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Дисертації з теми "Metastasis"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Wander, Seth A. "p27 and Metastatic Progression: Molecular Mechanisms Underlying Bone Metastasis." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/690.

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The complex PI3K/mTOR pathway regulates tumor progression via effects on cellular proliferation, apoptosis, autophagy, and motility. New drugs that inhibit the catalytic site of both PI3K and mTOR have shown promise in clinical trials. Here, we report the first use of a novel, dual PI3K/mTOR catalytic site inhibitor (PF-04691502, PF1502) in a xenograft model of breast cancer metastasis to bone. Metastatic MDA-MB-1833 cells showed PI3K/mTOR activation relative to parental MDA-MB-231. Low-dose PF1502 significantly impaired tumor cell motility and invasion in vitro without causing cell cycle arre

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2

Björndahl, Meit A. "Lymphangiogenesis and lymphatic metastasis /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-562-3/.

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3

Chiang, Yan Ting. "Identification of metastasis-driving genes as potential therapeutic targets/ biomarkers for metastatic prostate cancer." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52901.

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Metastatic prostate cancer is currently incurable. Metastasis is thought to result from changes in the expression of specific metastasis-driving genes, leading to a cascade of activated downstream genes setting the metastatic process in motion. As such, metastasis-driving genes could provide effective therapeutic targets and prognostic biomarkers for improved disease management. In search of potential metastasis-driving genes, genes with elevated expression in patient-derived metastatic LTL-313H prostate cancer tissues, as distinct from non-metastatic LTL-313B tissues, were identified. Among t

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4

Nielsen, S. R. "Metastasis-associated macrophages orchestrate the formation of a hospitable metastatic niche in pancreatic cancer." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3007527/.

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with an overall 5-year survival rate < 5%, a rate that has not improved for a long time. The dismal prognosis for PDAC is part due to late detection, often at advanced stages of the disease where patients have developed distant metastases, but also due to chemotherapeutical resistance. Patients eligible for surgical resection of the pancreatic tumour has the best prognosis, but even when resection is successful, patients often relapse with distant metastases within 2 years after surgery. Macrophages promote tumourigenesi

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5

Yuzhalin, Arseniy. "Proteomic profiling of metastatic matrisome reveals citrullination as a marker of colorectal liver metastasis." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:2612ba4b-b311-4802-84ae-ab60472bfe02.

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Colorectal cancer is one of the most frequently occurring malignancies and a major cause of cancer death. Distant metastases in this disease most commonly develop in the liver and are often untreatable. Here, we use proteomics to characterise, qualitatively and quantitatively, extracellular matrix (ECM) from colorectal cancer liver metastases. We show that citrullination of the ECM by cancer cell derived peptidyl arginine deiminase 4 (PAD4) is important for the growth of liver metastases. Citrullination of proteins, a posttranslational conversion of arginine residues to citrulline, is well rec

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6

Stitzlein, Russell Neil. "The role of ezrin in osteosarcoma metastasis and its potential use in early identification of metastases." Miami University Honors Theses / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1177692826.

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7

Clark, S. R. "The investigation of tumour metastasis." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370241.

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8

Liu, Hui Ph D. Massachusetts Institute of Technology. "Identification of a novel metastasis enhancer, CDCP1, and analysis of its functions during melanoma metastasis." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/47881.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2009.<br>Includes bibliographical references.<br>Nearly 90% of cancer mortality from solid tumors is due to metastasis of malignant cells to the distant vital organs. It is now well established that a plethora of stromal cells are present within the tumor, and contribute in various ways to tumor initiation and progression, and plasma membrane proteins are the mediators for tumor-stromal communications. In this thesis, I focused on plasma membrane proteins that may contribute to tumor metastasis. I applied quantitative ma

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9

Onder, Tamer T. "Role of e-cadherin in tumor metastasis and discovery of compounds targeting metastasis cancer cells." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43226.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2008.<br>Includes bibliographical references.<br>The epithelial cell adhesion molecule E-cadherin is often downregulated during carcinoma progression and metastatic spread of tumors. However, the precise mechanism and molecular basis of metastasis promotion by E-cadherin loss is not completely understood. To investigate its role in metastasis, I utilized two distinct methods of E-cadherin inhibition that distinguish between E-cadherin's cell-cell adhesion and intracellular signaling functions. While the disruption of cel

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10

Gooding, Alex Joseph. "Characterizing a Role for the lncRNA BORG during Breast Cancer Progression and Metastasis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1528462540265762.

