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Статті в журналах з теми "Heart Diseases Prevention":

1

Kulmane, Edite, Mara Pilmane, and Romans Lacis. "Apoptosis, ANUP, Chromogranin A, PGP 9.5, Endothelins and VEGF in Acquired Heart Diseases: Review of Literature." Acta Chirurgica Latviensis 15, no. 1 (April 2015): 63–72. http://dx.doi.org/10.1515/chilat-2016-0012.

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Summary According to the Centre for Disease Prevention and Control of Latvia data, in 2014 16076 latvians died from cardiovascular diseases and it is 57,03% of all deaths. Changes in myocardium of the diseased hearts are complex and pathogenesis is still not fully clear. Morphopathogenesis of cardiovascular diseases are complex molecular cell changes which include apoptosis, homeostasis regulating factors, and innervation and ischemia markers. In this article we wanted to provide an overview about apoptosis, atrial natriuretic peptide, chromogranin A, neuropeptide-containing innervation, endothelins and vascular endothelial growth factor in pathomorphology of acquired heart diseases and their clinical implications.
2

Asthana, Alok Kumar, Monika Asthana, and Payal Sharma. "PREVENTION OF CARDIO VASCULAR DISEASE THROUGH AYURVEDA." Asian Journal of Pharmaceutical Research and Development 6, no. 4 (August 2018): 97–100. http://dx.doi.org/10.22270/ajprd.v6i4.379.

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In today's era non communicable diseases are most prevalent diseases. They are also known as chronic diseases. Cardiovascular disease (heart disease) or Hridaroga is one of them. This is a lifestyle disorder and that’s why we should always focus on a healthy lifestyle. A healthy lifestyle can reduce the risk of this lethal disease. Our various bad food habits and sedentary lifestyle are the major causes for heart disease. This article will provide all of us a brief knowledge of heart disease (hridaroga). One has correctly said “Prevention is better than cure”. So, this article will mainly focus on how we can prevent heart disease through ayurveda. Ayurveda is the best pathy to prevent lifestyle disorder. Here we will see various yoga asanas, various dietary habits, lifestyle modifications we can do to prevent the disease. Keywords: Hridaroga, hridashoola, CVD
3

Haque, KMHS Sirajul. "Prevention of Rheumatic Fever and Rheumatic Heart Diseases in Bangladesh." Cardiovascular Journal 11, no. 2 (February 2019): 91–92. http://dx.doi.org/10.3329/cardio.v11i2.40407.

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4

Matuz-Mares, Deyamira, Héctor Riveros-Rosas, María Magdalena Vilchis-Landeros, and Héctor Vázquez-Meza. "Glutathione Participation in the Prevention of Cardiovascular Diseases." Antioxidants 10, no. 8 (July 2021): 1220. http://dx.doi.org/10.3390/antiox10081220.

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Cardiovascular diseases (CVD) (such as occlusion of the coronary arteries, hypertensive heart diseases and strokes) are diseases that generate thousands of patients with a high mortality rate worldwide. Many of these cardiovascular pathologies, during their development, generate a state of oxidative stress that leads to a deterioration in the patient’s conditions associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Within these reactive species we find superoxide anion (O2•–), hydroxyl radical (•OH), nitric oxide (NO•), as well as other species of non-free radicals such as hydrogen peroxide (H2O2), hypochlorous acid (HClO) and peroxynitrite (ONOO–). A molecule that actively participates in counteracting the oxidizing effect of reactive species is reduced glutathione (GSH), a tripeptide that is present in all tissues and that its synthesis and/or regeneration is very important to be able to respond to the increase in oxidizing agents. In this review, we will address the role of glutathione, its synthesis in both the heart and the liver, and its importance in preventing or reducing deleterious ROS effects in cardiovascular diseases.
5

Sirota, N. A., O. V. Sivakova, and V. M. Yaltonsky. "Dynamics of Risk Factors of Heart Diseases Under Influence of Remote Medical-Psychological Consulting." Консультативная психология и психотерапия 27, no. 3 (2019): 175–96. http://dx.doi.org/10.17759/cpp.2019270311.

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The problem of preventive treatment of people displaying risk factors for cardiovascular diseases (RF CVD) is extremely important. At the same time, despite the proven high efficacy of prevention of CVD, the compliance is still low. In this regard, it is important to develop new approaches to control and improve the profile of RF CVD. The article presents the results of the application of innovative methods of medical and psychological counseling. This methodology combines the most important achievements of three major developing areas of work with the patient: 1) medical psychology (using the methods of motivational counseling, coping prevention, etc.); 2) therapy and cardiology; 3) the use of modern remote digital technologies. The results of the study show the effectiveness of the method of remote medical and psychological counseling to monitor and improve the profile of RF CVD.
6

Lüscher, Thomas F. "Prevention of non-communicable diseases and special causes of heart failure." European Heart Journal 36, no. 31 (August 2015): 2019–22. http://dx.doi.org/10.1093/eurheartj/ehv303.

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7

Passarella, G., G. Trifirò, M. Gasparetto, G. Svaluto Moreolo, and O. Milanesi. "Disorders in Glucidic Metabolism and Congenital Heart Diseases: Detection and Prevention." Pediatric Cardiology 34, no. 4 (November 2012): 931–37. http://dx.doi.org/10.1007/s00246-012-0577-0.

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8

Larina, V. N., D. S. Mkrtychev, V. A. Kuznetsova, and A. A. Tyazhelnikov. "Possible Approaches to Primary Prevention of Cardiovascular Diseases." Rational Pharmacotherapy in Cardiology 16, no. 5 (November 2020): 831–41. http://dx.doi.org/10.20996/1819-6446-2020-10-12.

