Статті в журналах з теми "Personalised offers"
Щоб переглянути інші типи публікацій з цієї теми, перейдіть за посиланням: Personalised offers.
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 статей у журналах для дослідження на тему "Personalised offers".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте статті в журналах для різних дисциплін та оформлюйте правильно вашу бібліографію.
1
Sanderson, James, and Nicola Hawdon. "Ensuring a personalised approach." Advances in Mental Health and Intellectual Disabilities 13, no. 1 (February 15, 2019): 15–24. http://dx.doi.org/10.1108/amhid-03-2018-0010.
Анотація:
Purpose The purpose of this paper is to outline how personal health budgets and a universal, integrated model of support, can positively transform the way in which individuals with a learning disability experience their health and support needs. Design/methodology/approach The review recognises that Integrated Personal Commissioning, as a policy approach, provides the framework to offer personalised care, and enables people to live an independent, happy, healthy and meaningful life. Findings Evidence suggests that a personalised and integrated approach to both health and social care not only offers better outcomes on all levels for the individual, but also benefits the system as a whole. Originality/value The study reveals that a personalised care leads to people to have choices and control over decisions that affect in better health and wellbeing outcomes for people.
2
Costello, Robert. "Supporting Doctoral Students through the Personalisation of a Graduate Virtual Research Environment." International Journal of Adult Vocational Education and Technology 7, no. 4 (October 2016): 54–71. http://dx.doi.org/10.4018/ijavet.2016100104.
Анотація:
This paper offers a case study in which a traditional Learning Management System (LMS) was enhanced through learning theories and web-based technologies to support the development of doctoral students. The model being used here, can address and support a personalised learning approach to assist postgraduate students, as part of matching their skills with a repository of rich media and activities. The mixed method research approach adopted here aided into the investigation into the Graduate Virtual Research Environment (GVRE) while analysing factors like usability, accessibility, goal orientation and evolving the learners' needs. The author argues by tailoring the gap between learning theories and technology with the complexities of human nature one can adapt the educational setting to provide a LMS which can be personalized for doctoral students.
3
Pappas, Ilias O., Panos E. Kourouthanassis, Sofia Papavlasopoulou, and Vassilios Chrissikopoulos. "Emotions in Motion." International Journal of Online Marketing 7, no. 1 (January 2017): 64–78. http://dx.doi.org/10.4018/ijom.2017010104.
Анотація:
This research examines the combined effect of positive and negative emotions on online shopping behaviour when customers use personalised services. Data from 421 customers, experiences with personalised online shopping, were used to empirically validate the effect of the level of emotions of different valence and intensity on their intention to purchase online. The findings suggest that as the intensity of positive emotions increases, shoppers are more willing to purchase from the online store. Nevertheless, this association is statistically significant only in those cases that the sample exhibits low intensity of negative emotions. Moreover, an increase on the intensity of negative emotions tends to reduce shoppers' intentions to purchase. Results show that online vendors should aim to induce positive emotions since they are more important that negative ones. This paper offers a first step in evaluating the multidimensional role of emotions in personalised e-commerce.
4
Scott, Jacob G., Alexander G. Fletcher, Philip K. Maini, Alexander R. A. Anderson, and Philip Gerlee. "A filter-flow perspective of haematogenous metastasis offers a non-genetic paradigm for personalised cancer therapy." European Journal of Cancer 50, no. 17 (November 2014): 3068–75. http://dx.doi.org/10.1016/j.ejca.2014.08.019.
5
Girard, Evans, Rita Yusri, Adel Abusitta, and Esma Aïmeur. "An Automated Stable Personalised Partner Selection for Collaborative Privacy Education." International Journal on Integrating Technology in Education 10, no. 2 (June 30, 2021): 9–22. http://dx.doi.org/10.5121/ijite.2021.10202.
Анотація:
E-learning platforms have never been as in-demand as they are now since the recent pandemic making privacy education more important than ever. However, for the most part, these platforms are single-user learning environments and lack student-student interactions. To overcome this deficiency, we propose a collaborative e-learning platform for privacy education that matches students in a stable and automatic manner according to students’ preferences. Each student is represented by a vector profile that is created from behavioural skills and academic knowledge obtained from the platform. Once the preferences are determined, the residents-hospitals matching algorithm is applied to select students who will collaborate with one another. Experimental results show that the proposed model offers an effective way to create stable, thus satisfied, coalitions of students from two groups of arbitrary sizes. In addition, the automation allows students to skip the tedious process of manually selecting partners. Therefore, saving their time to collaborate on privacy education with their teammates helping them to increase their privacy awareness.
6
Lush, Victoria, Christopher Buckingham, Suzanne Edwards, and Ulysses Bernardet. "Towards Accessible Mental Healthcare through Augmented Reality and Self-Assessment Tools." International Journal of Online and Biomedical Engineering (iJOE) 16, no. 04 (April 8, 2020): 33. http://dx.doi.org/10.3991/ijoe.v16i04.12095.
Анотація:
<p class="0abstractCxSpFirst">Mental health presents a growing public health concern worldwide with mental illnesses affecting people’s quality of life and causing an economic impact on societies. The rapidly increasing demand for mental healthcare is calling for new ways of disseminating mental health knowledge and for supporting people with mental health illnesses. As an alternative to traditional mental health therapies and treatments, mental health self-assessment and self-management tools become widely available to the public. While such tools can potentially offer more timely personalised support, individuals seeking help are faced with the challenge of making an appropriate choice from an exhaustive number of online tools, mobile apps, and support programs.</p><p class="0abstractCxSpLast">In this article, we present myGRaCE – a self-assessment and self-management mental health tool made accessible to users via Augmented Reality technologies. The advantage of the system is that it provides a direct pathway to relevant and reliable mental health resources and offers a positive incentive and interventions for at-risk users. The system offers service users the resources to gain a better understanding of their mental state and increase control of their mental health conditions via self-monitoring and self-help.</p>
7
Samuel, Sophia, and Heather Thompson. "Critical reflection: a general practice support group experience." Australian Journal of Primary Health 24, no. 3 (2018): 204. http://dx.doi.org/10.1071/py17092.
Анотація:
The problem of medical practitioner burnout and loss of morale remains an ongoing challenge in the Australian health workforce. Collegiate recommendations are individualistic or personalised, or worse, punitive. Critical reflection in supervision is a long-accepted and key aspect of social work theory and practice. The use of critical reflection within a general practitioner support group is examined and key learnings from our findings over 3years are discussed. All participants reported the group enhanced individual and team workplace satisfaction, and wellbeing. This Practice and Innovation paper offers an example that could help improve current best practice in the pastoral support of medical practitioners.
8
Aarseth, Helene. "Fear of Falling – Fear of Fading: The Emotional Dynamics of Positional and Personalised Individualism." Sociology 52, no. 5 (October 2, 2017): 1087–102. http://dx.doi.org/10.1177/0038038517730219.
Анотація:
This article explores the emotional dynamics involved in the shaping of middle-class subjectivities, aiming to move beyond the ‘fear of falling’ thesis and the attendant emphasis on the quest for positional advantage. I argue that this thesis offers a one-dimensional notion of what it is that drives middle-class perceptions, values and motivations, unsuitable for explaining current tensions between symbolic and economic fractions. Drawing on a comparative narrative interview study of managerial and professional parents in Norway, I describe the emotionally charged investments – ‘fear of falling’ and ‘fear of fading’ – as well as the excitements that drive different modes of socialisation in these groups. Further developing the phenomenological and psychosocial trajectories in Bourdieu’s practice theory yields a productive tool for exploring these modes of socialisation, contributing to an enhanced conception of emotional dynamics of different middle-class subjectivities.
9
Robertson, Alison. "Claiming Identity, Delineating Category." Journal of the British Association for the Study of Religion (JBASR) 20 (September 21, 2018): 100. http://dx.doi.org/10.18792/jbasr.v20i0.31.
