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1

Bhaskar, Elvin, and Chung H. Kau. "A Comparison of 3D Facial Features in a Population from Zimbabwe and United States." European Journal of Dentistry 14, no. 01 (February 2020): 100–106. http://dx.doi.org/10.1055/s-0040-1702258.

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Abstract Objectives The purpose of this study was to determine the differences in three-dimensional (3D) facial features in a population from Zimbabwe and the United States. In addition, this study seeks to establish an average facial template of each population allowing clinicians to treat patients according to their cultural esthetic perceptions. Materials and Methods Three hundred one subjects from Zimbabwe and the United States were carefully selected and recruited for the study. Each subject presented with a normal facial profile, no asymmetries, and normal body mass index. The 3D images were captured using the 3dMD cameras. All images were further separated into male and female groups of the respective populations and imported to a dedicated software for analysis. Statistical Analysis The 3D facial images were constructed using Rapidform 6 software to recreate a composite facial average for each group representing a male and female average 3D face of Zimbabwean (Zim) and United States origin. Results The linear measurements showed that the maximum average distance between the Zim-M and Zim-F was 1.24 mm and the minimum distance between the African American (AA)-M and AA-F was 0.24 mm. This was the absolute distance. When the signed linear measurements were taken into consideration, the maximum average distance between Zim-F and AA-M was 1.22 mm and the least average distance between the Zim-M and AA-M was 0.22 mm. The absolute color histograms showed greatest similarity between the Zim-M and AA-M at 58% and the Zim-F had a 25 and 27% similarity with the AA-F and Zim-M, respectively. Conclusion The Zim-F showed the most variable features with a broader face, prominent forehead, and retruded alar base compared with their male counterparts and the Zim-M showed a wider prominent malar/zygomatic region, and prominent lateral supraorbital regions. There was a high similarity of 58% between the Zim-M and the AA-M, with the Zim-M showing a more protrusive superciliary arches, and a lateral zygomatic region tapering to the root of the nose.
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2

Bunke, Hendrik, Sandra Ostermann, and Elin-Birgit Berndt. "Freies ZIMmer. Technologie- und Lernkulturen im "Zentrum für Interaktion mit Digitalen Medien" (ZIM)." Medien in der Erziehungswissenschaft II 10, Medien in der Erz.-wiss. II (June 23, 2005): 1–9. http://dx.doi.org/10.21240/mpaed/10/2005.06.23.x.

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Das ZIM an der Universität Bremen ist eine Lern- und Forschungswerkstatt für Digitale Medien in der Bildung. Der Beitrag erläutert Idee und Konzept des ZIM, schildert die Kooperation mit einer Schule im Projekt «ZIM@School» und skizziert als kurzen Ausblick methodische und inhaltliche Fragen der Evaluierung.
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Liu, Yahong, Xiaojing Guo, Shuai Gu, and Xiaopeng Zhao. "Zero Index Metamaterial for Designing High-Gain Patch Antenna." International Journal of Antennas and Propagation 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/215681.

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A planar wideband zero-index metamaterial (ZIM) based on mesh grid structure is studied. It is demonstrated that the real part of the index approaches zero at the wideband covering from 9.9 GHz to 11.4 GHz. Two conventional patch antennas whose operating frequencies are both in the range of zero-index frequencies are designed and fabricated. And then, the ZIM is placed in the presence of the conventional patch antennas to form the proposed antennas. The distance between the antenna and the ZIM cover is investigated. Antenna performances are studied with simulations and measurements. The results show that the more directional and higher gain patch antennas can be obtained. The measured results are in good agreement with the simulations. Compared to the conventional patch antenna without the ZIM, it is shown that the beamwidth of antenna with the ZIM cover becomes more convergent and the gain is much higher.
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4

Ahmadlou, Mehran, Janou H. W. Houba, Jacqueline F. M. van Vierbergen, Maria Giannouli, Geoffrey-Alexander Gimenez, Christiaan van Weeghel, Maryam Darbanfouladi, et al. "A cell type–specific cortico-subcortical brain circuit for investigatory and novelty-seeking behavior." Science 372, no. 6543 (May 13, 2021): eabe9681. http://dx.doi.org/10.1126/science.abe9681.

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Exploring the physical and social environment is essential for understanding the surrounding world. We do not know how novelty-seeking motivation initiates the complex sequence of actions that make up investigatory behavior. We found in mice that inhibitory neurons in the medial zona incerta (ZIm), a subthalamic brain region, are essential for the decision to investigate an object or a conspecific. These neurons receive excitatory input from the prelimbic cortex to signal the initiation of exploration. This signal is modulated in the ZIm by the level of investigatory motivation. Increased activity in the ZIm instigates deep investigative action by inhibiting the periaqueductal gray region. A subpopulation of inhibitory ZIm neurons expressing tachykinin 1 (TAC1) modulates the investigatory behavior.
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5

Grau, Christoph. "1. ZIM-Workshop: Individualisierung in der Medienbranche durch neue Technologien." MedienWirtschaft 3, no. 2 (2006): 70–71. http://dx.doi.org/10.15358/1613-0669-2006-2-70.

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Im April 2005 wurde das interdisziplinäre Zentrum für Internetforschung und Medienintegration (ZIM) an der Ludwig-Maximilians-Universität München ins Leben gerufen. Das ZIM ist eine Gemeinschaftsinitiative von Instituten und Lehrstühlen der Betriebswirtschaftslehre, der Kommunikationswissenschaft und der Informatik mit dem Ziel, interdisziplinäre Forschungsprojekte zur Transformation der Medien- und Telekommunikationsindustrie durch digitale Medien zu fördern.
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6

Huang, Yunqing, and Jichun Li. "Total Reflection and Cloaking by Triangular Defects Embedded in Zero Index Metamaterials." Advances in Applied Mathematics and Mechanics 7, no. 2 (March 23, 2015): 135–44. http://dx.doi.org/10.4208/aamm.2014.m659.