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In recent years there is a positive trend in the development of preventive medicine, in particular, primary prevention of diseases. However, in most cases, patients seek help from a doctor after the manifestation of the disease, and therefore, early identification of risk factors (RF) remains relevant. Conduction of a large number of studies that are aimed at studying modifiable RF associated with the development of cardiovascular diseases (CVD), allowed the experts of the American Heart Association to develop recommendations “Life's Simple 7”, which makes it possible to structure methods of primary prevention of CVD and minimize the risk of their development. In 2019, experts from the American College of Cardiology presented a simplified version of these recommendations, to improve approaches to primary prevention and their effectiveness not only for doctors but also for patients. Thus, by involving the patient in the decision-making process about follow-up treatment, doctors can achieve a high level of compliance, which is essential for improving the prognosis. The “ABCDE” recommendations, in name of which are reflected the first letters of the leading CVD RF, include such paragraphs as RF assessment, the use of antiaggregating therapy, correction of blood pressure, cholesterol levels, smoking elimination, correction of high glucose levels and diabetes treatment, weight loss, assessment of social and economic factors affecting the morbidity in a particular patient. Despite the undoubted benefit of the “ABCDE” recommendations, some problems of primary prevention currently cannot be solved: the inability to accurately assess social and economic RF; the imperfection of the used CVD risk scales. The updated version of the recommendations allows not only to assess the existing RF of the patient, but also to effectively correct them. In addition, the patient himself can read the recommendations, which improves understanding of the primary prevention importance.
9

Stewart, Bernard W., and Alan S. Coates. "Cancer Prevention: A Global Perspective." Journal of Clinical Oncology 23, no. 2 (January 2005): 392–403. http://dx.doi.org/10.1200/jco.2005.05.132.

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This review will be restricted to measures aimed at primary prevention of cancer; reduction of the death rate through screening will not be covered. In many instances, cancer prevention is just one outcome of the benefits of good health practices, which may also benefit cardiovascular, lung, infectious, and metabolic diseases. Thus, reducing tobacco smoking will bring benefits in heart disease, neonatal and maternal health, stroke, and peripheral vascular disease as well as a variety of cancers, while dietary advice appropriate to cancer risk reduction will bring benefits in diabetes, stroke, kidney, and heart disease.
10

Dian Wahyuni. "Prevention & Control Efforts Non-Communicable Diseases (PTM); Hypertension." Conferences of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sriwijaya 2, no. 1 (November 2020): 145–52. http://dx.doi.org/10.32539/dies.v2i1.52.

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BALITBANG KEMENKES in 2020 release data in the form of tendency of non-communicable diseases (PTM) starting from the age of 10-14 years including increasing heart pressure. The purpose of this avenue is describing the prevention and control of hypertension. The method used by the online education seminar on health cadres in Sakatiga village, FK UNSRI fostered village since 2014. Finally, it is hoped that the community (cadres) can understand and implement efforts to prevent and control hypertension in the form of routinely measuring blood pressure, taking hypertension medication regularly and using complementary therapies.

Дисертації з теми "Heart Diseases Prevention":

1

李雯靜 and Man-ching Anney Lee. "Effects of the disease management programme with nurse-led heart failure clinic." PG_Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40721036.

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2

Masoud, Mohamed Abdulsalam. "Validation of a recently proposed equation for the estimation of small, dense LDL particles from routine lipid measures in a population of mixed ancestry South Africans." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2490.

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Thesis (MSc (Biomedical Technology))--Cape Peninsula University of Technology, 2016.
Cardiovascular diseases (CVD) are the leading cause of global mortality, of which over 75% occurred in low- and middle-income countries such as South Africa. The lipid profile, specifically decreased levels of high density lipoprotein cholesterol (HDL-C), elevated triglyceride levels and the presence of small-dense low density lipoprotein (sdLDL) has been reported associated with CVD. An increased number of sdLDL is also common in metabolic syndrome (MetS), visceral obesity and diabetes mellitus, the last a known risk factor for CVD. The modification of low density lipoprotein (LDL) size, or number of sdLDL particles, has been reported to significantly reduce CVD risk, but not conclusively so and needs further investigation. In this regard, sdLDL particles are seldom estimated routinely for clinical use because of financial and other limitations. Currently, an alternative approach for estimating sdLDL is to use equations derived from routine lipid measures, as has been proposed by several groups. However, there is a need for extensive evaluation of this equation across different ethnic and disease groups, especially since reports showed an inadequate performance of the equation in a Korean population. The aim of this study was to assess the performance of a recently proposed equation for the estimation of sdLDL in healthy and diabetic mixed ancestry South Africans. Furthermore, we also investigated the role of sdLDL as a cardiometabolic risk factor, as measured against known risk factors such as the glycemic and lipid profiles.
3

Aachi, Venkat Raghav. "Preliminary Characterization of Mitochondrial ATP-sensitive Potassium Channel (MitoKATP) Activity in Mouse Heart Mitochondria." Text, PDXScholar, 2009. https://pdxscholar.library.pdx.edu/open_access_etds/1667.

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Myocardial ischemia, infarction, heart failure and arrhythmias are the manifestations of coronary artery disease. Reduction of ischemic damage is a major concern of cardiovascular biology research. As per recent studies, the mitochondrial ATP-sensitive potassium channel (mitoKATP) opening is believed to play key role in the physiology of cardioprotection, protection against ischemia-reperfusion injury or apoptosis. However, the structural information of mitoKATP is not precisely known. Elucidating the structural integrity and functioning of the mitoKATP is therefore a major goal of cardiovascular biology research. The known structure and function of the cell ATP-sensitive potassium channel (cellKATP) is functional in interpreting the structural and functional properties of mitoKATP. The primary goal of my research was to characterize the activity of mitoKATP in the isolated mitochondria from the control mouse heart. The mitoKATP activity, if preliminarily characterized in the control strains through the light scattering technique, then the structure of the channel could possibly be established and analyzed by means of the transgenic model and with the help of immunological techniques such as western blotting and immunoflorescence. With this experimental model it was possible to demonstrate that the mitoKATP activity in control mouse heart mitochondria is activated by potassium channel openers (KCOs) such as diazoxide and cromakalim and activators of mitoKATP such as PMA (phorbol12 myristate-13-acetate), and inhibited by KATP inhibitors such as glibenc1amide and 5-hydroxydecanoate (5 HD). It was evident that the KATP activity in mouse heart mitochondria was comparable to that exhibited by the rat heart mitochondria. The various selective and non-selective activators and inhibitors of the channel elicited their activity at a similar concentration used for the rat heart mitochondria. The results were reproducible in five independent experiments for each combination, further reinforcing the significance of existing channel activity in the mouse heart mitochondria.
4

Purdum, Michael B. "The Effects of Positive Emotion, Negative Emotion, Flourishing, and Languishing on Cardiovascular Risk." Thesis or Diss., University of North Texas, 2010. https://digital.library.unt.edu/ark:/67531/metadc30503/.

