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1

Sham, Robin, and Arie Monster. "Zwolle Cable-Stayed Bridge, The Netherlands." Structural Engineering International 9, no. 2 (1999): 92–93. http://dx.doi.org/10.2749/101686699780621145.

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Oskam, Jacques, and Annemiek Stienstra. "Community-based wound care in the Netherlands: Implementing a regional network for wound care." Journal of the European Wound Management Association November 2020 21, Issue 1 Volume 21, 2020 (2020): 61–67. http://dx.doi.org/10.35279/jewma202011.09.

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The transition of hospital care to primary care is one of the mainstays of national health care policy in the Netherlands. This paper presents the results of a successful initiative to establish a regional community-based wound care network in the Zwolle region of the Netherlands.
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de Haan, Gerrit-Jan, Roland Thijs, Charles Deckers, Ilonka Wildenberg, and Cassandra van Laerhoven. "Epilepsy Foundation of the Netherlands (Stichting Epilepsie Instellingen Nederland [SEIN]), Heemstede and Zwolle, The Netherlands." Epilepsy & Behavior 76 (November 2017): S35—S38. http://dx.doi.org/10.1016/j.yebeh.2017.07.027.

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Aalders, Maarten J. "trouwe vriend van Hongarije: Ds. Han Munnik (1884–1969)." Acta Neerlandica, no. 16-17 (March 1, 2021): 37–52. http://dx.doi.org/10.36392/actaneerl/2020/16-17/3.

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From 1921 on, the Reformed Churches in the Netherlands had a study fund, especially for Hungarian students. Until the Second World War, about 40 students studied with funding from that scholarship, neatly distributed between the Free University and the Theological School in Kampen. The chairman of the fund was Prof. F.W. Grosheide (1881–1972) of the Free University, its secretary was Rev. H.A. Munnik (1884–1969), from Zwolle. Both were involved in the fund from 1921 on, Grosheide retired in 1952, Munnik a few years later. Munnik became an honorary member of the Association of Hungarian Pastors and Honorary Professor in Debrecen (1938), Grosheide became Honorary Doctor in Sárospatak (1931), Debrecen (1938), and Budapest (1946). This indicates their significance for the Hungarian ministerial corps and for the contacts between Hungary and the Netherlands in those years.
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Sass-Klaassen, U., and E. Hanraets. "Woodlands of the past — The excavation of wetland woods at Zwolle-Stadshagen (the Netherlands): Growth pattern and population dynamics of oak and ash." Netherlands Journal of Geosciences - Geologie en Mijnbouw 85, no. 1 (2006): 61–71. http://dx.doi.org/10.1017/s0016774600021429.

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AbstractDendrochronology has been used to date sub-fossil wood excavated from former wetland woods located in Zwolle-Stadshagen, the Netherlands. Tree-ring analysis was performed on oak and ash to gain insight into changes in the growth dynamics of the trees resulting from changes in external site conditions, particularly hydrology. In addition population dynamics of oak and ash were studied by observing the temporal distribution and mean age of the oak and ash trees in the period when the woodland existed. The results showed that woodlands with oak and ash at Zwolle-Stadshagen existed at least for a period of about 700 years, from ca. 150 BC to AD 580 (ca. 2200 - 1400 cal. BP). The oak and ash were slowly growing and showed alternating phases of normal and depressed growth. Growth depressions occurred with a frequency of about 20 to 40 years. Almost all of these depressions were synchronous with those in oaks from other - mainly wetland areas - in NW Europe. Consequently, a regional (climate) factor must be considered responsible for this phenomenon. By taking into account the specific growth conditions in wetland woods it is very likely that this factor is linked to site hydrology. Around AD 300 (ca. 1650 cal. BP) a remarkable shift in population dynamics occurred in both oak and ash with many new trees establishing. This indicates a period of striking changes in site hydrology preceding the collapse of the woodland starting around AD 530 (ca. 1420 cal. BP).
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Boone, C., A. Brouwer, J. Jacobs, A. van Witteloostuijn, and M. de Zwaan. "Religious Pluralism and Organizational Diversity: An Empirical Test in the City of Zwolle, the Netherlands, 1851-1914." Sociology of Religion 73, no. 2 (2011): 150–73. http://dx.doi.org/10.1093/socrel/srr034.

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7

Constandse-Westermann, T. S. "Age estimation by dental attrition in an independently controlled early 19th century sample from Zwolle, The Netherlands." Human Evolution 12, no. 4 (1997): 269–85. http://dx.doi.org/10.1007/bf02438180.

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8

Steendam, Gosse Jan, Jentsje W. Van der Meer, Bianca Hardeman, and André Van Hoven. "DESTRUCTIVE WAVE OVERTOPPING TESTS ON GRASS COVERED LANDWARD SLOPES OF DIKES AND TRANSITIONS TO BERMS." Coastal Engineering Proceedings 1, no. 32 (2011): 8. http://dx.doi.org/10.9753/icce.v32.structures.8.

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In 2009 tests have been performed at the Afsluitdijk, the closure dike of Lake IJssel in the Netherlands. This dike has a sand core covered by layers of clay and boulder clay, and a grass cover. In 2010 succeeding tests were performed at a river dike near Zwolle. This dike was a sand dike with a grass cover. In all of these tests research was performed on the behaviour of the grass cover on the landward slope of the dikes. Furthermore, the influence on erodibility of the grass cover caused by damage of the grass cover by mice, moles or other influences like tractor tracks were investigated. Also the influence of obstacles or other elements, which may be present at dikes, was part of the investigations (tree, stairs, fence, maintenance road). It was observed that all of these influences are to some extent contributing to a decrease of the resistance against failure.
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Sass-Klaassen, U., I. Poole, T. Wils, G. Helle, G. H. Schleser, and P. F. van Bergen. "Carbon and Oxygen Isotope Dendrochronology in Sub-Fossil Bog Oak Tree Rings - A Preliminary Study." IAWA Journal 26, no. 1 (2005): 121–36. http://dx.doi.org/10.1163/22941932-90001607.

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Isotope dendroclimatology is a relatively new field investigating environmental factors that control the radial growth of trees. Tree-ring series of sub-fossil bog oaks can be dated from sites across northwest Europe indicating that the environmental change(s) were regional rather than local. Bog oaks show characteristic periods of suppressed growth thought to have resulted from changes in the hydrological status of bogs towards either wetter or drier conditions. This study investigates relative changes in stable carbon (δ13C) and oxygen (δ18O) isotope content in phases of suppressed and normal growth in three bog oaks dated as c. 200 BC to 150 AD from Zwolle, eastem Netherlands. Bog oaks show no clear relationship between tree-ring width and isotopic composition although one tree exhibited relatively depleted values of l3C and 18O with suppressed growth. Suppressed ring growth is characterised by the formation of earlywood only, possibly as a result ofhydrologic alterations that limited the formation of latewood, which would otherwise have locked up a detectable signal in stable isotopic shift.
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de Vries, Marsha, and Ronald Wolbink. "Transition and transformation in youth care in the Netherlands." International Journal of Public Leadership 14, no. 2 (2018): 96–108. http://dx.doi.org/10.1108/ijpl-07-2017-0028.

