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Добірка наукової літератури з теми "623.452 6"

Автор: Grafiati

Опубліковано: 11 травня 2022

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Статті в журналах з теми "623.452 6":

Fesenmeier, Ludwig. "Paul Videsott. Padania scrittologica. Analisi scrittologiche e scrittometriche di testi in italiano settentrionale antico dalle origini al 1525." Linguistica 51, no. 1 (December 31, 2011): 385–89. http://dx.doi.org/10.4312/linguistica.51.1.385-389.

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Il presente volume, versione rimaneggiata e tradotta della Habilitationsschrift dell’autore,1 mira a “delineare l’evoluzione della lingua scritta volgare non letteraria dell’Italia settentrionale” (7), adoperando un metodo sviluppato, e variamente applica- to, soprattutto da Hans Goebl. L’opera si divide in quattro capitoli, preceduti da due prefazioni (1-6)2 e seguiti dalla “Bibliografia” (423-454), dalle “Cartine coropletiche” (455-620), e da due indici (621-624).

Tsay, J. G., R. S. Chen, W. L. Wang, and B. C. Weng. "First Report of Anthracnose on Cucurbitaceous Crops Caused by Glomerella magna in Taiwan." Plant Disease 94, no. 6 (June 2010): 787. http://dx.doi.org/10.1094/pdis-94-6-0787a.

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During the summer and fall of 2006, leaf anthracnose samples were collected from fields of cucumber (Cucumis sativus L.), calabash gourd (Lagenaria siceraria (Molina) Standley), and luffa (Luffa cylindrica (L.) M. Roem.) in southern Taiwan. On cucumber leaves, spots start as water-soaked areas and expand into brown spots. Leaf lesions on calabash gourd and luffa begin as water soaked and then become light brown-to-reddish spots. Centers of lesions sometimes fall out; giving infected leaves a shot-hole appearance. Small pieces (approximately 2 × 2 mm) of diseased leaf tissue from margins of individual lesions were surface disinfected in 1% sodium hypochlorite solution for 1 min, rinsed in sterile water, plated on water agar, and incubated at 25°C. After 4 days, mycelium was isolated, transferred to potato dextrose agar (PDA), and then incubated at 25°C in a 12-h light/darkness regimen. Fast-growing colonies on PDA were white to orange or pink with abundant acervuli but no perithecium. One-celled conidia were ovoid to oblong and 12 to 20 × 4 to 6 (15.9 × 5.0) μm. The morphological traits were identical to those of Colletotrichum magna (teleomorph Glomerella magna Jenkins & Winstead) and clearly distinct from those of C. orbiculare (Berk. & Mont.) Arx (synonym C. lagenarium (Pass.) Ellis & Halst. (conidia were mostly oblong, measuring 7 to 11 × 2 to 6 [9.3 × 4.2] μm, with slow-growing gray colonies) (2,3). Koch's postulates were performed to verify that the isolates were capable of causing anthracnose on cucurbitaceous crops. Pathogenicity tests were conducted in the greenhouse at 25°C under natural daylight conditions. Isolate C0604 was grown on PDA for 14 days and a spore suspension was made (106 spores/ml). Three 14-day-old seedlings at the two- to three-leaf stage of muskmelon (Cucumis melo L. var. reticulatus Naud., cv. Sapphire), squash (Cucurbita moschata Duch., cv. Achen), calabash gourd (cv. Huapu), and luffa (cv. 623) were sprayed with the spore suspension and then covered with plastic bags. Control treatments were sprayed with sterile water. After 2 days, the bags were removed. Typical anthracnose symptoms developed on all inoculated seedlings 7 days after inoculation. G. magna was reisolated from inoculated leaves following the protocol used for the original isolation. Control seedlings developed no symptoms. To confirm the identity of the fungus, PCR amplification and DNA sequencing of the internal transcribed spacer 1 (ITS1)-5.8S-ITS2 of rRNA gene of the isolate C0604 was performed by using ITS1/ITS4 as the PCR and sequencing primers. Sequence analysis of the 558-bp PCR product (GenBank Accession No. GU358453) showed 100% identity to the rRNA sequence of G. magna (GenBank Accession No. DQ003103) (1). PCR amplification of the ITS region was also carried out using species-specific primer GmF (5′- GTG AAC ATA CCT CAA ACG TTG CC -3′)/GmR (5′- GGA GGG TCC GCC ACT GTA TTT CG -3′) designed in this study. A DNA fragment of approximately 378 bp was amplified from nine isolates of G. magna, whereas no amplification products were obtained from reference cultures of C. gloeosporioides (Penz.) Penz. & Sacc. and C. orbiculare. To our knowledge, this is the first report of G. magna causing anthracnose on cucurbitaceous crops in Taiwan. References: (1) M. Du et al. Mycologia 97:641, 2005. (2) S. F. Jenkins, Jr. and N. N. Winstead. Phytopathology 54:452, 1964. (3) T. A. Zitter et al., eds. Compendium of Cucurbit Diseases. The American Phytopathological Society, St. Paul, MN, 1996.

Садовников, С. И., та А. И. Гусев. "Влияние температуры на размер частиц и рекристаллизацию нанопорошков сульфида серебра". Физика твердого тела 60, № 7 (2018): 1303. http://dx.doi.org/10.21883/ftt.2018.07.46113.341.

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AbstractThe recrystallization of silver sulfide Ag_2S nanoparticles has been studied and the range of the thermal stability of the nanoparticle sizes has been determined. Nanopowders Ag_2S with particle sizes of 45–50 nm were obtained by chemical deposition from aqueous solutions. To study the thermal stability of the Ag_2S nanoparticle sizes, the nanocrystalline powders have been annealed in a vacuum of 0.01 Pa on heating from room temperature to 493 K and in argon at 623 K. Annealing up to a temperature of 453 K leads to insignificant nanoparticle growth and annealing of microstrains, which allows one to consider this temperature range as the region of thermal stability of the silver sulfide nanostate. The temperature range from 450 to 900 K, in which the particle size increases by a factor of 3–6, corresponds to the temperature of collective recrystallization of the silver sulfide nanopowder.

Serge, Gagnon André Yelle. "622 PB 442 THERMAL WEED CONTOL FOR VEGETABLE PRODUCTION." HortScience 29, no. 5 (May 1994): 521d—521. http://dx.doi.org/10.21273/hortsci.29.5.521d.

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In the summer of 1992, a 4-year research program on the utilisation of propane in agriculture was initiated between ICG Propane and Lava1 University. Experiments were conducted to evaluate the effects of propane burners on weed control as a pre-establishment treatment. The data indicate that the efficiency of weed control is related to tractor speed and gas pressure. When weed height is between 1 and 2 centimetres, most of the heat treatments were as effective as those with the herbicide paraquat. The best and most economical heat treatment was at a tractor speed of 6 Km-hr and a gas pressure of 65 PSI. With larger weeds, efficiency increased with reduces tractor speed and increased gas pressure. In addition, high intensity treatments provided excellent control on broadleaf weeds but were less efficient on grass species. A preliminary economical evaluation showed that propane burners are competitive with chemical herbicides and large-scale commercial trials are planned for summer 1994.

