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Статті в журналах з теми "Bioenergetics":

1

Patón, Mauricio, and Jorge Rodríguez. "Integration of bioenergetics in the ADM1 and its impact on model predictions." Water Science and Technology 80, no. 2 (July 2019): 339–46. http://dx.doi.org/10.2166/wst.2019.279.

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Abstract In this work, the integration of dynamic bioenergetic calculations in the IWA Anaerobic Digestion Model No. 1 (ADM1) is presented. The impact of bioenergetics on kinetics was addressed via two different approaches: a thermodynamic-based inhibition function and variable microbial growth yields based on dynamic Gibbs free energy calculations. The dynamic bioenergetic calculations indicate that the standard ADM1 predicts positive reaction rates under thermodynamically unfeasible conditions. The dissolved hydrogen inhibition approach used in ADM1 is, however, deemed as adequate, offering the trade-off of not requiring dynamic bioenergetics computation despite the need of hydrogen inhibition parameters. Simulations of the model with bioenergetics showed the low amount of energy available in butyrate and propionate oxidation, suggesting that microbial growth on these substrates must be very limited or occur via alternative mechanisms rather than dissolved hydrogen.
2

Sandage, Mary J., and Audrey G. Smith. "Muscle Bioenergetic Considerations for Intrinsic Laryngeal Skeletal Muscle Physiology." Journal of Speech, Language, and Hearing Research 60, no. 5 (May 2017): 1254–63. http://dx.doi.org/10.1044/2016_jslhr-s-16-0192.

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PurposeIntrinsic laryngeal skeletal muscle bioenergetics, the means by which muscles produce fuel for muscle metabolism, is an understudied aspect of laryngeal physiology with direct implications for voice habilitation and rehabilitation. The purpose of this review is to describe bioenergetic pathways identified in limb skeletal muscle and introduce bioenergetic physiology as a necessary parameter for theoretical models of laryngeal skeletal muscle function.MethodA comprehensive review of the human intrinsic laryngeal skeletal muscle physiology literature was conducted. Findings regarding intrinsic laryngeal muscle fiber complement and muscle metabolism in human models are summarized and exercise physiology methodology is applied to identify probable bioenergetic pathways used for voice function.ResultsIntrinsic laryngeal skeletal muscle fibers described in human models support the fast, high-intensity physiological requirements of these muscles for biological functions of airway protection. Inclusion of muscle bioenergetic constructs in theoretical modeling of voice training, detraining, fatigue, and voice loading have been limited.ConclusionsMuscle bioenergetics, a key component for muscle training, detraining, and fatigue models in exercise science, is a little-considered aspect of intrinsic laryngeal skeletal muscle physiology. Partnered with knowledge of occupation-specific voice requirements, application of bioenergetics may inform novel considerations for voice habilitation and rehabilitation.
3

Coven, Arnold B. "The Bioenergetic Approach to Rehabilitation Counseling." Journal of Applied Rehabilitation Counseling 16, no. 2 (June 1985): 6–10. http://dx.doi.org/10.1891/0047-2220.16.2.6.

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The current focus on assisting the severely disabled confronts rehabilitation counselors with the demand of being more effective behavioral change agents. This article suggests that counselors try out Bioenergetics, a mindbody counseling approach. An overview of Bioenergetics theory is presented with examples of how it can be applied to the impaired. Guidelines for using Bioenergetic techniques are identified along with the necessary precautions.
4

Hill, Bradford G., Gloria A. Benavides, Jack R. Lancaster, Scott Ballinger, Lou Dell’Italia, Jianhua Zhang, and Victor M. Darley-Usmar. "Integration of cellular bioenergetics with mitochondrial quality control and autophagy." Biological Chemistry 393, no. 12 (December 2012): 1485–512. http://dx.doi.org/10.1515/hsz-2012-0198.

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Abstract Bioenergetic dysfunction is emerging as a cornerstone for establishing a framework for understanding the pathophysiology of cardiovascular disease, diabetes, cancer and neurodegeneration. Recent advances in cellular bioenergetics have shown that many cells maintain a substantial bioenergetic reserve capacity, which is a prospective index of ‘healthy’ mitochondrial populations. The bioenergetics of the cell are likely regulated by energy requirements and substrate availability. Additionally, the overall quality of the mitochondrial population and the relative abundance of mitochondria in cells and tissues also impinge on overall bioenergetic capacity and resistance to stress. Because mitochondria are susceptible to damage mediated by reactive oxygen/nitrogen and lipid species, maintaining a ‘healthy’ population of mitochondria through quality control mechanisms appears to be essential for cell survival under conditions of pathological stress. Accumulating evidence suggest that mitophagy is particularly important for preventing amplification of initial oxidative insults, which otherwise would further impair the respiratory chain or promote mutations in mitochondrial DNA (mtDNA). The processes underlying the regulation of mitophagy depend on several factors, including the integrity of mtDNA, electron transport chain activity, and the interaction and regulation of the autophagic machinery. The integration and interpretation of cellular bioenergetics in the context of mitochondrial quality control and genetics is the theme of this review.
5

Chacko, Balu K., Philip A. Kramer, Saranya Ravi, Gloria A. Benavides, Tanecia Mitchell, Brian P. Dranka, David Ferrick, et al. "The Bioenergetic Health Index: a new concept in mitochondrial translational research." Clinical Science 127, no. 6 (May 2014): 367–73. http://dx.doi.org/10.1042/cs20140101.