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Purpose Since January 2015, the Dutch youth care system has been under construction. Its focus has shifted from the problematic to the normal development of children. Emphasis on the capacities of both youths and parents, on customized care and on better cooperation between professionals should decrease the use of specialized services. This reconstruction of the youth care system not only appeals to the competencies and skills of professionals, but also requires innovations in terms of leadership. The purpose of this paper is to describe the struggle managers face when working to transform the youth care system, and to provide some suggestions for how managers can be supported. Design/methodology/approach This paper is based on the results of two empirical, qualitative studies that were recently conducted by the Research Institute Youth, which is part of the Health Care and Social Work Research Centre of Windesheim University of Applied Sciences in Zwolle, the Netherlands. Over the course of a preliminary study, executive managers of five youth care organizations were interviewed on the ongoing transformations of their organizations and the changing roles and needs of managers within these transformations. Subsequently, 13 middle- and first-line managers of 3 youth care organizations were interviewed about their experiences and the ways in which they have handled the new roles they have taken on in transforming their organizations. Findings The management of youth care organizations is responsible for facilitating professionals in taking on and shaping their new roles, thus affecting not only the structure but also the culture and practices of youth care organizations and of management itself. This research shows that managers are struggling with these changes in their own ways. While youth care managers are struggling with their new roles and responsibilities, the intended transformation of the youth care system lags behind. Appropriate support of managers is essential, but is currently lacking. This paper provides some suggestions for how managers can be supported. Originality/value This paper identifies and explains the challenges that top-, middle- and lower-level managers face in current transformation processes in social service organizations, and provides some suggestions for how managers can be supported in these processes.
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van den Dries, Carline J., Ruud Oudega, Arif Elvan, et al. "Integrated management of atrial fibrillation including tailoring of anticoagulation in primary care: study design of the ALL-IN cluster randomised trial." BMJ Open 7, no. 9 (2017): e015510. http://dx.doi.org/10.1136/bmjopen-2016-015510.

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IntroductionIn our ageing society, we are at the merge of an expected epidemic of atrial fibrillation (AF). AF management requires an integrated approach, including rate or rhythm control, stroke prevention with anticoagulation and treatment of comorbidities such as heart failure or type 2 diabetes. As such, primary care seems to be the logical healthcare setting for the chronic management of patients with AF. However, primary care has not yet played a dominant role in AF management, which has been in fact more fragmented between different healthcare providers. This fragmentation might have contributed to high healthcare costs. To demonstrate the feasibility of managing AF in primary care, studies are needed that evaluate the safety and (cost-)effectiveness of integrated AF management in primary care.Methods and analysisThe ALL-IN trial is a multicentre, pragmatic, cluster randomised, non-inferiority trial performed in primary care practices in a suburban region in the Netherlands. We aim to include a minimum of 1000 patients with AF aged 65 years or more from around 18 to 30 practices. Duration of the study is 2 years. Practices will be randomised to either the intervention arm (providing integrated AF management, involving a trained practice nurse and collaboration with secondary care) or the control arm (care as usual). The primary endpoint is all-cause mortality. Secondary endpoints are cardiovascular mortality, (non)-cardiovascular hospitalisation, major adverse cardiac events, stroke, major bleeding, clinically relevant non-major bleeding, quality of life and cost-effectiveness.Ethics and disseminationThe protocol was approved by the Medical Ethical Committee of the Isala Hospital Zwolle, the Netherlands. Patients in the intervention arm will be asked informed consent for participating in the intervention. Results are expected in 2019 and will be disseminated through both national and international journals and conferences.Trial registration numberThis trial is registered at the Netherlands Trial Register (NTR5532).
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Swan, Claudia. "Eric Jorink; Bart Ramakers (Editors). Art and Science in the Early Modern Netherlands. (Netherlands Yearbook for History and Art, 61.) 367 pp., illus., bibls. Zwolle: WBOOKS, 2011. €107 (cloth)." Isis 107, no. 1 (2016): 161–63. http://dx.doi.org/10.1086/686196.

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Draaisma, Eelco, Jolita Bekhof, Veerle J. Langenhorst, and Paul L. P. Brand. "Implementing evidence-based medicine in a busy general hospital department: results and critical success factors." BMJ Evidence-Based Medicine 23, no. 5 (2018): 173–76. http://dx.doi.org/10.1136/bmjebm-2018-110895.

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Implementing evidence-based medicine (EBM) in a busy hospital department is challenging, but when successful, may contribute to quality of care. This paper is a narrative review of the successes and challenges of deliberate implementation of EBM in a paediatric department in a general teaching hospital in Zwolle, the Netherlands. Key elements in this project were providing basic EBM education to the entire team of consultants and nurse practitioners, structurally embedding EBM activities into our weekly schedule and development of local practice guidelines. This deliberate practice of EBM principles has changed the way we treat common paediatric problems. It likely reduced unwarranted practice variation and promoted a reserved attitude towards the use of unnecessary diagnostics, which might improve delivery of effective, cost-conscious care. The project also positively influenced our group culture and learning environment. In accordance with previous reports, lack of time and reluctance to change routines and habits hindered the practice of EBM in our department. In our experience, these barriers can be overcome by promoting a team-wide endorsement of EBM, a willingness to acknowledge uncertainty and by deliberate practice. If these can be achieved, systematic application of EBM principles in a busy hospital department is feasible and worthwhile.
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Kooistra, M. J., L. I. Kooistra, P. van Rijn, and U. Sass-Klaassen. "Woodlands of the past — The excavation of wetland woods at Zwolle-Stadshagen (the Netherlands): Reconstruction of the wetland wood in its environmental context." Netherlands Journal of Geosciences - Geologie en Mijnbouw 85, no. 1 (2006): 37–60. http://dx.doi.org/10.1017/s0016774600021417.

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AbstractInformation on the vegetation and landscape history of a region is often limited, and available data are hard to interprete. A concept is presented here on how a more comprehensive picture of the structure and development of landscapes and vegetations of the past can be gained by integrating the information of several disciplines. Archaeological field methods have been combined with methods used in landscape studies (geology, soil science, micromorphology) and vegetation studies (ecology, palynology and dendrochronology).This concept has been applied and tested during an integrated study of a buried woodland at Zwolle-Stadshagen (Province of Overijssel, the Netherlands). Many large wood remnants were found in a peat layer preserved below a thick clay deposit. The wood remnants were dated by using dendrochronology to the period between ca. 150 BC and AD 580 (ca. 2200 - 1400 cal. BP). Two phases could be distinguished in the development of the peat. The woodland consisted of a closed stand with ash, alder and oak as main species, in the first phase mostly resembling an alder carr, and in the second one the near-extinctFilipendulo-AlnetumPassage et Hofmann 1968. No evidence of exploitation of the woodland by man nor of animal foraging was found.The followed integrated procedure has led to a more substantiated reconstruction of the palaeo-environment with its wetland wood, but also of the influence of human activities on the palaeo-landscape and its woodlands, that could not have been obtained otherwise.
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15

Henn, Volker. "Städte an Zuiderzee und IJssel auf den Hansetagen." Hansische Geschichtsblätter 135 (June 30, 2020): 185–219. http://dx.doi.org/10.21248/hgbll.2017.83.

