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Дисертації з теми "Age factors in disease"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 29 липня 2024

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1

Swann, Peter G. "The visual field in age related maculopathy." Thesis, Queensland University of Technology, 1988. https://eprints.qut.edu.au/36726/1/36726_Swann_1988.pdf.

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Age-related maculopathy (ARM) is a leading cause of permanent vision loss in elderly people. ARM therefore constitutes an important public health problem which will increase in magnitude as the number of aged people in the general population becomes greater. The consequences of this condition are exacerbated by the fact that treatment, especially of the geographic or dry form of the disease, is ineffective. While laser photocoagulation may be helpful in the exudative, disciform or wet form of ARM, there is often an inexorable progression towards severe vision loss in these patients. Th

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2

MacIntosh, Caroline Gabrielle. "Investigation of the 'anorexia of ageing'." Title page, contents and summary only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phm15187.pdf.

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Includes bibliographical references (leaves 349-421) Addresses some of the mechanisms which may potentially contribute to the physiological anorexia of ageing, as suggested by previous animal and human studies.

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3

STEBBINS, GLENN THURSTON III. "MEMORY FUNCTIONING IN PARKINSON'S DISEASE: THE EFFECT OF AGE OF ONSET ON HIGH SPEED MEMORY SCANNING." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184223.

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A sample of 25 idiopathic Parkinson's disease subjects and 25 age and education matched elderly healthy control subjects were assessed for their speed of primary memory scanning speed using the Sternberg memory scanning paradigm. In addition, all patients were assessed for cognitive functioning as measured by the Mattis Dementia Rating Scale and the Wechsler Memory Scale. Significant differences were found between Parkinson's disease subjects and control subjects on speed of primary memory scanning, with the parkinsonian subjects performing significantly slower than the control subjects. Incre

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4

Allen, Annette Marie. "AIDS and Aging: Are the Eldery Becoming the New At-Risk Population?" Thesis, University of North Texas, 1994. https://digital.library.unt.edu/ark:/67531/metadc278037/.

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This dissertation breaks new ground. It examines the perceptions of older adults towards AIDS prevention. Using the National Health Interview Survey, 1988: AIDS Knowledge and Attitudes Supplement, a modified Health Belief Model is developed. Despite the low number of older adults 55+ with AIDS, some extenuating circumstances increase their risk of AIDS contraction. Older adults have lower levels of knowledge about AIDS, weaker immune systems and receive more blood transfusions. Societal influences include educational neglect at the hands of physicians, healthcare workers and social service per

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5

SWANDA, REX MICHAEL. "FREE RECALL AS A FUNCTION OF AGE OF ONSET, MEDICATIONS, AND DEPRESSION IN PARKINSON'S DISEASE." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/188054.

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Thirty-two parkinsonians were compared to 32 age-, sex-, and education-matched healthy controls on measures of depression (Beck Inventory), dementia (Mattis Dementia Rating Scale), and primary and secondary memory components of Free Verbal Recall. Parkinsonians were found to be more depressed, with greater impairment of secondary memory. There were no significant group differences in primary memory or general cognitive functioning. Sub-groups of 41 parkinsonians (including the 32 patients described above) were used to compare the relative contributions of depression, age of onset, and general

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6

Seth, Aruna. "Age-associated alterations in the immune system of normal and autoimmune-susceptible mice." Diss., This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-07282008-135119/.

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7

Cole, Leonie J. "Pain perception and processing in ageing and Alzheimer's disease /." Connect to thesis, 2009. http://repository.unimelb.edu.au/10187/4543.

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8

Mui, Tammy. "Exploring biological risk factors of chronic obstructive pulmonary disease : old age and female sex." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/24015.

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Chronic obstructive pulmonary disease (COPD) has various risk factors including old age and female sex; however, the biological reasoning behind these is not fully understood. COPD prevalence and mortality increase with age. COPD patients also seem to demonstrate pulmonary and systemic accelerated aging. When people age, repetitive sequences at their chromosomes ends, called telomeres, shorten. In COPD this may occur at an increased rate due to increased cell turnover or DNA damage, caused by inflammation and oxidative stress, and could contribute to lung function decline. Therefore, we measur

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9

Jump, Seth. "Fgf2-stimulated proliferation is lower in muscle precursor cells from old rats." Diss., Columbia, Mo. : University of Missouri-Columbia, 2009. http://hdl.handle.net/10355/6775.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2009.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2009" Includes bibliographical references.