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AbstractIn this work, we investigate wave propagation through a zero index meta-material (ZIM) waveguide embedded with triangular dielectric defects. We provide a theoretical guidance on how to achieve total reflection and total transmission (i.e., cloaking) by adjusting the defect sizes and/or permittivities of the defects. Our work provides a systematical way in manipulating wave propagation through ZIM in addition to the widely studied dielectric defects with cylindrical and rectangular geometries.
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7

Rahmad, Cahya, Rahmat Satrio Wibowo, and Dwi Puspitasari. "Peramalan Penjualan Daging Sapi Menggunakan Metode Trend Least Square." Jurnal Teknologi Informasi dan Terapan 6, no. 1 (August 31, 2019): 7–11. http://dx.doi.org/10.25047/jtit.v6i1.104.

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Toko dan supplier daging sapi Hari®Zim adalah toko yang menjual berbagai jenis daging sapi seperti jenis daging serloin, tenderloin, lidah, gandik, paru, buntut potong, iga potong, otak, kaki A (kaki matang), kaki b (kaki lepas tulang), kaki c (kaki kerok bulu), kulit, jantung, frozzen AMH, frozzen LVRN, tahu campur, dan rawonan. Toko ini berdiri pada tahun 2012. Namun, selama ini target penjualan untuk masa depan tidak obyektif karena masih berbasis pada manajemen intuitif dan masih dipengaruhi oleh pendapat atau perasaan pembuatnya. Oleh karena itu dibutuhkan sebuah sistem yang dapat membantu manajemen untuk menentukan target penjualan di masa depan secara lebih obyektif, sehingga penentuan target penjualan bisa lebih akuntabel. Selama ini toko daging sapi Hari®Zim dalam pengelolahan stok daging tidak dinamis atau tidak disesuaikan dengan perkiraan penjualan berikutnya karena belum menggunakan sistem prediksi. Oleh karena itu perlu adanya suatu sistem yang dapat memprediksi penjualan daging tersebut. Dalam penelitian ini, permasalahan yang akan dibahas adalah menguji apakah model peramalan time series dengan menggunakan metode Trend Least Square yang akan digunakan sudah sesuai dengan kondisi perusahaan, sehingga Toko daging sapi Hari®Zim tetap eksis dalam menghadapi persaingan usaha yang sejenis. Penelitian ini dilakukan dengan menggunakan data primer berupa data penjualan daging sapi periode Januari 2015 – Mei 2017 pada toko daging sapi Hari®Zim Malang. Pengujian sistem dilakukan tiga kali, masing-masing uji komposisi menggunakan jumlah data pelatihan yang berbeda. Kemudian akan dibandingkan dengan data penjualan aktual untuk mengetahui hasil peramalan terbaik dan mendapatkan nilai kesalahan peramalan terkecil dengan Mean Absolute Presentase Error (MAPE). Kesalahan perkiraan terbaik ditemukan pada tes ketiga dengan menggunakan data pelatihan 9 bulan dan di dapatkan hasil perhitungan MAPE sebesar 0,022251 (2%). Berdasarkan hasil pengujian sistem menunjukkan bahwa jumlah data yang digunakan mempengaruhi Mean Absolute Presentase Error (MAPE). Aplikasi yang dikembangkan dapat di rekomendasikan untuk menentukan jumlah stok bulan berikutnya pada Toko daging sapi Hari®Zim.
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8

Aguiar, Marian. "N�zim Hikmet's Modernism of Development." Journal of Modern Literature 30, no. 4 (June 2007): 105–21. http://dx.doi.org/10.2979/jml.2007.30.4.105.

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9

Peng, Yu, and Shaolin Liao. "ZIM Laser: Zero-Index-Materials Laser." IEEE Journal on Multiscale and Multiphysics Computational Techniques 4 (2019): 133–42. http://dx.doi.org/10.1109/jmmct.2019.2905368.

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10

Silkin, Vyacheslav M., Eugene Kogan, and Godfrey Gumbs. "Screening in Graphene: Response to External Static Electric Field and an Image-Potential Problem." Nanomaterials 11, no. 6 (June 13, 2021): 1561. http://dx.doi.org/10.3390/nano11061561.

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We present a detailed first-principles investigation of the response of a free-standing graphene sheet to an external perpendicular static electric field E. The charge density distribution in the vicinity of the graphene monolayer that is caused by E was determined using the pseudopotential density-functional theory approach. Different geometries were considered. The centroid of this extra density induced by an external electric field was determined as zim = 1.048 Å at vanishing E, and its dependence on E has been obtained. The thus determined zim was employed to construct the hybrid one-electron potential which generates a new set of energies for the image-potential states.
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11

Zvavahera, Promise, and Farai Chigora. "Food and Nutrition Promotion: Feasibility of the Zimbabwe Agenda for Sustainable Socio-Economic Transformation." Business and Management Horizons 3, no. 1 (June 11, 2015): 58. http://dx.doi.org/10.5296/bmh.v3i1.7800.

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Zimbabwe has faced persistent droughts from around year 1990 to date posing a structural food security challenge to the populace. Recently, the government of Zimbabwe introduced a blue print to spearhead and map sustainable balance in tapping value from the available natural and man-made resources in the country. This is known as the Zimbabwe Agenda for Sustainable Socio-economic Transformation Programme (Zim Asset). Amongst its prospects, agriculture and nutrition has been reckoned as a sustainable cluster for economic development. This study was undertaken one and half years after the implementation of Zim Asset as an evaluation mechanism on the successes and challenges faced in transforming the Zimbabwean economy with specific reference to the Food and Nutrition Cluster. The study employed both post positivism and interpretivism philosophies applying quantitative and qualitative approaches in gathering research data. The research instruments included documentary evidence, face to face in-depth interviews and focus groups. The in-depth interviews explored issues to do with resources allocation in line with the Zim Asset agriculture sustenance objectives. Focus was therefore, on the four Ministries supporting the Food and Nutrition Cluster. Eighty percent of the respondents reported that the economic blue print has not made any significant strides in improving the country’s agricultural performance and food security since the inception of Zim Asset in October 2013. It was noted that the country continued to import maize from Zambia and other countries in the region. The major reason for its lack of success was due to the unavailability of resources to support the programme and the fact that land was allocated to unproductive and cell phone farmers. There was consensus that land audit and recapitalisation of the agriculture sector were critical in achieving the desired outcomes. The study recommends that the programme be adequately funded, so that the country can become self-sufficient.
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12

Xi, Rui, Long Li, Yan Shi, Cheng Zhu, and Xi Chen. "High-selective band-reject FSS with dual-band near-zero refractive index based on complementary dual-layer symmetry resonator-ring." International Journal of Microwave and Wireless Technologies 10, no. 2 (December 6, 2017): 243–51. http://dx.doi.org/10.1017/s1759078717000526.