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This article deals with the representation of the towns along the southern and eastern coasts of the former Zuiderzee and the River IJssel at the Hanseatic Diets between 1367, when Harderwijk, Elburg, and Kampen first attended, and 1507. Out of 102 assemblies in that period the Zuiderzee and IJssel towns’ delegates took part in 57. Unluckily, the extant sources provide little information on the course of the debates and the influence the councillors from the Zuiderzee and IJsseltowns might have exerted on the deliberations. Better documented are the numerous regional Diets which were held in order to prepare for the general gatherings. These regional meetings were convened in order to sound out the opinions of the regional Hanse towns and to decide on practical courses of action. This regional co-operation attained formal recognition when in 1447 a Tohopesate (a military alliance of Hanse towns) was signed, one which created an entirely new Hanseatic Quarter, uniting towns from the eastern Netherlands, the Rhine region and Westphalia, with Deventer and Nimwegen (Nijmegen) as conveners. Since taking part in the Hanseatic Diets and influencing its decisions was predicated on being a member of the Hanse, the exact status of Zwolle and Kampen is a crucial question, since both formally applied for ‘readmission’ to the Hanse in the first half of the 15th century. However, ‘readmission’ is a misleading term, since Zwolle and Kampen had long been part of the Hanse. It would seem that they were interested in a merely formal acknowledgement of their membership, even if their reasons are difficult to fathom. In the case of Kampen trade in Bergen might have been a factor. More importantly, these re-admissions to the Hanse occurred at a time when the towns of Holland were beginning to disengage from the Hanse and emerge as its competitors. This forced the Zuiderzee and IJssel towns to take sides. They managed to remain in favour with the Hanse, without breaking off commercial relations with Holland. This turned out rather well for the Hanse in general and for the towns. Thus, the Zuiderzee- and IJsseltowns functioned as a hinge (Bert Looper) between Holland and the Hanse. Once again, we see that the interplay of regional independence and common solidarity was an essential characteristic of the Hanse.
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Schoenfeldt, M. "HERMAN ROODENBURG. The Eloquence of the Body: Perspectives on Gesture in the Dutch Republic. (Studies in Netherlandish Art and Cultural History, number 6.) Zwolle, Netherlands: Waanders. 2004. Pp. 208. 45.00." American Historical Review 112, no. 5 (2007): 1617–18. http://dx.doi.org/10.1086/ahr.112.5.1617.

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Tanja, Gerard J. "Grensoverschrijdend Milieurecht (Transboundary Environmental Law), J.H. Jans; Zwolle, W.E.J. Tjeenk Willink, 1987, 226 pp. Dr. J.H. Jans is Assistant Professor, University ofGroningen, the Netherlands." Leiden Journal of International Law 1, no. 1 (1988): 101–2. http://dx.doi.org/10.1017/s092215650000073x.

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Hendriks, Steven H., Kornelis J. J. van Hateren, Klaas H. Groenier, et al. "Sex differences in survival of patients with type 2 diabetes in primary care (ZODIAC-50)." BMJ Open 7, no. 10 (2017): e015870. http://dx.doi.org/10.1136/bmjopen-2017-015870.

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ObjectiveTo investigate sex differences in survival of primary care treated patients with type 2 diabetes (T2D) in the Netherlands.SettingPrimary care.ParticipantsA total of 1815 patients who participated in a prospective observational cohort study (Zwolle Outpatient Diabetes Project Integrating Available Care (ZODIAC)) were included of which 56% was female. Inclusion took place in 1998, 1999 and 2001. Vital status was assessed in 2013.Main outcome measureRelative survival of men and women with T2D. The relative survival rate was expressed as the ratio of observed survival of patients divided by the survival of the general population in the Netherlands with comparable age.ResultsAfter 14 years, 888 (49%) patients had died. The relative survival rate was 0.88 (0.81–0.94) for men and 0.82 (0.76–0.87) for women with T2D after 14 years (p value for difference between sexes=0.169). In patients without a history of cardiovascular diseases (CVD), the relative survival was 0.99 (0.94–1.05) in men and 0.92 (0.87–0.97) in women (p value for difference between sexes=0.046).ConclusionsThe survival of men and women with T2D was 12% and 18% lower, respectively, after 14 years of follow-up compared with men and women in the general population. This corresponds to a decrease in median survival of 2.2 and 3.5 years in men and women, respectively. Only for patients with T2D without a history of CVD, a significantly lower relative survival in women compared with men with T2D was found.
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Blouw, Paul Valkema. "Early protestant publications in Antwerp, 1526-30." Quaerendo 26, no. 2 (1996): 94–110. http://dx.doi.org/10.1163/157006996x00070.

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AbstractAt the beginning of her life-long commitment to Dutch post-incunables Miss Kronenberg concentrated on two hitherto unsolved pseudonyms: Adam Anonymus in Basel, the publisher of certain important heterodox works in Dutch, and Hans Luft at Marlborow, the printer of various books for the first Protestant authors in England, including Tyndale. In the work that appeared under these pseudonyms she encountered a number of woodcut initials which originated from the Officina Corveriana in the town of Zwolle in the Northern Netherlands. She thus developed an ingenious theory according to which the true printer was Johannes Hoochstraten, a young man from Antwerp whose father was one of the most eminent publishers in the city. This verdict was generally accepted and, to this day, Miss Kronenberg's analysis is cited without its accuracy ever having been called in doubt. Yet renewed investigation shows that her attributions are unacceptable. It was not Johannes Hoochstraten who printed these clandestine editions but Marten de Keyser (Lempereur) in Antwerp. He collaborated in the production of books in Dutch with the well-known printer-publisher Adriaen van Berghen and, in some publications in English, with his colleague Joannes Grapheus. The part played by De Keyser in the first years of the English reformation thus appears to have been still more important than has hitherto been admitted, while nothing remains of the eminent position which had been accorded to Hoochstraten.
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Hendriks, Steven H., Dennis Schrijnders, Kornelis JJ van Hateren, et al. "Association between body mass index and obesity-related cancer risk in men and women with type 2 diabetes in primary care in the Netherlands: a cohort study (ZODIAC-56)." BMJ Open 8, no. 1 (2018): e018859. http://dx.doi.org/10.1136/bmjopen-2017-018859.