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Positive psychology has led a movement that concentrates on positive characteristics. The current study examined the relationship between positive emotions, negative emotions, flourishing, languishing, and cardiovascular functioning. The study uses guided imagery to help participants recall a negative emotional event and positive emotional event in a counterbalanced order. The reverse order allowed us to examine the differential contributions of stress buffering versus facilitated recovery effects to higher levels of heart rate variability (HRV). The study also examined the relationship between mental health categories and known cardiovascular disease risk. Univariate analysis of variance revealed that positive emotions can serve as a stress buffer and dampen cardiovascular responses to a negative event. Also, analysis revealed a trend for the prediction that positive emotions can facilitate cardiovascular recovery following a negative event. Exploratory analysis did not reveal differences between a facilitated recovery group and a buffering group for cardiovascular measures. Future studies should include tighter control to help compare the differential influences of stress facilitation and stress buffering on cardiovascular functioning. The results from the study indicate that it is still too early to tell whether mental health buffers those individuals from developing CVD, and to answer whether languishing increases the risk of CVD. Longitudinal studies of young individuals without a prior history of any risk of CVD and who are flourishing or languishing might help provide answers to these questions.
5

Green, Kerrie L. "A descriptive analysis of cardiac rehabilitation education programs." Virtual Press, 2000. http://liblink.bsu.edu/uhtbin/catkey/1177976.

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The purpose of this research was to obtain information on the content of education within cardiac rehabilitation programs, methods of administering education, what the barriers are to providing education and which professionals administer education.To reach this goal, a questionnaire was modified from a previous study and a pilot study was undertaken to establish reliability of the questionnaire. The questionnaire was then sent to a sample of 100 directors of cardiac rehabilitation programs belonging to The American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR). The questionnaire focused on 13 established areas of education within cardiac rehabilitation programs.Once the questionnaires were completed, the information was transferred to a table format based upon the 13 content areas. The following conclusions were drawn from the research and the data gathered: 11 of the 13 content areas are offered at least 84% of the time, the major barriers for the 13 content areas were lack of time and lack of interest on the patient's behalf, the most frequent methods of education for all 13 content areas were individual education, print materials, and group education, and the primary educator overall for all 13 content areas was the nurse followed by the exercise physiologist and dietitian/nutritionist.
Department of Physiology and Health Science
6

Strath, Scott J. "The effect of a light-moderate versus hard exercise intensity on health and fitness benefits." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1115726.

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The purpose of this study was to determine the effect of a light-moderate versus hard exercise intensity on health and fitness benefits in a previously sedentary population. Twenty-six subjects, 17 male (mean age 45 + 3 yrs), 9 female (mean age 48 + 3 yrs) with at least one coronary artery disease risk factor volunteered to participate in this study. Subjects underwent laboratory testing comprising of, resting heart rate and blood pressure, body composition, blood lipid analysis and aerobic capacity (V02 ), prior to and 22-32 weeks after participating > 2 days per week in the Adult Physical Fitness Program (APFP) at Ball State University. After an initial exercise prescription subjects self selected an exercise intensity between 40-80% of their maximal heart rate range (MHRR) at which to train. Subjects were then grouped into those who trained at < 60% (light-moderate) and those who trained at > 60% (hard) of their MHRR.Those that self selected a hard training intensity did show a significantly greater decrease in diastolic blood pressure than the light-moderate intensity group. Subjects received a main training effect with a mean decrease in systolic blood pressure (123 ± 2.8 to 119 ± 2.4 mmHg), diastolic blood pressure (78 ± 2.2 to 75 ± 1.7 mmHg), and mean increases for HDL-cholesterol (49 ± 2.5 to 53 ± 2.8 mg/dL), absolute functional capacity (2.676 +.162 to 2.843 +.169 L/min) and relative functional capacity (30.2 ± 1.5 to 32.8 + 1.8 ml/kg/min). In conclusion this study demonstrated health and fitness benefits when training at least 2 days per week with greater effects when training at a hard versus light-moderate intensity with regards to diastolic blood pressure.
School of Physical Education
7

Bursill, Christina. "Green tea and its catechins modulate cholesterol metabolism in cultured human liver (HepG2) cells and the hypercholesterolaemic rabbit." Title page, contents and introduction only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09pdb9725.pdf.

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Includes bibliographical references (21 leaves). Previous studies have found that green tea and its antitoxidant constituents, the catechins, are hypocholesterolaemic in both epidemiological and animal intervetion studies. The main objectives of the present study were to investigate the mechanism by which green tea and its most abundant catechin constituent epigallocatechin gallate increase the low-density lipoprotein (LDL) receptor of HepG2 cells. In addition, it was hoped to determine if a crude catechin extract from green tea could lower plasma cholesterol levels in the hypercholesterolaemic rabbit and ascertain if this effect was due to an increase in the LDL receptor. The study provides evidence that green tea and its catechins exhibit hypocholesterolaemic properties and may therefore provide protection against heart disease.
8

George, Siddiqah. "A critical analysis of mitochondrial functioning and associated proteins in obesity-related cardiomyopathy." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/80377.