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A new band-reject frequency-selective surface (FSS) based on dual-band near-zero refractive index metamaterial (ZIM) design is presented in this paper. Consisting of a planar array of complementary dual-layer symmetry resonant ring, the proposed FSS exhibits a high-selective band-reject filtering response. From the viewpoint of effective medium, the subwavelength FSS is characterized by near-zero effective magnetic permeability and near-zero effective electric permittivity in two different operational bands, respectively. The corresponding resonant behavior and E-field distributions are analyzed in detail. A prototype of the proposed FSS working in X-band is fabricated and measured. The simulation and experiment results verify the effectiveness and correctness of the ZIM-based design method.
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13

Grau, Christoph. "2. ZIM-Jahrestagung zu „User Generated Content“." MedienWirtschaft 4, no. 2 (2007): 46–47. http://dx.doi.org/10.15358/1613-0669-2007-2-46.

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Anfang Mai 2007 lud das interdisziplinäre Zentrum für Internetforschung und Medienintegration (ZIM) der Ludwig-Maximilians-Universität München (LMU) wieder zu seiner Jahrestagung ein, um der Fachöffentlichkeit ausgewählte Forschungsergebnisse vorzustellen. Dieses Mal stand die Veranstaltung ganz im Zeichen von User Generated Content (UGC). Grundsätzlich sind darunter Inhalte zu verstehen, die von Nutzern ohne direkte Gewinnerzielungsabsicht erstellt werden und für die Distribution über Massenmedien vorgesehen sind (Stöckl/Grau/Hess 2006). Nutzergenerierte Inhalte sind ein aktuelles und scheinbar auch durchaus relevantes Phänomen, was sich nicht zuletzt daran zeigt, dass mit „MySpace“, „YouTube“ und „Wikipedia“ die drei bekanntesten Angebote mit User Generated Content mittlerweile in die Top 20 der weltweit am meisten genutzten Websites vorgestoßen sind. Obwohl sich UGC zunehmendem wissenschaftlichen und praktischen Interesse erfreut, sind viele Fragen in diesem Themenfeld bislang noch ungeklärt. Auf der 2. ZIM-Jahrestagung sollten diese Fragen diskutiert und erste Antworten entwickelt werden.
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14

Curel, Agnès. "« Zim ! Boum ! Et en avant la musique ! »." Ligeia N° 141-144, no. 2 (2015): 57. http://dx.doi.org/10.3917/lige.141.0057.

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15

VANHOLME, B., W. GRUNEWALD, A. BATEMAN, T. KOHCHI, and G. GHEYSEN. "The tify family previously known as ZIM." Trends in Plant Science 12, no. 6 (June 2007): 239–44. http://dx.doi.org/10.1016/j.tplants.2007.04.004.

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16

Hüls, Norbert. "ZIM-Förderung ist der Turbolader für Umwelttechnologien." WASSERWIRTSCHAFT 101, no. 12 (December 2011): 44–45. http://dx.doi.org/10.1365/s35147-011-0183-8.

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17

Camus, M. Florencia, Michael O'Leary, Max Reuter, and Nick Lane. "Impact of mitonuclear interactions on life-history responses to diet." Philosophical Transactions of the Royal Society B: Biological Sciences 375, no. 1790 (December 2, 2019): 20190416. http://dx.doi.org/10.1098/rstb.2019.0416.

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Mitochondria are central to both energy metabolism and biosynthesis. Mitochondrial function could therefore influence resource allocation. Critically, mitochondrial function depends on interactions between proteins encoded by the mitochondrial and nuclear genomes. Severe incompatibilities between these genomes can have pervasive effects on both fitness and longevity. How milder deficits in mitochondrial function affect life-history trade-offs is less well understood. Here, we analyse how mitonuclear interactions affect the trade-off between fecundity and longevity in Drosophila melanogaster . We consider a panel of 10 different mitochondrial DNA haplotypes against two contrasting nuclear backgrounds ( w 1118 (WE) and Zim53 (ZIM)) in response to high-protein versus standard diet. We report strikingly different responses between the two nuclear backgrounds. WE females have higher fecundity and decreased longevity on high protein. ZIM females have much greater fecundity and shorter lifespan than WE flies on standard diet. High protein doubled their fecundity with no effect on longevity. Mitochondrial haplotype reflected nuclear life-history trade-offs, with a negative correlation between longevity and fecundity in WE flies and no correlation in ZIM flies. Mitonuclear interactions had substantial effects but did not reflect genetic distance between mitochondrial haplotypes. We conclude that mitonuclear interactions can have significant impact on life-history trade-offs, but their effects are not predictable by relatedness. This article is part of the theme issue ‘Linking the mitochondrial genotype to phenotype: a complex endeavour’.
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18

Karim Azizi, Mohamed, Taieb Elbellili, Henri Baudrand, and Hichem Trabelsi. "Transmission line approach of zero-index metamaterials and applications using a wave concept iterative method." International Journal of Microwave and Wireless Technologies 11, no. 3 (February 7, 2019): 244–54. http://dx.doi.org/10.1017/s175907871800168x.

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AbstractIn this paper, we propose a novel study of zero-index materials (ZIM) based on lumped element circuits using a wave concept iterative method (WCIP). This method is well used to demonstrate the behavior of zero-index-based microwave applications. This type of metamaterial can maintain the amplitude and the phase of an electromagnetic wave to be constant through the ZIM region, which is an important property to design an in-phase power divider-combiner, enhance the directivity of an embedded source, channel electromagnetic waves without reflection at the interface between waveguides with different cross-sections, and control the transmission of electromagnetic wave by the adjustment of the permittivity of a dielectric defect coated by zero-index metamaterial. The numerical simulations using the WCIP method match the literature and commercial software simulator results.
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Dandira, Martin. "Finding, training, and keeping best service workers." Emerald Emerging Markets Case Studies 2, no. 4 (October 19, 2012): 1–3. http://dx.doi.org/10.1108/20450621211256256.