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Bioenergetics has become central to our understanding of pathological mechanisms, the development of new therapeutic strategies and as a biomarker for disease progression in neurodegeneration, diabetes, cancer and cardiovascular disease. A key concept is that the mitochondrion can act as the ‘canary in the coal mine’ by serving as an early warning of bioenergetic crisis in patient populations. We propose that new clinical tests to monitor changes in bioenergetics in patient populations are needed to take advantage of the early and sensitive ability of bioenergetics to determine severity and progression in complex and multifactorial diseases. With the recent development of high-throughput assays to measure cellular energetic function in the small number of cells that can be isolated from human blood these clinical tests are now feasible. We have shown that the sequential addition of well-characterized inhibitors of oxidative phosphorylation allows a bioenergetic profile to be measured in cells isolated from normal or pathological samples. From these data we propose that a single value–the Bioenergetic Health Index (BHI)–can be calculated to represent the patient's composite mitochondrial profile for a selected cell type. In the present Hypothesis paper, we discuss how BHI could serve as a dynamic index of bioenergetic health and how it can be measured in platelets and leucocytes. We propose that, ultimately, BHI has the potential to be a new biomarker for assessing patient health with both prognostic and diagnostic value.
6

Schroeter, Vincentia. "Integrating Regulation Therapy and Bioenergetic Analysis." Clinical Journal of the International Institute for Bioenergetic Analysis 24, no. 1 (March 2014): 105–32. http://dx.doi.org/10.30820/0743-4804-2014-24-105.

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Attachment theorists have recently become more interested in how bodily-based processes and interventions can contribute to their interest in the emotional regulation of arousal levels. A review of current concepts and techniques in integrative regulation therapy, including their value for Bioenergetics, will be examined. The literature of recent writings on attachment within Bioenergetics will be provided, along with a clinical vignette utilizing both approaches. The paper proposes that the Bioenergetic community answer the call to promote a somatic-energetic approach to the larger psychotherapeutic world.
7

Lehrer, H. Matthew, Lauren Chu, Martica Hall, and Kyle Murdock. "009 Self-Reported Sleep Efficiency and Duration are Associated with Systemic Bioenergetic Function in Community-Dwelling Adults." Sleep 44, Supplement_2 (May 2021): A4. http://dx.doi.org/10.1093/sleep/zsab072.008.

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Abstract Introduction Sleep is important for aging, health, and disease, but its cellular role in these outcomes is poorly understood. Basic research suggests that disturbed and insufficient sleep impair mitochondrial bioenergetics, which is involved in numerous aging-related chronic conditions. However, the relationship between sleep and bioenergetics has not been examined in humans. We examined associations of self-reported sleep with systemic bioenergetic function in peripheral blood mononuclear cells (PBMCs) of community-dwelling adults. Methods N = 43 adults (79% female) ages 48–70 (M = 61.63, SD = 5.99) completed the Pittsburgh Sleep Quality Index (PSQI) from which key components of sleep (satisfaction, alertness, timing, efficiency, and duration) were calculated. Participants provided blood samples from which PBMCs were isolated and measured for bioenergetics using extracellular flux analysis. Associations of sleep components with bioenergetic parameters, including the Bioenergetic Health Index (BHI), were examined. Results In bivariate analyses, lower sleep efficiency was associated with lower maximal respiration, spare capacity, and BHI (ps < 0.05). Longer sleep duration was associated with lower BHI (p < 0.01) and later sleep timing was associated with higher basal respiration, ATP-linked respiration, maximal respiration, spare capacity, and non-mitochondrial respiration (ps < 0.05). After adjustment for age, sex, and body mass index, lower sleep efficiency (β = 0.52, p < 0.01) and longer sleep duration (β = -0.43, p < 0.01) were associated with lower BHI. Conclusion Self-reported indices of sleep efficiency and duration are related to systemic bioenergetic function in humans, suggesting a possible cellular pathway linking sleep to health. Support (if any) T32HL082610
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Castillo, Rodrigo L., Emilio A. Herrera, Alejandro Gonzalez-Candia, Marjorie Reyes-Farias, Nicole de la Jara, Juan Pedro Peña, and Catalina Carrasco-Pozo. "Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats." Oxidative Medicine and Cellular Longevity 2018 (2018): 1–14. http://dx.doi.org/10.1155/2018/7239123.