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10

Vishnivetskaya, Anastasia. "Age is a risk factor for Aβ₄₂ proteotoxicity in Drosophila melanogaster". Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610287.

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11

Tlou, Boikhutso. "Statistical methods to model the influence of age and gender on the behavioral risk factors of HIV/AIDS." Thesis, University of Fort Hare, 2010. http://hdl.handle.net/10353/400.

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The effects of gender and age on the behavioral risk of HIV/AIDS are not clearly understood as previous distinct studies which have been carried out, have given disputable and contradictory outcomes. This study therefore, discusses the statistical methods which can be used to model the influence of age and gender on the behavioral risk factors of HIV/AIDS. In general, generalized linear models are the main methods which can be applied to depict the impact of age and gender on the behavioral risk of becoming infected with HIV/AIDS virus. In this study, the main methods used were logistic regres

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12

Hoh, Kam M. J. "Age-related changes in the retina and the risk factors leading to the onset of disease." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1333225/.

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Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness in those over 50 years old in Western countries. It is a late-onset, neurodegenerative retinal disease, which is characterised by extracellular deposits containing amyloid beta peptides (Aβ) on the Bruch’s membrane. In half of AMD cases, polymorphisms in the gene encoding complement factor H (CFH) are associated with susceptibility to the disease. The aims of this thesis were; (1) to identify sites of Aβ accumulation in mouse ageing eye and macrophage up-regulation, (2) to investigate the effects of imm

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13

Gibbs, John P. "Age-dependent busulfan disposition and its relation to GSTA1-1 expression /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/7931.

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14

Profant, Judith. "Fatigue and sleep complaints in women treated for breast cancer /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3129934.

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15

Lindoff, Claes. "Haemostasis during pregnancy and perimenopausal age studies of fibrinolytic components and coagulation factors involved in vascular disease /." Lund : Dept. of Obstetrics and Gynaecology, Lund University, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39750405.html.

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16

Cornett, Patricia F. Hall James. "Factors of the geriatric depression scale that may distinguish between four cognitive diagnostic groups normal, mild cognitive impairment, dementia of the Alzheimer's type, and vascular dementia /." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/ark:/67531/metadc12105.

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17

Wong, Jencia. "Age of diagnosis as a factor in the heterogeneity of type 2 diabetes: a clinical and molecular study." Thesis, The University of Sydney, 2009. https://hdl.handle.net/2123/28210.

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The age range at which type 2 diabetes develops has recently expanded. Thus chronological age and age of onset are now important variables in this already heterogeneous disease. The increasing prevalence of early-onset diabetes in particular raises clinical and societal concerns. Such individuals have a longer life-time disease duration and potentially can develop more diabetes related complications, at a relatively young age, perhaps during the most productive periods of their lives. The determinants of, and impact on outcome of age of onset as a clinical variable are unclear. Therefo

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18

Hartman, Mikael. "Risk and prognosis of breast cancer among women at high risk of the disease /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-303-0/.

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19

Bloomstrand, Mollie Anne. "An analysis of learning and memory in two aged chimpanzees." Thesis, Georgia Institute of Technology, 1985. http://hdl.handle.net/1853/28573.

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20

Cayo, Quiñe Alexandra, Valeria Martínez-Vargas, and Rossi Bustamante-Voysest. "Uso incorrecto de inhaladores de dosis medida en pacientes adultos de un hospital de Callao, Perú, 2014: estudio transversal." Medwave Estudios Limitada, 2015. http://hdl.handle.net/10757/579698.

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BACKGROUND Inhalation therapy has proven to be the best way to control the asthma and chronic obstructive pulmonary disease symptoms. The most commonly used delivery system to control these symptoms is the metered-dose inhaler. The primary goal of this study is to demonstrate an association between incorrect inhaler use and patient age. METHODS This is a cross-sectional study, performed at Centro Médico Naval “Cirujano Mayor Santiago Távara”, in Callao, Peru, in 2014. Patients older than 18 years that used metered-dose inhalers were included. We used film recordings of patients using a

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21

Schölvinck, Elisabeth Henriëtte. "The influence of age on the cellular immune response in patients with tuberculosis and healthy controls." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/53126.