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ObjectiveTo investigate the relationship between body mass index (BMI) and obesity-related cancers in men and women with type 2 diabetes (T2D).DesignObservational cohort study.SettingPrimary care.ParticipantsA total of 52 044 patients with T2D who participated in the ZODIAC (Zwolle Outpatient Diabetes project Integrating Available Care) study between 1998 and 2012 was included (49% women). A dataset of these patients was linked to available information of the Netherlands Cancer Registry to obtain data on cancer incidents.Primary outcome measuresAnalyses were performed for the total group of obesity-related cancers and for non-sex-specific and sex-specific obesity-related cancers (in men: advanced prostate cancer, in women: ovarian, endometrial and postmenopausal breast cancer).ResultsThe median follow-up period in all analyses was 3.1 (1.7–5.0) years in men and 3.1 (1.7–5.1) in women. During follow-up, 689 men and 914 women were diagnosed with an obesity-related cancer. In men, BMI was associated with a higher risk of the total group of obesity-related cancers and non-sex-specific obesity-related cancers (HR (per 5 kg/m2increase) 1.12 (95% CI 1.02 to 1.23) and HR 1.18 (95% CI 1.06 to 1.31)). No association was found with prostate cancer. In women, an association between BMI and all obesity-related cancers combined and sex-specific obesity-related cancers was present (HR 1.15 (95% CI 1.08 to 1.22) and HR 1.22 (95% CI 1.14 to 1.32)). No association with non-sex-specific cancers was found in women.ConclusionsBMI is associated with obesity-related cancers in men with T2D, except with advanced prostate cancer. The results of this study provide reason to reconsider the classification of advanced prostate cancer as an obesity-related cancer, at least in T2D. In women, BMI is associated with the total group of obesity-related cancers and with sex-specific obesity-related cancers.
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Ridder, Monica A. M., Maaike Koning, Tommy L. S. Visscher, Remy A. Hirasing, Jacob C. Seidell, and Carry M. Renders. "Energy Balance–Related Behavior and Anthropometric Measures Among Adolescents Across Three Educational Levels: A Cross-Sectional Study in Dutch Schools." Health Education & Behavior 45, no. 3 (2017): 349–58. http://dx.doi.org/10.1177/1090198117715666.

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Energy balance–related behavior on schooldays and beliefs about school-based interventions may differ between students in different educational levels, sexes, and BMI (body mass index) categories. In Zwolle (the Netherlands), 1,084 adolescents (13-15 years) at 9 secondary schools completed a questionnaire. Overweight prevalence (boys 18.1%, girls 19.3%) increased with decreasing educational level, especially in boys. Girls reported healthier behavior than boys regarding daily consumption of fruit (35% vs. 29%), vegetables (58% vs. 48%), ≤1 snack/candy (36% vs. 26%), ≤3 glasses of sugared drinks (80% vs. 73%; all p < .05). Unhealthier dietary behaviors were associated with lower educational level, except for eating sugary and savory snacks. Snacks and sugared drinks consumed at school were mostly brought from home (61.6% and 68.5%, respectively). Overweight students reported less frequent consumption of daily breakfast, snacks, and sugared drinks than nonoverweight students. Of all students, 40% spent ≥1 hour per day cycling to school. Lower educational level students reported less organized sports activities than higher level students, but more outside play and other activities. Overweight was associated with cycling to school (boys) and participating in organized sports (girls). More girls than boys were interested in lessons about healthy nutrition (44.4% vs. 31.7%). To stimulate physical activity, boys suggested more physical education classes (63%), girls advised more variation (47%) and choice (43%). A healthy school canteen (57%) and offering free fruit (67%) were suggested as promising interventions to stimulate healthy behavior. Educational and environmental interventions to tackle unhealthy dietary and physical activity behavior should be developed in collaboration with parents and tailored to educational level and gender.
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PELEGGI, MAURIZIO. "Indonesia. Representing the Japanese Occupation of Indonesia: Personal Testimonies and Public Images in Indonesia, Japan, and the Netherlands. Edited by REMCO RABEN. Zwolle: Waanders Publishers; and Amsterdam: Netherlands Institute for War Documentation, 1999. Pp. 239. Photographs, Illustrations, Notes." Journal of Southeast Asian Studies 33, no. 3 (2002): 561–94. http://dx.doi.org/10.1017/s0022463402270393.

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Hoetink, Anneloes, Sabine F. Scherphof, Frederik J. Mooi, et al. "An In Vitro Pilot Study Comparing the Novel HemoClear Gravity-Driven Microfiltration Cell Salvage System with the Conventional Centrifugal XTRA™ Autotransfusion Device." Anesthesiology Research and Practice 2020 (September 8, 2020): 1–10. http://dx.doi.org/10.1155/2020/9584186.

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Background. In 2013, the World Health Organization reported a shortage of 17 million red blood cell units, a number that remains growing. Acts to relieve this shortage have primarily focused on allogeneic blood collection. Nevertheless, autologous transfusion can partially alleviate the current pressure and dependence on blood banking systems. To achieve this, current gold standard autotransfusion devices should be complemented with widely available, cost-efficient, and time-efficient devices. The novel HemoClear cell salvage device (HemoClear BV, Zwolle, Netherlands), a gravity-driven microfilter, potentially is widely employable. We evaluated its performance in the cardiac postoperative setting compared to the centrifugal XTRA™ autotransfusion device. Methods. In a split-unit study (n = 18), shed blood collected 18 hours after cardiothoracic surgery was divided into two equal volumes. One-half was processed by the XTRA™ device and the other with the HemoClear blood separation system. In this paired set-up, equal washing volumes were used for both methods. Washing effectivity and cellular recovery were determined by measuring of complete blood count, free hemoglobin, complement C3, complement C4, and D-dimer in both concentrate as filtrate. Also, processing times and volumes were evaluated. Results. The HemoClear and XTRA™ devices showed equal effectiveness in concentrating erythrocytes and leucocytes. Both methods reduced complement C3, complement C4, and D-dimer by ≥90%. The centrifugal device reduced solutes more significantly by up to 99%. Free hemoglobin load was reduced to 12.9% and 15.5% by the XTRA™ and HemoClear, respectively. Conclusion. The HemoClear device effectively produced washed concentrated red blood cells comparably to the conventional centrifugal XTRA™ autotransfusion device. Although the centrifugal XTRA™ device achieved a significantly higher reduction in contaminants, the HemoClear device achieved acceptable blood quality and seems promising in settings where gold standard cell savers are unaffordable or unpractical.
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Flinterman, C. "H. van Maarseveen, D.D. Pessers, M. Gunning, eds., Internationaal Recht en Vrouwen [International Law and Women], Vols. I and II, Tjeenk Willink, Zwolle, the Netherlands 1987, 624 pp., Dfl. 85." Netherlands International Law Review 35, no. 03 (1988): 347. http://dx.doi.org/10.1017/s0165070x00008147.

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Hofmeister, Adolf E. "Bremen, Harderwijk und die Zuiderzee." Hansische Geschichtsblätter 134 (April 18, 2020): 1–18. http://dx.doi.org/10.21248/hgbll.2016.40.