Clark, Stephen, Michael Sidlak, Amy Mathers, Melinda Poulter, and James Platts-Mills. "Clinical Yield of Routine Use of Molecular Testing for Adult Outpatients with Diarrhea." Open Forum Infectious Diseases 4, suppl_1 (2017): S33. http://dx.doi.org/10.1093/ofid/ofx162.080.

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Abstract Background Molecular diagnostics for enteropathogens increase yield while reducing turnaround time. However, many pathogens do not require specific therapy, and the cost is substantial. Methods We reviewed the use of the FilmArray GI Panel (BioFire Diagnostics, Salt Lake City, Utah) in adult outpatients at the University of Virginia and identified clinical features that could limit testing without reducing yield. We defined yield as (a) detection of a pathogen, (b) detection of a pathogen for which antimicrobial therapy is indicated, or (c) detection of a pathogen that can change management, which additionally included viral pathogens in immunocompromised patients. Results Between March 23, 2015 and February 25, 2016, we reviewed 452 tests from adult outpatients with diarrhea. A pathogen was detected in 88/452 (19.5%). The most common pathogens were: enteropathogenic E. coli (36; 8.0%), norovirus (17; 3.8%), Campylobacter (7, 1.5%), enteroaggregative E. coli (6, 1.3%), Giardia (6; 1.3%), and sapovirus (5; 1.1%). Based on clinical guidelines, antimicrobial treatment was clearly indicated for 19/452 subjects (4.2%). Limiting testing to patients with an additional enteric symptom (abdominal pain, nausea, vomiting, fecal urgency, tenesmus, or flatulence), a travel history, or an immunocompromising condition would reduce testing by 25.9%, with a treatable pathogen identified in 18/331 (5.4%) (sensitivity 94.7%, specificity 27.7%). Further modifying testing criteria to exclude subjects with vomiting, 18/288 (6.3%) had a treatable pathogen (sensitivity 94.7%, specificity 37.3%), and a pathogen which could change management was detected in 28/288 (9.7%) (sensitivity 96.6%, specificity 38.5%). Excluding immunocompromised subjects or those with a travel history, American College of Gastroenterology guidelines for testing were met by 293/348 (84.2%) with a documented duration of diarrhea, and a treatable pathogen was detected in 8/293 (2.7%) vs. 3/55 (5.5%) who did not meet testing guidelines. Conclusion Testing could be reduced by 36.3% without decreasing clinical yield by limiting testing to patients with diarrhea with an additional enteric symptom and no history of vomiting, a travel history, or an immunocompromising condition. ACG guidelines did not improve testing efficiency. Disclosures All authors: No reported disclosures.

Morgan, Gareth J., Faith E. Davies, Walter M. Gregory, Sue E. Bell, Alex J. Szubert, Nuria Navarro-Coy, Mark T. Drayson, et al. "Thalidomide Maintenance Significantly Improves Progression-Free Survival (PFS) and Overall Survival (OS) of Myeloma Patients When Effective Relapse Treatments Are Used: MRC Myeloma IX Results." Blood 116, no. 21 (November 19, 2010): 623. http://dx.doi.org/10.1182/blood.v116.21.623.623.

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Abstract Abstract 623 Background: Although a meta-analysis has suggested that a consistent PFS benefit is seen with maintenance thalidomide therapy in multiple myeloma (MM) patients, the impact on OS remains unclear (Hicks LK, et al. Cancer Treat Rev 2008;34:442-452). This could be due to a lack of effect, differing biological subgroups in relatively small studies with short follow-up, or lack of effective relapse treatment. Aims: The study was set up to evaluate the effect of thalidomide maintenance therapy in newly diagnosed MM patients aged ≥ 18 years with OS and PFS as end points, and to examine differential effects in fluorescence in situ hybridization (FISH) identified molecular subgroups. Methods: Following induction treatment in an intensive pathway for younger fitter patients and a non-intensive pathway for the remaining patients, eligible patients were randomized to open-label thalidomide maintenance until progression (50 mg/day escalating to 100 mg/day after 4 weeks assuming good tolerance) or no maintenance. Patients of all ages were included in the randomization. FISH was performed using standard approaches. Adverse FISH groups were defined as any of t(4;14), t(14;16), t(14;20), 1q+, 17p−, or 1p32− (in the intensive pathway only); the remainder were defined as favorable. Results: Overall, 820 patients were eligible of which 818 were evaluable. Median patient age was 65 years (range, 31−89). Median follow-up from maintenance was 38 months (range 12−66 months). Median time on maintenance was 7 months (range 0−50 months). Maintenance thalidomide significantly improved PFS, with a difference between the curves of 13% (95% confidence interval [CI] 6%−20%) established by 24 months and maintained till the current maximum follow-up at 66 months (hazard ration [HR] 1.36; 95% CI 1.15−1.61; logrank P < 0.001). However, in the initial analysis there was no apparent impact on OS (P = 0.40). These findings were consistent regardless of prior intensive or non-intensive induction treatment. At 66 months follow-up, a PFS benefit was seen in the favorable FISH group (P = 0.004) with no effect on OS (P = 0.6). In the adverse FISH group there was no effect on PFS (P = 0.48) and a negative effect on OS (P = 0.009). Subsequently, we evaluated the effect of relapse treatment on outcomes and used this data in a mathematical model to determine if OS benefit would have accrued from the prolonged PFS if all patients had received effective treatment at relapse. A total of 523 patients have progressed to date and of these, 47% received thalidomide as initial relapse treatment (either as a single agent or in combination), 30% received novel agents (either bortezomib or lenalidomide), and 27% received alkylating agents or steroids. Median survival after progression was significantly worse in patients who received thalidomide maintenance than those who did not (P < 0.005); this could, at least partly, be attributed to patients who received thalidomide at progression. In those patients, the median OS after progression was significantly greater in the no maintenance group versus the thalidomide maintenance group (P = 0.004). Among patients treated with novel agents at progression, prior thalidomide maintenance therapy had no impact on OS and these patients were effectively salvaged. The mathematical model employed to examine the effect of effective salvage therapy at progression suggested that a significant survival benefit of 5.5% at 3-years in favor of thalidomide maintenance would have accrued if all patients had received effective therapy at progression (HR 0.77; 95% CI 0.60–0.99; P = 0.04). Next, we examined whether continuous thalidomide therapy was associated with a consolidation or maintenance effect. Upgrading of response with thalidomide maintenance was not common. Importantly, there was no difference in response over time between maintenance therapy and no maintenance. In contrast to what has been reported previously, these findings suggest a maintenance effect. Conclusions: Maintenance thalidomide significantly improves PFS and if effective relapse treatment is available this translates into an OS advantage. The median duration of maintenance thalidomide therapy of 7 months in the present study was short. The clinical impact of maintenance would be improved if patients could remain on therapy for longer, suggesting that the use of other agents such as lenalidomide, with better tolerability profiles, may produce better results. Disclosures: Off Label Use: THALOMID (thalidomide) in combination with dexamethasone is indicated for the treatment of patients with newly diagnosed multiple myeloma. Davies:Celgene: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Ortho Biotech: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Novartis: Membership on an entity's Board of Directors or advisory committees.

