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Добірка наукової літератури з теми "159. 974: 37 (043.2)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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Статті в журналах з теми "159. 974: 37 (043.2)"

Wiseman, Gregory A., Leo I. Gordon, Pratik S. Multani, et al. "Ibritumomab tiuxetan radioimmunotherapy for patients with relapsed or refractory non-Hodgkin lymphoma and mild thrombocytopenia: a phase II multicenter trial." Blood 99, no. 12 (2002): 4336–42. http://dx.doi.org/10.1182/blood.v99.12.4336.

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Mildly thrombocytopenic patients with relapsed or refractory low-grade non-Hodgkin lymphoma (NHL) have an increased risk of chemotherapy-induced myelosuppression following treatment. The safety and efficacy of radioimmunotherapy with a reduced dose of90Y ibritumomab tiuxetan (0.3 mCi/kg [11 MBq/kg]; maximum 32 mCi [1.2 GBq]) was evaluated in 30 patients with mild thrombocytopenia (100-149 × 109 platelets/L) who had advanced, relapsed or refractory, low-grade, follicular, or transformed B-cell NHL. The ibritumomab tiuxetan regimen included an infusion of rituximab (250 mg/m2) and injection of 1

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Pedroza, Albert, Zack Fleishhacker, Colette Galet, and Lucy Wibbenmeyer. "37 Procedural Pain Management in Burn Patients (Phase II) - A Quality Improvement Project." Journal of Burn Care & Research 43, Supplement_1 (2022): S25—S26. http://dx.doi.org/10.1093/jbcr/irac012.040.

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Abstract Introduction This quality improvement project (QI) focused on reducing procedural pain. Phase I of this project demonstrated a need to improve our patients' and nurses’ satisfaction with pain control management during hydrotherapy. In this phase (Phase II), we educated the nursing staff on 1) appropriate dosing and timing of opioid administration (Oral and IV) and 2) need for more frequent midazolam administration before hydrotherapy. We also assessed the safety and potential benefits of ketamine for procedural pain control. Methods Patients undergoing wound cleaning procedures were s

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Hernández-Cruz, B., M. J. Miranda García, J. Barrera, et al. "AB1030 PATIENT CARE AT THE FRACTURE LIAISON SERVICE REDUCE THE GAP IN THE TREATMENT OF OSTEOPOROSIS BETWEEN MEN AND WOMEN." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1638–39. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4150.

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BackgroundOsteoporosis (OP) between men and women is different,and the way it is treated also differs. In men, the gap in clinical care, especially diagnosis and treatment, is worse.ObjectivesTo analyze the differences in the clinical characteristics of OP (demographics, comorbidities, diagnosis, and treatment) in an gold star Fracture Liaison Service (FLS).MethodsDesign: Observational, prospective, analytical study of usual clinical practice. All patients treated from an FLS from May 2018 to August 2021 were prospectively included. Of each patient, 160 clinical variables were introduced in a

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Abdul Rahman, Rozana, Neethu Billy Graham Mariam, Hitesh Mistry, et al. "Differential response rates in early-phase cancer clinical trials (EPCCT)." Journal of Clinical Oncology 39, no. 15_suppl (2021): 3133. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3133.

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3133 Background: The primary objective of EPCCT (phase I and non-randomised phase II trials) is to determine the safety and tolerability of new therapeutic agents. Response rates (RR) in these trials have typically been reported at around 10-15%. Increasingly RR and survival outcomes are now investigated in EPCCT as primary or secondary objectives. Methods: Retrospective data analysis was performed on patients (pts) enrolled onto an EPCCT between January 2018 and December 2019 at The Christie NHS Foundation Trust, UK. Data on demographics, prior systemic treatment, sites of disease, performanc

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Sasaki, Koji, Ildefonso Ismael Rodriguez-Rivera, Hagop M. Kantarjian, et al. "Correlation of Lymphocyte Count with Treatment Response to Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase." Blood 124, no. 21 (2014): 4538. http://dx.doi.org/10.1182/blood.v124.21.4538.4538.

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Abstract Background: Total lymphocyte count (TLC) has been shown to correlate with outcomes in patients (pts) with acute leukemia. The clinical correlation to TLC in pts with chronic myeloid leukemia in chronic phase (CML-CP) who were treated with a tyrosine-kinase inhibitor (TKI) is unclear. Methods: Lymphocyte data in pts with newly diagnosed CML-CP who were enrolled in consecutive or parallel clinical trials with front-line imatinib (IM), nilotinib (Nilo), or dasatinib (Dasa) were collected at the time of diagnosis, and 3 and 6 months (M) after the start of TKI. Relative lymphocytrosis (RLC

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Hajji, K. Tawfiki, F. Lépine, J. G. Bisaillon, and R. Beaudet. "Simultaneous removal of phenol, ortho- and para-cresol by mixed anaerobic consortia." Canadian Journal of Microbiology 45, no. 4 (1999): 318–25. http://dx.doi.org/10.1139/w99-003.