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Bremen, Harderwijk and the ZuiderzeeThe Harderwijk peace treaty of 8 May 1446, negotiated by envoys of the duchy of Burgundy and the Hanse town Bremen and ratified by duke Philip the Good of Burgundy on 8 July 1446, brought to an end a war which had lasted for four years, during which Bremen had waged war on the Burgundian territories of Holland, Zealand, Flanders and Brabant in order to gain compensation for ships and goods which had been captured (mainly by privateers) in the conflict between Holland and the Wendish towns (1438– 41). During the latter conflict, neutral ships were been seized if they were suspected to be carrying Dutch or Flemish goods – a practice which also affected skippers and merchants from Kampen, Harderwijk and Deventer. Therefore Kampen repeatedly took the initiative to midwife an agreement between Bremen and Holland. At first, this failed to produce an acceptable result because Flanders could not be included. In the end, however, the negotiations in Harderwijk in April and May 1446 succeeded in bringing the war to an end. Bremen and Stade obtained financial compensation, to be funded by the towns of Holland and Zealand. Evidence of direct connections between Bremen and the Zuiderzee towns begins in the 14th century and concerns quarrels with citizens of Kampen and Deventer or the naturalization of immigrants from the Zuiderzee towns in Bremen. Beginning in the 12th and 13th centuries, vessels from Holland, Utrecht and Flanders on the one hand and from Bremen and Stade on the other used the shipping route via Vecht, Almere (later Zuiderzee) and Vlie for traffic and trade. From the 13th century, merchants from Bremen and from the Zuiderzee are found side by side in Norway and Scania trading in fish. In the 15th century, merchants of Kampen bought grain in Bremen, whereas merchants of Bremen purchased cloth in Deventer. Furthermore, Kampen, Deventer and Zwolle mediated in Bremen’s quarrels with merchants from Osnabrück and Cologne, with the town of Groningen and especially with Antwerpen. In the 16th century, the political and economic situation of the Zuiderzee towns changed radically, as they were first incorporated into the state of emperor Charles V, and then joined the Republic of the United Netherlands. At the same time, Bremen’s trade shifted to West Friesland and Amsterdam. Thus the intermediary position of the Zuiderzee Hanse towns – poised between Bremen and Holland – came to an end.
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van Berkel, Klaas. "Eric Jorink and Bart Ramakers, eds. Art and Science in the Early Modern Netherlands / Kunst en wetenschap in de vroegmoderne Nederlanden. Nederlands Kunsthistorisch Jaarboek 61. Zwolle: WBOOKS, 2011. 367 pp. €105. ISBN: 978–90–400–7808–8." Renaissance Quarterly 66, no. 3 (2013): 996–97. http://dx.doi.org/10.1086/673618.

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Baas, Pieter. "Houtvademecum 11th edition (Wood Vademecum – in Dutch). R.K.W.M. Klaassen (editor-in-chief), 832 pp., colour illus., 2018. Centrum Hout Almere and Vakbladen.com & Smartwave, Zwolle, The Netherlands. ISBN 978-90-828-172-94. Price: EUR 125.96 (hard cover)." IAWA Journal 39, no. 2 (2018): 246–47. http://dx.doi.org/10.1163/22941932-03902010.

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Brooks, Alasdair. "The Patriot Behind the Pot; A Historical and Archaeological Study of Ceramics, Glassware and Politics in the Dutch Household of the Revolutionary Era: 1780-1815. Stellingwerf, W., 2019. 409 pages, extensively illustrated. Zwolle (Netherlands), Spa-Uitgevers. ISBN 978-90-8932-026 (Pbk)." Post-Medieval Archaeology 54, no. 3 (2020): 389–90. http://dx.doi.org/10.1080/00794236.2020.1812905.

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Reid, William. "The Visser Collection: Arms of the Netherlands in the Collection of H. L. Visser. Volume I: Catalogue of Firearms, Swords and Related Objects. By J P Puype. 290mm. Pt 1: Pp 685; pt 2: Pp 753; pt 3: Pp 735; ills. ISBN 90-400-9881-6. Volume II, Ordnance. By R Roth. 290mm. Pp 248, ills. ISBN 90-400-9882-4. Zwolle: Waanders Publishers, 1996. $80.00 - Dutch Guns in Russia. Edited by M N Larchenko and E Yablonskaya. 290mm. Pp 448, ill. Zwolle: Rijksmuseum Amsterdam and Waanders, 1996. ISBN 90-400-9883-2. $100.00. - Aspects of Dutch Gunmaking: a Collection of Essays. Edited by H L Visser and D W Bailey. 290mm. Pp 752, ills. Zwolle: Waanders, 1997. ISBN 90-400-9884-0. $115.00." Antiquaries Journal 79 (September 1999): 424. http://dx.doi.org/10.1017/s0003581500044875.

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KITLV, Redactie. "Book Reviews." Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia 159, no. 2 (2003): 405–68. http://dx.doi.org/10.1163/22134379-90003749.

