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Статті в журналах з теми "Entry–exit function":

1

De Maesschalck, Peter, and Stephen Schecter. "The entry–exit function and geometric singular perturbation theory." Journal of Differential Equations 260, no. 8 (April 2016): 6697–715. http://dx.doi.org/10.1016/j.jde.2016.01.008.

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2

Hsu, Ting-Hao, and Shigui Ruan. "Relaxation Oscillations and the Entry-Exit Function in Multidimensional Slow-Fast Systems." SIAM Journal on Mathematical Analysis 53, no. 4 (January 2021): 3717–58. http://dx.doi.org/10.1137/19m1295507.

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3

Rossio, Valentina, and Satoshi Yoshida. "Spatial regulation of Cdc55–PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast." Journal of Cell Biology 193, no. 3 (May 2, 2011): 445–54. http://dx.doi.org/10.1083/jcb.201101134.

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Budding yeast CDC55 encodes a regulatory B subunit of the PP2A (protein phosphatase 2A), which plays important roles in mitotic entry and mitotic exit. The spatial and temporal regulation of PP2A is poorly understood, although recent studies demonstrated that the conserved proteins Zds1 and Zds2 stoichiometrically bind to Cdc55–PP2A and regulate it in a complex manner. Zds1/Zds2 promote Cdc55–PP2A function for mitotic entry, whereas Zds1/Zds2 inhibit Cdc55–PP2A function during mitotic exit. In this paper, we propose that Zds1/Zds2 primarily control Cdc55 localization. Cortical and cytoplasmic localization of Cdc55 requires Zds1/Zds2, and Cdc55 accumulates in the nucleus in the absence of Zds1/Zds2. By genetically manipulating the nucleocytoplasmic distribution of Cdc55, we showed that Cdc55 promotes mitotic entry when in the cytoplasm. On the other hand, nuclear Cdc55 prevents mitotic exit. Our analysis defines the long-sought molecular function for the zillion different screens family proteins and reveals the importance of the regulation of PP2A localization for proper mitotic progression.
4

Lin, Chin-Tsai, and Cheng-Ru Wu. "Build to order and entry/exit strategies under exchange rate uncertainty." Yugoslav Journal of Operations Research 14, no. 2 (2004): 193–208. http://dx.doi.org/10.2298/yjor0402193l.

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Under uncertainty of exchange rate, we extend the build to order production model of Lin et al. (2002) by considering the export-oriented manufacturer to make decisions to switch production location freely between domestic and foreign ones. The export-oriented manufacturer is risk neutral and has rational expectations. When we transfer the production location from domestic (foreign) to foreign (domestic), and the production location transferring cost and the drift of real exchange rate are both equal to zero, then the optimal entry and exit threshold value of Cobb-Douglas production function are equal, no matter whether we use real options or net present value method. Thus export-oriented manufacturer can make decisions at the optimal transfer threshold value for transferable locations wherever the production locations are. It provides the export-oriented manufacturer with another way of thinking.
5

Dao, Manh Khang. "Hamilton-Jacobi equations for optimal control on networks with entry or exit costs." ESAIM: Control, Optimisation and Calculus of Variations 25 (2019): 15. http://dx.doi.org/10.1051/cocv/2018003.

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We consider an optimal control on networks in the spirit of the works of Achdou et al. [NoDEA Nonlinear Differ. Equ. Appl. 20 (2013) 413–445] and Imbert et al. [ESAIM: COCV 19 (2013) 129–166]. The main new feature is that there are entry (or exit) costs at the edges of the network leading to a possible discontinuous value function. We characterize the value function as the unique viscosity solution of a new Hamilton-Jacobi system. The uniqueness is a consequence of a comparison principle for which we give two different proofs, one with arguments from the theory of optimal control inspired by Achdou et al. [ESAIM: COCV 21 (2015) 876–899] and one based on partial differential equations techniques inspired by a recent work of Lions and Souganidis [Atti Accad. Naz. Lincei Rend. Lincei Mat. Appl. 27 (2016) 535–545].
6

LIN, TYRONE T., CHUAN-CHUAN KO, and CHIEN-YU LIU. "AN OPTIMAL MARKET ENTRY/EXIT EVALUATION MODEL WITH PARTIAL FINANCING FUNDS." Asia-Pacific Journal of Operational Research 27, no. 02 (April 2010): 257–69. http://dx.doi.org/10.1142/s0217595910002673.

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The paper mainly aims to introduce the real options approach to construct an evaluation model for the firm value under partial financing funds. The paper examines that production volume follows the geometric Brownian motion and considers that both the market entry of investment cost and the market exit of withdrawal cost match the linear function with production volume. Then the paper evaluates the potential firm value before market entry, the operational value with the firm's operating, and the market exit value with the firm's stopping to operate so as to assess the whole firm value, shareholder value, and bondholder value hereafter. The results show that different debt ratios will affect the firm's investment decision. The paper figures out the optimal decision-making based on the maximum profit of shareholders or the maximum profit of shareholders-and-bondholders. The factor is finance leverage; although interest expenses are tax deductible, an overly high leverage may trigger agency costs for a firm, which will offset the tax shields associated with leverage. Therefore, a firm should not leverage too much. Furthermore, the paper constructs an innovative evaluation model in a dynamic-financing environment in order to provide the management team with a decision-making mechanism for their decisions in market entry or market exit in a timely manner in the face of uncontrollable exogenous variables.
7

Kudo, Hiroko. "Exit/Entry, Voice/Noise, and Loyalty/Apathy in the era of social media." Central and Eastern European eDem and eGov Days 338 (July 16, 2020): 417–29. http://dx.doi.org/10.24989/ocg.338.33.