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11

Garcia, López Marta. "Experimental Models of Prostate Cancer Bone Metastasis - Establishment, characterization and imaging of xenograft bone metastasis models -." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/120182.

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En païssos industrialitzats, el càncer de pròstata (CP) és la neoplasia més comunment diagnosticada en homes i la segona causa de mort relacionada amb càncer, donat que els nivells de mortalitat en aquesta població són molt més baixos que els que es troben en els païssos en desenvolupament, es veu un clar benefici en els avenços tant en el diagnòstic precoç com el desenvolupament de teràpies eficients. No obstant, la disseminació metastàtica més que el tumor primari en sí és la responsable dels problemes de mortalitat i morbiditat associats al CP. Les metàstasis esquelètiques estan presents en

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12

Bellmunt, i. Tarragó Anna. "Role of MAF in bone metastasis." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/482079.

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The identification of genes that mediate metastasis is pivotal to better understand the mechanism, to develop novel drugs and to stratify patients with highest risk and consecutively administrate them preventive treatments. Despite significant advances on knowledge, diagnosis and treatment of cancer, metastasis remains the major cause of cancer-associated deaths. Bone is one of the most common organs affected by metastatic lesions for its permeability and favorable conditions for cellular growth. Constant remodeling in bone homeostasis implies an incessant degradation of the bone that relea

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13

Swofford, Brenen P., and Tomislav Dragovich. "Sigmoid Adenocarcinoma with Regional Scrotal Metastasis." KARGER, 2017. http://hdl.handle.net/10150/625839.

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Colorectal cancer is a common disease, representing the third and second most common cause of cancer death in the United States in women and men, respectively. [Ahnen et al.: Mayo Clin Proc 2014;89:216-224; Siegel et al.: CA Cancer J Clin 2016;66:7]. It is estimated that 20% of patients have distant metastatic disease at time of diagnosis [Ahnen et al.: Mayo Clin Proc 2014;89:216-224; Siegel et al.: CA Cancer J Clin 2016;66:7]. The most common metastatic sites include regional lymph nodes, liver, lungs, and peritoneum via lymphatic/hematogenous dissemination as well as contiguous and transperi

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14

Weigelt, Britta. "Molecular markers of breast cancer metastasis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2005. http://dare.uva.nl/document/88848.

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15

Park, Se Hyung. "Estrogen in ovarian cancer cell metastasis." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1287.

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Benign ovarian tumors and majority of epithelial ovarian cancers possess steroid receptors including estrogen receptors (ERs). However, the estrogen-ER signaling in ovarian carcinomas is not completely understood. Tumorigenesis is a multiple-step process involving dysregulated cell growth and metastasis. Tumor cells acquire the capacity of migration and invasion by temporal phenotypical and genotypical changes termed epithelial-mesenchymal transition (EMT). Considerable evidence implicates a mitogenic action of estrogen in early ovarian carcinogenesis. In contrast, its influence in the metasta

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16

Fawcett, Jonathan. "Molecular aspects of angiogenesis and metastasis." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386753.

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17

Lanati, Silvia. "Chemokine-mediated metastasis in malignant melanoma." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654112.

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Malignant melanoma is the most lethal form of skin cancer due to the metastatic spread of the disease. Chemokines have been shown to play a key role in the metastatic cascade. The chemokine receptor CCR7 and its ligand CCL21 were shown to be involved in migration of CCR7 expressing melanoma cells towards a gradient of CCL21 released by lymphatic endothelial cells (LEC) and promote metastasis at the draining lymph node (LN) in in vivo tumour models. I therefore tested the hypothesis that growth of CCR7 -expressing tumours towards LEC is CCL21-dependent in vivo, that LECs promoted this growth th

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18

Woolgar, Julia Anne. "Lymph node metastasis in oral cancer." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260368.

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19

Knight, C. Rosamund L. "Transglutaminase activity, tumour growth and metastasis." Thesis, Nottingham Trent University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278115.

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20

Benjamin, David Colin. "Intravital imaging of metastasis in zebrafish." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/117867.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2018.<br>DVD-ROM contains: movies/videos.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Metastasis is the cause of the overwhelming majority of cancer deaths. However, it remains a poorly understood process. The events at the metastatic site are especially poorly comprehended. These events are dynamic and so require intravital imaging to investigate. However, the intravital imaging of these events in mice is challenging. Sites of metastasis are often in vital organs that are inac

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21

Ferjancic, Spela. "Endothelial activation in experimental metastasis models." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:14ecdd1d-0acb-458a-b11e-6543779b2a2f.