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Subject area Organisational behaviour, business reengineering and management of change, human resources management. Study level/applicability This case study is intended for undergraduate and post-graduate management degrees. It includes courses on organizational behaviour, human resources management, marketing, business management, travel and tourism and strategic management. Case overview Zim-Zum Welcome Hotel is a hotel in Zimbabwe in the travel and tourism sector. It was facing high turnover of employees and this was affecting the business through continuous hiring and training. The organization decided to introduce changes completely changing the way it does things, focusing on satisfying employees as well as customers. The new approach yielded favourable results, labour turnover dropped significantly and business improved greatly. In an effort to improve service, and increase profit, Zim-Zum has begun radically changing the way it hires, trains and deploys frontline workers. Management also examined how waiters and waitress do their job and concluded that there was supposed to be a division of labour between them and culinary staff. Management of Zim-Zum believe that companies that excel at managing frontline workers understand that excellent service is more than just a transaction. Expected learning outcomes Students can focus on: the importance of redesigning work so that superior service satisfies both the employee and the customer; human resources management is an important factor in improving employee performance and business performance; the importance of external and internal customers in improving company performance.
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Čadež, Neža, Dénes Dlauchy, Peter Raspor, and Gábor Péter. "Ogataea kolombanensis sp. nov., Ogataea histrianica sp. nov. and Ogataea deakii sp. nov., three novel yeast species from plant sources." International Journal of Systematic and Evolutionary Microbiology 63, Pt_8 (August 1, 2013): 3115–23. http://dx.doi.org/10.1099/ijs.0.052589-0.

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Nine methanol-assimilating yeast strains isolated from olive oil sediments in Slovenia, extra virgin olive oil from Italy and rotten wood collected in Hungary were found to form three genetically separated groups, distinct from the currently recognized yeast species. Sequence analysis from genes of the small subunit (SSU) rRNA, internal transcribed spacer region/5.8S rRNA, large subunit (LSU) rRNA D1/D2 domains and translational elongation factor-1α (EF-1α) revealed that the three closely related groups represent three different undescribed yeast species. Sequence analysis of the LSU rRNA gene D1/D2 domains placed the novel species in the Ogataea clade. The three novel species are designated as Ogataea kolombanensis sp. nov. (type strain: ZIM 2322T = CBS 12778T = NRRL Y-63657T), Ogataea histrianica sp. nov. (type strain: ZIM 2463T = CBS 12779T = NRRL Y-63658T) and Ogataea deakii sp. nov. (type strain: NCAIM Y.01896T = CBS 12735T = NRRL Y-63656T).
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21

Chitsike, Colleta. "NGOs, gender, culture and multiculturalism a Zim babwean view." Gender & Development 3, no. 1 (February 1995): 19–24. http://dx.doi.org/10.1080/741921759.

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22

Hillier, S. L., S. L. Achilles, M. N. Austin, H. A. Avolia, L. K. Rabe, L. A. Meyn, F. Mhlanga, and Z. M. Chirenje. "Zim CHIC: impact of contraceptive initiation on vaginal microbiota." American Journal of Obstetrics and Gynecology 217, no. 6 (December 2017): 717–18. http://dx.doi.org/10.1016/j.ajog.2017.08.091.

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23

Cole, DL, and N. Mapuranga. "Reaction of Indicator Tobacco Cultivars to Races of Pseudomonas syringaepv. tabaciTox+." Beiträge zur Tabakforschung International/Contributions to Tobacco Research 19, no. 7 (October 1, 2001): 353–59. http://dx.doi.org/10.2478/cttr-2013-0723.

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AbstractThree races of Pseudomonas syringaepv. tabaciTox+ (wildfire) (races 0, 1 and 2) and two races of Tox- (angular leaf spot) (races 1 and 2) have been confirmed on tobacco in Zimbabwe (Zim). Very few cultivars with no resistance to Ps. syringaepv. tabaci are grown commercially and race 0 has not been isolated since 1996. Because we no longer have a viable culture of race 0, we obtained an isolate of race 0 from Kentucky (0 KY), USA in January 2000. We included this isolate in race tests on standard indicator cultivars K E1 (susceptible to all races), KM 10 (resistance to race 0 derived from Nicotianalongiflora), WZ (resistance to races 0 and 1 derived from N. rustica) and a hybrid, K 35 (resistance to races 0 and 0 and 1 derived from N. longiflora and N. rustica respectively). Two leaves on 10-week-old seedlings were inoculated with a bacterial suspension (106 colony forming units [cfu] per mL) by spraying selected areas until just watersoaked and incubating the plants at 28 C and 70% RH for 10 d. The reaction to race 0, measured as lesion diameter, was different from that previously obtained with race 0 (Zim). Races 0 and 1 (Zim) are avirulent on WZ but race 0 (KY) was virulent. Further isolates of race 0 were received from Maryland (MD) and Tennessee (TN). The TN isolates overcame resistance derived from N. longiflora and N. rustica, except where both sets of genes were present in the same cultivar. Reactions have been variable with the race 0 (MD) isolate suggesting it is a mixed culture. We conclude that there are at least four races of Ps. syringaepv. tabaciTox+ worldwide and race 0 (KY) should be designated race 3. On all cultivars, race 2 consistently caused the largest lesions.
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Smits, Niels, Oğuzhan Öğreden, Mauricio Garnier-Villarreal, Caroline B. Terwee, and R. Philip Chalmers. "A study of alternative approaches to non-normal latent trait distributions in item response theory models used for health outcome measurement." Statistical Methods in Medical Research 29, no. 4 (March 11, 2020): 1030–48. http://dx.doi.org/10.1177/0962280220907625.

