Academic literature on the topic 'ZNF687'

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Journal articles on the topic "ZNF687"

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Divisato, Giuseppina, Daniela Formicola, Teresa Esposito, et al. "ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor." American Journal of Human Genetics 98, no. 2 (2016): 275–86. http://dx.doi.org/10.1016/j.ajhg.2015.12.016.

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Scotto di Carlo, Federica, Laura Pazzaglia, Steven Mumm, et al. "ZNF687 Mutations in an Extended Cohort of Neoplastic Transformations in Paget's Disease of Bone: Implications for Clinical Pathology." Journal of Bone and Mineral Research 35, no. 10 (2020): 1974–80. http://dx.doi.org/10.1002/jbmr.3993.

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Divisato, G., F. Scotto di Carlo, N. Petrillo, T. Esposito, and F. Gianfrancesco. "ZNF687 mutations are frequently found in pagetic patients from South Italy: implication in the pathogenesis of Paget's disease of bone." Clinical Genetics 93, no. 6 (2018): 1240–44. http://dx.doi.org/10.1111/cge.13247.

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Turelli, Priscilla, Christopher Playfoot, Dephine Grun, et al. "Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons." Science Advances 6, no. 35 (2020): eaba3200. http://dx.doi.org/10.1126/sciadv.aba3200.

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In the first days of embryogenesis, transposable element–embedded regulatory sequences (TEeRS) are silenced by Kruppel-associated box (KRAB) zinc finger proteins (KZFPs). Many TEeRS are subsequently co-opted in transcription networks, but how KZFPs influence this process is largely unknown. We identify ZNF417 and ZNF587 as primate-specific KZFPs repressing HERVK (human endogenous retrovirus K) and SVA (SINE-VNTR-Alu) integrants in human embryonic stem cells (ESCs). Expressed in specific regions of the human developing and adult brain, ZNF417/587 keep controlling TEeRS in ESC-derived neurons an
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Liu, Yi, Wei Yin, Jingwen Wang, et al. "KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly." Cells 8, no. 12 (2019): 1604. http://dx.doi.org/10.3390/cells8121604.

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Despite progress in understanding how virus-induced, NF-κB-dependent pro-inflammatory cytokines are regulated, there are still factors and mechanisms that remain to be explored. We aimed to uncover the relationship between KRAB-zinc finger protein ZNF268a and NF-κB-mediated cytokine production in response to viral infection. To this end, we established a ZNF268a-knockout cell line using a pair of sgRNAs that simultaneously target exon 3 in the coding sequence of the ZNF268 gene in HEK293T. HEK293T cells lacking ZNF268a showed less cytokine expression at the transcription and protein levels in
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Cheng, Ke, Zhizhao Chen, Lian Liu, et al. "ZNF667 Serves as a Putative Oncogene in Human Hepatocellular Carcinoma." Cellular Physiology and Biochemistry 41, no. 6 (2017): 2523–33. http://dx.doi.org/10.1159/000475971.

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Background/Aims: Zinc finger protein 667 (ZNF667) is a member of C2H2 zinc finger protein family. For the first time, we aim to analyze the expression pattern of ZNF667 in hepatocellular carcinoma (HCC) tissues; to explore its role in HCC tumorigenesis. Methods: Immuno-histochemistry was carried out to characterize the ZNF667 expression in paraffin-embedded HCC samples. The relationship between ZNF667 expression and the clinical, pathological data of the patients were analyzed. Human normal hepatocyte cells LO2 over expressing ZNF667 (LO2-ZNF667 cells), ZNF667 depleted hepatocellular carcinoma
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Yuan, Qin, Chao Gao, Xiao-dong Lai, Liang-yi Chen, and Tian-bao Lai. "Analysis of Long Noncoding RNA ZNF667-AS1 as a Potential Biomarker for Diagnosis and Prognosis of Glioma Patients." Disease Markers 2020 (November 16, 2020): 1–7. http://dx.doi.org/10.1155/2020/8895968.