Cooke, A. S. "Book Review: Organotin, edited by M.A. Champ and P.F. Seligman, Chapman and Hall, London, 1996. 623 pp. Price: £195. ISBN 0 412 58240 6." Aquatic Conservation: Marine and Freshwater Ecosystems 8, no. 2 (March 1998): 309–10. http://dx.doi.org/10.1002/(sici)1099-0755(199803/04)8:2<309::aid-aqc278>3.0.co;2-e.

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Klein, Y. Maximilian, Alessandro Prescimone, Edwin C. Constable, and Catherine E. Housecroft. "Manipulating connecting nodes through remote alkoxy chain variation in coordination networks with 4′-alkoxy-4,2′:6′,4′′-terpyridine linkers." CrystEngComm 17, no. 34 (2015): 6483–92. http://dx.doi.org/10.1039/c5ce01115a.

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A switch from a (6,3) to (4,4) net results from lengthening the chain in 4′-alkoxy-4,2′:6′,4′′-terpyridines in reactions with Cd(NO₃)₂·4H₂O; the assembly can be switched to a 1D-ladder if lower amounts of ligand are available.

Dadalova, A., E. Vasilenko, R. Samigullina та V. Mazurov. "AB0712 THE INCIDENCE OF SARS-СOV-2 INFECTION IN PATIENTS WITH RHEUMATIC DISEASES ON THERAPY BIOLOGICAL DISEASE MODIFYING ANTIRHEUMATIC DRUGS". Annals of the Rheumatic Diseases 80, Suppl 1 (19 травня 2021): 1387.3–1388. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4323.

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Background:At the moment, a highly relevant issue is the course of SARS-CoV-2 infection in patients with rheumatic pathology, especially, those receiving therapy with biological disease modifying antirheumatic drugs.Objectives:of the current study to assess the prevalence and course of SARS-CoV-2 infection in patients receiving various biological disease modifying antirheumatic drugs.Methods:to assess the severity of the course of SARS-CoV-2, discharged epicrisis from hospitals or the conclusion of computed tomography were used. The average age of the patients ranged from 41.4 + 11.6 years. In the evaluated sample, 47 patients (49.47%) were males. Among the infected of SARS-CoV-2 were patients with rheumatoid arthritis - 45 (47.4%), spondyloarthritis - 39 (41.1%), systemic connective tissue diseases - 11 (11.5%).Results:Since March 2020, among the 1319 patients with rheumatic diseases observed at the St. Petersburg Center of therapy biological disease modifying antirheumatic drugs, 95 patients (7,2%) had SARS-CoV-2 infection. In 57,9% (55 patients) there was a mild course of infection, in 35,8% of cases (34 patients) - a moderate course, in 6,3% (6 patients) - a severe course. Inpatient treatment was received by 29,5% (28 patients). A favorable outcome was noted in 95.8%, and a lethal outcome in 4,2%. The use of interleukin-6 inhibitors was required in 2,1% of patients (2) due to the development of a cytokine storm. The structure of the received biological therapy in the severity of the course is shown in Table 1.Table 1.The structure of the received biological therapy in the severity of the course SARS-CoV-2 infectionMild courseCT-1 (<25%)CT-2 (25-50%)CT-3 (50-75%)CT-4 (>75%)TNF-α inhibitors, n (%)30 (31,6)11 (11,6)7 (7,3)3 (3,2)0 (0,0)anti B-cell therapy (rituximab), n (%)2 (2,1)1 (1,1)2 (2,1)1 (1,1)2 (2,1)Abatacept, n (%)3 (3.2)0 (0,0)2 (2,1)0 (0,0)0 (0,0)Janus kinase inhibitors, n (%)5 (5,3)1 (1,1)1 (1,1)0 (0,0)0 (0,0)Interleukin-6 inhibitors, n (%)6 (6,3)0 (0,0)0 (0,0)0 (0,0)0 (0,0)Interleukin-17 inhibitors, n (%)8 (8,4) 2 (2,1) 2 (2,1)0 (0,0)0 (0,0)Other, n (%)1 (1,1)4 (4,2)1 (1,1)0 (0,0)0 (0,0)Among 95 infected patients, who were observed in the center, 51 received therapy with TNF-α inhibitors (8.5% of the total number of patients receiving therapy), 8 - rituximab therapy (2.7%), 5 - abatacept (6.3%), 7 - Janus kinase inhibitors (0.9%), 6 – interleukin-6 inhibitors (9.2), 12 - interleukin -17 inhibitors (14.1%), 6 patients treated with other drugs (10%).Conclusion:Taking into account the SARS-CoV-2 pandemic, further study of the course of infection in patients with rheumatic diseases, including those receiving biological therapy, is required. More information is also needed on the safety and efficacy of vaccination in this patient population.Disclosure of Interests:None declared

Glockling, F. "Book review: Organotin: environmental fate and effects, M A Champ and P F Seligman (eds), Chapman and Hall, London, 1996. 623 pages, �195.00. ISBN 0-412-58240-6." Applied Organometallic Chemistry 11, no. 9 (September 1997): 755–56. http://dx.doi.org/10.1002/(sici)1099-0739(199709)11:9<755::aid-aoc646>3.0.co;2-7.

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Дисертації з теми "623.452 6":

Terry, Paul. "Dietary prevention of gastrointestinal cancer : epidemiologic studies of fruit, vegetables and cereals /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4592-6/.

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Oscarson, Mikael. "Genetic polymorphism of human drug metabolising enzymes : structural and functional studies /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3717-6/.

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Schnack, Sven [Verfasser]. "Berechnung der Dauerfestigkeit und der Rissausgangsorte gepulst laserstrahlgehärteter Proben aus den Stählen 42 CrMo 4 und 100 Cr 6 / Sven Schnack." Aachen : Shaker, 2003. http://d-nb.info/1170544002/34.

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Книги з теми "623.452 6":

Theoretical, and experimental. Ukrainian-Polish 10 symposium: Theoretical and experimental studies of interfacial phenomena and their technological applications. Vol. 2. Lviv: ЛНУ ім. І. Франка, 2006.

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Якимович, Б. З. Іван Франко - видавець. Львів, 2006.