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Alterations in cardiac energy metabolism play a key role in the pathogenesis of diabetic cardiomyopathy. Hypercholesterolemia associated with bioenergetic impairment and oxidative stress has not been well characterized in the cardiac function under glycemic control deficiency conditions. This work aimed to determine the cardioprotective effects of quercetin (QUE) against the damage induced by a high-cholesterol (HC) diet in hyperglycemic rats, addressing intracellular antioxidant mechanisms and bioenergetics. Quercetin reduced HC-induced alterations in the lipid profile and glycemia in rats. In addition, QUE attenuated cardiac diastolic dysfunction (increased E:A ratio), prevented cardiac cholesterol accumulation, and reduced the increase in HC-induced myocyte density. Moreover, QUE reduced HC-induced oxidative stress by preventing the decrease in GSH/GSSG ratio, Nrf2 nuclear translocation, HO-1 expression, and antioxidant enzymatic activity. Quercetin also counteracted HC-induced bioenergetic impairment, preventing a reduction in ATP levels and alterations in PGC-1α, UCP2, and PPARγ expression. In conclusion, the mechanisms that support the cardioprotective effect of QUE in rats with HC might be mediated by the upregulation of antioxidant mechanisms and improved bioenergetics on the heart. Targeting bioenergetics with QUE can be used as a pharmacological approach to modulate structural and functional changes of the heart under hypercholesterolemic and hyperglycemic conditions.
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Acin-Perez, Rebeca, Cristiane Benincá, Byourak Shabane, Orian S. Shirihai, and Linsey Stiles. "Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives." Life 11, no. 9 (September 2021): 949. http://dx.doi.org/10.3390/life11090949.

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Mitochondrial bioenergetic function is a central component of cellular metabolism in health and disease. Mitochondrial oxidative phosphorylation is critical for maintaining energetic homeostasis, and impairment of mitochondrial function underlies the development and progression of metabolic diseases and aging. However, measurement of mitochondrial bioenergetic function can be challenging in human samples due to limitations in the size of the collected sample. Furthermore, the collection of samples from human cohorts is often spread over multiple days and locations, which makes immediate sample processing and bioenergetics analysis challenging. Therefore, sample selection and choice of tests should be carefully considered. Basic research, clinical trials, and mitochondrial disease diagnosis rely primarily on skeletal muscle samples. However, obtaining skeletal muscle biopsies requires an appropriate clinical setting and specialized personnel, making skeletal muscle a less suitable tissue for certain research studies. Circulating white blood cells and platelets offer a promising primary tissue alternative to biopsies for the study of mitochondrial bioenergetics. Recent advances in frozen respirometry protocols combined with the utilization of minimally invasive and non-invasive samples may provide promise for future mitochondrial research studies in humans. Here we review the human samples commonly used for the measurement of mitochondrial bioenergetics with a focus on the advantages and limitations of each sample.
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Cha, Yong-Mei, Petras P. Dzeja, Margaret M. Redfield, Win K. Shen, and Andre Terzic. "Bioenergetic protection of failing atrial and ventricular myocardium by vasopeptidase inhibitor omapatrilat." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 4 (April 2006): H1686—H1692. http://dx.doi.org/10.1152/ajpheart.00384.2005.

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Deficient bioenergetic signaling contributes to myocardial dysfunction and electrical instability in both atrial and ventricular cardiac chambers. Yet, approaches capable to prevent metabolic distress are only partially established. Here, in a canine model of tachycardia-induced congestive heart failure, we compared atrial and ventricular bioenergetics and tested the efficacy of metabolic rescue with the vasopeptidase inhibitor omapatrilat. Despite intrinsic differences in energy metabolism, failing atria and ventricles demonstrated profound bioenergetic deficiency with reduced ATP and creatine phosphate levels and compromised adenylate kinase and creatine kinase catalysis. Depressed phosphotransfer enzyme activities correlated with reduced tissue ATP levels, whereas creatine phosphate inversely related with atrial and ventricular load. Chronic treatment with omapatrilat maintained myocardial ATP, the high-energy currency, and protected adenylate and creatine kinase phosphotransfer capacity. Omapatrilat-induced bioenergetic protection was associated with maintained atrial and ventricular structural integrity, albeit without full recovery of the creatine phosphate pool. Thus therapy with omapatrilat demonstrates the benefit in protecting phosphotransfer enzyme activities and in preventing impairment of atrial and ventricular bioenergetics in heart failure.

Дисертації з теми "Bioenergetics":

1

Spickett, Corinne Michelle. "NMR studies of cellular bioenergetics." Electronic Thesis or Diss., University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257961.

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Trudel, Marc. "Bioenergetics and mercury dynamics in fish." Electronic Thesis or Diss., McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36723.