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The majority of cancer related deaths occur due to the invasive growth of metastatic lesions. In the early stages of metastasis, circulating cell interact with the endothelial cells to establish at a distant site. In inflammation endothelial activation results in induction of adhesion molecules on the endothelium that participate in the homing of leukocytes. Because of the interactions of metastatic cells with the endothelium, the question was whether some of the characteristic molecules of endothelial activation were induced during metastasis. In vivo pulmonary metastatic models were used to

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22

Pietschmann, Sophie. "Charakteristika, Therapie und Prognose von Patienten mit metastasierten WHO Grad IV Gliomen - Eine Metaanalyse individueller Patientendaten." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-216728.

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Da hochgradige Gliome nur eine geringe Tendenz zur Metastasierung aufweisen, beschränkte sich das klinische Wissen über diesen seltenen Krankheitsverlauf bisher im Wesentlichen auf die Erkenntnisse aus Einzelfallberichten und kleineren Fallserien. Eine detaillierte Analyse der beschriebenen Fälle war bisher nicht verfügbar. Die vorliegende Arbeit stellt eine systematische Auswertung der wissenschaftlichen Literatur über Patienten mit metastasierten Glioblastomen oder Gliosarkomen dar. Unser Ziel war es, sämtliche Publikationen zu berücksichtigen, welche bis April 2013 veröffentlicht worden si

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23

Lee, Lennard. "Driver genes for metastasis of colorectal cancer." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:540e096f-b30c-4dc7-8697-7bba1304d61a.

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Cancer metastasis is the principal cause of death in patients with solid organ tumours. Once cancer has spread, it is generally considered incurable. This spread of cells from the primary tumour to distant sites (metastasis) is a complex process and this DPhil focuses on colorectal cancer (CRC) metastasis. It has three aims; the development of a new CRC metastasis model, the completion of a whole-genome screen for drivers of metastasis and the development of a greater understanding of the molecular drivers of metastasis through use of human lymph node metastasis (LNM) samples. The new CRC meta

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24

O'Brien, Emma Rosemary. "The role of astrocytes in brain metastasis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:60efc7bd-4f00-4e84-a964-c4ef55009dfb.

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25

Oosterhout, Anselmus Gerardus Maria van. "Small cell lung cancer and brain metastasis." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=6643.

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26

LeBedis, Christina. "Lymph node involvement in breast carcinoma metastasis." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31255.

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Since lymph node stromal cells remain largely uncharacterized with respect to cell surface markers and function, their role in regulating the growth and invasion of disseminated cancer cells, including breast carcinoma has, to date, been virtually unexplored. In the present study, we asked whether peripheral lymph node cells could modulate the growth of breast carcinoma cells and, thereby, contribute to the progression of the metastatic process. Primary cultures of rat peripheral lymph node stromal cells were obtained by limiting dilution and two sublines, STA4 and STB12, with breast carcinoma

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27

Mourskaia, Anna. "Molecular mediators of breast cancer bone metastasis." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114138.

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Breast cancer is the most frequently diagnosed and the second leading cause of cancer deaths in Canadian women. The most devastating and deadly feature of the disease is the emergence of metastases. Breast cancer most commonly metastasizes to bone, often leading to a significantly decreased quality of life in affected patients. Despite progress in understanding the underlying molecular biology of breast tumors that relapse to bone, to date there are no therapies capable of curing the disease. Hence, it is essential to gain a more in-depth knowledge of the molecular mechanisms that underlie the

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28

吳曉靑 and Xiaoqing Wu. "Post-radiotherapy cervical metastasis in nasopharyngeal carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31222018.

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29

Bista, Bigyan R. (Bigyan Raj). "Adhesion-GPCRs in cancer progression and metastasis." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104169.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2016.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Adhesion-GPCRs, a novel family of G protein-coupled receptors (GPCRs), are characterized by an extended extracellular region linked to a seven-pass transmembrane moiety via GPCR proteolytic site (GPS)-containing stalk region known as GAIN domain. The name adhesion refers to the presence of functional domains in the extracellular region that commonly mediate cell-cell and cell-matrix interactions in various cont

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30

Keeton, Shirley. "An integrated approach to modelling cancer metastasis." Thesis, University of Reading, 2016. http://centaur.reading.ac.uk/68648/.