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-Leonard Y. Andaya, Michel Jacq-Hergoualc'h, The Malay Peninsula; Crossroads of the maritime silk road (100 BC-1300 AD). [Translated by Victoria Hobson.] Leiden: Brill, 2002, xxxv + 607 pp. [Handbook of oriental studies, 13. -Greg Bankoff, Resil B. Mojares, The war against the Americans; Resistance and collaboration in Cebu 1899-1906. Quezon city: Ateneo de Manila University, 1999, 250 pp. -R.H. Barnes, Andrea Katalin Molnar, Grandchildren of the Ga'e ancestors; Social organization and cosmology among the Hoga Sara of Flores. Leiden: KITLV Press, 2000, xii + 306 pp. [Verhandeling 185.] -Peter Boomgaard, Emmanuel Vigneron, Le territoire et la santé; La transition sanitaire en Polynésie francaise. Paris: CNRS Éditions, 1999, 281 pp. [Espaces et milieux.] -Clara Brakel-Papenhuyzen, Raechelle Rubinstein, Beyond the realm of the senses; The Balinese ritual of kekawin composition. Leiden: KITLV Press, 2000, xv + 293 pp. [Verhandelingen 181.] -Ian Caldwell, O.W. Wolters, History, culture, and region in Southeast Asian perspectives. Ithaca, NY: Southeast Asia program, Cornell University/Singapore: Institute of Southeast Asian studies, 1999, 272 pp. [Studies on Southeast Asia 26.] -Peter van Diermen, Jonathan Rigg, More than the soil; Rural change in Southeast Asia. Harlow, Essex: Prentice Hall / Pearson education, 2001, xv + 184 pp. -Guy Drouot, Martin Stuart-Fox, Historical dictionary of Laos. Second edition. Lanham, Maryland: The Scarecrow Press, 2001, lxi + 527 pp. [Asian/Oceanian historical dictionaries series 35.] [First edition 1992.] -Doris Jedamski, Elsbeth Locher-Scholten, Women and the colonial state; Essays on gender and modernity in the Netherlands Indies 1900-1942. Amsterdam: Amsterdam University Press, 2000, 251 pp. -Carool Kersten, Robert Hampson, Cross-cultural encounters in Joseph Conrad's Malay fiction. Basingstoke: Palgrave, 2000, xi + 248 pp. -Victor T. King, C. Michael Hall ,Tourism in South and Southeast Asia; Issues and cases. Oxford: Butterworth-Heinemann, 2000, xiv + 293 pp., Stephen Page (eds) -John McCarthy, Bernard Sellato, Forest, resources and people in Bulungan; Elements for a history of settlement, trade and social dynamics in Borneo, 1880-2000. Jakarta: Center for international forestry research (CIFOR), 2001, ix + 183 pp. -Naomi M. McPherson, Michael French Smith, Village on the edge; Changing times in Papua New Guinea. Honolulu: University of Hawai'i Press, 2002, xviii + 214 pp. -Gert J. Oostindie, Peter van Wiechen, Vademecum van de Oost- en West-Indische Compagnie Historisch-geografisch overzicht van de Nederlandse aanwezigheid in Afrika, Amerika, Azië en West-Australië vanaf 1602 tot heden. Utrecht: Bestebreurtje, 2002, 381 pp. -Gert J. Oostindie, C.L. Temminck Groll, The Dutch overseas; Architectural Survey; Mutual heritage of four centuries in three continents. (in cooperation with W. van Alphen and with contributions from H.C.A. de Kat, H.C. van Nederveen Meerkerk and L.B. Wevers), Zwolle: Waanders/[Zeist]: Netherlands Department for Conservation, [2002]. 479 pp. -Gert J. Oostindie, M.H. Bartels ,Hollanders uit en thuis; Archeologie, geschiedenis en bouwhistorie gedurende de VOC-tijd in de Oost, de West en thuis; Cultuurhistorie van de Nederlandse expansie. Hilversum: Verloren, 2002, 190 pp. [SCHI-reeks 2.], E.H.P. Cordfunke, H. Sarfatij (eds) -Henk Schulte Nordholt, Tony Day, Fluid iron; State formation in Southeast Asia. Honolulu: University of Hawai'i Press, 2002, xii + 339 pp. -Nick Stanley, Nicholas Thomas ,Double vision; Art histories and colonial histories in the Pacific. Cambridge: Cambridge University Press, 1999, xii + 289 pp., Diane Losche, Jennifer Newell (eds) -Heather Sutherland, David Henley, Jealousy and justice; The indigenous roots of colonial rule in northern Sulawesi. Amsterdam: VU Uitgeverij, 2002, 106 pp. -Gerard Termorshuizen, Piet Hagen, Journalisten in Nederland; Een persgeschiedenis in portretten 1850-2000. Amsterdam: Arbeiderspers, 2002, 600 pp. -Amy E. Wassing, Bart de Prins, Voor keizer en koning; Leonard du Bus de Gisignies 1780-1849; Commissaris-Generaal van Nederlands-Indië. Amsterdam: Balans, 2002, 288 pp. -Robert Wessing, Michaela Appel, Hajatan in Pekayon; Feste bei Heirat und Beschneidung in einem westjavanischen Dorf. München: Verlag des Staatlichen Museums für Völkerkunde, 2001, 160 pp. [Münchner Beiträge zur Völkerkunde, Beiheft I.] -Nicholas J. White, Matthew Jones, Conflict and confrontation in South East Asia, 1961-1965; Britain, the United States, Indonesia and the creation of Malaysia. Cambridge: Cambridge University Press, 2002, xv + 325 pp. -Edwin Wieringa, Peter Riddell, Islam and the Malay-Indonesian world; Transmission and responses. London: Hurst, 2001, xvii + 349 pp. -Edwin Wieringa, Stuart Robson ,Javanese-English dictionary. (With the assistance of Yacinta Kurniasih), Singapore: Periplus, 2002, 821 pp., Singgih Wibisono (eds) -Henk Schulte Nordholt, Edward Aspinall ,Local power and politics in Indonesia; Decentralisation and democracy. Sin gapore: Institute of Southeast Asian studies, 2003, 296 pp. [Indonesia Assessment.], Greg Fealy (eds) -Henke Schulte Nordholt, Coen Holtzappel ,Riding a tiger; Dilemmas of integration and decentralization in Indonesia. Amsterdam: Rozenburg, 2002, 320 pp., Martin Sanders, Milan Titus (eds) -Henk Schulte Nordholt, Minako Sakai, Beyond Jakarta; Regional autonomy and local society in Indonesia. Adelaide: Crawford House, 2002, xvi + 354 pp. -Henk Schulte Nordholt, Damien Kingsbury ,Autonomy and disintegration in Indonesia. London; RoutledgeCurzon, 2003, xiv + 219 pp., Harry Aveling (eds)
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Woziński, Andrzej. "Co wspólnego ma Wniebowzięcie Marii z Ostatnią Wieczerzą, czyli o genezie formy i ikonografii późnośredniowiecznego obrazu ze zbiorów Muzeum Narodowego w Poznaniu,(...)." Porta Aurea, no. 19 (December 22, 2020): 57–76. http://dx.doi.org/10.26881/porta.2020.19.02.

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The late medieval panel painting of the Assumption of Virgin Mary from the Collection of the National Museum in Poznań was most likely created in Greater Poland (Wielkopolska), probably in Poznań, in the early 16th century. Scholars have pointed out the connection of its iconography with several other art pieces from the area of Greater Poland. In the light of these findings, our painting seemed to be traditional in the terms of form, as well as of content. This paper shows that some formal solutions and motifs used in the painting from Poznań differ from a typical iconographic practice, and it has only partial coverage in literary sources. The Apostles’ behaviour not fully corresponding to the subject and the chair in which an unidentified Apostle is sitting in a strangely complicated pose by the sarcophagus are the exceptional traits of the Poznań painting. The reason for their presence is the fact that the painter quoted a large part of the copperplate engraving of the Netherlandish Master IAM of Zwolle on a completely different subject: the Last Supper. The painter repeated selected elements quite accurately, without trying too much to adopt them to the new context. The Poznań painting is one of the countless examples of the use of prints as a pattern in the late medieval workshop practice. But at the same time, it belongs to the smaller in number works that were created in a more sophisticated way, through a compilation of motifs taken from various sources, combined with iconographic transformations. The paintings of Jörg Stoker, active in Ulm, and the prominent Antwerp artist Joos van Cleve analysed in the paper, are the examples of the application of a similar creative procedure. The last part of the text is devoted to the reception of the copperplate engraving by Master IAM of Zwolle, which determined so markedly the form and iconography of the painting at the National Museum in Poznań. The range of impact of this pattern, including Northern France, Greater Poland, Austria, Southern Germany (?), Northern Italy, Sardinia and Castilla, illustrates how universal, despite all the regional differences, the visual culture of Latin Europe was at the time.
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Adams, Ann Jensen. "Martha Hollander. An Entrance for the Eyes: Space and Meaning in Seventeenth-Century Dutch Art. Berkeley and Los Angeles: University of California Press, 2002. xvi + 264 pp. index, illus. bibl. $55. ISBN: 0-520-22135-4. - Mariët Westermann. Art and Home: Dutch Interiors in the Age of Rembrandt. Zwolle, The Netherlands: Waanders Publishers, 2001. 240 pp. illus. bibl. $29.95. ISBN: 0-914738-46-1." Renaissance Quarterly 56, no. 2 (2003): 523–26. http://dx.doi.org/10.2307/1261895.