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This research focuses on the development, evaluation, and application of a mercury (Hg) mass balance model for predicting the accumulation of Hg in fish. This model requires accurate estimates of Hg elimination rate by fish and feeding rates to adequately predict Hg concentration in fish. An empirical model was developed to estimate Hg elimination by fish using data obtained from published experiments. This analysis showed that Hg elimination rate was overestimated in short-term experiments, positively correlated to water temperature, negatively correlated to body size, and that the elimination rate of inorganic Hg was faster than that of methylmercury. This empirical model was then incorporated in a Hg mass balance model to predict the concentration of Hg in fish. The Hg mass balance model accurately predicted Hg concentration in fish when it was combined with food consumption rates that were determined using a radioisotopic method. This analysis suggested that the parameters of the Hg mass balance model were adequate for predicting Hg concentration in fish. I also showed that Hg concentration tended to be underestimated by the Hg mass balance model when it was combined with feeding rates determined with a laboratory-derived bioenergetic model, probably because activity costs derived in the laboratory do not reflect activity costs of fish in the field. Beside predicting Hg concentration in fish, I showed that this mass balance model could also be used to estimate feeding rates of fish in the field by measuring the concentration of Hg in fish. This approach was validated using data obtained from a published experiment. It was also successfully tested using independent estimates of feeding rates obtained with a radioisotopic method. I applied this Hg mass balance model to compare the energy budget of sympatric populations of dwarf and normal whitefish (Coregonus clupeaformis). This analysis showed that dwarf whitefish consumed 40--50% more food than normal whitefi
3

Trudel, Marc. "Bioenergetics and mercury dynamics in fish." Electronic thesis or diss., National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0035/NQ64684.pdf.

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4

Hinsley, Shelley Ann. "Bioenergetics of desert birds (Sandgrouse : Peteroclididae)." Electronic Thesis or Diss., Cardiff University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316237.

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5

Smolkova, Katarina. "Non-canonical bioenergetics of the cell." Electronic Thesis or Diss., Bordeaux 2, 2009. http://www.theses.fr/2009BOR21700/document.

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Non-canonical bioenergetics concerns with those physiological and pathophysiological situations under which ATP synthesis is suppressed. This thesis brings an outcome of three types of studies within the field of the non-canonical bioenergetics, investigating specific bioenergetic phenotypes of cancer cells, on one hand; and a role of mitochondrial uncoupling proteins as deduced from their transcript distribution in various tissues and organs; plus a role of a novel and likely pro-apoptotic factor CIDEa in mitochondria. Cancer cells generally present abnormal bioenergetic properties including an elevated glucose uptake, a high glycolysis and a poorly efficient oxidative phosphorylation system. However, the determinants of cancer cells metabolic reprogramming remain unknown. The main question in this project was how environmental conditions in vivo can influence functioning of mitochondrial OXPHOS, because details of mitochondrial bioenergetics of cancer cells is poorly documented. We have combined two conditions, namely glucose and oxygen deprivation, to measure their potential interaction. We examined the impact of glucose deprivation and oxygen deprivation on cell survival, overall bioenergetics and OXPHOS protein expression. As a model, we have chosen a human breast carcinoma (HTB-126) and appropriate control (HTB-125) cultured cells, as large fraction of breast malignancies exhibit hypoxic tumor regions with low oxygen concentrations and poor glucose delivery. The results demonstrate that glucose presence or absence largely influence functioning of mitochochondrial oxidative phosphorylation. The level of mitochondrial respiration capacity is regulated by glucose; by Crabtree effect, by energy substrate channeling towards anabolic pathways that support cell growth and by mitochondrial biogenesis pathways. Both oxygen deprivation and glucose deprivation can remodel the OXPHOS system, albeit in opposite directions. As an adaptative response to hypoxia, glucose inhibits mitochondrial oxidative phosphorylation to the larger extent than in normoxia. We concluded that the energy profile of cancer cells can be determined by specific balance between two main environmental stresses, glucose and oxygen deprivation. Thus, variability of intratumoral environment might explain the variability of cancer cells´ bioenergetic profile. Mitochondrial uncoupling proteins are proteins of inner mitochondrial membrane that uncouple respiration from ATP synthesis by their protonophoric activity. Originally determined tissue distribution seems to be invalid, since novel findings show that UCP1 is not restricted exclusively to brown fat and that originally considered brain-specific isoforms UCP4 and UCP5 might have wider tissue distribution. Hence, in second part of this thesis, I discuss consequences of findings of UCPn transcripts in the studied mouse and rat tissues. We have shown that mRNA of UCPn varies up to four orders of magnitude in rat and mouse tissues with highest expression in rat spleen, rat and mouse lung, and rat heart. Levels of the same order of magnitude were found for UCP3 mRNA in rat 100 and mouse skeletal muscle, for UCP4 and UCP5 mRNA in mouse brain, and for UCP2 and UCP5 mRNA in mouse white adipose tissue. Further, we have shown that expression pattern of UCPn varies between animal species, rat versus mouse, such as the dominance of UCP3/UCP5 vs. UCP2 transcript in mouse heart and vice versa in rat heart; or UCP2 (UCP5) dominance in rat brain contrary to 10-fold higher UCP4 and UCP5 dominance in mouse brain. spontaneous apoptosis due to CIDEa overexpression in HeLa cells, adapted for a tetracycline-inducible CIDEa expression, a portion of mitochondria-localized CIDEa molecules migrates to cytosol or nucleus
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6

Roach, Ty Noble Frederick. "Nonequilibrium Thermodynamics, Microbial Bioenergetics, and Community Ecology." Thesis, University of California, San Diego, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=10827422.