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Use of Social Media in public life has changed the way how citizens relate to public sector. Modern communication tools, in particular Social Media, have made citizens easier to use their “voice” to mobilize. When citizens can easily mobilize, the cost of mobilization is low for them, while its impact can lead to a larger cost for the State. As the exit/entry cost of Social Media is very low or almost nothing, a virtual network has been substituting institutions, causing new issues to the State. This leads to the issue of loyalty: citizens now feel that they do not need institution like the State to belong to, as many networks substitute its function. This paper analyses the Social Media use by citizens and its impact on public sector through Albert Hirschman’s classis “Exit, Voice, and Loyalty” and tries to address new aspects.
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Reiser, Vladimír, Katharine E. D’Aquino, Ly-Sha Ee, and Angelika Amon. "The Stress-activated Mitogen-activated Protein Kinase Signaling Cascade Promotes Exit from Mitosis." Molecular Biology of the Cell 17, no. 7 (July 2006): 3136–46. http://dx.doi.org/10.1091/mbc.e05-12-1102.

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In budding yeast, a signaling network known as the mitotic exit network (MEN) triggers exit from mitosis. We find that hypertonic stress allows MEN mutants to exit from mitosis in a manner dependent on the high osmolarity glycerol (HOG) mitogen-activated protein (MAP) kinase cascade. The HOG pathway drives exit from mitosis in MEN mutants by promoting the activation of the MEN effector, the protein phosphatase Cdc14. Activation of Cdc14 depends on the Cdc14 early anaphase release network, a group of proteins that functions in parallel to the MEN to promote Cdc14 function. Notably, exit from mitosis is promoted by the signaling branch defined by the Sho1 osmosensing system, but not by the Sln1 osmosensor of the HOG pathway. Our results suggest that the stress MAP kinase pathway mobilizes programs to promote completion of the cell cycle and entry into G1 under unfavorable conditions.
9

Du, Ruikun, Qinghua Cui, and Lijun Rong. "Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry." Viruses 11, no. 5 (May 20, 2019): 458. http://dx.doi.org/10.3390/v11050458.

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The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA binds SA through its receptor-binding sites, while NA is a receptor-destroying enzyme by removing SAs. The function of HA during virus entry has been extensively investigated, however, examination of NA has long been focused to its role in the exit of progeny virus from infected cells, and the role of NA in the entry process is still under-appreciated. This review summarizes the current understanding of the roles of HA and NA in relation to each other during virus entry.
10

Moutinho-Pereira, Sara, Alain Debec, and Helder Maiato. "Microtubule Cytoskeleton Remodeling by Acentriolar Microtubule-organizing Centers at the Entry and Exit from Mitosis in Drosophila Somatic Cells." Molecular Biology of the Cell 20, no. 11 (June 2009): 2796–808. http://dx.doi.org/10.1091/mbc.e09-01-0011.

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Cytoskeleton microtubules undergo a reversible metamorphosis as cells enter and exit mitosis to build a transient mitotic spindle required for chromosome segregation. Centrosomes play a dominant but dispensable role in microtubule (MT) organization throughout the animal cell cycle, supporting the existence of concurrent mechanisms that remain unclear. Here we investigated MT organization at the entry and exit from mitosis, after perturbation of centriole function in Drosophila S2 cells. We found that several MTs originate from acentriolar microtubule-organizing centers (aMTOCs) that contain γ-tubulin and require Centrosomin (Cnn) for normal architecture and function. During spindle assembly, aMTOCs associated with peripheral MTs are recruited to acentriolar spindle poles by an Ncd/dynein-dependent clustering mechanism to form rudimentary aster-like structures. At anaphase onset, down-regulation of CDK1 triggers massive formation of cytoplasmic MTs de novo, many of which nucleated directly from aMTOCs. CDK1 down-regulation at anaphase coordinates the activity of Msps/XMAP215 and the kinesin-13 KLP10A to favor net MT growth and stability from aMTOCs. Finally, we show that microtubule nucleation from aMTOCs also occurs in cells containing centrosomes. Our data reveal a new form of cell cycle–regulated MTOCs that contribute for MT cytoskeleton remodeling during mitotic spindle assembly/disassembly in animal somatic cells, independently of centrioles.

Дисертації з теми "Entry–exit function":

1

Sensi, Mattia. "A Geometric Singular Perturbation approach to epidemic compartmental models." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/286191.

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We study fast-slow versions of the SIR, SIRS and SIRWS epidemiological models, and of the SIRS epidemiological model on homogeneous graphs, obtained through the application of the moment closure method. The multiple time scale behavior is introduced to account for large differences between some of the rates of the epidemiological pathways. Our main purpose is to show that the fast-slow models, even though in nonstandard form, can be studied by means of Geometric Singular Perturbation Theory (GSPT). In particular, without using Lyapunov's method, we are able to not only analyze the stability of the endemic equilibria of the SIR and SIRS models, but also to show that in the remaining models limit cycles arise. We show that the proposed approach is particularly useful in more complicated (higher dimensional) models such as the SIRWS model and the SIRS on homogeneous graphs, for which we provide a detailed description of their dynamics by combining analytic and numerical techniques. In particular, for the latter we show that the model can give rise to periodic solutions, differently from the corresponding model based on homogeneous mixing.
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Sensi, Mattia. "A Geometric Singular Perturbation approach to epidemic compartmental models." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/286191.