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Objective. Long noncoding RNAs (lncRNAs) have been strongly associated with various types of cancer. The present study aimed at exploring the diagnostic and prognostic value of lncRNA Zinc finger protein 667-antisense RNA 1 (ZNF667-AS1) in glioma patients. Patients and Methods. The expressions of ZNF667-AS1 were detected in 155 glioma tissues and matched normal brain tissue samples by qRT-PCR. The receiver operating characteristic (ROC) curve was performed to estimate the diagnostic value of ZNF667-AS1. The association between the ZNF667-AS1 expression and clinicopathological characteristics w
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Siraj, Abdul K., Pratheesh Kumar Poyil, Sandeep Kumar Parvathareddy, et al. "Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients." International Journal of Molecular Sciences 22, no. 15 (2021): 7833. http://dx.doi.org/10.3390/ijms22157833.

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Thyroid cancer incidence has increased in recent decades. Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Approximately 30% of PTC patients develop recurrence or distant metastasis and tend to have poor prognosis. Therefore, the identification of targetable biomarkers in this subset of patients is of great importance. Accumulating evidence indicates that zinc finger protein 677 (ZNF677), which belongs to the zinc finger protein family, is an important effector during the progression of multiple malignancies. However, its role in Middle Eastern PTC patients has not
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Ishikawa, S., M. Kai, Y. Takei, et al. "Isolation and mapping of a human zinc finger gene (ZNF188) homologous to ZNF187, a serum-response-element binding protein." Cytogenetic and Genome Research 77, no. 3-4 (1997): 185–89. http://dx.doi.org/10.1159/000134572.

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Di Fiore, Riccardo, Sherif Suleiman, Rosa Drago-Ferrante, et al. "LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?" International Journal of Molecular Sciences 22, no. 15 (2021): 7829. http://dx.doi.org/10.3390/ijms22157829.

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Gynecological cancers (GCs) are currently among the major threats to female health. Moreover, there are different histologic subtypes of these cancers, which are defined as ‘rare’ due to an annual incidence of <6 per 100,000 women. The majority of these tend to be associated with a poor prognosis. Long non-coding RNAs (lncRNAs) play a critical role in the normal development of organisms as well as in tumorigenesis. LncRNAs can be classified into tumor suppressor genes or oncogenes, depending on their function within the cellular context and the signaling pathways in which they are involved.
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Dissertations / Theses on the topic "ZNF687"

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Hahn, Stefanie. "Characterization of ZNF281 and its role in colorectal carcinogenesis." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-177446.

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The vast majority of colorectal cancer (CRC)-related deaths is caused by the metastatic spread of tumor cells to distant organs rather than by the growth of the primary tumor. However, until today the mechanisms involved in CRC metastasis are not completely understood. For cancer cells the epithelial-mesenchymal transition (EMT) is thought to represent a prerequisite to invade adjacent tissue and form metastases at distant sites. Transcription factors, cytokines or oncogenic signaling pathways play an important role in the regulation of the EMT program. Recently, the oncoprotein c-MYC was show
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Nguyen, Thanh Nhan. "Deeper insights into the deleterious roles of ZNF217 in tumorigenesis and the identification of a novel and functional interplay between ZNF217 and ERalpha in breast cancer." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10331.

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ZNF217 est un oncogène potentiel codant pour un facteur de transcription Krüppel-like. Cette étude vise à explorer le rôle délétère et la valeur pronostique de ZNF217 dans le cancer du sein. Nos résultats ont montré que : (i) des niveaux d'expression élevés de ZNF217 (tant au niveau de l'ARNm qu'au niveau protéique) sont associés à un mauvais pronostic chez les patientes atteintes d'un cancer du sein, et plus particulièrement dans les cancers du sein de type ER+/Luminaux/Luminaux A ; (ii) ZNF217 induit la transition épithélio mésenchymateuse (EMT) dans les cellules épithéliales mammaires humai
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Bellanger, Aurélie. "ZNF217, un rôle majeur dans le cancer du sein : un nouvel instigateur du développement de métastases ostéolytiques : isoforme ZNF217-ΔE4 : implication en cancérogénèse mammaire et valeur pronostique". Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1007.