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Thesis (PhD) -- Stellenbosch University, 2002.<br>ENGLISH ABSTRACT: Children and adults may differ in their immune function. An adequate function of the individual's immune system is crucial to the risk for development of tuberculosis (TB) after infection with Mycobacterium tuberculosis (Mtb). Epidemiological evidence suggests an age-related incidence of TB. Furthermore, the prevailing clinical expression t ' of TB varies between age groups. -The aims of this study were to characterise the cellular immune response at different ages in TB patients and healthy individuals living in a reg

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22

Eriksson-Berg, Margita. "Hemostasis in middle-aged women with coronary heart disease /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-978-1/.

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23

Bradley, Declan Terrance. "Genome-wide and complement system risk factors for abdominal aortic aneurysm, age-related macular degeneration and invasive meningococcal disease." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600124.

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Abdominal aortic aneurysm (AAA), age-related macular degeneration (AMO) and invasive meningococcal disease (IMO) are multifactorial diseases which have genetic and environmental risk factors. The complement system is an ancient part of the innate immune system that is activated in all three of these diseases. AAA is a pathological dilatation of the abdominal aorta that can rupture, often causing death. AMD is a common sight-impairing inflammatory retinal disease. IMD is due to infection with Neisseria meningilidis, which can cause potentially fatal illness in some people. The aim of this work

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24

Murugasen, Serini. "Age at menarche and menopause : their correlates and association with selected cardiovascular disease risk factors among 300,000 Chinese women in the China Kadoorie Biobank." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:3e5b66b9-0782-47c3-89a2-d95400e11689.

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Background: Age-standardised mortality rates for cardiovascular disease (CVD) are generally higher among men than women, prompting suggestions that reproductive factors may be partly responsible. Moreover, there have been major changes in women’s reproductive patterns and CVD rates in China over the last few decades, but the association between them is still poorly understood. Objectives: To start addressing these issues, this thesis examines the secular trends and correlates of age at menarche and menopause (the major physiological events defining a woman’s reproductive window), as well as th

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25

Wong, Chun-yam Fanny, and 黃峻崟. "Is secondhand smoking related to stroke in old age in Hong Kong?" Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39724633.

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26

Anderson, Ericka Lisle Barakat Lamia. "A prospective examination of neuropsychological functioning in preschool-age children with sickle cell disease and its association with psychosocial factors /." Philadelphia, Pa. : Drexel University, 2005. http://dspace.library.drexel.edu/handle/1860/610.

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27

Thomas, Aleysha. "Ensemble statistical modelling of risk factors in health." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/120675/1/Aleysha_Thomas_Thesis.pdf.

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This thesis aims to identify and characterise the combined effects of non-genetic risk factors, particularly quantitative measurements of organochlorine pesticide (OCP) exposure, on the age at Parkinson's Disease onset using an ensemble modelling approach with linear models, decision trees, hierarchical models, meta-analyses and Bayesian networks when only disparate data sources are available, and it is expensive and time-consuming to coordinate large-scale studies. Although the results of the analysis are not conclusive due to the nature of the data sources, our results justify further study

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28

So, Hon-fai, and 蘇漢暉. "Age-dependent effects of mitochondrial function in skin fibroblasts and skeletal muscle derived from a Parkinsonian LRRK2 R1441G knockinmouse model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50162846.

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Parkinson's disease (PD) is an age-related neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra of the brain. The pathogenesis and etiology of PD are unclear. Mitochondrial dysfunction occurs in PD, causing a decrease in complex I activity in postmortem brain, and exacerbating reactive oxygen species production and ATP deficiency contributing to neuronal cell death. Mutation of leucine-rich-repeat kinase 2 (LRRK2) gene is the most common genetic factor identified in both familial and sporadic PD cases. Several mutations in LRRK2 have be

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29

Williams, M. A. "Alzheimer's disease and age-related macular-degeneration : is complement factor H a common denominator?" Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546431.

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30

Alexander, Claire M. "Risk Factors for Alzheimer's Disease: Examination of the Effects of Traumatic Brain Injury and Apolipoprotein E." Ohio University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1610371643413149.

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31

Sofat, R. "Is complement factor H a shared risk factor for age-related macular degeneration and cardiovascular disease?" Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1331906/.