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We study fast-slow versions of the SIR, SIRS and SIRWS epidemiological models, and of the SIRS epidemiological model on homogeneous graphs, obtained through the application of the moment closure method. The multiple time scale behavior is introduced to account for large differences between some of the rates of the epidemiological pathways. Our main purpose is to show that the fast-slow models, even though in nonstandard form, can be studied by means of Geometric Singular Perturbation Theory (GSPT). In particular, without using Lyapunov's method, we are able to not only analyze the stability of the endemic equilibria of the SIR and SIRS models, but also to show that in the remaining models limit cycles arise. We show that the proposed approach is particularly useful in more complicated (higher dimensional) models such as the SIRWS model and the SIRS on homogeneous graphs, for which we provide a detailed description of their dynamics by combining analytic and numerical techniques. In particular, for the latter we show that the model can give rise to periodic solutions, differently from the corresponding model based on homogeneous mixing.
3

Gurell, Ann. "Biochemical Studies on a Plant Epoxide Hydrolase : Discovery of a Proton Entry and Exit Pathway and the Use of In vitro Evolution to Shift Enantioselectivity." Doctoral thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122424.

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The work leading to this thesis has provided additional information and novel knowledge concerning structure-function relationship in the potato epoxide hydrolase. Epoxide hydrolases are enzymes catalyzing the hydrolysis of epoxides to yield the corresponding vicinal diols. The reaction mechanism proceeds via a nucleophilic attack resulting in a covalent alkylenzyme intermediate, which in turn is attacked by a base-activated water molecule, followed by product release. Epoxides and diols are precursors in the production of chiral compounds and the use of epoxide hydrolases as biocatalysts is growing. The promising biocatalyst StEH1, a plant epoxide hydrolase from potato, has been investigated in this thesis. In paper I the active site residue Glu35, was established to be important for the formation of the alkylenzyme intermediate, activating the nucleophile for attack by facilitated proton release through a hydrogen bond network. Glu35 is also important during the hydrolytic half reaction by optimally orienting the hydrolytic water molecule, aiding in the important dual function of the histidine base. Glu35 makes it possible for the histidine to work as both an acid and a base. In paper II a putative proton wire composed of five water molecules lining a protein tunnel was proposed to facilitate effective proton transfer from the exterior to the active site, aiding in protonation of the alkylenzyme intermediate. The protein tunnel is also proposed to stabilize plant epoxide hydrolases via hydrogen bonds between water molecules and protein. Enzyme variants with modified enantiospecificity for the substrate (2,3-epoxypropyl)benzene have been constructed by in vitro evolution using the CASTing approach. Residues lining the active site pocket were targeted for mutagenesis. From the second generation libraries a quadruple enzyme variant, W106L/L109Y/V141K/I155V, displayed a radical shift in enantioselectivity. The wild-type enzyme favored the S-enantiomer with a ratio of 2:1, whereas the quadruple variant showed a 15:1 preference for the R-enantiomer.
4

Ching-Tzu, Lu, and 盧靜姿. "The Entry and Exit Model of Taiwan Enterprise’s Leasing Market in China under the Different Risk Function." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/15102816854963921667.

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碩士
銘傳大學
管理科學研究所
90
This paper is to utilize the real options approach for evaluating Taiwan’s commercial banks making single entry and extended entry and exit models into the Taiwan enterprise’s leasing market in China. According to the leasing market endures different degrees of risk, we try to apply different utility functions in each models. Under uncertainty of revenue in the leasing market, the best solution, the threshold value for entry and exit strategy, the potential project value and sensitive analysis will be calculated. We also compare some different results by traditional net present value method and real options approach, to provide decision maker for another way of thinking. This thesis utilizes the real options approach for evaluating commercial banks to derive two results as follows:1. The entry threshold value of ROA is higher than NPV’s. The exit threshold value of ROA is lower than NPV’s. The reason is that the potential value of waiting investment doesn’t involve by NPV method. It also means that the decision of ROA is more conservative than NPV under uncertainty. 2. Investors tend to conservative the higher thresholds they want no matter utilize the single entry or extended entry and exit models of ROA or NPV method.

Книги з теми "Entry–exit function":

1

Honig, Dan. Agents. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190672454.003.0003.

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This chapter discusses agent judgment and when relying on agents will be a more or less reliable strategy. The chapter explores agent motivation and why it is critical to successful Navigation by Judgment. Agent motivation is a function of both treatment and selection effects. Job design can play an important role in changing agent motivation for better or for worse (treatment); job design can also prompt differential exit and entry of motivated agents into international development organizations (IDOs) (selection). It argues that there may be different equilibria IDOs can meet, with a Theory Y equilibrium of agent initiative and intrinsically motivated agents on the one hand and a Theory X equilibrium of tight principal control and extrinsically motivated agents on the other.

Частини книг з теми "Entry–exit function":

1

Güneş, Nizamülmülk. "Market Structure of the Banking Sector and the Turkish Banking Sector." In Handbook of Research on Institutional, Economic, and Social Impacts of Globalization and Liberalization, 584–604. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-4459-4.ch032.