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While it is clear that thermodynamics plays a nontrivial role in biological processes, exactly how this affects the macroscopic structuring of living systems is not fully understood. Thus, the objective of this dissertation was to investigate how thermodynamic variables such as exergy, entropy, and information are involved in biological processes such as cellular metabolism, ecological succession, and evolution. To this end, I have used a combination of mathematical modelling, in silico simulation, and both laboratory- and field-based experimentation.

To begin the dissertation, I review the basic tenets of biological thermodynamics and synthesize them with modern fluctuation theory, information theory, and finite time thermodynamics. In this review, I develop hypotheses concerning how entropy production rate changes across various time scales and exergy inputs. To begin testing these hypotheses I utilized a stochastic, agent-based, mathematical model of ecological evolution, The Tangled Nature Model. This model allows one to observe the dynamics of entropy production over time scales that would not be possible in real biological systems (i.e., 106 generations). The results of the model’s simulations demonstrate that the ecological communities generated by the model’s dynamics have increasing entropies, and that this leads to emergent order, organization, and complexity over time. To continue to examine the role of thermodynamics in biological processes I investigated the bioenergetics of marine microbes associated with benthic substrates on coral reefs. By utilizing both mesocosm and in situ experiments I have shown that these microbes change their power output, oxygen uptake, and community structure depending upon their available exergy.

Overall, the data presented herein demonstrates that ecological structuring and evolutionary change are, at least in part, determined by underlying thermodynamic mechanisms. Recognizing how physical processes affect biological dynamics allows for a more holistic understanding of biology at all scales from biochemistry, to ecological succession, and even long-term evolutionary change.

7

Li, Zhaoqi Ph D. Massachusetts Institute of Technology. "Bioenergetics and metabolism of eukaryotic cell proliferation." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/130658.

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Thesis: Ph. D. in Biochemistry, Massachusetts Institute of Technology, Department of Biology, February, 2021
Cataloged from the official PDF of thesis. "February 2021." Vita. Page 179 blank.
Includes bibliographical references.
Cellular growth and proliferation necessitates the transformation of cell-external nutrients into biomass. Strategies of biomass accumulation across the kingdoms of life are diverse and range from carbon fixation by autotrophic organisms to direct biomass incorporation of consumed nutrients by heterotrophic organisms. The goal of this dissertation is to better understand the divergent and convergent modes of metabolism that support biomass accumulation and proliferation in eukaryotic cells. We first determined that the underlying mechanism behind why rapidly proliferating cells preferentially ferment the terminal glycolytic product pyruvate is due to an intrinsic deficiency of respiration to regenerate electron acceptors. We tested this model across an assorted array of proliferating cells and organisms ranging from human cancer cells to the baker's yeast Saccharomyces cerevesiae. We next determined that a major metabolic pathway of avid electron acceptor consumption in the context of biomass accumulation is the synthesis of lipids. Insights from this work has led to the realization that net-reductive pathways such as lipid synthesis may be rate-limited by oxidative reactions. Lastly, we established the green algae Chlorella vulgaris as a model system to study the comparative metabolism of photoautotrophic and heterotrophic growth. We determined that heterotrophic growth of plant cells is associated with aerobic glycolysis in a mechanism that may be suppressed by light. Collectively, these studies contribute to a more holistic understanding of the bioenergetics and metabolic pathways employed by eukaryotic cells to accumulate biomass and lay the foundation for future studies to understand proliferative metabolism.
by Zhaoqi Li.
Ph. D. in Biochemistry
Ph.D.inBiochemistry Massachusetts Institute of Technology, Department of Biology
8

Ferng, Alice Shirong. "Cardiac Organogenesis: 3D Bioscaffolds, Bioenergetics and Regeneration." Electronic Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/596090.