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Частини книг з теми "623.452 6":

Cieślak-Kopyt, Małgorzata. "Elementy obrządku pogrzebowego." In Ocalone Dziedzictwo Archeologiczne, 83–87. Wydawnictwo Profil-Archeo; Muzeum im. Jacka Malczewskiego w Radomiu, 2020. http://dx.doi.org/10.33547/oda-sah.10.zn.04.

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A total of 65 Przeworsk culture features were discovered in the Żelazna Nowa cemetery. This number included a rectangular groove feature, urned cremations (6), alleged/damaged urned cremations (14), unurned cremations (14), alleged/fully or partly damaged unurned cremations (27), pits containing no bone material (4), undtermined cremations (2), pits containing no archeological material (1). All of the explored burials are cremations. However, a more detailed analysis encounters problems due to the state of preservation of the graves. Features 3, 19A and 19B, 30, 33, 37, 39 have been confidently identified as urned cremations. In many other features fragments of ceramic vessels were found, which may be remains of damaged urns: 18, 21, 23, 25, 31, 35, 44, 46, 47, 48, 49, 56, 57, and 58. Certain unurned cremations are 4, 6, 7, 8, 11–13, 15–17, 22, 24, 32, and 34. The interpretation of the remaining features is uncertain. Among the features uncovered in the cemetery were pits containing no bones: 5, 60, 61, 62, as well as pits containing no archaeological material at all: 55. The majority of unurned cremations contained pyre debris, while no such remains were observed in the following damaged unurned cremations: 15, 40–42, 45, 61, 62. There were a few cases of double burials identified. Three unurned cremations (6, 13, 15) and one urned cremation (39) contained bones of Infans I and an undetermined individual, while feature 19 contained two urns with individual burials: Infans II and an undetermined individual. Urned cremations, and one alleged unurned cremation (56), are distinguished by a higher standard of furnishing and a considerably larger amount of bone remains. This can be given two interpretations: a higher status of those buried there, or different rituals used for urned and unurned cremations. In two graves the urn was covered with an upturned vessel (features 33 and 37). In one case, an apotropaic behaviour characteristic of the Przeworsk culture was recorded, involving driving sharp objects into the pit’s bottom: in grave 41 these were two spearheads.

Sánchez, Daniela Edith, Karla Alejandra Villarreal Arizpe, Fidel H. Torres, Mirna E. Dávila-García, Betzabe Irene Mesías-Gámez, Jesús Antonio Morón-Mosso, Daniela García Escandón Miranda, et al. "They Won't Teach You This in School." In Advancing Health Education With Telemedicine, 123–43. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-8783-6.ch007.

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Diabetes mellitus (DM) has shown growing global morbidity, thus becoming a public health priority. In 2017, approximately 425 million people suffered from diabetes, and it is estimated that by 2045 the number will increase to 629 million. Type 2 diabetes mellitus (DM2), with 90% of reported cases, is the most common type and is followed by type 1. In 2018, 8.6 million people over 20 years of age were diagnosed with diabetes in Mexico. This represents 10.6% of the population. In some states with a higher incidence such as Nuevo León, it is estimated that 12.6% of the population above 20 years has been diagnosed with DM. This chapter seeks to inform about type 2 Diabetes Mellitus, its way of acting and complications that it entails, and how social media can be advantageous in patient education.

Bygrave, Lee A., and Luca Tosoni. "Article 4(11). Consent." In The EU General Data Protection Regulation (GDPR). Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198826491.003.0017.

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Article 5 (Principles relating to processing of personal data) (see also recitals 33, 39 and 50); Article 6(1)(a) (Lawfulness of processing on basis of consent) (see too recital 40); Article 7 (Conditions for consent) (see also recital 42); Article 8 (Conditions applicable to child’s consent in relation to information society services) (see too recital 38); Article 9(2)(a) (Processing of special categories of personal data on basis of consent) (see too recital 51); Article 13 (Information to be provided where personal data are collected from the data subject) (see too recitals 60–62); Article 14 (Information to be provided where personal data have not been obtained from the data subject); Article 17 (Right to erasure) (see too recital 65); Article 20 (Right to data portability) (see too recital 68); Article 22 (Automated individual decision-making, including profiling) (see too recital 71); Article 49(1)(a) (Transfer of personal data to third country or international organisation on basis of consent) (see too recitals 111–112).

Luk, Jeremy W., Stephen E. Gilman, Denise L. Haynie, and Bruce G. Simons-Morton. "Sexual Orientation and Depressive Symptoms in Adolescents." In Pediatric Collections: LGBTQ+: Support and Care (Part 2: Health Concerns and Disparities), 12–21. American Academy of Pediatrics, 2021. http://dx.doi.org/10.1542/9781610025409-sexual.

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OBJECTIVES Sexual orientation disparities in adolescent depressive symptoms are well established, but reasons for these disparities are less well understood. We modeled sexual orientation disparities in depressive symptoms from late adolescence into young adulthood and evaluated family satisfaction, peer support, cyberbullying victimization, and unmet medical needs as potential mediators. METHODS Data were from waves 2 to 6 of the NEXT Generation Health Study (n = 2396), a population-based cohort of US adolescents. We used latent growth models to examine sexual orientation disparities in depressive symptoms in participants aged 17 to 21 years, conduct mediation analyses, and examine sex differences. RESULTS Relative to heterosexual adolescents, sexual minority adolescents (those who are attracted to the same or both sexes or are questioning; 6.3% of the weighted sample) consistently reported higher depressive symptoms from 11th grade to 3 years after high school. Mediation analyses indicated that sexual minority adolescents reported lower family satisfaction, greater cyberbullying victimization, and increased likelihood of unmet medical needs, all of which were associated with higher depressive symptoms. The mediating role of cyberbullying victimization was more pronounced among male than female participants. CONCLUSIONS Sexual minority adolescents reported higher depressive symptoms than heterosexual adolescents from late adolescence into young adulthood. Collectively, low family satisfaction, cyberbullying victimization, and unmet medical needs accounted for >45% of differences by sexual orientation. Future clinical research is needed to determine if interventions targeting these psychosocial and health care–related factors would reduce sexual orientation disparities in depressive symptoms and the optimal timing of such interventions.

Taber, Douglass. "Enantioselective Assembly of Aminated Stereogenic Centers." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0033.