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The main function of banking is to contribute to economic growth by providing sectors outside of the finance section with financing that they need and fulfilling an intermediary role between lenders and borrowers. This intermediary function increases the importance of the banking sector compared to other sectors of the economy. Market structures are very significant in terms of firms' market entry and exit and stay on the market. Markets are subject to four different distinction as perfect competition, monopoly, oligopoly, and monopolistic competition markets. The objective in the market is to ensure efficiency in production and sales by pulling down the costs of production through competition. The factors determining the market structure are the numbers of firms in the sector, the degree of restriction on the entry and exit of firms in the industry, the number of those requesting products and homogeneity degree of product produced The banking sector, unlike other sectors, has unique characteristics. Competition policies which are valid in other sectors are not appropriate for the banking industry. Market openness for instability and market failures change the structure of competition. Asymmetric information, product replacement costs and externalities create barriers to entry which, allows banks to be in a dominant position in their markets. This study examines the main indicators showing concentration, effectiveness, depth, and intermediation functions of Turkish banking sector and investigates in which market structure the sector operates. In this regard, it has made policy recommendations over the results obtained.
2

Thorburn, Malcolm. "Roles and Offices at the Border." In Privatising Border Control, 77—C4.P69. Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/oso/9780192857163.003.0005.

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Abstract This chapter argues that border control is an intrinsically public function and should not be carried out by private actors. In doing so, it also develops a robust account of public office more generally. The chapter’s argument challenges both the moral individualism of Jeff McMahan, John Gardner, or Ashwini Vasanthakumar, and the influential anti-privatisation argument of Alon Harel and Avihay Dorfman. Against the moral individualists, it is shown that the legitimacy of border security requires that it be carried out in the name of the whole people of the host country and only public officials can do that. Against Dorfman and Harel, it is argued that their conception of public office is too thin. Although they insist that only public officials can speak in the name of the public (because of their place within a ‘community of practice’ through ‘fidelity by deference’), they neglect other crucial features of public office, such as constraints on entry and exit, limits on conflicts of interest, training, and more.
3

Barnett, Jonathan M. "Dynamic Analysis of Intellectual Property." In Innovators, Firms, and Markets, 9–22. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190908591.003.0002.

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This chapter proposes a dynamic approach to IP analysis that assesses the effects of changes in the strength of IP rights by anticipating firms’ ability to adopt alternative non-IP mechanisms for capturing returns on innovation. Some of the most powerful non-IP alternatives are the economies of scale, financing capacities, and accumulated goodwill that are inherent to older, larger, and more integrated entities. By contrast, these non-IP alternatives are generally unavailable to younger, smaller, and less integrated entities. These entity-specific differences in adopting non-IP alternatives imply that changes in the strength of IP rights can have significantly different effects on different entity types as a function of age, size, and level of integration. Critically, weak- or zero-IP regimes can advantage large incumbents by compelling exit or deterring entry by smaller and less integrated firms that cannot sufficiently monetize R&D investments in the absence of reasonably secure IP protections.
4

"Appendix Four. Functions of Public Security Departments in Relation to Exit and Entry Administration." In The Right to Leave and Return and Chinese Migration Law, 332–39. Brill | Nijhoff, 2007. http://dx.doi.org/10.1163/ej.9789004156142.i-428.94.

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5

"Appendix Five. Functions of Foreign Affairs Departments in Relation to Exit and Entry Administration." In The Right to Leave and Return and Chinese Migration Law, 340–42. Brill | Nijhoff, 2007. http://dx.doi.org/10.1163/ej.9789004156142.i-428.95.

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"Appendix Ten. Functions of Other Departments and Units in Relation to Exit and Entry Administration." In The Right to Leave and Return and Chinese Migration Law, 352–54. Brill | Nijhoff, 2007. http://dx.doi.org/10.1163/ej.9789004156142.i-428.100.

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"Appendix Nine. Functions of Other Responsible Governmental Departments in Relation to Exit and Entry Administration." In The Right to Leave and Return and Chinese Migration Law, 350–51. Brill | Nijhoff, 2007. http://dx.doi.org/10.1163/ej.9789004156142.i-428.99.

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8

Herbinger, Paul, Marion Neinkirchner, and Norbert Leonhardmair. "Frontline Response to High Impact Domestic Violence in Austria." In Improving Frontline Responses to Domestic Violence in Europe. University of Maribor, University Press, 2021. http://dx.doi.org/10.18690/978-961-286-543-6.7.

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The networked response to cases of high-impact domestic violence in Austria predominantly involves four groups of actors, who share both formal and informal modes of interagency cooperation, and each function as independent entry points to a networked intervention. These groups consist of specialised and non-specialised police officers, a number of NGOs in the social sector, regional administration and municipal authorities, as well as the medical sector, predominantly involving hospital staff. The most important legal measure in place for the protection of victims by police is the restraining order in the Security Police Act, which was introduced as part of the victim protection guidelines. A unified and universally applied definition of domestic violence does not exist in Austria. As a result, there is no cross-sectoral standardisation when identifying violent acts. Nevertheless, the networked response in Austria is characterized by a robust system of inter-agency referrals and formalized cooperation.
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"Appendix Seven. Functions of Hong Kong and Macao Affairs Offices, Taiwan Affairs Offices and Overseas Chinese Affairs Offices in Relation to Exit and Entry Administration." In The Right to Leave and Return and Chinese Migration Law, 345–46. Brill | Nijhoff, 2007. http://dx.doi.org/10.1163/ej.9789004156142.i-428.97.

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10

Malveaux, Gregory F. "How to Survive and Thrive as a Community College Consortium." In Study Abroad Opportunities for Community College Students and Strategies for Global Learning, 265–83. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-6252-8.ch019.