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Two different anerobic consortia, one removing phenol and ortho- (o-) cresol and the other removing para- (p-) cresol, were cultivated in serum bottles using whey as cosubstrate substitute for proteose peptone. Phenol and p-cresol removal with the phenol-removing consortium were the same with 0.0125% (w/v) whey as with 0.05% proteose peptone. For the other consortium, 8 days were required to decrease the p-cresol concentration from 35 to 2 mg/L with 0.025% whey, while 35 days were required to achieve a similar removal with 0.5% proteose peptone. The two consortia were mixed and cultivated with

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Dallemagne, M., E. Ghys, D. De Troy, and I. Donnay. "259 DOES THE SENSITIVITY TO OXIDATIVE STRESS DEPEND ON THE SEX OF THE EMBRYO?" Reproduction, Fertility and Development 27, no. 1 (2015): 219. http://dx.doi.org/10.1071/rdv27n1ab259.

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Male and female bovine embryos show several differences as early as the blastocyst stage. For example, differences are observed in metabolism, developmental kinetics, or gene expression that can lead to a shift in the sex ratio. Interestingly, the culture medium differentially affects male and female embryos. We previously showed that male Day 7 blastocysts present lower apoptotic rates than females (Ghys et al. 2013 Reprod. Fertil. Dev. 25, 194). The objective of the present study was to determine if such difference might be related to a differential sensitivity to oxidative stress, known to

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Sawattep, Jeeranut, Thad A. Howard, Noppawan P. Morales, et al. "Single Nucleotide Polymorphism (SNP) Discovery within the UGT1A Gene Complex: Allelic Frequencies and Ethnic Differences." Blood 104, no. 11 (2004): 3780. http://dx.doi.org/10.1182/blood.v104.11.3780.3780.

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Abstract The UDP-glycosyltransferase (UGT1A) gene complex plays an important role in the hepatic metabolism of many chemicals, toxins, and drugs including bilirubin and acetaminophen. In this large gene complex that spans over 200kb, there are at least 13 different coding regions that can serve as exon 1, followed by a common sequence that contains exons 2–5. These variable exon 1 sequences confer different chemical specificities for binding compounds, while exons 2–5 provide glycosyltransferase function (glucuronidation) that enhances water solubility and excretion. Mutations and polymorphism

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Polizzotto, Mark N., Irini Sereti, Thomas S. Uldrick, et al. "Pomalidomide Induces Expansion of Activated and Central Memory CD4+ and CD8+ T Cells in Vivo in Patients with and without HIV Infection." Blood 124, no. 21 (2014): 4128. http://dx.doi.org/10.1182/blood.v124.21.4128.4128.

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Abstract Background: Despite antiretroviral therapy (ART), people with HIV continue to exhibit immune deficits including failure to fully reconstitute CD4 T cell numbers and function, resulting in increased risks of tumors and infections and reduced response to vaccination. Pomalidomide, a derivative of thalidomide (IMID), has immunomodulatory properties that may be beneficial in this setting. We explored its impact on lymphocyte number and activation in patients with and without HIV treated within a prospective clinical trial for Kaposi sarcoma. Methods: Patients received pomalidomide 5mg ora

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Тези доповідей конференцій з теми "159. 974: 37 (043.2)"

Гражданкина, Д. В., И. А. Бондарь та А. а. Демин. "МЕТАБОЛИЧЕСКИЕ ФАКТОРЫ, ВЗАИМОСВЯЗАННЫЕ С ОТДАЛЕННЫМИ НЕБЛАГОПРИЯТНЫМИ СЕРДЕЧНО-СОСУДИСТЫМИ СОБЫТИЯМИ ПРИ САХАРНОМ ДИАБЕТЕ 2 ТИПА". У X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-67.

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ЦЕЛЬ: оценить значение метаболических параметров, ассоциированных с развитием отдаленных не- благоприятных сердечно-сосудистых событий (НССС) у больных сахарным диабетом 2 типа (СД2). МАТЕРИАЛЫ И МЕТОДЫ: обследовано 94 больных СД2 (средний возраст 55,3±5,5 лет; 65% женщин). У всех больных СД2 была гипертоническая болезнь, избыток массы тела или ожирение, у 37 пациентов (39,4%) - стабильная ишемическая болезнь сердца. Критерии исключения: наличие клинически выра- женной хронической сердечной недостаточности (ХСН), фракции выброса левого желудочка <50%, хро-&#x0D

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