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Although natural amino acids are readily available, there is a continuing need for unnatural amino acids. Jon C. Antilla of the University of South Florida has described (J. Am. Chem. Soc. 2007, 129, 5830) a promising approach, based on the enantioselective organocatalytic reduction of imines such as 1 derived from α-keto esters. The aryl group is easily removed to give the primary amine. Mukund P. Sibi of North Dakota State University has developed (J. Am. Chem. Soc. 2007, 129, 4522) an enantioselective Mg catalyst that mediated the addition of benzyl hydrazine 6 to imides such as 5. The initial adduct cyclized to the pyrazolidinone 7. Karl Anker Jørgensen of Aarhus University has reported (Angew. Chem. Int. Ed. 2007, 46, 1983) a complementary protocol for the enantioselective conjugate addition of a nitrogen nucleophile. Enantioselective homologation can also be a powerful approach. Benjamin List of the Max-Planck-Institute, Mülheim has found (Angew. Chem. Int. Ed. 2007, 46, 612; Organic Lett. 2007, 9, 1149) that three-component coupling of acetyl cyanide, an aldehyde and benzylamine under the influence of the Jacobsen thiourea catalyst 10 delivered the onecarbon homologated nitrile 12 in high ee. Other homologation methods are also effective. Li Deng of Brandeis University has shown (Organic Lett. 2007, 9, 603) that under the influence of cinchona-derived quaternary salts, malonates will add to racemic amido sulfones such as 13 to give the β-amino malonate 14 in high ee. Fujie Tanaka and Carlos F. Barbas III of Scripps/La Jolla have found (Angew. Chem. Int. Ed. 2007, 46, 1878) that the simple organocatalyst proline will mediate the aza-Baylis Hillman addition of an unsaturated aldehyde such as 15 to 16 in high ee. The alkene 17 is the kinetic product. On prolonged exposure to the reaction conditions, 17 was equilibrated to the more stable 18 . Ming-Hua Xu and Guo-Qiang Lin of the Shanghai Institute of Organic Chemistry have established (J. Am. Chem. Soc. 2007, 129, 5336) a robust protocol for the enantioselective assembly of -arylated benzylamines such as 21.

Becerra-Culqui, Tracy A., Yuan Liu, Rebecca Nash, Lee Cromwell, W. Dana Flanders, Darios Getahun, Shawn V. Giammattei, et al. "Mental Health of Transgender and Gender Nonconforming Youth Compared With Their Peers." In Pediatric Collections: LGBTQ+: Support and Care Part 1: Combatting Stigma and Discrimination, 14–24. American Academy of Pediatrics, 2021. http://dx.doi.org/10.1542/9781610024730-mental_health.

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BACKGROUND Understanding the magnitude of mental health problems, particularly life-threatening ones, experienced by transgender and/or gender nonconforming (TGNC) youth can lead to improved management of these conditions. METHODS Electronic medical records were used to identify a cohort of 588 transfeminine and 745 transmasculine children (3–9 years old) and adolescents (10–17 years old) enrolled in integrated health care systems in California and Georgia. Ten male and 10 female referent cisgender enrollees were matched to each TGNC individual on year of birth, race and/ or ethnicity, study site, and membership year of the index date (first evidence of gender nonconforming status). Prevalence ratios were calculated by dividing the proportion of TGNC individuals with a specific mental health diagnosis or diagnostic category by the corresponding proportion in each reference group by transfeminine and/or transmasculine status, age group, and time period before the index date. RESULTS Common diagnoses for children and adolescents were attention deficit disorders (transfeminine 15%; transmasculine 16%) and depressive disorders (transfeminine 49%; transmasculine 62%), respectively. For all diagnostic categories, prevalence was severalfold higher among TGNC youth than in matched reference groups. Prevalence ratios (95% confidence intervals [CIs]) for history of self-inflicted injury in adolescents 6 months before the index date ranged from 18 (95% CI 4.4–82) to 144 (95% CI 36–1248). The corresponding range for suicidal ideation was 25 (95% CI 14–45) to 54 (95% CI 18–218). CONCLUSIONS TGNC youth may present with mental health conditions requiring immediate evaluation and implementation of clinical, social, and educational gender identity support measures.

"work 1894 6 1894 1 0.87 1894 3 1894 440.93 1894 6 1894 146 148 880.99 1894 178 9 46 1894 240 0.98 1894 272 1894 319 329 0.99 1916 379 364 0.96 1916 449 402 433 0.93 1916 460 499 0.92 1916 592 546 0.94 1916 655 629 665 0.95 1916 723 720 38 38 1.00 1916 794 807 842 42 0.96 1916 872 905 46 0.97 1916 949 1916 1020 0.99 1916 1099 1188 63 1277 1359 1498 1596 1703 1748 1830 1857 98 1879." In Planning, Estimating, and Control of Chemical Construction Projects, 425. CRC Press, 2001. http://dx.doi.org/10.1201/9781482270815-152.