Анотація:
Identity is an important focus for discourse in the contemporary world, used as an indicator of elements that are felt by an individual to be an important part of how they see and understand themselves. Self-identification commonly employs terms that can also be used to signify an analytic category, and the understanding that underlies these different uses is often neither wholly shared nor entirely distinct. Recognition of different use is thus potentially significant in research related to the groups, behaviours or concepts signified by such terms. This paper utilises concepts of religion(ing) and kink - both terms which can be, and are, used as claimed identities and as analytic categories - to reflect upon the porosity of such concepts when they are deployed in individual and academic narratives. Qualitative research into kink (understood as a marker of identity) is used to explore how personalised practices contribute to religioning processes (understood as a category label). This offers opportunities to consider how personalised practices contribute to the religioning processes of world- and/or meaning- and/or story-making, and also demonstrates the porosity of concepts like kink and non-kink, religious and non-religious, as they are constructed, maintained and/or disrupted within individual and academic narratives.
10
Cooke, Lesley Anne, Bwalya Lungu, and Lavern Samuels. "Virtual Engagement: A Nexus Between Internationalisation and Decolonisation of the Curriculum in the PEESA III Project?" Balkan Region Conference on Engineering and Business Education 1, no. 1 (October 1, 2019): 35–43. http://dx.doi.org/10.2478/cplbu-2020-0005.
Анотація:
AbstractInternationalisation and decolonisation are both prominent issues currently being discussed in South African Higher Education institutions. There is a strong impetus for decolonisation of curriculum design, development and delivery. Experience with the implementation of Collaborative Online International Learning at Durban University of Technology (DUT) has demonstrated that this approach to has immense potential for transformation of learning and teaching. The broader concepts of e-internationalisation and Virtual Engagement allow for even greater flexibility in fostering international collaboration, and opportunities for decolonisation of the curriculum. This paper briefly discusses internationalisation and decolonisation in general and at DUT specifically, and explores the opportunities that VE offers to address these imperatives in the implementation of the Personalised Engineering Education (PEESA) III Project.
11
Bachmair, Ben. "Communicative Modes after the Coherent Media – Orientation within as semiotic space." MedienPädagogik: Zeitschrift für Theorie und Praxis der Medienbildung 2006, Occasional Papers (May 10, 2006): 1–29. http://dx.doi.org/10.21240/mpaed/00/2006.05.10.x.
Анотація:
Mass communication as our familiar mode of a medial organised public is integrated into the current cultural change of society. The article takes a look at one aspect of this change, which comes along with a shift in the function of the recipient with regard to medial texts. Reception takes over essential functions of text production, which until then has been left to the authors and broadcasters. While the distinct, coherent medium is no longer shaping our mass communication as token for granted, new text types like intramedial links gain importance. They give the recipient the possibility to combine media offers into a kind of personalised units, which fit in the recipients' relevance structures.
12
Fakih, David F. "Advancing the Management of Non-small Cell Lung Cancer." European Oncology & Haematology 13, no. 01 (2017): 53. http://dx.doi.org/10.17925/eoh.2017.13.01.53.
Анотація:
Advances in the development of targeted therapies and immunotherapy have transformed the management of non small-cell lung cancer (NSCLC). Targeting angiogenesis and molecular drivers of carcinogenesis has led to the approval of several new therapies. More recently, immunotherapeutic approaches have been investigated in the treatment setting of NSCLC. These include immune checkpoint inhibitors (e.g. anti-cytotoxic T-lymphocyte antigen-4 [CTLA-4], anti-programmed death-1 (PD-1) and anti-programmed death-ligand 1 [PD-L1] agents). The emergence of so many therapeutic options offers the potential for personalised therapy. Molecular profiling can inform treatment decisions but there is a need for more data to determine the optimal sequencing and combination of targeted and immunotherapeutic agents.
13
Falter, Maarten, Martijn Scherrenberg, and Paul Dendale. "Digital Health in Cardiac Rehabilitation and Secondary Prevention: A Search for the Ideal Tool." Sensors 21, no. 1 (December 22, 2020): 12. http://dx.doi.org/10.3390/s21010012.
Анотація:
Digital health is becoming more integrated in daily medical practice. In cardiology, patient care is already moving from the hospital to the patients’ homes, with large trials showing positive results in the field of telemonitoring via cardiac implantable electronic devices (CIEDs), monitoring of pulmonary artery pressure via implantable devices, telemonitoring via home-based non-invasive sensors, and screening for atrial fibrillation via smartphone and smartwatch technology. Cardiac rehabilitation and secondary prevention are modalities that could greatly benefit from digital health integration, as current compliance and cardiac rehabilitation participation rates are low and optimisation is urgently required. This viewpoint offers a perspective on current use of digital health technologies in cardiac rehabilitation, heart failure and secondary prevention. Important barriers which need to be addressed for implementation in medical practice are discussed. To conclude, a future ideal digital tool and integrated healthcare system are envisioned. To overcome personal, technological, and legal barriers, technological development should happen in dialog with patients and caregivers. Aided by digital technology, a future could be realised in which we are able to offer high-quality, affordable, personalised healthcare in a patient-centred way.
14
Costello, Robert. "Supporting the Needs of Higher Educational Learners, through the ‘Postgraduate Pathways'." International Journal of Organizational and Collective Intelligence 5, no. 3 (July 2015): 16–31. http://dx.doi.org/10.4018/ijoci.2015070102.
Анотація:
This paper offers a case study in Adaptive Personalised Learning for Postgraduates within Higher Education: What is already known about this topic: Current State of Higher Education within supporting postgraduate careers and transferable skills Raised standards and improvements within universities expectations required by the QAA Research students and their academic and employability needs. What this paper adds: A postgraduate Recommender Systems for educational pathway to aid with on-line support towards selecting suitable transferable skills depending on departments. Engagement of postgraduate research students and their perception on transferable skills through additional training in Higher Education. Implications for practice: Development of an online postgraduate recommender system, that can guide students on individual modules, courses or programmes to take to benefit them while carrying out there PhD research. Capture a current snap shot of the current trends that the University is facing.
15
Jarockyte, Greta, Vitalijus Karabanovas, Ricardas Rotomskis, and Ali Mobasheri. "Multiplexed Nanobiosensors: Current Trends in Early Diagnostics." Sensors 20, no. 23 (December 2, 2020): 6890. http://dx.doi.org/10.3390/s20236890.
Анотація:
The ever-growing demand for fast, cheap, and reliable diagnostic tools for personalised medicine is encouraging scientists to improve existing technology platforms and to create new methods for the detection and quantification of biomarkers of clinical significance. Simultaneous detection of multiple analytes allows more accurate assessment of changes in biomarker expression and offers the possibility of disease diagnosis at the earliest stages. The concept of multiplexing, where multiple analytes can be detected in a single sample, can be tackled using several types of nanomaterial-based biosensors. Quantum dots are widely used photoluminescent nanoparticles and represent one of the most frequent choices for different multiplex systems. However, nanoparticles that incorporate gold, silver, and rare earth metals with their unique optical properties are an emerging perspective in the multiplexing field. In this review, we summarise progress in various nanoparticle applications for multiplexed biomarkers.
16
Szpechciński, Adam, and Mateusz Florczuk. "The role of microRNA in the molecular mechanisms of resistance to EGFR tyrosine kinase inhibitor treatment in NSCLC and the current perspective on its clinical applications." Postępy Polskiej Medycyny i Farmacji 5 (June 26, 2017): 45–58. http://dx.doi.org/10.5604/01.3001.0011.6194.