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Each year the Organ Procurement and Transplantation Network (OPTN) reports an increase in patients requiring an organ transplant without an increase in available donor organs, leading to a transplant gap that continues to widen. Over 70% of donor hearts are deemed unsuitable for transplantation each year, and a large number of these organs (~50%) are discarded due to poor organ function, decreased ejection fraction, disease, or cardiac arrest (Scientific Registry of Transplant Recipients (SRTR) Annual Data Report 2011).We therefore set out to improve knowledge in the field of cardiac transplantation in terms of organogenesis, bioenergetics, and regeneration. The main goal through tissue bioengineering is to regenerate and salvage discarded hearts through organogenesis, or to lengthen the total organ preservation time such that organs would not be thrown away while a recipient was waiting to be found. Our first hypothesis was that an optimized acellular extracellular matrix scaffold would allow for cell adherence, growth and proliferation, and could potentially be grown into a clinically transplantable organ. To achieve these goals, an optimized protocol was developed for the total acellularization of a whole porcine heart, leaving behind a 3D bioscaffold. We showed that acellularized matrices could be successfully seeded using endothelial cells for acellular vasculature and stem cells for other acellular tissues, both as a 2D matrix and within a constantly perfused 3D Langendorff setup bioreactor. In order to best understand cell-cell and cell-matrix interactions, cellular bioenergetics were evaluated. We hypothesized that the bioenergetic demand of the type and anatomical origin of stem cells would affect the regeneration potential dependent on intrinsic metabolic demand. We therefore showed a differential of the bioenergetic profiles of human adipose-derived stem cells isolated from various adipose depots, concluding that the physiological microenvironment that supports stem cells in specific anatomic locations can regulate how stem cells participate in tissue regeneration, maintenance and repair, and also will vary based on donor-differences. During organ transplantation, organ preservation solutions are created for use at specific conditions, such as on ice or at room temperature. We hypothesized that hypothermia would slow down cellular metabolism, and that solutions containing a higher content of antioxidants and other protective substrates against ischemic reperfusion injury would create the best organ storage conditions. We tested three organ preservation solutions against control media and normal saline at 4 and 21 degrees C, for 4 to 8 hours, investigating the bioenergetics of organ preservation solution effects on cardiac cells. By simulating clinical conditions, we were able to determine that one of our solutions was ideal and had protective effects for cells for up to 8 hours at 4 degrees C. Finally, we believed that studying existing cardiac patches and optimizing cardiac matrix design would lead to improved cardiac physiological function and would aid in healing and repair during cardiac surgery. Following a clinical case report showing new cardiac tissue growth after implantation of an acellular porcine extracellular matrix, we devised a proof-of-concept study to show that clinical matrices could be easily cultured in vitro. We successfully seeded these clinical matrices using human amniotic stem cells, a commonly used cell type for regeneration and repair after surgery. Our preliminary studies suggest that preconditioned matrices can be potentially used clinically for greater efficacy and tissue regeneration.
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Hislop, Michael Stuart. "The effect of anabolic-androgenic hormones on postprandial triglyceridaemia and lipoprotein profiles in man." Master Thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/26978.

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It has been hypothesised that endogenous testosterone and AAS may predispose humans to premature CHD. However, there is no direct evidence to link these hormones with a greater prevalence of premature CHD. The aim of this thesis was to better describe atherosclerotic risk associated with these hormones by clarifying their effect on additional risk factors for premature atherosclerosis. Little is known about the effect of testosterone and AAS on 'atherogenic dyslipidaemia', a phenotype characterised by elevated postprandial triglyceridaemia, small dense LDL and a low HDLC concentration, which confers a high risk of CHD. Accordingly, the magnitude of postprandial triglyceridaemia, LDL and HDL particle size, and LDLC, HDLC and Lp(a) concentration were compared in male (n=9) and female (n=3) bodybuilders after self administration of AAS for 5-6 weeks (ON cycle) and again after a 4-6 week 'washout' period (OFF cycle), and in normal males (T) (n=10) before and during a reversible suppression of endogenous testosterone, induced using a GnRH agonist (triptorelin), and in a control group (C) (n=8). Lipoprotein size was assessed by gradient gel electrophoresis (GGE), lipoprotein concentrations by immuno and enzymatic assay, and postprandial triglyceridaemia by a standardised oral fat tolerance test (65g/m² ). HDLC decreased in male bodybuilders (0.94±0.30 vs 0.70±0.27 mmol/L, p=0.004; x ± SD) and female bodybuilders (1.3±0.5 vs 0.8±0.2 mmol/L) ON cycle. GGE studies suggested that mostly HDL₂ was reduced. There were no significant reductions in LDL particle size ON cycle. Two males had larger LDL species ON cycle. Lp(a) decreased in male bodybuilders (124.7±128.0 to 69.3±73.3 U/L, p=0.008). ON cycle postprandial triglyceride excursion was unchanged in female bodybuilders and reduced (11.6±10.0 vs 7.5±5.4 mmol/L.hr; p=0.027) in male bodybuilders. In the triptorelin study, HDLC was increased in T (1.07±0.18 vs 1.41±0.28 mmol/L, p=0.002) and not in C. GGE studies indicated an increase of HDL₂ in five T subjects and no increase in C. Total cholesterol increased in T (4.77±0.80 vs 5.24±1.04 mmol/L, p=0.039) but not in C. LDL size increased in four T subjects, and not in C. Lp(a) increased in T (277.9±149.l vs 376.5±222.2 U/L, p=0.004), but not in C. Postprandial triglyceridaemia was unchanged in both T and C. The results of these studies did not show any additional atherogenic effects of endogenous testosterone or AAS in humans. Rather, a suppression of Lp(a) may be an antiatherogenic effect of these hormones. A reduced postprandial triglyceridaemia and increased LDL size in individuals who are predisposed to 'atherogenic dyslipidaemia', may be further antiatherogenic effects of AAS use.
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Krohn, Martha M. "Growth and bioenergetics of northern cod (Gadus morhua)." Electronic thesis or diss., National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ49272.pdf.