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The spread of cancer to distant sites, metastasis, is responsible for the majority of cancer related deaths. Metastasis is a complex process comprising a number of steps and mechanisms which take place over time. Due to the temporal and extemperaneous nature of metastasis it has proved difficult to study. Current models are limited in their application and there is a need to develop new models which provide a better and more meaningful biological context for the study of metastasis. Taking a tissue engineering approach, this project has sought to develop a set of in vitro models for the explor

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31

Bayles, Ian Matthew. "SCREENING FOR EPIGENETIC INHIBITORS OF OSTEOSARCOMA METASTASIS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1579859055599871.

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32

Wu, Xiaoqing. "Post-radiotherapy cervical metastasis in nasopharyngeal carcinoma /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20843252.

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33

Lopez, Jose Ignacio. "CD44 Attenuates Metastasis During Breast Cancer Progression." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/193882.

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Progression to metastatic disease is the leading cause of deaths resulting from breast cancer. Understanding the mechanisms underlying a cell's ability to move away from its site of origin and populate a distant site is important for the future development of therapies. The interactions between a tumor cell and the microenvironment can modulate a cell's ability to invade through tissues and access distant organs. In this study we present evidence indicating the differential modulation of invasive and proliferative phenotypes by hyaluronan present in the cellular microenvironment.We establis

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34

Mehrotra, Swarna. "IAP Regulation of Tumor Metastasis: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/437.

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The dissemination of tumor cells to distant organs i.e. metastasis is an exceedingly complex process leading to 90% of all cancer deaths. Despite being so clinically important, little is known about this process that requires tumor cells to leave the primary tumor site, intravasate and transport through the blood stream, extravasate and colonize at secondary sites leading to distant metastases. Survivin, a member of the IAP (Inhibitor of Apoptosis) family with known functions in apoptosis and mitosis, is highly expressed in aggressive tumors and is associated with poor prognosis and adverse cl

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35

Harihar, Sitaram. "The Role of Phosphoinositide Signaling in Breast Cancer Metastasis Suppressor 1-Mediated Metastasis Suppression of Human Breast Carcinoma Cells." DigitalCommons@USU, 2011. https://digitalcommons.usu.edu/etd/870.

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Breast cancer is the most common non-skin cancer in women and the second most common cause of cancer-related death in U.S. women. Despite numerous advances in treatment strategies against breast cancer, the presence of undetected distant metastasis of the primary tumor remains the main cause of mortality. Current screening and detection methods such as mammograms are simply not sensitive enough to detect formation of metastasis. Further, currently available therapies against metastatic breast cancer do not provide a complete cure for the disease. Thus, understanding the biology and molecular f

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36

Billström, Anita. "The significance of urokinase-type plasminogen activator (u-PA) in tumour growth and linomide-induced upregulation of u-PA's endogenous inhibitor PAI-2." Lund : Research Laboratory, Dept. of Obstetrics and Gynaecology, Lund University Hospital, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39751812.html.

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37

Texler, Michael Lutz. "Aetiology of tumour cell movement during laparoscopic surgery : patterns of movement and influencing factors." Title page, table of contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09MD/09mdt355.pdf.

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Accompanying CD-ROM contains image files and software. Bibliography: leaves 259-286. Explores the factors affecting the movement of tumour cells from a primary malignancy across the peritoneal cavity to the port-site following laparoscopic intervention. Filter methods and radio-labelled tumour cells provided the most useful way of following cell movement. Concludes spread of tumour cells to the port-site is more likely in the presence of disseminated disease, as well as with inappropriate surgical technique. Metastasis may be reduced by the use of intraperitoneal lavage and appropriate surgica

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38

Zaimenko, Inna. "Molecular and metabolic determinants of metastasis development and progression." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19078.

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MACC1, ein Hauptregulator von Metastasen, ist an zahlreichen Kennzeichen von Krebs beteiligt, einschließlich dereguliertem Metabolismus. Dennoch ist seine Rolle im Krebsstoffwechsel unklar. In der vorliegenden Arbeit wurde eine systematische Analyse von MACC1-getriebenen metabolischen Netzwerken durchgeführt. MACC1 erhöhte die GLUT1 auf Zellmembrane, was zu einer erhöhten Glukoseanreicherung, einem erhöhten Glukosefluss und somit zu einer erhöhten Zellproliferation führte. Außerdem, reduzierte MACC1 den Glutaminfluss unabhängig von der Nährstoffverfügbarkeit. Bei Glucoseentzug erhöhte MACC1 di

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39

García, de Albéniz Xabier. "Mechanisms of invasion and metastasis in colorectal cancer." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/300900.