Анотація:
Non-small cell lung cancer (NSCLC) is the leading cause of death from cancer over the world. Currently, a large number of research studies are conducted to develop and implement new treatment strategies. Intensive efforts are also made to improve robustness of modern molecular diagnostics to identify more precisely specific genetic and epigenetic cancer features (predictive biomarkers) and adjust the most effective treatment options for individual patient (personalized therapy). So called targeted therapy based on using epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) is nowadays the most widely chosen form of personalized treatment in advanced NSCLC. Favorable response to treatment with EGFR TKIs depends on the presence of somatic mutations in EGFR gene, detectable in lung cancer tissue. The resistance to EGFR TKIs acquired by most patients during treatment is the main ob-stacle to overcome in NSCLC targeted therapy. miRNAs (microRNAs) are small, noncoding RNA molecules that play a keyrole in the regulation of basic cellular processes, includingdif-ferentiation, proliferation and apoptosis, by controllinggene expression at the posttranscriptional level.Deregulation of miRNA activity results in the loss of homeostasisand the development of a number of pathologies, includinglung cancer. During lung carcinogenesis, miRNAs exhibitdual regulatory function: they act as oncogenes or as tumour suppressors. Better understanding of epigenetic mechanisms re-gulating either the sensitivity or the resistance of NSCLC cells to EGFR TKIs, through activity of miRNAs, may become a breakthrough in targe-ted therapy of lung cancer. The dual regulatory role of miRNA in cancer might drive the further development of personalised therapies in NSCLC. Furthermore, stable forms of tumourrelated miRNAs are detectable in the peripheral blood of patients with NSCLC that offers the potential benefits of using extracellular miRNAs as part of the diagnostic evaluation of cancer.
17
Perkins, Rachel, Julie Atkins, Nicole Hunter, Poppy Repper, Peter David Robertson, Phoebe Thornton, and Sue Thornton. "Real lives: promoting recovery through personalisation and peer support." Mental Health and Social Inclusion 19, no. 1 (March 9, 2015): 22–29. http://dx.doi.org/10.1108/mhsi-11-2014-0037.
Анотація:
Purpose – The purpose of this paper is to describe the development of Real Lives: a community interest company that provides peer support for people who face significant mental health challenges using personal budgets. Design/methodology/approach – The paper offers a descriptive summary of the vision behind Real Lives and the successful realisation of this vision in practice based on interviews by the first author with the directors, Operational Manager, Cafe Manager and “Peers and Allies for in Living” who provide support to clients. Findings – The successful development of Real Lives shows that it is possible to utilise peer support and personal budgets to a create small, values based, financially viable organisation outside the statutory sector that is part of its community and can provide outside the statutory sector. A service for people facing significant mental health challenges that is personalised, recovery-focused and puts the client in control and is focused on helping them to do the things they want to do and pursue their aspirations. Originality/value – Real Lives is an innovative recovery-focused service that is part of its community and offers a model for utilising Self-Directed Support and personal budgets and that might be replicated by others.
18
Browning, Michael, Amy C. Bilderbeck, Rebecca Dias, Colin T. Dourish, Jonathan Kingslake, Jürgen Deckert, Guy M. Goodwin, et al. "The clinical effectiveness of using a predictive algorithm to guide antidepressant treatment in primary care (PReDicT): an open-label, randomised controlled trial." Neuropsychopharmacology 46, no. 7 (February 26, 2021): 1307–14. http://dx.doi.org/10.1038/s41386-021-00981-z.
Анотація:
AbstractDepressed patients often do not respond to the first antidepressant prescribed, resulting in sequential trials of different medications. Personalised medicine offers a means of reducing this delay; however, the clinical effectiveness of personalised approaches to antidepressant treatment has not previously been tested. We assessed the clinical effectiveness of using a predictive algorithm, based on behavioural tests of affective cognition and subjective symptoms, to guide antidepressant treatment. We conducted a multicentre, open-label, randomised controlled trial in 913 medication-free depressed patients. Patients were randomly assigned to have their antidepressant treatment guided by a predictive algorithm or treatment as usual (TaU). The primary outcome was the response of depression symptoms, defined as a 50% or greater reduction in baseline score of the QIDS-SR-16 scale, at week 8. Additional prespecified outcomes included symptoms of anxiety at week 8, and symptoms of depression and functional outcome at weeks 8, 24 and 48. The response rate of depressive symptoms at week 8 in the PReDicT (55.9%) and TaU (51.8%) arms did not differ significantly (odds ratio: 1.18 (95% CI: 0.89–1.56), P = 0.25). However, there was a significantly greater reduction of anxiety in week 8 and a greater improvement in functional outcome at week 24 in the PReDicT arm. Use of the PReDicT test did not increase the rate of response to antidepressant treatment estimated by depressive symptoms but did improve symptoms of anxiety at week 8 and functional outcome at week 24. Our findings indicate that personalisation of antidepressant treatment may improve outcomes in depressed patients.
19
Tan, Melissa, Gerhardt Attard, and Robert Huddart. "Circulating Tumour DNA in Muscle-Invasive Bladder Cancer." International Journal of Molecular Sciences 19, no. 9 (August 29, 2018): 2568. http://dx.doi.org/10.3390/ijms19092568.
Анотація:
Circulating tumour DNA (ctDNA) is an attractive tool in cancer research, offering many advantages over tissue samples obtained using traditional biopsy methods. There has been increasing interest in its application to muscle-invasive bladder cancer (MIBC), which is recognised to be a heterogeneous disease with overall poor prognosis. Using a range of platforms, studies have shown that ctDNA is detectable in MIBC and may be a useful biomarker in monitoring disease status and guiding treatment decisions in MIBC patients. Currently, with no such predictive or prognostic biomarkers in clinical practice to guide treatment strategy, there is a real unmet need for a personalised medicine approach in MIBC, and ctDNA offers an exciting avenue through which to pursue this goal. In this article, we present an overview of work to date on ctDNA in MIBC, and discuss the inherent challenges present as well as the potential future clinical applications.
20
J, Paul Rajasingh, Sharmishtha Sen*, and Shreyes Prasad. "User Reputation Calculation for Service-Oriented Environments." Regular issue 10, no. 7 (May 30, 2021): 107–9. http://dx.doi.org/10.35940/ijitee.g8953.0510721.
Анотація:
All the cloud based applications work on serviceoriented architectures and collaborate with multiple components from other services to execute discreet application logic. In this environment there are a lot of Web services facilitated to the customer to make the systems. As the potential of the same Web service will change with respect to users' needs. On an average a user will be heavily relied on tools to aid their activities on the internet vice versa the Service provider are also dependent on the users profile and what services are being used in the system. A User Reputation model offers a solution to the Service providers in supporting their service decision based on the User Profile. This model takes usage ratings as data and produces a personalised score. We suggest a new Cumulative separation on the basis of Tags and popularity estimation method and showcase its enhanced filtration ability.
21
Dreyer, Stephan, Nigel Jamieson, Lisa Evers, Marc Jones, Sancha Martin, Fraser Duthie, Liz Musgrove, et al. "Feasibility and clinical utility of EUS guided biopsy of pancreatic cancer for next-generation genomic sequencing." Journal of Clinical Oncology 36, no. 4_suppl (February 1, 2018): 296. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.296.
Анотація:
296 Background: Next-generation sequencing technology has made genomic profiling guided therapy a reality for many cancer types. The aim of this study is to investigate the feasibility of genomic profiling using standard clinical endoscopic ultrasound (EUS) core biopsy samples of Pancreatic Cancer (PC) to allow personalised cancer care. Methods: 78 patients underwent additional research biopsy at the time of diagnostic EUS biopsy. En-face frozen section was performed to enable targeted macro-dissection prior to DNA extraction, quantification and targeted gene sequencing (Agilent Comprehensive Cancer Gene Panel). Matching formalin-fixed (FFPE) diagnostic EUS biopsies and fresh frozen surgical resection specimens also underwent genomic profiling for comparison. Whole genome (WGS) and RNA sequencing was performed in selected patients. Results: Targeted panel sequencing ( n = 61) revealed known PC genes ( KRAS, GNAS, TP53, CDKN2A, SMAD4) in 36 patients with histological evidence of PC. Potentially actionable somatic mutations (BRCA1, BRCA2, ATM, BRAF, JAK3) were found in 6 (17%) patients. WGS ( n = 5) of EUS samples confirmed mutations identified on panel sequencing and revealed relevant mutational signatures and structural variation patterns that can act as putative biomarkers of therapeutic responsiveness. RNA sequencing ( n = 54) segregated patients into key clinically relevant molecular PC subtypes based on transcriptome and reveals novel molecular insights into advanced, unresectable PC ( n = 38). Conclusions: We demonstrate here novel multi-omic analysis of pancreatic cancer using standard clinical EUS guided fine needle biopsies. Multi-omic analysis of EUS biopsies offers potential clinical utility to guide personalized therapy of PC in both the neoadjuvant and advanced settings.