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"are purified lipid contents and others are not, and the puri-(Paspalum scrobiculatum), and barnyard (Echinocloa fied lipid content depends on the purification method. colona). Sridhar and Lakshminarayana [32] also reported Starch lipids (SL) are those bound to starch, and they FL contents of 5.0, 5.6, and 2.2% for Proso, Foxtail, and are the most difficult to extract. Since true SL are present Finger millet, respectively. Taira [45] found slightly high-inside the starch granules, even a very polar solvent such er average FL (ether extraction) contents for glutinous as WSB cannot extract them at ambient temperature. Effi-foxtail millet (4.2-5.1%, average 4.7% of 21 samples) cient extraction of SL requires mixtures of hot aqueous al-than for nonglutinous foxtail millet (4.0-4.7%, average cohol in proportions optimized for controlled swelling of 4.4% of 31 samples). Among millet, pearl millet contains the starch granules and solubilization of the lipids [25]. the most FL. The best solvents are n-propanol or isopropanol with water Lipid contents of rice in Table 2 were cited by Morrison (3:1, by volume) used under nitrogen at 100°C. However, [3] using the data of Nechaev and Sandler [2]. Taira and some n-butanol—water and methanol-water mixtures also Chang [46] reported that the average nonglutinous brown are reasonably efficient extraction solvents at 100°C [25]. rice FL (ether extraction) contents of 20 varieties each of Recently, a third lipid category was introduced. Starch sur-Indica and Japonica types were 2.7% (2.38-2.91%) and face lipids (SSL) are portions of the nonstarch lipids 2.9% (2.54-3.58%), respectively. More recently, Taira et (NSL), which become firmly absorbed onto or into starch al. [47] reported the average FL contents of 15 nongluti-granules during the separation of pure starch [24]. nous varieties as 2.5% (2.24-2.97%) for Indica, 2.5% Lipids are minor components of the cereal grains shown (2.12-2.94%) for Japonica, 2.7% (2.35-3.03%) for Sinica, in Table 2. Data in this table, expressed on a dry basis, and 2.6% (2.11-2.99%) for Japonica types. were calculated from reported values [3,16,26-41]. Also, some BL or TL contents were calculated by subtracting FL from TL or by adding FL to BL, depending on the avail-B. Nonstarch Lipid Classes of Grains ability of data. The FL contents range from 1.5 to 2% of Lipids can be separated into three broad classes by open-the kernel weights of barley, rice, rye, triticale, and wheat column silicic acid chromatography. Nonpolar lipids (NL) grains. They range from 3 to 7% of the kernel weights of are first eluted by chloroform, glycolipids (GL) are eluted oats, millet, corn, and sorghum. However, BL contents in next by acetone, and phospholipids (PL) are eluted last grains are more uniform than FL contents. Therefore, the with methanol. Mixtures of GL and PL are polar lipids FL:BL ratio is substantially higher for corn, millet, oats, (PoL). After NL elution from a silicic acid column, PoL and sorghum than for rye, triticale, and wheat grains. The can be eluted with methanol without the GL elution step. FL:BL ratios for barley and rice are intermediate. Lipids can also be separated into various classes by thin-High oil-containing grains such as corn are continuous-layer chromatography (TLC) using different development ly bred for higher oil content with improved production solvent systems. Each individual lipid class migrates dif-yield. Application of wide-line NMR spectroscopy for ferently on the thin-layer plate, and the difference in mi-nondestructive analysis of the oil content in single corn gration rates makes it possible to separate complex lipids kernels made selection for higher oil content more efficient into classes. The NL consists of SE, TG, DG, MG, and [42]. Corn hybrids with 6-8.5% oil content and grain FFA (see Table 1). The total NL content is obtained by yields equal to those of good commercial hybrids were adding these NL class contents as measured by densitome-produced [43]. try. Thus, the NL content of samples may differ, to some Several kinds of millet exist, and the lipid data in the extent, depending on methodology used (column separa-literature are confusing. Rooney compared the FL (ether tion or TLC separation). extraction) contents of several types of millet in a review The data [1,13,27,29,32,36-38,40,48-58] shown in paper [16]. The average FL contents of pearl millet (Pen-Table 3 may be used for only approximate comparison of nisetum typhoids) were 5.1% (4.1-5.6%, 14 samples), the NL content from different grains because some were 5.4% (2.8-8.0%, 167 samples, [44]), 5.6% (4.3-7.1%, 40 obtained by column chromatography and some by TLC. samples), and 6.2% (4.2-7.4%, 35 samples) [16]. Other All cereal grain lipids are richer in NL than in other class-reported average FL contents were 4.8% (4.6-5.0%, 6 es: 60-70% of the TL are NL in wheat (hexaploid), triti-samples) for foxtail millet (Setaria Italica), 5.8% cale, and rye; 65-80% for barley and oat groats; 77-87% (5.5-6.3%, 6 samples) for Japanese millet (Echinochloa for sorghum and rice; and 75-96% for corn and millet crusgalli), and 4.2% (3.8-4.9%, 20 samples) for proso (Pennisetum americanum). Sridhar and Lakshminarayana millet (Panicum miliaceum) [16]. Sridhar and Lakshmi-[32] reported 82, 80, and 79% of NL for Foxtail, Proso, narayana [30] reported a FL content range of 3.4-5.7% for and Finger millet, respectively. There are significant vari-small millet, including little (Panicum sumatrense), kodo etal effects on the NL/PoL ratio for corn and millet (P." In Handbook of Cereal Science and Technology, Revised and Expanded, 434. CRC Press, 2000. http://dx.doi.org/10.1201/9781420027228-43.

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Тези доповідей конференцій з теми "623.452 6":

Zhang, Yawen, Qin Lv, Duanfeng Gao, Si Shen, Robert Dick, Michael Hannigan, and Qi Liu. "Multi-Group Encoder-Decoder Networks to Fuse Heterogeneous Data for Next-Day Air Quality Prediction." In Twenty-Eighth International Joint Conference on Artificial Intelligence {IJCAI-19}. California: International Joint Conferences on Artificial Intelligence Organization, 2019. http://dx.doi.org/10.24963/ijcai.2019/603.

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Accurate next-day air quality prediction is essential to enable warning and prevention measures for cities and individuals to cope with potential air pollution, such as vehicle restriction, factory shutdown, and limiting outdoor activities. The problem is challenging because air quality is affected by a diverse set of complex factors. There has been prior work on short-term (e.g., next 6 hours) prediction, however, there is limited research on modeling local weather influences or fusing heterogeneous data for next-day air quality prediction. This paper tackles this problem through three key contributions: (1) we leverage multi-source data, especially high-frequency grid-based weather data, to model air pollutant dynamics at station-level; (2) we add convolution operators on grid weather data to capture the impacts of various weather parameters on air pollutant variations; and (3) we automatically group (cross-domain) features based on their correlations, and propose multi-group Encoder-Decoder networks (MGED-Net) to effectively fuse multiple feature groups for next-day air quality prediction. The experiments with real-world data demonstrate the improved prediction performance of MGED-Net over state-of-the-art solutions (4.2% to 9.6% improvement in MAE and 9.2% to 16.4% improvement in RMSE).

Vasconcellos, Bruna Obeica, Anna Carolina Leal Bittencourt, Larissa Abrahão Fernandes Cirto, and Jacqueline Assumção Silveira Montuori. "Endometriose profunda com acometimento intestinal e abordagem da infertilidade em Clínica da Família: relato de caso." In 45º Congresso da SGORJ XXIV Trocando Ideias. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/jbg-0368-1416-20211311034.

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Introdução: A endometriose é caracterizada pela presença de tecido endometrial fora do útero. Os sintomas são variáveis, mas quando presentes se limitam a dismenorreia, dispareunia, dor pélvica e infertilidade. Tem maior prevalência em mulheres de menarca precoce, largo tempo entre menarca e primeira gestação e gestação tardia. Possui etiologia desconhecida, baixa qualidade dos ovócitos, aderências e infiltrações endometriais que alteram a anatomia da pelve, dificultando transporte e implantação. É uma das principais causas de infertilidade em 50% das mulheres com problemas de fecundidade. O diagnóstico usual é tardio, confirmado por videolaparoscopia, e quanto mais tarde pior o prognóstico. O tratamento medicamentoso não atua na infertilidade, apenas na progressão da doença. Quanto à fertilidade, resultados obtidos após tratamento cirúrgico ou por reprodução assistida são compatíveis com os de mulheres sadias. Relato de caso: A.M.R., 41 anos, G0P0, natural de Sobral/CE e residente do Rio de Janeiro/RJ, casada há oito anos. Procura o atendimento ginecológico na Clínica da Família com o desejo de engravidar. Esposo com dois filhos prévios. Fazia uso de anticoncepcional oral e por três meses tentou engravidar de forma natural, sem sucesso. Iniciou intensa dor pélvica relacionada ao período menstrual, realizou ressonância magnética de pelve, que mostrou: útero em anteversoflexão de 7,8x4,2x5,3 cm e leiomioma subseroso de 1,2 cm. Ovários normais com folículos. Endometriomas localizados em ovário esquerdo de 0,8 cm, 1,5 cm e 1,9 cm e, em ovário direito, um de 0,4 cm. Presença de hidrossalpinge esquerda de 6 cm. Placas endometrióticas infiltrativas de parede anterior do retossigmoide de 6,3 cm, comprometendo 25% da circunferência. Diante disso, fez uso de dienogeste por dois meses, com melhora dos sintomas da dor, e foi encaminhada para serviço hospitalar de ginecologia cerca de cinco meses após o início dos sintomas. Conclusão: O tratamento deve ser individualizado e considerar sempre os sintomas da paciente, a apresentação da doença e o desejo ou não de gestar. É fundamental que uma equipe multidisciplinar esteja presente no tratamento, atuando no manejo do controle e da reincidência da doença. Em nível ambulatorial em Clínica da Família, a abordagem da infertilidade é limitada, sendo necessário o encaminhamento a instituições de maior especialização e/ou alto risco, como no caso relatado. Além de serem escassos os serviços que realizam tratamentos de fertilidade gratuitos, a maioria utiliza idades entre 35 e 40 anos como critério de seleção e conta com razoável tempo de espera. Assim, a paciente não só extrapola o período selecionado, como apresenta mais dificuldades em gestar, tendo como último recurso a fertilização in vitro e com ovo doação. Dessa forma, o diagnóstico tardio impacta de formas desastrosas a qualidade de vida da mulher, principalmente pelo tempo contado da fertilidade.