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Background and Aims: Inflammation is implicated in common disorders of ageing including atherosclerosis and age-related macular degeneration (AMD), although the link between inflammation and cardiovascular disease (CVD) is the more studied. The recent finding that susceptibility to AMD is increased substantially by common single nucleotide polymorphisms (SNPs) in the gene that encodes complement factor H (CFH; a circulating inhibitor of complement activation) provides evidence that inflammation in general, and complement in particular, maybe causally involved in AMD. Since AMD and atherosclero

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32

Sporik, Richard Bernard. "The natural history of allergic diseases in children : a prospective clinical, immunological and environmental study." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295805.

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33

Pringle, Nadine Alex. "Characterization of a glycated gelatin model to explore the therapeutic properties of macrofungi in diabetic wound healing: an in vitro study." Thesis, Nelson Mandela Metropolitan University, 2017. http://hdl.handle.net/10948/11992.

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Diabetic wounds frequently undergo impaired and prolonged wound healing due to a multitude of factors including hypoxia, impaired angiogenesis, hyperglycaemia, formation of ROS and AGEs, and infection - all of which may lead to cellular dysfunction. To date, however, treatment options for individuals suffering from impaired diabetic wound healing are limited, non-specific, and generally unsuccessful. The search for new and effective treatment strategies is severely hampered by the availability of adequately characterized screening models which comprehensively mimic the complexity of the diabet

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34

Young, Seth Allen. "Selected risk factors associated with failure to receive immunizations in an age-appropriate manner /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487262825075109.

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35

Cornett, Patricia F. "Factors of the Geriatric Depression Scale that may Distinguish between Four Cognitive Diagnostic Groups: Normal, Mild Cognitive Impairment, Dementia of the Alzheimer's Type, and Vascular Dementia." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc12105/.

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The purpose of the current study was to explore the relationship between cognitive status and depression in a sample of geriatric patients. Participants included 282 geriatric patients ranging in age from 65 to 96 years who were classified according to diagnosis as: DAT, VaD, MCI, and Norm. All were referred for neurocognitive testing from the Geriatric Assessment Program (GAP) at the University of North Texas Health Science Center (UNTHSC) in Fort Worth, Texas. This study sought to identify factor structures for two versions of the GDS using a geriatric sample of cognitively impaired and inta

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36

Carlson, Linda E. "Steroid hormones and memory in healthy elderly men, in women estrogen-users and non-users and in patients with Alzheimer's disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0021/NQ44379.pdf.

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37

Navér, Lars. "Perinatal HIV-1 infection : aspects on clinical presentation, viral dynamics and epidemiology /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-983-8/.

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38

Kampen, Diane L. "The relationship between estrogen and memory in healthy postmenopausal women and women in the early stages of Alzheimer's disease." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41108.

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The effects of exogenous estrogen administration on aspects of memory and cognition in women were examined in two studies. In Study 1, women receiving estrogen replacement therapy were compared to untreated women on four measures of verbal memory. Those receiving estrogen had significantly better scores on a measure of delayed memory for propositional material. In Study 2, women in the early stages of Alzheimer's Disease (AD) were administered either estrogen or placebo on a double-blind basis for six months. Women given estrogen showed improvement on a measure of verbal memory and spatial att

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39

Clausson, Britt. "Risk factors and adverse pregnancy outcomes in small-for-gestational-age births." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2000. http://publications.uu.se/theses/91-554-4858-5/.

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40

Eriksson, Margaretha. "The Impact of Birth Weight on Cardiovascular Risk Factors, Coronary Heart Disease and Prostate Cancer : Population-based Studies of Men Born in 1913 and Followed up Until Old Age." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6005.

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41

Ongore, Dismas. "Risk factors for infection and disease with the malaria parasite in children less than five years of age in Kisumu District Nyanza Province Kenya." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385095.

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42

Somana, Svay Sirikul Isaranurug. "Factors associated with the occurrence of acute respiratory infections in children from six months to five years of age in Tapraya hospital, Tapraya district (Sakeo province) /." Abstract, 2004. http://mulinet3.li.mahidol.ac.th/thesis/2547/cd363/4637941.pdf.