22
Masson, Golnessa, Katie Mills, Simon J. Griffin, Stephen J. Sharp, William MP Klein, Stephen Sutton, and Juliet A. Usher-Smith. "A randomised controlled trial of the effect of providing online risk information and lifestyle advice for the most common preventable cancers." British Journal of General Practice 69, suppl 1 (June 2019): bjgp19X702893. http://dx.doi.org/10.3399/bjgp19x702893.
Анотація:
BackgroundPrevention offers an effective public health strategy for cancer control. One approach that could be incorporated within general practice is the provision of personalised risk information. Few trial data are available concerning the impact of cancer risk information on behaviour.AimTo assess the short-term effects on computed cancer risk and self-reported health-related behaviours of providing personalised cancer risk information.MethodA total of 1018 participants, recruited through the online platform Prolific, were randomised to either a control group receiving cancer-specific lifestyle advice alone or one of three intervention groups receiving the same lifestyle advice alongside their estimated 10-year risk of developing one of the five most common preventable cancers. Cancer risk was calculated from self-reported behavioural risk factors and presented in one of three formats: bar-chart, pictograph, or qualitative scale. The primary outcome was change from baseline in computed risk relative to an individual with a recommended lifestyle (RRI) at 3 months. Secondary outcomes included: self-reported health-related behaviours, accuracy of risk perception, risk conviction, anxiety, worry, intention to change behaviour, self-efficacy, and response-efficacy.ResultsAt immediate follow-up, accuracy of risk perception (P<0.001), risk conviction (P <0.001), and response-efficacy (P = 0.04) increased in all intervention groups. After 3 months there were no between-group differences in change in RRI (P = 0.68) or any of the secondary outcomes.ConclusionThis study has shown that a risk communication intervention can increase short-term risk accuracy and response efficacy and for the first time that risk conviction can be manipulated through risk communication. However, these effects were not sustained over time or associated with behaviour change.
23
De Jong, Sara, and Ilker Ataç. "Demand and Deliver: Refugee Support Organisations in Austria." Social Inclusion 5, no. 3 (September 19, 2017): 28–37. http://dx.doi.org/10.17645/si.v5i3.1003.
Анотація:
This article analyses four emerging refugee support organisations in Austria, founded before the so-called refugee crisis in 2015. It argues that these organisations have managed to occupy a middle space between mainstream NGOs and social movements with structures of inclusive governance, a high degree of autonomy, personalised relationships with refugees, and radical critique combined with service delivery. Based on interviews with the founders of each organisation, we show that their previous NGO and social movement experience formed a springboard for the new initiatives. It not only allowed them to identify significant gaps in existing service provision, but also provided the space of confrontation with the asylum system inspiring a strong sense of outrage, which in turn developed into political critique. We argue that this critique combined with identifying the needs of asylum seekers and refugees has produced a new type of organisation, which both delivers services and articulates radical demands. Each organisation offers a space of encounter, which undoes the ‘organised disintegration’ of the asylum system.
24
Scott, Jan, Marion Leboyer, Ian Hickie, Michael Berk, Flavio Kapczinski, Ellen Frank, David Kupfer, and Patrick McGorry. "Clinical staging in psychiatry: a cross-cutting model of diagnosis with heuristic and practical value." British Journal of Psychiatry 202, no. 4 (April 2013): 243–45. http://dx.doi.org/10.1192/bjp.bp.112.110858.
Анотація:
SummaryStaging models are used routinely in general medicine for potentially serious or chronic physical disorders such as diabetes, arthritis and cancers, describing the links between biomarkers, clinical phenotypes and disease extension, and promoting a personalised or stratified medicine approach to treatment planning. Clinical staging involves a detailed description of where an individual exists on a continuum of disorder progression from stage 0 (an at-risk or latency stage) through to stage IV (late or end-stage disease). The approach is popular owing to its clinical utility and is increasingly being applied in psychiatry. The concept offers an informed approach to research and the active promotion of indicated prevention and early intervention strategies. We suggest that for young persons with emerging bipolar disorder, such transdiagnostic staging models could provide a framework that better reflects the developmental psychopathology and matches the complex longitudinal inter-relationships between subsyndromal and syndromal mood, psychotic and other disorders.
25
Huber, Rudolf M., Dirk De Ruysscher, Hans Hoffmann, Simone Reu, and Amanda Tufman. "Interdisciplinary multimodality management of stage III nonsmall cell lung cancer." European Respiratory Review 28, no. 152 (June 30, 2019): 190024. http://dx.doi.org/10.1183/16000617.0024-2019.
Анотація:
Stage III nonsmall cell lung cancer (NSCLC) comprises about one-third of NSCLC patients and is very heterogeneous with varying and mostly poor prognosis. It is also called “locoregionally or locally advanced disease”. Due to its heterogeneity a general schematic management approach is not appropriate. Usually a combination of local therapy (surgery or radiotherapy, depending on functional, technical and oncological operability) with systemic platinum-based doublet chemotherapy and, recently, followed by immune therapy is used. A more aggressive approach of triple agent chemotherapy or two local therapies (surgery and radiotherapy, except for specific indications) has no benefit for overall survival. Until now tumour stage and the general condition of the patient are the most relevant prognostic factors. Characterising the tumour molecularly and immunologically may lead to a more personalised and effective approach. At the moment, after an exact staging and functional evaluation, an interdisciplinary discussion amongst the tumour board is warranted and offers the best management strategy.
26
Dean, Harry F., Fiona Carter, and Nader K. Francis. "Modern perioperative medicine – past, present, and future." Innovative Surgical Sciences 4, no. 4 (December 18, 2019): 123–31. http://dx.doi.org/10.1515/iss-2019-0014.
Анотація:
AbstractModern perioperative medicine has dramatically altered the care for patients undergoing major surgery. Anaesthetic and surgical practice has been directed at mitigating the surgical stress response and reducing physiological insult. The development of standardised enhanced recovery programmes combined with minimally invasive surgical techniques has lead to reduction in length of stay, morbidity, costs, and improved outcomes. The enhanced recovery after surgery (ERAS) society and its national chapters provide a means for sharing best practice in this field and developing evidence based guidelines. Research has highlighted persisting challenges with compliance as well as ensuring the effectiveness and sustainability of ERAS. There is also a growing need for increasingly personalised care programmes as well as complex geriatric assessment of frailer patients. Continuous collection of outcome and process data combined with machine learning, offers a potentially powerful solution to delivering bespoke care pathways and optimising individual management. Long-term data from ERAS programmes remain scarce and further evaluation of functional recovery and quality of life is required.
27
Selli, Cigdem, and Andrew H. Sims. "Neoadjuvant Therapy for Breast Cancer as a Model for Translational Research." Breast Cancer: Basic and Clinical Research 13 (January 2019): 117822341982907. http://dx.doi.org/10.1177/1178223419829072.