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Thesis (MScMedSc)--Stellenbosch University, 2013.
ENGLISH ABSTRACT: INTRODUCTION: The mechanism behind obesity-related cardiomyopathies is at present not completely known, however, cardiac insulin resistance has been implicated as one of the main arbitrators of obesity-related cardiovascular disease. A few studies have associated perturbations in the insulin-mediated PI3K/PKB/Akt pathway in mediating this insulin resistance. Moreover, this pathway has been shown to regulate myocardial apoptosis, which in turn has been implicated in a number of cardiovascular diseases. Currently, few studies have compared the early onset and advanced effects of obesity on the heart. AIMS: To compare the early and advanced stages of obesity in terms of myocardial (i) PI3K/PKB/Akt signalling, (ii) apoptotic signalling and (iii) mitochondrial integrity. Furthermore, we aim to assess the cardiac mitochondrial (i) PI3K/PKB/Akt signalling, (ii) apoptotic signalling and (iii) integrity during the advanced stages of obesity. METHODS: Male Wistar rats were randomly assigned to either a control or diet-induced obesity (DIO) group. Controls were fed a standard rat chow diet and the DIO group fed a high caloric diet (standard rat chow supplemented with sucrose and condensed milk). The diets were implemented for either 8 or 20 weeks and thereafter, the body weight, intra-peritoneal fat mass, and fasting blood glucose and insulin levels (including intra-peritoneal glucose tolerance tests (IPGTTs)) were determined. Freeze-clamped hearts from both groups were subjected to cytosolic western blot analysis for PI3K p85 subunit, PKB/Akt, GSK-3α/β, Bad, Bax and Bcl-2. A fraction of each heart was also subjected to WB analysis of the mitochondrial electron transport chain (ETC) complexes (I-V). Thereafter, the above mentioned proteins were also probed for in mitochondria isolated from the 20 weeks group after administering insulin and exposing the hearts to ischemia. Oxidative phosphorylation (OXPHOS) capacity analysis was then conducted on mitochondria isolated from 20 weeks DIO and control groups and thereafter a citrate synthase (CS) activity assay was performed on these mitochondria. RESULTS: After the 8 and 20 weeks diet, the DIOs had significantly increased intra-peritoneal fat mass, fasting plasma glucose and insulin levels, compared to their controls. Cytosolic WB analysis: The tp85, pp85 and pPKB/Akt levels were significantly higher in the DIOs in comparison to the controls after 8 weeks of diet. Furthermore, pBad and Bax expression were significantly elevated in these animals. After 20 weeks of diet, the DIOs had significantly decreased pp85, tPKB/Akt and pPKB/Akt levels. The tBad was significantly elevated, while the Bad phosphorylated over total expression (P/T) ratio was significantly decreased, in these animals. CS activity assay: CS activity was significantly decreased in the DIOs, versus the controls, at 20 weeks. Mitochondrial ETC WB analysis: The subunit expression in complexes I-III and V did not differ significantly after 8 weeks however, the expression was significantly lower in complexes I and II after 20 weeks. Interestingly, the complexes III and V expression was significantly elevated. Mitochondrial OXPHOS analysis: The ADP/O ratio with (1) glutamate or (2) palmitoyl-L- carnitine as substrate, showed a significant decrease in the DIOs at 20 weeks. Mitochondrial WB analysis: The pp85 subunit was significantly elevated in the control and DIO groups, exposed to insulin and ischemia, in comparison to the untreated controls. The Bcl-2 levels were significantly decreased in the insulin and ischemia DIOs, when matched against the untreated DIOs. The tBad expression did not differ significantly between the insulin and untreated controls, while the tBad was significantly augmented in the ischemia controls versus untreated controls. All significant differences were taken as p<0.05. CONCLUSION: The results indicate that the initial stage of diet-induced obesity is associated with cardioprotection as there is augmented PI3K/PKB/Akt pathway signalling and a decrease in apoptotic markers. In contrast, during the advanced stages of obesity a decreased activity in PI3K/PKB/Akt pathway is associated with myocardial apoptosis and decreased mitochondrial function and integrity.
AFRIKAANSE OPSOMMING: INLEIDING: Die meganisme verantwoordelik vir vetsug-verwante kardiomiopatieë is huidiglik nie bekend nie maar kardiale insulienweerstandigheid word geïmpliseer as een van die hoof bemiddelaars van vetsug-verwante hartsiektes. Verskeie studies het versteurings in die insulien-gemediëerde PI3K/PKB/Akt pad geassosieer met die bevordering van hierdie insulienweerstandigheid. Daarbenewens is dit getoon dat hierdie pad betrokke is in die regulering van miokardiale apoptose, wat op sy beurt geïmpliseer is in 'n aantal kardiovaskulêre siektes. Daar is tans min studies beskikbaar wat die vroeë en laat gevolge van obesiteit op die hart vergelyk. DOELWITTE: Om die vroeë en gevorderde stadiums van vetsug te vergelyk in terme van miokardiale (i) PI3K/PKB/Akt seintransduksie, (ii) apoptotiese seintransduksie en (iii) mitokondriale integriteit. Verder, het die studie ten doel om die kardiale mitokondriale (i) PI3K/PKB/Akt en (ii) apoptotiese seintransduksie en (iii) integriteit in die gevorderde stadiums van vetsug te bepaal. METODES: Manlike Wistar rotte is ewekansig toegewys aan óf 'n kontrole of dieet-geïnduseerde vetsug (DIO) groep. Kontroles is met 'n normale rotkos dieet en die DIO groep met 'n hoë kalorie dieet (normale rotkos aangevul met sukrose en kondensmelk) gevoed. Die dieet is vir 8 of 20 weke volgehou en daarna was die liggaamsgewig, intra-peritoneale vet massa, en vastende bloed glukose en insulien vlakke (insluitende intra-peritoneale glukose toleransie toets (IPGTT`s)) bepaal. Gevriesklampte harte van beide groepe is onderwerp aan sitosoliese WB-analise vir die PI3K p85 subeenheid, PKB / Akt, GSK-3α/β, Bad, Bax en Bcl-2. `n Fraksie van hierdie harte is ook onderwerp aan westerse klad analise (WK-analise) van die mitokondriale elektron vervoer ketting (EVK) komplekse (I-V). Daarna is bogenoemde proteïene ondersoek in mitokondrieë geïsoleer uit die 20 weke groep ná die toediening van insulien en die blootstelling van die harte aan iskemie. Die oksigraaf mitokondriale oksidatiewe fosforilering (OXPHOS) kapasiteit analise is dan op mitokondrieë van 20 weke DIO en kontrole groepe uitgevoer en daarna is 'n sitraatsintase (SS) aktiwiteitstoets gedoen. RESULTATE: Na die 8 en 20 weke dieet, het die intra-peritoneale vet massa, vastende plasma glukose en insulien vlakke in die DIOs aansienlik toegeneem, in vergelyking met hul kontroles. Sitosoliese WK-analise: Die tp85, pp85 en pPKB/Akt vlakke was beduidend hoër in die DIOs in vergelyking met die kontroles, na 8 weke van die dieet. Verder is die pBad en Bax vlakke beduidend verhoog in hierdie diere. Na 20 weke van die dieet, het die pp85, tPKB/Akt en pPKB/Akt vlakke beduidend afgeneem in die DIOs, in vergelyking met die kontroles. Die tBad was beduidend verhoog, terwyl die Bad verhouding van gefosforileerde oor die totale proteïen uitdrukking (P/T)-verhouding) beduidend verminder het in hierdie diere. SS aktiwiteitstoets: SS aktiwiteit is beduidend verminder in die DIOs, teenoor die kontroles, op 20 weke. Mitokondriale EVK WK-analise: Die subeenheid uitdrukking in komplekse I-III en V was nie beduidend verskillend na 8 weke nie. Na 20 weke egter, was die uitdrukking aansienlik laer in komplekse I en II. Interessant genoeg, is die uitdrukking aansienlik verhoog in komplekse III en V. Mitokondriale OXPHOS analise: Die ADP/O verhouding met (1) glutamaat of (2) palmitiel-L-karnitien as substraat, het beduidend afgeneem in die DIOs teen 20 weke. Mitokondriale WK-analise: Die pp85 subeenheid was beduidend verhoog in die kontrole en DIO groepe, blootgestel aan insulien en iskemie, in vergelyking met die onbehandelde kontroles. Die Bcl-2 vlakke was beduidend verminder in die insulien en isgemie DIOs, in vergelyking met onbehandelde DIOs. Die tBad uitdrukking het nie beduidend verskil tussen die insulien en onbehandelde kontroles nie, terwyl die tBad beduidend verhoog was in die isgemie kontroles versus onbehandelde kontroles. Alle beduidende verskille is geneem as p<0.05. GEVOLGTREKKING: Die resultate dui daarop dat die eerste fase van dieet-geïnduseerde obesiteit geassosieer is met kardiale beskerming want `n toename in PI3K/PKB/Akt seintransduksie en 'n afname in apoptotiese merkers is waargeneem. In teenstelling, in die gevorderde stadium van vetsug is daar 'n afname in aktiwiteit in die PI3K/PKB/Akt pad wat verband hou met verhoogde miokardiale apoptose en verminderde mitokondriale funksie en integriteit.
9