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We studied the mechanisms driving the metastatic spread in colorectal cancer (CRC), focusing in the MAPK pathway. We developed in vivo a highly metastatic cell line using a KRAS-mutated cell line (SW620) in an ortothopic xenograft mouse model and used both in vivo and in vitro experiments to evaluate the mechanisms of metastasis. We also used data from two large prospective cohorts of incident CRC to evaluate the association of an intronic variant of SMAD7 (rs4939827, 18q21) with the phenotype and molecular characterisitics of CRC. In the first project, we inoculated SW620 luciferase-expres

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40

Winkelmann, Christopher Todd. "Micro-imaging characterization of mouse models of metastasis." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/5820.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2005.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "December 2005" Includes bibliographical references.

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41

Ahn, Jessica Jung Min. "Molecular mechanisms of NEDD9, a melanoma metastasis gene." Thesis, Institute of Cancer Research (University Of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543775.

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42

Dye, Danielle E. "The role of MCAM in melanoma and metastasis." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0207.

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[Truncated abstract] Melanoma cell adhesion molecule (MCAM) is highly expressed in more than 70% of metastatic melanoma and is correlated with invasive potential. However, the specific contribution MCAM makes to invasion and metastasis in melanoma is not clear. In this study, I have demonstrated that transfection of MCAM into MCAM-negative melanoma and CHO cells leads to changes in cell shape, and the modulation of cell-to-cell and cell-matrix interactions. MCAM positive cells were slower to spread on collagen type I, collagen type IV and laminin 1 than MCAM negative cells, although these diff

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43

Lin, Dong. "Identification of metastasis-associated genes in prostate cancer." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/24145.

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Metastasis is thought to be based on genetic and epigenetic alterations. The mechanisms underlying prostate cancer metastasis are not clear. Studies aimed at identifying genes with key roles in this process have been impeded by lack of clinically relevant models. The heterogeneity of primary prostate cancer specimens from patients, consisting of non-metastatic and metastatic subpopulations, hampers identification of metastasis-associated genes by direct comparison of primary and secondary cancers. To overcome such hurdles, metastatic and non-metastatic tumor sublines have been developed from o

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44

Clark, Richard R. "Lymph node metastasis in auricular squamous cell carcinoma." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/547/.

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Introduction Squamous cell carcinoma of the auricle has an unusually high rate of lymph node metastases when compared to similar tumours at other sites. The lymph nodes affected are close to the base of the skull and in the neck. Development of metastasis carries a poor prognosis and most patients will subsequently die of failure of loco-regional control. Despite the likelihood of a poor outcome nothing can be done for patients prior to development of metastasis, as the risk of spread is not sufficiently high to warrant intervention in all patients. They are therefore treated with a ‘wait and

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45

Clarke, Philip. "Hormonal control of gastrointestinal cancer : relationship to metastasis." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401041.

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46

Cunnick, Giles Harvey. "Lymphangiogenesis and lymphatic metastasis in human breast cancer." Thesis, St George's, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399219.

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47

Frew, Sarah Elizabeth Ann 1976. "Investigation of the role of IQGAP1 in metastasis." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/27045.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.<br>Includes bibliographical references (leaves 108-124).<br>Metastasis, or the spread of a primary tumor to distal sites in the body, is the major cause of human cancer-related morbidity and mortality. Metastasis requires a complex series of cellular events that remain poorly understood at the molecular level. Recently, advances in microarray technology have allowed cancer biologists to globally survey metastatic progression and define patterns of gene expression that correlate with progression to a metastatic phen

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48

Benaich, Nathan. "MicroRNA modulators of head and neck cancer metastasis." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648432.

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Dias, Liliana Mendonça da Silva. "The role of endothelial Dll4 in cancer metastasis." Doctoral thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2019. http://hdl.handle.net/10400.5/19600.

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Tese de Doutoramento em Ciências Veterinárias, especialidade de Ciências biológicas e biomédicas<br>The metastatic spread of cancer is still the major barrier to the treatment of this disease. Cancer-mortality is mainly due to recurrence and metastasis. Although much has been done in the field of cancer treatment, prevention and approach to metastases are still areas not fully explored. Over and under-expression of Dll4/Notch signaling has been demonstrated to impair tumor growth through opposing patterns of vascular modulation in different mouse tumor models and human cancer xenografts.

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Simmons, Jessica Kelly. "Models and Mechanisms of Prostate Cancer Bone Metastasis." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397636660.

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