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Moxey, Keith. "Reindert Leonard Falkenburg. The Land of Unlikeness: Hieronymus Bosch, The Garden of Earthly Delights. Studies in Netherlandish Art and Cultural History 10. Zwolle: WBooks, 2011. 320 pp. €69.95. ISBN: 978–904007767–8." Renaissance Quarterly 65, no. 4 (2012): 1221–22. http://dx.doi.org/10.1086/669382.

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"142. Improvement of Hand Function in Cerebral Palsy C. H. Emmelot, MD, PhD (Zwolle, The Netherlands), P. Houpt, MD (Zwolle, The Netherlands." Neurorehabilitation and Neural Repair 13, no. 1 (1999): 61. http://dx.doi.org/10.1177/1545968399013001119.

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Bihariesingh, Rosita, Rosita Bihariesingh, Pieter Voigt, and Rakesh Bansie. "Use of Accessible Blood Filter for Post-operative Cell Salvage in Cardiac Surgery." International Journal of Surgical Case Reports, September 24, 2021, 1–3. http://dx.doi.org/10.31487/j.ijscr.2021.02.01.

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The availability of centrifugal cell savers supports intraoperative cell salvage and thereby reduces the need for allogeneic red blood cell transfusion. Use of these devices, however, is limited to the operating room, forcing a switch to allogeneic products in the post-operative setting. Here we present a case of massive post-operative bleeding due to severe coagulopathy following CABG. Due to the lack of availability of donor blood products a novel blood filter (HemoClear BV, Zwolle, the Netherlands) was used for post-operative salvage. Because of its accessible use, we believe this salvage device has great clinical value in the poor-resource setting.
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Marchal, Suzanne, Monika Hollander, Marieke Schoenmakers, et al. "Design of the ZWOT-CASE study: an observational study on the effectiveness of an integrated programme for cardiovascular risk management compared to usual care in general practice." BMC Family Practice 20, no. 1 (2019). http://dx.doi.org/10.1186/s12875-019-1039-z.

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Abstract Background Cardiovascular diseases (CVD) contribute considerably to mortality and morbidity. Prevention of CVD by lifestyle change and medication is important and needs full attention. In the Netherlands an integrated programme for cardiovascular risk management (CVRM), based on the Chronic Care Model (CCM), has been introduced in primary care in many regions in recent years, but its effects are unknown. In the ZWOT-CASE study we will assess the effect of integrated care for CVRM in the region of Zwolle on two major cardiovascular risk factors: systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-cholesterol) in patients with or at high risk of CVD. Methods This study is a pragmatic observational study comparing integrated care for CVRM with usual care among patients aged 40–80 years with CVD (n = 370) or with a high CVD risk (n = 370) within 26 general practices. After 1 yr follow-up, primary outcomes (SBP and LDL-cholesterol level) are measured. Secondary outcomes include lifestyle habits (smoking, dietary habits, alcohol use, physical activity), risk factor awareness, 10-year risk of cardiovascular morbidity or mortality, health care consumption, patient satisfaction and quality of life. Conclusion The ZWOT-CASE study will provide insight in the effects of integrated care for CVRM in general practice in patients with CVD or at high CVD risk. Trial registration The ZWOlle Transmural Integrated Care for CArdiovaScular Risk Management Study; ClinicalTrials.gov; Identifier: NCT03428061; date of registration: 09-02-2018; This study has been retrospectively registered.
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Henderickx, Jannie G. E., Romy D. Zwittink, Ingrid B. Renes, et al. "Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-92222-y.

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AbstractFunctionality of the gastrointestinal tract is essential for growth and development of newborns. Preterm infants have an immature gastrointestinal tract, which is a major challenge in neonatal care. This study aims to improve the understanding of gastrointestinal functionality and maturation during the early life of preterm infants by means of gastrointestinal enzyme activity assays and metaproteomics. In this single-center, observational study, preterm infants born between 24 and 33 weeks (n = 40) and term infants born between 37 and 42 weeks (n = 3), who were admitted to Isala (Zwolle, the Netherlands), were studied. Enzyme activity analyses identified active proteases in gastric aspirates of preterm infants. Metaproteomics revealed human milk, digestive and immunological proteins in gastric aspirates of preterm infants and feces of preterm and term infants. The fecal proteome of preterm infants was deprived of gastrointestinal barrier-related proteins during the first six postnatal weeks compared to term infants. In preterm infants, bacterial oxidative stress proteins were increased compared to term infants and higher birth weight correlated to higher relative abundance of bifidobacterial proteins in postnatal week 3 to 6. Our findings indicate that gastrointestinal and beneficial microbial proteins involved in gastrointestinal maturity are associated with gestational and postnatal age.
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Couvrat Desvergnes, Amélie, Leila Sauvage, Jan de Hond, Paolo D’Imporzano, and Matthias Alfeld. "Dutch or Iranian? Technical study of a seventeenth-century painting on paper from Gesina Ter Bosch’s scrapbook." Heritage Science 9, no. 1 (2021). http://dx.doi.org/10.1186/s40494-021-00577-2.

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AbstractA scrapbook compiled between 1660 and 1687 by Gesina ter Borch (1631–1690), a female artist from the small town of Zwolle in the Netherlands, contains an intriguing painting on paper of a full-length portrait of a young Iranian. Although the figure wears the attributes in vogue at the Safavid court of Isfahan, certain elements seem rather incongruous and peculiar. The general composition appears static and rigid, an impression reinforced by an unusual black painted background. Stylistic differences within the painting were also observed, hinting at alterations to the original painting. To investigate the history of the painting and to reconstruct the original composition and identify the later additions, perhaps made by Gesina herself, the painting was examined with different imaging and analytic techniques available at the Conservation and Science Department of the Rijksmuseum. This allowed the research team to discriminate between pigments used for the original composition and pigments used to conceal damaged areas of the painting and added pictorial elements. After interpreting scientific results, as well as historical findings, it was possible to shed light on the use of specific pigments, namely lead white and smalt, and on the possible misinterpretation of some details, such as the cup held by the young man. The results of macro X-ray fluorescence scanning (MA-XRF) and lead isotope analysis, viewed in the light of information about the economic and cultural exchanges between Iran and the Netherlands in the seventeenth century, fed new theories about the origin and history of this painting. The painting, originally made in Iran in the style of Riza Abbasi, the head of the Emperor Shah Abbas’ library, ended up in Gesina ter Borch's workshop and may have been ‘restored’ by the artist to improve its condition and to match her tastes.
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Bonvanie, Irma J., Anouk AH Weghorst, Gea A. Holtman, et al. "Oral ondansetron for paediatric gastroenteritis in primary care: a randomised controlled trial." British Journal of General Practice, June 25, 2021, BJGP.2021.0211. http://dx.doi.org/10.3399/bjgp.2021.0211.