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It is often unrealistic to assume normally distributed latent traits in the measurement of health outcomes. If normality is violated, the item response theory (IRT) models that are used to calibrate questionnaires may yield parameter estimates that are biased. Recently, IRT models were developed for dealing with specific deviations from normality, such as zero-inflation (“excess zeros”) and skewness. However, these models have not yet been evaluated under conditions representative of item bank development for health outcomes, characterized by a large number of polytomous items. A simulation study was performed to compare the bias in parameter estimates of the graded response model (GRM), polytomous extensions of the zero-inflated mixture IRT (ZIM-GRM), and Davidian Curve IRT (DC-GRM). In the case of zero-inflation, the GRM showed high bias overestimating discrimination parameters and yielding estimates of threshold parameters that were too high and too close to one another, while ZIM-GRM showed no bias. In the case of skewness, the GRM and DC-GRM showed little bias with the GRM showing slightly better results. Consequences for the development of health outcome measures are discussed.
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Manji, Gulam Abbas, Zev A. Wainberg, Kartik Krishnan, Nick Giafis, Akshata Udyavar, Cheng Seok Quah, Jennifer Scott, et al. "ARC-8: Phase I/Ib study to evaluate safety and tolerability of AB680 + chemotherapy + zimberelimab (AB122) in patients with treatment-naive metastatic pancreatic adenocarcinoma (mPDAC)." Journal of Clinical Oncology 39, no. 3_suppl (January 20, 2021): 404. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.404.

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404 Background: AB680, a potent, selective small-molecule inhibitor of soluble and membrane-bound CD73, targets a major pathway of extracellular adenosine production with the aim of eliminating adenosine-mediated immunosuppression within the tumor microenvironment. In mPDAC, programmed cell death protein-1 (PD-1) axis inhibitors have limited clinical activity as monotherapies or combined with standard-of-care (SOC) chemotherapy. KRAS mutations, present in >90% of invasive PDACs, are associated with significantly elevated CD73 expression and poor clinical outcomes. Thus, mPDAC may be particularly sensitive to CD73 inhibition combined with SOC chemotherapy + anti–PD-1 antibody (zimberelimab [Zim]) treatment. Methods: ARC-8 (NCT04104672) is an ongoing phase 1b, dose escalation and expansion study in patients (pts) with treatment-naive mPDAC. In the dose escalation, AB680 (25, 50, 75, or 100 mg) is administered intravenously once every 2 weeks (Q2W) with standard doses of nab-paclitaxel/gemcitabine (NP/Gem) + Zim (240 mg) in a 3+3 design to determine the recommended dose for expansion (RDE). In the dose expansion, AB680 will be administered at the RDE with NP/Gem + Zim. Adverse events (AEs) and dose-limiting toxicities (DLTs) are recorded and graded per NCI CTCAE 5.0. AB680 pharmacokinetics, pharmacodynamics, and biomarker evaluations are also being performed throughout the study. Clinical activity is assessed every 8 weeks per RECIST v1.1. Results: As of 04SEPT2020, enrolled patients include 4 in Cohort 1 (25 mg AB680), 6 in Cohort 2 (50 mg AB680), and 3 in Cohort 3 (75 mg AB680). Initial AE profiles were similar to those observed for NP/Gem. The most common treatment-related AEs were fatigue (n=6, 43%), anemia (n=4, 29%), and neutrophil count decrease (n=4, 29%); anemia (n=2, 14%) was the most common treatment-related grade 3/4 AE. Initial pharmacodynamic data (50 mg dose) indicated excellent peripheral target coverage at AB680 trough concentrations. Best overall responses for 9 evaluable pts were 3 with partial response (1 in Cohort 1; 2 in Cohort 2), including a complete response of a target lesion, and 5 with stable disease (1 in Cohort 1; 4 in Cohort 2). One pt in Cohort 1 discontinued the study due to progressive disease. As of the cutoff date, 1 DLT (Grade 2 autoimmune hepatitis) occurred in Cohort 2; the event completely resolved with steroids and the pt was able to resume study treatment. No DLTs were reported in Cohort 3. Conclusions: Preliminary results from ARC-8 indicate that AB680, the first clinical-stage small-molecule CD73 inhibitor, in combination with SOC chemotherapy + Zim has a manageable safety profile consistent with that expected for each agent alone and demonstrates early signals of clinical activity. Dose escalation to 100 mg AB680 (Cohort 4) is ongoing to inform RDE selection. Clinical trial information: NCT04104672.
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Marsz, Andrzej A., and Anna Styszyńska. "Przebieg temperatury zim na obszarze Polski w latach 1720–2015." Prace Geograficzne 155 (2018): 85–138. http://dx.doi.org/10.4467/20833113pg.18.018.9541.

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Leitão, Rodrigo Machado Fernandes, Guilherme Augusto Pereira Malta, and Frederico Azevedo Lopes. "DEFINIÇÃO DE ZONAS DE INTERESSE METROPOLITANO COMO SUBSÍDIO PARA O PLANEJAMENTO AMBIENTAL NA REGIÃO METROPOLITANA DE BELO HORIZONTE." Caminhos de Geografia 20, no. 71 (August 8, 2019): 01–15. http://dx.doi.org/10.14393/rcg207140590.

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A proposta de Macrozoneamento da Região Metropolitana de Belo Horizonte (RMBH), ocorrida entre 2013-2015, deu legitimidade à intervenção e regulação do poder público sobre a dinâmica territorial, intermediando conflitos e conciliando interesses, por meio da delimitação de Zonas de Interesse Metropolitano (ZIM). Deste modo, busca-se estabelecer conjuntos de uso e apropriação do território conforme suas características intrínsecas, tendências e necessidades, associando formas de apropriação do território às dinâmicas atuais e futuras. Neste contexto, este trabalho tem por objetivo a delimitação e definição de parâmetros que possibilitem a identificação de áreas, ou zonas, com similitudes quanto às suas características ambientais, especialmente em relação à necessidade deconservação/preservação, recuperação e uso, que subsidiem a delimitação das ZIM. Foi utilizado a metodologia relativa aos processos de zoneamento ambiental, disponibilizada pelo Ministério do Meio Ambiente e a técnica de análise multicritérios, visando determinar o grau de semelhança e a compatibilidade entre as áreas previamente sugeridas no processo de macrozoneamento e aquelas identificadas neste estudo. Conclui-se que, diante do significativo número de áreas degradadas e/ou precariamente protegidas, torna-se fundamental a efetivação do planejamento, gestão e manejo das áreas verdes e de proteção ambiental visando à promoção da sustentabilidade socioeconômica da população que reside na RMBH.
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Dawson, Robert B. "PICC Zone Insertion Method™ (ZIM™): A Systematic Approach to Determine the Ideal Insertion Site for PICCs in the Upper Arm." Journal of the Association for Vascular Access 16, no. 3 (September 1, 2011): 156–65. http://dx.doi.org/10.2309/java.16-3-5.