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Книги з теми "Bioenergetics":

1

Lowen, Alexander. Bioenergetics. New York: Penguin/Arkana, 1994.

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Clark, Kevin B. Bioenergetics. Rijeka, Croatia: InTech, 2012.

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Kim, Chong H., and Takayuki Ozawa, eds. Bioenergetics. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-5835-0.

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Schäfer, Günter, and Harvey S. Penefsky, eds. Bioenergetics. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-78622-1.

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Gräber, Peter, Giulio Milazzo, and Dieter Walz, eds. Bioenergetics. Basel: Birkhäuser Basel, 1997. http://dx.doi.org/10.1007/978-3-0348-8994-0.

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Berkin, Jeffrey W. Bioenergetics. Hauppauge, N.Y: Nova Science Publishers, 2010.

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7

Jobling, Malcolm. Fish bioenergetics. London: Chapman and Hall, 1994.

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8

Nicholls, David G. Bioenergetics 2. London: Academic Press, 1992.

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9

Palmeira, Carlos M., and António J. Moreno, eds. Mitochondrial Bioenergetics. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-382-0.

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Skulachev, Vladimir P. Membrane Bioenergetics. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-72978-2.

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Частини книг з теми "Bioenergetics":

1

Moghaddam, Masoud. "Bioenergetics." In Coaching for Sports Performance, 240–64. First Edition. | New York : Routledge, 2019. |: Routledge, 2019. http://dx.doi.org/10.4324/9780429299360-8.

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Esteban, Genoveva F., and Tom M. Fenchel. "Bioenergetics." In Ecology of Protozoa, 55–62. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-59979-9_5.

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Hill, Keith, Tom Baranowski, Walter Schmidt, Nicole Prommer, Michel Audran, Philippe Connes, Ramiro L. Gutiérrez, et al. "Bioenergetics." In Encyclopedia of Exercise Medicine in Health and Disease, 118. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_4080.

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Chandler, T. Jeff, W. Britt Chandler, and C. Eric Arnold. "Bioenergetics." In Conditioning for Strength and Human Performance, 2–21. Third edition. | New York, NY : Routledge, 2018.: Routledge, 2018. http://dx.doi.org/10.4324/9781315438450-2.

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Amils, Ricardo. "Bioenergetics." In Encyclopedia of Astrobiology, 270–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_746.

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Nederkoorn, Paul H. J., Henk Timmerman, and Gabriëlle M. Donné-Op den Kelder. "Bioenergetics." In Signal Transduction by G Protein-Coupled Receptors, 3–16. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4684-1407-3_1.

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Petty, Howard R. "Bioenergetics." In Molecular Biology of Membranes, 123–88. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-1146-9_5.

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Wootton, Robert J. "Bioenergetics." In Ecology of Teleost Fishes, 73–96. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0829-1_4.

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Stenesh, J. "Bioenergetics." In Biochemistry, 221–35. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4757-9427-4_9.

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Mehlhorn, Heinz. "Bioenergetics." In Encyclopedia of Parasitology, 327. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_404.

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Тези доповідей конференцій з теми "Bioenergetics":

1

Xu, Weiling, Suzy A. Comhair, Allison J. Janocha, Lori A. Mavrakis, and Serpil C. Erzurum. "Cellular Bioenergetics In Asthma." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2807.

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Simion, Gabriela. "BIOENERGETICS METHOD FOR BIOSYSTEMS TESTING." In 18th International Multidisciplinary Scientific GeoConference SGEM2018. Stef92 Technology, 2018. http://dx.doi.org/10.5593/sgem2018/5.1/s20.019.

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Filiou, M. "Stress and bioenergetics: what about mitochondria?" In Abstracts of the 30th Symposium of the AGNP. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1606411.

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Rezende, Maria Clara Lopes, Maria Luiza Franco de Oliveira, Júlia Campos Fabri, Maria Júlia Filgueiras Granato, Mariana Vanon Moreira, and Leandro Vespoli Campos. "Neuroprotective Effects of Creatine Supplementation in Neurodegenerative Diseases." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.234.