Konicki, Annette Jakubisin. "Women’s Knowledge of Cardiovascular Risk Factors, Level of Self-Nurturance and Participation in Heart-Healthy Behaviors: A Dissertation." Text, eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsn_diss/11.

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The number one killer of women in the United States is cardiovascular disease (CVD). Cardiovascular risk factors (CVRFs) include advancing age, cigarette smoking, diabetes, dyslipidemia, family history, hypertension, obesity, sedentary lifestyle and high intake of saturated fats and low dietary fiber. A women’s risk for development of CVD dramatically increases after menopause and with the number of CVRFs. CVD is often preventable. Evidence supports addressing CVRFs reduction early (in the pre-menopausal years) through heart-healthy behaviors such as increasing physical activity, promoting healthy eating, moderate alcohol consumption and not smoking. Therefore, understanding premenopausal women’s CVRFs knowledge is an important area of inquiry. In addition, the Nemcek Wellness Model suggests that self-nurturance, as well as knowledge, may be an important factor for explaining women’s wellness behaviors. Thus, the purpose of this study was to investigate knowledge of CVRFs, level of self-nurturance and the performance of heart-healthy behaviors in women ages 35 to 55 years. This study used a cross sectional survey design and venue sampling. The survey included demographic questions, the Self Nurturance Survey, the Heart Disease Facts Questionnaire, the Physical Activity Questionnaire, Prime Screen, and questions about financial strain, cigarette smoking, and alcohol use. The sample included 136 women (survey response rate = 57%), the majority of whom were white (94.9%), married (80.1%), did not smoke (80.1%) and rarely drank alcohol (57.4%). Results indicated that study participants were very knowledgeable about CVRFs. (Mean knowledge score = 19.53, possible range = 0 to 25 with higher scores indicating greater knowledge). Knowledge did not predict physical activity (p = .07), diet (p = .08) or smoking status (p = .11) in this sample. Self-nurturance was moderately correlated (r = .33) with consuming a heart-healthy diet. Hypotheses derived from the Nemcek Wellness Model were not supported in this study. More research is needed to identify factors that will help women translate knowledge into heart-healthy behaviors.
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Chau, June, and 周宗欣. "Application of cost-effectiveness concepts to cardiac rehabilitation and secondary prevention in Hong Kong." PG_Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31225755.

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Книги з теми "Heart Diseases Prevention":

1

Nora, James J. Cardiovascular diseases: Genetics, epidemiology, and prevention. New York: Oxford University Press, 1991.

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2

Jackson, Graham. Heart health. 4th ed. London: Class Health, 2009.

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3

Saxena, Shikha. Phytochemicals and heart diseases: Causation and prevention. New Delhi: Mittal Publications, 2011.

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4

Health, Ontario Chief Medical Officer of. Promoting heart health. [Toronto, Ont: The Ministry, 1993.

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5

Jackson, Gordon. The healthy heart. London: Salamander, 1986.

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6

Bennett, Paul. Counselling for heart disease. Leicester: British Psychological Society, 1993.