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Abstract The consequences of random PICC practice can be serious and manifest as deep vein thrombosis, pulmonary embolism, catheter related bloodstream infection, and post thrombotic syndrome. Risk factors related to site selection have been well established for other central venous access devices, but not for ultrasound guided PICC insertion in the upper arm. The author presents observations of upper arm PICC insertion designated by color zones to highlight the variability of PICC practice. The author also details site risk factors associated with each color zone and proposes an ideal insertion location for upper arm ultrasound guided PICC procedures. The PICC Zone Insertion Method (ZIM) is a proposed system design for patient safety related to PICC insertions; performed by optimizing and organizing the clinical approach. It aids in identifying the Ideal Zone for upper arm needle insertion with ultrasound guidance. The significance of a systematic approach is that it is reproducible, measurable, and as a result will reduce variation in PICC insertion practice. The ZIM combines known mechanisms for vascular access insertion site complications with a systematic measuring and ultrasound scanning process, to reduce the impact of site risk factors. The impact of thrombosis cannot be underestimated, as it will likely limit the future use of veins for life saving vascular access. This issue should not be ignored by hospitals or clinicians, in fact, systematic solutions like PICC Zone Insertion Method, should be explored and supported as part of a comprehensive approach to vascular access care.
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Gurtowski, Maciej. "Cyfrowy wyścig zbrojeń w erze ekspansji kapitalizmu nadzoru." Forum Socjologiczne 10 (May 11, 2020): 104–13. http://dx.doi.org/10.19195/2083-7763.10.9.

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Amerykańska psycholog społeczna Shoshana Zuboff w swojej najnowszej książce The Age of Surveillance Capitalism nakreśliła kompleksową teorię tłumaczącą przemiany współczesnego ka-pitalizmu. Nazwała go „kapitalizmem nadzoru”, wskazując na kluczową rolę przemian w zakre-sie narzędzi kontroli społecznej. Celem niniejszego referatu jest uzupełnienie koncepcji „kapita-lizmu nadzoru” o wymiar wpływu opisywanych przez Zuboff procesów na sferę bezpieczeństwa. Rozważona zostanie hipoteza, że tak jak kapitalizm przemysłowy określał warunki brzegowe zim-nowojennego wyścigu zbrojeń, tak samo kapitalizm nadzoru Zuboff z koncepcji można interpreto-wać jako koło zamachowe procesu cyfrowego wyścigu zbrojeń.
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Siertsema, Gijsbert J. "English Metrical Psalms: Poetry as Praise and Prayer 1535-1601 Rivkah Zim." Huntington Library Quarterly 52, no. 4 (October 1989): 517–18. http://dx.doi.org/10.2307/3817160.

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Zhou, Kang, Hongliu Sun, and Wendy Hanna-Rose. "HIM-8 and ZIM zinc-finger proteins globally affect transcription factor activity." Developmental Biology 319, no. 2 (July 2008): 566. http://dx.doi.org/10.1016/j.ydbio.2008.05.351.

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Chini, Andrea, Sandra Fonseca, Jose M. Chico, Patricia Fernández-Calvo, and Roberto Solano. "The ZIM domain mediates homo- and heteromeric interactions between Arabidopsis JAZ proteins." Plant Journal 59, no. 1 (July 2009): 77–87. http://dx.doi.org/10.1111/j.1365-313x.2009.03852.x.

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Rigo, C., G. Carofano, F. Carpani, D. Trevisan, E. Finale, and G. Auletta. "The ZIM method: study of complications associated with PICC insertion site selection." Annals of Oncology 26 (October 2015): vi112. http://dx.doi.org/10.1093/annonc/mdv345.21.

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34

Pauwels, Laurens, Andrés Ritter, Jonas Goossens, Astrid Nagels Durand, Hongxia Liu, Yangnan Gu, Jan Geerinck, et al. "The RING E3 Ligase KEEP ON GOING Modulates JASMONATE ZIM-DOMAIN12 Stability." Plant Physiology 169, no. 2 (August 28, 2015): 1405–17. http://dx.doi.org/10.1104/pp.15.00479.

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Ullah, M. Habib, M. J. Uddin, T. A. Latef, W. N. L. Mahadi, M. T. Islam, M. R. Ahsan, and K. Kamardin. "ZIM cover for improvement of the bandwidth and gain of patch antenna." Current Applied Physics 16, no. 8 (August 2016): 837–42. http://dx.doi.org/10.1016/j.cap.2016.05.005.

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36

Zimmer, Amie. "A. Calcagno, Lived Experience from the Inside Out." Phenomenological Reviews 2 (2016): 14. http://dx.doi.org/10.19079/pr.2016.3.zim.

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Zimmermann, Anca, Radu A. Popp, Camelia Al-Khzouz, Simona Bucerzan, Ioana Naşcu, Daniel Leucuta, Peter R. Galle, and Paula Grigorescu-Sido. "Cholelithiasis in Patients with Gaucher Disease type 1: Risk Factors and the Role of ABCG5/ABCG8 Gene Variants." Journal of Gastrointestinal and Liver Diseases 25, no. 4 (December 1, 2016): 447–55. http://dx.doi.org/10.15403/jgld.2014.1121.254.zim.