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Introduction: Creatine is important in providing energy for the resynthesis of adenosine triphosphate (ATP) and in the deposition of intracellular energy, being present mainly in muscle fibers and in the brain. Supplementation with exogenous creatine can be used in neurodegenerative disorders that are related to bioenergetic deficits in the etiology and progression of the disease. Objective: Highlight the neuroprotective mechanisms of creatine supplementation in neurodegenerative diseases. Methods: In April 2021, a search was carried out on MEDLINE, with the descriptors: “Creatine” and “Neuroprotection”; and its variations, obtained in MeSH. Studies published in the last five years were included. Results: Of the 122 articles found, four were used in this work. They concluded that creatine supplementation contributes to brain bioenergetics by increasing phosphocreatine deposits, restoring mitochondrial functions and decreasing susceptibility to apoptosis. In addition, creatine intake shortly after the diagnosis of Huntington’s and Parkinson’s Diseases can be used as a complementary therapy, because improve performance in tasks of memory and intelligence. Finally, it buffers cellular concentrations of ATP, being a possible therapeutic strategy to delay or stop neurodegeneration diseases. Conclusion: Creatine promote important neuroprotective effect, but further studies on the subject are needed.
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Escalona, Emilia, Marcelo Muñoz, Roxana Pincheira, Alvaro A. Elorza, and Ariel F. Castro. "Abstract B083: NUAK1 regulates breast cancer cell bioenergetics." In Abstracts: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; October 26-30, 2019; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-b083.

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Biniecka, Monika, Emese Balogh, Aisling Kennedy, Chin T. Ng, Douglas J. Veale, and Ursula Fearon. "04.20 Oxidative stress alters cellular bioenergetics in inflammatory arthritis." In 37th European Workshop for Rheumatology Research 2–4 March 2017 Athens, Greece. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2016-211051.20.

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7

Morgan Davis Hayes, Hongwei Xin, Hong Li, Timothy Shepherd, Yang Zhao, and John Paul Stinn. "Bioenergetics of Hy-Line Brown Hens in Aviary Houses." In 2012 IX International Livestock Environment Symposium (ILES IX). St. Joseph, MI: American Society of Agricultural and Biological Engineers, 2012. http://dx.doi.org/10.13031/2013.41576.

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Hauser, Gary E., John Stark, George Robbins, and Bethel Herrold. "Thermal and Bioenergetics Modeling for Balancing Energy and Environment." In Waterpower Conference 1999. Reston, VA: American Society of Civil Engineers, 1999. http://dx.doi.org/10.1061/40440(1999)49.

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Zhou, Y., T. Guo, S. Z. Yang, Y. Zhu, C. S. Jiang, and H. Peng. "Mitochondrial Fission and Bioenergetics Mediate Human Lung Fibroblast Durotaxis." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5224.

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Fuzella, Tatiana. "PROSPECTS OF USAGE OF BIOENERGETICS AT RURAL ECONOMY OF BULGARIA." In 13th SGEM GeoConference on ENERGY AND CLEAN TECHNOLOGIES. Stef92 Technology, 2013. http://dx.doi.org/10.5593/sgem2013/bd4/s17.023.

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Звіти організацій з теми "Bioenergetics":

1

Lanyi, Janos K., and Sergei Balashov. Bioenergetics of halophiles. Office of Scientific and Technical Information (OSTI), February 2016. http://dx.doi.org/10.2172/1239563.

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Packer, L. The bioenergetics of salt tolerance. Office of Scientific and Technical Information (OSTI), January 1991. http://dx.doi.org/10.2172/5141950.

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3

Trappe, Scott A. Scientific/Technical Report Bioenergetics Research Initiative Award number-DE-FG02-05ER64092. Office of Scientific and Technical Information (OSTI), December 2009. http://dx.doi.org/10.2172/968497.

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4

Spotila, J. R. Constraints of bioenergetics on the ecology and distribution of vertebrate ectotherms. Office of Scientific and Technical Information (OSTI), November 1992. http://dx.doi.org/10.2172/6658267.

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5

Rondorf, Dennis W. Bioenergetics of Juvenile Salmon During the Spring Outmigration, 1983 Annual Report. Office of Scientific and Technical Information (OSTI), July 1985. http://dx.doi.org/10.2172/5421371.

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Ludden, Paul W. The Biochemistry, Bioenergetics, and Physiology of CO-Dependent Growth of Rhodospirillum rubrum. Office of Scientific and Technical Information (OSTI), September 2005. http://dx.doi.org/10.2172/850014.

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Ludden, P. W., and G. P. Roberts. [The biochemistry, bioenergetics, and physiology of the CO-dependent growth of Rhodospirillum rubrum]. Office of Scientific and Technical Information (OSTI), January 1992. http://dx.doi.org/10.2172/7096789.

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Eggleton, Michael A., Steve Miranda, and James P. Kirk. Potential for Predation by Fishes to Impact Zebra Mussels Dreissena polymorpha: Insight from Bioenergetics Models. Fort Belvoir, VA: Defense Technical Information Center, December 2003. http://dx.doi.org/10.21236/ada422134.

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9

Wells, Vanessa. CE-QUAL-W2 Water Quality and Fish-bioenergetics Model of Chester Morse Lake and the Cedar River. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.324.

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10

Spotila, J. R. Constraints of bioenergetics on the ecology and distribution of vertebrate ectotherms. Final report, 1 September 1988--30 June 1990. Office of Scientific and Technical Information (OSTI), November 1992. http://dx.doi.org/10.2172/10140266.

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