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43

GUTHERY, STEPHEN L. "PRIMARY IMMUNOSUPPRESSION WITH TACROLIMUS AND AGE AT TRANSPLANTATION AS INDEPENDENT RISK FACTORS FOR THE DEVELOPMENT OF POST-TRANSPLANT LYMPHOPROLIFERATIVE DISEASE IN CHILDREN UNDERGOING LIVER TRANSPLANTATION." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1016565901.

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44

Compte, Nathalie. "Impact of clinical factors on inflammaging and Toll-like receptors responses in old age." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209155.

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Le vieillissement s’accompagne d’une altération globale des fonctions physiologiques notamment celles de l’immunité :on parle « d’immunosénescence ». Ce processus se traduit entre autre par l’installation d’un état inflammatoire chronique caractérisé par une augmentation des taux sériques de cytokines telles que l’interleukine(IL)-6 et des protéines de la phase aigüe. Cet état proinflammatoire serait incriminé dans le déclin des fonctions physiologiques, la fragilité et les syndromes gériatriques. Par ailleurs, les maladies cardiovasculaires, la dépression et l’infection chronique par le Cytom

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45

Barker, Glenn A. "Carbohydrate metabolism in peripheral arterial disease." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/36790/1/36790_Digitised%20Thesis.pdf.

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Peripheral arterial disease results in varying degrees of functional disability. Although principally a disease of the vascular tree, evidence demonstrates a significant contribution from metabolic alterations within ischaemically affected skeletal muscle. This thesis was concerned with better characterising the nature of these metabolic alterations, and their contribution to the functional disability in PAD patients. It also examined the efficacy of dietary carbohydrate supplementation as a therapeutic intervention in PAD. The activity of the pyruvate dehydrogenase complex (PDH) is an impo

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46

Chigogora, Sungano. "Behavioural and biological predictors of depression in older age : the role of Internet use, insulin-like growth factor 1, and cardiovascular disease risk factors in the English Longitudinal Study of Ageing." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10046397/.

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BACKGROUND: Depression is a leading cause of disability and morbidity. Its determinants are not fully understood. In the present thesis I investigated the potential role of selected behavioural and biological characteristics in predicting depression in older people: Insulin-like Growth Factor 1 (IGF-1), Internet use and cardiovascular disease (CVD) risk factors. METHODS: Participants were recruited from the English Longitudinal Study of Ageing, an ongoing prospective cohort study of adults aged 50 years and over which was established in 2002. With six waves of biennial data collection up to 20

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47

Yu, Elizabeth A. "Investigating Age-Dependent Arthropathy in a Circadian Mutant Mouse Model: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/544.

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Ectopic calcification can cause pain and limit mobility. Studies suggest that circadian genes may play a role in the calcification process. Core circadian genes Clock, Npas2, and Bmal1 are transcription factors that form CLOCK:BMAL1 or NPAS2:BMAL1 transactivator complexes that drive the rhythmic expression of circadian oscillator genes and output genes. Circadian oscillator genes Period1-3 and Cryptochrome1-2 encode proteins that form transcription repressor complexes that feedback to inhibit CLOCK/NPAS2:BMAL1 activity, thus completing the feedback loop that is the basis of the molecular circa

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48

Mabasa, Matimba Allan. "The study of socio-cultural values and practices that influence the escalation of HIV and AIDS amongst the youth: a social work perspective." Thesis, University of Limpopo (Turfloop Campus), 2012. http://hdl.handle.net/10386/833.

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49

Ross, Amy Psychiatry Faculty of Medicine UNSW. "Longitudinal study of cognitive and functional brain changes in ageing and cerebrovascular disease, using proton magnetic resonance spectroscopy." Awarded by:University of New South Wales. School of Psychiatry, 2005. http://handle.unsw.edu.au/1959.4/27329.

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The neurophysiological basis of cognition changes with age is relatively unexplained, with most studies reporting weak relationships between cognition and measures of brain function, such as event related potentials, brain size and cerebral blood flow. Proton magnetic resonance spectroscopy (1H-MRS) is an in vivo method used to detect metabolites within the brain that are relevant to certain brain processes. Recent studies have shown that these metabolites, in particular N-acetyl aspartate (NAA), which is associated with neuronal viability, correlate with performance on neuropsychological test

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50

O'Donovan, James Gary. "Exercise, cardiorespiratory fitness and coronary heart disease risk factors in men aged 30-45 years." Thesis, University of Kent, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413274.

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