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Background & Aim: Patients with Gaucher disease type 1 (GD1) show an altered lipid profile and a certain degree of insulin resistance, which might contribute to cholelithiasis (CL) and could possibly be associated with ABCG5/ABCG8 gene variants. We aimed to investigate the prevalence of CL in Caucasian adult patients with GD1 and the possible risk factors, including gene variants of the ABCG5/ABCG8 genes. Methods: 61 Caucasian patients with GD1 (38 female/23male), aged 18-62 years and 61 healthy subjects matched for age, gender and BMI, without CL, for comparison of lipid profiles. Data before start of enzyme replacement therapy (ERT) were recorded: clinical, haematological, severity parameters, splenectomy, genotype. Fasting lipid profiles before ERT, glycemia, insulinaemia, HOMA-IR at the last visit were documented. Genotyping for the gene variants D19H, Y54C, T400K, A632V (ABCG8); Q604E (ABCG5) was performed. Results: CL occurred in 45.9% of patients. Risk factors were: age, family history of CL, higher BMI values, LDL-cholesterol (LDL-C), disease severity, splenectomy. A specific dyslipidemia was found in patients vs. controls. Total serum cholesterol (TC) and LDL-C were higher in patients with CL than in those without; no obvious influence of insulin-resistance to lithogenesis was found. Patients with the GG genotype of D19H and the CC genotype of T400K (ABCG8 gene) had significantly higher levels of TC and LDL-C. Conclusion: Patients with GD1 showed an increased prevalence of CL, which was associated with common and disease-specific risk factors. Starting ERT soon after clinical onset and avoiding splenectomy might reduce the risk of CL in GD1. Abbreviations: ABC: ATP-binding cassette; CL: cholelithiasis; ERT: enzyme replacement therapy; GBA1: acid-beta-glucosidase gene; GD1: Gaucher disease type 1; HOMA-IR: homeostasis model-assessment insulin resistance; HDL-C: HDL-cholesterol; LDL-C: LDL-cholesterol; MN: multiples of normal; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; SSI: severity score index; TC: total cholesterol; TG: triglycerides.
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Zimmer, Vincent, and Frank Lammert. "The “two-devices-in-one-channel technique” for biliary through-the-scope stent removal." Journal of Gastrointestinal and Liver Diseases 26, no. 2 (June 1, 2017): 203–6. http://dx.doi.org/10.15403/jgld.2014.1121.262.zim.

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Zimmer, Thomas. "parmenides, Sein und Welt. Die Fragmente neu übersetzt und kommentiert von Helmuth Vetter." Bochumer Philosophisches Jahrbuch für Antike und Mittelalter 20 (December 31, 2017): 196–99. http://dx.doi.org/10.1075/bpjam.00009.zim.

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Zimmer, Thomas. "Markus gabriel, wolfram hogrebe, andreas speer (Hrsg.), Das neue Bedürfnis nach Metayphysik. The New Desire for Metaphysics." Bochumer Philosophisches Jahrbuch für Antike und Mittelalter 20 (December 31, 2017): 200–204. http://dx.doi.org/10.1075/bpjam.00010.zim.

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Zimmer, Thomas. "Tim Gollasch, Der Mythos von der Wirklichkeit. Eine Konfrontation des neurowissenschaftlichen Konstruktivismus mit Platons Philosophie." Bochumer Philosophisches Jahrbuch für Antike und Mittelalter 21 (December 31, 2018): 211–15. http://dx.doi.org/10.1075/bpjam.00029.zim.

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Zimmer, Thomas. "Benedikt Strobel, Georg Wöhrle, Hrsg., Xenophanes von Kolophon." Bochumer Philosophisches Jahrbuch für Antike und Mittelalter 22 (December 31, 2019): 214–16. http://dx.doi.org/10.1075/bpjam.00046.zim.

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43

Bramley, Helen, Rebecca Bitter, Gertraud Zimmermann, and Ulrich Zimmermann. "Simultaneous recording of diurnal changes in leaf turgor pressure and stem water status of bread wheat reveal variation in hydraulic mechanisms in response to drought." Functional Plant Biology 42, no. 10 (2015): 1001. http://dx.doi.org/10.1071/fp15087.

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Information about water relations within crop canopies is needed to improve our understanding of canopy resource distribution and crop productivity. In this study, we examined the dehydration/rehydration kinetics of different organs of wheat plants using ZIM-probes that continuously monitor water status non-destructively. ZIM-probes were clamped to the flag leaf and penultimate leaf of the same stem to monitor changes in turgor pressure, and a novel stem probe was clamped to the peduncle (just below the spike of the same stem) to monitor changes in stem water status. All organs behaved similarly under well-watered conditions, dehydrating and recovering at the same times of day. When water was withheld, the behaviour diverged, with the leaves showing gradual dehydration and incomplete recovery in leaf turgor pressure during the night, but the stem was affected to a lesser extent. Penultimate leaves were the most severely affected, reaching turgor loss point before the flag leaf. Upon rewatering, turgor pressure recovered but the output patch-pressure of the probes (Pp) oscillated at ~30 min periods in all organs of most plants (n = 4). Oscillations in Pp were attributed to oscillations in stomatal opening and appear to only occur above a threshold light intensity. The mechanisms identified in this study will be beneficial for crop productivity because the flag leaf is the source of most photoassimilates in developing grains, so the plant’s ability to maintain flag leaf hydration at the expense of older leaves should moderate the impact of drought on yield. Stomatal oscillations could increase water use efficiency as the plant attempts to rehydrate after drought.
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Xu, Dong-Bei, Ya-Nan Ma, Teng-Fei Qin, Wei-Lin Tang, Xi-Wu Qi, Xia Wang, Rui-Cen Liu, et al. "Transcriptome-Wide Identification and Characterization of the JAZ Gene Family in Mentha canadensis L." International Journal of Molecular Sciences 22, no. 16 (August 17, 2021): 8859. http://dx.doi.org/10.3390/ijms22168859.

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Jasmonate ZIM-domain (JAZ) proteins are the crucial transcriptional repressors in the jasmonic acid (JA) signaling process, and they play pervasive roles in plant development, defense, and plant specialized metabolism. Although numerous JAZ gene families have been discovered across several plants, our knowledge about the JAZ gene family remains limited in the economically and medicinally important Chinese herb Mentha canadensis L. Here, seven non-redundant JAZ genes named McJAZ1–McJAZ7 were identified from our reported M. canadensis transcriptome data. Structural, amino acid composition, and phylogenetic analysis showed that seven McJAZ proteins contained the typical zinc-finger inflorescence meristem (ZIM) domain and JA-associated (Jas) domain as conserved as those in other plants, and they were clustered into four groups (A-D) and distributed into five subgroups (A1, A2, B1, B2, and D). Quantitative real-time PCR (qRT-PCR) analysis showed that seven McJAZ genes displayed differential expression patterns in M. canadensis tissues, and preferentially expressed in flowers. Furthermore, the McJAZ genes expression was differentially induced after Methyl jasmonate (MeJA) treatment, and their transcripts were variable and up- or down-regulated under abscisic acid (ABA), drought, and salt treatments. Subcellular localization analysis revealed that McJAZ proteins are localized in the nucleus or cytoplasm. Yeast two-hybrid (Y2H) assays demonstrated that McJAZ1-5 interacted with McCOI1a, a homolog of Arabidopsis JA receptor AtCOI1, in a coronatine-dependent manner, and most of McJAZ proteins could also form homo- or heterodimers. This present study provides valuable basis for functional analysis and exploitation of the potential candidate McJAZ genes for developing efficient strategies for genetic improvement of M. canadensis.
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Sen, Saswati, and Maitrayee DasGupta. "Involvement of Arachis hypogaea Jasmonate ZIM domain/TIFY proteins in root nodule symbiosis." Journal of Plant Research 134, no. 2 (February 8, 2021): 307–26. http://dx.doi.org/10.1007/s10265-021-01256-w.