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Some state and regional study abroad and international education-based consortia of community colleges have been struggling to remain operational. Key outside factors that have created trials include the United States' (US) economic downturn that ensued from 2007-2009, ongoing regulations set by government officials, and internal logistical challenges such as changes in leadership at member institutions, alterations in financial aid requirements, and emphasis placed on degree completion. There has been much analysis on “why” these consortia exist in the field; in contrast, this chapter focuses on “how” they persist. The Maryland Community College International Education Consortium (MCCIEC) is one of the nation's state consortia that continue to be active and flourish, navigating through economic trials, governmental policies that offset international student entry in to American higher education, and common logistical issues; this chapter uses MCCIEC as an illustrative model to show how community college consortia may function to prosper. MCCIEC uses four main approaches—1) gaining higher administrative buy-in, 2) encouraging full institutional support at membership colleges, 3) incorporating strong incentives for member activity, and 4) stimulating growth—to not only survive, but to thrive.

Тези доповідей конференцій з теми "Entry–exit function":

1

Chow, S. K., and J. J. McGuirk. "Numerical Prediction of Flow and Combustion Characteristics of a Model Annular Combustor." In ASME 1991 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1991. http://dx.doi.org/10.1115/91-gt-364.

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Two instantaneous chemistry descriptions (full chemical equilibrium and laminar flamelet) were applid to the prediction of gaseous reaction in a small-scale combustor. The chemical state relationships were combined with a single conserved scalar/β-function pdf/k-ε turbulence model closure. Encouraging results were obtained for the flowfield and conserved scalar distributions, although only when the jet entry boundary conditions were altered to accord closely with several expected experimental features. These predictions imply that any acceptable approach to combustor modelling must extend calculations to include the outer annulus. Exit temperature levels were predicted fairly well, but the quality of internal distributions deteriorated due to errors in predicted fuel/air mixing. Differences between the two chemistry models were small except for CO and H2 species concentrations where the flamelet model gave better agreement with experiments.
2

Horlock, J. H., D. T. Watson, and T. V. Jones. "Limitations on Gas Turbine Performance Imposed by Large Turbine Cooling Flows." In ASME Turbo Expo 2000: Power for Land, Sea, and Air. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/2000-gt-0635.

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Calculations of the performance of modern gas turbines usually include allowance for cooling air flow rate; assumptions are made for the amount of the cooling air bled from the compressor, as a fraction of the mainstream flow, but this fractional figure is often set in relatively arbitrary fashion. There are two essential effects of turbine blade cooling: [i] the reduction of the gas stagnation temperature at exit from the combustion chamber [entry to the first nozzle row] to a lower stagnation temperature at entry to the first rotor and [ii] a pressure loss resulting from mixing the cooling air with the mainstream. Similar effects occur in the following cooled blade rows. The paper reviews established methods for determining the amount of cooling air required and semi-empirical relations, for film cooled blading with thermal barrier coatings, are derived. Similarly, the pressure losses related to elements of cooling air leaving at various points round the blade surface are integrated over the whole blade. This gives another semi-empirical expression, this time for the complete mixing pressure loss in the blade row, as a function of the total cooling air used. These two relationships are then used in comprehensive calculations of the performance of a simple open-cycle gas turbine, for varying combustion temperature and pressure ratio. These calculations suggest that for maximum plant efficiency there may be a limiting combustion temperature [below that which would be set by stoichiometric combustion]. For a given combustion temperature, the optimum pressure ratio is reduced by the effect of cooling air.
3

Knobloch, Aaron J., Joell R. Hibshman, George Wu, and Rich Saia. "Experimental Study of Entrance Effects on Laminar Gas Flow Through Silicon Orifices." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-80230.

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This study summarizes a fundamental investigation of flow through an array of silicon micromachined rectangular slots. The purpose of the study is to evaluate the effect of entrance pressure, flow area, orifice thickness, slot length, and slot width of the orifice on flow rate. These orifices were fabricated using a simple frontside through wafer DRIE process on a 385 μm thick wafer and wafer bonding to create thicker orifices. The dies were then packaged as part of a TO8 can and flow tested. To complement the results of this experimental work, two simple flow models were developed to predict the effect of geometrical and entrance conditions on the flow rate. These models were based on macroscale assumptions that were not necessarily true in the case of thin orifices. One relationship was based on Pouiselle flow which assumes fully developed flow conditions. Calculation of the entry length required for fully developed flow indicate that in the low Reynolds Number regime (32-550) evaluated, the entry flow development requires 2-8 times the thickness of the thickest orifices used for this study. Therefore, calculations of orifice flow based on a Pouiselle model are an overestimate of the actual measured flow rates. Another model examined typical orifice relationships using head loss at the entrance and exit of the slots did not accurately capture the particular flow rates since it overestimated the expansion or constriction losses. A series of experiments where the pressure was varied between 75 and 1000 Pa were performed. A comparison of the Pouiselle flow solution with experimental results was made which showed that the Pouiselle flow model overpredicts the flow rates and more specifically, the effect of width on the flow rates. The results of these tests were used to develop a transfer function which describes the dependence of flow rate on orifice width, thickness, length, and inlet pressure.
4

Akopov, Garnik V. "CONTEMPLATION: THE RATIO OF CONSCIOUS AND UNCONSCIOUS." In International Psychological Applications Conference and Trends. inScience Press, 2021. http://dx.doi.org/10.36315/2021inpact010.

