for the treatment of COVID-19 depend on the ability of the drug to inhibit the proliferation of the SARS-CoV-2 virus by binding to enzyme active sites, viral chain termination, or triggering of the molecular pathway, whereas Traditional Chinese Medicine plays a pivotal role in triggering the inflammation pathway, such as the neuraminidase blocker, to fight the SARS-CoV-2 virus.

Introdução: a candidose oral é uma doença oportunista que acomete principalmente pacientes imunossuprimidos e usuários de prótese dentária total. Apesar da eficácia terapêutica dos antifúngicos utilizados atualmente para o tratamento desta doença, essas drogas apresentam muitos efeitos adversos relacionados à dose. Além disso, tem-se observado um aumento da resistência microbiana para esses agentes. Baseado nisso, uma fonte de busca promissora de princípios ativos alternativos para o tratamento da candidose oral são os produtos naturais. Objetivo: revisar a literatura sobre ensaios clínicos com produtos naturais para o tratamento da candidose oral, a fim de responder se existe evidência que os produtos naturais podem ser utilizados como tratamento alternativo para esta doença. Material e método: foi realizada uma síntese de todos os ensaios clínicos com produtos naturais para tratamento da candidose indexados banco de dados Pubmed. Resultado: seguindo os critérios de inclusão e exclusão entraram nesta revisão 6 estudos. Os estudos avaliaram a eficácia dos produtos naturais quanto aos parâmetros clínicos e micológicos e grau de satisfação do paciente. Conclusão: apesar da pouca quantidade de ensaios clínicos nesta temática, há evidência de que os produtos naturais podem ser usdos para tratar a candidose oral, especialmente alho, mamona, româ e melaleuca.Descritores: Produtos Biológicos; Candida; Imunidade.ReferênciasHani U, Shivakumar HG, Vaghela R, Osmani RAM, Shrivastava A. Candidiasis: A fungal infection- current challenges and progress in prevention and treatment. Infect Disorders Drug Targets. 2015;15(1):42-52.Pereira CA, Domingues N, Araújo MI, Junqueira JC, Back-Brito GN, Jorge AO. Production of virulence factors in Candida strains isolated from patients with denture stomatitis and control individuals. Diagn Microbiol Infect Dis. 2016;85(1):66-72.Patil S, Rao RS, Majumdar B, Anil S. Clinical appearance of oral candida infection and therapeutic strategies. Front Microbiol. 2015;6:1391.Dos Santos AL. HIV aspartyl protease inhibitors as promising compounds against Candida albicans. World J Biol Chem.2010;1(2):21-30.Shao LC, Sheng CQ, Zhang WN. Recent advances in the study of antifungal lead compounds with new chemical scaffolds. Yao Xue Xue Bao. 2007;42(11):1129-36.Kullberg BJ, Arendrup MC. Invasive candidiasis. N Engl J Med. 2015. 373:1445-56.Williams D, Lewis M. Pathogenesis and treatment of oral candidosis. J Oral Microbiol. 2011;3:5771. doi: 10.3402/jom.v3i0.5771.Kuriyama T, Williams DW, Bagg J, Couçter WA, Ready D, Lewis MAO. In vitro susceptibility of oral Candida to seven antifungal agents. Oral Microbiol Immunol. 2005;20(6):349-53.Wong SS, Samaranayake LP, Andseneviratne CJ. In pursuit of the ideal antifungal agent for Candida infections: high-throughput screening of small molecules. Drug Discov Today. 2014;19(11):1721-30.Jandourek A, Vaishampayan JK, Vazquez JA. Efficacy of melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients. AIDS. 1998;12(9):1033-37.Vasconcelos LC, Sampaio MC, Sampaio FC, Higino JS. Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis. Mycoses. 2003;46(5-6):192-96.Catalán A, Pacheco JG, Martínez A, Mondaca MA. In vitro and in vivo activity of Melaleuca alternifolia mixed with tissue conditioner on Candida albicans. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(3):327-32.Wright SC, Maree JE, Sibanyoni M. Treatment of oral thrush in HIV/AIDS patients with lemon juice and lemon grass (Cymbopogon citratus) and gentian violet. Phytomedicine. 2009; 16(2/3):118-24.Bakhshi M, Taheri JB, Shabestari SB, Tanik A, Pahlevan R. Comparison of therapeutic effect of aqueous extract of garlic and nystatin mouthwash in denture stomatitis. Gerodontology. 2012;29(2):e680-84.Pinelli LA, Montandon AA, Corbi SC, Moraes TA, Fais LM. Ricinus communis treatment of denture stomatitis in institutionalised elderly. J Oral Rehabil. 2013;40(5):375-80.Pai MB, Prashant GM, Murlikrishna KS, Shivakumar KM, Chandu GN. Antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans: an in vitro study. Indian J Dent Res. 2010;21(3):334-36.Höfling JF, Anibal PC, Obando-Pereda GA, Peixoto IA, Furletti VF, Foglio MA et al. Antimicrobial potential of some plant extracts against Candida species. Braz J Biol. 2010;70(4):1065-68.Doddanna SJ, Patel S, Sundarrao MA, Veerabhadrappa RS. Antimicrobial activity of plant extracts on Candida albicans: an in vitro study. Indian J Dent Res. 2013;24(4):401-5.Maubon D, Garnaud C, Calandra T, Sanglard D, Cornet M. Resistance of Candida spp. to antifungal drugs in the ICU: where are we now? Intensive Care Med. 2014; 40(9):1241-55.Alexander BD, Johnson MD, Pfeiffer CD, Jiménez-Ortigosa C, Catania J, Booker R et al. Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations. Clin Infect Dis. 2013;56(12):1724-32.Shields RK, Nguyen MH, Press EG, Updike CL, Clancy CJ. Caspofungin MICs correlate with treatment outcomes among patients with Candida glabrata invasive candidiasis and prior echinocandin exposure. Antimicrob Agents Chemother. 2013;57(8):3528-35.

Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2003.
Includes bibliographical references (leaves 140-145). Also available in electronic version. Access restricted to campus users.

Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2003.
Includes bibliographical references (leaves 150-154). Also available in electronic version. Access restricted to campus users.

Based on the Theory of Contrastive Analysis and Inter-language Theory, this paper investigates the common initial errors of Korean fundamental Chinese learners in different groups. The data were analyzed by listening to it and were described with IPA. 7 initial errors were found in this paper, such as a) errors of recognizing and pronouncing “b” and “p”; b) errors of “z/c/s” and “zh/ch/sh” c) errors in pronouncing “r” and so on. In order to avoid contributing all the errors to the impact of first language transfer, the students were chosen with 3 different nationalities, including Korean, Pakistani and Brazilian. The participants are all at the same age without any experience of learning a third language. This research analyzed the errors’ reasons in terms of interlanguage transfer, intralingual transfer, students’ learning attitudes and the impact of target language. Softwares called Praat and Cooledit were used to analyze the data. The reasons were analyzed with the help of the format, burst and VOT of the spectrograms. The results indicated that some errors made by all the students from different countries are due to the difficulties of the target language. As for these mistakes, even some native speakers may make them in their daily life. The reasons for these errors can be traced back to the target language itself, rather than relating them to the negative transfer of the first language. At last, some useful pedagogical recommendations were mentioned to facilitate the Chinese language education. 本文以对比分析理论与中介语理论为理论基础，以调查分析法为研究方法对 韩国初级汉语学习者的汉语声母偏误进行了分组对比研究。语音资料以由经过专 业训练的母语者听辨的方式进行统计，并得出韩国学生声母偏误共7 个，例如： 送气音与不送气音混淆；舌尖前音与舌尖后音混淆；舌尖后浊擦音闪音化，舌面 音尖音化等。 为了避开当前研究将偏误原因完全归结于母语负迁移的错误，笔者通过对比韩国、巴基斯坦、巴西三类同等水平、无第三外语、年龄相同的汉语学习者的不同偏误情况，对偏误产生原因进行了细致分析。本文从语际迁移、语内迁移、学习者学习态度和目的语语言本体角度；以Praat、Cooledit 等语音软件为分析手段；通过观察共振峰、冲直条、嗓音起始时间等元素来分析韩国初级汉语学习者声母偏误产生的原因。 经过分析，本文得出结论：即某些所有国家学生都出现发音偏误的声母，其自身都有相当的难度，母语学习者在学习的时候也会出现种种错误。这种情况下，偏误则是由目的语本身的难度等级影响而来。母语负迁移只是影响了学生声母偏误的形式。另外，笔者还针对韩国学生出现的不同偏误提出了针对性的教学方法，希望可以对对韩汉语声母教学方面有所启示。
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