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ZNF217 est un oncogène codant pour un facteur de transcription de la famille Krüppel-like. Nos objectifs sont d'explorer le rôle de l'oncogène ZNF217 dans le développement de métastases du cancer du sein à tropisme osseux et la valeur pronostique ainsi que les fonctions d'une nouvelle isoforme de ZNF217. Nous avons identifié que de forts niveaux d'expression de l'ARNm de ZNF217 dans les tumeurs primitives du sein pourrait être un indicateur d'un développement ultérieur de métastases osseuses. Nous avons montré que ZNF217 est un nouvel activateur de la voie BMP et que l'inhibition de cette voie
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France, Benoît. "Étude du rôle des facteurs MYSM1 et ZNF699 dans la réparation de l'ADN." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB072.

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Au cours des 20 dernières années, d'importantes connaissances ont été acquises concernant les implications de la réponse aux dommages de l'ADN (DDR) dans le développement, la maturation et la fonction du système immunitaire. Le laboratoire DGSI a contribué à cette aventure en montrant que, en effet, des défauts dans la DDR peuvent entraîner des déficits immunitaires et, dans certains cas, une prédisposition au cancer. La première partie de la thèse est basée sur l'analyse d'un patient présentant un déficit immunitaire et des anomalies du développement. Une mutation faux-sens homozygote affecta
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Ogo, Ogo Agbor. "Cellular responses to zinc involving the transcription factor ZNF658 and its target genes." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2752.

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Zinc is an essential trace element that plays a crucial role in catalytic, structural and regulatory functions of many proteins including enzymes and transcription factors; thus maintenance of zinc balance is critical for normal cellular function. Cellular mechanisms that maintain zinc balance include the regulation of genes coding for proteins that play vital roles in zinc homeostasis. These proteins include zinc transporters belonging to the ZIP (SLC39A) and ZnT (SLC30A) families as well as the zinc-binding metallothionein proteins. In contrast to bacterial and yeast systems, a transcription
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Hahn, Stefanie [Verfasser], and Heiko [Akademischer Betreuer] Hermeking. "Characterization of ZNF281 and its role in colorectal carcinogenesis / Stefanie Hahn. Betreuer: Heiko Hermeking." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1065610114/34.

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Spree, Matthias [Verfasser]. "Einfluss von Zinkfingerprotein 580 (ZNF580) auf Matrixmetalloprotease-1 (MMP-1) in humanen Podozyten / Matthias Spree." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1228859809/34.

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Phillips, Kelsey. "CRISPR-Cas9 Transfection Optimization and Use in a Forward Genetic Screen to Identify Telomere Length Maintenance Genes." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7357.

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Mutations in the telomere length maintenance pathway can lead to a spectrum of diseases called telomere syndromes, however, the pathway is not fully understood and there may still be unknown components. We designed a forward genetic screen to identify new genes involved in telomere length maintenance. Of the top ranked genes, ZNF827, a zinc finger protein, is the most promising candidate gene. The possible discovery of a new component involved in telomere length maintenance increases our understanding of the pathway and opens new avenues of research. Recent advances in molecular biology techni
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Thollet, Aurélie. "Rôle de ZNF217, un nouvel oncogène dans le cancer du sein : rôle dans l'échappement tumoral et valeur pronostique." Phd thesis, Université Claude Bernard - Lyon I, 2011. http://tel.archives-ouvertes.fr/tel-00862607.