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"In psychological science, the concept of contemplation is not included in the most important categories of psychology, such as activity, consciousness, personality. The dictionary meanings of the term “contemplation” are ambiguous. In psychology, in addition to the categorical analysis of contemplation (S.L. Rubinstein) and its attribution to fundamental concepts (A.V. Brushlinsky), there are also interpretations of contemplation, which are synonymous to intuition (A. Bergson) and meditation (V.F. Petrenko, Han F. De Wit), insight (preconceptual thinking - T.K. Rulina), mystical states (W. James, P.S. Gurevich). Contemplation, unlike intuition, meditation and insight, does not have a previous reportable history. In our studies, contemplation is considered as an unconscious mental phenomenon that exists in the forms of a process, state, and also the properties of an individual (contemplative personality). Not coinciding with the processes of attention, memory, perception, thinking, etc., contemplation, however, is activated on their basis. The difference lies in the uncontrollability of this process, since its contents are not presented to consciousness. Therefore, contemplation is also different from dreams, experiences, intentions and other internally substantive mental phenomena. Despite the fact that consciousness does not have access to the content of contemplation (access-consciousness), the process itself is realized by man. In this we see the difference between contemplation as unconscious activity and Freudian understanding of the unconscious. Other differences are: involuntary entry and random exit from the state of contemplation; emotional equipotentiality of contemplation, i.e. the invariability of the emotional background of contemplation from the beginning to the exit from it. In ontogenesis, contemplation is most clearly represented in infancy, in youth, and in old age, as well as during periods of age and other life crises. Reminiscences of students record the age range from 11 to 17 years as the most saturated with contemplation; least at the age of 6-8 years (L.S. Akopian). Contemplation as an unconscious activity periodically replaces purposeful activity, contributing to the maturation, correction, transformation of the person’s life meanings in their micro-, meso- and macro-macro dimensions. Contemplation also fulfills the function of partially liberating oneself from an excess of affairs, concerns, plans, aspirations, and other forms of conscious activity. The development of practice-oriented forms of actualization of contemplation will expand the range of psychotherapeutic methods."
5

Al-Asmi, I., A. Vandel, G. Cabot, F. Grisch, V. Moureau, N. Savary, S. Richard, and B. Renou. "Integration of Helicopter Annular Combustion Chamber Rig in Propulsion Systems Course for Graduate Students." In ASME Turbo Expo 2018: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/gt2018-75610.

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The integration of graduate research in the training of engineering students has demonstrated a significant increase in learning efficiency, by giving them a practical experience with real industrial issues. The department of Energy and Propulsion of National Institute of Applied Sciences in Normandy, a French Engineering School, continues to implement the latest fully instrumented facilities in their field to initiate the students to inquiry-based education courses. In this type of education, they are carrying out a series of tests, learning how to handle equipment, control and monitor tests, extract results and ultimately analyze and present them in technical reports. This paper addresses how the Helicopter Annular Combustion Chamber test facility has been integrated in the Propulsion systems engineering course sequence. The Annular Combustion Chamber kindly provided by SAFRAN Helicopter Engines was progressively incorporated and instrumented in a dedicated test facility by the students themselves along the last 8 years. Now, this laboratory practical work offers the students the possibility to interactively learn about the operation of a combustion chamber inside a helicopter engine at various air/fuel flow rates. Students learn how to determine the limits of ignition/non-extinction as a function of the entry air-flow rate. In addition, this facility is equipped with high-level instrumentation that allows to measure the different flow rates, pressure, temperature inside and outside the annular chamber, and the pollutant emissions at the exit. Results provided by students help to build a comprehensive knowledge base of combustion phenomena inside a turbojet engine. It is to be mentioned that this educational facility is unique in its category, from the point of view of results accuracy, instrumentation level and realistic operating conditions.
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Rojas, Guillermo, Oscar E. Bautista, and Federico Mendez. "Effect of Hydrodynamic Slippage on Oscillating Electroosmotic Flows in Infinitely Extended Microcapillary." In ASME 2015 13th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2015 International Technical Conference and Exhibition on Packaging and Integration of Electronic and Photonic Microsystems. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/icnmm2015-48776.

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In this work we conduct a numerical analysis of the time periodic electroosmotic flow in a cylindrical microcapillary, whose wall is considered hydrophobic. The fluid motion is driven by the sudden imposition of a time-dependent electric field. The electrical potential is obtained by solving the nonlinear Poisson-Boltzmann equation for high zeta potential, under the assumption that the electrokinetic potential is not affected by the oscillatory external field. In addition, we neglect the channel entry and exit effects, in such manner that the flow is fully developed. The governing equations are nondimensionalized, and the solution is obtained as a function of three dimensionless parameters: the ratio of the Navier slip length to the radius of the microcapillary, δ; Rω, which is the dimensionless frequency for the flow or Strouhal number and measures the competition between the diffusion time to the time scale associated to the frequency of the oscillatory electric field; and κ, which represents the ratio of the radius of the microcapillary to the Debye length. The principal results show that using slippage, the bulk velocity increases for increasing values of δ. For the values of the dimensionless parameters used in this analysis, by using hydrophobic walls, the bulk velocity can be increased in about 20% in comparison with the case of no-slip boundary condition. On the other hand, the dimensionless frequency for the flow or Strouhal number plays a fundamental role in determining the motion of the fluid. For Rω ≪ 1, the dissipation is found in resonance with the frequency of the oscillatory electric field. For Rω ≫ 1, the dissipation is not in phase with the frequency and, therefore, the velocity in the center of the microcapillary, in some cases, is almost null, and the maximum value of the velocity is near to the microcapillary wall.
7

Ferry, W., and D. Yip-Hoi. "Cutter-Workpiece Engagement Calculations by Parallel Slicing for Five-Axis Flank Milling of Jet Engine Impellers." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-41434.