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Marič, Leon, Ilse Cleenwerck, Tomaž Accetto, Peter Vandamme, and Janja Trček. "Description of Komagataeibacter melaceti sp. nov. and Komagataeibacter melomenusus sp. nov. Isolated from Apple Cider Vinegar." Microorganisms 8, no. 8 (August 3, 2020): 1178. http://dx.doi.org/10.3390/microorganisms8081178.

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Two novel strains AV382 and AV436 were isolated from a submerged industrial bioreactor for production of apple cider vinegar in Kopivnik (Slovenia). Both strains showed very high (≥98.2%) 16S rRNA gene sequence similarities with Komagataeibacter species, but lower 16S–23S rRNA gene internal transcribed spacer (ITS). The highest similarity of the 16S–23S rRNA gene ITS of AV382 was to Komagataeibacter kakiaceti LMG 26206T (91.6%), of AV436 to Komagataeibacter xylinus LMG 1515T (93.9%). The analysis of genome sequences confirmed that AV382 is the most closely related to K. kakiaceti (ANIb 88.2%) and AV436 to K. xylinus (ANIb 91.6%). Genome to genome distance calculations exhibit for both strains ≤47.3% similarity to all type strains of the genus Komagataeibacter. The strain AV382 can be differentiated from its closest relatives K. kakiaceti and Komagataeibacter saccharivorans by its ability to form 2-keto and 5-keto-D-gluconic acids from glucose, incapability to grow in the presence of 30% glucose, formation of C19:0 cyclo ω8c fatty acid and tolerance of up to 5% acetic acid in the presence of ethanol. The strain AV436 can be differentiated from its closest relatives K. xylinus, Komagataeibacter sucrofermentans, and Komagataeibacter nataicola by its ability to form 5-keto-D-gluconic acid, growth on 1-propanol, efficient synthesis of cellulose, and tolerance to up to 5% acetic acid in the presence ethanol. The major fatty acid of both strains is C18:1ω7c. Based on a combination of phenotypic, chemotaxonomic and phylogenetic features, the strains AV382T and AV436T represent novel species of the genus Komagataeibacter, for which the names Komagataeibactermelaceti sp. nov. and Komagataeibacter melomenusus are proposed, respectively. The type strain of Komagataeibacter melaceti is AV382T (= ZIM B1054T = LMG 31303T = CCM 8958T) and of Komagataeibacter melomenusus AV436T (= ZIM B1056T = LMG 31304T = CCM 8959T).
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Rwafa, Urther, Washington Mushore, and Ephraim Vhutuza. "TOWARDS PEACE, HEALING AND RECONCILIATION IN ZIM-BABWE: THEATRICALISING POLITICAL VIOLENCE THROUGH RITUALS (2011)." Imbizo 5, no. 2 (June 23, 2017): 23–39. http://dx.doi.org/10.25159/2078-9785/2843.

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This paper explores the reconciliatory possibilities of the theatrical piece Rituals (2011) penned by Stephen Chifunyise and directed and produced by Daves Guzha. The Rituals’ theatrical piece memorialises as well as condemns a culture of violence demonstrated during the 2008 harmonised elections in Zimbabwe. Through “ritualized” performance, a community embarks on a metaphysical journey focused on exorcising the ghosts of political violence still haunting individuals, communities, politicians, and the nation as a whole. These day-to-day modes of healing and reconciliation, dramatised through Rituals, suggest that communities can create platforms for peace, cultivate tolerance and permit dialogue to prevail if victims are brought face-to-face with perpetrators of violence with the hope of ironing out political differences. It is going to be argued in this paper that although the political drama in Rituals, centralises politicians as major culprits that fomented violence, its failure to go beyond political meta-narratives constricts its capacity to explore the complexities of violence in Zimbabwe. These complexities are informed by factors such as lack of voter education, existence of age-old grudges, and fragmentation of community values, among others. Another critical strand to be explored in this article is one that interrogates Rituals’ potential to reach out to the wider audiences at grassroots levels, since the political drama in Rituals speaks to the “upper class” and intellectual circles, thereby foreclosing critical debate and “voices” that should emerge from “below” which are communi­ties many of whom were directly involved. By adopting a down-top methodological approach, the article seeks to place communities at the forefront in confronting questions of violence, peace-building and reconciliation in Zimbabwe.
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Sun, Heng, Lin Chen, Jianying Li, Meiling Hu, Abid Ullah, Xin He, Xiyan Yang, and Xianlong Zhang. "The JASMONATE ZIM-Domain Gene Family Mediates JA Signaling and Stress Response in Cotton." Plant and Cell Physiology 58, no. 12 (October 3, 2017): 2139–54. http://dx.doi.org/10.1093/pcp/pcx148.

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Gulur Sadananda, Karthikeya, Mahesh P. Abegaonkar, and Shiban K. Koul. "Gain Equalized Shared-Aperture Antenna Using Dual-Polarized ZIM for mmWave 5G Base Stations." IEEE Antennas and Wireless Propagation Letters 18, no. 6 (June 2019): 1100–1104. http://dx.doi.org/10.1109/lawp.2019.2910183.

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Major, Ian T., Yuki Yoshida, Marcelo L. Campos, George Kapali, Xiu-Fang Xin, Koichi Sugimoto, Dalton de Oliveira Ferreira, Sheng Yang He, and Gregg A. Howe. "Regulation of growth-defense balance by the JASMONATE ZIM-DOMAIN (JAZ)-MYC transcriptional module." New Phytologist 215, no. 4 (June 26, 2017): 1533–47. http://dx.doi.org/10.1111/nph.14638.

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