Анотація:
Neoadjuvant therapy, where patients receive systemic therapy before surgical removal of the tumour, can downstage tumours allowing breast-conserving surgery, rather than mastectomy. In addition to its impact on surgery, the neoadjuvant setting offers a valuable opportunity to monitor individual tumour response. The effectiveness of standard and/or potential new therapies can be tested in the neoadjuvant pre-surgical setting. It can potentially help to identify markers differentiating patients that will potentially benefit from continuing with the same or a different adjuvant treatment enabling personalised treatment. Characterising the molecular response to treatment over time can more accurately identify the significant differences between baseline samples that would not be identified without post-treatment samples. In this review, we discuss the potential and challenges of using the neoadjuvant setting in translational breast cancer research, considering the implications for improving our understanding of response to treatment, predicting therapy benefit, modelling breast cancer dormancy, and the development of drug resistance.
28
Gozzi, Maurizio, and Paola Macchi. "Salute mentale, inserimento lavorativo e cooperazione sociale: l'esperienza di Reggio Emilia." RIVISTA SPERIMENTALE DI FRENIATRIA, no. 2 (August 2009): 89–104. http://dx.doi.org/10.3280/rsf2009-002005.
Анотація:
- social co-operatives in Reggio Emilia, focalizing on the quality of relationships, have developed work inclusion activities and methods for people suffering of mental distress. The different experiences of the various co-operatives have one common aim: meet each person's needs to support work inclusion and defend the person's dignity. Each co-operative offers however different services that combine diverse learning and working contexts with personal abilities and autonomy. These developments have led co-operatives and local authorities to co-design work inclusion programmes and tutoring tools, and to co-manage their development, evaluation and revision. Guidelines for work inclusion of people with mental distress were printed and provincial work inclusion agencies were created. These local experiences should be studied to keep them focused on the changing needs of the population.Key words: social cooperation, relational goods, psychosocial rehabilitation, advocacy, provincial agencies for work inclusion, personalised projects.Parole chiave: cooperazione sociale, beni relazionali, percorsi socio-terapeutici riabilitativi, advocacy, nuclei territoriali, riabilitazione, progettazione individuale.
29
McCray, Janet, and Adam Palmer. "Commissioning personalised care in the English adult social care sector: an action research model to support leadership development." Social Care and Neurodisability 5, no. 1 (February 4, 2014): 3–15. http://dx.doi.org/10.1108/scn-05-2013-0021.
Анотація:
Purpose – The purpose of this paper is to present the perspectives of English adult social care sector partners on the qualifications and standards required for leaders as they prepare to meet the demands of commissioning personalised care. Continuing an action research cycle guided by Coghlan and Brannicks (2010, p. 4) organisational centred model (McCray and Palmer, 2009) it benefits from the previous experience and reflection in action of the partners and researchers. Set in a general social care context, lessons learned from the study outcomes will be of interest to both commissioners of services and service users with acquired brain injury. Design/methodology/approach – A model of action research informed by Coghlan and Brannicks’ (2010, p. 4) organisational centred model focused on context, quality of relationships, quality of the research process and its’ outcomes was used. The role of the authors was to facilitate diagnosis of the leadership issues arising from the implementation of personalised care in the English adult social care sector and in collaboration with sector partners seek resolutions. Six focus groups comprising two commissioners, service providers, user group and care manager/social work leads were facilitated at two separate events in the south of England. Findings – Findings presented are derived from focus group discussions with strategic and organisational leaders and service user partners from the English adult social care sectors. Analysis of focus group data identified a number of themes. The overarching themes of human resource management, gaps in industry standards and leadership are discussed here. Whilst industry sector standard qualifications and frameworks may be at the centre of strategic planning for transformation, findings here have identified that additional support will be required to create leaders who can commission successfully to create cultural change. New approaches to leadership development may be needed to facilitate this process. Research limitations/implications – The study offers a single method qualitative research approach based on two local authorities in the south of England. It presents a localised and particular view of leadership development needs. Practical implications – The paper shows how action research can make a contribution to knowledge and practice. Originality/value – The paper provides interesting new insights into the skills for commissioning in a changing public and third sector environment with reference to commissioning personalised support for people with brain injury.
30
Davies, Sarah R. "University communications as auto-communication: the NTNU ‘Challenge Everything’ campaign." Journal of Communication Management 24, no. 3 (March 19, 2020): 227–43. http://dx.doi.org/10.1108/jcom-08-2019-0120.
Анотація:
PurposeThis article offers an in-depth exploration of university communications practice by describing and analysing a publicity and recruitment campaign, called ‘Challenge Everything’, carried out by the Norwegian University of Science and Technology (NTNU) in 2018. By providing insight into internal sense-making around the campaign it contributes to literatures in science communication and communication management.Design/methodology/approachThis qualitative research uses semi-structured interviews and informal organisational ethnography, mobilising concepts of sense-making and auto-communication to guide analysis. The focus is on how organisation members made sense of the Challenge Everything campaign.FindingsThe analysis focuses on four key themes within organisational sense-making about the campaign: the openness of the campaign meant that it was readily picked up on and personalised by university staff; its meaning was always contextual, shaped by organisation members' roles, interests, and concerns; its controversy seems to primarily derive from questions of representation, and specifically whether organisation members recognised within it their own experiences of university culture; and its development points to the rise of new forms of expertise within university organisation, and the contestation of these.Research limitations/implicationsThe research offers only a partial snapshot of one instance of university communications. However, in demonstrating how public campaigns also operate as auto-communication it has important implications for strategic communication within complex organisations such as universities.Originality/valueThe research has particular value in offering an in-depth qualitative study of university marketing practices and the effects these have within an organisation.
31
Cochrane, Robyn, and Tui McKeown. "Vulnerability and agency work: from the workers’ perspectives." International Journal of Manpower 36, no. 6 (September 7, 2015): 947–65. http://dx.doi.org/10.1108/ijm-01-2014-0030.
Анотація:
Purpose – The notion of worker vulnerability is often seen as synonymous with disadvantage in discussions of nonstandard work. The purpose of this paper is to separate and examine these two notions by considering economic, social and psychological perspectives and exploring the reality as experienced by agency workers. Design/methodology/approach – In total, 178 Australian clerical agency workers employed by eight agencies completed a mail questionnaire. Personalised responses were subjected to computer-assisted template analysis. Findings – Sample characteristics revealed a gendered and heterogeneous workforce. Findings showed evidence of economic, psychological and social vulnerabilities although favourable features were also reported. This apparent contradiction suggests linkages between the features of nonstandard work, worker preferences, individual characteristics and the experience of worker vulnerability. Research limitations/implications – The notion of varying degrees of worker vulnerability offers a new lens to investigate agency work. The relatively small sample size, focus on clerical work and features of the Australian context may limit generalisability. Practical implications – Findings demonstrate the nature and extent of agency worker vulnerability which allows us to offer policy interventions for governments, agencies and user organisations and insights for prospective agency workers. Originality/value – The widespread use of agency workers provides an imperative for frameworks to assess the nuances of the agency work experience. This study presents the reality of agency work as experienced by the workers and reveals the good and bad aspects of agency work.
32
Ballard, James, and Philip Ian Butler. "Learner enhanced technology." Journal of Applied Research in Higher Education 8, no. 1 (February 1, 2016): 18–43. http://dx.doi.org/10.1108/jarhe-09-2014-0074.
Анотація:
Purpose – The purpose of this paper is to propose a conceptual model of engagement, appropriated from social media marketing, as a sense-making framework to understand engagement as a measurable process through the development of engagement profiles. To explore its potential application to education the paper follows previous work with Personalised Learning strategies to place emphasis on the promotion of the learner voice – their ability to influence decisions affecting them and their community. Design/methodology/approach – This paper will position engagement as a sociocultural process and adopt an Activity Theory based methodology demonstrated through a desk analysis of VLE data from a further education college. Findings – The analysis suggests that the approach can yield insights that may be elusive in traditional measures reinforcing the overall conceptual proposal for a multi-method approach to profiling learner engagement. Research limitations/implications – The paper has focused on presentation and exploration of the conceptual approach, which has limited the scope to broaden the discussion of the desk analysis and wider findings that this approach reveals. Practical implications – It is intended that the approach offers a generalizable model that can be adopted by institutions planning to measure engagement or develop learner activity profiles. Several areas of immediate potential are identified throughout the paper. Originality/value – This paper contributes a multi-method approach to engagement as argued for in recent engagement literature. This should offer institutions a way to realise value from emerging ideas within related domains of Learning Design and Learning Analytics.