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7

LaRosa, J. C. Secondary prevention of coronary heart diseases: Altering lioproteins. Amsterdam: Excerpta Medica, 1993.

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8

Kurtzweil, Paula. Helping in preventing heart disease. [Rockville, MD: Dept. of Health and Human Services, Public Health Service, Food and Drug Administration, 1997.

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9

Health, Washington (State) Dept of Health Community and Family. Washington state heart disease and stroke prevention plan. Olympia, WA: The Department, 1995.

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10

Health, Washington (State) Dept of Health Community and Family. Washington State heart disease and stroke prevention plan. Olympia, WA: The Department, 1995.

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Частини книг з теми "Heart Diseases Prevention":

1

de Melo Barbosa, Marcia, Maria do Carmo Pereira Nunes, and Regina Müller. "Rheumatic Heart Disease: A Neglected Heart Disease." In Prevention of Cardiovascular Diseases, 143–57. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22357-5_15.

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2

Puddu, P., and M. Muscari. "Therapy versus prevention of coronary heart disease." In Atherosclerosis and Cardiovascular Diseases, 163–70. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3205-0_20.

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3

Ilkhanoff, Leonard, Alan H. Kadish, and Jason T. Jacobson. "Non-antiarrhythmic Drugs in Sudden Death Prevention." In Electrical Diseases of the Heart, 525–41. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-4978-1_34.

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4

Tung, Patricia, and Peter J. Zimetbaum. "Non-surgical Treatment and Prevention of Atrial Fibrillation." In Electrical Diseases of the Heart, 543–59. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-4978-1_35.

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Kosinski, Andrzej S. "Clinical Trials in Sudden Cardiac Death Prevention: Principles and Endpoints." In Electrical Diseases of the Heart, 487–93. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-4978-1_31.

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Lee, Hon-Chi, and Kristin T. L. Huang. "Clinical Role of Antiarrhythmic Drugs in the Prevention of Sudden Death." In Electrical Diseases of the Heart, 501–24. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-4978-1_33.

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Mastorci, Francesca, Irene Traghella, Laura Sabatino, Alessandro Pingitore, Rudina Ndreu, and Cristina Vassalle. "Oxidative Stress and Cardiovascular Risk and Prevention in Children and Adolescents." In Oxidative Stress in Heart Diseases, 3–18. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8273-4_1.

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8

Nof, Eyal, Michael Glikson, David Luria, Joseph Gard, and Paul A. Friedman. "Beyond Sudden Death Prevention: Minimizing ICD Shocks and Morbidity, and Optimizing Efficacy." In Electrical Diseases of the Heart, 621–47. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-4978-1_40.

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9

Miller, Henry S. "Exercise for Prevention and Treatment of Coronary Heart Disease." In Exercise for Preventing Common Diseases, 69–73. Tokyo: Springer Japan, 1999. http://dx.doi.org/10.1007/978-4-431-68511-1_9.

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Epstein, F. H. "Prevention of coronary heart disease - links with other chronic disorders." In Atherosclerosis and Cardiovascular Diseases, 157–62. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3205-0_19.

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Тези доповідей конференцій з теми "Heart Diseases Prevention":

1

Barbey, Alex, and Frano Mika. "Prevention of Heart Attacks and Other Cardiovascular Diseases in the Oil and Gas Industry." In SPE International Conference on Health, Safety, and Environment. Society of Petroleum Engineers, 2014. http://dx.doi.org/10.2118/168311-ms.

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2

Poniewierski, M., M. Barthels, and H. Poliwoda. "THE SAFETY AND EFFICACY OF A LOW MOLECULAR WEIGHT HEPARIN (FRAGMIN) IN THE PREVENTION OF DEEP VEIN THROMBOSIS IN MEDICAL PATIENTS: A RANDOMIZED DOUBLE-BLIND TRIAL." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643224.

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The safety and efficacy of 2500 anti-Factor Xa U of a low molecular weight heparin (Kabi 2165, Fragmin) subcutaneously once a day, and 5000 IU of standard unfractionated Heparin (KabiVitrum, Stockholm) subcutaneously twice daily as thromboprophylaxis was compared in 200 medical patients in a randomized double blind trial. According to the risk of DVT the patients were stratified before randomization in a high and low risk group. The high risk group consisted of 100 patients mainly with malignant diseases and/or previous history of thromboembolism, the low risk group of 100 patients with mainly myocardial infarction and/or coronary heart disease. The prophylaxis was given for seven to ten days. In 192 consecutive patients the clinical status and thermographic screening for DVT (leg temperature profiles, DeVeTherm) were daily evaluated. In two cases of suspected DVT and one case of suspected PE, the following phlebography or pulmonary scintigraphy were found to be negative. In the high risk group, one patient treated with Fragmin having a central venous catheter developed on day 10 symptoms of an arm vein thrombosis. There were no bleeding complications observed in either of the two treatment groups. Two patients with trombocytopenia (25.000 and 22.000/pl) due to chemotherapy and underlying malignant disease were successfully treated with Fragmin without developing any bleeding complications. In eight patients during Fragmin prophylaxis invasive diagnostic methods as heart catheterization, gastroscopy, bronchoscopy or spinal puncture were performed without noticing any bleeding events. 2500 anti-Factor Xa U of Fragmin gave plasma levels by anti-Factor Xa assay (S-2222, Kabi) of mean 0,1 U/ml when blood was sampled three to four hours after the subcutaneus application. There was no accumulation during the treatment periode observed.This study suggests that 2500 anti-Factor Xa U of Fragmin once daily is as safe and effective as 5000 IU of standard heparin twice daily in these medical patients. Especially in patients who need prophylaxis for a long time eg. with malignant disease, the once daily injection is welcomed.
3

Babalola, R. O., O. A. Fagade, and P. A. AJAYI. "Heart Disease Prevention In The Workplace: A Case Study." In SPE International Conference on Health, Safety and Environment in Oil and Gas Exploration and Production. Society of Petroleum Engineers, 2000. http://dx.doi.org/10.2118/61022-ms.