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Cutter-workpiece engagement maps, or cutting flute entry/exit locations as a function of height, are a requirement for prediction of cutting-forces on the tool and workpiece in machining operations such as milling. This paper presents a new method of calculating tool-part intersection maps for five-axis flank milling of jet engine impellers with tapered ball-end mills. It is called the parallel slicing method (PSM) and is a semi-discrete solid modeling technique written in C++ using the ACIS B-rep solid modeling environment. Although it is tailored towards five-axis flank milling, it can also be applied to both planar and multi-axis milling processes. The tool swept envelope is generated and intersected with the workpiece to obtain the removal volume. The removal volume is then sliced into a number of parallel planes along a given axis and the intersection curves with the tool and each plane are determined analytically. The swept area between the intersection curves of successive tool moves is calculated by solving for the area enclosed by the tangent lines. This area is removed from the workpiece material, which deletes the material cut between tool moves. Finally, the intersection curves are compared with the planar slices of the updated part, which results in a series of arcs. The end points of these arcs are joined with linear segments to form the engagement polygon which is used to calculate the engagement maps. Using this method, cutter-workpiece engagement maps are generated for a five-axis flank milling toolpath on a prototype integrally bladed rotor (IBR) with a tapered ball-end mill. These maps are compared with those obtained from a benchmark cutter-workpiece engagement calculation method – the Manufacturing Automation Laboratory’s Virtual Machining Interface (MAL-VMI). The MAL-VMI uses an application programming interface (API) in a commercial NC verification software package to obtain cutter-part intersections through a fast, z-buffer technique. Overall, the parallel slicing method appears to obtain more accurate engagement zones than those given by the MAL-VMI, although the calculation time is longer.
8

Wells, Arthur, Kyle McGann, and John Parmigiani. "Semi-Truck Driver Safe Egress Analysis and Renovation." In ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-24019.

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Abstract The backbone of most supply chains is the trucking business. This highly competitive industry requires that loads be delivered on-time and in an economic manner. A major logistics company has found that accidents causing driver injury are inhibiting their ability to meet both requirements. Non-fatal injuries for truck drivers are 7 times the national average, and 30% of these are from falls, slips, and trips. Specifically, an ongoing problem is drivers slipping and falling when entering and exiting tractor cabs. Better entry-and-exit hardware and procedures need to be developed and implemented. To contribute to solving this problem, Oregon State University (OSU) was contacted by a major truck manufacturer to develop supplemental hardware and procedures. The project was pursued through OSU’s Prototype Development Lab (PDL). The work performed consisted of (i) a background investigation to determine accident root causes, (ii) development of alternative design solutions, (iii) selection of a preferred design solution through consultation with all stakeholders, (iv) development of the preferred solution consisting of a hardware prototype and associated procedures, and (v) evaluation and revision of the solution based on user feedback. The background investigation was performed as follows. To determine the causes, the company’s safety procedures and incident reports were reviewed. From this information, a driver survey was developed. This provided a data set from which an industrial engineering analysis was performed. The root causes of the accidents were clearly identified. These are: slipping on steps, not following the “three points of contact” rule, and the handles not proving appropriate grip. Slipping and not having enough grip is a design problem with the driver hardware aids for transiting to and from the cab. Not following procedure is a behavioral problem. There is a well-engineered procedure in place for transiting between the cab and the ground. However, drivers often circumvent this solution leading to accidents. Alternative design solutions were created to address both the shortcomings of the current hardware and the current circumventable procedures. This consisted of four mechanical-device concepts that could be retrofitted to existing cabs that improved grip and prevented the drivers from exiting the cab in a manner contrary to the established procedures. The design selection was performed based on feedback from project stakeholders. Ultimately, the effectiveness of the solutions was determined by driver response, so a second survey was made to gauge driver feedback. This was used to present the options to the trucking manufacturer and logistics company. A single design solution was chosen. The solution was an additional mechanical handle retrofitted to the cab. This handle swings out from the driver’s foot-well and impedes entering and exiting the cab in an improper manner. It also provides a more accessible, more rigid point of contact. To evaluate this solution, a prototype polyethylene handle was made to determine proper placement and function in a truck cab. From this, the handle was revised, and a functional prototype was created. This allowed testing and an ergonomic study to be performed. A final design was then created. This was forwarded to the truck manufacturer for final development and mass production.
9

Baarholm, Rolf. "A Simple Numerical Method for Evaluation of Water Impact Loads on Decks of Large-Volume Offshore Platforms." In ASME 2005 24th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2005. http://dx.doi.org/10.1115/omae2005-67097.