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ZNF217, un nouveau membre de la famille krüppel-like, est un facteur de transcription qui interagit avec des co-répresseurs et des protéines modifiant les histones suggérant que ZNF217 ferait partie d'un complexe répresseur de la transcription. ZNF217 serait un oncogène mais ses fonctions sont encore mal connues à l'heure actuelle. Les objectifs de ce travail ont été d'étudier le rôle de ZNF217 dans l'échappement tumoral et sa valeur pronostique dans le cancer du sein. Ainsi, nous avons montré que de forts niveaux d'expression de ZNF217 sont associés à : (i) une augmentation de la prolifératio
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Thollet, Aurélie. "Rôle de ZNF217, un nouvel oncogène dans le cancer du sein : rôle dans l’échappement tumoral et valeur pronostique." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10326/document.

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ZNF217, un nouveau membre de la famille krüppel-like, est un facteur de transcription qui interagit avec des co-répresseurs et des protéines modifiant les histones suggérant que ZNF217 ferait partie d’un complexe répresseur de la transcription. ZNF217 serait un oncogène mais ses fonctions sont encore mal connues à l’heure actuelle. Les objectifs de ce travail ont été d’étudier le rôle de ZNF217 dans l’échappement tumoral et sa valeur pronostique dans le cancer du sein. Ainsi, nous avons montré que de forts niveaux d’expression de ZNF217 sont associés à : (i) une augmentation de la prolifératio
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Conference papers on the topic "ZNF687"

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Messana, Matthew J., Chao Yang, and Laurie E. Littlepage. "Abstract 4252: Regulation of the oncogene ZNF217 by localization in breast cancer." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4252.

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Messana, Matthew J., and Laurie E. Littlepage. "Abstract 1979: Regulation of the oncogene ZNF217 by localization in breast cancer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1979.

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Furukawa, Daisuke, Tsuyoshi Chijiwa, Masahiro Matsuyama, et al. "Abstract 1543: Clinical significance of ZNF185 intracellular localization in pancreatic ductal carcinoma." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1543.

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Suarez, Christopher, Sunil S. Badve, and Laurie E. Littlepage. "Abstract B47: The role of ZNF217 in the development of breast cancer chemoresistance." In Abstracts: AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; June 18-21, 2014; Orlando, FL. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.pms14-b47.

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Nolte, Elke, Jaroslaw Szczyrba, Martin Hart, et al. "Abstract 3090: miR-24 influences proliferation of prostate cancer cellsin vitrovia targeting ZNF217." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-3090.

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Facchine, Beth, Junmin Wu, Megan Fabry, Matt Messana, William Kaliney, and Laurie Littlepage. "Abstract 3341: Inhibiting the destruction of the oncogene ZNF217 promotes breast cancer metastasis to lung." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3341.

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Tbaishat, Rana, Songping Wang, and Bernard Kwabi-Addo. "Abstract 1985: ZNF783, a novel zinc finger protein has tumor suppressor function in prostate cancer." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1985.

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Priese, J., A.-B. Hums, T. Erler, et al. "ZNF671 als epigenetischen Krebsmarker zur Detektion von Kopf-Hals-Tumoren mittels quantitativeR real-time- PCR." In 100 JAHRE DGHNO-KHC: WO KOMMEN WIR HER? WO STEHEN WIR? WO GEHEN WIR HIN? Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1727863.

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Nameki, Robbin, Marcos A. S. Fonseca, Jessica Reddy, et al. "Abstract GMM-042: PAN-CANCER TRANSCRIPTION FACTOR ANALYSES IDENTIFY ZNF217 AS A NOVEL DRIVER IN HGSOC." In Abstracts: 12th Biennial Ovarian Cancer Research Symposium; September 13-15, 2018; Seattle, Washington. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1557-3265.ovcasymp18-gmm-042.

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Martín-Sánchez, E., R. Guarch, I. Blanco-Luquin, et al. "PO-388 Epigenetic silencing of ZNF177 by MIR-877–3 p could be involved in cervical cancer progression." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.415.

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Reports on the topic "ZNF687"

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Gregg, Jeffrey P., and Sheryl R. Krig. The ZNF217 Breast Cancer Oncogene Amplified at 20q13: A Potential Marker for Invasiveness. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada564327.

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