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4

C., Sujatha, and Anitha R. "Preventing Heart Disease and Stroke in Cardiovascular Diabetics." In International Conference on Computer Applications — Computer Applications - I. Singapore: Research Publishing Services, 2010. http://dx.doi.org/10.3850/978-981-08-7618-0_1464.

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5

Al-Salamah, Mashail, and Saad Amin. "Heart Disease Diagnosis Using Reconstructive Radial Basis Function Networks with Overlapping Prevention Method." In 5th EAI International Conference on Wireless Mobile Communication and Healthcare - "Transforming healthcare through innovations in mobile and wireless technologies". ICST, 2015. http://dx.doi.org/10.4108/eai.14-10-2015.2261993.

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6

Asmare, Melkamu, Frehiwot Woldehanna, Luc Janssens, and Bart Vanrumste. "Automated Rheumatic Heart Disease Detection from Phonocardiogram in Cardiology Ward." In Special Session on Machine Learning and Deep Learning Improve Preventive and Personalized Healthcare. SCITEPRESS - Science and Technology Publications, 2020. http://dx.doi.org/10.5220/0009367108390844.

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7

Mehta, Dhara B., and Nirali C. Varnagar. "Newfangled Approach for Early Detection and Prevention of Ischemic Heart Disease using Data Mining." In 2019 3rd International Conference on Trends in Electronics and Informatics (ICOEI). IEEE, 2019. http://dx.doi.org/10.1109/icoei.2019.8862544.

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8

Yap, Choon Hwai, Laksmi Prasad Dasi, Roy Junius Rusly, and Ajit P. Yoganathan. "Dynamics of the Aortic Valve Under Normal, Flow Rate-Varied and Heart Rate-Varied Conditions: An In Vitro Study." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192935.

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Aortic valve (AV) disease caused by calcific stenosis is one of the major causes of cardiac related deaths around the world. Studies indicate that abnormal hemodynamics and structural stress fields experienced by the valve leaflets could cause tissue inflammation, which could lead to leaflet calcification and sclerosis [1,2]. However, the mechanics and dynamic properties of the aortic valve under various hemodynamic conditions have not been fully characterized, preventing us from further investigation of this link between mechanics and valve pathology.
9

Erzhen, Zen, Lu Yung-Cai, Wang Jain, Shi Fang, Lia Xiaoqing, Zhou Yulin, Jia Xudong, and Gou Zhaozheng. "EXPERIMENTAL STUDIES ON THE MECHANISM OF CHINESE MEDICINAL RHAPONTICUM UNIFLORUM DC IN PREVENTING CORONARY HEART DISEASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643029.

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The mechanism of Rhaponticum Uniflorum DC in preventing coronary heart disease was studied in vivo and in vitro. TBA fluorescent method was used to determine lipid peroxides (Lpo) and double analysis method was used to determine glutathione peroxidase (GSH-Px) activity and fluorescent polarization of DPH probed membrane fluidity of smooth muscle cell (SMC).Rabbits were fed with high fat diet for 120 days. At the end of experiment, all the animals acquired hyperlipidemia and developed atheroma lesions in aorta and/or coronary. It was found that hyperlipidemia caused a rising of Lpo in blood (from 2.6±0.56 in control up to 8.48±3.28 nmol/ml) and in arterial wall (from 6.75±0.59 in control up to 31.94±4.20 nmol/g protein) and a decreasing of GSH-Px activity in arterial wall (from 0.210±0.095 down to 0.056±0.026 EU/g protein); concomitantly, an increase in microviscosity of arterial SMC membrane (from 1.93±0.04 in control up to 3.49±0.92 poise) which reflects a decrease in fluidity of SMC membrane. Lpo level was higher in plaque area (113.70±46.14 nmol/g protein) than in non-plaque area (58.32±12.69 nmol/g protein). GSH-Px activity level was lower in plaque area (0.0052±0.0014 EU/g protein) than in non-plaque area (0.015+0.0014 EU/g protein). Microviscosity of SMC membrane was higher in plaque area (2.92±0.35 poise) than in non-plaque area (2.26±0.24 poise, p<0.02). By comparison, the rabbits received Rhaponticum Uniflorum DC and VE showed much lowering of Lpo level in arterial wall (down to 10.74±1.61 and 9.93±1.17 nmol/g protein) and decreasing of microviscosity (down to 2.05+0.45 and 2.08+0.50 poise) that is increasing of membrane fluidity of arterial SMC membrane, but GSH-Px activity in arterial wall was keeping at lower level (0.036±0.027 and 0.051±0.027 EU/g protein). The atheroma lesions develped in these two group animals were less severe and fewer in number.
10

Masithulela, Fulufhelo. "The Effect of Over-Loaded Right Ventricle During Passive Filling in Rat Heart: A Biventricular Finite Element Model." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-50004.

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The physiological basis of the right ventricle diastolic function is not well studied. In most heart failure, heart transplantation remains the first choice with survival ranges between 40% and 50%. It is known that heart transplantation lacks donors and therefore, there is a need to search for new surgical techniques for heart failure prevention. This study utilized the finite elment method to study the structural behavior of heart wall under severe pressures. In this study the effect RV filling during over-pressurised RV using bi-ventricular model has been studied using finite element modeling (FEM). Cardiovascular disease (CVD) is the leading cause of death in low-income and middle-income countries. The right ventricle (RV) dysfunction is understood to have an impact on the performance of the left ventricle (LV) but the mechanisms remain poorly understood. Finite strain analyses of bi-ventricular model provide important information on the heart function. The passive myocardium was modelled as a nearly incompressible, hyperelastic, transversely isotropic material. Biventricular geometries of healthy and infarcted rat hearts reconstructed from magnetic resonance images were imported in Abaqus©. In simulating the passive filling of the healthy condition of the rat heart, the inner walls of the LV and RV the pressures of 4.8 kPa and 0.0098 kPa were applied respectively. The average circumferential strain was found to be 0.138 and 0.100 on the endocardium of the over-pressured and healthy model respectively. The high stresses and strains on the over-loaded model were observed.