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A simple method for solving water impact loads underneath decks of offshore structures is developed. In the present paper the emphasis is on the vertical loads, but in principle the suggested method can also be applied to horizontal loading. The suggested method is three-dimensional and valid for general deck geometries and arbitrary incoming wave direction. First and second order wave amplification due to the large-volume structure is included in the analysis. An important feature of the present approach is that added mass of the instantaneous wetted deck area is approximated by the added mass of thin rectangular or elliptical plates. A numerical tool for solving the impact loads is implemented. This tool uses the results from an a priori second order diffraction analysis of the platform hull. In particular the wave-in-deck simulation program applies linear and quadratic transfer functions from the diffraction analysis as input. Since pre-computed hydrodynamic quantities are used in the simulations, very fast computations can be performed. The method is validated against experiments. Results from scaled model tests of the Statfjord A gravity-based structure (GBS) have been compared to numerical results. The comparisons are limited to regular waves. Satisfactory results are obtained from the numerical simulations. The theoretical results compare well with the experiments for the most severe cases. The vertical loads on the deck are well reproduced both during the water entry phase and the water exit phase. Moreover, the duration of the wave-in-deck event is satisfactorily predicted.
10

Ashcroft, Graham, Christian Frey, Hans-Peter Kersken, Edmund Kügeler, and Nina Wolfrum. "On the Simulation of Unsteady Turbulence and Transition Effects in a Multistage Low Pressure Turbine: Part I — Verification and Validation." In ASME Turbo Expo 2018: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/gt2018-76756.

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This is the first part of a series of three papers on the simulation of turbulence and transition effects in a multistage low pressure turbine. In this first part, the extension, verification and validation of a Harmonic Balance (HB) method recently proposed by the authors to fully include established turbulence and transition models in the method is presented. As an alternating frequency/time-domain type method the implemented HB solver has the advantage of being able to utilize models (e.g. boundary conditions or residual functions) formulated in either the frequency- or time-domain. On the one hand this allows highly accurate nonreflecting boundary conditions formulated in the frequency-domain to be used along entry, exit or interface boundaries, and on the other hand complex nonlinear terms formulated in the time-domain to be used to describe nonlinear effects. Nevertheless, the wish to minimize the number of harmonics used to describe a given time-periodic unsteady flow, coupled with the often highly nonlinear nature of turbulence and transition models makes the full inclusion of such models in the HB method challenging. In this work the integration of Menter’s SST two-equation k–ω turbulence model along with Menter and Langtry’s two-equation γ–Reθ transition model in the context of a general framework for transport equations in the CFD solver TRACE is described in detail. Following the basic verification of the underlying transport equation framework, the implemented models are used to compute the well known high lift, low pressure turbine airfoil T106C and results are compared with the available experimental data as well as results from more conventional time-domain simulations. Alongside the basic validation of the models this testcase is furthermore used to investigate the importance of including higher harmonics, as opposed to only the zeroth harmonic, of the turbulence and transition models for the accurate prediction of the time-mean flow.

Звіти організацій з теми "Entry–exit function":

1

Citovsky, Vitaly, and Yedidya Gafni. Viral and Host Cell Determinants of Nuclear Import and Export of the Tomato Yellow Leaf Curl Virus in Tomato Plants. United States Department of Agriculture, August 2002. http://dx.doi.org/10.32747/2002.7585200.bard.

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Tomato yellow leaf curl geminivirus (TYLCV) is a major pathogen of cultivated tomato, causing up to 100% crop loss in many parts of the world. In Israel, where TYLCV epidemics have been recorded since the 1960' s, this viral disease is well known and has been of economic significance ever since. In recent years, TYLCV outbreaks also occurred in the "New World" - Cuba, The Dominican Republic, and in the USA, in Florida, Georgia and Louisiana. Thus, TYLCV substantially hinders tomato growth throughout the world. Surprisingly, however, little is known about the molecular mechanisms of TYLCV interaction with the host tomato cells. The present proposal, a continuation of the project supported by BARD from 1994, expanded our understanding of the molecular mechanisms by which TYLCV enters the host cell nucleus for replication and transcription and exits it for the subsequent cell-to-cell spread. Our project sought two objectives: I. To study the roles of the viral capsid protein (CP) and host cell factors in TYLCV nuclear import. II. To study the roles of CP and host cell factors in TYLCV nuclear export. Our research toward these goals have produced the following major achievements: . Developed a one-hybrid assay for protein nuclear export and import (#3 in the List of Publications). . Identified a functional nuclear export signal (NES) in the capsid protein (CP) of TYLCV (#3 in the List of Publications). . Discovered homotypic interactions between intact TYLCV CP molecules and analyzed these interactions using deletion mutagenesis of TYLCV CP (#5 in the List of Publications). . Showed developmental and tissue-specific expression of the host factor required for nuclear import of TYLCV CP, tomato karyopherin alpha 1, in transgenic tomato plants (#14 in the List of Publications). . By analogy to nuclear import of TYLCV ,identified an Arabidopsis VIPI protein that participates in nuclear import of Agrobacterium T -complexes via the karyopherin alpha pathway (#4,6, and 8 in the List of Publications). These research findings provided significant insights into (i) the molecular pathway of TYLCV entry into the host cell nucleus, and (ii) the mechanism by which TYLCV is exported from the nucleus for the cell-to-cell spread of infection. Furthermore, the obtained knowledge will help to develop specific strategies to attenuate TYLCV infection, for example, by blocking viral entry into and/or exit out of the host cell nucleus. Also, as much of our findings is relevant to all geminiviruses, new anti- TYLCV approaches developed based on the results of our research will be useful to combat other members of the Geminivirus family. Finally, in addition to the study of TYLCV nuclear import and export, our research contributed to our understanding of general mechanisms for nucleocytoplasmic shuttling of proteins and nucleic acids in plant cells.

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