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BackgroundAcute gastroenteritis (AGE) affects almost all children aged ≤5 years. In secondary care, ondansetron was found to be effective at reducing vomiting.AimTo determine the effectiveness of adding oral ondansetron to care as usual (CAU) to treat vomiting in children with AGE attending out-ofhours primary care (OOH-PC).Design and settingA pragmatic randomised controlled trial at three OOH-PC centres in the north of the Netherlands (Groningen, Zwolle, and Assen), with a follow-up of 7 days.MethodChildren were included if they were: aged 6 months–6 years; AGE diagnosed by a GP; ≥4 reported episodes of vomiting in the 24 hours before presentation; ≥1 reported episode of vomiting in the 4 hours before presentation; and written informed consent from both parents. Children were randomly allocated to either the control group or the intervention group. The control group received CAU, namely oral rehydration therapy. The intervention group received CAU plus one dose of oral ondansetron (0.1 mg/kg).ResultsIn total, 194 children were included for randomisation. One dose of oral ondansetron decreased the proportion of children who continued vomiting within 4 hours from 42.9% to 19.5%, with an odds ratio of 0.37 (95% confidence interval [CI] = 0.20 to 0.72, number needed to treat: four). Ondansetron also decreased the number of vomiting episodes within 4 hours (incidence rate ratio 0.51 [95% CI = 0.29 to 0.88]) and improved overall parental satisfaction with treatment (P = 0.027).ConclusionChildren with AGE and increased risk of dehydration due to vomiting could be treated with ondansetron in primary care to stop vomiting more quickly and increase parental satisfaction with treatment. These results could be used to improve the quality and efficacy of general practice medicine.
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Haak, Svenja L., Iris JE Renken, L. Cara Jager, Heleen Lameijer, and Brigitta (Britt) YM van der Kolk. "Diagnostic accuracy of point-of-care lung ultrasound in COVID-19." Emergency Medicine Journal, November 18, 2020, emermed-2020-210125. http://dx.doi.org/10.1136/emermed-2020-210125.

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BackgroundA promising modality for diagnosing pulmonary manifestations of COVID-19 in the emergency department (ED) is point-of-care ultrasound (POCUS) of the lungs. The currently used PCR as well as chest X-ray and CT scanning have important disadvantages. The aim of this study is to evaluate the diagnostic accuracy of POCUS in patients with suspected pulmonary manifestations of COVID-19 in the ED.MethodsThis prospective diagnostic accuracy study was conducted at the ED of our non-academic level 1 trauma centre (Isala, Zwolle, the Netherlands). Patients were enrolled between 14 April and 22 April 2020. Patients (aged ≥16 years) with suspected COVID-19 presenting to the ED underwent POCUS. All patients received current standard of care, including PCR (naso-oropharyngeal swab). Outcome of POCUS was compared with PCR or CT scan outcome to determine diagnostic accuracy. Diagnostic accuracy measures were calculated using 2×2 contingency tables.Results100 patients were eligible to participate in this study, data of 93 patients were analysed. 27 (29%) patients were found positive for COVID-19 by PCR or CT. POCUS had a sensitivity of 89% (95% CI 70% to 97%), specificity of 59% (95% CI 46% to 71%), negative predictive value of 93% (95% CI 79% to 98%) and positive predictive value of 47% (95% CI 33% to 61%). In a subgroup of patients without previous cardiopulmonary disease (n=37), POCUS had a sensitivity of 100% (95% CI 70% to 100%), specificity of 76% (95% CI 54% to 90%), negative predictive value of 100% (95% CI 79% to 100%) and positive predictive value of 67% (95% CI 41% to 86%).ConclusionPOCUS of the lungs could serve as a valuable, radiation-free tool for excluding pulmonary manifestations of COVID-19 in patients in the ED at the point of assessment, especially in patients without previous cardiopulmonary disease.Trial registrationDutch Trial Register, No: NTR8544.
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Weghorst, Anouk AH, Gea A. Holtman, Irma J. Bonvanie, et al. "Cost-effectiveness of oral ondansetron for children with acute gastroenteritis in primary care: a randomised controlled trial." British Journal of General Practice, May 17, 2021, BJGP.2020.1093. http://dx.doi.org/10.3399/bjgp.2020.1093.

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BackgroundAcute gastroenteritis is a common childhood condition with substantial medical and indirect costs, mostly because of referral, hospitalisation, and parental absence from work.AimTo determine the cost-effectiveness of adding oral ondansetron to care as usual (CAU) for children with acute gastroenteritis presenting to out-of-hours primary care (OOH-PC).Design and settingA pragmatic randomised controlled trial from December 2015 to January 2018, at three OOHPC centres in the north of the Netherlands (Groningen, Zwolle, and Assen) with a follow-up of 7 days.MethodChildren were recruited at the OOH-PC and parents kept a parental diary. Inclusion criteria were: aged 6 months–6 years; diagnosis of acute gastroenteritis; at least four reported episodes of vomiting 24 hours before presentation, at least one of which was in the 4 hours before presentation; and written informed consent from both parents. Children were randomly allocated at a 1:1 ratio to either CAU (oral rehydration therapy) or CAU plus one dose of 0.1 mg/kg oral ondansetron.ResultsIn total, 194 children were included for randomisation. One dose of oral ondansetron decreased the proportion of children who continued vomiting within the first 4 hours from 42.9% to 19.5%, (a decrease of 54.5%), with an odds ratio of 0.4 (95% confidence interval [CI] = 0.2 to 0.7; number needed to treat: four). Total mean costs in the ondansetron group were 31.2% lower (€488 [£420] versus €709 [£610]), and the total incremental mean costs for an additional child free of vomiting in the first 4 hours was −€9 (£8) (95% CI = −€41 [£35] to €3 [£3]).ConclusionA single oral dose of ondansetron for children with acute gastroenteritis, given in OOH-PC settings, is both clinically beneficial and cost-effective.
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"Jan Willem Buisman. Tussen vroomheid en Verlichting: Een cultuurhistorisch ensociologisch onderzoek naar enkele aspecten van de Verlichting in Nederland (1755–1810) In two volumes. Zwolle, Netherlands: Waanders. 1992. Pp. 265; 269–507. $65.00." American Historical Review, December 1994. http://dx.doi.org/10.1086/ahr/99.5.1708.

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"38. Effects of Loading of the Lower Hemiparetic Extremity on Walking Speed in Stroke Patients Boudewijn J. Kollen, PT, Marc B. Reitberg, Msc, Gert Kwakkel, PhD, and Cees H. Emmelot, PhD (Zwolle, The Netherlands." Neurorehabilitation and Neural Repair 13, no. 1 (1999): 30. http://dx.doi.org/10.1177/154596839901300128.

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