33
Curti, Carlo, Daniel J. Kirby, and Craig A. Russell. "Stereolithography Apparatus Evolution: Enhancing Throughput and Efficiency of Pharmaceutical Formulation Development." Pharmaceutics 13, no. 5 (April 25, 2021): 616. http://dx.doi.org/10.3390/pharmaceutics13050616.
Анотація:
Pharmaceutical applications of 3D printing technologies are growing rapidly. Among these, vat photopolymerisation (VP) techniques, including Stereolithography (SLA) hold much promise for their potential to deliver personalised medicines on-demand. SLA 3D printing offers advantageous features for pharmaceutical production, such as operating at room temperature and offering an unrivaled printing resolution. However, since conventional SLA apparatus are designed to operate with large volumes of a single photopolymer resin, significant throughput limitations remain. This, coupled with the limited choice of biocompatible polymers and photoinitiators available, hold back the pharmaceutical development using such technologies. Hence, the aim of this work was to develop a novel SLA apparatus specifically designed to allow rapid and efficient screening of pharmaceutical photopolymer formulations. A commercially available SLA apparatus was modified by designing and fabricating a novel resin tank and build platform able to 3D print up to 12 different formulations at a single time, reducing the amount of sample resin required by 20-fold. The novel SLA apparatus was subsequently used to conduct a high throughput screening of 156 placebo photopolymer formulations. The efficiency of the equipment and formulation printability outcomes were evaluated. Improved time and cost efficiency by 91.66% and 94.99%, respectively, has been confirmed using the modified SLA apparatus to deliver high quality, highly printable outputs, thus evidencing that such modifications offer a robust and reliable tool to optimize the throughput and efficiency of vat photopolymerisation techniques in formulation development processes, which can, in turn, support future clinical applications.
34
Bayer, Richard C. "Christian Personalism and Democratic Capitalism." Horizons 21, no. 2 (1994): 313–31. http://dx.doi.org/10.1017/s036096690002853x.
Анотація:
AbstractIn his recent works Michael Novak offers an affirmation of “democratic capitalism” based on a Christian personalist perspective. Novak's scholarship has received increasing attention since the collapse of communism in Eastern Europe, and particularly since the recent encyclical Centesimus Annus. In that encyclical John Paul II offered a qualified affirmation of market economies. This article addresses an important question: to what extent can a Christian personalist social theory be used to offer an affirmation of a market economy, and how might it offer vision and constructive critique? I initiate a creative dialogue between the personalism of Emmanuel Mounier and Michael Novak's presentation of democratic capitalism. I argue that Novak has shed important light on the positive moral aspects of a market system, but I identify and emphasize the important remaining areas for moral concern.
35
Eatough, Virginia, and Karen Shaw. "“It’s like having an evil twin”: an interpretative phenomenological analysis of the lifeworld of a person with Parkinson’s disease." Journal of Research in Nursing 24, no. 1-2 (March 2019): 49–58. http://dx.doi.org/10.1177/1744987118821396.
Анотація:
Background This paper offers an understanding of the lifeworld of a person with Parkinson’s Disease derived from interpretative phenomenological analysis (IPA). Aims The paper has two main aims: firstly, to demonstrate how a focus on individual experience chimes with and can inform current ideas of a more personalised humanised form of healthcare for people living with Parkinson’s disease; and secondly, to demonstrate how an IPA study can illuminate particularity whilst being able to make, albeit cautiously, more general knowledge claims that can inform wider caring practices. Methods It achieves these aims through the detailed description and interpretation of one person’s experience of living with Parkinson's disease using the IPA approach. Results Three analytic themes point to how the various constituents of the lifeworld, such as embodiment, selfhood, temporality and relationality are made manifest. These enable the IPA researcher to make well-judged inferences, which can have value beyond the individual case. Conclusions A key feature of IPA is its commitment to an idiographic approach that recognises the value of understanding a situated experience from the perspective of a particular person or persons.
36
Roberts, Jonathan, and Anna Middleton. "Genetics in the 21st Century: Implications for patients, consumers and citizens." F1000Research 6 (November 17, 2017): 2020. http://dx.doi.org/10.12688/f1000research.12850.1.
Анотація:
The first human genome project, completed in 2003, uncovered the genetic building blocks of humankind. Painstakingly cataloguing the basic constituents of our DNA (‘genome sequencing’) took ten years, over three billion dollars and was a multinational collaboration. Since then, our ability to sequence genomes has been finessed so much that by 2017 it is possible to explore the 20,000 or so human genes for under £1000, in a matter of days. Such testing offers clues to our past, present and future health, as well as information about how we respond to medications so that truly ‘personalised medicine’ is now a reality. The impact of such a ‘genomic era’ is likely to have some level of impact on all of us, even if we are not directly using healthcare services ourselves. We explore how advancements in genetics are likely to be experienced by people, as patients, consumers and citizens; and urge policy makers to take stock of the pervasive nature of the technology as well as the human response to it.
37
Roberts, Jonathan, and Anna Middleton. "Genetics in the 21st Century: Implications for patients, consumers and citizens." F1000Research 6 (January 24, 2018): 2020. http://dx.doi.org/10.12688/f1000research.12850.2.
Анотація:
The first human genome project, completed in 2003, uncovered the genetic building blocks of humankind. Painstakingly cataloguing the basic constituents of our DNA (‘genome sequencing’) took ten years, over three billion dollars and was a multinational collaboration. Since then, our ability to sequence genomes has been finessed so much that by 2018 it is possible to explore the 20,000 or so human genes for under £1000, in a matter of days. Such testing offers clues to our past, present and future health, as well as information about how we respond to medications so that truly ‘personalised medicine’ is now moving closer to a reality.The impact of such a ‘genomic era’ is likely to have some level of impact on an increasingly large number of us, even if we are not directly using healthcare services ourselves. We explore how advancements in genetics are likely to be experienced by people, as patients, consumers and citizens; and urge policy makers to take stock of the pervasive nature of the technology as well as the human response to it.
38
Suman, Amit Kumar. "The Quest for Education: An Insight into the Educational Theories and Practices of the Colonial Government in Bengal Presidency." Indian Historical Review 45, no. 2 (December 2018): 173–88. http://dx.doi.org/10.1177/0376983618804366.
Анотація:
The present article would try to examine the trajectories of an evolving knowledge system or how it travelled from the West and grafted itself on indigenous institutions reconstituting the one already in existence. Western knowledge arrived in India through the coercive agency of colonialism, the colonial administrators, particularly Macaulay, asserting that this knowledge was true and that the indigenous knowledge system, like the gods of the natives, was false. Knowledge was thus sought to be reconstituted rather than being a product of knowing subject from the outside. Thus, the article offers a preliminary analysis of how colonial authority was established over cultural spaces in India first by establishing indigenous centres of higher learning and then by subverting them by bringing the management under colonial authority based on the ideological undercurrent of the superiority of European civilisation and administrative needs. Hence, there were attempts to replace personalised Indian cultural authority by institutionalising and co-opting Indian forms of authority leading to immense changes in the social matrix of the Indian society and culture.
39
Rincon, Jaime A., Angelo Costa, Paulo Novais, Vicente Julian, and Carlos Carrascosa. "ME3CA: A Cognitive Assistant for Physical Exercises that Monitors Emotions and the Environment." Sensors 20, no. 3 (February 5, 2020): 852. http://dx.doi.org/10.3390/s20030852.