Eltai, Nahla Omer, Hadi M. Yassine, Sara H. Al-Hadidi, Tahra ElObied, Asmaa A. Al Thani, and Walid Q. Alali. "Retail Chicken Carcasses as a Reservoir of Antimicrobial- Resistant Escherichia coli." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0115.

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The dissemination of antimicrobial resistance (AMR) bacteria has been associated with the inappropriate use of antibiotics in both humans and animals and with the consumption of food contaminated with resistant bacteria. In particular, the use of antibiotics as prophylactic and growth promotion purposes in food-producing animals has rendered many of the antibiotics ineffective. The increased global prevalence of AMR poses a significant threat to the safety of the world’s food supply. Objectives: This study aims at determining the prevalence of antibiotic-resistant Escherichia coli (E. coli) isolated from local and imported retail chicken meat in Qatar. Methodology: A total of 270 whole chicken carcasses were obtained from three different hypermarket stores in Qatar. A total of 216 E. coli were isolated and subjected to antibiotic susceptibility testing against 18 relevant antibiotics using disc diffusion and micro- dilution methods. Furthermore, extended-spectrum β-lactamase (ESBL) production was determined via a double-disc synergetic test. Isolates harboring colistin resistance were confirmed using multiplex-PCR and DNA sequencing. Results: Nearly 89% (192/216) of the isolates were resistant to at least one antibiotics. In general, isolates showed relatively higher resistance to sulfamethoxazole (62%), tetracycline (59.7%), ampicillin and trimethoprim (52.3%), ciprofloxacin (47.7%), cephalothin, and colistin (31.9%). On the other hand, less resistance was recorded against amoxicillin/clavulanic acid (6%), ceftriaxone (5.1%), nitrofurantoin (4.2%) and piperacillin/tazobactam (4.2%), cefepime (2.3%), meropenem (1.4%), ertapenem (0.9%), and amikacin (0.9%). Nine isolates (4.2%) were ESBL producers. Furthermore, 63.4% were multidrug-resistant (MDR). The percentage of MDR, ESBL producers, and colistin-resistant isolates was significantly higher among local isolates compared to imported chicken samples. Conclusion: We reported a remarkably high percentage of the antibiotic-resistant E. coli in chicken meat sold at retail in Qatar. The high percentage of MDR and colistin isolates is troublesome to the food safety of raw chicken meat and the potential of antibiotic resistance spread to public health. Our findings support the need for the implementation of one health approach to address the spread of antimicrobial resistance and the need for a collaborative solution.

Santiago Gutiérrez, Luz Goretti, Mª Teresa Santana Rodríguez, and Cristina Mª Cabrera Hernández. "TRASTORNO POR USO DE ALCOHOL Y TRASTORNO MENTAL. INFLUENCIA DE LA CONCOMITANCIA EN LA EFECTIVIDAD DE LA INTERVENCIÓN AMBULATORIA." In 23° Congreso de la Sociedad Española de Patología Dual (SEPD) 2021. SEPD, 2021. http://dx.doi.org/10.17579/sepd2021o023.

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INTRODUCCION La Patología Dual (PD) en el consumo de alcohol condiciona el pronóstico, adherencia y retención en la intervención ambulatoria. OBJETIVOS Conocer prevalencia de patología dual. Determina tasas de adherencia a consulta y tratamiento. Analizar correlación PD cumplimiento y efectividad terapéutica. METODO Estudio descriptivo observacional longitudinal. Referencia muestral: 77 pacientes con TUA de 472 incluidos en Plan de Microeliminación del VHC de San Miguel Adicciones (2017 a 2020). Variables de estudio: sociodemográficas, clínicas y de consumo e indicadores de cumplimiento y retención. RESULTADOS Muestra: 62% hombres y 38% mujeres (34 y 70 años). 52% Patología Dual (69%M; 42%H). Patologías psiquiátricas: 22% trastorno depresivo (53%H;47%M), 7% ansiedad (60%H;40%M), 8% síndrome ansioso depresivo (34%H;66%M). Tentativas autolíticas 16%, (42%H;58%M), 7% más de un trastorno psiquiátrico. Acuden por Iniciativa Propia 49%, derivación MAP (25%), Especializada 9%. La retención es superior en los pacientes que no tienen PD (>12 meses). Menor índice de retención en pacientes con trastorno psiquiátrico 40%. Trastorno Depresivo: 82% de adherencia a consulta (AC), 47% de retención (R) > 6 meses, 29% abandona (A) y 24% alta terapéutica (AT). Trastorno de Ansiedad: 20%(AC), 60% (R) >6 meses, 40% (A), 0% (AT). Trastorno Ansioso-Depresivo: 10% (AC), 67%(R) > 6 meses, 50% (A) y 33% (AT). CONCLUSIONES Predominio de trastornos afectivos: depresión, ansiedad. Diferencia en el factor género en TUA y PD. Prevalencia de más de un Trastorno Mental superior en mujeres. Escasa derivación desde los Servicios Especializados. La concurrencia PD-TUA incide de manera desfavorable en pronóstico, evolución y efectividad terapéutica. References 1. Corrêa Filho JM, Baltieri DA. Psychosocial and clinical predictors of retention in outpatient alcoholism treatment. Braz J Psychiatry. 2012 -12;34(4):413-21. 2. Graff FS, Morgan TJ, Epstein EE, McCrady BS, Cook SM, Jensen NK, et al. Engagement and retention in outpatient alcoholism treatment for women. Am J Addict. 2009 Jul-Aug;18(4):277-88.