Звіти організацій з теми "Heart Diseases Prevention":

1

Treadwell, Jonathan R., James T. Reston, Benjamin Rouse, Joann Fontanarosa, Neha Patel, and Nikhil K. Mull. Automated-Entry Patient-Generated Health Data for Chronic Conditions: The Evidence on Health Outcomes. Agency for Healthcare Research and Quality (AHRQ), March 2021. http://dx.doi.org/10.23970/ahrqepctb38.

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Background. Automated-entry consumer devices that collect and transmit patient-generated health data (PGHD) are being evaluated as potential tools to aid in the management of chronic diseases. The need exists to evaluate the evidence regarding consumer PGHD technologies, particularly for devices that have not gone through Food and Drug Administration evaluation. Purpose. To summarize the research related to automated-entry consumer health technologies that provide PGHD for the prevention or management of 11 chronic diseases. Methods. The project scope was determined through discussions with Key Informants. We searched MEDLINE and EMBASE (via EMBASE.com), In-Process MEDLINE and PubMed unique content (via PubMed.gov), and the Cochrane Database of Systematic Reviews for systematic reviews or controlled trials. We also searched ClinicalTrials.gov for ongoing studies. We assessed risk of bias and extracted data on health outcomes, surrogate outcomes, usability, sustainability, cost-effectiveness outcomes (quantifying the tradeoffs between health effects and cost), process outcomes, and other characteristics related to PGHD technologies. For isolated effects on health outcomes, we classified the results in one of four categories: (1) likely no effect, (2) unclear, (3) possible positive effect, or (4) likely positive effect. When we categorized the data as “unclear” based solely on health outcomes, we then examined and classified surrogate outcomes for that particular clinical condition. Findings. We identified 114 unique studies that met inclusion criteria. The largest number of studies addressed patients with hypertension (51 studies) and obesity (43 studies). Eighty-four trials used a single PGHD device, 23 used 2 PGHD devices, and the other 7 used 3 or more PGHD devices. Pedometers, blood pressure (BP) monitors, and scales were commonly used in the same studies. Overall, we found a “possible positive effect” of PGHD interventions on health outcomes for coronary artery disease, heart failure, and asthma. For obesity, we rated the health outcomes as unclear, and the surrogate outcomes (body mass index/weight) as likely no effect. For hypertension, we rated the health outcomes as unclear, and the surrogate outcomes (systolic BP/diastolic BP) as possible positive effect. For cardiac arrhythmias or conduction abnormalities we rated the health outcomes as unclear and the surrogate outcome (time to arrhythmia detection) as likely positive effect. The findings were “unclear” regarding PGHD interventions for diabetes prevention, sleep apnea, stroke, Parkinson’s disease, and chronic obstructive pulmonary disease. Most studies did not report harms related to PGHD interventions; the relatively few harms reported were minor and transient, with event rates usually comparable to harms in the control groups. Few studies reported cost-effectiveness analyses, and only for PGHD interventions for hypertension, coronary artery disease, and chronic obstructive pulmonary disease; the findings were variable across different chronic conditions and devices. Patient adherence to PGHD interventions was highly variable across studies, but patient acceptance/satisfaction and usability was generally fair to good. However, device engineers independently evaluated consumer wearable and handheld BP monitors and considered the user experience to be poor, while their assessment of smartphone-based electrocardiogram monitors found the user experience to be good. Student volunteers involved in device usability testing of the Weight Watchers Online app found it well-designed and relatively easy to use. Implications. Multiple randomized controlled trials (RCTs) have evaluated some PGHD technologies (e.g., pedometers, scales, BP monitors), particularly for obesity and hypertension, but health outcomes were generally underreported. We found evidence suggesting a possible positive effect of PGHD interventions on health outcomes for four chronic conditions. Lack of reporting of health outcomes and insufficient statistical power to assess these outcomes were the main reasons for “unclear” ratings. The majority of studies on PGHD technologies still focus on non-health-related outcomes. Future RCTs should focus on measurement of health outcomes. Furthermore, future RCTs should be designed to isolate the effect of the PGHD intervention from other components in a multicomponent intervention.
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Gindi, Renee. Health, United States, 2019. Centers for Disease Control and Prevention (U.S.), 2021. http://dx.doi.org/10.15620/cdc:100685.

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Health, United States, 2019 is the 43rd report on the health status of the nation and is submitted by the Secretary of the Department of Health and Human Services to the President and the Congress of the United States in compliance with Section 308 of the Public Health Service Act. This report was compiled by the National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention (CDC). The Health, United States series presents an annual overview of national trends in key health indicators. The 2019 report presents trends and current information on selected measures of morbidity, mortality, health care utilization and access, health risk factors, prevention, health insurance, and personal health care expenditures in a 20-figure chartbook. The Health, United States, 2019 Chartbook is supplemented by several other products including Trend Tables, an At-a-Glance table, and Appendixes available for download on the Health, United States website at: https://www.cdc.gov/nchs/hus/ index.htm. The Health, United States, 2019 Chartbook contains 20 figures and 20 tables on health and health care in the United States. Examining trends in health informs the development, implementation, and evaluation of health policies and programs. The first section (Figures 1–13) focuses on health status and determinants: life expectancy, infant mortality, selected causes of death, overdose deaths, suicide, maternal mortality, teen births, preterm births, use of tobacco products, asthma, hypertension, heart disease and cancer, and functional limitations. The second section (Figures 14–15) presents trends in health care utilization: use of mammography and colorectal tests and unmet medical needs. The third section (Figures 16–17) focuses on health care resources: availability of physicians and dentists. The fourth section (Figures 18–20) describes trends in personal health care expenditures, health insurance coverage, and supplemental insurance coverage among Medicare beneficiaries. The Highlights section summarizes major findings from the Chartbook. Suggested citation: National Center for Health Statistics. Health, United States, 2019. Hyattsville, MD. 2021.

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