Анотація:
Recent studies show that the elderly population has increased considerably in European society in recent years. This fact has led the European Union and many countries to propose new policies for caring services directed to this group. The current trend is to promote the care of the elderly in their own homes, thus avoiding inverting resources on residences. With this in mind, there are now new solutions in this direction, which try to make use of the continuous advances in computer science. This paper tries to advance in this area by proposing the use of a personal assistant to help older people at home while carrying out their daily activities. The proposed personal assistant is called ME3CA, and can be described as a cognitive assistant that offers users a personalised exercise plan for their rehabilitation. The system consists of a sensorisation platform along with decision-making algorithms paired with emotion detection models. ME3CA detects the users’ emotions, which are used in the decision-making process allowing for more precise suggestions and an accurate (and unbiased) knowledge about the users’ opinion towards each exercise.
40
Lee, Yoon Kyung. "Transformation of the Innovative and Sustainable Supply Chain with Upcoming Real-Time Fashion Systems." Sustainability 13, no. 3 (January 21, 2021): 1081. http://dx.doi.org/10.3390/su13031081.
Анотація:
Technologies that are ready-to-use and adaptable in real time to customers’ individual needs are influencing the supply chain of the future. This study proposes a supply chain framework for an innovative and sustainable real-time fashion system (RTFS) between enterprises, designers, and consumers in 3D clothing production systems, using information communication technology, artificial intelligence (AI), and virtual environments. In particular, the RTFS is targeted at customers actively involved in product purchasing, personalising, co-designing, and manufacturing planning. The fashion industry is oriented towards 3D services as a service model, owing to the automation and democratisation of product customisation and personalisation processes. Furthermore, AI offers referral services to prosumers or/and customers and companies, and proposes individual designs with perfect styles and measurements using new 3D computer aided design and AI-based product design technologies for fashion and design companies and customers. Consequently, 3D fashion products in the RTFS supply chain are entirely digital, saving time and money with sampling and tracking capabilities, secured, and trusted with personalised service delivery.
41
Stefanicka-Wojtas, Dorota, Marta Duda-Sikuła, and Donata Kurpas. "Personalised medicine – best practices exchange and personal health implementation in European regions – a qualitative study concept under the Regions4PerMed (h2020) project." Medical Science Pulse 14, no. 1 (June 30, 2020): 1–8. http://dx.doi.org/10.5604/01.3001.0014.2475.
Анотація:
Personalised medicine (PM) is the adaptation of medical treatment to an individual patient. More importantly, PM offers the potential to detect disease earlier when it is easier to treat effectively. PM is beginning to overcome the limitations of traditional medicine. In PM there are many potential benefits and facilitators but also many barriers. The goals of the Regions4PerMed project are to set up the first interregional cooperation on PM, align strategies and financial instruments, and most importantly, identify primary barriers in personal medicine adoption in the health care system and systematic actions to remove as many of them as possible to create a future where PM is fully integrated into real life settings. Each key action activity will be followed by a focus group or semi-structured qualitative interview. The questions asked during the research will concern barriers and facilitators of PM implementation in the country of a subject and will concern: medical big data and electronic medical records; health technology in connected and integrated care; the health industry; facilitate the innovation flow in health care; socio-economic aspects. The qualitative study outcomes are supposed to bring more qualitative data to the discussion. They could be implemented to the daily practice of the health care system’s stakeholders through the best practices transferred to all five key strategic areas of the Regions4PerMed project.
42
Wall, Peter DH, Edward J. Dickenson, David Robinson, Ivor Hughes, Alba Realpe, Rachel Hobson, Damian R. Griffin, and Nadine E. Foster. "Personalised Hip Therapy: development of a non-operative protocol to treat femoroacetabular impingement syndrome in the FASHIoN randomised controlled trial." British Journal of Sports Medicine 50, no. 19 (September 14, 2016): 1217–23. http://dx.doi.org/10.1136/bjsports-2016-096368.
Анотація:
IntroductionFemoroacetabular impingement (FAI) syndrome is increasingly recognised as a cause of hip pain. As part of the design of a randomised controlled trial (RCT) of arthroscopic surgery for FAI syndrome, we developed a protocol for non-operative care and evaluated its feasibility.MethodsIn phase one, we developed a protocol for non-operative care for FAI in the UK National Health Service (NHS), through a process of systematic review and consensus gathering. In phase two, the protocol was tested in an internal pilot RCT for protocol adherence and adverse events.ResultsThe final protocol, called Personalised Hip Therapy (PHT), consists of four core components led by physiotherapists: detailed patient assessment, education and advice, help with pain relief and an exercise-based programme that is individualised, supervised and progressed over time. PHT is delivered over 12–26 weeks in 6–10 physiotherapist-patient contacts, supplemented by a home exercise programme. In the pilot RCT, 42 patients were recruited and 21 randomised to PHT. Review of treatment case report forms, completed by physiotherapists, showed that 13 patients (62%) received treatment that had closely followed the PHT protocol. 13 patients reported some muscle soreness at 6 weeks, but there were no serious adverse events.ConclusionPHT provides a structure for the non-operative care of FAI and offers guidance to clinicians and researchers in an evolving area with limited evidence. PHT was deliverable within the National Health Service, is safe, and now forms the comparator to arthroscopic surgery in the UK FASHIoN trial (ISRCTN64081839).Trial registration numberISRCTN 09754699.
43
Doyle, Shaun. "Personalised web offer management." Journal of Database Marketing & Customer Strategy Management 16, no. 1 (March 2009): 51–56. http://dx.doi.org/10.1057/dbm.2009.3.
44
Barg, Katherin, Simon Benham-Clarke, and Anna Mountford-Zimdars. "Investigating the Imagination of Possible and ‘Like-to-Avoid’ Selves among Higher Education Students from Different Socioeconomic Backgrounds at a Selective English University." Social Sciences 9, no. 5 (May 1, 2020): 67. http://dx.doi.org/10.3390/socsci9050067.
Анотація:
Access to and participation in higher education (HE) remains unequal, with social background continuing to influence decisions and experiences. In this paper, we undertake a proof-of-concept design to apply the theory of ‘possible selves’, as adapted by Harrison and published in Social Sciences (2018), to university students from different socioeconomic backgrounds. In 2019, we conducted semi-structured interviews with 12 first-year students, from different socioeconomic backgrounds, currently studying at a selective English university. We applied a deductive analysis based on Harrison’s adaptation of the ‘possible selves’ model originally put forward by Markus and Nurius in the 1980s. Students from disadvantaged backgrounds had a clear drive to ‘avoid’ future selves that would emerge without HE. Across all socioeconomic groups, we found a strong sense of agency, and a strong personal belief in success. Overall, our study shows that the model of possible selves is useful for understanding personalised and individualised student experiences, and the interrelation between social structure (socioeconomic condition) and agency. The model also offers a new way for practitioners to plan interventions for enhancing equity in HE access and participation.
45
Naaldenberg, Jenneken, and Noelle Aarts. "The compatibility of reductionistic and complexity approaches in a sociomedical innovation perspective." BMJ Global Health 5, no. 12 (December 2020): e003858. http://dx.doi.org/10.1136/bmjgh-2020-003858.
Анотація:
Medical technologies, e-health and personalised medicine are rapidly changing the healthcare landscape. Successful implementation depends on interactions between the technology, the actors and the context. More traditional reductionistic approaches aim to understand isolated factors and linear cause–effect relations and have difficulties in addressing inter-relatedness and interaction. Complexity theory offers a myriad of approaches that focus specifically on behaviour and mechanisms that emerge from interactions between involved actors and the environment. These approaches work from the assumption that change does not take place in isolation and that interaction and inter-relatedness are central concepts to study. However, developments are proceeding fast and along different lines. This can easily lead to confusion about differences and usefulness in clinical and healthcare research and practice. Next to this, reductionistic and complexity approaches have their own merits and much is to be gained from using both approaches complementary. To this end, we propose three lines in complexity research related to health innovation and discuss ways in which complexity approaches and reductionistic approaches can act compatibly and thereby strengthen research designs for developing, implementing and evaluating health innovations.