Rao, J. S., J. Neelima, and G. Srikanth. "A Technoeconomic Comparison of IGCC Power Plants With Cold Gas Cleanup and Hot Gas Cleanup Units Using Indian Coals." In International Joint Power Generation Conference collocated with TurboExpo 2003. ASMEDC, 2003. http://dx.doi.org/10.1115/ijpgc2003-40018.

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Bulk of CO2 emission comes from thermal power generation, which constitutes about 63% of total installed capacity of around 101.6 GWe. The policy makers and power utilities are increasingly favoring the introduction of clean coal technologies, which release less pollutants viz. CO2, NOx and SOx than the conventional thermal plants and have potential to operate at higher efficiencies above 42–44%. Among the clean coal technologies, Integrated Gasification Combined Cycle (IGCC) is being considered the most promising because of higher thermal efficiencies and improved environmental performance. IGCC has the added advantage of removing sulphur pollutants in bed using sorbent as against expensive external post combustion flue gas desulphurisation systems. It is proposed to set up 100MWe-demonstration plant for proving the emission standards and performance prior to commercialization. This plant is based on Frame 6 FA gas turbine designed for low Btu gas firing. The Paper presents the technical parameters and compares the overall project cost of 100MWe IGCC plant for both Cold gas cleanup unit (CGCU) and Hot gas cleanup unit (HGCU), which comprises of Gasification Island, power block, and balance of plant. Being first of kind the project cost is higher and the project cost is likely to get reduced for utility scale of 425 MW IGCC plants in future.

"TRASTORNO POR USO DE ALCOHOL Y TRASTORNO MENTAL. LA COMORBILIDAD COMO FACTOR PREDICTOR DE LA EVOLUCIÓN TERAPÉUTICA." In 23° Congreso de la Sociedad Española de Patología Dual (SEPD) 2021. SEPD, 2021. http://dx.doi.org/10.17579/sepd2021p145v.

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INTRODUCCION El pronóstico y evolución en el Trastorno por Uso de Alcohol (TUA) y Trastorno Mental (TM) está condicionada por la multifactorialidad: falta de adherencia, recaídas, y complicaciones orgánicas. OBJETIVOS Identificar patología psiquiátrica concomitante. Analizar las tasas de adherencia a consulta y tratamiento. Correlacionar patología psiquiátrica con índices de retención. METODO Estudio descriptivo observacional longitudinal. Referencia muestral: 77 pacientes con TUA de 472 incluidos en Plan de Microeliminación del VHC de San Miguel Adicciones (2017 a 2020). Variables de estudio: sociodemográficas, clínicas y de consumo e indicadores de cumplimiento y retención. RESULTADOS Muestra: 62% hombres y 38% mujeres (34 y 70 años). Inicio del consumo de alcohol entre 15 y 18 años. Presentan Patología Dual 69% mujeres y 42% hombres. 85% de pacientes con TUA presentan un solo TM concomitante (95% hombres, 80% mujeres). Patología psiquiátrica predominante: Trastorno Depresivo 22% (H:53%;M:47%), Trastorno de Ansiedad 7% (H:60%;M:40%), Trastorno Ansioso Depresivo 8% (H:34%;M:66%). Destacar la prevalencia de un 18% de mujeres con Trastorno Psicótico. El 58% de mujeres han realizado uno o más Gesto Autolítico. Acuden por Iniciativa Propia 49%, derivación MAP (25%), Especializada 9%. Trastorno Depresivo: 82% de adherencia a consulta, 47% de retención superior a 6 meses. Trastorno de Ansiedad (20%) y 60% de retención entre 6 y 12 meses. CONCLUSIONES Mujeres con TUA presentan más comorbilidad psiquiátrica. La prevalencia de más de un Trastorno Mental es superior en mujeres. El Trastorno Depresivo es el de mayor incidencia con TUA. Escasa derivación desde los Servicios Especializados. References 1. Corrêa Filho JM, Baltieri DA. Psychosocial and clinical predictors of retention in outpatient alcoholism treatment. Braz J Psychiatry. 2012 -12;34(4):413-21. 2. Graff FS, Morgan TJ, Epstein EE, McCrady BS, Cook SM, Jensen NK, et al. Engagement and retention in outpatient alcoholism treatment for women. Am J Addict. 2009 Jul-Aug;18(4):277-88.

Kornberg, A., S. Kaufman, L. Silber, and J. Ishay. "THE EFFECT OF THE VENOM OF THE ORIENTAL HORNET ON COAGULATION FACTORS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644338.

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The extract from the venom sac of Vespa orientalis (VSE) inactivates exogenous and endogenous thromboplastin (Joshua and Ishay, Toxicon, 13:11-20,1975). The prolongation of both prothrombin time (PT) and recalcification time suggests inactivation of other factors. The aim of the present study is to investigate the effect of VSE on clotting factors. A lyophilized VSE with protein concentration of 5 mg/ml was used. Studies were performed in vitro with human plasma and in vivo in cats. Routine methods were employed for the assay of PT, activated tissue thromboplastin (APTT), thrombin time (TT), fibrinogen degradation products (FDP), fibrinogen and factors V,VII,VIII,IX,X. Human plasma was incubated with various concentrations of VSE (0,1,5,10,50,100 μg/ml) for 60 min and for various incubation times (0,5,15,30,+ 60,90,120 min) with 50 μg/ml VSE (n=8). 1 μg/ml VSE prolonged PT from 13.5 to 16 sec (p<0.05) and APTT from 62 to 180 sec. PT was maximal (17.7 sec) with 10 μg/ml and APTT (442 sec) with 50 μg/ml VSE. Factors V,VII,X decreased gradually from 94-105% to 11%,11% and 29% with 100 μg/ml VSE and VIII and IX to 1% even with 1 μg/ml VSE. After 5 min with constant concentration of VSE (50 μg/ml) PT was 14.9 sec (normal 13 sec) and APTT 165 sec (normal 54 sec). Both were maximal (17.5 and 298 sec) after 60 min. Factors VII and X decreased to 13% and 32% and VIII and IX to >1% after 60 min of incubation. Injection of 5 mg/kg VSE to cats (n=6-8) resulted in prolongation of PT from 9.4 to 11.2 sec and of APTT from 19.5 to 63 sec after 5 min. Both were maximal after 90 min (12.3 and 127 sec). Factors V,VII and X decreased from 100% to 7.6%, 13% and 37% and VIII and IX to 1% after 10 min. In all experiments TT and plasma fibrinogen were not affected and FDP were normal. Heating of VSE for 5 min at 80°C abolished completely the anticoagulant activity but dialysis for 24 hr at 4°C had no effect on it. The activity was eluted on Sephadex-25 both in void and post void volumes. The results show that VSE has a potent anticoagulant activity against various factors. Factors VIII and IX are markedly decreased. The effect on V, VII and X is moderate. Plasma fibrinogen is not affected. The nature and clinical significance of the anticoagulant activity merit further investigation.