46
de Bruin, Leon R. "Evolving Regulatory Processes Used by Students and Experts in the Acquiring of Improvisational Skills: A Qualitative Study." Journal of Research in Music Education 65, no. 4 (November 17, 2017): 483–507. http://dx.doi.org/10.1177/0022429417744348.
Анотація:
The way an improviser practices is a vital and significant aspect to a musician’s means and capacities of expression. Expert music performers utilize extensive self-regulatory processes involving planning, strategic development, and systemized approaches to learning and reflective practice. Scholars posit that these processes are constructivist and socioculturally explained and manifest in individual, jointly negotiated, and shared learning. This qualitative study explores the regulatory processes of four prominent Australian improvising musician-educators and four tertiary improvisation students. Expert and developing musicians’ processes in learning and teaching improvised music-making were investigated through observations of self-regulation, co-regulation, and shared regulation strategies. I identified and analyzed regulatory learning strategies located from practice, training, and experience using interpretative phenomenological analysis. Findings suggest insights of evolving self-regulative behavior that are dynamic, task-specific, personalised, and contextually contingent across individual and collaborative tasks and activity. An integrative regulatory model of learning offers guidance and reflection of metacognitive flow within a social constructed view of learning. Implications for researchers and educators are drawn for meaningful educational practice by knowing and understanding expert improvisers’ complex concepts of self-regulation, critical thinking, problem solving, and the evolution and evaluation of creative processes in improvisers.
47
Potera, Carol. "IDBS Now Offers Personalized Medicine Tools." Genetic Engineering & Biotechnology News 31, no. 11 (June 2011): 12–13. http://dx.doi.org/10.1089/gen.31.11.03.
48
Waring, Justin, Simon Bishop, Fiona Marshall, Natasha Tyler, and Robert Vickers. "An ethnographic study comparing approaches to inter-professional knowledge sharing and learning in discharge planning and care transitions." Journal of Health Organization and Management 33, no. 6 (September 5, 2019): 677–94. http://dx.doi.org/10.1108/jhom-10-2018-0302.
Анотація:
Purpose The purpose of this paper is to investigate how three communication interventions commonly used during discharge planning and care transitions enable inter-professional knowledge sharing and learning as a foundation for more integrated working. These interventions include information communication systems, dedicated discharge planning roles and group-based planning activities. Design/methodology/approach A two-year ethnographic study was carried out across two regional health and care systems in the English National Health Service, focussing on the discharge of stroke and hip fracture patients. Data collection involved in-depth observations and 213 semi-structured interviews. Findings Information systems (e.g. e-records) represent a relatively stable conduit for routine and standardised forms of syntactic information exchange that can “bridge” time–space knowledge boundaries. Specialist discharge roles (e.g. discharge coordinators) support personalised and dynamic forms of “semantic” knowledge sharing that can “broker” epistemic and cultural boundaries. Group-based activities (e.g. team meetings) provide a basis for more direct “pragmatic” knowledge translation that can support inter-professional “bonding” at the cultural and organisational level, but where inclusion factors complicate exchange. Research limitations/implications The study offers analysis of how professional boundaries complicate discharge planning and care transition, and the potential for different communication interventions to support knowledge sharing and learning. Originality/value The paper builds upon existing research on inter-professional collaboration and patient safety by focussing on the problems of communication and coordination in the context of discharge planning and care transitions. It suggests that care systems should look to develop multiple complementary approaches to inter-professional communication that offer opportunities for dynamic knowledge sharing and learning.
49
Dreyer, Stephan, Nigel Jamieson, Lisa Evers, Marc Jones, Sancha Martin, Fraser Duthie, Liz Musgrove, et al. "Feasibility and clinical utility of EUS guided biopsy of pancreatic cancer for next-generation genomic sequencing." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): e15755-e15755. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e15755.
Анотація:
e15755 Background: Next-generation sequencing (NGS) has made genomic profiling to guide therapy a reality for many cancer types. The aim of this study is to investigate the feasibility of genomic profiling using standard clinical endoscopic ultrasound (EUS) core biopsy samples of Pancreatic Cancer (PC) to allow personalised cancer care. Methods:Patients undergoing EUS and biopsy for suspicion of PC underwent additional biopsies which was snap frozen. En-face frozen section enabled targeted macro-dissection prior to DNA extraction, quantification and targeted sequencing using a commercially available 151 gene ClearSeq Comprehensive Cancer Panel. Matching formalin-fixed (FFPE) diagnostic EUS biopsy and fresh frozen surgical resection specimens underwent genomic profiling for comparison. Whole genome sequencing (WGS) was performed in 2 patients. RNA sequencing was performed in samples with sufficient RNA yield. Results: Known PC genes ( KRAS, GNAS, TP53, CDKN2A, SMAD4) were identified in 27 out of 30 (90%) patients with histological diagnosis of PC. Potentially actionable somatic mutations (BRCA1, BRCA2, ATM, BRAF, JAK3) were found in 6 (20%) patients. In the 2 samples selected, WGS of the EUS samples confirmed point mutations identified on panel sequencing and revealed relevant mutational signatures and structural variation patterns. Targeted panel sequencing was successful in all FFPE samples. In 1 chemotherapy naïve patient, sequencing of a matching trio of fresh frozen and FFPE EUS biopsies, and resection sample revealed evidence of spatial intra-tumoral heterogeneity. In another patient, pre-treatment biopsy revealed a somatic BRCA1 mutation, and patient had a near complete pathological response to platinum containing neoadjuvant therapy in the resected specimen. RNA sequencing segregated patients into key clinically relevant molecular PC subtypes based on transcriptome as recently described. Conclusions: We demonstrate here novel multi-omic analysis of pancreatic cancer using standard clinical EUS guided fine needle biopsies. Multi-omic analysis of EUS biopsies offers potential clinical utility to guide personalized therapy of PC in the neoadjuvant and advanced settings.
50
Bērziņš, Uldis, Ilze Matise-VanHoutana, Ilze Pētersone, Ilmārs Dūrītis, Sergejs Ņikuļšins, Ance Bogdanova-Jātniece, Mārtiņš Kālis, et al. "Characterisation and In Vivo Safety of Canine Adipose-Derived Stem Cells." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 72, no. 3 (June 1, 2018): 160–71. http://dx.doi.org/10.2478/prolas-2018-0004.
Анотація:
Abstract The study characterises canine adipose-derived stem cells (cASCs) in comparison to human ASCs (hASCs) and tests their safety in a canine model after intravenous administration. cASCs from two dogs were cultured under hypoxic conditions in a medium supplemented with autologous serum. They were plastic adherent, spindle-shaped cells that expressed CD73, CD90, and CD44 but lacked CD45, CD14, HLA-DR, and CD34. cASCs differentiated toward adipogenic, osteogenic, and chondrogenic lineages, although adipogenic differentiation capacity was low. Blast transformation reaction demonstrated that these cells significantly suppress T-cell proliferation, and this ability is dose-dependent. Intravenous administration of a cell freezing medium, therapeutic dose of cASCs (2 × 106 live cells/kg), and five times higher dose of cASCs showed no significant side effects in two dogs. Microscopic tissue lesions were limited to only mild, non-specific changes. There were no signs of malignancy. The results of the study indicate that cASCs are similar to hASCs and are safe for therapeutic applications in a canine model. The proposed methodology for ASC preparation on a non-routine basis, which includes individually optimised cell culture conditions and offers risk-adapted treatment, could be used for future personalised off-the-shelf therapies, for example, in myocardial infarction or stroke.